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4. Jane English

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Biography

Jane received her PhD in Molecular Psychiatry and Proteomics from the Royal College of Surgeons in Ireland (RCSI) in 2008. Jane subsequently joined the M.J. Dunn laboratory as a post-doctoral researcher at the University College Dublin (UCD) Conway Institute, where she developed proteomic methods to study biologically relevant sub-proteomes in post-mortem brain from patients with Schizophrenia. In 2013, Jane took on the role of Programme Manager for a HRB funded Biomarker Discovery Programme in Psychosis in the DR Cotter laboratory, RCSI. In this capacity, her research focused on using mass spectrometry based -discovery and -targeted workflows to identify and verify blood-based protein biomarkers which predict the onset of psychotic disorder in children with “at risk mental state”. In 2017, Jane was awarded a Science Foundation Ireland - Industry Fellowship to gain industry experience in personalised diagnostics and the development of commercial biomarker assays at Inform Bioscience Ltd., Co. Cork; http://www.informbio.com/. In 2017, Jane was awarded a prestigious Health Research Board -Emerging Investigator Award and is the Principal Investigator of a Biomarker Discovery Programme in Autism Spectrum Disorder, at INFANT http://www.infantcentre.ie/. In 2018, Jane was appointed Lecturer in the Department of Anatomy and Neuroscience, UCC; https://www.ucc.ie/en/anatomy/. For full publication metrics visit google scholar https://scholar.google.com/citations?user=h7x0IQoAAAAJ&hl=en.‍

Research Interests

Dr English’s research focuses on the application of proteomics, bioinformatics, and systems biology approaches to study molecular pathways implicated in human health and disease, with a focus on neurodevelopmental and neuropsychiatric disorders.

Research Grants

	Project	Funding Body	Start Date	End Date	Award
	Biomarker Discovery in Ultra High Risk for Psychosis: towards prediction of psychotic disorder, non-psychotic mental disorders and recovery.	Health Research Board	01-FEB-18		€370,000.00
	BIOMARKER VERIFICATION AND VALIDATION FOR PREECLAMPSIA	Science Foundation Ireland	01-MAY-17	01-MAR-18	€53,831.00
	Iron regulation in the brain and its relationship to myelin pathology in schizophrenia	Health Research Board	01-OCT-10		€285,000.00
	“Biomarker Discovery and Validation in Autism Spectrum Disorder	Health Research Board	01-APR-18	01-APR-22	€800,000.00

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Publications

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Peer Reviewed Journals

	Year	Publication
	(2018)	'Blood-Based Protein Changes in Childhood Are Associated With Increased Risk for Later Psychotic Disorder: Evidence From a Nested Case-Control Study of the ALSPAC Longitudinal Birth Cohort' English JA;Lopez LM;O'Gorman A;Föcking M;Hryniewiecka M;Scaife C;Sabherwal S;Wynne K;Dicker P;Rutten BPF;Lewis G;Zammit S;Cannon M;Cagney G;Cotter DR; (2018) 'Blood-Based Protein Changes in Childhood Are Associated With Increased Risk for Later Psychotic Disorder: Evidence From a Nested Case-Control Study of the ALSPAC Longitudinal Birth Cohort'. Schizophrenia bulletin, 44 (2) [DOI] [Details]
	(2016)	'Dataset of mouse hippocampus profiled by LC-MS/MS for label-free quantitation' English JA;Scaife C;Harauma A;Focking M;Wynne K;Cagney G;Moriguchi T;Cotter DR; (2016) 'Dataset of mouse hippocampus profiled by LC-MS/MS for label-free quantitation'. Data In Brief, 7 [DOI] [Details]
	(2016)	'Dysregulation of miRNA-9 in a Subset of Schizophrenia Patient-Derived Neural Progenitor Cells' Topol A;Zhu S;Hartley BJ;English J;Hauberg ME;Tran N;Rittenhouse CA;Simone A;Ruderfer DM;Johnson J;Readhead B;Hadas Y;Gochman PA;Wang YC;Shah H;Cagney G;Rapoport J;Gage FH;Dudley JT;Sklar P;Mattheisen M;Cotter D;Fang G;Brennand KJ; (2016) 'Dysregulation of miRNA-9 in a Subset of Schizophrenia Patient-Derived Neural Progenitor Cells'. Cell Reports, 15 (5) [DOI] [Details]
	(2016)	'Blood biomarker discovery in drug-free schizophrenia: the contributionof proteomics and multiplex immunoassays' Sabherwal S;English JA;Föcking M;Cagney G;Cotter DR; (2016) 'Blood biomarker discovery in drug-free schizophrenia: the contributionof proteomics and multiplex immunoassays'. Expert Review Of Proteomics, 13 (12) [DOI] [Details]
	(2015)	'Proteomic and genomic evidence implicates the postsynaptic density in schizophrenia' Föcking M;Lopez LM;English JA;Dicker P;Wolff A;Brindley E;Wynne K;Cagney G;Cotter DR; (2015) 'Proteomic and genomic evidence implicates the postsynaptic density in schizophrenia'. Molecular Psychiatry, 20 (4) [DOI] [Details]
	(2015)	'Increased abundance of translation machinery in stem cell-derived neural progenitor cells from four schizophrenia patients' Topol A;English JA;Flaherty E;Rajarajan P;Hartley BJ;Gupta S;Desland F;Zhu S;Goff T;Friedman L;Rapoport J;Felsenfeld D;Cagney G;Mackay-Sim A;Savas JN;Aronow B;Fang G;Zhang B;Cotter D;Brennand KJ; (2015) 'Increased abundance of translation machinery in stem cell-derived neural progenitor cells from four schizophrenia patients'. Translational Psychiatry, 5 [DOI] [Details]
	(2015)	'Maternal immune activation induces changes in myelin and metabolic proteins, some of which can be prevented with risperidone in adolescence' Farrelly L;Föcking M;Piontkewitz Y;Dicker P;English J;Wynne K;Cannon M;Cagney G;Cotter DR; (2015) 'Maternal immune activation induces changes in myelin and metabolic proteins, some of which can be prevented with risperidone in adolescence'. Developmental Neuroscience, 37 (1) [DOI] [Details]
	(2015)	'Reduced protein synthesis in schizophrenia patient-derived olfactory cells' English JA;Fan Y;Föcking M;Lopez LM;Hryniewiecka M;Wynne K;Dicker P;Matigian N;Cagney G;Mackay-Sim A;Cotter DR; (2015) 'Reduced protein synthesis in schizophrenia patient-derived olfactory cells'. Translational Psychiatry, 5 [DOI] [Details]
	(2014)	'Targeted proteomics for validation of biomarkers in early psychosis' English JA;Wynne K;Cagney G;Cotter DR; (2014) 'Targeted proteomics for validation of biomarkers in early psychosis'. Biological Psychiatry, 76 (6) [DOI] [Details]
	(2014)	'Adolescent Risperidone treatment alters protein expression associated with protein trafficking and cellular metabolism in the adult rat prefrontal cortex' Farrelly LA;Dicker P;Wynne K;English J;Cagney G;Föcking M;Cotter DR; (2014) 'Adolescent Risperidone treatment alters protein expression associated with protein trafficking and cellular metabolism in the adult rat prefrontal cortex'. Journal of Proteomics, 14 (12) [DOI] [Details]
	(2013)	'Omega-3 fatty acid deficiency disrupts endocytosis, neuritogenesis, and mitochondrial protein pathways in the mouse hippocampus' English JA;Harauma A;Föcking M;Wynne K;Scaife C;Cagney G;Moriguchi T;Cotter DR; (2013) 'Omega-3 fatty acid deficiency disrupts endocytosis, neuritogenesis, and mitochondrial protein pathways in the mouse hippocampus'. Frontiers In Genetics, 4 [DOI] [Details]
	(2012)	'Partitioning the proteome: phase separation for targeted analysis of membrane proteins in human post-mortem brain' English JA;Manadas B;Scaife C;Cotter DR;Dunn MJ; (2012) 'Partitioning the proteome: phase separation for targeted analysis of membrane proteins in human post-mortem brain'. Plos One, 7 (6) [DOI] [Details]
	(2011)	'The neuroproteomics of schizophrenia' English JA;Pennington K;Dunn MJ;Cotter DR; (2011) 'The neuroproteomics of schizophrenia'. Biological Psychiatry, 69 (2) [DOI] [Details]
	(2011)	'Common proteomic changes in the hippocampus in schizophrenia and bipolar disorder and particular evidence for involvement of cornu ammonis regions 2 and 3' Föcking M;Dicker P;English JA;Schubert KO;Dunn MJ;Cotter DR; (2011) 'Common proteomic changes in the hippocampus in schizophrenia and bipolar disorder and particular evidence for involvement of cornu ammonis regions 2 and 3'. Archives of General Psychiatry, 68 (5) [DOI] [Details]
	(2010)	'Image analysis tools and emerging algorithms for expression proteomics' Dowsey AW;English JA;Lisacek F;Morris JS;Yang GZ;Dunn MJ; (2010) 'Image analysis tools and emerging algorithms for expression proteomics'. Journal of Proteomics, 10 (23) [DOI] [Details]
	(2010)	'Peptide fractionation in proteomics approaches' Manadas B;Mendes VM;English J;Dunn MJ; (2010) 'Peptide fractionation in proteomics approaches'. Expert Review Of Proteomics, 7 (5) [DOI] [Details]
	(2009)	'Assessing the use of thermal treatment to preserve the intact proteomes of post-mortem heart and brain tissue' Robinson AA;Westbrook JA;English JA;Borén M;Dunn MJ; (2009) 'Assessing the use of thermal treatment to preserve the intact proteomes of post-mortem heart and brain tissue'. Journal of Proteomics, 9 (19) [DOI] [Details]
	(2009)	'Comparative analysis of OFFGel, strong cation exchange with pH gradient, and RP at high pH for first-dimensional separation of peptides from a membrane-enriched protein fraction' Manadas B;English JA;Wynne KJ;Cotter DR;Dunn MJ; (2009) 'Comparative analysis of OFFGel, strong cation exchange with pH gradient, and RP at high pH for first-dimensional separation of peptides from a membrane-enriched protein fraction'. Journal of Proteomics, 9 (22) [DOI] [Details]
	(2009)	'2-D DIGE analysis implicates cytoskeletal abnormalities in psychiatric disease' English JA;Dicker P;Föcking M;Dunn MJ;Cotter DR; (2009) '2-D DIGE analysis implicates cytoskeletal abnormalities in psychiatric disease'. Journal of Proteomics, 9 (12) [DOI] [Details]
	(2008)	'Prominent synaptic and metabolic abnormalities revealed by proteomic analysis of the dorsolateral prefrontal cortex in schizophrenia and bipolar disorder' Pennington K;Beasley CL;Dicker P;Fagan A;English J;Pariante CM;Wait R;Dunn MJ;Cotter DR; (2008) 'Prominent synaptic and metabolic abnormalities revealed by proteomic analysis of the dorsolateral prefrontal cortex in schizophrenia and bipolar disorder'. Molecular Psychiatry, 13 (12) [DOI] [Details]
	(2006)	'Examination of 2-DE in the Human Proteome Organisation Brain Proteome Project pilot studies with the new RAIN gel matching technique' Dowsey AW;English J;Pennington K;Cotter D;Stuehler K;Marcus K;Meyer HE;Dunn MJ;Yang GZ; (2006) 'Examination of 2-DE in the Human Proteome Organisation Brain Proteome Project pilot studies with the new RAIN gel matching technique'. Journal of Proteomics, 6 (18) [DOI] [Details]

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Conference Publications

	Year	Publication
	(2009)	5th BSPR-EBI meeting, proteomics: from Technology to New Biology 8-10 July 2008, Wellcome Trust Conference Centre, Hinxton, Cambridge, UK English JA;Polden J;Robinson AA; (2009) Report 5th BSPR-EBI meeting, proteomics: from Technology to New Biology 8-10 July 2008, Wellcome Trust Conference Centre, Hinxton, Cambridge, UK [DOI] [Details]
	(2008)	1st Irish proteomics workshop April 17th 2008, University College Dublin, Conway Institute, Dublin, Ireland McManus CA;English JA; (2008) Report 1st Irish proteomics workshop April 17th 2008, University College Dublin, Conway Institute, Dublin, Ireland [DOI] [Details]