Research Profile

David Kerins

Biography

David Kerins, received a BSc in Physiology in 1981, and an MB, BAO, BCh from University College Cork in 1984. He completed sequential fellowships in Clinical Pharmacology and in Clinical Cardiology at Vanderbilt University, Nashville TN. Following appointments as an Associate Professor of Medicine and Chief of the Cardiology Section at Nashville VA. He was appointed as Associate Professor of Therapeutics at University College Cork and Consultant Physician at Mercy University Hospital in 2006, and served as Dean of the Medical School, UCC from 2007-2010. He has research interests in anti-platelet and anti-thrombotic therapy, vascular biology with a particular focus on the renin-angiotensin and fibrinolytic pathways, and non-invasive cardiac imaging. Professor Kerins is a fellow of the American Heart Association, the American College of Cardiology, the European Society of Cardiology and the American Society of Echocardiography. He is a Consultant Cardiologist and is the Clinical Director at Mercy University Hospital.

Research Interests

                         

Platelet function, vascular biology, endothelial function, non-invasive cardiac imaging

My research has focussed on aspects of vascular biology. Initially my attention was on the process of platelet activation in the setting of coronary thrombolysis (fibrinolysis). This indicated that in a human study that we initiated that platelet activation did indeed occur when patients received therapeutics t-PA. These observations were followed by a series of studies in an experimental model of coronary thrombosis that demonstrated the mechanisms and extent of platelet activation and explored mechanisms to limit the deleterious effects of such platelet activation.

Further studies examined the interaction between the fibrinolytic pathway and the renin-angiotensin system. They included the inititial demonstration that the angiotensin IV receptor was biologically active in regulating the expression of plasminogen activator inhibitor 1 (PAI-1). The role of the fibrinolytic pathway in organ regeneration and in the process of atherosclerosis were also the subject of many studies. Most recently these interests are applied in a study of the effects of functional food products on a variety of parameters that influence thrombosis and coagulation as part of the NationalFunctional Food Research Center grant at UCC. My role in this project is a lead investigator in the section on cardiovascular disease (working party 6d).

In addition to an interest in the basic science of vascular biology I have also developed a more clinically active interest in non-invasive cardiac imaging. This has resulted in studies to address the role of echocardiography and of magnetic resonance imaging in vascular disease. This is currently expressed in a joint study with colleagues from the Department of Rheumatology at Cork University Hospital in the evaluation of preclinical atherosclerosis in a patient population with rheumatoid arthritis.

Publications

Book Chapters

 YearPublication
(2001)'Drugs used for the treatment of myocardial ischemia'
Kerins D.M., Robertson R.M., Robertson D.; (2001) 'Drugs used for the treatment of myocardial ischemia' In: The Pharmacological Basis of Therapeutics (10th Edition). unknown: unknown. [Details]
(1999)'Antithrombotic and anticoagulant agents in the secondary prevention of myocardial infarction'
Kerins D.M. and Ridker P.M. (1999) 'Antithrombotic and anticoagulant agents in the secondary prevention of myocardial infarction' In: Clinical Trials in Cardiovascular Disease: a Companion Volume to Braunwald’s Textbook of Cardiovascular Disease. United States: W.B. Saunders. [Details]
(1992)'Arachidonic acid metabolism, platelets and thromboembolic disease'
Kerins D.M., & FitzGerald G.A (1992) 'Arachidonic acid metabolism, platelets and thromboembolic disease' In: Handbook of Experimental Pharmacology - Volume 101: Biochemical Pharmacology of Blood and Blood-Forming Organs. New York: Springer-Verlag. [DOI] [Details]
(1992)'Aspirin: Pharmacokinetics and pharmacodynamic effects on platelets and vascular function'
Charman W.N., Kerins D.M., & FitzGerald G.A (1992) 'Aspirin: Pharmacokinetics and pharmacodynamic effects on platelets and vascular function' In: Aspirin and other salicylates. London: Chapman and Hall. [Details]
(1990)'Prostacyclin and prostaglandin E1: molecular mechanisms and clinical utility'
Kerins D.M., Murray, R., & FitzGerald, G.A. (1990) 'Prostacyclin and prostaglandin E1: molecular mechanisms and clinical utility' In: Progress in Hemostasis and Thrombosis. United States: Saunders. [Details]
(1989)'Functional relevance and mechanisms of platelet activation during coronary thrombolysis'
Fitzgerald D.J., Kerins D.M., & FitzGerald G.A. (1989) 'Functional relevance and mechanisms of platelet activation during coronary thrombolysis' In: Platelets and Vascular occlusion. Rome, Italy: Raven Press. [Details]

Other Journals

 YearPublication
(1998)'Glycoprotein IIb/IIIa inhibitors in acute coronary syndromes: A new paradigm in cardiology'
Agirbasli M. and Kerins D.M (1998) 'Glycoprotein IIb/IIIa inhibitors in acute coronary syndromes: A new paradigm in cardiology' Turkish Journal of Medical Sciences, 28 :209-218. [Details]

Peer Reviewed Journals

 YearPublication
(2014)'Trial of a novel plasma gas disinfection system (Radica) to reduce mattress residual bacterial contamination in the acute hospital setting: a preliminary study'
Shiely F, Fallon D, Casey C, Kerins DM, Eustace JA (2014) 'Trial of a novel plasma gas disinfection system (Radica) to reduce mattress residual bacterial contamination in the acute hospital setting: a preliminary study'. Journal of Hospital Infection, [Details]
(2014)'Effects of Centrally Acting Angiotensin Converting Enzyme Inhibitors on Functional Decline in Patients with Alzheimer's Disease'
O'Caoimh, R,Healy, L,Gao, Y,Svendrovski, A,Kerins, DM,Eustace, J,Kehoe, PG,Guyatt, G,Molloy, DW (2014) 'Effects of Centrally Acting Angiotensin Converting Enzyme Inhibitors on Functional Decline in Patients with Alzheimer's Disease'. Journal Of Alzheimers Disease, 40 :595-603 [DOI] [Details]
(2014)'Angiotensin converting enzyme and nitric oxide inhibitory activities of novel milk derived peptides'
Phelan, M,Khaldi, N,Shields, DC,Kerins, DM (2014) 'Angiotensin converting enzyme and nitric oxide inhibitory activities of novel milk derived peptides'. International Dairy Journal, 35 :38-42 [DOI] [Details]
(2013)'Effects of centrally acting ACE inhibitors on the rate of cognitive decline in dementia'
Gao, Y,O'Caoimh, R,Healy, L,Kerins, DM,Eustace, J,Guyatt, G,Sammon, D,Molloy, DW (2013) 'Effects of centrally acting ACE inhibitors on the rate of cognitive decline in dementia'. Bmj Open, 3 [DOI] [Details]
(2012)'In vivo impact of prodrug isosorbide-5-nicotinate-2-aspirinate on lipids and prostaglandin D-2: Is this a new immediate-release therapeutic option for niacin?'
Ledwidge, MT,Ryan, F,Kerins, DM,O'Connell, D,Cefali, G,Harmon, S,Jones, M,Gilmer, JF (2012) 'In vivo impact of prodrug isosorbide-5-nicotinate-2-aspirinate on lipids and prostaglandin D-2: Is this a new immediate-release therapeutic option for niacin?'. Atherosclerosis, 221 :478-483 [DOI] [Details]
(2011)'The potential role of milk-derived peptides in cardiovascular disease'
Phelan, Martha and Kerins, David (2011) 'The potential role of milk-derived peptides in cardiovascular disease'. Food Funct, 2 :153-167   [DOI] [Details]
(2009)'Heart rate variability during sleep in healthy term newborns in the early postnatal period'
Doyle OM, Korotchikova I, Lightbody G, Marnane W, Kerins D, Boylan GB; (2009) 'Heart rate variability during sleep in healthy term newborns in the early postnatal period'. Physiological Measurement, 30 (8):847-860 [DOI] [Details]
(2008)'Soft tissue neoplasm invading the heart with associated thrombus in a 74-year-old man'
O¿Sullivan J., Kerins D., McEneaney P., Vaughan C.; (2008) 'Soft tissue neoplasm invading the heart with associated thrombus in a 74-year-old man'. European Journal of Echocardiography, 9 :143-144 [Details]
(2008)'Massive thrombus in the aortic arch: A 59-year-old lady with an unknown familial predisposition to vascular thrombosis'
O¿Sullivan J., Kerins D., Vaughan C. ; (2008) 'Massive thrombus in the aortic arch: A 59-year-old lady with an unknown familial predisposition to vascular thrombosis'. European Journal of Echocardiography, 9 :178-180 [Details]
(2004)'S-adenosylhomocysteine is a more sensitive indicator of renal insufficiency than homocysteine'
Wagner C., Stone W.J., Koury M.J., Dupont W.D., Kerins D.M.; (2004) 'S-adenosylhomocysteine is a more sensitive indicator of renal insufficiency than homocysteine'. Nutrition Research, 24 :487-494 [Details]
(2004)'The Warfarin and Antiplatelet Therapy in Heart Failure Trial (WATCH): rationale, design, and baseline patient characteristics'
Kerins, David M; (2004) 'The Warfarin and Antiplatelet Therapy in Heart Failure Trial (WATCH): rationale, design, and baseline patient characteristics'. Journal of cardiac failure, 10 :101-112 [Details]
(2003)'The PREVENT Investigators. Long-term, low-intensity warfarin therapy for the prevention of recurrent venous thromboembolism'
Kerins, David M; (2003) 'The PREVENT Investigators. Long-term, low-intensity warfarin therapy for the prevention of recurrent venous thromboembolism'. New England Journal of Medicine, 348 :1425-1434 [Details]
(2001)'Plasma S-adenosylhomocysteine is a more sensitive marker of cardiovascular disease than plasma homocysteine'
Kerins D.M., Koury M.J., Capdevilla A., Rama S., Wagner (2001) 'Plasma S-adenosylhomocysteine is a more sensitive marker of cardiovascular disease than plasma homocysteine'. American Journal of Clinical Nutrition, 348 :1425-1434 [Details]
(2001)'Oral glycoprotein Iib/IIIa antagonism in patients with coronary artery disease'
23. Catella-Lawson F., Kapoor S., Moretti D., DeMarco S., Vigilante G.J., Cucchiara A.J., Ramsey, K.E., Combe S., Rocca S., Theroux P., FitzGerald G.A., and the AFIRME Investigators. (2001) 'Oral glycoprotein Iib/IIIa antagonism in patients with coronary artery disease'. American Journal of Cardiology, 88 :236-242 [Details]
(1999)'Isolated Rheumatic Tricuspid Stenosis with Reverse Lutembacher's Physiology'
FADEL, BAHAA M. and HIATT, BONNIE L. and KERINS, DAVID M. (1999) 'Isolated Rheumatic Tricuspid Stenosis with Reverse Lutembacher's Physiology'. European Journal of Echocardiography, 16 (6):567-573   [DOI] [Details]
(1999)'QT Dispersion is reduced after aortic valve replacement in patients with aortic stenosis'
D Darbar and C J Cherry and D M Kerins (1999) 'QT Dispersion is reduced after aortic valve replacement in patients with aortic stenosis'. Heart, 82 (1):15-18 [DOI] [Details]
(1998)'Combination hemotherapy and mortality prevention (CHAMP) study rationale and design'
19. Fiore L., Brophy M., Peduzzi P., Lu D., Sacco J., Colling C., Ezekowitz (1998) 'Combination hemotherapy and mortality prevention (CHAMP) study rationale and design'. Journal of Thrombosis and Thrombolysis, 6 (2):133-140 [Details]
(1998)'Liver regeneration is transiently impaired in urokinase-deficient mice'
William E. Russell (1998) 'Liver regeneration is transiently impaired in urokinase-deficient mice'. American Journal of Physiology - Gastrointestinal and Liver Physiology, 275 (6)   [Details]
(1998)'Signal transduction of the urokinase-type plasminogen activator receptor: Enhancement of tyrosine phosphorylation of focal adhesion proteins and activation of MAP kinase'
Tang H*., Kerins D.M.*, Hao Q., Inagami T., Vaughan, D.E (1998) 'Signal transduction of the urokinase-type plasminogen activator receptor: Enhancement of tyrosine phosphorylation of focal adhesion proteins and activation of MAP kinase'. Journal of Biological Chemistry, 273 :18268-18272 [DOI] [Details]
(1997)'Optimal Albunex dosing for enhancement of Doppler tricuspid regurgitation'
14. Kemp W.E., Kerins D.M., Shyr Y., Byrd III, B.F (1997) 'Optimal Albunex dosing for enhancement of Doppler tricuspid regurgitation'. American Journal of Cardiology, 79 :232-234 [Details]
(1997)'Diagnosing left ventricular dysfunction after myocardial infarction: the Dundee algorithm'
Darbar, D and Gillespie, N and Choy, A M and Lang, C C and Pringle, S D and Pringle, T H and Kerins, D M and McNeill, G P and Struthers, A D (1997) 'Diagnosing left ventricular dysfunction after myocardial infarction: the Dundee algorithm'. QJM, 90 (11):677-683   [DOI] [Details]
(1995)'Angiotensin induction of PAI-1 expression in endothelial cells is mediated by the hexapeptide angiotensin IV'
D M Kerins AND Q Hao AND D E Vaughan (1995) 'Angiotensin induction of PAI-1 expression in endothelial cells is mediated by the hexapeptide angiotensin IV'. The Journal of Clinical Investigation, 96 (5):2515-2520   [DOI] [Details]
(1994)'Doppler Echocardiography in Cardiac Tamponade and Constrictive Pericarditis'
ZHANG, SHAOWEN and KERINS, DAVID M. and III, BENJAMIN F. BYRD (1994) 'Doppler Echocardiography in Cardiac Tamponade and Constrictive Pericarditis'. Echocardiography, 11 (5):507-521   [DOI] [Details]
(1994)'Role of the perfluorocarbon Fluosol-DA in the setting of coronary angioplasty'
Kerins D.M. (1994) 'Role of the perfluorocarbon Fluosol-DA in the setting of coronary angioplasty'. The American Journal of The Medical Sciences, 307 :218-221 [Details]
(1992)'Pharmacokinetics of tissue-type plasminogen activator during acute myocardial infarction in men. Effect of a prostacyclin analogue'
D M Kerins; L Roy; S Kunitada; A Adedoyin; G A FitzGerald; D J Fitzgerald (1992) 'Pharmacokinetics of tissue-type plasminogen activator during acute myocardial infarction in men. Effect of a prostacyclin analogue'. Circulation, 85 :526-532 [DOI] [Details]
(1991)'Effects of intravenous adenosine on tissue type plasminogen activator pharmacokinetics in humans'
Velasco C.E. and Kerins D.M. and Howe D. and Fitzgerald D.J., and Forman M.B (1991) 'Effects of intravenous adenosine on tissue type plasminogen activator pharmacokinetics in humans'. Coronary Artery Disease, 2 :1069-1075 [Details]
(1991)'Ampicillin/sulbactam--a combination of an old and a new agent in the treatment of infection'
Kerins,DM (1991) 'Ampicillin/sulbactam--a combination of an old and a new agent in the treatment of infection'. The American Journal of The Medical Sciences, 301 (6)   [Details]
(1991)'A prostacyclin analog impairs the response to tissue-type plasminogen activator during coronary thrombolysis: Evidence for a pharmacokinetic interaction'
Kerins D.M., Shuh M., Kunitada S., FitzGerald G.A., & Fitzgerald D.J. (1991) 'A prostacyclin analog impairs the response to tissue-type plasminogen activator during coronary thrombolysis: Evidence for a pharmacokinetic interaction'. Journal of Pharmacology and Experimental Therapeutics, 257 :487-492 [Details]
(1991)'The current role of platelet-active drugs in ischaemic heart disease'
Kerins D.M., & FitzGerald G.A. (1991) 'The current role of platelet-active drugs in ischaemic heart disease'. Drugs, 41 (5):665-671 [DOI] [Details]
(1989)'Platelet and vascular function during coronary thrombolysis with tissue-type plasminogen activator'
Kerins D.M., Roy L., FitzGerald G.A., & Fitzgerald D.J. (1989) 'Platelet and vascular function during coronary thrombolysis with tissue-type plasminogen activator'. Circulation, 80 :1718-1725 [DOI] [Details]
(2014)'Exercise and associated dietary extremes impact on gut microbial diversity'
Clarke SF, Murphy EF,O’Sullivan O, Lucey AJ,Humphreys M, Hogan A, Hayes P, O’Reilly M,Jeffery IB, Wood-Martin R, Kerins DM, Quigley E, Ross RP, O’Toole PW, Molloy MG, Falvey E, Shanahan F, Cotter PD (2014) 'Exercise and associated dietary extremes impact on gut microbial diversity'. Gut, [Details]

Abstract

 YearPublication
(2014)Hospital Acquired Anaemia Due to Phlebotomy in Patients with Acute Myocardial Infarction and Angina Pectoris in a Cork Hospital.
Bourke, RH,Kerins, DM (2014) Hospital Acquired Anaemia Due to Phlebotomy in Patients with Acute Myocardial Infarction and Angina Pectoris in a Cork Hospital. Abstract [Details]
(2013)Diastolic dysfunction in rheumatoid arthritis patients without cardiovascular symptoms is associated with presence of microalbuminuria and subclinical peripheral vascular disease.
O'Sullivan, M,Murray, O,Daly, M,Harney, S,Kerins, DM (2013) Diastolic dysfunction in rheumatoid arthritis patients without cardiovascular symptoms is associated with presence of microalbuminuria and subclinical peripheral vascular disease. Abstract [Details]

Professional Activities

Honours and Awards

 YearTitleAwarding Body
2003Outstanding Lecturer Award Department of Pharmacology, Vanderbilt University
2007Certificate of Merit Educational Exhibit Radiological Society of North America Annual Scientific Meeting, Chicago IL
2007Excellence in Design Award Radiological Society of North America Annual Scientific Meeting, Chicago IL

Committees

 CommitteeFunctionFrom / To
Irish Medicines Board Member2006 /
National Committee on Medical Education and Training Member2007 /

Employment

 EmployerPositionFrom / To
University College Cork Dean, School of Medicine01-FEB-06 /
Vanderbilt University Associate Professor of Medicine01-JAN-01 / 01-JAN-06
Vanderbilt University Assistant Professor of Medicine01-JAN-93 / 01-JAN-01
Nashville VA Medical Center Chief, Cardiology Section01-JAN-99 / 01-JAN-03
Mercy University Hospital Clinical Director03-SEP-12 / 31-AUG-15

Education

 YearInstitutionQualificationSubject
1984University College Cork MB BAO BCHMedicine
1981University College Cork BScunknown

Teaching Activities

Teaching Interests

My interests are in the area of cardiovascular pharmacology with an specific interest in antiplatelet therapy, and in the interactions of the renin angiotensin system and the fibrinolytic pathways. I have a clinical interest in non-invasive cardiac imaging. 

Contact details

  • David Kerins
    Professor Therapeutics
  • d.kerins@ucc.ie
  • Department of Pharmacology and Therapeutics
    Western Gateway Building
    UCC
  • 021-420-5448

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Department of Pharmacology and Therapeutics

Cógaseolaíocht agus Teiripic

2nd Floor, Western Gateway Building, University College Cork, Cork

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