Dr Toulouse was appointed as College Lecturer in Clinical Anatomy and Principal Investigator in the Department of Anatomy and Neuroscience in September 2005. He has taught a vast array of topics related to anatomy and neuroscience and is currently teaching topographical anatomy, human development and molecular neuroscience to students in medicine, dentistry, clinical therapies and neuroscience. In 2008, he completed a post-graduate certificate in Teaching and Learning in Higher Education (UCC) followed by a post-graduate diploma in the same discipline in 2009.
His research is focused on the development of cellular models for the study of the molecular mechanisms of neurodegeneration in polyglutamine disorders and the role of retinoic acid in brain cancer biology. Through his work as an educator, Dr Toulouse has also developed an expertise in the creation and assessment of teaching tools in neuroanatomy and dental anatomy. In addition, Dr Toulouse is the Director of the Biosciences Imaging Centre, an advanced microscopy facility, at University College Cork. His work has been funded through personal fellowships from the Fonds pour la Formation des Chercheurs et l'Aide à la Recherche and the Fonds de la Recherche en Santé du Québec as well as research grants from the Health Research Board of Ireland, Science Foundation Ireland, the National Forum for Teaching and Learning, and the Irish Research Council for Science, Engineering and Technology.
Over the years, I have taught a wide variety of subjects (systematic and topographical anatomy, embryology and developmental anatomy, molecular biology, genetics, molecular and cellular neuroscience, research methods, neuroanatomy) to students from various disciplines (dental hygiene, dentistry, medicine, nursing, clinical therapies, sport studies and education, pharmacy, biological sciences and neuroscience). In addition to developing and updating lecture content, I have established new modules for the B.Ed. in Sports Studies and Education (AN1063) and student selected modules for the medical degree (AN2062 and AN3000). I have re-designed all the modules that I currently coordinate, teach and examine (AN1004, AN1006, AN2006, AN2007, AN2008, AN2060, AN2061, AN2062, AN3000, AN3009, and AN3011). In addition, I contribute to teaching and examination on the following modules: AN3013, AN4010, FM1010, FM1020, FM1030, FM1040, FM2102, MH1010, MH1020, MH1030, MH1040, MH2102, GM1002 and MX1009.
Undergraduate research projects
I have surpervised a large number of undergraduate research projects and literature reviews from a variety of disciplines including the B.Sc. Neuroscience literature review (AN3011) and research projects (AN4010), B.Sc. Genetics literature review (GN3002) and research projects (GN4002), as well as medical degree research projects (MX1006 and MX5090).
Post-graduate teaching
At post-graduate level, I contribute teaching to the M.Sc in Molecular Cell Biology with Bioinnovation (ML6002) and the M.Sc in Obstetrics and Gynaecology (OG6001 and OG6005). In addition, I deliver the content for module AN6012 - Human Embryology to students in the MSc Human Anatomy programme.
Biography
André Toulouse received a BSc degree in Biology from Université Laval (Québec, Canada) in 1991. He developed his expertise in cellular and molecular biology of diseases by completing a MSc (1993) and a PhD (1998) in Molecular Biology at Université de Montréal (Montréal, Canada). His work characterized the role of retinoic acid receptors in the suppression of lung cancers. His interest in Neuroscience led him to undertake post-doctoral work with Dr Guy Rouleau in the Centre for Research in Neuroscience at McGill University (Montréal, Canada) where he also worked as a research associate in the Neurogenetics Laboratory. His research areas included the identification and cloning of genes involved in neurodevelopmental disorders and the development of cellular models of neurodegeneration for polyglutamine disorders. In 2003, he moved to University College Cork to pursue post-doctoral work on the molecular biology of neurotrophic factors.Dr Toulouse was appointed as College Lecturer in Clinical Anatomy and Principal Investigator in the Department of Anatomy and Neuroscience in September 2005. He has taught a vast array of topics related to anatomy and neuroscience and is currently teaching topographical anatomy, human development and molecular neuroscience to students in medicine, dentistry, clinical therapies and neuroscience. In 2008, he completed a post-graduate certificate in Teaching and Learning in Higher Education (UCC) followed by a post-graduate diploma in the same discipline in 2009.
His research is focused on the development of cellular models for the study of the molecular mechanisms of neurodegeneration in polyglutamine disorders and the role of retinoic acid in brain cancer biology. Through his work as an educator, Dr Toulouse has also developed an expertise in the creation and assessment of teaching tools in neuroanatomy and dental anatomy. In addition, Dr Toulouse is the Director of the Biosciences Imaging Centre, an advanced microscopy facility, at University College Cork. His work has been funded through personal fellowships from the Fonds pour la Formation des Chercheurs et l'Aide à la Recherche and the Fonds de la Recherche en Santé du Québec as well as research grants from the Health Research Board of Ireland, Science Foundation Ireland, the National Forum for Teaching and Learning, and the Irish Research Council for Science, Engineering and Technology.
Research Interests
The role of retinoic acid signalling in brain tumours.
Retinoic acid, a derivative of vitamin A, is a potent signalling molecule in the development of the nervous system. It is responsible for the spatial determination of specific regions of the brain and spinal cord and the terminal differentiation of precursor cells into neural tissue. Studies have shown that specific gene defects in its signalling pathways participate in the development of tumours in a number of tissues, including lung, oesophagus, colorectal and blood. Using a combination of bioinformatics and cell culture models, we are studying the role of various members of the retinoic acid signalling pathway in the development of brain tumours. The identification of specific proteins involved in cancer development allows us to use targeted synthetic drugs to efficiently reduce the growth of cells in vitro.
Development of cellular models for the study of neurodegeneration and neuroprotection.
The exact nature of cell death mechanisms remains unclear for a large proportion of neurological disorders. Despite the identification of causative genes and chemical agents, the reason why certain neurons are more sensitive to insult than others remains elusive. In addition, despite intensive research efforts, symptomatic treatments often have limited efficiency and cannot prevent further degeneration and progression of the disease. Neuroprotective strategies are being developed, which combined with symptomatic treatment could improve the disease outcomes for patients. Using cell culture models, we replicate important steps in the neurodegenerative process, manipulate them, using drugs and neuroprotective factors, and aim to identify the genes that are responsible for neuronal cell death or that could be used to prevent this process. Mechanisms of neurodegeneration in CAG trinucleotide repeat expansion disorders The polyglutamine disorders are a group of neurodegenerative disorders caused by the expansion of a coding CAG trinucleotide repeat and include some of the autosomal dominant spinocerebellar ataxias and Huntington’s disease. Although the causative proteins are widely expressed, these disorders are characterized by the degeneration of specific neuronal populations. Several hypotheses have been proposed to explain degeneration, including transcriptional impairment, altered protein interactions, direct polyglutamine toxicity and accumulation of toxic protein by-products following the alteration of the protein degradation pathways but no unifying mechanism has emerged yet. We have identified a new mechanism of cell toxicity in these disorders where aberrant decoding through ribosomal frameshifting results in the production of highly toxic polyalanine-containing peptides. Recent studies suggest that this mechanism may be involved in many disorders and may be caused by RNA secondary structures, depletion of specific amino acids and the cell’s metabolic rate. Our current studies aim at refining these findings and to further study the mechanism by which the ribosome changes its translational frame. We are developing a cellular model that will allow us to manipulate the translational shifting and explore how cell toxicity can be modulated, identifying potential therapeutic strategies.
Anatomy and Education Research.
Over the past two decades, the number of teaching hours dedicated to the anatomical sciences has been massively reduced in the health sciences curricula, consequently, students are reporting difficulties with the discipline. In addition, limitations in preparing and retaining appropriate anatomical models have further contributed to the increased perception that anatomy is a difficult subject. In recent years, we have developed and assessed a number of educational tools (animations, online resources, 3D computer quiz) to supplement teaching and consolidate learning in the areas of dental anatomy and neuroanatomy. In collaboration with the dissection room technical team, we are interested in exploring new ways of maximizing the use of cadaveric material for teaching and have uncovered a number of rare anatomical variations.
Lab Members and Alumni
Post-Doctoral Fellows
Dr David O'Sullivan (2005-2006)
Embryonic stem cells for Parkinson's disease
Ph.D. Students
Grace Collins (2007-2012)
Generation of suicide-gene system for cell replacement therapy
Louise Collins (2008-2013)
The role of mitogen activated protein kinase phosphatase-1 in neurotoxic and inflammatory-induced changes in the development of midbrain dopaminergic neurons: Relevance to Parkinson's disease
Mutahira Lone (2014-2017)
Development and assessment of teaching resources for dental anatomy
Muhammad Asim Javaid (2015-2019)
Development of web-based clinically oriented blended learning tools for neuroanatomy
Patricia Flynn (2021-present)
Identification of therapeutically relevant tumour-associated alterations of the RA signalling pathway in glioblastoma
M.Sc. Students
Emma McDonnell (2005-2006)
Sub-cloning and expression analysis of the Ki-67 promoter
Lorna Farrelly (2009-2010)
In vitro / in vivo modulation of the neuropeptide Y (NPY) system by antiepileptic and antidepressive drugs
Ian O'Brien (2010-2012)
Transcription factor regulation of dopaminergic neural stem cell fate in an inflammatory environment
Tony Blake (2015)
Microarray profiling of neurotrophic signalling in Parkinson's disease
Melissa Grant Hanni (2016)
Neurotrophic signalling pathways in models of Parkinson's disease
John O’Sullivan (2018)
The role of retinoic acid receptors in glioma growth suppression
Carrie O’Flynn (2018-2021)
Development of a Cadaver-based Teaching Model for Oral Anatomy
Patricia Flynn (2018-2021)
Deciphering the role of the retinoic acid pathway in glioma
Meghan Loftus (2020)
Renal vein variations and the prevalence of double inferior vena cava and horseshoe kidney
Mark Walsh (2021)
Deciphering the role of isoform-specific retinoids in glioblastoma
Mawadda Mohamed (2021)
Perrine Chapotot (2009, Ecole Polytechnique Lasalle, Beauvais, France
Ian O'Brien (2009, Health Research Board Summer Vacation Research Scholarship)
Amandine Even (2014, Universite de Nantes, Nantes, France)
Ingrid Lager Gotaas (2015, Wellcome Trust Biomedical Vacation Scholarship)
Ingrid Lager Gotaas (2016, Anatomical Society Undergraduate Summer Vacation Research Scholarship)
Undergraduate Final Year Students
2005/2006: Niamh Daly, Raymond O’Sullivan
2006/2007: John Williams, Hazel O’Shea, Aoife Kiely
2007/2008: Lisa Caplice, Aoife Healy, Nicole Scully, Michael Lynch
2008/2009: David Andrew, Sean Crampton, Rhona Hyland
2009/2010: Ian O’Brien, Peter Bourke, Piaras O’Murchu
2010/2011: Conor Murphy, Katherine Turner
2011/2012: Darren Coughlan, Cian Dolan
2012/2013: Amy Cole, Laura Kenny
2013/2014: Rachel Furlong, Eimear O’Leary
2014/2015: Jessica Brophy, Patrick Hennessy
2015/2016: Rachael Murray, Jennifer Redmond
2016/2017: Ingrid Lager Gotass, AnnMarie Leen, Alexander Alabi
2017/2018: Patricia Flynn, Ellen O’Hanlon
2018/2019: Jessica Aigbologa, Erica Field
2019/2020: Domynika Januleviciute, Meabh Humphreys
2020/2021: Aaron Dolan, Jessica Pietrzyk
2021/2022: Joseph Brown, Nav Jalan, Emeka Mapoma, Jolie Morisho
Retinoic acid, a derivative of vitamin A, is a potent signalling molecule in the development of the nervous system. It is responsible for the spatial determination of specific regions of the brain and spinal cord and the terminal differentiation of precursor cells into neural tissue. Studies have shown that specific gene defects in its signalling pathways participate in the development of tumours in a number of tissues, including lung, oesophagus, colorectal and blood. Using a combination of bioinformatics and cell culture models, we are studying the role of various members of the retinoic acid signalling pathway in the development of brain tumours. The identification of specific proteins involved in cancer development allows us to use targeted synthetic drugs to efficiently reduce the growth of cells in vitro.
Development of cellular models for the study of neurodegeneration and neuroprotection.
The exact nature of cell death mechanisms remains unclear for a large proportion of neurological disorders. Despite the identification of causative genes and chemical agents, the reason why certain neurons are more sensitive to insult than others remains elusive. In addition, despite intensive research efforts, symptomatic treatments often have limited efficiency and cannot prevent further degeneration and progression of the disease. Neuroprotective strategies are being developed, which combined with symptomatic treatment could improve the disease outcomes for patients. Using cell culture models, we replicate important steps in the neurodegenerative process, manipulate them, using drugs and neuroprotective factors, and aim to identify the genes that are responsible for neuronal cell death or that could be used to prevent this process. Mechanisms of neurodegeneration in CAG trinucleotide repeat expansion disorders The polyglutamine disorders are a group of neurodegenerative disorders caused by the expansion of a coding CAG trinucleotide repeat and include some of the autosomal dominant spinocerebellar ataxias and Huntington’s disease. Although the causative proteins are widely expressed, these disorders are characterized by the degeneration of specific neuronal populations. Several hypotheses have been proposed to explain degeneration, including transcriptional impairment, altered protein interactions, direct polyglutamine toxicity and accumulation of toxic protein by-products following the alteration of the protein degradation pathways but no unifying mechanism has emerged yet. We have identified a new mechanism of cell toxicity in these disorders where aberrant decoding through ribosomal frameshifting results in the production of highly toxic polyalanine-containing peptides. Recent studies suggest that this mechanism may be involved in many disorders and may be caused by RNA secondary structures, depletion of specific amino acids and the cell’s metabolic rate. Our current studies aim at refining these findings and to further study the mechanism by which the ribosome changes its translational frame. We are developing a cellular model that will allow us to manipulate the translational shifting and explore how cell toxicity can be modulated, identifying potential therapeutic strategies.
Anatomy and Education Research.
Over the past two decades, the number of teaching hours dedicated to the anatomical sciences has been massively reduced in the health sciences curricula, consequently, students are reporting difficulties with the discipline. In addition, limitations in preparing and retaining appropriate anatomical models have further contributed to the increased perception that anatomy is a difficult subject. In recent years, we have developed and assessed a number of educational tools (animations, online resources, 3D computer quiz) to supplement teaching and consolidate learning in the areas of dental anatomy and neuroanatomy. In collaboration with the dissection room technical team, we are interested in exploring new ways of maximizing the use of cadaveric material for teaching and have uncovered a number of rare anatomical variations.
Lab Members and Alumni
Post-Doctoral Fellows
Dr David O'Sullivan (2005-2006)
Embryonic stem cells for Parkinson's disease
Ph.D. Students
Grace Collins (2007-2012)
Generation of suicide-gene system for cell replacement therapy
Louise Collins (2008-2013)
The role of mitogen activated protein kinase phosphatase-1 in neurotoxic and inflammatory-induced changes in the development of midbrain dopaminergic neurons: Relevance to Parkinson's disease
Mutahira Lone (2014-2017)
Development and assessment of teaching resources for dental anatomy
Muhammad Asim Javaid (2015-2019)
Development of web-based clinically oriented blended learning tools for neuroanatomy
Patricia Flynn (2021-present)
Identification of therapeutically relevant tumour-associated alterations of the RA signalling pathway in glioblastoma
M.Sc. Students
Emma McDonnell (2005-2006)
Sub-cloning and expression analysis of the Ki-67 promoter
Lorna Farrelly (2009-2010)
In vitro / in vivo modulation of the neuropeptide Y (NPY) system by antiepileptic and antidepressive drugs
Ian O'Brien (2010-2012)
Transcription factor regulation of dopaminergic neural stem cell fate in an inflammatory environment
Tony Blake (2015)
Microarray profiling of neurotrophic signalling in Parkinson's disease
Melissa Grant Hanni (2016)
Neurotrophic signalling pathways in models of Parkinson's disease
John O’Sullivan (2018)
The role of retinoic acid receptors in glioma growth suppression
Carrie O’Flynn (2018-2021)
Development of a Cadaver-based Teaching Model for Oral Anatomy
Patricia Flynn (2018-2021)
Deciphering the role of the retinoic acid pathway in glioma
Meghan Loftus (2020)
Renal vein variations and the prevalence of double inferior vena cava and horseshoe kidney
Mark Walsh (2021)
Deciphering the role of isoform-specific retinoids in glioblastoma
Mawadda Mohamed (2021)
Assessment of the online teaching of a dental morphology module during Covid-19 pandemic
Kenneth Osuji (2021)
Kenda Samman (2021)
Anatomical variations of the renal blood supply, a cadaveric study and review of the literature
B.Sc. InternshipsKenneth Osuji (2021)
Comparison of the preservative properties of hard and soft fixatives for orbital and ocular anatomical structures
Kenda Samman (2021)
Anatomical variations of the renal blood supply, a cadaveric study and review of the literature
Perrine Chapotot (2009, Ecole Polytechnique Lasalle, Beauvais, France
Ian O'Brien (2009, Health Research Board Summer Vacation Research Scholarship)
Amandine Even (2014, Universite de Nantes, Nantes, France)
Ingrid Lager Gotaas (2015, Wellcome Trust Biomedical Vacation Scholarship)
Ingrid Lager Gotaas (2016, Anatomical Society Undergraduate Summer Vacation Research Scholarship)
Undergraduate Final Year Students
2005/2006: Niamh Daly, Raymond O’Sullivan
2006/2007: John Williams, Hazel O’Shea, Aoife Kiely
2007/2008: Lisa Caplice, Aoife Healy, Nicole Scully, Michael Lynch
2008/2009: David Andrew, Sean Crampton, Rhona Hyland
2009/2010: Ian O’Brien, Peter Bourke, Piaras O’Murchu
2010/2011: Conor Murphy, Katherine Turner
2011/2012: Darren Coughlan, Cian Dolan
2012/2013: Amy Cole, Laura Kenny
2013/2014: Rachel Furlong, Eimear O’Leary
2014/2015: Jessica Brophy, Patrick Hennessy
2015/2016: Rachael Murray, Jennifer Redmond
2016/2017: Ingrid Lager Gotass, AnnMarie Leen, Alexander Alabi
2017/2018: Patricia Flynn, Ellen O’Hanlon
2018/2019: Jessica Aigbologa, Erica Field
2019/2020: Domynika Januleviciute, Meabh Humphreys
2020/2021: Aaron Dolan, Jessica Pietrzyk
2021/2022: Joseph Brown, Nav Jalan, Emeka Mapoma, Jolie Morisho
Research Grants
| Project | Funding Body | Start Date | End Date | Award | |
|---|---|---|---|---|---|
| Identification of therapeutically relevant tumour-associated alterations of the RA signalling pathway in glioblastoma | Breakthrough Cancer Research | 01-OCT-21 | 30-SEP-24 | €119,800.00 | |
| Characterisation of serum and cerebrospinal fluid biomarkers of angiographic cerebral vasospasm (ACV) and delayed cerebral ischemia (DCI) in aneurysmal subarachnoid haemorrhage | College of Medicine & Health | 01-OCT-19 | 30-SEP-20 | €10,000.00 | |
| Characterisation of tissue and blood biomarkers of response and progression in a murine model of melanoma brain metastasis following treatment with a combination of Nivolumab and Ipilimumab. | UCC TRAP (Translational Research Access Programme) | 01-NOV-17 | 30-SEP-18 | €10,000.00 | |
| Deployment of advanced microscopy equipment | Science Foundation Ireland | 01-JUN-17 | 31-MAY-18 | €85,246.00 | |
| Upgrade of confocal imaging facilities | Science Foundation Ireland | 01-JAN-17 | 01-DEC-17 | €57,921.00 | |
| Anatomy-Physiology for Dental Science | The National Forum for the Enhancement of Teaching and Learning in Higher Education | 22-FEB-16 | 31-DEC-16 | €5,000.00 | |
| Retinoic acid receptor expression in gliomas | UCC TRAP (Translational Research Access Programme) | 04-JAN-16 | 31-DEC-16 | €10,000.00 | |
| Investigation of Morphological and Functional Aspects of Syncytiotrophblast Nuclear Organization Patterns in the Human Placenta | Foreign Research Institute | 20-JUN-16 | 26-AUG-16 | €2,800.00 | |
| Effect of the dual-specificity phosphatase MKP1 on neuronal cell survival and differentiation. | Wellcome Trust | 29-JUN-15 | 28-AUG-15 | €2,816.00 | |
| Investigation of Morphological and Functional Aspects of Syncytiotrophoblast Nuclear Organization Patterns in the Human Placenta. | UCC TRAP (Translational Research Access Programme) | 01-JUN-13 | 30-JUN-14 | €6,000.00 | |
| Transcription factor regulation of dopaminergic neural stem cell fate in an inflammatory environment | Irish Research Council | 01-OCT-10 | 30-JUN-12 | €72,000.00 | |
| Embryonic Stem Cells for Parkinson's Disease | Health Research Board | 08-JUN-09 | 31-JUL-09 | €2,000.00 | |
| Embryonic Stem Cells for Parkinson's Disease | Health Research Board | 01-OCT-06 | €32,667.00 | ||
| Embryonic Stem Cells for Parkinson's Disease | Health Research Board | 01-OCT-05 | 30-SEP-10 | €202,568.00 |
Publications
Book Chapters
| Year | Publication | |
|---|---|---|
| (2012) | 'Inflammation in Parkinson's disease: causes and consequences' Collins L.M., Toulouse A., Nolan Y.M. (2012) 'Inflammation in Parkinson's disease: causes and consequences' In: Mechanisms in Parkinson's Disease - Models and Treatments. Croatia: InTech. [Full Text] [Details] | |
| (2011) | 'The potential of Neurotrophic Factors for the Treatment of Parkinson's Disease' Sullivan A.M., Toulouse A. (2011) 'The potential of Neurotrophic Factors for the Treatment of Parkinson's Disease' In: Towards New Therapies for Parkinson's Disease. Croatia: InTech. [Full Text] [Details] | |
| (1997) | 'Retinoic Acid Receptor beta: An Exploration of its Role in Lung Cancer Suppression and its Potential in Cancer Prevention' Toulouse A., Morin J., Ying Y., Ayoub J., Bradley W.E.C. (1997) 'Retinoic Acid Receptor beta: An Exploration of its Role in Lung Cancer Suppression and its Potential in Cancer Prevention' In: Clinical and Biological Basis of Lung Cancer Prevention. Basel, Switzerland: Birkhäuser-Verlag. [Details] |
Peer Reviewed Journals
| Year | Publication | |
|---|---|---|
| (2021) | 'The utility of plasma circulating cell-free messenger RNA as a biomarker of glioma: a pilot study' Ita M.I., Wang, J.H., Toulouse A., Lim C., Fanning N., O'Sullivan M., Nolan Y., Kaar G.F., Redmond H.P. (2021) 'The utility of plasma circulating cell-free messenger RNA as a biomarker of glioma: a pilot study'. Acta neurochirurgica, [DOI] [Details] | |
| (2021) | 'Development of an online tooth morphology course in response to COVID-19 restrictions' Lone M., Mohamed M.A.A., Toulouse A. (2021) 'Development of an online tooth morphology course in response to COVID-19 restrictions'. Journal of Dental Education, [DOI] [Details] | |
| (2021) | 'eNEUROANAT-CF: a Conceptual Instructional Design Framework for Neuroanatomy e-Learning Tools' Javaid M.A., Schellekens H., Cryan J.F., Toulouse A. (2021) 'eNEUROANAT-CF: a Conceptual Instructional Design Framework for Neuroanatomy e-Learning Tools'. Medical Science Educator, 31 :777-785 [DOI] [Details] | |
| (2020) | 'Evaluation of Neuroanatomy Web Resources for Undergraduate Education: Educators’ and Students’ Perspectives' Javaid M., Schellekens H., Cryan J.F., Toulouse A. (2020) 'Evaluation of Neuroanatomy Web Resources for Undergraduate Education: Educators’ and Students’ Perspectives'. Anatomical Sciences Education, 13 (2):237-249 [DOI] [Details] | |
| (2020) | 'Neuroanatomy of the spinal pathways: evaluation of an interactive multimedia e-learning resource' Javaid, Muhammad Asim; Schellekens, Harriët; Cryan, John F.; Toulouse André (2020) 'Neuroanatomy of the spinal pathways: evaluation of an interactive multimedia e-learning resource'. MedEdPublish, :1-23 [DOI] [Full Text] [Details] | |
| (2019) | 'Development and Assessment of a 3D Tooth Morphology Quiz for Dental Students' Lone M., Vagg T., Theocharopoulos A., Cryan J.F., McKenna J.P., Downer E., Toulouse A. (2019) 'Development and Assessment of a 3D Tooth Morphology Quiz for Dental Students'. Anatomical Sciences Education, 12 :284-299 [DOI] [Full Text] [Details] | |
| (2018) | 'Fossilized skin reveals coevolution with feathers and metabolism in feathered dinosaurs' McNamara M.E., Zhang F., Kearns S.L., Orr P.J., Toulouse A., Foley T., Hone D.W.E., Rogers C.S., Benton M.J., Johnson D., Xu X., Zhou Z. (2018) 'Fossilized skin reveals coevolution with feathers and metabolism in feathered dinosaurs'. Nature Communications, 9 (2072):1-7 [DOI] [Full Text] [Details] | |
| (2018) | 'A Survey of tooth morphology teaching methods employed in the United Kingdom and Ireland' Lone M., McKenna JP., Cryan J.F., Downer E.J., Toulouse A. (2018) 'A Survey of tooth morphology teaching methods employed in the United Kingdom and Ireland'. European Journal Of Dental Education : Official Journal Of The Association For Dental Education In Europe, [DOI] [Details] | |
| (2018) | 'Evaluation of an animation tool developed to supplement dental student study of the cranial nerves' Lone M., McKenna J.P., Vagg T., Cryan J.F., Toulouse A., Downer E.J. (2018) 'Evaluation of an animation tool developed to supplement dental student study of the cranial nerves'. European Journal Of Dental Education : Official Journal Of The Association For Dental Education In Europe, [DOI] [Details] | |
| (2018) | 'Understanding neurophobia: Reasons behind impaired understanding and learning of neuroanatomy in cross-disciplinary healthcare students' Javaid M.A., Chakraborty S., Cryan J.F., Schellekens H., Toulouse A. (2018) 'Understanding neurophobia: Reasons behind impaired understanding and learning of neuroanatomy in cross-disciplinary healthcare students'. Anatomical Sciences Education, 11 (1):81-93 [DOI] [Details] | |
| (2017) | 'Assessment of Thiel-embalmed cadavers as a teaching tool for oral anatomy and local anesthesia' Lone M., McKenna J.P., Balta J.Y., O'Mahony S.M., Cryan J.F., Downer E.J., Toulouse A. (2017) 'Assessment of Thiel-embalmed cadavers as a teaching tool for oral anatomy and local anesthesia'. Journal of Dental Education, 81 (4):420-427 [DOI] [Details] | |
| (2015) | 'A Role for mitogen-activated protein kinase phosphatase 1(MKP1) in neural cell development and survival' Toulouse A., Nolan Y.M. (2015) 'A Role for mitogen-activated protein kinase phosphatase 1(MKP1) in neural cell development and survival'. Neural Regeneration Research, 10 (11):1748-1749 [DOI] [Details] | |
| (2015) | 'RNAi therapeutics for brain cancer: current advancements in RNAi delivery strategies' Malhotra M., Toulouse A., Godhino B.M.D.C., McCarthy D.J., Cryan J.F., O'Driscoll C.M. (2015) 'RNAi therapeutics for brain cancer: current advancements in RNAi delivery strategies'. Molecular Biosystems, 11 :2635-2657 [DOI] [Details] | |
| (2015) | 'Mitogen-Activated Protein Kinase Phosphatase (MKP)-1 in Nervous System Development and Disease' Collins L.M., Downer E.J., Toulouse A., Nolan Y.M. (2015) 'Mitogen-Activated Protein Kinase Phosphatase (MKP)-1 in Nervous System Development and Disease'. Molecular Neurobiology, 51 (June):1158-1167 [DOI] [Details] | |
| (2014) | 'Expression of endogenous Mkp1 in 6-OHDA rat models of Parkinson’s disease' Collins L.M., Gavin A.M., Walsh S., Sullivan A.M., Wyatt S.L., O’Keeffe G.W., Nolan Y.M, Toulouse A. (2014) 'Expression of endogenous Mkp1 in 6-OHDA rat models of Parkinson’s disease'. SpringerPlus, :205-206 [DOI] [Full Text] [Details] | |
| (2013) | 'Therapeutic concentrations of valproate but not amitriptyline increase neuropeptide Y (NPY) expression in the human SH-SY5Y neuroblastoma cell line' Farelly L.A., Savage N.T.P., O'Callaghan C., Toulouse A., Yilmazer-Hanke D.M. (2013) 'Therapeutic concentrations of valproate but not amitriptyline increase neuropeptide Y (NPY) expression in the human SH-SY5Y neuroblastoma cell line'. Regulatory Peptides, 186 :123-130 [DOI] [Details] | |
| (2013) | 'Mitogen-Activated Protein Kinase Phosphatase (MKP)-1 as a Neuroprotective Agent: Promotion of the Morphological Development of Midbrain Dopaminergic Neurons' Collins L.M., O'Keeffe G.W., Long-Smith C.M., Wyatt S.L., Sullivan A.M., Toulouse A., Nolan Y.M. (2013) 'Mitogen-Activated Protein Kinase Phosphatase (MKP)-1 as a Neuroprotective Agent: Promotion of the Morphological Development of Midbrain Dopaminergic Neurons'. NeuroMolecular Medicine, 15 (2):435-446 [DOI] [Details] | |
| (2013) | 'The bisulfite genomic sequencing protocol' Pappas J.J., Toulouse A., Bradley W.E.C. (2013) 'The bisulfite genomic sequencing protocol'. Advances in Lung Cancer, 1 (2):21-25 [DOI] [Details] | |
| (2012) | 'Contributions of central and systemic inflammation to the pathophysiology of Parkinson's disease' Collins L.M., Toulouse A., Connor T.J., Nolan Y.M. (2012) 'Contributions of central and systemic inflammation to the pathophysiology of Parkinson's disease'. Neuropharmacology, 62 (7):2154-2168 [DOI] [Full Text] [Details] | |
| (2012) | 'Exposure of foetal neural progenitor cells to IL-1β impairs their proliferation and alters their differentiation - a role for maternal inflammation?' Crampton S.J., Collins L.M., Toulouse A., Nolan Y.M., O'Keeffe G.W. (2012) 'Exposure of foetal neural progenitor cells to IL-1β impairs their proliferation and alters their differentiation - a role for maternal inflammation?'. Journal of Neurochemistry, 120 (6):964-973 [DOI] [Details] | |
| (2012) | 'Neurotrophic Effects of Growth / Differentiation Factor 5 in a Neuronal Cell Line' Toulouse A., Collins G.C., Sullivan A.M. (2012) 'Neurotrophic Effects of Growth / Differentiation Factor 5 in a Neuronal Cell Line'. Neurotoxicity Research, 21 (3):256-265 [DOI] [Full Text] [Details] | |
| (2011) | 'Knockdown of RARB2 Identifies a Dual Role in Cancer' Pappas J.J., Toulouse A., Basik M., Lévesque L., Bradley W.E.C. (2011) 'Knockdown of RARB2 Identifies a Dual Role in Cancer'. Genes Chromosomes and Cancer, 50 :700-714 [DOI] [Details] | |
| (2010) | 'Interleukin-1beta released from lipopolysaccharide-stimulated rat glia contributes to the exacerbation of dopaminergic neuronal death induced by 6-hydroxydopamine' Long-Smith C.M., Collins L.M., Toulouse A., Sullivan A.M., Nolan Y.M. (2010) 'Interleukin-1beta released from lipopolysaccharide-stimulated rat glia contributes to the exacerbation of dopaminergic neuronal death induced by 6-hydroxydopamine'. Journal of Neuroimmunology, 226 :20-26 [DOI] [Details] | |
| (2009) | 'A Modified Protocol for Bisulfite Genomic Sequencing of Difficult Samples' Pappas J.J., Toulouse A., Bradley W.E.C. (2009) 'A Modified Protocol for Bisulfite Genomic Sequencing of Difficult Samples'. Biological Procedures Online, 11 :99-112 [DOI] [Details] | |
| (2008) | 'Progress in Parkinson's disease - Where do we stand?' Toulouse A., Sullivan A.M. (2008) 'Progress in Parkinson's disease - Where do we stand?'. Progress In Neurobiology, :376-392 [DOI] [Details] | |
| (2008) | 'Allelic methylation bias of the RARB2 tumor suppressor gene promoter in cancer' Pappas, JJ;Toulouse, A;Hebert, J;Fetni, R;Bradley, WEC (2008) 'Allelic methylation bias of the RARB2 tumor suppressor gene promoter in cancer'. Genes Chromosomes and Cancer, 47 :978-993 [DOI] [Details] | |
| (2008) | 'TAT-PAX6 protein transduction in neural progenitor cells: a novel approach for generation of dopaminergic neurones in vitro' Spitere, K., Toulouse, A., O’Sullivan, D.B., Sullivan, A.M. (2008) 'TAT-PAX6 protein transduction in neural progenitor cells: a novel approach for generation of dopaminergic neurones in vitro'. Brain Research, 1208 :25-34 [DOI] [Details] | |
| (2008) | 'Mutations in the nervous system-specific HSN2 exon of WNK1 cause hereditary sensory neuropathy type II' Shekarabi M,. Girard N., Riviere J.B., Dion P., Houle M,. Toulouse A., Lafreniere R.G., Vercauteren F., Hince P., Laganiere J., Rochefort D., Faivre L., Samuels M., Rouleau G.A. (2008) 'Mutations in the nervous system-specific HSN2 exon of WNK1 cause hereditary sensory neuropathy type II'. Journal of Clinical Investigation, 118 (7):2496-2505 [DOI] [Details] | |
| (2005) | 'Transgenic expression of an expanded (GCG)(13) repeat PABPN1 leads to weakness and coordination defects in mice. Neurobiology of Disease' Dion P., Shanmugam V., Gaspar C., Messaed C., Meijer I., Toulouse A., Laganiere J., Roussel J., Rochefort D., Laganiere S., Allen C., Karpati G., Bouchard J.P. , Brais B., Rouleau, G.A. (2005) 'Transgenic expression of an expanded (GCG)(13) repeat PABPN1 leads to weakness and coordination defects in mice. Neurobiology of Disease'. Neurobiology of Disease, 18 (3):528-536 [Details] | |
| (2005) | 'Ribosomal frameshifting on MJD-1 transcripts with long CAG tracts' Toulouse A., Au-Yeung F., Gaspar C., Roussel J., Dion, P., Rouleau, G. A. (2005) 'Ribosomal frameshifting on MJD-1 transcripts with long CAG tracts'. Human Molecular Genetics, 14 (18):2649-2660 [DOI] [Details] | |
| (2003) | 'Molecular cloning and characterization of human RAI1, a gene associated with schizophrenia' Toulouse A., Rochefort D., Roussel J., Joober R., Rouleau G.A. (2003) 'Molecular cloning and characterization of human RAI1, a gene associated with schizophrenia'. Genomics, 82 (2):162-171 [Details] | |
| (2000) | 'DRD3 and DAT1 genes in schizophrenia: an association study' Joober R.,Toulouse A., Benkelfat C., Lafreniere R. G., Lal S., Ajroud S., Turecki G., Bloom D., Labelle A., Lalonde P., Alda M., Morgan K., Palmour R., Rouleau G.A. (2000) 'DRD3 and DAT1 genes in schizophrenia: an association study'. Journal of Psychiatric Research, 34 :285-291 [Details] | |
| (2000) | 'Enhancement of lung tumour cell immunogenicity upon transduction of retinoic acid receptor beta' Toulouse A., Loubeau M., Morin J., Pappas J.J., Wu J., Bradley W.E.C. (2000) 'Enhancement of lung tumour cell immunogenicity upon transduction of retinoic acid receptor beta'. Faseb Journal, 14 (9):1224-1232 [Details] | |
| (2000) | 'RAR beta 2 specificity in mediating RA inhibition of growth of lung cancer-derived cells' Toulouse A., Morin J., Dion P.A., Houle B., Bradley W.E.C. (2000) 'RAR beta 2 specificity in mediating RA inhibition of growth of lung cancer-derived cells'. Lung Cancer, 28 (2):127-137 [Details] | |
| (1999) | 'T102C polymorphism in the 5HT2A gene and schizophrenia: relation to phenotype and drug response variability. J Psychiatry Neurosci' Joober R. Benkelfat C., Brisebois K., Toulouse A., Turecki G., Lal S., Bloom D., Labelle A., Lalonde P., Fortin D., Alda M., Palmour R., Rouleau G.A.; (1999) 'T102C polymorphism in the 5HT2A gene and schizophrenia: relation to phenotype and drug response variability. J Psychiatry Neurosci'. J Psychiatry Neurosci, 24 (2):141-146 [Details] | |
| (1999) | 'Analysis of 14 CAG repeat-containing genes in schizophrenia' Joober R., Benkelfat C., Toulouse A., Lafreniere R.G., Lal S., Ajroud S., Turecki G., Bloom D., Labelle A., Lalonde P., Alda M., Morgan K., Palmour R., Rouleau G.A (1999) 'Analysis of 14 CAG repeat-containing genes in schizophrenia'. American Journal of Medical Genetics, 88 (6):694-699 [Details] | |
| (1999) | 'Lack of association between the hSKCa3 channel gene CAG polymorphism and schizophrenia' Joober R., Benkelfat C., Brisebois K., Toulouse A., Lafreniere R.G., Turecki G., Lal S., Bloom D., Labelle A., Lalonde P., Fortin D., Alda M., Palmour R., Rouleau G.A. (1999) 'Lack of association between the hSKCa3 channel gene CAG polymorphism and schizophrenia'. American Journal of Medical Genetics, 88 (2):154-157 [Details] | |
| (1996) | 'Structure of the human retinoic acid receptor beta 1 gene' Toulouse A., Morin J., Pelletier M., Bradley W. E. C. (1996) 'Structure of the human retinoic acid receptor beta 1 gene'. Biochem Biophys Acta, 1309 :1-4 [Details] | |
| (1992) | 'Dissociation of the antimicrobial activity of bacitracin USP from its renovascular effects' Drapeau G., Petitclerc E., Toulouse A., Marceau, F. (1992) 'Dissociation of the antimicrobial activity of bacitracin USP from its renovascular effects'. Antimicrobial Agents and Chemotherapy, 36 (5):955-961 [Details] |
Other Journals
| Year | Publication | |
|---|---|---|
| (2002) | 'Advances in Research on Neurodegeneration. - Book Review' Toulouse A., Rouleau G.A.; (2002) 'Advances in Research on Neurodegeneration. - Book Review' Canadian Journal of Neurological Sciences, 29 (4) . [Details] |
Conference Publications
| Year | Publication | |
|---|---|---|
| (2018) | International Palaeontological Congress (IPC) 5, Paris, France McNamara, M.E., Zhang, F., Kearns, S., Orr, P., Toulouse, A., Foley, T., Hone, D., Rogers, C., Benton, M., Xing, X. (2018) Exceptionally preserved skin structure reveals the coevolution of skin, feathers and metabolism in feathered dinosaurs and early birds International Palaeontological Congress (IPC) 5, Paris, France [Details] | |
| (2017) | Anatomical Society Winter Meeting 2017 Lager Gotaas I., Fives C., McCarthy J., Kenny L., FitzGerald B., Toulouse A. (2017) Morphological Aspects of Syncytiotrophoblast Nuclear Organization Patterns in the Human Placenta Anatomical Society Winter Meeting 2017 Dundee, UK, , 18-DEC-17 - 21-DEC-17 [Details] | |
| (2017) | New Horizons in Medical Research Javaid, M.A., Schellekens H., Cryan J.F., Toulouse A. (2017) Deciphering the limitations of neuroanatomy web-resources – a perspective New Horizons in Medical Research Cork, Ireland, , 07-DEC-17 [Details] | |
| (2017) | Joint Anatomical Society and AAA Summer Meeting 2017 Lone M., Vagg T., Theocharopoulos A., Cryan J.F., McKenna J.P., Downer E.J., Toulouse A. (2017) Assessment of a 3D tooth morphology quiz for dental students Joint Anatomical Society and AAA Summer Meeting 2017 Galway, Ireland, , 27-JUN-17 - 29-JUN-17 [Details] | |
| (2017) | Joint Anatomical Society and AAA Meeting Summer 2017 Javaid M.A., Cryan J.F., Schellekens H., Toulouse A. (2017) Deciphering the limitations of neuroanatomy teaching web-resources – a perspective Joint Anatomical Society and AAA Meeting Summer 2017 Galway, Ireland, , 27-JUN-17 - 29-JUN-17 [Details] | |
| (2017) | INTED 2017 Lone M., Vagg T., Cryan J.F., McKenna JP., Downer E.J.,Toulouse A. (2017) A pipeline to create educational animations for third level education INTED 2017 Valencia, Spain, , 06-MAR-17 - 26-FEB-17 , pp.6227-6233 [Details] | |
| (2017) | INTED 2017 Lone M., Vagg T., Theocharopoulos A., Cryan J.F., Downer E.J., McKenna JP., Toulouse A. (2017) Development of an online tooth morphology 3D Quiz to enhance dental student learning INTED 2017 Valencia, Spain, , 06-MAR-17 - 08-MAR-17 , pp.6153-6160 [Details] | |
| (2016) | New Horizons in Translational Research 2016 Grant Hanni M., Sullivan A.M., Toulouse A. (2016) SHSY-5Y cell model:differentiation and neuroprotection New Horizons in Translational Research 2016 University College Cork, Cork, Ireland, , 08-DEC-16 [Details] | |
| (2016) | New Horizons in Translational Research 2016 Lone M., McKenna J.P., Cryan J.F., Vagg T., Toulouse A., Downer E.J.. (2016) Development and Assessment of a Cranial Nerve Animation to Enhance Dental Student Learning New Horizons in Translational Research 2016 University College Cork, , 08-DEC-16 [Details] | |
| (2016) | New Horizons in Translational Research 2016 Lager Gotaas I., Fives C., McCarthy J., Kenny L., FitzGerald B., Toulouse A. (2016) Morphological Aspects of Syncytiotrophoblast Nuclear Organization Patterns in the Human Placenta New Horizons in Translational Research 2016 , 08-DEC-16 [Details] | |
| (2016) | New Horizons in Translational Research 2016 Javaid M.A., Chakraborty S., Cryan J.F., Schellekens H., Toulouse A. (2016) Understanding Neurophobia: Reasons behind Impaired Understanding and Learning of Neuroanatomy in Cross-Disciplinary Healthcare Students New Horizons in Translational Research 2016 , 08-DEC-16 [Details] | |
| (2016) | Young Neuroscientists Symposium 2016 Grant Hanni M., Sullivan A.M., Toulouse A. (2016) SHSY-5Y cell model:differentiation and neuroprotection Young Neuroscientists Symposium 2016 Trinity College, Dublin. Ireland, , 01-SEP-16 [Details] | |
| (2016) | Experimental Biology Lone M., McKenna J.P., Cryan J.F., Vagg, T., Toulouse A., Downer E.J. (2016) Can a cranial nerve animation enhance Dental student learning? Employing an innovative teaching aid in the classroom Experimental Biology San Diego, CA, USA, , 02-APR-16 - 06-APR-16 [Details] | |
| (2016) | Annual Research Day of the Irish Division of the International Association of Dental Research Lone M., McKenna J.P., Cryan J.F., Vagg, T., Toulouse A., Downer E.J. (2016) Can an animation enhance comprehension of neuroanatomy? Employing an innovative teaching aid in the dental anatomy classroom Annual Research Day of the Irish Division of the International Association of Dental Research Cork, Ireland, , 03-MAR-16 - 04-MAR-16 [Details] | |
| (2016) | Annual Research Day of the Irish Division of the International Association of Dental Research Lone M., McKenna J.P., Cryan J.F., Downer E.J., Toulouse A. (2016) Thiel-embalmed cadavers as clinical teaching tools: a pilot study Annual Research Day of the Irish Division of the International Association of Dental Research Cork, Ireland, , 03-MAR-16 - 04-MAR-16 [Details] | |
| (2015) | New Horizons in Medical Research Toulouse A., Lager Gotaas I. (2015) Alternative ribosomal translation as a pathological mechanism in polyglutamine neurological disorders New Horizons in Medical Research University College Cork, Cork, Ireland, , 10-DEC-15 [Details] | |
| (2015) | New Horizons in Medical Research Lone M., McKenna J.P., Cryan J.F., Vagg, T., Toulouse A., Downer E.J. (2015) Development of a Cranial Nerve Animation to Enhance Dental Student Learning New Horizons in Medical Research University College Cork, Cork, Ireland, , 10-DEC-15 [Details] | |
| (2015) | Better Outcomes for Maternal and Fetal Health Fives C., McCarthy J., Kenny L., Toulouse A., FitzGerald B. (2015) Fine Needle Aspiration - A Novel Tool for Investigating Placental Structural Organization Better Outcomes for Maternal and Fetal Health Cork, Ireland, , 16-JUN-15 - 16-JUN-15 [Details] | |
| (2014) | New Horizons in Medical Research Fives C., McCarthy J., Kenny L., Toulouse A., FitzGerald B. (2014) Fine Needle Aspiration Cytology - A Novel Tool for Investigating Placental Structural Organization New Horizons in Medical Research University College Cork, , 11-DEC-14 [Details] | |
| (2014) | 38th European Cytology Conference Fives C., McCarthy J., Kenny L., Toulouse A., FitzGerald B. (2014) Placental Cytology- A Description of Features and Comparison of Preparations 38th European Cytology Conference Geneva, Switzerland, , 27-SEP-14 - 30-SEP-14 [Details] | |
| (2014) | 38th European Cytology Conference Fives C., McCarthy J., Kenny L., Toulouse A., FitzGerald B. (2014) Placental cytology - A Description of Features and Comparison of Preparations 38th European Cytology Conference Geneva, Switzerland, , 27-SEP-14 - 30-SEP-14 [Details] | |
| (2014) | 60th Pediatric Pathology Society Annual Meeting Fives C., McCarthy J., Kenny L., Toulouse A., FitzGerald B. (2014) Fine Needle Aspiration - A Novel Tool for Investigating Placental Structural Organization 60th Pediatric Pathology Society Annual Meeting Birmingham, UK, , 04-SEP-14 - 06-SEP-14 [Details] | |
| (2010) | 5th Neuroscience Ireland Annual Conference Collins L. M., Toulouse A., Nolan Y. M. (2010) Effect of Interleukin-1b and 6-Hydroxydopamine on MKP-1 Expression in Embryonic Rat Ventral Mesencephalic Precursor Cells 5th Neuroscience Ireland Annual Conference University College Dublin, , 02-SEP-10 - 03-SEP-10 [DOI] [Details] | |
| (2010) | 5th Neuroscience Ireland Annual Conference Farrelly L. A., Toulouse A., Yilmazer-Hanke D. (2010) Effect of Amitriptyline and Sodium Valproate on Neuropeptide Y Expression in the SH-SY5Y cell line 5th Neuroscience Ireland Annual Conference University College Dublin, , 02-SEP-10 - 03-SEP-10 [DOI] [Details] | |
| (2009) | International Conference on Alzheimer's and Parkinson's Diseases Toulouse A., Collins G.C., Sullivan, A.M. (2009) The neurotrophic effects of Growth/Differentiation Factor 5 in a neuronal cell line International Conference on Alzheimer's and Parkinson's Diseases Prague, Czech Republic, , 11-MAR-09 - 15-MAR-09 [Details] | |
| (2006) | Microsat 2006 - 2nd International Tandem Repeat Consortium Workshop Toulouse A., Au-Yeung F., Gaspar C., Roussel J., Dion P. A., Rouleau G.A. (2006) Ribosomal frameshifting in long CAG trinucleotide repeats in neurological disorders Microsat 2006 - 2nd International Tandem Repeat Consortium Workshop Budapest, Hungary, , 08-SEP-06 - 11-SEP-06 [Details] | |
| (2006) | Mechanisms Underlying Emerging Themes in Neurobiology Toulouse A., Gaspar C., Au-Yeung F., Roussel J., Dion P., Rouleau G.A. (2006) Polyglutamine disorders - Slipping to disease Mechanisms Underlying Emerging Themes in Neurobiology Cork, Ireland, , 06-JUN-06 - 07-JUN-06 [Details] | |
| (2005) | Albany 2005: Conversation 14 Rouleau G.A., Toulouse A., Au-Yeung F., Gaspar C., Roussel J., Dion P. A. (2005) Role of Translational Slippage of Long CAG Tracts in Neurological Disorders Albany 2005: Conversation 14 Albany NY, USA, , 14-JUN-05 - 18-JUN-05 [Details] | |
| (2005) | 35th Annual Meeting of the Society for Neuroscience Spitere K., Toulouse A.,Sullivan, A.M. (2005) TAT-PAX6 protein transduction in neural progenitor cells: A novel strategy for dopaminergic neuron generation 35th Annual Meeting of the Society for Neuroscience Wahington DC, USA, , 12-NOV-05 - 16-NOV-05 [Details] | |
| (2005) | 16th International Congress on Parkinson's Disease and Related Disorders Toulouse A., Sullivan A.M. (2005) Investigation of the neurotrophic effects of growth/differentiation factor 5 in an in vitro model of Parkinson's disease 16th International Congress on Parkinson's Disease and Related Disorders Berlin, Germany, , 05-JUN-05 - 09-JUN-05 [Details] | |
| (2004) | Anatomical Society of Great Britain and Ireland Summer Meeting Toulouse A., Sullivan, A.M. (2004) Investigation of the effects of the neurotrophin GDF5 on the growth and differentiation of SHSY-5Y cells Anatomical Society of Great Britain and Ireland Summer Meeting Cork, Ireland, , 06-JUL-04 - 08-JUL-04 [Details] | |
| (2004) | 34th Annual Meeting of the Society for Neuroscience O'Keeffe G.W., Toulouse A., Sullivan A.M. (2004) Dopaminergic induction from expanded rat ventral mesencephalic progenitor cells by GDF5 and BMP2 requires signalling through BMPR1b 34th Annual Meeting of the Society for Neuroscience San Diego CA, USA, , 23-OCT-04 - 27-OCT-04 [Details] | |
| (2004) | 34th Annual Meeting of the Society for Neuroscience Toulouse A., Sullivan, A.M. (2004) Roles of type 1 BMP receptors in the induction of midbrain dopaminergic neurones by GDF5 34th Annual Meeting of the Society for Neuroscience San Diego CA, USA, , 23-OCT-04 - 27-OCT-04 [Details] | |
| (2004) | 4th Forum of European Neuroscience Toulouse A., Sullivan A.M. (2004) Investigation of the role of GDF5 in the growth and differentiation of human neuroblastoma cells 4th Forum of European Neuroscience Lisbon, Portugal, , 10-JUL-04 - 14-JUL-04 [Details] | |
| (2003) | Canadian Genetic Diseases Network Annual Scientific Meeting Toulouse A., Au-Yeung F., Gaspar C., Roussel J., Rouleau G.A. (2003) Translational slippage in long CAG tracts, a potential pathological mechanism in neurological disorders Canadian Genetic Diseases Network Annual Scientific Meeting Kananaskis AB, Canada, , 15-MAY-03 - 18-MAY-03 [Details] | |
| (2002) | 34th European Human Genetics Conference Toulouse A., Gaspar C., Rochefort D., Roussel J., Rouleau G.A. (2002) Polyalanine accumulation and toxicity in a CAG tract disorder, Machado-Joseph Disease 34th European Human Genetics Conference Strasbourg, France, , 25-MAY-02 - 28-MAY-02 [Details] | |
| (2002) | Canadian Genetic Diseases Network Annual Scientific Meeting Gros-Louis F., Toulouse A., Rochefort D., Roussel J., Lachapelle K., Tremblay M., Nagy A., Rouleau G.A. (2002) Development of transgenic mice expressing mutant SOD1 in a cell and tissue specific manner Canadian Genetic Diseases Network Annual Scientific Meeting St-Sauveur, Qc, Canada, , 04-APR-02 - 07-APR-02 [Details] | |
| (2000) | American Epilepsy Society, 54th Annual Meeting Brisebois K., Cossette P., Hand C.K., Toulouse A., Andermann E., Berkovic S.F., Andermann F., Faught E., Kuzniecky, R.I., Donaldsen J.O., Leonberg S.C., Rouleau G.A. (2000) Adult Neuronal Ceroid Lipofucinosis with autosomal dominant transmission (Kuf's disease):suggestion of linkage at the CLN2 locus American Epilepsy Society, 54th Annual Meeting Los Angeles, USA, , 01-DEC-00 - 06-DEC-00 [Details] | |
| (2000) | 8th World Congress on Psychiatric Genetics Joober R., Toulouse A., Benkelfat C., Lal S., Bloom D., Labelle A., Lalonde P., Turecki G., Rozen R., Rouleau G.A. (2000) DRD3 and DAT1 genes in schizophrenia: a pharmacogenetic association study 8th World Congress on Psychiatric Genetics Versailles, France, , 27-AUG-00 - 31-AUG-00 [Details] | |
| (1998) | 3rd Canadian Gene Therapy Conference Toulouse A., Loubeau M., Morin J., Wu J., Bradley W.E.C. (1998) Enhancement of lung tumour immunogenicity upon transduction of retinoic acid receptor beta 3rd Canadian Gene Therapy Conference Montreal, Canada, , 26-JUN-98 - 28-JUN-98 [Details] | |
| (1996) | IASLC Workshop on The Biological Basis of Lung Cancer Prevention Toulouse A., Morin J., Bradley W.E.C. (1996) Overexpression of hRARA1 or hRARB1 in NSCLC cell line CALU-1 does not inhibit its tumorigenic properties IASLC Workshop on The Biological Basis of Lung Cancer Prevention Nancy, France, , 20-OCT-96 - 22-OCT-96 [Details] | |
| (1995) | XXIIème Forum des Jeunes Chercheurs. Société Française de Biochimie et de Biologie Moléculaire Toulouse A., Morin J., Pelletier M., Houle B., Bradley W.E.C. (1995) Clonage et caractérisation du gène humain codant le récepteur B1 de l'acide rétinoïque XXIIème Forum des Jeunes Chercheurs. Société Française de Biochimie et de Biologie Moléculaire Grenoble, France, , 04-JUL-95 - 07-JUL-95 [Details] | |
| (1994) | 44th annual meeting of the American Society of Human Genetics Toulouse A., Morin J., Pelletier M., Bradley W.E.C. (1994) Involvement of the RARB1 and Dlk genes in small cell lung carcinogenesis and in human development 44th annual meeting of the American Society of Human Genetics Montreal, Canada, , 18-OCT-94 - 22-OCT-94 [Details] | |
| (1994) | XXXVIème réunion annuelle du Club de Recherches Cliniques du Québec Toulouse A., Morin J., Pelletier M., Bradley W.E.C. (1994) Implication potentielle des gènes RARB1 et Dlk dans l'embryogénèse et la tumorigénèse humaines XXXVIème réunion annuelle du Club de Recherches Cliniques du Québec [Details] | |
| (1990) | XXXIIème réunion annuelle du Club de Recherches Cliniques du Québec Marceau F., Deblois D., Toulouse A., Bouthillier J. (1990) La Bacitracine U.S.P., un agent antibiotique, est un agent vasoconstricteur agoniste des récepteurs de type 5-HT2 de la 5-Hydroxytryptamine XXXIIème réunion annuelle du Club de Recherches Cliniques du Québec [Details] | |
| (1990) | 13th Scientific Meeting of the International Society for Hypertension Deblois D., Toulouse A., Bouthillier J., Marceau F. (1990) Bacitracin U.S.P. behaves as an agonist of the 5-HT2 type receptors for 5-Hydroxytryptamine (5-HT) in rabbit isolated smooth muscle and in perfused rat and rabbit kidneys 13th Scientific Meeting of the International Society for Hypertension [Details] |
Professional Activities
Honours and Awards
| Year | Title | Awarding Body | |
|---|---|---|---|
| 1992 | Scholarship of Excellence from Fonds pour la Formation des Chercheurs et l'Aide à la Recherche | Fonds pour la Formation des Chercheurs et l'Aide à la Recherche, FCAR | |
| 1993 | Scholarship of Excellence from the Faculty of Graduate Studies of Université de Montréal | Université de Montréal | |
| 1994 | Canderel Doctoral Scholarship from the Montreal Cancer Institute | Montreal Cancer Institute | |
| 1995 | Canderel Doctoral Scholarship from the Montreal Cancer Institute | Montreal Cancer Institute | |
| 1996 | Canderel Doctoral Scholarship from the Montreal Cancer Institute | Montreal Cancer Institute | |
| 1999 | Postdoctoral Research Fellowship | Fonds de Recherche en Santé du Québec, FRSQ | |
| 2000 | Postdoctoral Research Fellowship | Fonds de Recherche en Santé du Québec, FRSQ | |
| 2005 | Best Poster Presentation Award of the 16th International Congress on Parkinson's Disease and Related Disorders. | 16th International Congress on Parkinson's Disease and Related Disorders. |
Professional Associations
| Association | Function | From / To | |
|---|---|---|---|
| Anatomical Society | Member | / | |
| European Federation of Biotechnology | Member | / | |
| Neuroscience Ireland | Member | / |
Committees
| Committee | Function | From / To | |
|---|---|---|---|
| Neuroscience Ireland | Secretary | 2017 / | |
| College of Medicine and Health Library Committee | Represent the School of Medicine | 2015 / | |
| School of Clinical Therapies Curriculum Committee | Module coordinator | 2005 / | |
| School of Medicine Library Committee | Chair | 2005 / | |
| Department of Anatomy and Neuroscience Graduate Studies Committee | Committee member | 2005 / | |
| School of Medicine Quality Review Committee | Committee member | 2013 / 2014 | |
| School of Clinical Therapies Student Affairs Committee | Committee member | 2006 / | |
| B.Sc. Neuroscience Curriculum Committee | Committee member | 2005 / | |
| Neuroscience Ireland | Board member | 2014 / | |
| School of Medicine Curriculum Committee | Departmental representative | 2014 / | |
| Dental School Curriculum Committee | Departmental representative | 2006 / | |
| Department of Anatomy and Neuroscience Curriculum Committee | Chair | 2014 / |
Employment
| Employer | Position | From / To | |
|---|---|---|---|
| University College Cork | College Lecturer in Anatomy | 01-SEP-05 / | |
| Dr Aideen Sullivan, University College Cork | Post-Doctoral Fellow | 01-AUG-03 / 31-AUG-05 | |
| Dr Guy Rouleau, McGill University | Research Associate | 01-JAN-02 / 30-JUN-03 | |
| Dr Guy Rouleau, McGill University | Post-Doctoral Fellow | 14-OCT-97 / 31-DEC-01 |
Education
| Year | Institution | Qualification | Subject | |
|---|---|---|---|---|
| 1991 | Université Laval, Canada | B.Sc. | Biology | |
| 1993 | Université de Montréal, Canada | M.Sc. | Molecular Biology | |
| 1998 | Université de Montréal, Canada | Ph.D. | Molecular Biology | |
| 2008 | University College Cork, Ireland | Postgraduate Certificate in Teaching and Learning in Higher Ed. | Teaching and Learning in Higher Education | |
| 2009 | University College Cork, Ireland | Postgraduate Diploma Teaching & Learning in Higher Education | Teaching and Learning in Higher Education |
Languages
| Language | Reading | Writing | Speaking | |
|---|---|---|---|---|
| English | Fluent | Fluent | Fluent | |
| French | Fluent | Fluent | Fluent |
Outreach Activities
| Description | |
|---|---|
Adjudicator and Advisor for the Debating Science Issues School Competition. | |
Organiser of the art exhibition "1514-2014 - The Legacy of Andreas Vesalius - The art of anatomy in education" presented at the Jennings Gallery in University College Cork from the 21st October to 1st December 2014. | |
Organiser of the symposium "1514-2014 - The Legacy of Andreas Vesalius - Challenging Medical Education", held in University College Cork on the 21st October 2014 to mark the 500th anniversary of the famous anatomist. |
Journal Activities
| Journal | Role | To / From | |
|---|---|---|---|
| Journal Of Pharmacy And Pharmacology | Referee | - | |
| Gene Therapy | Referee | - | |
| Brain Research Bulletin | Referee | - | |
| Aging Cell | Referee | - | |
| Experimental And Molecular Pathology | Referee | - | |
| Aims Neuroscience | Referee | - | |
| Brain Research | Referee | - | |
| Food And Chemical Toxicology | Referee | - | |
| Neural Regeneration Research | Referee | - | |
| The Scientific World Journal | Member of Editorial Board | - | |
| Journal Of Neuroscience Research | Referee | - | |
| Journal Of Biological Chemistry | Referee | - |
Other Activities
| Description | |
|---|---|
2018 - External Examiner MD thesis - Trinity College Dublin | |
2016- 2018 - External Examiner, Dental Council of Ireland | |
2015 - External PhD examiner - Keele University | |
2010, 2011, 2015, 2017 Internal MSc examiner, University College Cork | |
2013 - External PhD examiner - Università degli Studi di Siena | |
2009, Examiner - Postgraduate committee, Department of Physiology, University College Cork | |
2006, 2007, 2009, 2012, 2013, 2016 Internal PhD examiner, University College Cork |
Teaching Activities
Teaching Interests
Undergraduate TeachingOver the years, I have taught a wide variety of subjects (systematic and topographical anatomy, embryology and developmental anatomy, molecular biology, genetics, molecular and cellular neuroscience, research methods, neuroanatomy) to students from various disciplines (dental hygiene, dentistry, medicine, nursing, clinical therapies, sport studies and education, pharmacy, biological sciences and neuroscience). In addition to developing and updating lecture content, I have established new modules for the B.Ed. in Sports Studies and Education (AN1063) and student selected modules for the medical degree (AN2062 and AN3000). I have re-designed all the modules that I currently coordinate, teach and examine (AN1004, AN1006, AN2006, AN2007, AN2008, AN2060, AN2061, AN2062, AN3000, AN3009, and AN3011). In addition, I contribute to teaching and examination on the following modules: AN3013, AN4010, FM1010, FM1020, FM1030, FM1040, FM2102, MH1010, MH1020, MH1030, MH1040, MH2102, GM1002 and MX1009.
Undergraduate research projects
I have surpervised a large number of undergraduate research projects and literature reviews from a variety of disciplines including the B.Sc. Neuroscience literature review (AN3011) and research projects (AN4010), B.Sc. Genetics literature review (GN3002) and research projects (GN4002), as well as medical degree research projects (MX1006 and MX5090).
Post-graduate teaching
At post-graduate level, I contribute teaching to the M.Sc in Molecular Cell Biology with Bioinnovation (ML6002) and the M.Sc in Obstetrics and Gynaecology (OG6001 and OG6005). In addition, I deliver the content for module AN6012 - Human Embryology to students in the MSc Human Anatomy programme.
Research Information
Internal Collaborators
| Name | Institute | Country | |
|---|---|---|---|
| Dr Collette Hand | University College Cork | IRELAND | |
| Dr Yvonne Nolan | University College Cork | IRELAND | |
| Dr Aideen Sullivan | University College Cork | IRELAND |
External Collaborators
| Name | Organisation / Institute | Country | |
|---|---|---|---|
| Dr Niamh Bermingham | Neuropathology department, Cork University Hospital | IRELAND | |
| Dr Brendan FitzGerald | Cork University Hospital | IRELAND | |
| Dr Cassie Fives | Cork University Hospital | IRELAND | |
| Dr Michael Jansen | Neuropathology department, Cork University Hospital | IRELAND | |
| Dr Guy Rouleau | Montreal Neurological Institute | CANADA |