Senior Post-Doctoral Researcher
Centre For Research In Vascular Biology
CRVB, BSI, UCC, Cork, Ireland

T: +353-21490-1326
E: cl.huang@ucc.ie

Research Interests

Stem Cell Biology/ Cardiovascular Regenerative Medicine



Cellular and Molecular Biology



Peer Reviewed Journals

YearPublication
(2014)'Disabled-2 Is Required for Efficient Haemostasis and Platelet Activation by Thrombin in Mice'
Tsai HJ*, Huang CL*, Chang YW, Huang DY, Lin CC, Cooper JA, Cheng JC, Tseng CP (2014) 'Disabled-2 Is Required for Efficient Haemostasis and Platelet Activation by Thrombin in Mice'. Arteriosclerosis Thrombosis and Vascular Biology, [Details]
(2014)'Intravascular cell-delivery device for therapeutic VEGF-induced angiogenesis in chronic vascular occlusion'
Kumar AH, Martin K, Doyle B, Huang CL, Krishnan G, Ali MT, Skelding KA, Wang S, Gleeson BM, Jahangeer S, Ritman EL, Russell SJ, Caplice NM. (2014) 'Intravascular cell-delivery device for therapeutic VEGF-induced angiogenesis in chronic vascular occlusion'. Biomaterials, [Details]
(2014)'Regenerative Approaches to Post-Myocardial Infarction Heart Failure'
Martin K, Huang CL, Caplice NM (2014) 'Regenerative Approaches to Post-Myocardial Infarction Heart Failure'. Current Pharmaceutical Design, 20 :1930-1940 [Details]
(2013)'Identification of a Klf4-dependent upstream repressor region mediating transcriptional regulation of the myocardin gene in human smooth muscle cells'
Turner EC, Huang CL, Govindarajan K, Caplice NM (2013) 'Identification of a Klf4-dependent upstream repressor region mediating transcriptional regulation of the myocardin gene in human smooth muscle cells'. Biochimica Et Biophysica Acta, 1829 (11):1191-1201 [DOI] [Details]
(2012)'The endocytic adaptor protein Disabled-2 is required for cellular uptake of fibrinogen'
Hung WS*, Huang CL*, Fan JT, Huang DY, Yeh CF, Cheng JC, Tseng CP. (2012) 'The endocytic adaptor protein Disabled-2 is required for cellular uptake of fibrinogen'. Biochimica Et Biophysica Acta, [Details]
(2010)'Disabled-2 is required for mesoderm differentiation of murine embryonic stem cells'
Huang CL, Cheng JC, Kitajima K, Nakano T, Yeh CF, Chong KY, Tseng CP (2010) 'Disabled-2 is required for mesoderm differentiation of murine embryonic stem cells'. Journal Of Cellular Physiology, [Details]
(2010)'Reelin is a platelet protein and functions as a positive regulator of platelet spreading on fibrinogen'
Tseng WL, Huang CL, Chong KY, Liao CH, Stern A, Cheng JC, Tseng CP (2010) 'Reelin is a platelet protein and functions as a positive regulator of platelet spreading on fibrinogen'. Cellular and Molecular Life Sciences, [Details]
(2006)'Disabled-2 is a novel alphaIIb-integrin-binding protein that negatively regulates platelet-fibrinogen interactions and platelet aggregation'
Huang CL, Cheng JC, Stern A, Hsieh JT, Liao CH, Tseng CP (2006) 'Disabled-2 is a novel alphaIIb-integrin-binding protein that negatively regulates platelet-fibrinogen interactions and platelet aggregation'. Journal of Cell Science, [Details]
(2006)'Rapid detection and identification of clinically important bacteria by high-resolution melting analysis after broad-range ribosomal RNA real-time PCR'
Cheng JC, Huang CL, Lin CC, Chen CC, Chang YC, Chang SS, Tseng CP (2006) 'Rapid detection and identification of clinically important bacteria by high-resolution melting analysis after broad-range ribosomal RNA real-time PCR'. Clinical Chemistry And Laboratory Medicine, [Details]
(2005)'The role of DOC-2/DAB2 in modulating androgen receptor-mediated cell growth via the nongenomic c-Src-mediated pathway in normal prostatic epithelium and cancer'
Zhoul J, Hernandez G, Tu SW, Huang CL, Tseng CP, Hsieh JT (2005) 'The role of DOC-2/DAB2 in modulating androgen receptor-mediated cell growth via the nongenomic c-Src-mediated pathway in normal prostatic epithelium and cancer'. Cancer Research, [Details]
(2005)'Autocrine signaling of platelet-derived growth factor regulates disabled-2 expression during megakaryocytic differentiation of K562 cells'
Tseng CP, Chang P, Huang CL, Cheng JC, Chang SS (2005) 'Autocrine signaling of platelet-derived growth factor regulates disabled-2 expression during megakaryocytic differentiation of K562 cells'. Febs Letters, [Details]
(2005)'Rapid detection of glucose-6-phosphate dehydrogenase gene mutations by denaturing high-performance liquid chromatography'
Tseng CP, Huang CL, Chong KY, Hung IJ, Chiu DT (2005) 'Rapid detection of glucose-6-phosphate dehydrogenase gene mutations by denaturing high-performance liquid chromatography'. Clinical biochemistry, [Details]
(2004)'Disabled-2 is a negative regulator of integrin alpha(IIb)beta(3)-mediated fibrinogen adhesion and cell signaling'
Huang CL, Cheng JC, Liao CH, Stern A, Hsieh JT, Wang CH, Hsu HL, Tseng CP (2004) 'Disabled-2 is a negative regulator of integrin alpha(IIb)beta(3)-mediated fibrinogen adhesion and cell signaling'. The Journal of Biological Chemistry, [Details]
(2003)'Disabled-2 small interfering RNA modulates cellular adhesive function and MAPK activity during megakaryocytic differentiation of K562 cells'
Tseng CP, Huang CL, Huang CH, Cheng JC, Stern A, Tseng CH, Chiu DT (2003) 'Disabled-2 small interfering RNA modulates cellular adhesive function and MAPK activity during megakaryocytic differentiation of K562 cells'. Febs Letters, [Details]

Conference Publications

YearPublication
(2013)The International Society on Thrombosis & Haemostatsis XXVI Congress, Amsterdam, Netherlands, 2013
Tsai HJ, Huang CL, Huang DY, Lin CC, Cooper JA, Cheng JC, and Tseng C-P (2013) Disabled-2 is required for efficient platelet activation by thrombin in mouse The International Society on Thrombosis & Haemostatsis XXVI Congress, Amsterdam, Netherlands, 2013 [Details]
(2013)American Heart Association (AHA), BCVS, Las Vegas, USA, 2013
Turner EC, Huang CL, Sawhney N, Govindarajan K, Kumar AHS, Clover JP, Martin K, Leblond AL, Wang S, and Caplice NM (2013) Identification of a novel adult smooth muscle-like stem/progenitor cell that facilitates formation of tissue engineered vascular tissue for use as vascular grafts in vivo American Heart Association (AHA), BCVS, Las Vegas, USA, 2013 [Details]
(2011)The International Society on Thrombosis & Haemostatsis XXIII Congress, Kyoto, Japan, 2011
Huang CL, Tsai HJ, Lin CC, Chang YW, Cooper JA, Cheng JC, and Tseng C-P (2011) In vivo role of Disabled-2 (DAB2) in haemostasis and platelet function: studies using a megakaryocyte lineage-restricted DAB2 knockout The International Society on Thrombosis & Haemostatsis XXIII Congress, Kyoto, Japan, 2011 [Details]
(2010)The 101th Annual Meeting of American Association for Cancer Research (AACR), Washington DC, USA., 2010
Huang CL, Cheng JC, Liu SY, Tseng C-P (2010) Identification of a novel tumor necrosis factor receptor-associated factor 6-binding partner that is a potential lysine-63 linked ubiquitination substrate The 101th Annual Meeting of American Association for Cancer Research (AACR), Washington DC, USA., 2010 [Details]
(2009)The International Society on Thrombosis & Haemostatsis XXII Congress, Boston, USA, 2009
Huang CL, Cheng JC, Lin CC, and Tseng C-P (2009) Disabled-2 is a key regulator during mesodermal differentiation and megakaryopoiesis of murine embryonic stem cells The International Society on Thrombosis & Haemostatsis XXII Congress, Boston, USA, 2009 [Details]
(2009)NHRI Conference, Miaoli County, Taiwan, 2009
Tseng C-P, Huang CL, and Tseng WL (2009) Exploring the role of DAB2 in the blockage of tumor cell-platelet interaction and cancer metastasis NHRI Conference, Miaoli County, Taiwan, 2009 [Details]
(2009)The Chinese Society of Cell and Molecular Biology 17th Annul Meeting, Taiwan, 2009
Tseng WL, Huang CL, Cheng JC, and Tseng C-P (2009) Disabled-2 modulates transferrin trafficking and is a key regulator during sodium butyrate-induced differentiation of K562 cells The Chinese Society of Cell and Molecular Biology 17th Annul Meeting, Taiwan, 2009 [Details]
(2007)The International Society on Thrombosis & Haemostatsis XXIst Congress, Geneva, Switzerland, 2007
Tseng C-P, Chen LL, Huang CL, and Cheng JC (2007) The RGD-containing peptide derived from platelet Disabled-2 inhibits DU145 prostate cancer cell-induced platelet aggregation The International Society on Thrombosis & Haemostatsis XXIst Congress, Geneva, Switzerland, 2007 [Details]
(2007)The International Society on Thrombosis & Haemostatsis XXIst Congress, Geneva, Switzerland, 2007
Huang CL, Cheng JC, and Tseng C-P (2007) Platelet protein Disabled-2 is required for embryonic stem cell-derived mesoderm formation and megakaryocytic differentiation The International Society on Thrombosis & Haemostatsis XXIst Congress, Geneva, Switzerland, 2007 [Details]
(2007)The 15th Annual Meeting of The Chinese Society of Cell and Molecular Biology, Taiwan, 2007
Huang CL, Cheng JC, and Tseng C-P (2007) Disabled-2 is required for development of embryonic stem cell-derived mesoderm The 15th Annual Meeting of The Chinese Society of Cell and Molecular Biology, Taiwan, 2007 [Details]
(2007)The 15th Annual Meeting of The Chinese Society of Cell and Molecular Biology, Taiwan, 2007
Tseng WL, Huang CL, Cheng JC, and Tseng C-P (2007) A shRNA system for lineage- specific gene knockdown during megakaryocytic differentiation The 15th Annual Meeting of The Chinese Society of Cell and Molecular Biology, Taiwan, 2007 [Details]
(2006)The 21th Annual Meeting of Biomedical Society, Taipei, Taiwan, 2006
Huang CL, Cheng JC, Liao CH, and Tseng C-P (2006) Disabled-2 is an anti-adhesive molecule that negatively regulates platelet-fibrinogen interactions and platelet aggregation The 21th Annual Meeting of Biomedical Society, Taipei, Taiwan, 2006 [Details]
(2006)The 14th Annual Meeting of The Chinese Society of Cell and Molecular Biology, Taiwan, 2006
Huang CL, and Tseng C-P (2006) Disabled-2 is a negative regulator of integrin aIIbb3- mediated fibrinogen adhesion and platelet aggregation The 14th Annual Meeting of The Chinese Society of Cell and Molecular Biology, Taiwan, 2006 [Details]
(2005)The 3rd NHRI Conference on Signal Transduction, Taipei, Taiwan, 2005
Tseng C-P, Huang CL, Cheng JC, Liao CH (2005) Disabled-2 is a negative regulator of integrin aIIbb3-mediated fibrinogen adhesion and cell signaling The 3rd NHRI Conference on Signal Transduction, Taipei, Taiwan, 2005 [Details]
(2005)The International Society on Thrombosis & Haemostatsis XXth Congress, Sydney, Australia, 2005
Tseng C-P, Huang CL, Cheng JC, Liao CH (2005) Disabled-2 is a secreted anti-adhesive molecule during platelet activation and aggregation The International Society on Thrombosis & Haemostatsis XXth Congress, Sydney, Australia, 2005 [Details]
(2005)The 20th Annual Meeting of Biomedical Society, Taipei, Taiwan, 2005
Huang CL, Cheng JC, and Tseng C-P (2005) The role of Disabled-2 in integrin aIIbb3-mediated fibrinogen adhesion and cell signaling during megakaryocytic differentiation The 20th Annual Meeting of Biomedical Society, Taipei, Taiwan, 2005 [Details]
(2004)The 95th Annual Meeting of American Association for Cancer Research (AACR), Orlando FL, USA, 2004
Tseng C-P, Huang CL, Cheng JC (2004) Serine 24 phosphorylation of Disabled-2 negatively regulates K562 cell adhesion to fibrinogen The 95th Annual Meeting of American Association for Cancer Research (AACR), Orlando FL, USA, 2004 [Details]
(2003)The 18th Annual Meeting of Biomedical Society, Taipei, Taiwan, 2003
Huang CL, Huang CH, Cheng JC, Wei JS, and Tseng C-P (2003) Modulation of Disabled-2 gene expression by DNA vector-based RNA interference (RNAi) The 18th Annual Meeting of Biomedical Society, Taipei, Taiwan, 2003 [Details]
(2003)2nd NHRI Conference on Signal Transduction, Taipei, Taiwan, 2003
Tseng C-P, Huang CL, Huang CH, Lee CH, and Cheng JC (2003) The regulation and functions of the adaptor protein Disabled-2 in megakaryocytic differentiation of K562 cells 2nd NHRI Conference on Signal Transduction, Taipei, Taiwan, 2003 [Details]
(2003)FEBS 2003 meeting on signal transduction, Brussels, Belgium, 2003
Tseng C-P, Cheng JC, Huang CL, Huang CH, Lee CH (2003) Involvement of Disabled-2 in the regulation of cellular adhesive function and MAPK activity during megakaryocytic differentiation of K562 cells FEBS 2003 meeting on signal transduction, Brussels, Belgium, 2003 [Details]

Honours and Awards

 YearTitleAwarding Body
2014Government of Ireland Postdoctoral Fellowship Grant Irish Research Council (GOIPD/2014/10, amount: €91,790)
2014ATVB Travel Award for Young Investigators American Heart Association Scientific Sessions 2014
2011Young Investigator Awards (ISTH2011) 23rd Congress of the International Society on Thrombosis and Haemostasis (ISTH2011)
2008First Prize Thesis Award Graduate Institute of Biomedical Sciences, Chang Gung University, Taiwan
2006Professor Chang, M. J. W. memorial scholarship Chang Gung University, Taiwan
2006Outstanding Poster Thesis Awards 21st Joint Annual Conference of Biomedical Science, Taipei, Taiwan
2005Professor Chang, M. J. W. memorial scholarship Chang Gung University, Taiwan
2004First Prize Thesis Award Graduate Institute of Medical Biotechnology, Chang Gung University, Taiwan
2002National Undergraduate Students Innovative Research Awards National Science Council, Taiwan
2001Outstanding Academic Performance Awards and Scholarship Chang Gung University, Taiwan
2009Travel Grants/Awards Foundation for the advancement of outstanding scholarship/ The Chinese Society of Cell and Molecular Biology
2005Travel Grants/Awards Chang Gung University
2006Outstanding Thesis Awards 14th Annual Meeting of the Chinese Society of Cell and Molecular Biology, Taiwan
2005Youth Achievement Award Chang Gung University, Taiwan
2010NSC Travel Grants (NSC-99-2914-I-182-003-A1) National Science Council (NSC-99-2914-I-182-003-A1)
2007NSC Travel Grants (NSC-96-2922-I-182-005) National Science Council (NSC-96-2922-I-182-005)
2007Travel Grants/Awards The Chinese Society of Cell and Molecular Biology/ Chang Gung University
2002NSC Undergraduate Student Research Grant and Assistantship National Science Council (NSC-90-2815-C-182-009-B)

Professional Associations

 AssociationFunctionFrom / To
American Heart Association Early Career Member in the Council on Arteriosclerosis, Thrombosis, and Vascular Biology28-MAY-14 /
IMB Individual Authorization on Animal Procedures Rodents Procedures07-MAR-14 / 06-MAR-19
License of Medical Examiners From The Examination Yuan of ROC01-SEP-02 /

Employment

 EmployerPositionFrom / To
CRVB, UCC, Ireland Senior Post-Doctoral Researcher13-JAN-14 /
CRVB, UCC, Ireland Post Doctoral Researcher15-APR-11 / 12-JAN-14
CGU, Taiwan Post Doctoral Fellow01-APR-09 / 31-MAR-11

Education

 YearInstituionQualificationSubject
2009Graduate Institute of Biomedical Sciences, CGU, Taiwan PhDStem Cell Biology/ Hematology/ Cellular and Molecular Biology
2004Graduate Institute of Medical Biotechnology, CGU, Taiwan MScCellular and Molecular Biology

Languages

 LanguageReadingWritingSpeaking
English FluentFluentFluent
Chinese FluentFluentFluent

Journal Activities

 JournalRoleTo / From
Nature Biotechnology Referee-
J. Clin. Invest Referee-

Teaching Interests

Stem Cell Biology/ Hematology
Cellular and Molecular Biology