UCC Research Profiles: O.Barry@ucc.ie, Pharmacology & Therapeutics

Contact Details

Lecturer
Pharmacology & Therapeutics
University College Cork
Cork
Ireland

T: +353-21-490-3000
F: +353 21 490 1259
E: O.Barry@ucc.ie
W: http://www.ucc.ie/

Pharmacology & Therapeutics
Department of Pharmcology & Therape
UCC

T: +353 21 4205493
E: O.Barry@ucc.ie

Biography

Provide a brief statement as to the impact on the discipline of the research carried out by you and its context.

Our laboratory focuses on the study of different families of serine/threonine kinases that play key roles in signalling mechanisms following activation of seven-transmembrane and tyrosine-kinase receptors. In particular our area of research focuses on the role of Paks, p38 MAPKs, and PKCs which exert a variety of cellular effects including changes in proliferation, malignant transformation, cell death and differentiation. Briefly, we have exploited the activation of PKC as a pro-apoptotic and anti-proliferative agent in oesophageal cancer. In addition we have re-introduced p38 delta MAPK into different cancers which lack this isoform including oesophageal, renal, prostate, lung and liver which has profound effects on cell proliferation and apoptosis. Finally, we have identified different Pak isoforms which are pro-apoptotic in oesophageal and renal cancer. An important aspect of our research is to elucidate the signalling pathways underlying the apoptotic effect of these kinases using both pharmacological and molecular strategies. In addition the use of athymic nude mice to study their effects is necessary to translate in vitro results to in vivo models of tumourigenesis in order to validate our experimental hypothesis in a physiological setting. In fact we have recently reported that inhibition of Pak1 can totally abrogate the growth of renal tumours in mice. The identification of different kinase isoforms involved in cell proliferation and cell death in different types of cancer may have important therapeutic implications for the treatment of the disease.
The aim within my laboratory is to train future investigators in an intellectually exciting and supportive work environment to carry out independent, high quality research. Our goal is to educate undergraduate, PhDs and post-doctoral fellows to a level where they have the research knowledge, understanding, critical analytical skills, and the know how to apply appropriate experimental design and state-of-the-art techniques to whatever emerging questions they are attempting to address. In summary, we concentrate on developing analytical, technical and interpersonal skills.
Our laboratory strives to train research scientists in cancer cell and molecular biology focusing on the pharmacological principles of how drugs work and why some are toxic. Our research is conducted at the molecular, cellular, organ, whole organism, and clinical levels. Thus, through individual research driven projects within the department in conjunction with national and international collaborative groups we provide abundant educational opportunities in the broader area of Pharmacology for both undergraduate and postgraduate students.

Research Interests

Provide a brief statement as to the impact on the discipline of the research carried out by you and its context.

Our laboratory focuses on the study of different families of serine/threonine kinases that play key roles in signalling mechanisms following activation of seven-transmembrane and tyrosine-kinase receptors. In particular our area of research focuses on the role of Paks, p38 MAPKs, and PKCs which exert a variety of cellular effects including changes in proliferation, malignant transformation, cell death and differentiation. Briefly, we have exploited the activation of PKC as a pro-apoptotic and anti-proliferative agent in oesophageal cancer. In addition we have re-introduced p38delta MAPK into different cancers which lack this isoform including oesophageal, renal, prostate, lung and liver which has profound effects on cell proliferation and apoptosis. Finally, we have identified different Pak isoforms which are pro-apoptotic in oesophageal and renal cancer. An important aspect of our research is to elucidate the signalling pathways underlying the apoptotic effect of these kinases using both pharmacological and molecular strategies. In addition the use of athymic nude mice to study their effects is necessary to translate in vitro results to in vivo models of tumourigenesis in order to validate our experimental hypothesis in a physiological setting. In fact we have recently reported that inhibition of Pak1 can totally abrogate the growth of renal tumours in mice. The identification of different kinase isoforms involved in cell proliferation and cell death in different types of cancer may have important therapeutic implications for the treatment of the disease.
The aim within my laboratory is to train future investigators in an intellectually exciting and supportive work environment to carry out independent, high quality research. Our goal is to educate undergraduate, PhDs and post-doctoral fellows to a level where they have the research knowledge, understanding, critical analytical skills, and the know how to apply appropriate experimental design and state-of-the-art techniques to whatever emerging questions they are attempting to address. In summary, we concentrate on developing analytical, technical and interpersonal skills.
Our laboratory strives to train research scientists in cancer cell and molecular biology focusing on the pharmacological principles of how drugs work and why some are toxic. Our research is conducted at the molecular, cellular, organ, whole organism, and clinical levels. Thus, through individual research driven projects within the department in conjunction with national and international collaborative groups we provide abundant educational opportunities in the broader area of Pharmacology for both undergraduate and postgraduate students.

Research Grants

	Project	Funding Body	Start Date	End Date	Award
	[M.Sc. Medicine] {Barry Dr. Orla} N	Miscellaneous	01-OCT-03	30-SEP-05	€33,000.00
	Targeting p38delta MAPK in oesophageal cancer, a possible future therapeutic goal?	Health Research Board	01-SEP-10	31-AUG-14	€184,003.00

Publications

Book Chapters

	Year	Publication
	(2011)	'Exploitation of aberrant signalling pathways as useful targets for renal clear cell carcinoma therapy' Orla Patricia Barry and Carol O' Callaghan; (2011) 'Exploitation of aberrant signalling pathways as useful targets for renal clear cell carcinoma therapy' In: Renal Cancer. Croatia: InTECH. [Details]
	(1997)	'Urinary 8-Epi PGF2:An Index Of Oxidant Stress In Vivo. In: Fibrinolysis and Protelysis' M.P. Reilly, P. Barry, J.A. Lawson, and G.A.FitzGerald; (1997) 'Urinary 8-Epi PGF2:An Index Of Oxidant Stress In Vivo. In: Fibrinolysis and Protelysis' In: Urinary 8-Epi PGF2:An Index Of Oxidant Stress In Vivo. In: Fibrinolysis and Protelysis. : . [Details]
	(1997)	'Markers Of Platelet Activation And Oxidant Stress In Atherothrombotic Disease. In: Thrombosis and Haemostasis' Garret A. FitzGerald, Jessica Tigges and Patricia Barry, and John A. Lawson. ; (1997) 'Markers Of Platelet Activation And Oxidant Stress In Atherothrombotic Disease. In: Thrombosis and Haemostasis' In: Markers Of Platelet Activation And Oxidant Stress In Atherothrombotic Disease. In: Thrombosis and Haemostasis. : . [Details]

Peer Reviewed Journals

	Year	Publication
	(2016)	'Pregnancy-specific glycoprotein expression in normal gastrointestinal tract and in tumors detected with novel monoclonal antibodies' Aileen Houston, John M. Williams, Tihana Lenac Rovis, Daniel K. Shanley, Ronan T. O'Riordan, Patrick A. Kiely, Melanie Ball, Orla P. Barry, Jacquie Kelly, Aine Fanning, John MacSharry, Ofer Mandelboim, Bernhard B. Singer, Stipan Jonjic & Tom Moore (2016) 'Pregnancy-specific glycoprotein expression in normal gastrointestinal tract and in tumors detected with novel monoclonal antibodies'. mAbs, 8 (2):405-413 [Details]
	(2015)	'p38δ MAPK phenotype: an indicator of chemotherapeutic response in oesophageal squamous cell carcinoma' O' Callaghan C, Fanning LJ, Barry OP (2015) 'p38δ MAPK phenotype: an indicator of chemotherapeutic response in oesophageal squamous cell carcinoma'. Anti Cancer Drugs, [Details]
	(2015)	'Periodic review sessions contribute to student learning across the disciplines in pharmacology' Barry, O.P., O'Sullivan, E. and McCarthy, M. (2015) 'Periodic review sessions contribute to student learning across the disciplines in pharmacology'. Journal of The Scholarship of Teaching and Learning, [Details]
	(2014)	'p38&#55349;&#57087; MAPK: Emerging Roles of a Neglected Isoform. International Journal of Cell Biology' O' Callaghan C, Fanning LJ, Barry OP (2014) 'p38&#55349;&#57087; MAPK: Emerging Roles of a Neglected Isoform. International Journal of Cell Biology'. International Journal of Cell Biology, [Details]
	(2013)	'Loss of p38δ mitogen-activated protein kinase expression promotes oesophageal squamous cell carcinoma proliferation, migration and anchorage-independent growth' O'Callagahan C, Fanning LJ, Houston A and Barry OP. (2013) 'Loss of p38δ mitogen-activated protein kinase expression promotes oesophageal squamous cell carcinoma proliferation, migration and anchorage-independent growth'. International Journal of Oncology, [Details]
	(2007)	'Modulation of p21-activated kinase 1 alters the behavior of renal cell carcinoma. Int J Cancer' O'Sullivan GC, Tangney M, Casey G, Ambrose M, Houston A and Barry OP. ; (2007) 'Modulation of p21-activated kinase 1 alters the behavior of renal cell carcinoma. Int J Cancer'. International Journal of Cancer, [Details]
	(2007)	'Modulation of p21-activated kinase 1 alters the behavior of renal cell carcinoma' O'Sullivan, G. C.,Tangney, M.,Casey, G.,Ambrose, M.,Houston, A.,Barry, O. P.; (2007) 'Modulation of p21-activated kinase 1 alters the behavior of renal cell carcinoma'. Int J Cancer, 121 (99):1930-401930 [Details]
	(2006)	'Induction of apoptosis in renal cell carcinoma by reactive oxygen species: involvement of extracellular signal-regulated kinase 1/2, p38delta/gamma, cyclooxygenase-2 down-regulation, and translocation of apoptosis-inducing factor' Ambrose M, Ryan A, O¿ Sullivan GC, Dunne C, and Barry OP; (2006) 'Induction of apoptosis in renal cell carcinoma by reactive oxygen species: involvement of extracellular signal-regulated kinase 1/2, p38delta/gamma, cyclooxygenase-2 down-regulation, and translocation of apoptosis-inducing factor'. Mol Pharmacol, [Details]
	(2001)	'Effects of Vitamin E on Lipid Peroxidation in Healthy Persons' Emma A. Meagher, Orla P. Barry, John A. Lawson, Joshua Rokach, and Garret A. FitzGerald; (2001) 'Effects of Vitamin E on Lipid Peroxidation in Healthy Persons'. JAMA : the journal of the American Medical Association, [Details]
	(2001)	'Protein Kinase C Isozymes, Novel Phorbol Ester Receptors and Cancer Chemotherapy' Barry, O.P., and Kazanietz, M.G; (2001) 'Protein Kinase C Isozymes, Novel Phorbol Ester Receptors and Cancer Chemotherapy'. Curr. Pharm. Des, [Details]
	(2001)	'Constitutive ERK1/2 activation in esophagogastric rib bone marrow micrometastatic cells is MEK-independent' Barry, O. P.,Mullan, B.,Sheehan, D.,Kazanietz, M. G.,Shanahan, F.,Collins, J. K.,O'Sullivan, G. C. (2001) 'Constitutive ERK1/2 activation in esophagogastric rib bone marrow micrometastatic cells is MEK-independent'. Journal of Biological Chemistry, 276 (181):15537-15546 [Details]
	(1999)	'Increased Oxidant Stress In Alcohol Liver Disease' Emma A. Meagher, Orla P. Barry, Anne Burke, Michael R. Lucey, Joshua Rokach, and Garret A. FitzGerald; (1999) 'Increased Oxidant Stress In Alcohol Liver Disease'. J. Clin. Invest, [Details]
	(1999)	'Iron-Dependent Human Platelet Activation And Hydroxyl Radical Formation' Domenico Pratico, Orla P. Barry, Andrea Ghiselli, Luigi Iuliano, Guiseppi Sabatino, Garret A. FitzGerald, and Francesco Violi. ; (1999) 'Iron-Dependent Human Platelet Activation And Hydroxyl Radical Formation'. Circulation, 99, [Details]
	(1999)	'Arachidonic Acid in Platelet Microparticles Upregulates Cyclooxygenase-2 Dependent Prostaglandin Formation Via a Protein Kinase C/Mitogen-Activated Protein Kinase-Dependent Pathway' Orla P. Barry, Marcelo G. Kazanietz, Domenico Pratico, and Garret A. FitzGerald. ; (1999) 'Arachidonic Acid in Platelet Microparticles Upregulates Cyclooxygenase-2 Dependent Prostaglandin Formation Via a Protein Kinase C/Mitogen-Activated Protein Kinase-Dependent Pathway'. J. Biol. Chem, [Details]
	(1999)	'Alcohol-induced generation of lipid peroxidation products in humans' Meagher, E.A., Barry, O.P., Burke, A., Lucey, M.R., Lawson, J.A., Rokach, J. and FitzGerald, G.A. (1999) 'Alcohol-induced generation of lipid peroxidation products in humans'. Journal of Clinical Investigation, [Details]
	(1999)	'Mechanisms Of Cellular Activation By Platelet Microparticles' Orla P. Barry and Garret A. FitzGerald.; (1999) 'Mechanisms Of Cellular Activation By Platelet Microparticles'. Thrombosis and Haemostasis, [Details]
	(1998)	'IPF2 Alpha-1:An Index Of Lipid Peroxidation In Humans' Domenico Pratico, ¶Orla P. Barry, John A. Lawson, Mustafa Adiyaman, Seong-Woo Huang, Subash P. Khanapure, Luigi Iuliano, Joshua Rokach, and Garret A. FitzGerald.; (1998) 'IPF2 Alpha-1:An Index Of Lipid Peroxidation In Humans'. Proceedings of the National Academy of Science, [Details]
	(1998)	'Modulation Of Monocyte-Endothelial Cell Interactions By Platelet Microparticles' Orla P. Barry, Domenico Pratico, Rashmin C. Savani, and Garret A. FitzGerald. ; (1998) 'Modulation Of Monocyte-Endothelial Cell Interactions By Platelet Microparticles'. J. Clin. Invest, [Details]
	(1998)	'Effects of chronic therapy with vitamin E on lipid peroxidation in vivo in healthy humans' Meagher, E.A., Barry, O.P., Bensinger, S., Rokach, J. and FitzGerald, G.A. (1998) 'Effects of chronic therapy with vitamin E on lipid peroxidation in vivo in healthy humans'. Journal of investigative medicine : the official publication of the American Federation for Clinical Research, [Details]
	(1997)	'Transcellular Activation Of Platelets And Endothelial Cells By Bioactive Lipids In Platelet Microparticles' Orla P. Barry, Domenico Pratico, John A. Lawson, and Garret A. Fitzgerald. ; (1997) 'Transcellular Activation Of Platelets And Endothelial Cells By Bioactive Lipids In Platelet Microparticles'. J. Clin. Invest, [Details]
	(1997)	'Urinary excretion of IPF2 alpha-1 and 8-epi PGF(2 alpha): Specific analysis of distinct F-2 isoprostanes as noninvasive indices of oxidant stress in vivo' Pratico, D., Barry, O.P., Lawson, J.A., Rokach, J, and FitzGerald, G.A. (1997) 'Urinary excretion of IPF2 alpha-1 and 8-epi PGF(2 alpha): Specific analysis of distinct F-2 isoprostanes as noninvasive indices of oxidant stress in vivo'. Circulation, [Details]
	(1997)	'Dietary Factors In Thrombosis And Haemostasis:Summary And Conclusions' Garret A. FitzGerald and Patricia Barry; (1997) 'Dietary Factors In Thrombosis And Haemostasis:Summary And Conclusions'. Am. J. Clin. Nutr, [Details]
	(1997)	'Platelet microparticles stimulate adhesion and migration of monocytes in a PKC-dependent manner' Barry, O.P., Pratico, D., Savani, R.C. and FitzGerald, G.A. (1997) 'Platelet microparticles stimulate adhesion and migration of monocytes in a PKC-dependent manner'. Circulation, [Details]
	(1996)	'Transcellular signaling by platelet microvesicles in human endothelial cells and platelets' Barry, O.P., Pratico, D. and FitzGerald, G.A. (1996) 'Transcellular signaling by platelet microvesicles in human endothelial cells and platelets'. Circulation, [Details]

Conference Publications

	Year	Publication
	(2013)	104th Annual Meeting of the American-Association-for-Cancer-Research (AACR) O' Callaghan, C., Fanning, L., Houston, A. and Barry, O.P. (2013) New paradigms for the modulatory actions of p38 delta MAPK restorative expression in esophageal squamous cancer cell growth, migration and response to chemotherapy: A possibel future therapeutic target 104th Annual Meeting of the American-Association-for-Cancer-Research (AACR) [Details]
	(2012)	24th EORTC-NCI-AACR symposium on molecular targets and cancer therapeutics O'Callaghan, C., Fanning, L., Houston, A. and Barry, O.P. (2012) Targeting p38 delta MAPK in oesophageal cancer: a possible future therapeutic goal? 24th EORTC-NCI-AACR symposium on molecular targets and cancer therapeutics [Details]
	(2005)	96th Annual Meeting of the American-Association-for-Cancer-Research Ambrose, M., Ryan, A., Dunne, C., O' Sullivan, G. and Barry, O.P. (2005) Induction of apoptosis in 786-0 renal cell carcinoma by reactive oxygen species is ERK1/2-, p38 delta and gamma MAPK- and Pak-1-independent but JNK-independent 96th Annual Meeting of the American-Association-for-Cancer-Research [Details]
	(1999)	Gastroenterology and Haematology Meagher, E.A., Barry, O.P., Lucey, M.R., Rokach, J. and FitzGerald, GA. (1999) Antioxidant modulation of free radical generation in cirrhosis Gastroenterology and Haematology [Details]
	(1996)	69th Scientific Sessions of the American Heart Association Barry, O.P., Pratico, D. and FitzGerald, G.A. (1996) Transcellular signaling by platelet micovesicles in human endothelial cells and platelets 69th Scientific Sessions of the American Heart Association [Details]
	(1997)	Annual Meeting of the Association of American Physicians, the American Society for Clinical Investigation, and the American Federation for Medical Research: Biomedicine '97 Medical Research from Bench to Bedside Barry, O.P., Pratico, D. and FitzGerald, G.A. (1997) Platelet mircoparticles enhance adhesive interactions between monocytes and endothelial cells Annual Meeting of the Association of American Physicians, the American Society for Clinical Investigation, and the American Federation for Medical Research: Biomedicine '97 Medical Research from Bench to Bedside [Details]
	(1998)	71st Scientific Sessions of the American Heart Association Pratico, D., Luliano, L., Ferro, D., Barry, O.P., Valesini, G., Rokach, J., FitzGerald, G.A. and Violi, F. (1998) Ongoing thrombotic state in patients with antiphospholipid antibodies: a role for increased lipid peroxidation 71st Scientific Sessions of the American Heart Association [Details]
	(1998)	18th Annual Meeting of the Society of Perinatal Obstetricians Regan, C., Barry, O.P., Lawson, J.A., Morgan, M.A. and FitzGerald, G.A. (1998) Isoprostane formation in normal pregnancy 18th Annual Meeting of the Society of Perinatal Obstetricians [Details]

Professional Activities

Honours and Awards

Year	Title	Awarding Body
2008	A finalist in the JMS Doctor Awards Oncology section.	JMS Doctor Awards, Health Research Board & Eireann Healthcare Publications, Dublin.
2002	Overall winner of the JMS Doctor Awards	JMS Doctor Awards, Health Research Board & Eireann Healthcare Publications, Dublin.
1998	Trainee Investigator Award for Excellence in Scientific Research.	Biomedicine, Washington DC, USA
1997	Trainee Investigator Award for Excellence in Scientific Research.	Biomedicine, Washington DC, USA

Conference Contributions

	Year	Publication
	(2008)	¿Targeting Oesophageal Cancer with p38d MAPK: a possible future therapeutic target?¿, O. Barry; (2008) ¿Targeting Oesophageal Cancer with p38d MAPK: a possible future therapeutic target?¿. [Oral Presentation], ¿Targeting Oesophageal Cancer with p38d MAPK: a possible future therapeutic target?¿, PhD Scholars Cancer Research Programme, National University of Ireland, Cork , 01-JAN-08 - 01-JAN-08. [Details]
	(2008)	Targeting Oesophageal Cancer with p38d MAPK: a possible future therapeutic target?¿, O. Barry; (2008) Targeting Oesophageal Cancer with p38d MAPK: a possible future therapeutic target?¿. [Oral Presentation], Targeting Oesophageal Cancer with p38d MAPK: a possible future therapeutic target?¿, PhD Scholars Cancer Research Programme, National University of Ireland, Cork , 01-JAN-08 - 01-JAN-08. [Details]
	(2006)	Targeting oesophageal, renal and prostate cancer with p38 MAPK: a possible future therapeutic approach?¿, O. Barry; (2006) Targeting oesophageal, renal and prostate cancer with p38 MAPK: a possible future therapeutic approach?¿. [Oral Presentation], Targeting oesophageal, renal and prostate cancer with p38 MAPK: a possible future therapeutic approach?¿, Cork Cancer Research Open Day, Ireland , 01-JAN-06 - 01-JAN-06. [Details]
	(2004)	From Bench to Bedside, Lecture series. ¿Targeting oesophageal cancer with siRNA Paks: a possible future therapeutic target?¿, O. Barry; (2004) From Bench to Bedside, Lecture series. ¿Targeting oesophageal cancer with siRNA Paks: a possible future therapeutic target?¿. [Oral Presentation], From Bench to Bedside, Lecture series. ¿Targeting oesophageal cancer with siRNA Paks: a possible future therapeutic target?¿, Mercy University Hospital, Cork , 01-JAN-04 - 01-JAN-04. [Details]
	(2004)	Cork Cancer Research Open Day, Cork, Ireland. ¿An investigation of the role(s) of kinases in oesophageal and renal carcinogenesis¿, O. Barry; (2004) Cork Cancer Research Open Day, Cork, Ireland. ¿An investigation of the role(s) of kinases in oesophageal and renal carcinogenesis¿. [Oral Presentation], Cork Cancer Research Open Day, Cork, Ireland. ¿An investigation of the role(s) of kinases in oesophageal and renal carcinogenesis¿, Mercy University Hospital, Cork , 01-JAN-04 - 01-JAN-04. [Details]
	(2004)	Induction of apoptosis in 786-0 Renal Cell Carcinoma by Reactive Oxygen Species is ERK1/2, Pak-1 and p38 MAPK  and --dependent but JNK-independent¿, O. Barry; (2004) Induction of apoptosis in 786-0 Renal Cell Carcinoma by Reactive Oxygen Species is ERK1/2, Pak-1 and p38 MAPK  and --dependent but JNK-independent¿. [Oral Presentation], Induction of apoptosis in 786-0 Renal Cell Carcinoma by Reactive Oxygen Species is ERK1/2, Pak-1 and p38 MAPK  and --dependent but JNK-independent¿, National University of Ireland, Cork, Medical Research Open Day , 01-JAN-04 - 01-JAN-04. [Details]
	(2004)	¿Targeting oesophageal cancer with siRNA Paks: a possible future therapeutic target?¿, O. Barry; (2004) ¿Targeting oesophageal cancer with siRNA Paks: a possible future therapeutic target?¿. [Oral Presentation], ¿Targeting oesophageal cancer with siRNA Paks: a possible future therapeutic target?¿, From Bench to Bedside¿ Lecture series, Mercy Hospital Cork, Ireland , 01-JAN-04 - 01-JAN-04. [Details]
	(2004)	An investigation of the role(s) of kinases in oesophageal and renal carcinogenesis¿, O. Barry; (2004) An investigation of the role(s) of kinases in oesophageal and renal carcinogenesis¿. [Oral Presentation], An investigation of the role(s) of kinases in oesophageal and renal carcinogenesis¿, Cork Cancer Research Open Day, Ireland , 01-JAN-04 - 01-JAN-04. [Details]
	(2002)	Detection of Bone Marrow Micrometastasis Following Bone Neoadjuvant Chemoradiotherapy In Patients with Esophagogastric Malignancy¿, O. Barry; (2002) Detection of Bone Marrow Micrometastasis Following Bone Neoadjuvant Chemoradiotherapy In Patients with Esophagogastric Malignancy¿. [Oral Presentation], Detection of Bone Marrow Micrometastasis Following Bone Neoadjuvant Chemoradiotherapy In Patients with Esophagogastric Malignancy¿, AACR American Association for Cancer Research, 93rd Annual Meeting, San Francisco, California , 01-JAN-02 - 01-JAN-02. [Details]
	(2001)	Deparment of Biochemistry Seminar, Lee Maltings. ¿Characterisation and Manipulation of Mitogenic Signalling Cascades in Esophagogastric Micrometastatic Cancer¿, O. Barry; (2001) Deparment of Biochemistry Seminar, Lee Maltings. ¿Characterisation and Manipulation of Mitogenic Signalling Cascades in Esophagogastric Micrometastatic Cancer¿. [Oral Presentation], Deparment of Biochemistry Seminar, Lee Maltings. ¿Characterisation and Manipulation of Mitogenic Signalling Cascades in Esophagogastric Micrometastatic Cancer¿, National University of Ireland, Cork , 01-JAN-01 - 01-JAN-01. [Details]
	(2001)	Characterisation and Manipulation of Mitogenic Signalling Cascades in Esophagogastric Micrometastatic Cancer, O. Barry; (2001) Characterisation and Manipulation of Mitogenic Signalling Cascades in Esophagogastric Micrometastatic Cancer. [Oral Presentation], Characterisation and Manipulation of Mitogenic Signalling Cascades in Esophagogastric Micrometastatic Cancer, Deparment of Biochemistry Seminar, Lee Maltings, National University of Ireland, Cork , 01-JAN-01 - 01-JAN-01. [Details]
	(2001)	Constitutive ERK1/2 Activation In Esophagogastric Rib Bone Marrow Micrometastatic Cells is MEK-Independent¿, O. Barry; (2001) Constitutive ERK1/2 Activation In Esophagogastric Rib Bone Marrow Micrometastatic Cells is MEK-Independent¿. [Oral Presentation], Constitutive ERK1/2 Activation In Esophagogastric Rib Bone Marrow Micrometastatic Cells is MEK-Independent¿, AACR American Association for Cancer Research, 92rd Annual Meeting, San Francisco, California , 01-JAN-01 - 01-JAN-01. [Details]
	(2000)	¿Constitutive ERK1/2 Activation In Esophagogastric Rib Bone Marrow Micrometastatic Cells is MEK-Independent, O. Barry; (2000) ¿Constitutive ERK1/2 Activation In Esophagogastric Rib Bone Marrow Micrometastatic Cells is MEK-Independent. [Oral Presentation], ¿Constitutive ERK1/2 Activation In Esophagogastric Rib Bone Marrow Micrometastatic Cells is MEK-Independent, SYNCAN EU Program, ¿00, Florence, Italy , 01-JAN-00 - 01-JAN-00. [Details]
	(2000)	SYNCAN EU Program, ¿00, Florence, Italy. ¿Constitutive ERK1/2 Activation In Esophagogastric Rib Bone Marrow Micrometastatic Cells is MEK-Independent¿, O. Barry; (2000) SYNCAN EU Program, ¿00, Florence, Italy. ¿Constitutive ERK1/2 Activation In Esophagogastric Rib Bone Marrow Micrometastatic Cells is MEK-Independent¿. [Oral Presentation], SYNCAN EU Program, ¿00, Florence, Italy. ¿Constitutive ERK1/2 Activation In Esophagogastric Rib Bone Marrow Micrometastatic Cells is MEK-Independent¿, Florence, Italy , 01-JAN-00 - 01-JAN-00. [Details]
	(1998)	Signal Transduction and Lipid Second Messenger III, Keystone Symposia. ¿Signal Transduction Pathways Induced by the Transcellular Delivery of Platelet Microparticle Arachidonic Acid¿, O. Barry; (1998) Signal Transduction and Lipid Second Messenger III, Keystone Symposia. ¿Signal Transduction Pathways Induced by the Transcellular Delivery of Platelet Microparticle Arachidonic Acid¿. [Oral Presentation], Signal Transduction and Lipid Second Messenger III, Keystone Symposia. ¿Signal Transduction Pathways Induced by the Transcellular Delivery of Platelet Microparticle Arachidonic Acid¿, Toas, New Mexico, USA , 01-JAN-98 - 01-JAN-98. [Details]
	(1998)	Signal Transduction Retreat. ¿Arachidonic Acid in Platelet Microparticles Upregulates Cyclooxygenase-2 Dependent Prostaglandin Formation Via a PKC/MAPK-Dependent Pathway¿, O. Barry; (1998) Signal Transduction Retreat. ¿Arachidonic Acid in Platelet Microparticles Upregulates Cyclooxygenase-2 Dependent Prostaglandin Formation Via a PKC/MAPK-Dependent Pathway¿. [Oral Presentation], Signal Transduction Retreat. ¿Arachidonic Acid in Platelet Microparticles Upregulates Cyclooxygenase-2 Dependent Prostaglandin Formation Via a PKC/MAPK-Dependent Pathway¿, Philadelphia, USA , 01-JAN-98 - 01-JAN-98. [Details]
	(1998)	Signal Transduction Pathways Induced by the Transcellular Delivery of Platelet Microparticle Arachidonic Acid¿, O. Barry; (1998) Signal Transduction Pathways Induced by the Transcellular Delivery of Platelet Microparticle Arachidonic Acid¿. [Oral Presentation], Signal Transduction Pathways Induced by the Transcellular Delivery of Platelet Microparticle Arachidonic Acid¿, Signal Transduction and Lipid Second Messenger III, Keystone Symposia, Toas, New Mexico, USA , 01-JAN-98 - 01-JAN-98. [Details]
	(1998)	Arachidonic Acid in Platelet Microparticles Upregulates Cyclooxygenase-2 Dependent Prostaglandin Formation Via a PKC/MAPK-Dependent Pathway¿, O. Barry; (1998) Arachidonic Acid in Platelet Microparticles Upregulates Cyclooxygenase-2 Dependent Prostaglandin Formation Via a PKC/MAPK-Dependent Pathway¿. [Oral Presentation], Arachidonic Acid in Platelet Microparticles Upregulates Cyclooxygenase-2 Dependent Prostaglandin Formation Via a PKC/MAPK-Dependent Pathway¿, Signal Transduction Retreat, Philadelphia, USA , 01-JAN-98 - 01-JAN-98. [Details]
	(1997)	Platelet Microparticles Stimulate Adhesion and Migration of Monocytes in a PKC-Dependent Manner¿, O. Barry; (1997) Platelet Microparticles Stimulate Adhesion and Migration of Monocytes in a PKC-Dependent Manner¿. [Oral Presentation], Platelet Microparticles Stimulate Adhesion and Migration of Monocytes in a PKC-Dependent Manner¿, American Heart Association, Florida, USA , 01-JAN-97 - 01-JAN-97. [Details]
	(1997)	American Heart Association. ¿Platelet Microparticles Stimulate Adhesion and Migration of Monocytes in a PKC-Dependent Manner¿, O. Barry; (1997) American Heart Association. ¿Platelet Microparticles Stimulate Adhesion and Migration of Monocytes in a PKC-Dependent Manner¿. [Oral Presentation], American Heart Association. ¿Platelet Microparticles Stimulate Adhesion and Migration of Monocytes in a PKC-Dependent Manner¿, Florida, USA , 01-JAN-97 - 01-JAN-97. [Details]
	(1997)	¿Platelet Microparticles Enhance Adhesive Interactions Between Monocytes and Endothelial Cells, O. Barry; (1997) ¿Platelet Microparticles Enhance Adhesive Interactions Between Monocytes and Endothelial Cells. [Oral Presentation], ¿Platelet Microparticles Enhance Adhesive Interactions Between Monocytes and Endothelial Cells, Biomedicine ¿97, Washington, DC, USA , 01-JAN-97 - 01-JAN-97. [Details]
	(1996)	Transcellular Signaling By Platelet Microparticles In Human Endothelial Cells and Platelets¿, o; (1996) Transcellular Signaling By Platelet Microparticles In Human Endothelial Cells and Platelets¿. [Oral Presentation], Transcellular Signaling By Platelet Microparticles In Human Endothelial Cells and Platelets¿, American Heart Association, New Orleans, USA , 01-JAN-96 - 01-JAN-96. [Details]

Committees

	Committee	Function	From / To
	Chair of Departmental Graduate Studies Committee		/

Education

Year	Institution	Qualification	Subject
1999	University Pennsylvania, Philadelphia, USA	PHD	*
2014	University College Cork	Masters in Teaching and Learning in Higher Education	Teaching & Learning in Higher Education - Third Level
1991	National University of Ireland, Cork	BSC (HONS)	*

Employment

Employer	Position	From / To
University College Cork	Lecturer Deparment of Pharmacology and Therapeutics	/
National University of Ireland, Cork	Post-Doctoral Research Fellow	01-DEC-99 / 01-AUG-02
University of Pennsylvania, Philadelphia, PA, USA	Post-Doctoral Research Fellow	01-MAR-99 / 01-NOV-99
University of Pennsylvania, Philadelphia, PA, USA	Pre-Doctoral Research Fellow	01-JUN-95 / 01-JAN-99

Languages

Language	Reading	Writing	Speaking
Gaeilge	Fluent	Fluent	Basic
English	Fluent	Fluent	Fluent
Spanish	Functional	Functional	Functional

Journal Activities

Journal	Role	To / From
Circulation	Referee	-
Cancer Research	Referee	-
International Journal Of Cancer	Referee	-

Teaching Interests

Undergraduate Teaching

Module Co-ordinator:
     PT2201 Principles of Dental Pharmacology
     PT3201 Dental Pharmacology
     PT2101/PT3005 Chemotherapy and Pharmacology of Inflammation
     RD2001 Periodontology

Contribute to:
     PT3001 Introduction to Pharmacology
     PT4011 Literature Research Project
     PT4010 Research Project (Intercalated BSc)
     PT4004 Research Project (Chemistry of Pharmaceutical Compounds)
     GEM1001 Fundamentals of Medicine I
     GEM1003 Fundamentals of Medicine III
     FM3003 Clinical Pharmacology

Postgraduate Teaching

PhD Scholars Programme In Cancer Biology: Rotation students in Year 1
                                                                  Mentor for Kathy Barriscale
                                                                  Mentor for William Byrne

Present Postgraduate Students: Carol O' Callaghan (2010-Present)
                                               Kinga Gebolys (co-supervised) (2007-Present)

Modules Taught

Term (ID))	Title	Link	Subject
2017	Principles of Dental Pharmacology	PT2201	Principles of Dental Pharmacology
2017	Dental Pharmacology	PT3201	Dental Pharmacology
2017	Chemotherapy and Pharmacology of Inflammation	PT3005	Chemotherapy and Pharmacology of Inflammation