She subsequently moved to University College Cork to take up a senior postdoctoral position in APC Microbiome Ireland (APC), successfully obtaining a postdoctoral research fellowship from the Health Research Board, Ireland for this work. In 2008 she competitively obtained a tenured position at UCC as a Lecturer in Pathology. She teaches students across many programmes including undergraduate medicine and dentistry, graduate entry medicine, BSc in Biomedical Science, BSc in Medical and Health Sciences and the MSc in Cell and Molecular Biology. She has been Year 1 co-ordinator for University College Cork’s flagship Graduate Entry to Medicine programme since 2018.
Research in Beth’s laboratory focuses on innate immune responses, with a particular emphasis on the regulation and function of innate immunity in the gastrointestinal tract in both health and disease. Of particular relevance to her group are inflammatory receptor families (Toll-Like Receptors; IL-1 family; Death receptors) that contribute to intestinal diseases such as inflammatory bowel diseases and colorectal cancer. This work fits with her roles within both APC Microbiome Ireland and Cancer Research@UCC.
To date she has supervised 20 PhD/MD/MSc by research/MSc minor thesis/postdoctoral researchers to completion and has also supervised numerous summer, visiting and undergraduate students. She has a number of collaborations with academic and clinical partners, has published over 30 peer-reviewed articles, most as senior author, in high impact journals with her work cited >6400 times. She has secured funding for her research from multiple funding sources including charities (Breakthrough Cancer Research) and national funding bodies (Health Research Board/Science Foundation Ireland/Irish Research Council).
The inter-connected aims of Dr. Brint’s research programme are
1. The investigate novel functions, mechanism of action and regulation of innate immune proteins in intestinal health and disease.
2. The understand the role of the IL-1 family members (IL-33, IL-36, IL-37, IL-38) in cancer, particularly colorectal and lung cancer.
3. To develop novel therapeutic strategies for colorectal and lung cancer targeting IL-1 and TLR superfamily members.
4. To understand the interplay between inflammation and cell death in the context of intestinal health and disease
5. To understand the interactions between the microbiota and the innate immune system in intestinal disease and cancer.
GM1001: Fundamentals of Medicine I (2008 -
GM1002: Fundamentals of Medicine II (2008 -
GM1003: Fundamentals of Medicine III (2008 - Module Co-coordinator 2018- present
GM2001: (Fundamentals of Medicine IV (2008 - Module Co-ordinator 2012-2018
FM2004/PM2004: Foundations of Medicine: Mechanisms of Disease (2008 -
BM4007/PM3017: Cellular Pathology II (2009 -
BM4013: Biomedical Science Research Project (2009 -
MH1050: Introduction to Translational Medicine (2019 -
ML6001: Molecular Cell Biology Research Dissertation (2018 –
ML6002: Biological and Clinical Perspectives of Disease (2018-
MX5091- Medical Research Project and Elective Practise ( 2010-
Biography
Beth Brint is a Senior Lecturer in the Pathology Department, UCC, Funded Investigator in APC Microbiome Ireland, Faculty member of CancerResearch@UCC, currently a Health Research Board funded investigator and previously a Science Foundation Ireland funded Investigator. Beth completed her BSc (Hons) in Biochemistry at the University of Sussex, England. She subsequently undertook a PhD in the Biochemistry Department, Trinity College Dublin investigating molecular mechanism regulating the inflammatory/immune response. She developed her expertise in regulation of immune signalling by performing postdoctoral studies jointly between Trinity College Dublin and Xoma Ltd, a San Francisco based pharmaceutical company.She subsequently moved to University College Cork to take up a senior postdoctoral position in APC Microbiome Ireland (APC), successfully obtaining a postdoctoral research fellowship from the Health Research Board, Ireland for this work. In 2008 she competitively obtained a tenured position at UCC as a Lecturer in Pathology. She teaches students across many programmes including undergraduate medicine and dentistry, graduate entry medicine, BSc in Biomedical Science, BSc in Medical and Health Sciences and the MSc in Cell and Molecular Biology. She has been Year 1 co-ordinator for University College Cork’s flagship Graduate Entry to Medicine programme since 2018.
Research in Beth’s laboratory focuses on innate immune responses, with a particular emphasis on the regulation and function of innate immunity in the gastrointestinal tract in both health and disease. Of particular relevance to her group are inflammatory receptor families (Toll-Like Receptors; IL-1 family; Death receptors) that contribute to intestinal diseases such as inflammatory bowel diseases and colorectal cancer. This work fits with her roles within both APC Microbiome Ireland and Cancer Research@UCC.
To date she has supervised 20 PhD/MD/MSc by research/MSc minor thesis/postdoctoral researchers to completion and has also supervised numerous summer, visiting and undergraduate students. She has a number of collaborations with academic and clinical partners, has published over 30 peer-reviewed articles, most as senior author, in high impact journals with her work cited >6400 times. She has secured funding for her research from multiple funding sources including charities (Breakthrough Cancer Research) and national funding bodies (Health Research Board/Science Foundation Ireland/Irish Research Council).
Research Interests
The primary focus of my lab is the study of innate immunity and inflammation in health and disease. We are especially interested in understanding the complex functions and regulation of innate immune responses, as disruption of these mechanisms may lead to the development of disease. We have a particular emphasis on the role of innate immunity at mucosal barrier surfaces, in particular the gastrointestinal tract, where dysregulated immune responses lead to the development of Irritable Bowel Syndrome, Inflammatory Bowel Diseases (IBDs) and colon cancer. Of particular relevance to my group are inflammatory receptor families (Toll-Like Receptors (TLR); Interleukin (IL)-1 family Receptors) and understanding how these contribute to intestinal diseases.The inter-connected aims of Dr. Brint’s research programme are
1. The investigate novel functions, mechanism of action and regulation of innate immune proteins in intestinal health and disease.
2. The understand the role of the IL-1 family members (IL-33, IL-36, IL-37, IL-38) in cancer, particularly colorectal and lung cancer.
3. To develop novel therapeutic strategies for colorectal and lung cancer targeting IL-1 and TLR superfamily members.
4. To understand the interplay between inflammation and cell death in the context of intestinal health and disease
5. To understand the interactions between the microbiota and the innate immune system in intestinal disease and cancer.
Research Grants
| Project | Funding Body | Start Date | End Date | Award | |
|---|---|---|---|---|---|
| Developing the IL-36 receptor antagonist as a therapy for colon cancer | Health Research Board | 01-OCT-22 | 30-SEP-24 | €239,565.00 | |
| APC Microbiome Ireland Engaged Research Bursary | 01-JAN-22 | 29-DEC-22 | €3,000.00 | ||
| Catching Stories- Oral testimony of Infectious Disease in Ireland | Science Foundation Ireland | 01-JAN-22 | 01-MAR-23 | €48,500.00 | |
| Combining Electrochemotherapy with a Toll Like receptor agonist for the treatment of lung cancer | Breakthrough Cancer Research | 01-JAN-19 | 31-DEC-22 | €158,000.00 | |
| HEACOVID19 | 01-APR-21 | 31-JAN-22 | €7,764.00 | ||
| Developing the IL-1 Family Member IL-36 as a Novel Therapeutic Target for the Treatment of Colon Cancer | Irish Research Council | 01-OCT-18 | 31-JAN-22 | €74,625.00 | |
| To determine the biological consequences of IL-36 signalling in lung cancer. | UCC TRAP (Translational Research Access Programme) | 01-MAR-20 | 01-MAR-21 | €10,000.00 | |
| To Investigate whether IL-36 expression acts as a biomarker in Lung Cancer | UCC TRAP (Translational Research Access Programme) | 01-JAN-18 | 01-FEB-19 | €10,000.00 | |
| SFI "16/CW/3946" Dr E Brint - Inaugural joint annual meeting of the Irish Society of Immunology and the Microbiolobical Society - Irish Division - Exploring the microbe immune system interface. | Science Foundation of Ireland | 01-JUL-16 | 31-DEC-16 | €8,510.00 | |
| To Determine whether Expression of the IL-36 Cytokines or its Receptor Represent Potential Biomarkers for Colon Cancer Progression | Foreign Research Institute | 06-JUN-16 | 06-AUG-16 | €2,523.00 | |
| Characterisation of Toll-Like Receptor 10 as a key mediator of Inflammation In Crohns Disease. | Science Foundation Ireland | 01-OCT-14 | 31-AUG-16 | €75,000.00 | |
| The IL-33/ST2 axis and its potential involvement in human tumorigenesis | UCC TRAP (Translational Research Access Programme) | 01-OCT-14 | 30-SEP-15 | €9,000.00 | |
| The role of IL-33/ST2 in the progression of colon cancer | Health Research Board | 01-OCT-12 | 31-AUG-16 | €135,000.00 | |
| Molecular mechanisms regulating Toll-Like receptor signalling in Intestinal Epithelial Cells | Science Foundation of Ireland | 01-OCT-10 | 30-SEP-14 | €191,750.00 | |
| SFI - CSET 07/CE/B1368 Core2A BB & RC | Science Foundation of Ireland | 01-NOV-08 | 31-OCT-13 | €355,947.00 | |
| To examine the role of commensal bacteria in regulation of innate immune signalling at the intestinal barrier | Health Research Board | 01-OCT-08 | 31-DEC-08 | €198,000.00 |
Publications
Peer Reviewed Journals
| Year | Publication | |
|---|---|---|
| (2023) | 'IL-36 expression is increased in NSCLC with IL-36 stimulation of lung cancer cells promoting a pro-tumorigenic phenotype' Baker KJ;Buskiewicz E;Finucane M;Chelliah A;Burke L;Houston A;Brint E; (2023) 'IL-36 expression is increased in NSCLC with IL-36 stimulation of lung cancer cells promoting a pro-tumorigenic phenotype'. Cytokine, 165 [DOI] [Details] | |
| (2022) | 'Transcriptomic and functional analyses reveal a tumour-promoting role for the IL-36 receptor in colon cancer and crosstalk between IL-36 signalling and the IL-17/ IL-23 axis' Baker, KJ;Brint, E;Houston, A (2022) 'Transcriptomic and functional analyses reveal a tumour-promoting role for the IL-36 receptor in colon cancer and crosstalk between IL-36 signalling and the IL-17/ IL-23 axis'. British Journal of Cancer, [DOI] [Details] | |
| (2022) | 'DNA sensor associated type I Interferon signalling is increased in ulcerative colitis and induces JAK-dependent inflammatory cell death in colonic organoids' Flood, Peter; Fanning, Aine; Woznicki, Jerzy A.; Crowley, Tadhg; Christopher, Andrea; Vaccaro, Alessandra; Houston, Aileen; McSweeney, Sheila; Ross, Sarah; Hogan, Aileen; Brint, Aileen; Skowyra, Agnieszka; Bustamante, Milan; Ambrose, Monica; Moloney, Gerard M.; MacSharry, John; Hammarström, Marie-Louise; Hurley, Margot; Fitzgibbons, Christine; Quigley, Eamonn M. M.; Shanahan, Fergus; Zulquernain, Syed A.; McCarthy, Jane; Dodson, G. Steven; Dabbagh, Karim; McRae, Bradford L.; Melgar, Silvia; Nally, Ken (2022) 'DNA sensor associated type I Interferon signalling is increased in ulcerative colitis and induces JAK-dependent inflammatory cell death in colonic organoids'. American Journal of Physiology - Gastrointestinal and Liver Physiology, [DOI] [Full Text] [Details] | |
| (2022) | 'Defining optimal parameters to maximize the effect of electrochemotherapy on lung cancer cells whilst preserving the integrity of immune cells' Bendix MB;Houston A;Forde PF;Brint E; (2022) 'Defining optimal parameters to maximize the effect of electrochemotherapy on lung cancer cells whilst preserving the integrity of immune cells'. Bioelectrochemistry, 148 [DOI] [Details] | |
| (2022) | 'Electrochemotherapy and immune interactions; A boost to the system?' Bendix MB;Houston A;Forde PF;Brint E; (2022) 'Electrochemotherapy and immune interactions; A boost to the system?'. Ejso, 48 (9) [DOI] [Details] | |
| (2022) | 'IL-36 signalling enhances a pro-tumorigenic phenotype in colon cancer cells with cancer cell growth restricted by administration of the IL-36R antagonist' Baker K;O'Donnell C;Bendix M;Keogh S;Byrne J;O'Riordain M;Neary P;Houston A;Brint E; (2022) 'IL-36 signalling enhances a pro-tumorigenic phenotype in colon cancer cells with cancer cell growth restricted by administration of the IL-36R antagonist'. Oncogene, 41 (19) [DOI] [Full Text] [Details] | |
| (2021) | 'IL-36 cytokines in inflammatory and malignant diseases: not the new kid on the block anymore' Byrne J;Baker K;Houston A;Brint E; (2021) 'IL-36 cytokines in inflammatory and malignant diseases: not the new kid on the block anymore'. Cellular and Molecular Life Sciences, 78 (17-18) [DOI] [Details] | |
| (2021) | 'Electroporation of suspension cell lines - A proposed assay set for optimizations' Bendix, MB;Brint, E;Forde, PF (2021) 'Electroporation of suspension cell lines - A proposed assay set for optimizations'. Bioelectrochemistry, 142 [DOI] [Details] | |
| (2020) | 'Teaching physiology to medical students in the COVID-19 era with synchronous formative assessments utilising simultaneous, combined Zoom and Socrative platforms' M Abdulla; E Brint; M. Rae (2020) 'Teaching physiology to medical students in the COVID-19 era with synchronous formative assessments utilising simultaneous, combined Zoom and Socrative platforms'. Journal of Education, 2 (1):12-32 [DOI] [Details] | |
| (2019) | 'Editorial: IL-1 Family Members in Health and Disease' Brint, E;Kamradt, T;Doyle, SL (2019) 'Editorial: IL-1 Family Members in Health and Disease'. [DOI] [Details] | |
| (2019) | 'IL-1 Family Members in Cancer; Two Sides to Every Story' Baker, KJ;Houston, A;Brint, E (2019) 'IL-1 Family Members in Cancer; Two Sides to Every Story'. Frontiers In Immunology, 10 [DOI] [Full Text] [Details] | |
| (2018) | 'Engagement of Fas differentially regulates the production of LPS-induced pro-inflammatory cytokines and type I Interferons' Brennan K, Lyons C, Fernandes P, Doyle S, Houston A, Brint E (2018) 'Engagement of Fas differentially regulates the production of LPS-induced pro-inflammatory cytokines and type I Interferons'. Febs Journal, [DOI] [Details] | |
| (2016) | 'IL-36 alpha expression is elevated in ulcerative colitis and promotes colonic inflammation' Russell, SE,Horan, RM,Stefanska, AM,Carey, A,Leon, G,Aguilera, M,Statovci, D,Moran, T,Fallon, PG,Shanahan, F,Brint, EK,Melgar, S,Hussey, S,Walsh, PT (2016) 'IL-36 alpha expression is elevated in ulcerative colitis and promotes colonic inflammation'. Mucosal immunology, 9 :1193-1204 [DOI] [Details] | |
| (2016) | 'An antitumorigenic role for the IL-33 receptor, ST2L, in colon cancer' O'Donnell, C;Mahmoud, A;Keane, J;Murphy, C;White, D;Carey, S;O'Riordain, M;Bennett, MW;Brint, E;Houston, A (2016) 'An antitumorigenic role for the IL-33 receptor, ST2L, in colon cancer'. British Journal of Cancer, 114 :37-43 [DOI] [Full Text] [Details] | |
| (2016) | 'Differential expression of key regulators of Toll-like receptors in ulcerative colitis and Crohn's disease: a role for Tollip and peroxisome proliferator-activated receptor gamma?' Fernandes, P;MacSharry, J;Darby, T;Fanning, A;Shanahan, F;Houston, A;Brint, E (2016) 'Differential expression of key regulators of Toll-like receptors in ulcerative colitis and Crohn's disease: a role for Tollip and peroxisome proliferator-activated receptor gamma?'. Clinical and Experimental Immunology, 183 :358-368 [DOI] [Details] | |
| (2015) | 'An anti-tumorigenic role for ST2L in colon cancer' O’Donnell C, Mahmoud A, Keane J, Murphy C, Carey S, O’Riordain M, Bennett MW, Brint E and Houston A (2015) 'An anti-tumorigenic role for ST2L in colon cancer'. British Journal of Cancer, [Details] | |
| (2015) | 'Engagement of Fas on Macrophages Modulates Poly I:C Induced Cytokine Production with Specific Enhancement of IP-10' Lyons, C;Fernandes, P;Fanning, LJ;Houston, A;Brint, E (2015) 'Engagement of Fas on Macrophages Modulates Poly I:C Induced Cytokine Production with Specific Enhancement of IP-10'. Plos One, 10 [DOI] [Full Text] [Details] | |
| (2014) | 'Tracing innate immune defences along the path of Listeria monocytogenes infection' Regan T, Macsharry J, Brint E (2014) 'Tracing innate immune defences along the path of Listeria monocytogenes infection'. Immunology And Cell Biology, [DOI] [Details] | |
| (2014) | 'Microbiota-host interactions in irritable bowel syndrome: epithelial barrier, immune regulation and brain-gut interactions' Hyland NP, Quigley EM, Brint E (2014) 'Microbiota-host interactions in irritable bowel syndrome: epithelial barrier, immune regulation and brain-gut interactions'. World journal of gastroenterology : WJG, 20 (27):8859-8866 [DOI] [Details] | |
| (2014) | 'Intestinal Expression of Fas and Fas Ligand Is Upregulated by Bacterial Signaling through TLR4 and TLR5, with Activation of Fas Modulating Intestinal TLR-Mediated Inflammation' Fernandes, P;O'Donnell, C;Lyons, C;Keane, J;Regan, T;O'Brien, S;Fallon, P;Brint, E;Houston, A (2014) 'Intestinal Expression of Fas and Fas Ligand Is Upregulated by Bacterial Signaling through TLR4 and TLR5, with Activation of Fas Modulating Intestinal TLR-Mediated Inflammation'. Journal of immunology (Baltimore, Md. : 1950), 193 :6103-6113 [DOI] [Details] | |
| (2013) | 'Identification of TLR10 as a key mediator of the inflammatory response to Listeria monocytogenes in intestinal epithelial cells and macrophages' Regan, T.,Nally, K.,Carmody, R.,Houston, A.,Shanahan, F.,Macsharry, J.,Brint, E. (2013) 'Identification of TLR10 as a key mediator of the inflammatory response to Listeria monocytogenes in intestinal epithelial cells and macrophages'. Journal of Immunology, 191 (1212):6084-92 [Details] | |
| (2013) | 'Life in the Fas lane: Differential Outcomes of Fas Signalling' Brint E, O'Callaghan G and Houston A (2013) 'Life in the Fas lane: Differential Outcomes of Fas Signalling'. Cellular and molecular life sciences : CMLS, [Full Text] [Details] | |
| (2013) | 'Bcl-deficiency protects against dextran-sodium sulphate-induced colitis in the mouse' O'Carroll, C.,Moloney, G.,Hurley, G.,Melgar, S.,Brint, E.,Nally, K.,Nibbs, R. J.,Shanahan, F.,Carmody, R. J. (2013) 'Bcl-deficiency protects against dextran-sodium sulphate-induced colitis in the mouse'. Clin Exp Immunol, 173 (22):332-342332 [Details] | |
| (2011) | 'Differential expression of toll-like receptors in patients with irritable bowel syndrome' Brint EK, MacSharry J, Fanning A, Shanahan F, Quigley EM (2011) 'Differential expression of toll-like receptors in patients with irritable bowel syndrome'. The American Journal of Gastroenterology, 106 (2):329-336 [DOI] [Details] | |
| (2009) | 'Control of Toll-Like Receptor (TLR) Signalling in Inflammatory Bowel Disease (IBD): Differential Expression of Key Regulators of TLRS in Ulcerative Colitis (UC) and Crohn's Disease (CD)' Brint, E.,Quigley, E. M.,Shanahan, F. (2009) 'Control of Toll-Like Receptor (TLR) Signalling in Inflammatory Bowel Disease (IBD): Differential Expression of Key Regulators of TLRS in Ulcerative Colitis (UC) and Crohn's Disease (CD)'. Gastroenterology, 136 (55) [Details] | |
| (2009) | 'Toll-Like Receptor mRNA Expression Is Selectively Increased in the Colonic Mucosa of Two Animal Models Relevant to Irritable Bowel Syndrome' McKernan, DP,Nolan, A,Brint, EK,O'Mahony, SM,Hyland, NP,Cryan, JF,Dinan, TG; (2009) 'Toll-Like Receptor mRNA Expression Is Selectively Increased in the Colonic Mucosa of Two Animal Models Relevant to Irritable Bowel Syndrome'. Plos One, 4 [DOI] [Details] | |
| (2006) | 'Trif-related adapter molecule is phosphorylated by PKC{epsilon} during Toll-like receptor 4 signaling' McGettrick AF, Brint EK, Palsson-McDermott EM, Rowe DC, Golenbock DT, Gay NJ, Fitzgerald KA, O'Neill LA (2006) 'Trif-related adapter molecule is phosphorylated by PKC{epsilon} during Toll-like receptor 4 signaling'. Proceedings of The National Academy of Sciences of The United States of America, 103 (24):9196-9201 [DOI] [Details] | |
| (2005) | 'Negative regulation of toll-like receptor-mediated immune responses' Liew FY, Xu D, Brint EK, O'Neill LA (2005) 'Negative regulation of toll-like receptor-mediated immune responses'. Nature reviews. Immunology, 5 (6):446-458 [DOI] [Details] | |
| (2004) | 'Crystal structure of the Toll/interleukin-1 receptor domain of human IL-1RAPL' Khan JA, Brint EK, O'Neill LA, Tong L (2004) 'Crystal structure of the Toll/interleukin-1 receptor domain of human IL-1RAPL'. The Journal of Biological Chemistry, 279 (30):31664-31670 [DOI] [Details] | |
| (2004) | 'ST2 is an inhibitor of interleukin 1 receptor and Toll-like receptor 4 signaling and maintains endotoxin tolerance' Brint EK, Xu D, Liu H, Dunne A, McKenzie AN, O'Neill LA, Liew FY (2004) 'ST2 is an inhibitor of interleukin 1 receptor and Toll-like receptor 4 signaling and maintains endotoxin tolerance'. Nature immunology, 5 (4):373-379 [DOI] [Details] | |
| (2004) | 'Mal interacts with tumor necrosis factor receptor-associated factor (TRAF)-6 to mediate NF-kappaB activation by toll-like receptor (TLR)-2 and TLR4' Mansell A, Brint E, Gould JA, O'Neill LA, Hertzog PJ (2004) 'Mal interacts with tumor necrosis factor receptor-associated factor (TRAF)-6 to mediate NF-kappaB activation by toll-like receptor (TLR)-2 and TLR4'. The Journal of Biological Chemistry, 279 (36):37227-37230 [DOI] [Details] | |
| (2003) | 'Bruton's tyrosine kinase is a Toll/interleukin-1 receptor domain-binding protein that participates in nuclear factor kappaB activation by Toll-like receptor 4' Jefferies CA, Doyle S, Brunner C, Dunne A, Brint E, Wietek C, Walch E, Wirth T, O'Neill LA (2003) 'Bruton's tyrosine kinase is a Toll/interleukin-1 receptor domain-binding protein that participates in nuclear factor kappaB activation by Toll-like receptor 4'. The Journal of Biological Chemistry, 278 (28):26258-26264 [DOI] [Details] | |
| (2002) | 'Characterization of signaling pathways activated by the interleukin 1 (IL-1) receptor homologue T1/ST2. A role for Jun N-terminal kinase in IL-4 induction' Brint EK, Fitzgerald KA, Smith P, Coyle AJ, Gutierrez-Ramos JC, Fallon PG, O'Neill LA (2002) 'Characterization of signaling pathways activated by the interleukin 1 (IL-1) receptor homologue T1/ST2. A role for Jun N-terminal kinase in IL-4 induction'. The Journal of Biological Chemistry, 277 (51):49205-49211 [DOI] [Details] | |
| (2001) | 'Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction' Fitzgerald KA, Palsson-McDermott EM, Bowie AG, Jefferies CA, Mansell AS, Brady G, Brint E, Dunne A, Gray P, Harte MT, McMurray D, Smith DE, Sims JE, Bird TA, O'Neill LA (2001) 'Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction'. Nature, 413 (6851):78-83 [DOI] [Details] |
Edited Books
| Year | Publication | |
|---|---|---|
| (2019) | IL-1 family members in Health and disease E Brint, S. Doyle, T Kamradt (Ed.). (2019) IL-1 family members in Health and disease EU: Frontiers in Immunology. [DOI] [Details] | |
| (2005) | Toll-like Receptors in Inflammation E Brint, LAJ O'Neill (Ed.). (2005) Toll-like Receptors in Inflammation Switzerland: Birkhauser. [Details] |
Book Chapters
| Year | Publication | |
|---|---|---|
| (2019) | 'IL-1 family members in cancer; two sides to every story' K Baker; E Brint (2019) 'IL-1 family members in cancer; two sides to every story' In: Il-1 Family Members in Health and Disease. EU: Frontiers in Immunology. [Details] | |
| (2015) | 'Toll-Like Receptors' P Fernandes, E Brint (2015) 'Toll-Like Receptors' In: Encyclopaedia of Inflammatory Diseases. Switzerland: Birkhauser. [Details] | |
| (2005) | 'Endogenous regulation of Toll-Like Receptors' EK Brint (2005) 'Endogenous regulation of Toll-Like Receptors' In: Toll-Like Receptors in Inflammation. Switzerland: Birkhauser. [Details] |
Professional Activities
Honours and Awards
| Year | Title | Awarding Body | |
|---|---|---|---|
| 2021 | APC Microbiome Ireland Education and Public Engagement Champion | University College Cork | |
| 2021 | Aurora, Women in Leadership in Higher Education | Advance HE | |
| 2020 | Nominated for UCC Excellence in Teaching Award | University College Cork | |
| 2008 | Health Research Board Ireland – Postdoctoral Career Development Fellowship Award | Health Research Board | |
| 2008 | Poster of Distinction- Digestive Disease Week | American Gastroenterology Association | |
| 2003 | Outstanding Scholor award | Biochemical Society | |
| 2001 | Sheldon Woolfe Prize | International Cytokine Society |
Professional Associations
| Association | Function | From / To | |
|---|---|---|---|
| Irish Association for Cancer Researchers 2018- Present | Commitee member | / | |
| Irish Society for Immunology 2005- Present | Committee member | 01-JAN-05 / | |
| CancerResearch@UCC | Faculty Member | 01-JUN-21 / | |
| APC MIcrobiome Ireland | Member | 14-JUN-06 / | |
| International Cytokine Society 2018-Present | Member | / | |
| Biochemical Society 2005-2018 | Member | / | |
| American Gastroenterological Association (AGA) 2010-2016 | Member | / |
Conference Contributions
| Year | Publication | |
|---|---|---|
| (2022) | Irish Asscoiation of Cancer Research, K Baker; A Houston; E Brint (2022) IL-36 signalling enhances a pro-tumorigenic phenotype in colon cancer cells with cancer cell growth restricted by administration of the IL-36R antagonist. [Poster Presentation], Irish Asscoiation of Cancer Research, Cork, Ireland . [Details] | |
| (2022) | The International Society for Electroporation based Technologies and Treatments, M Bendix, A. Houston, P. Forde, E Brint (2022) Impact of electrochemotherapy on immune cells in the context of cancer – In vitro study. [Invited Lectures (Conference)], The International Society for Electroporation based Technologies and Treatments, Copenhagen, Denmark . [Details] | |
| (2022) | American association of Cancer Research 2022, K Baker; A Houston, E Brint (2022) IL-36 signalling enhances a pro-tumorigenic phenotype in colon cancer cells with cancer cell growth restricted by administration of the IL-36R antagonist. [Oral Presentation], American association of Cancer Research 2022, New Orleans US . [Details] | |
| (2019) | Cytokine 2019, E Brint (2019) Understanding the role of IL-36 in cancer. [Oral Presentation], Cytokine 2019, Vienna, Austria . [Details] | |
| (2019) | The International Society for Electroportaion based Technologies and Treatments, M Bendix, p. Forde, E Brint (2019) Effect of electroporation delivery on Lung cancer cells. [Invited Lectures (Conference)], The International Society for Electroportaion based Technologies and Treatments, Amsterdam, The Netherlands . [Details] | |
| (2017) | Keystone Symposium, E Brint (2017) Engagement of Fas differentially regulated the Production of LPS-Induced Pro-Inflammatory Cytokines and Type 1 Interferons. [Oral Presentation], Keystone Symposium, Dublin, ireland . [Details] | |
| (2015) | Irish Association for Cancer Research, O’Donnell C, Brint E and Houston A (2015) The Potential Role of the ST2/IL-33 axis in Colon Cancer. [Poster Presentation], Irish Association for Cancer Research, Limerick . [Details] | |
| (2015) | Cell Symposium on Cancer, Inflammation and Immunity, O’Donnell C, Mahmoud A, Bennett MW, Brint E and Houston A (2015) Characterisation of the Role of ST2 and its Ligand, IL-33, in Colon Cancer. [Poster Presentation], Cell Symposium on Cancer, Inflammation and Immunity, Sitges, Spain . [Details] | |
| (2015) | Keystone Symposia on Mechanisms of Pro-Inflammatory Diseases, O’Donnell C, Mahmoud A, Bennett MW, Houston A and Brint E (2015) An anti-tumorigenic role for the IL-33/ST2 axis in colon cancer. [Poster Presentation], Keystone Symposia on Mechanisms of Pro-Inflammatory Diseases, California, USA . [Details] | |
| (2014) | EMBO Symposium- Tumour Microenvironment and Signalling, O’Donnell C, Mahmoud A, Bennett MW, Brint E and Houston A (2014) Characterisation of the Role of ST2 and its Ligand, IL-33, in Colon Cancer. [Poster Presentation], EMBO Symposium- Tumour Microenvironment and Signalling, Heidelberg, Germany . [Details] | |
| (2014) | Innate Immunity Summit, Elizabeth Brint (2014) Invited Speaker. [Invited Lectures (Conference)], Innate Immunity Summit, London, UK . [Details] | |
| (2014) | Invited Speaker, Elizabeth Brint (2014) Invited Speaker. [Oral Presentation], Invited Speaker, Trinity College Dublin . [Details] | |
| (2014) | Irish Society of Immunology, O' Donnell C, Houston A and Brint E (2014) Characterisation of the Role of ST2/IL-33 in Colon Carcinogenesis. [Oral Presentation], Irish Society of Immunology, Galway . [Details] | |
| (2014) | Irish Association for Cancer Research, O’Donnell C, Mahmoud A, Bennett MW, Brint E and Houston A (2014) Investigation of the Role of ST2 and its ligand, IL-33, in Colon Cancer. [Poster Presentation], Irish Association for Cancer Research, Galway . [Details] | |
| (2014) | Irish Society of Immunology, Lyons C, Moran R, Fanning L, Houston A and Brint E (2014) Double-stranded RNA-induced inflammatory responses in macrophages are modified by Fas Signalling. [Poster Presentation], Irish Society of Immunology, Dublin . [Details] | |
| (2014) | Irish Association for Cancer Research Annual Meeting, Fernandes P, Lyons C, Brint E and Houston A (2014) Fas modulates intestinal TLR-mediated inflammation and suppression of Fas in colon cancer cells reduces tumour growth in vivo. [Oral Presentation], Irish Association for Cancer Research Annual Meeting, Galway . [Details] | |
| (2014) | EMBO Symposium - Cellular signalling and cancer therapy, Fernandes P, Lyons C, Brint E and Houston A (2014) Fas modulates intestinal TLR-mediated inflammation and suppression of Fas in colon cancer cells reduces tumour growth in vivo. [Poster Presentation], EMBO Symposium - Cellular signalling and cancer therapy, Croatia . [Details] | |
| (2013) | ICI 2013 – 15th International Congress of Immunology, Lyons C, Moran R, Houston A and Brint E (2013) Double-stranded RNA (dsRNA)-induced IP-10/CXCL-10 production is augmented by Fas activation. [Poster Presentation], ICI 2013 – 15th International Congress of Immunology, Milan, Italy . [Details] | |
| (2013) | Irish Society of Immunology, Lyons C, Moran R, Houston A and Brint E. (2013) Fas activation augments double-stranded RNA (dsRNA)-induced IP-10/CXCL-10 production. [Poster Presentation], Irish Society of Immunology, Dublin . [Details] | |
| (2013) | Irish Society of Immunology, O’Donnell C, Houston A and Brint E (2013) The Potential role of ST2 and its ligand IL-33 in colon carcinogenesis. [Poster Presentation], Irish Society of Immunology, Dublin . [Details] | |
| (2012) | Irish Society of Immunology, Lyons, C., Moran, R., Houston, A., Brint, E. (2012) Double stranded RNA (dsRNA) requires Fas (CD95) for optimal IP-10/CXCL10 production. [Poster Presentation], Irish Society of Immunology, Dublin , 20-SEP-12 - 21-SEP-12. [Details] | |
| (2012) | Keystone Symposium - Innate Immunity: Sensing the Microbes and Damage Signals, Fernandes, P; Houston, A; Brint, EK (2012) TLRs 4 and 5 upregulate Fas and FasL expression in intestinal epithelial cells resulting in increased cytokine production. [Poster Presentation], Keystone Symposium - Innate Immunity: Sensing the Microbes and Damage Signals, Colorado, USA , 04-MAR-12 - 09-MAR-12. [Details] | |
| (2012) | European Association for Cancer Research, Fernandes, P., Brint, E., Houston, A. (2012) Fas (CD95) signalling and inflammation in colon cancer. [Poster Presentation], European Association for Cancer Research, Dublin , 17-SEP-12 - 19-SEP-12. [Details] | |
| (2012) | Irish Society of Immunology, Fernandes, P., Brint, E., Houston, A. (2012) Fas (CD95) Signalling and Inflammation in Colon Cancer. [Oral Presentation], Irish Society of Immunology, Dublin , 20-SEP-12 - 21-SEP-12. [Details] | |
| (2010) | Digestive Diseases Week, 2010, Brint E., O'Callaghan GP., Regan T., Shanahan F., Houston A.; (2010) Synergy between Fas and TLR4 in promoting pro-inflammatory cytokine synthesis in macrophages and intestinal epithelial cells - relevance to IBD. [Poster Presentation], Digestive Diseases Week, 2010, New Orleans , 02-MAY-10 - 05-MAY-10. [Details] | |
| (2010) | Keystone Symposium: Innate Immunity: Mechanisms Linking with Adaptive Immunity, Houston, A., Regan, T., O'Callaghan, G., Shanahan, F., Brint, EK.; (2010) Interplay between Fas and TLR signalling- regulation of inflammation in the gastrointestinal tract ?. [Poster Presentation], Keystone Symposium: Innate Immunity: Mechanisms Linking with Adaptive Immunity, Dublin , 07-JUN-10 - 12-JUN-10. [Details] |
Committees
| Committee | Function | From / To | |
|---|---|---|---|
| School Of Medicine AthenaSwan Self Assessment Team | Member | 2022 / | |
| Irish Association of Cancer Research | Committee member | 2022 / | |
| School Of Medicine Undergraduate Curriculum Commitee | Member | 2019 / | |
| UCC AEEC | Member | 2019 / | |
| AthenaSwan University Working Group on Flexible Working | Member | 2019 / 2020 | |
| Medical Student Board | Faculty Member | 2019 / | |
| Biomedical Science BSc Board of studies 2008-Present | Member | 2008 / | |
| Departmental Graduate studies committee | Member | 2008 / | |
| Irish Society for Immunology | Secretary | 2013 / 2021 | |
| Graduate Entry to Medicine (GEM) Teaching and Oversight Committee | Member | 2008 / |
Employment
| Employer | Position | From / To | |
|---|---|---|---|
| Pathology Department, University College Cork | Lecturer | 09-OCT-08 / | |
| University College Cork | Postdoctoral Research Scientist | 01-JUN-06 / 01-SEP-08 | |
| Xoma Ltd. San Francisco, US | Postdoctoral Research Scientist | 01-APR-04 / 30-JUN-06 | |
| Trinity College Dublin | Postdoctoral Research Scientist | 01-JAN-04 / 28-JUL-05 |
Education
| Year | Institution | Qualification | Subject | |
|---|---|---|---|---|
| 2021 | University College Cork | Postgraduate Diploma in Teaching and Learning | Teaching and Learning | |
| 2020 | University College Cork | PostGraduate Certificate in Teaching and Learning | Teaching and Learning | |
| 2003 | Trinity College Dublin | PHD | Biochemisty | |
| 1999 | University of Sussex | BSC | Biochemistry |
Outreach Activities
| Description | |
|---|---|
Public talk 'Catching Stores' Science Week 2022 | |
Development of a workshop entitled 'Investigating Immunity' for Primary School children 2020-2023 | |
Interactive presentations for families at Cork Science Festival November 2022 'Catching Stores' | |
Primary School talks given annually 2006-2018 | |
Media activities (Radio, Print, television) for COVID19 awareness and understanding | |
BT Young Scientist judge 2016 |
Journal Activities
| Journal | Role | To / From | |
|---|---|---|---|
| Frontiers In Immunology | Member of Editorial Board | 01-NOV-21 - | |
| World Journal Of Gastroenterology | Editor | 01-JAN-16 - 01-JUL-17 | |
| Cellular Immunology | Referee | - | |
| Febs Journal | Referee | - | |
| Proceedings Of The National Academy Of Science | Referee | - | |
| Nature Reviews Gastroenterology & Hepatology | Referee | - | |
| Cytokine | Referee | - | |
| European Journal Of Immunology | Referee | - | |
| Biochemistry Biophys Research Communication | Referee | - | |
| Journal Of Immunology | Referee | - | |
| Cellular And Molecular Immunology | Referee | - | |
| Cellular And Molecular Life Sciences | Referee | - |
Other Activities
| Description | |
|---|---|
Joint Organiser. 'Catching Stories' Exhibition. Boole Library, UCC 2023 | |
Member of Local Organising Committee European Congress of Immunology 2024 | |
Session chair - European Congress of Immunology. Online 2021 | |
Speaker- Cytokine 2019. Vienna | |
Keystone Symposium 'Inflammation and Cell Death. Dublin 2017. Speaker | |
Keystone Symposium, Squaw Creek, US. 2015. Invited Speaker. | |
Lead Organiser of the inaugural joint meeting of Irish society for Immunology/Microbiological Society; Cork 2016 |
Teaching Activities
Teaching Interests
Year 1 Co-ordinator Graduate Entry to Medicine 2018-PresentGM1001: Fundamentals of Medicine I (2008 -
GM1002: Fundamentals of Medicine II (2008 -
GM1003: Fundamentals of Medicine III (2008 - Module Co-coordinator 2018- present
GM2001: (Fundamentals of Medicine IV (2008 - Module Co-ordinator 2012-2018
FM2004/PM2004: Foundations of Medicine: Mechanisms of Disease (2008 -
BM4007/PM3017: Cellular Pathology II (2009 -
BM4013: Biomedical Science Research Project (2009 -
MH1050: Introduction to Translational Medicine (2019 -
ML6001: Molecular Cell Biology Research Dissertation (2018 –
ML6002: Biological and Clinical Perspectives of Disease (2018-
MX5091- Medical Research Project and Elective Practise ( 2010-
Recent Postgraduates
| Graduation Year | Student Name | Institution | Degree Type | Thesis Title | |
|---|---|---|---|---|---|
| 2026 | Meabh Finucane - Current student | University College Cork | PHD | ||
| 2023 | Maura Bendix | University College Cork | PHD | ||
| 2023 | Kevin Baker | University College Cork | PHD | ||
| 2017 | Amr Mahmoud | University College Cork | MSc Biomedical Science | ||
| 2017 | Declan White | University College Cork | MSc Biomedical Science | ||
| 2016 | Philana Fernandes | University College Cork | PHD | ||
| 2016 | Catriona Lyons | University College Cork | PHD | ||
| 2016 | Charlotte O'Donnell | University College Cork | PHD | ||
| 2014 | Tim Regan | University College Cork | PHD | Novel mechanisms of innate immune regulation in the gastrointestinal tract |
Research Information
Internal Collaborators
| Name | Institute | Country | |
|---|---|---|---|
| John MacSharry | University College Cork | IRELAND | |
| Dr. Cliona O'Carroll | University College Cork | IRELAND | |
| Aileen Houston | University College Cork | IRELAND |
External Collaborators
| Name | Organisation / Institute | Country | |
|---|---|---|---|
| Prof. Paul Murray | Uniiversity of Limerick | IRELAND | |
| Prof. Thomas Kamradt | Berlin University | GERMANY | |
| Aideen Ryan | University of Galway | IRELAND | |
| Prof. Sarah Doyle | Trinity College Dublin | IRELAND | |
| Pat Walsh | National Childrens Research Centre | IRELAND |