Research Profile

Michael Clarkson

Biography

Areas of Interest:  Vasculitis and kidney transplantation.

Dr Clarkson (MB, BAO BCh, University of Dublin, Trinity College 1994) undertook postgraduate training in Internal Medicine and Nephrology in Dublin 1994-2001 and was awarded an MD by thesis in 2002. He completed a clinical and research fellowship at The Brigham and Women’s Hospital and the Massachusetts General Hospital, Harvard Medical School, Boston (2001-2004). He was appointed to the staff of the Brigham and Women’s Hospital before taking up his current position in CUH in 2005.

His research interests include the immunobiology of transplant rejection and small vessel vasculitis. Dr Clarkson is the recipient of a Programme Project Grant from the Health Research Board of Ireland, has authored or co-authored over 35 peer-reviewed scientific papers, 8 book chapters and is editor of the Companion Handbook to Brenner and Rector’s ‘The Kidney'.

Dr Clarkson provides an outreach service to Kerry General Hospital.

Research Interests

My research interests include the immunobiology of transplant rejection and small vessel vasculitis. I have authored or co-authored over 35 peer-reviewed scientific papers, 8 book chapters and is editor of the Companion Handbook to Brenner and Rector’s ‘The Kidney'.

Below are my current research projects:

2018  - present: Principal Investigator. IFX-1-P2.5 Study. A randomized, double-blind, double-dummy, placebo-controlled, multicenter, Phase IIa study on replacement of steroids by IFX-1 during induction and remission therapy in ANCA-associated vasculitis. Commencing Q1 2019.

2017-  present. Principal Investigator. Advocate Study. A randomized, double blind, placebo-controlled Phase 3 Study to evaluate the safety and efficacy of CCX168 (Avacopan) in Patients with ANCA-associated vasculitis treated concurrently with Rituximab or Cyclophosphamide/Azathioprine.  

2015- present: National Coordinator and Principal Investigator. Dolomites Study. A Phase 3, randomized, open-label, active-controlled study to evaluate the efficacy and safety of FG-4592 in the treatment of anemia in chronic kidney disease patients not on dialysis.

2016-2017: Principal Investigator. Ritazarem Study. An international, investigator-led, open-label, randomized controlled trial comparing rituximab with azathioprine as maintenance therapy in relapsing ANCA-associated vasculitis.

2013 - present: Principal Investigator. Rare Kidney Disease Registry and Biosource.  

Research Grants

 ProjectFunding
Body
Start DateEnd DateAward
Mechanisms of Tolerance in Human Kidney Transplant RecipientsOther: Not Listed
OX40-OX40L Interactions in Ischemia-Reperfusion InjuryOther: Not Listed
TIM-1 in T cell Activation and ToleranceHealth Research Board
Expression of the Lipoxin A4 Receptor in Experimental and Human GlomerulonephritisHealth Research Board
The Role of the Novel Transcription Factor T-Bet in Humoral AllograftOther: Not Listed

Publications

Peer Reviewed Journals

 YearPublication
(2018)'Erratum: Urinary soluble CD163 in active renal vasculitis (Journal of the American Society of Nephrology (2016) 27 (2906-2916) DOI: 10.1681/ASN.2015050511)'
O’Reilly, V. P.,Wong, L.,Kennedy, C.,Elliot, L. A.,O’Meachair, S.,Coughlan, A. M.,O’Brien, E. C.,Ryan, M. M.,Sandoval, D.,Connolly, E.,Dekkema, G. J.,Lau, J.,Abdulahad, W. H.,Sanders, J. S. F.,Heeringa, P.,Buckley, C.,O’Brien, C.,Finn, S.,Cohen, C. D.,Lindemeyer, M. T.,Hickey, F. B.,O’Hara, P. V.,Feighery, C.,Moran, S. M.,Mellotte, G.,Clarkson, M. R.,Dorman, A. J.,Murray, P. T.,Little, M. A. (2018) 'Erratum: Urinary soluble CD163 in active renal vasculitis (Journal of the American Society of Nephrology (2016) 27 (2906-2916) DOI: 10.1681/ASN.2015050511)'. Journal of the American Society of Nephrology, 29 (8)   [DOI] [Details]
(2017)'Neurological consults on the renal unit'
Kelly, D. M.,Clarkson, M. R.,Cronin, S. (2017) 'Neurological consults on the renal unit'. Practical Neurology, 17 (2):104-112   [DOI] [Details]
(2016)'Spatial and temporal clustering of anti-glomerular basement membrane disease'
Canney, M.,O’Hara, P. V.,McEvoy, C. M.,Medani, S.,Connaughton, D. M.,Abdalla, A. A.,Doyle, R.,Stack, A. G.,O’Seaghdha, C. M.,Clarkson, M. R.,Griffin, M. D.,Holian, J.,Dorman, A. M.,Niland, A.,Keogan, M.,Wallace, E. M.,Conlon, N. P.,Walsh, C.,Kelly, A.,Little, M. A. (2016) 'Spatial and temporal clustering of anti-glomerular basement membrane disease'. Clinical Journal of the American Society of Nephrology, 11 (8):1392-1399   [DOI] [Details]
(2016)'Urinary soluble CD163 in active renal vasculitis'
O'Reilly, V. P.,Wong, L.,Kennedy, C.,Elliot, L. A.,O'Meachair, S.,Coughlan, A. M.,O'Brien, E. C.,Ryan, M. M.,Sandoval, D.,Connolly, E.,Dekkema, G. J.,Lau, J.,Abdulahad, W. H.,Sanders, J. S. F.,Heeringa, P.,Buckley, C.,O'Brien, C.,Finn, S.,Cohen, C. D.,Lindemeyer, M. T.,Hickey, F. B.,O'Hara, P. V.,Feighery, C.,Moran, S. M.,Mellotte, G.,Clarkson, M. R.,Dorman, A. J.,Murray, P. T.,Little, M. A. (2016) 'Urinary soluble CD163 in active renal vasculitis'. Journal of the American Society of Nephrology, 27 (9):2906-2916   [DOI] [Details]
(2015)'Posterior reversible encephalopathy syndrome in end-stage kidney disease: Not strictly posterior or reversible'
Canney, M.,Kelly, D.,Clarkson, M. (2015) 'Posterior reversible encephalopathy syndrome in end-stage kidney disease: Not strictly posterior or reversible'. American Journal of Nephrology, 41 (3):177-182   [DOI] [Details]
(2013)'CD160Ig Fusion Protein Targets a Novel Costimulatory Pathway and Prolongs Allograft Survival'
D'Addio, F.,Ueno, T.,Clarkson, M.,Zhu, B.,Vergani, A.,Freeman, G. J.,Sayegh, M. H.,Ansari, M. J. I.,Fiorina, P.,Habicht, A. (2013) 'CD160Ig Fusion Protein Targets a Novel Costimulatory Pathway and Prolongs Allograft Survival'. PLoS ONE, 8 (4)   [DOI] [Details]
(2012)'Serum D-dimer concentrations in nephrotic syndrome track with albuminuria, not estimated glomerular filtration rate'
Sexton, D. J.,Clarkson, M. R.,Mazur, M. J.,Plant, W. D.,Eustace, J. A. (2012) 'Serum D-dimer concentrations in nephrotic syndrome track with albuminuria, not estimated glomerular filtration rate'. American Journal of Nephrology, 36 (6):554-560   [DOI] [Details]
(2012)'Quiz page December 2012: bilateral kidney enlargement and acute kidney injury in a patient with HIV infection'
Sexton, D. J.,Plant, W. D.,Eustace, J. A.,Clarkson, M. R. (2012) 'Quiz page December 2012: bilateral kidney enlargement and acute kidney injury in a patient with HIV infection'. American journal of kidney diseases : the official journal of the National Kidney Foundation, 60 (6)   [Details]
(2011)'The incidence and clinical correlates of lithium toxicity: A retrospective review'
Dennison, U.,Clarkson, M.,O'Mullane, J.,Cassidy, E. M. (2011) 'The incidence and clinical correlates of lithium toxicity: A retrospective review'. Irish Journal of Medical Science, 180 (3):661-665   [DOI] [Details]
(2011)'Haemodialysis-induced syncope due to Chiari II malformation'
Sexton, D. J.,Vaughan, K. M.,Moran, C.,Plant, W. D.,Clarkson, M. R.,Eustace, J. A. (2011) 'Haemodialysis-induced syncope due to Chiari II malformation'. NDT Plus, 4 (6):390-391   [DOI] [Details]
(2011)'Perplexing plain abdominal x-ray'
Crush, L.,O'Connor, O. J.,Plant, W.,Clarkson, M. R.,Shanahan, F.,Maher, M. M. (2011) 'Perplexing plain abdominal x-ray'. Gut, 60 (2)   [DOI] [Details]
(2011)'Tim-4 inhibition of T-cell activation and T helper type 17 differentiation requires both the immunoglobulin V and mucin domains and occurs via the mitogen-activated protein kinase pathway'
Cao, W.,Ryan, M.,Buckley, D.,O'Connor, R.,Clarkson, M. R. (2011) 'Tim-4 inhibition of T-cell activation and T helper type 17 differentiation requires both the immunoglobulin V and mucin domains and occurs via the mitogen-activated protein kinase pathway'. Immunology, 133 (2):179-189   [DOI] [Details]
(2010)'Severe rhabdomyolysis as a consequence of the interaction of fusidic acid and atorvastatin'
Magee, C. N.,Medani, S. A.,Leavey, S. F.,Conlon, P. J.,Clarkson, M. R. (2010) 'Severe rhabdomyolysis as a consequence of the interaction of fusidic acid and atorvastatin'. American Journal of Kidney Diseases, 56 (5)   [DOI] [Details]
(2010)'A case report of spontaneous mutation (C33 > U) in the iron-responsive element of l-ferritin causing hyperferritinemia-cataract syndrome'
Cao, W.,McMahon, M.,Wang, B.,O'Connor, R.,Clarkson, M. (2010) 'A case report of spontaneous mutation (C33 > U) in the iron-responsive element of l-ferritin causing hyperferritinemia-cataract syndrome'. Blood Cells, Molecules, and Diseases, 44 (1):22-27   [DOI] [Details]
(2010)'Maintenance hemodialysis patients have high cumulative radiation exposure'
Kinsella, S. M.,Coyle, J. P.,Long, E. B.,McWilliams, S. R.,Maher, M. M.,Clarkson, M. R.,Eustace, J. A. (2010) 'Maintenance hemodialysis patients have high cumulative radiation exposure'. Kidney Int, 78 (88):789-93789 [Details]
(2009)'Targeting Tim-1 to overcome resistance to transplantation tolerance mediated by CD8 T17 cells'
Yuan, X.,Ansari, M. J.,D'Addio, F.,Paez-Cortez, J.,Schmitt, I.,Donnarumma, M.,Boenisch, O.,Zhao, X.,Popoola, J.,Clarkson, M. R.,Yagita, H.,Akiba, H.,Freeman, G. J.,Iacomini, J.,Turka, L. A.,Glimcher, L. H.,Sayegh, M. H. (2009) 'Targeting Tim-1 to overcome resistance to transplantation tolerance mediated by CD8 T17 cells'. Proceedings of the National Academy of Sciences of the United States of America, 106 (26):10734-10739   [DOI] [Details]
(2008)'A novel role of CD4 Th17 cells in mediating cardiac allograft rejection and vasculopathy'
Yuan, X.,Paez-Cortez, J.,Schmitt-Knosalla, I.,D'Addio, F.,Mfarrej, B.,Donnarumma, M.,Habicht, A.,Clarkson, M. R.,Iacomini, J.,Glimcher, L. H.,Sayegh, M. H.,Javeed Ansari, M. (2008) 'A novel role of CD4 Th17 cells in mediating cardiac allograft rejection and vasculopathy'. Journal of Experimental Medicine, 205 (13):3133-3144   [DOI] [Details]
(2008)'The emerging role of T cell Ig mucin 1 in alloimmune responses in an experimental mouse transplant model'
Ueno, T.,Habicht, A.,Clarkson, M. R.,Albin, M. J.,Yamaura, K.,Boenisch, O.,Popoola, J.,Wang, Y.,Yagita, H.,Akiba, H.,Ansari, M. J.,Yang, J.,Turka, L. A.,Rothstein, D. M.,Padera, R. F.,Najafian, N.,Sayegh, M. H. (2008) 'The emerging role of T cell Ig mucin 1 in alloimmune responses in an experimental mouse transplant model'. Journal of Clinical Investigation, 118 (2):742-751   [DOI] [Details]
(2007)'A novel alloantigen-specific CD8+PD1+ regulatory T cell induced by ICOS-B7h blockade in vivo'
Izawa, A.,Yamaura, K.,Albin, M. J.,Jurewicz, M.,Tanaka, K.,Clarkson, M. R.,Ueno, T.,Habicht, A.,Freeman, G. J.,Yagita, H.,Abdi, R.,Pearson, T.,Greiner, D. L.,Sayegh, M. H.,Najafian, N. (2007) 'A novel alloantigen-specific CD8+PD1+ regulatory T cell induced by ICOS-B7h blockade in vivo'. Journal of Immunology, 179 (2):786-796   [DOI] [Details]
(2007)'New insights in CD28-independent allograft rejection'
Habicht, A.,Najafian, N.,Yagita, H.,Sayegh, M. H.,Clarkson, M. R. (2007) 'New insights in CD28-independent allograft rejection'. American Journal of Transplantation, 7 (8):1917-1926   [DOI] [Details]
(2006)'Critical, but conditional, role of OX40 in memory T cell-mediated rejection'
Vu, M. D.,Clarkson, M. R.,Yagita, H.,Turka, L. A.,Sayegh, M. H.,Li, X. C. (2006) 'Critical, but conditional, role of OX40 in memory T cell-mediated rejection'. Journal of Immunology, 176 (3):1394-1401   [DOI] [Details]
(2006)'Regulation of IL-1 and TNF receptor expression and function by endogenous macrophage migration inhibitory factor'
Toh, M. L.,Aeberli, D.,Lacey, D.,Yang, Y.,Santos, L. L.,Clarkson, M.,Sharma, L.,Clyne, C.,Morand, E. F. (2006) 'Regulation of IL-1 and TNF receptor expression and function by endogenous macrophage migration inhibitory factor'. Journal of Immunology, 177 (7):4818-4825   [DOI] [Details]
(2006)'Novel insights into the mechanism of action of FTY720 in a transgenic model of allograft rejection: Implications for therapy of chronic rejection'
Habicht, A.,Clarkson, M. R.,Yang, J.,Henderson, J.,Brinkmann, V.,Fernandes, S.,Jurewicz, M.,Yuan, X.,Sayegh, M. H. (2006) 'Novel insights into the mechanism of action of FTY720 in a transgenic model of allograft rejection: Implications for therapy of chronic rejection'. Journal of Immunology, 176 (1):36-42   [DOI] [Details]
(2006)'A novel mechanism of action for anti-thymocyte globulin: Induction of CD4+CD25+Foxp3+ regulatory T cells'
Lopez, M.,Clarkson, M. R.,Albin, M.,Sayegh, M. H.,Najafian, N. (2006) 'A novel mechanism of action for anti-thymocyte globulin: Induction of CD4+CD25+Foxp3+ regulatory T cells'. Journal of the American Society of Nephrology, 17 (10):2844-2853   [DOI] [Details]
(2005)'Mechanisms of tolerance induced by donor-specific transfusion and ICOS-B7h blockade in a model of CD4+ T-cell-mediated allograft rejection'
Sandner, S. E.,Clarkson, M. R.,Salama, A. D.,Sanchez-Fueyo, A.,Yagita, H.,Turka, L. A.,Sayegh, M. H. (2005) 'Mechanisms of tolerance induced by donor-specific transfusion and ICOS-B7h blockade in a model of CD4+ T-cell-mediated allograft rejection'. American Journal of Transplantation, 5 (1):31-39   [DOI] [Details]
(2005)'Role of the programmed death-1 pathway in regulation of alloimmune responses in vivo'
Sandner, S. E.,Clarkson, M. R.,Salama, A. D.,Sanchez-Fueyo, A.,Domenig, C.,Habicht, A.,Najafian, N.,Yagita, H.,Azuma, M.,Turka, L. A.,Sayegh, M. H. (2005) 'Role of the programmed death-1 pathway in regulation of alloimmune responses in vivo'. Journal of Immunology, 174 (6):3408-3415   [DOI] [Details]
(2005)'Analysis of the role of negative T cell costimulatory pathways in CD4 and CD8 T cell-mediated alloimmune responses in vivo'
Ito, T.,Ueno, T.,Clarkson, M. R.,Yuan, X.,Jurewicz, M. M.,Yagita, H.,Azuma, M.,Sharpe, A. H.,Auchincloss Jr, H.,Sayegh, M. H.,Najafian, N. (2005) 'Analysis of the role of negative T cell costimulatory pathways in CD4 and CD8 T cell-mediated alloimmune responses in vivo'. Journal of Immunology, 174 (11):6648-6656   [DOI] [Details]
(2005)'T-cell costimulatory pathways in allograft rejection and tolerance'
Clarkson, M. R.,Sayegh, M. H. (2005) 'T-cell costimulatory pathways in allograft rejection and tolerance'. Transplantation, 80 (5):555-563   [DOI] [Details]
(2005)'CD70 signaling is critical for CD28-independent CD8+ T cell-mediated alloimmune responses in vivo'
Yamada, A.,Salama, A. D.,Sho, M.,Najafian, N.,Ito, T.,Forman, J. P.,Kewalramani, R.,Sandner, S.,Harada, H.,Clarkson, M. R.,Mandelbrot, D. A.,Sharpe, A. H.,Oshima, H.,Yagita, H.,Chalasani, G.,Lakkis, F. G.,Auchincloss Jr, H.,Sayegh, M. H. (2005) 'CD70 signaling is critical for CD28-independent CD8+ T cell-mediated alloimmune responses in vivo'. Journal of Immunology, 174 (3):1357-1364   [DOI] [Details]
(2004)'Impaired renal allograft, but not patient survival, in patients with antibodies to hepatitis C virus'
Giblin, L.,Clarkson, M. R.,Conlon, P. J.,Walshe, J. J.,O'Kelly, P.,Hickey, D.,Little, D.,Keoghan, M.,Donohoe, J. (2004) 'Impaired renal allograft, but not patient survival, in patients with antibodies to hepatitis C virus'. Irish Journal of Medical Science, 173 (2):82-84   [DOI] [Details]
(2004)'Analysis of regulatory T cell function from kidney transplant patients on MMF based immunosuppressive protocol'
Tsaur, I.,Gasser, M.,Lopau, K.,Bueter, M.,Trumpfheller, A.,Dragan, M.,Opitz, A.,Kist-Van-Holthe, J. E.,Clarkson, M.,Mueller, S.,Thiede, A.,Meyer, D.,Waaga-Gasser, A. M. (2004) 'Analysis of regulatory T cell function from kidney transplant patients on MMF based immunosuppressive protocol'. Transplantationsmedizin: Organ der Deutschen Transplantationsgesellschaft, 16 (2):106-108   [Details]
(2004)'Acute interstitial nephritis: Clinical features and response to corticosteroid therapy'
Clarkson, M. R.,Giblin, L.,O'Connell, F. P.,O'Kelly, P.,Walshe, J. J.,Conlon, P.,O'Meara, Y.,Dormon, A.,Campbell, E.,Donohoe, J. (2004) 'Acute interstitial nephritis: Clinical features and response to corticosteroid therapy'. Nephrology Dialysis Transplantation, 19 (11):2778-2783   [DOI] [Details]
(2003)'Regulatory functions of CD8+CD28- T cells in an autoimmune disease model'
Najafian, N.,Chitnis, T.,Salama, A. D.,Zhu, B.,Benou, C.,Yuan, X.,Clarkson, M. R.,Sayegh, M. H.,Khoury, S. J. (2003) 'Regulatory functions of CD8+CD28- T cells in an autoimmune disease model'. The Journal of clinical investigation, 112 (7):1037-1048   [Details]
(2003)'Regulatory CD25+ T cells in human kidney transplant recipients'
Salama, A. D.,Najafian, N.,Clarkson, M. R.,Harmon, W. E.,Sayegh, M. H. (2003) 'Regulatory CD25+ T cells in human kidney transplant recipients'. Journal of the American Society of Nephrology, 14 (6):1643-1651   [DOI] [Details]
(2003)'Enteric-Coated Mycophenolate Sodium'
Gabardi, S.,Tran, J. L.,Clarkson, M. R. (2003) 'Enteric-Coated Mycophenolate Sodium'. Annals of Pharmacotherapy, 37 (11):1685-1693   [DOI] [Details]
(2002)'High glucose-altered gene expression in mesangial cells. Actin-regulatory protein gene expression is triggered by oxidative stress and cytoskeletal disassembly'
Clarkson, M. R.,Murphy, M.,Gupta, S.,Lambe, T.,Mackenzie, H. S.,Godson, C.,Martin, F.,Brady, H. R. (2002) 'High glucose-altered gene expression in mesangial cells. Actin-regulatory protein gene expression is triggered by oxidative stress and cytoskeletal disassembly'. Journal of Biological Chemistry, 277 (12):9707-9712   [DOI] [Details]
(2002)'Erratum: High glucose-altered gene expression in mesangial cells. Actin-regulatory protein gene expression is triggered by oxidative stress and cytoskeletal disassembly (The Journal of Biological Chemistry (2002) 277 (9707-9712))'
Clarkson, M. R.,Murphy, M.,Gupta, S.,Lambe, T.,Mackenzie, H. S.,Godson, C.,Martin, F.,Brady, H. R. (2002) 'Erratum: High glucose-altered gene expression in mesangial cells. Actin-regulatory protein gene expression is triggered by oxidative stress and cytoskeletal disassembly (The Journal of Biological Chemistry (2002) 277 (9707-9712))'. Journal of Biological Chemistry, 277 (25):23100-23102   [Details]
(2002)'Reversal of pulmonary hypertension after ligation of a brachiocephalic arteriovenous fistula'
Clarkson, M. R.,Giblin, L.,Brown, A.,Little, D.,Donohoe, J. (2002) 'Reversal of pulmonary hypertension after ligation of a brachiocephalic arteriovenous fistula'. American journal of kidney diseases : the official journal of the National Kidney Foundation, 40 (3)   [Details]
(2000)'Connective tissue growth factor: Potential role in glomerulosclerosis and tubulointerstitial fibrosis'
Gupta, S.,Clarkson, M. R.,Duggan, J.,Brady, H. R. (2000) 'Connective tissue growth factor: Potential role in glomerulosclerosis and tubulointerstitial fibrosis'. Kidney International, 58 (4):1389-1399   [DOI] [Details]
(2000)'IHG-2, a mesangial cell gene induced by high glucose, is human gremlin: Regulation by extracellular glucose concentration, cyclic mechanical strain, and transforming growth factor-ß1'
McMahon, R.,Murphy, M.,Clarkson, M.,Taal, M.,Mackenzie, H. S.,Godson, C.,Martin, F.,Brady, H. R. (2000) 'IHG-2, a mesangial cell gene induced by high glucose, is human gremlin: Regulation by extracellular glucose concentration, cyclic mechanical strain, and transforming growth factor-ß1'. Journal of Biological Chemistry, 275 (14):9901-9904   [DOI] [Details]
(1999)'Connective tissue growth factor: A potential stimulus for glomerulosclerosis and tubulointerstitial fibrosis in progressive renal disease'
Clarkson, M. R.,Gupta, S.,Murphy, M.,Martin, F.,Godson, C.,Brady, H. R. (1999) 'Connective tissue growth factor: A potential stimulus for glomerulosclerosis and tubulointerstitial fibrosis in progressive renal disease'. Current Opinion in Nephrology and Hypertension, 8 (5):543-548   [DOI] [Details]
(1998)'Collapsing glomerulopathy - Recurrence in a renal allograft'
Clarkson, M. R.,O'Meara, Y. M.,Murphy, B.,Rennke, H. G.,Brady, H. R. (1998) 'Collapsing glomerulopathy - Recurrence in a renal allograft'. Nephrology Dialysis Transplantation, 13 (2):503-506   [DOI] [Details]
(1998)'Leukotrienes and lipoxins: Lipoxygenase-derived modulators of leukocyte recruitment and vascular tone in glomerulonephritis'
Clarkson, M. R.,McGinty, A.,Godson, C.,Brady, H. R. (1998) 'Leukotrienes and lipoxins: Lipoxygenase-derived modulators of leukocyte recruitment and vascular tone in glomerulonephritis'. Nephrology Dialysis Transplantation, 13 (12):3043-3051   [DOI] [Details]

Books

 YearPublication
(2010)Pocket Companion to Brenner and Rector’s The Kidney, 8th edition.
Clarkson M.R., Magee C.N., Brenner B.M. (2010) Pocket Companion to Brenner and Rector’s The Kidney, 8th edition. Philadelphia: W.B. Saunders. [Details]
(2005)Pocket Companion to Brenner and Rector’s The Kidney, 7th edition.
Clarkson M.R., Brenner B.M. (2005) Pocket Companion to Brenner and Rector’s The Kidney, 7th edition. Philadelphia: W.B. Saunders. [Details]

Book Chapters

 YearPublication
(2012)'Kidney transplant immunology'
Kennedy, C.,Clarkson, M. (2012) 'Kidney transplant immunology' In: Nephropathy: Diagnosis and Treatment.   [Details]
(2007)'Acute Kidney Injury'
Clarkson M.R, Friedwald J.J, Eustace J.A., Rabb H. (2007) 'Acute Kidney Injury' In: Brenner B.M (eds). Brenner and Rector’s The Kidney, 8th edition. Philadelphia: W.B. Saunders. [Details]
(2003)'Acute Renal Failure'
Brady H.R., Clarkson M.R., Liberthal W. (2003) 'Acute Renal Failure' In: In Brenner B.M (eds). Brenner and Rector’s The Kidney, 7th edition. Philadelphia: W.B. Saunders. [Details]
(2001)'Leukocyte Adhesion'
Clarkson M.R., Brady H.R.. (2001) 'Leukocyte Adhesion' In: Neilson E.G., Couser W.G (eds). Immunologic Renal Diseases, 2nd edition. Philadelphia: Lippencott, Williams & Wilkins. [Details]
(2001)'Acute Renal Failure'
Clarkson M.R., Brady H.R. (2001) 'Acute Renal Failure' In: Van Der Woude (eds). Nephrology, 1st edition. London: McGraw-Hill. [Details]
(1999)'Evaluation of the Patient with Proteinuria, with or without the Nephrotic Syndrome'
O’Meara Y.M., Clarkson M.R., Bernard D.B. (1999) 'Evaluation of the Patient with Proteinuria, with or without the Nephrotic Syndrome' In: Bone (eds). Current Practice of Medicine 2nd edition. New York: Churchill Livingstone. [Details]
(1999)'Acute Renal Failure'
Brady H.R., Brenner B.M., Clarkson M.R., Lieberthal W. (1999) 'Acute Renal Failure' In: Brenner B.M (eds). Brenner B.M. (ed.) Brenner and Rector’s The Kidney, 6th edition. Philadelphia: W.B. Saunders. [Details]
(1999)'Dopamine, Atrial Natriuretic Peptide and Growth Factors in Acute Renal Failure'
Denton M.D., Ooi H., Coleman P.L., Clarkson M.R., Brady H.R. (1999) 'Dopamine, Atrial Natriuretic Peptide and Growth Factors in Acute Renal Failure' In: Owen WF (eds). Dialysis and transplantation: A companion to Brenner and Rector’s The Kidney. Philadelphia: W.B. Saunders. [Details]

Conference Publications

 YearPublication
(2008)Clinical Journal of the American Society of Nephrology
Magee, C.,Clarkson, M.,Rennke, H. (2008) A case of desensitization, transplantation, and allograft dysfunction Clinical Journal of the American Society of Nephrology , pp.1573-1581   [DOI] [Details]
(1999)Nephrology Dialysis Transplantation
McGinty, A.,Clarkson, M.,Brady, H. R. (1999) The value of gene 'knock-out' for assessing the role of cell adhesion molecules in renal disease Nephrology Dialysis Transplantation , pp.27-29   [Details]

Professional Activities

Honours and Awards

 YearTitleAwarding Body
1994Meath Hospital Senior Clinical Medal. Awarded by the Professors of Surgery and Medicine at the Meath Hospital Dublin.
1994GB Hutchison Bequest - Overall first place in Final Examinations Trinity College Dublin.
1994Reuben Harvey Prize - Overall first place in Final Examinations Royal College of Physicians of Ireland.
1994Fitzpatrick Scholarship - Overall first place in Final Examinations Trinity College Dublin.
1994Sir James Craig Memorial Prize - Overall first place in Medicine in Final Examinations Trinity College Dublin.
1994Professors Prize in Psychiatry Awarded by the Professor of Psychiatry, Trinity College Dublin.
1993National Children’s Hospital Board of Governors Prize in Paediatrics Board of Governors of The National Children’s Hospital of Ireland.
1993First place in Social and Preventative Medicine De Renzy Centenary Prize.

Professional Associations

 AssociationFunctionFrom / To
Cork University Hospital Director of Postgraduate Medical Education01-SEP-06 / 31-AUG-09
Irish National Guidelines for the Management of ANCA-associated Small Vessel Vasculitis Lead Author01-JAN-18 /
Consultant Medical Staff Committee, Cork University Hospital Chair01-SEP-09 / 31-AUG-12
Cardiac Renal Centre Project Team Chair of IT subgroup01-SEP-08 / 31-AUG-11
VINE: The Vasculitis Irish Network. Founder and Member01-JAN-15 /
Royal College of Physicians of Ireland Member/
Department of Renal Medicine, Cork University Hospital Clinical Lead01-JAN-15 /
Executive Management Board, Cork University Hospital. Member01-SEP-09 / 31-AUG-12
Executive Management Board, Cork University Hospital. Member01-SEP-09 / 31-AUG-12

Committees

 CommitteeFunctionFrom / To
Organising Committee of the 20th International Vasculitis and ANCA Workshop to be held in Ireland in 2021 Chair/
College of Medicine and Health (CoMH) Research Committee Founder and Vice Dean for RI2019 /
Cost Control Committee, Cork University Hospital. Member2012 / 2016
Consultant Medical Staff Committee, Cork University Hospital. Chair2009 / 2012

Contact details

  • Michael Clarkson
    Consultant Nephrologist and Senior Clinical Lecturer, CUH, and Vice Dean for Research and Innovation, College of Medicine and Health, UCC.
  • M.Clarkson@ucc.ie
  • Cork University Hospital
    Wilton
    Cork
    Ireland

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College of Medicine and Health

Coláiste an Leighis agus na Sláinte

3rd Floor, Erinville Hospital Western Road University College Cork Cork , T12 EKDO

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