Research Profile

Orla P Barry

Biography

Dr. Órla P. Barry graduated with an Honours Degree in Biochemistry in 1991 from University College Cork (UCC). This was followed by a Ph.D. at the University of Pennsylvania (UPENN), Philadelphia, USA on "Transcellular activation of platelet microparticles: A role for platelet microparticle arachidonic acid". A post-doctoral fellowship also at UPENN, involved investigating novel mechanisms of transcellular lipid metabolism and isoprostanes as indices of oxidant stress. Upon returning to Ireland at the end of 1999, she joined the Cork Cancer Research Centre as a Health Research Board (HRB) funded Post-Doctoral fellow. Dr. Barry was appointed Lecturer in Pharmacology, UCC, in 2002. She completed the Certificate in Teaching and Learning in 2012 followed by a Diploma in 2013 and graduated with an MA in Teaching and Learning, in Higher Education, in 2014 through UCC CIRTL (Centre for Integration of Research, Teaching and Learning).

Research Interests

Cell Signalling and Cancer 
Dr. Barry's research focuses on cancers with few treatment strategies and with no significant improvement in overall survival rate, namely, oesophageal and renal cancers. The paucity of therapeutic options, and their associated morbidity, has led to vital research for new therapeutic strategies. Research focuses on the study of different families of serine/threonine kinases that play key roles in signalling mechanisms following activation of seven-transmembrane and tyrosine-kinase receptors. In particular, our area of research focuses on the role of Paks, p38 MAPKs, and PKCs which exert a variety of cellular effects including changes in proliferation, malignant transformation, cell death and differentiation. Briefly, we have exploited the activation of PKC as a pro-apoptotic and anti-proliferative agent in oesophageal cancer. In addition we have re-introduced p38delta MAPK into different cancers which lack this isoform including oesophageal, renal, prostate, lung and liver which has profound effects on cell proliferation and apoptosis. Finally, we have identified different Pak isoforms which are pro-apoptotic in oesophageal and renal cancer. An important aspect of our research is to elucidate the signalling pathways underlying the apoptotic effect of these kinases using both pharmacological and molecular strategies. In addition, the use of athymic nude mice to study their effects is necessary to translate in vitro results to in vivo models of tumourigenesis in order to validate our experimental hypothesis in a physiological setting.  The identification of different kinase isoforms involved in cell proliferation and cell death in different types of cancer may have important therapeutic implications for the treatment of the disease.

Epigenetics and Cancer
Research on epigenetic gene silencing and on epigenetic drug-induced re-expression of tumour suppressor genes may influence future optimal treatment strategies and predict responses in oesophageal and renal cancer patients. Our research identified that epigenetic alterations are partly responsible for the promotion of tumourigenesis in oesophageal squamous cell carcinoma (OESCC). Given that epigenetic changes are reversible, we can investigate the utility of epigenetic modifiers - DNA methyltransferase inhibitors (DNMTi), histone deacetylase inhibitors (HDACi) and Bromodomain and Extra-Terminal motif inhibitors (BETi) as possible therapeutic strategies in the treatment of drug resistant OESCC.  Our work to-date has uniquely identified that some FDA cancer approved and investigational epigenetic modifiers (not all) can prevent the growth of drug resistant p38δ MAPK negative OESCC cell growth.  

Cardiovascular Research 
Cardiovascular research involved investigating the biological roles of platelet microparticles (PMP) formed from the plasma membrane and released into the extracellular space. Prior to my investigations their physiological role(s) remained ill-defined. My research highlighted a novel mechanism of transcellular lipid metabolism whereby platelet activation may be amplified or modulated by concentrated delivery of PMP arachidonic acid (AA) to adjacent platelets, endothelial cells, and monocytes. The demonstration that PMPs may modulate important aspects of endothelial and monocyte function provided a novel mechanism by which platelets may interact with such cells in human atherosclerosis and inflammation. In addition to my cellular and molecular studies of AA signalling and gene transcription, I have also studied the roles of isoprostanes (iPs) as indices of oxidant stress in patients with alcohol-induced hepatitis or alcohol-induced chronic liver disease. iPs are free radical-catalyzed products of AA formed in a COX-independent manner and have proved useful markers for lipid peroxidation.

Research Training
The aim within my laboratory is to train future investigators in an intellectually exciting and supportive work environment to carry out independent, high quality research. Our goal is to educate undergraduate, PhDs and post-doctoral fellows to a level where they have the research knowledge, understanding, critical analytical skills, and the know how to apply appropriate experimental design and state-of-the-art techniques to whatever emerging questions they are attempting to address. In summary, we concentrate on developing analytical, technical and interpersonal skills.
Our laboratory strives to train research scientists in cancer cell and molecular biology focusing on the pharmacological principles of how drugs work and why some are toxic. Our research is conducted at the molecular, cellular, organ, whole organism, and clinical levels. Thus, through individual research driven projects within the department in conjunction with national and international collaborative groups we provide abundant educational opportunities in the broader area of Pharmacology for both undergraduate and postgraduate students.

Teaching & Learning Research (SoTL/TFU/UDL/SDGs)

I have been involved in SoTL research since commencement of my lecturing post in AY0203. Since completing my MA in Higher Education (AY1314) I have been afforded the opportunity to research my teaching and learning (T&L) and in turn student learning and assessment using (i) a teaching for understanding (TFU) lens, (ii) the inclusion of a universal design for learning (UDL) and a scholarship of T&L (SoTL) approach and finally (iii) mappng my teaching to Sustainable Development Goals (SDGs) in particular SDG3 (Good Health and Well-Being), SDG4 (Quality Education), SGD5 (Gender Equality) and SDG12 (Responsible Consumption and Production). I apply the same stringent systematic investigation and methodologies to student learning and assessment as I would to my scientific research. This approach has led to T&L and assessment research collaborations with colleagues in CoMH and CIRTL with success in publishing our research findings and making our teaching and methods of student learning public.

Lab Members and Alumni
Ph.D. Students
Róisín M. Cassidy (2019-Present)
Chemosensitisation of oesophageal squamous cell carcinoma using epigenetic modifiers and cytotoxic drug polytherapy.

Carol O’ Callaghan (2010-2015)
Novel insights into the expression and function of p38d MAPK in oesophageal squamous cell carcinoma.

Monica Ambrose (2003-2008)
Investigation of Novel Therapeutic Targets for the Treatment of Oesophageal and Renal Cancer.

Ph.D. HRB Scholars Programme in Cancer Biology
Selina Lam (2012)
Analysis of p-p38δ MAPK activation, expression and subcellular localisation in oesophageal squamous cell carcinoma.

Ioanna Tzani (2012)
Generation of a constitutively active fusion construct to investigate the role of p-p38δ MAPK on the tumourigenicity of primary and metastatic oesophageal squamous carcinoma (OESCC).  

Kate Foley (2008)
Targeting p38δ MAPK in Metastatic Oesophageal Squamous cell carcinoma: a possible future therapeutic goal.

William Byrne (2008)
Generation of a series of fusion constructs to investigate the role(s) of p38δ and p-p38δ MAPK on the tumourigenicity of primary and metastatic oesophageal squamous carcinoma.


M.Sc. Students

Lea Herzel (2022)
An investigation of combining epigenetics and immunotherapies in oesophageal cancer treatment.

Ciara McCarthy (2021)
Ethanolamine: a cardioprotectant and chemosensitiser in oesophageal cancer.

Marie O’ Dea (2020)
Short-term cytotoxicity induced by epigenetic drugs in H9C2 cells.

Kyle Sadik (2019)
3D Tumour Spheroid Models for Epigenetic Drug Screening.

Rósín Cassidy (2018)
Epigenetic modulating compounds as potential therapeutic agents for treatment of oesophageal cancer.

M. Pharm. Students
Darragh Golden (2023)
Diagnosis, precision oncology and prognosis using liquid biopsies in oesophageal cancer.

Ailbhe Reilly (2022)
Combining epigenetics and immunotherapies in oesophageal cancer treatment: A match made in heaven?.

Internships

Mritunjay Mukherjee (2022)
Combining epigenetics and immunotherapy in the treatment of oesophageal cancer.

William O' Conor (2022)
Uncovering the mechanisms underlying DNMTi induced cardiotoxicity.

Alanna Denny (2021)
Epigenetic compounds as a therapeutic strategy in oesphageal cancer.

Kiran Pirambil (2019)
HDAC modulating compounds as potential therapeutic agents for treatment of p38d MAPK-negative oesophageal squamous cell carcinoma.

Vincent Caulier (2013)
Investigation of serine/threonine kinases in oesophageal carcinoma.

Intercalated BSc Students

Seamus Boyle (2011)
The anti-cancer effects of thyroid, renal and cardiac hormones.

David Antoine Lachmansingh (2006)
Investigation of the expression of p21-activated kinases 1 and 4 (Pak1, 4), serine/threonine kinases, in oesophageal carcinoma.  

Undergraduate FYPs
AY1314
Aoife Foley: Development of a methyl 2- (3,6-Diamino-9H-Xanthen-9-yl)Benzoate (Dihydrorhodamine 123) Assay To Measure The Production Of Reactive Oxygen Species Following Cytotoxic Anticancer Drug Treatment.

David J. Jones: An investigation of the anti-cancer effect(s) of docosahenaenoic acid derviatives Resolvin D1 and D2 in oesophageal cancer.

AY1213
Christine Roche: Does the presence or absence of p38δ MAPK affect the sensitivity of OESCC to cytotoxic drugs?.

AY1112
Aoife Hart: Analysis of a fusion plasmid pcDNA3-FLAG-MKK6 (E)-(Gly-Glu)5 -p38δ MAPK in Oesophageal Squamous Cell Carcinoma.

Aoibheann McNally: Characterization of p38 MAPK and MAPKK expression in pancreatic adenocarcinoma and squamous carcinoma cell lines.

AY1011
Jessica Anthony: Analysis of p38MAPK isoform subcellular localization in oesophageal cancer cells.

Patrick O Sullivan: Investigation of Angiotensin II as a possible future therapeutic target for the treatment of oesophageal cancer.

AY0910
Michelle Cotter: Targeting of p38 MAPK in prostate cancer.

AY0809
Claire Duggan: Investigation of the role of cyclooxygenase isoforms in Renal Cell Carcinoma apoptosis.

AY0607
Patrick Quille: Role of p38δ mitogen activated protein kinase as a regulator in oesophageal cancer proliferation.

Bernadette Queally: Role of p38δ mitogen activated protein kinase in conferring resistance and sensitivity in oesophageal cancer to various chemotherapeutic drugs.

Aisling Shanahan: Role of p38δ mitogen activated protein kinase in COX-2 activation in oesophageal cancer.

AY0506
Susan o’ Sullivan: Investigation of the role(s) of p38δ MAPK in cancer. 

AY0405 
Sinéad Milner: Investigation of the sonic hedgehog signalling pathway in oesophageal cancer.

Meadhbh Cronin:  Targeting oesophageal cancer with siRNA Paks.

Leanne Timpson:  Investigation of the differential role(s) of p38 MAPK isoforms in Renal Cell Carcinoma.

AY0304
Patricia Corkery:PKCs as critical mediators of cell growth and apoptosis in Renal Cell Carcinoma.

Tina-Marie Brennan: p38 MAPK as a critical mediator of cell growth and apoptosis in Renal Cell
Carcinoma.

Sarah Ormond: Role of Paks in Renal Cell Carcinoma.

AY0203
Cathal Lucey: Novel Approaches to the inhibition of renal carcinoma cell growth.

Cormac O' Keeffe: PKC and Oesophageal cancer.


















Research Grants

 ProjectFunding
Body
Start DateEnd DateAward
ChemosensitisationIrish Funded Research Non Exchequer01-OCT-1930-JUN-23€102,846.00
“Combining epigenetics and immunotherapy in the treatment of oesophageal cancer”.College of Medicine & Health18-JUL-2226-AUG-22€2,000.00
HEACOVID1901-APR-2131-MAR-23€6,000.00
“Making the disciplinary assessment literacy of Pharmacology explicit”.Other: Not Listed01-DEC-21
HDAC modulating compounds as potential therapeutic agents for treatment of p38 MAPK-negative oesophageal squamous cell carcinoma.College of Medicine & Health03-JUN-1912-JUL-19€2,000.00
Breakthrough Cancer Research: Epigenetic Modulating Compounds as Potential Therapeutic Agents for Treatment of Oesophagal CancerIrish Funded Research Non Exchequer01-OCT-1830-SEP-19€32,355.00
Targeting p38delta MAPK in oesophageal cancer, a possible future therapeutic goal?Health Research Board01-SEP-1031-AUG-14€184,003.00
Propagation of bone marrow micrometastases from oesophageal cancer.Science Foundation Ireland01-OCT-0830-SEP-11€46,500.00
Science Foundation Ireland Equipment GrantScience Foundation Ireland01-OCT-0730-SEP-08€48,595.00
[M.Sc. Medicine] {Barry Dr. Orla} NMiscellaneous Non Exchequer01-OCT-0330-SEP-05€33,000.00
PRTL3 with Biosciences Institute Cancer Grant for Capital Investment and Programmatic Funding.Higher Education Authority (HEA)01-OCT-0230-SEP-05€7,500.00
An investigation of serine/threonine kinases in oesophagogastric rib bone marrow micrometastatic cells.Other: Not Listed01-NOV-0231-DEC-03€10,000.00
“An Investigation of the in vitro and in vivo effects of PI 3-kinase inhibition, COX-2 inhibition, kinase-deficient Pak1 overexpression and adenoviral PKC isozyme delivery on oesophagogastric metastatic growth.Health Research Board01-OCT-0130-SEP-04€137,160.00

Publications

Book Chapters

 YearPublication
(2011)'Exploitation of aberrant signalling pathways as useful targets for renal clear cell carcinoma therapy'
Orla Patricia Barry and Carol O' Callaghan. (2011) 'Exploitation of aberrant signalling pathways as useful targets for renal clear cell carcinoma therapy' In: Renal Cancer. Croatia: InTECH. [Details]
(1997)'Urinary 8-Epi PGF2alpha:An Index Of Oxidant Stress In Vivo. In: Fibrinolysis and Protelysis'
M.P. Reilly, P. Barry, J.A. Lawson, and G.A.FitzGerald. (1997) 'Urinary 8-Epi PGF2alpha:An Index Of Oxidant Stress In Vivo. In: Fibrinolysis and Protelysis' In: Fibrinolysis and Proteolysis. *: *. [Details]
(1997)'Markers Of Platelet Activation And Oxidant Stress In Atherothrombotic Disease'
Garret A. FitzGerald, Jessica Tigges and Patricia Barry, and John A. Lawson. (1997) 'Markers Of Platelet Activation And Oxidant Stress In Atherothrombotic Disease' In: Thrombosis and Haemostasis. *: *. [Details]

Peer Reviewed Journals

 YearPublication
(2016)'Pregnancy-specific glycoprotein expression in normal gastrointestinal tract and in tumors detected with novel monoclonal antibodies'
Aileen Houston, John M. Williams, Tihana Lenac Rovis, Daniel K. Shanley, Ronan T. O'Riordan, Patrick A. Kiely, Melanie Ball, Orla P. Barry, Jacquie Kelly, Aine Fanning, John MacSharry, Ofer Mandelboim, Bernhard B. Singer, Stipan Jonjic & Tom Moore (2016) 'Pregnancy-specific glycoprotein expression in normal gastrointestinal tract and in tumors detected with novel monoclonal antibodies'. mAbs, 8 (2):405-413 [Details]
(2016)'Comparison of dental students' performances and perceptions in preclinical and clinical pharmacology in an Irish Dental School'
Barry OP, O'Sullivan E (2016) 'Comparison of dental students' performances and perceptions in preclinical and clinical pharmacology in an Irish Dental School'. European Journal of Dental Education, [Details]
(2015)'One size does not fit all in the assessment of pharmacology learning in a diverse multidisciplinary undergraduate student class'
Orla Patricia Barry, Eleanor O' Sullivan, Marian McCarthy (2015) 'One size does not fit all in the assessment of pharmacology learning in a diverse multidisciplinary undergraduate student class'. [DOI] [Details]
(2015)'Periodic review sessions contribute to student learning across the disciplines in Pharmacology'
Barry, O. P., O' Sullivan, E., and McCarthy, M. (2015) 'Periodic review sessions contribute to student learning across the disciplines in Pharmacology'. Journal of The Scholarship of Teaching and Learning, 15 (1):38-56 [Details]
(2015)'One size does not fit all in the assessment of pharmacology learning in a diverse multidisciplinary undergraduate student class'
Barry, O. P., O' Sullivan, E., and McCarthy, M. (2015) 'One size does not fit all in the assessment of pharmacology learning in a diverse multidisciplinary undergraduate student class'. International Journal of Basic and Clinical Pharmacology, [Details]
(2015)'Hypermethylation of MAPK13 Promoter in Oesophageal Squamous Cell Carcinoma Is Associated with Loss of p38δ MAPK Expression'
Carol O Callaghan, Liam J Fanning, Orla P Barry (2015) 'Hypermethylation of MAPK13 Promoter in Oesophageal Squamous Cell Carcinoma Is Associated with Loss of p38δ MAPK Expression'. Cancers (Basel)Cancers (Basel), :2124-2133 [DOI] [Full Text] [Details]
(2015)'p38δ MAPK phenotype: an indicator of chemotherapeutic response in oesophageal squamous cell carcinoma'
O' Callaghan C, Fanning LJ, Barry OP (2015) 'p38δ MAPK phenotype: an indicator of chemotherapeutic response in oesophageal squamous cell carcinoma'. Anti Cancer Drugs, [Details]
(2015)'Periodic review sessions contribute to student learning across the disciplines in pharmacology'
Barry, O.P., O'Sullivan, E. and McCarthy, M. (2015) 'Periodic review sessions contribute to student learning across the disciplines in pharmacology'. Journal of The Scholarship of Teaching and Learning, [Details]
(2014)'p38�� MAPK: Emerging Roles of a Neglected Isoform. International Journal of Cell Biology'
O' Callaghan C, Fanning LJ, Barry OP (2014) 'p38�� MAPK: Emerging Roles of a Neglected Isoform. International Journal of Cell Biology'. International Journal of Cell Biology, [Details]
(2013)'Loss of p38δ mitogen-activated protein kinase expression promotes oesophageal squamous cell carcinoma proliferation, migration and anchorage-independent growth'
O'Callagahan C, Fanning LJ, Houston A and Barry OP. (2013) 'Loss of p38δ mitogen-activated protein kinase expression promotes oesophageal squamous cell carcinoma proliferation, migration and anchorage-independent growth'. International Journal of Oncology, [Full Text] [Details]
(2007)'Modulation of p21-activated kinase 1 alters the behavior of renal cell carcinoma. Int J Cancer'
O'Sullivan GC, Tangney M, Casey G, Ambrose M, Houston A and Barry OP. ; (2007) 'Modulation of p21-activated kinase 1 alters the behavior of renal cell carcinoma. Int J Cancer'. International Journal of Cancer, [Details]
(2007)'Modulation of p21-activated kinase 1 alters the behavior of renal cell carcinoma'
O'Sullivan, G. C.,Tangney, M.,Casey, G.,Ambrose, M.,Houston, A.,Barry, O. P.; (2007) 'Modulation of p21-activated kinase 1 alters the behavior of renal cell carcinoma'. Int J Cancer, 121 (99):1930-401930   [Details]
(2006)'Induction of apoptosis in renal cell carcinoma by reactive oxygen species: involvement of extracellular signal-regulated kinase 1/2, p38delta/gamma, cyclooxygenase-2 down-regulation, and translocation of apoptosis-inducing factor'
Ambrose M, Ryan A, O¿ Sullivan GC, Dunne C, and Barry OP; (2006) 'Induction of apoptosis in renal cell carcinoma by reactive oxygen species: involvement of extracellular signal-regulated kinase 1/2, p38delta/gamma, cyclooxygenase-2 down-regulation, and translocation of apoptosis-inducing factor'. Mol Pharmacol, [Details]
(2001)'Effects of Vitamin E on Lipid Peroxidation in Healthy Persons'
Emma A. Meagher, Orla P. Barry, John A. Lawson, Joshua Rokach, and Garret A. FitzGerald; (2001) 'Effects of Vitamin E on Lipid Peroxidation in Healthy Persons'. JAMA : the journal of the American Medical Association, [Details]
(2001)'Protein Kinase C Isozymes, Novel Phorbol Ester Receptors and Cancer Chemotherapy'
Barry, O.P., and Kazanietz, M.G; (2001) 'Protein Kinase C Isozymes, Novel Phorbol Ester Receptors and Cancer Chemotherapy'. Curr. Pharm. Des, [Details]
(2001)'Constitutive ERK1/2 activation in esophagogastric rib bone marrow micrometastatic cells is MEK-independent'
Barry, O. P.,Mullan, B.,Sheehan, D.,Kazanietz, M. G.,Shanahan, F.,Collins, J. K.,O'Sullivan, G. C. (2001) 'Constitutive ERK1/2 activation in esophagogastric rib bone marrow micrometastatic cells is MEK-independent'. Journal of Biological Chemistry, 276 (181):15537-15546   [Details]
(1999)'Increased Oxidant Stress In Alcohol Liver Disease'
Emma A. Meagher, Orla P. Barry, Anne Burke, Michael R. Lucey, Joshua Rokach, and Garret A. FitzGerald; (1999) 'Increased Oxidant Stress In Alcohol Liver Disease'. J. Clin. Invest, [Details]
(1999)'Iron-Dependent Human Platelet Activation And Hydroxyl Radical Formation'
Domenico Pratico, Orla P. Barry, Andrea Ghiselli, Luigi Iuliano, Guiseppi Sabatino, Garret A. FitzGerald, and Francesco Violi. ; (1999) 'Iron-Dependent Human Platelet Activation And Hydroxyl Radical Formation'. Circulation, 99, [Details]
(1999)'Arachidonic Acid in Platelet Microparticles Upregulates Cyclooxygenase-2 Dependent Prostaglandin Formation Via a Protein Kinase C/Mitogen-Activated Protein Kinase-Dependent Pathway'
Orla P. Barry, Marcelo G. Kazanietz, Domenico Pratico, and Garret A. FitzGerald. ; (1999) 'Arachidonic Acid in Platelet Microparticles Upregulates Cyclooxygenase-2 Dependent Prostaglandin Formation Via a Protein Kinase C/Mitogen-Activated Protein Kinase-Dependent Pathway'. J. Biol. Chem, [Details]
(1999)'Alcohol-induced generation of lipid peroxidation products in humans'
Meagher, E.A., Barry, O.P., Burke, A., Lucey, M.R., Lawson, J.A., Rokach, J. and FitzGerald, G.A. (1999) 'Alcohol-induced generation of lipid peroxidation products in humans'. Journal of Clinical Investigation, [Details]
(1999)'Mechanisms Of Cellular Activation By Platelet Microparticles'
Orla P. Barry and Garret A. FitzGerald.; (1999) 'Mechanisms Of Cellular Activation By Platelet Microparticles'. Thrombosis and Haemostasis, [Details]
(1998)'IPF2 Alpha-1:An Index Of Lipid Peroxidation In Humans'
Domenico Pratico, ¶Orla P. Barry, John A. Lawson, Mustafa Adiyaman, Seong-Woo Huang, Subash P. Khanapure, Luigi Iuliano, Joshua Rokach, and Garret A. FitzGerald.; (1998) 'IPF2 Alpha-1:An Index Of Lipid Peroxidation In Humans'. Proceedings of the National Academy of Science, [Details]
(1998)'Modulation Of Monocyte-Endothelial Cell Interactions By Platelet Microparticles'
Orla P. Barry, Domenico Pratico, Rashmin C. Savani, and Garret A. FitzGerald. ; (1998) 'Modulation Of Monocyte-Endothelial Cell Interactions By Platelet Microparticles'. J. Clin. Invest, [Details]
(1998)'Effects of chronic therapy with vitamin E on lipid peroxidation in vivo in healthy humans'
Meagher, E.A., Barry, O.P., Bensinger, S., Rokach, J. and FitzGerald, G.A. (1998) 'Effects of chronic therapy with vitamin E on lipid peroxidation in vivo in healthy humans'. Journal of investigative medicine : the official publication of the American Federation for Clinical Research, [Details]
(1997)'Transcellular Activation Of Platelets And Endothelial Cells By Bioactive Lipids In Platelet Microparticles'
Orla P. Barry, Domenico Pratico, John A. Lawson, and Garret A. Fitzgerald. ; (1997) 'Transcellular Activation Of Platelets And Endothelial Cells By Bioactive Lipids In Platelet Microparticles'. J. Clin. Invest, [Details]
(1997)'Urinary excretion of IPF2 alpha-1 and 8-epi PGF(2 alpha): Specific analysis of distinct F-2 isoprostanes as noninvasive indices of oxidant stress in vivo'
Pratico, D., Barry, O.P., Lawson, J.A., Rokach, J, and FitzGerald, G.A. (1997) 'Urinary excretion of IPF2 alpha-1 and 8-epi PGF(2 alpha): Specific analysis of distinct F-2 isoprostanes as noninvasive indices of oxidant stress in vivo'. Circulation, [Details]
(1997)'Dietary Factors In Thrombosis And Haemostasis:Summary And Conclusions'
Garret A. FitzGerald and Patricia Barry; (1997) 'Dietary Factors In Thrombosis And Haemostasis:Summary And Conclusions'. Am. J. Clin. Nutr, [Details]
(1997)'Platelet microparticles stimulate adhesion and migration of monocytes in a PKC-dependent manner'
Barry, O.P., Pratico, D., Savani, R.C. and FitzGerald, G.A. (1997) 'Platelet microparticles stimulate adhesion and migration of monocytes in a PKC-dependent manner'. Circulation, [Details]
(1996)'Transcellular signaling by platelet microvesicles in human endothelial cells and platelets'
Barry, O.P., Pratico, D. and FitzGerald, G.A. (1996) 'Transcellular signaling by platelet microvesicles in human endothelial cells and platelets'. Circulation, [Details]

Conference Publications

 YearPublication
(2022)Irish Association of Pharmacology, 22nd Annual Meeting
Órla P Barry, Cathal McCarthy and Christian Waeber. (2022) Implementation of educational mind maps to promote integrated learning in basic and clinical pharmacology Irish Association of Pharmacology, 22nd Annual Meeting [Details]
(2022)Irish Association for Cancer Research, 58th Annual Conference
Róisín M. Cassidy, Tracey R. O’Donovan, Sharon L. McKenna, Órla P. Barry. (2022) Valproic acid enhances autophagy and sensitivity to 5-flurouracil but not oxaliplatin in oesophageal cancer cell lines Irish Association for Cancer Research, 58th Annual Conference [Details]
(2022)Irish Association of Pharmacology, 22nd Annual Meeting
Róisín Kelly-Laubscher, Caoimhe Flaherty and Órla P. Barry. (2022) Making the Disciplinary Assessment Literacy of Pharmacology Explicit Irish Association of Pharmacology, 22nd Annual Meeting [Details]
(2021)Irish Association of Pharmacologists, 21st Annual Meeting
Róisín M. Cassidy, Tracey R. O' Donovan, Sharon L. McKenna and Órla P. Barry (2021) Valproic acid can enhance autophagy and sensitivity to 5-fluorouracil but not to oxaliplatin in oesophageal cancer cell lines Irish Association of Pharmacologists, 21st Annual Meeting [Details]
(2021)Irish Association of Pharmacologists, 21st Annual Meeting
C. McCarthy, N. Uroz, R. Kelly-Laubscher, Ó.P. Barry (2021) Evaluation of cytotoxic activity and chemosensitisation of acute and chronic ethanolamine treatment on oesophageal squamous cell carcinoma Irish Association of Pharmacologists, 21st Annual Meeting [Details]
(2019)Irish Association of Pharmacologists, 20th Annual Meeting
Róisín Cassidy, Sharon McKenna and Órla P. Barry. (2019) HDAC inhibition chemosensitises oesophageal squamous celll carcinoma to 5-fluorouracil Irish Association of Pharmacologists, 20th Annual Meeting [Details]
(2013)104th Annual Meeting of the American-Association-for-Cancer-Research (AACR)
O' Callaghan, C., Fanning, L., Houston, A. and Barry, O.P. (2013) New paradigms for the modulatory actions of p38 delta MAPK restorative expression in esophageal squamous cancer cell growth, migration and response to chemotherapy: A possibel future therapeutic target 104th Annual Meeting of the American-Association-for-Cancer-Research (AACR) [Details]
(2006)Irish Association for Cancer Research
Ambrose M, O'Sullivan GC, Barry OP. (2006) Targeting Oesophageal Cancer with p38delta MAPK: a possible future therapeutic approach? Irish Association for Cancer Research [Details]
(2012)24th EORTC-NCI-AACR symposium on molecular targets and cancer therapeutics
O'Callaghan, C., Fanning, L., Houston, A. and Barry, O.P. (2012) Targeting p38 delta MAPK in oesophageal cancer: a possible future therapeutic goal? 24th EORTC-NCI-AACR symposium on molecular targets and cancer therapeutics [Details]
(2005)96th Annual Meeting of the American-Association-for-Cancer-Research
Ambrose, M., Ryan, A., Dunne, C., O' Sullivan, G. and Barry, O.P. (2005) Induction of apoptosis in 786-0 renal cell carcinoma by reactive oxygen species is ERK1/2-, p38 delta and gamma MAPK- and Pak-1-independent but JNK-independent 96th Annual Meeting of the American-Association-for-Cancer-Research [Details]
(1999)Gastroenterology and Haematology
Meagher, E.A., Barry, O.P., Lucey, M.R., Rokach, J. and FitzGerald, GA. (1999) Antioxidant modulation of free radical generation in cirrhosis Gastroenterology and Haematology [Details]
(1996)69th Scientific Sessions of the American Heart Association
Barry, O.P., Pratico, D. and FitzGerald, G.A. (1996) Transcellular signaling by platelet micovesicles in human endothelial cells and platelets 69th Scientific Sessions of the American Heart Association [Details]
(1997)Annual Meeting of the Association of American Physicians, the American Society for Clinical Investigation, and the American Federation for Medical Research: Biomedicine '97 Medical Research from Bench to Bedside
Barry, O.P., Pratico, D. and FitzGerald, G.A. (1997) Platelet mircoparticles enhance adhesive interactions between monocytes and endothelial cells Annual Meeting of the Association of American Physicians, the American Society for Clinical Investigation, and the American Federation for Medical Research: Biomedicine '97 Medical Research from Bench to Bedside [Details]
(1998)71st Scientific Sessions of the American Heart Association
Pratico, D., Luliano, L., Ferro, D., Barry, O.P., Valesini, G., Rokach, J., FitzGerald, G.A. and Violi, F. (1998) Ongoing thrombotic state in patients with antiphospholipid antibodies: a role for increased lipid peroxidation 71st Scientific Sessions of the American Heart Association [Details]
(1998)18th Annual Meeting of the Society of Perinatal Obstetricians
Regan, C., Barry, O.P., Lawson, J.A., Morgan, M.A. and FitzGerald, G.A. (1998) Isoprostane formation in normal pregnancy 18th Annual Meeting of the Society of Perinatal Obstetricians [Details]

Professional Activities

Honours and Awards

 YearTitleAwarding Body
2022VISTA Programme Awardee University College Cork
2008A finalist in the JMS Doctor Awards Oncology section. JMS Doctor Awards, Health Research Board & Eireann Healthcare Publications, Dublin.
2004Research on Innovative Forms of Teaching University College Cork
2002Overall winner of the JMS Doctor Awards JMS Doctor Awards, Health Research Board & Eireann Healthcare Publications, Dublin.
1998Trainee Investigator Award for Excellence in Scientific Research. Biomedicine, Washington DC, USA
1997Trainee Investigator Award for Excellence in Scientific Research. Biomedicine, Washington DC, USA

Professional Associations

 AssociationFunctionFrom / To
Irish Association of Pharmacologists Treasurer01-JAN-20 /
European Association for Clinical Pharmacology and Therapeutics Member30-NOV-16 /
International Union of Basic and Clinical Pharmacology Member30-NOV-16 /
Irish Association of Pharmacologists Member30-NOV-16 /
Irish Association for Cancer Research Member01-SEP-05 /
European Association for Cancer Research Member01-SEP-05 /
American Heart Association Member01-JAN-95 / 01-SEP-99

Conference Contributions

 YearPublication
(2022)Irish Association of Pharmacology, 22nd Annual Meeting,
Órla P Barry, Cathal McCarthy and Christian Waeber. (2022) Implementation of educational mind maps to promote integrated learning in basic and clinical pharmacology. [Poster Presentation], Irish Association of Pharmacology, 22nd Annual Meeting, Trinity College Dublin, Ireland . [Details]
(2022)Irish Association of Pharmacology, 22nd Annual Meeting,
Órla P. Barry, Cathal McCarthy and Christian Waeber. (2022) Implementation of educational Mind Maps to promote integrated learning in basic and clinical pharmacology. [Poster Presentation], Irish Association of Pharmacology, 22nd Annual Meeting, Dublin . [Details]
(2022)Irish Association for Cancer Research, 58th Annual Conference,
Róisín M. Cassidy, Tracey R. O' Donovan, Sharon L. McKenna and Órla P. Barry (2022) Valproic acid can enhance autophagy and sensitivity to 5-fluorouracil but not to oxaliplatin in oesophageal cancer cell lines. [Poster Presentation], Irish Association for Cancer Research, 58th Annual Conference, Galway . [Details]
(2022)Irish Association of Pharmacology, 22nd Annual Meeting,
Róisín Kelly-Laubscher, Caoimhe Flaherty and Órla P. Barry. (2022) Making the Disciplinary Assessment Literacy of Pharmacology Explicit. [Invited Lectures (Conference)], Irish Association of Pharmacology, 22nd Annual Meeting, Dublin . [Details]
(2021)Irish Association of Pharmacologists, 21st Annual Meeting,
C. McCarthy, N. Uroz, R. Kelly-Laubscher, Ó.P. Barry (2021) Evaluation of cytotoxic activity and chemosensitisation of acute and chronic ethanolamine treatment on oesophageal squamous cell carcinoma. [Poster Presentation], Irish Association of Pharmacologists, 21st Annual Meeting, Limerick . [Details]
(2021)Irish Association of Pharmacologists, 21st Annual Meeting,
Róisín M. Cassidy, Tracey R. O' Donovan, Sharon L. McKenna and Órla P. Barry (2021) Valproic acid can enhance autophagy and sensitivity to 5-fluorouracil but not to oxaliplatin in oesophageal cancer cell lines. [Oral Presentation], Irish Association of Pharmacologists, 21st Annual Meeting, Limerick . [Details]
(2019)Irish Association of Pharmacologists, 20th Annual Meeting,
Róisín M. Cassidy, Sharon L. McKenna and Órla P. Barry (2019) HDAC inhbition chemosensitises oesophageal squamous cell carcinoma to 5-fluorouracil. [Poster Presentation], Irish Association of Pharmacologists, 20th Annual Meeting, Belfast . [Details]
(2013)104th Annual Meeting of the American Association for Cancer Research,
O' Callaghan, C., Fanning L, Houston A. and Barry Ó.P. (2013) New paradigms for the modulatory actions of p38 delta MAPK restorative expression in esophageal squamous cancer cell growth, migration and response to chemotherapy: A possible future therapeutic target. [Poster Presentation], 104th Annual Meeting of the American Association for Cancer Research, Washington DC . [Details]
(2005)96th Annual Meeting of the American Association for Cancer Research,
Ambrose A, Ryan A, Dunne C, O' Sullivan G and Barry OP. (2005) Induction of apoptosis in 786-0 renal cell carcinoma by reactive oxygen species is ERK1/2-, p38 delta and gamma MAPK- and Pak-1-independent but JNK-independent. [Poster Presentation], 96th Annual Meeting of the American Association for Cancer Research, California . [Details]
(2015)EuroSoTL Bridging Boundaries Through the Scholarship of Teaching and Learning,
Orla P. Barry, Eleanor O'Sullivan, Marian McCarthy (2015) A retrospecitve eight year study of assessment type in evaluating performance of multidisciplinary students in pharmacology. [Poster Presentation], EuroSoTL Bridging Boundaries Through the Scholarship of Teaching and Learning, Univeristy College Cork . [Details]
(2008)PhD Scholars Cancer Research Programme,
Monica Ambrose, Gerald C. O' Sullivan and Órla P. Barry; (2008) Targeting Oesophageal Cancer with p38 delta MAPK: a possible future therapeutic target?. [Oral Presentation], PhD Scholars Cancer Research Programme, UCC , 01-JAN-08 - 01-JAN-08. [Details]
(2006)Cork Cancer Research Open Day,
O. Barry, G.C. O'Sullivan. (2006) Targeting oesophageal, renal and prostate cancer with p38 delta MAPK: a possible future therapeutic approach?. [Oral Presentation], Cork Cancer Research Open Day, Cork , 01-JAN-06 - 01-JAN-06. [Details]
(2004)Cork Cancer Research Open Day,,
Monica Ambrose, Gerald C. O' Sullivan and Órla P. Barry (2004) An investigation of the role(s) of kinases in oesophageal and renal carcinogenesis. [Oral Presentation], Cork Cancer Research Open Day,, Mercy University Hospital, Cork , 01-JAN-04 - 01-JAN-04. [Details]
(2004)National University of Ireland, Cork, Medical Research Open Day,
Monica Ambrose, Aideen Ryan, Colum Dunne, Gerald C. O' Sullivan, Órla P. Barry, (2004) Induction of apoptosis in 786-0 Renal Cell Carcinoma by Reactive Oxygen Species is ERK1/2, Pak-1 and p38 MAPK delta and -gamma-dependent but JNK-independent. [Oral Presentation], National University of Ireland, Cork, Medical Research Open Day, UCC , 01-JAN-04 - 01-JAN-04. [Details]
(2004)From Bench to Bedside Lecture series,
Monica Ambrose, Gerald C. O' Sullivan, Órla P. Barry, (2004) Targeting oesophageal cancer with siRNA Paks: a possible future therapeutic target?. [Oral Presentation], From Bench to Bedside Lecture series, ,Mercy Hospital Cork, Ireland , 01-JAN-04 - 01-JAN-04. [Details]
(2002)AACR American Association for Cancer Research, 93rd Annual Meeting,,
O. Barry; D. Pratico, G.A. FitzGerald (2002) Detection of Bone Marrow Micrometastasis Following Bone Neoadjuvant Chemoradiotherapy In Patients with Esophagogastric Malignancy. [Oral Presentation], AACR American Association for Cancer Research, 93rd Annual Meeting,, San Francisco, California , 01-JAN-02 - 01-JAN-02. [Details]
(2001)Cancer Seminar Series, UCC,
Orla P. Barry, Gerald C. O' Sullivan (2001) Characterisation and Manipulation of Mitogenic Signalling Cascades in Esophagogastric Micrometastatic Cancer. [Oral Presentation], Cancer Seminar Series, UCC, UCC , 01-JAN-01 - 01-JAN-01. [Details]
(2001)AACR American Association for Cancer Research, 92nd Annual Meeting,,
O.P. Barry, D. Pratico and Gerald C. O' Sullivan (2001) Constitutive ERK1/2 Activation In Esophagogastric Rib Bone Marrow Micrometastatic Cells is MEK-Independent. [Oral Presentation], AACR American Association for Cancer Research, 92nd Annual Meeting,, San Francisco, California , 01-JAN-01 - 01-JAN-01. [Details]
(2000)SYNCAN EU Program, 2000,
O. Barry, G.C. O'Sullivan (2000) Constitutive ERK1/2 Activation In Esophagogastric Rib Bone Marrow Micrometastatic Cells is MEK-Independent. [Oral Presentation], SYNCAN EU Program, 2000, Florence, Italy , 01-JAN-00 - 01-JAN-00. [Details]
(1998)Signal Transduction and Lipid Second Messener III, Keystone Symposia,
O. Barry, D. Pratico, G.A. FitzGerald (1998) Signal Transduction Pathways Induced by the Transcellular Delivery of Platelet Microparticle Arachidonic Acid. [Oral Presentation], Signal Transduction and Lipid Second Messener III, Keystone Symposia, Toas, New Mexico, USA , 01-JAN-98 - 01-JAN-98. [Details]
(1998)Signal Transduction Retreat,
O. Barry; D. Pratico, G.A. FitzGerald (1998) Arachidonic Acid in Platelet Microparticles Upregulates Cyclooxygenase-2 Dependent Prostaglandin Formation Via a PKC/MAPK-Dependent Pathway. [Oral Presentation], Signal Transduction Retreat, Philadelphia, USA , 01-JAN-98 - 01-JAN-98. [Details]
(1997)70th Session of the American Heart Association,
O. Barry, D. Pratico, G.A. FitzGerald (1997) Platelet Microparticles Stimulate Adhesion and Migration of Monocytes in a PKC-Dependent Manner. [Oral Presentation], 70th Session of the American Heart Association, Florida, USA , 01-JAN-97 - 01-JAN-97. [Details]
(1997)70th Session of the American Heart Association,
O. Barry, D. Pratico, G.A. FitzGerald (1997) Platelet Microparticles Stimulate Adhesion and Migration of Monocytes in a PKC-Dependent Manner. [Oral Presentation], 70th Session of the American Heart Association, Florida, USA , 01-JAN-97 - 01-JAN-97. [Details]
(1997)Biomedicine '97,
O. Barry, D. Pratico, G.A. FitzGerald (1997) Platelet Microparticles Enhance Adhesive Interactions Between Monocytes and Endothelial Cells. [Oral Presentation], Biomedicine '97, Washington, DC, USA , 01-JAN-97 - 01-JAN-97. [Details]
(1996)69th Session of the American Heart Association,
Orla P. Barry, Domenico Pratico and Garret A. FitzGerald (1996) Transcellular Signaling By Platelet Microparticles In Human Endothelial Cells and Platelets. [Oral Presentation], 69th Session of the American Heart Association, American Heart Association, New Orleans, USA , 01-JAN-96 - 01-JAN-96. [Details]

Committees

 CommitteeFunctionFrom / To
UCC Research and Postgraduate Affairs Committee Member2021 /
Irish Association of Pharmacologists Treasurer2020 /
UCC SoM Committee for staff recruitment (technical/lecturer/senior lecturer) Interviewer2007 /
Pharmacology and Therapeutics Biosafety Committee Radiation Safety Officer2002 / 2011
UCC Dental School Teaching and Learning Curriculum Pharmacology and Therapeutics representative2018 /
UCC Pharmacology and Therapeutics Graduate Studies Committee Chair2010 /

Employment

 EmployerPositionFrom / To
University College Cork Lecturer and PI, Department of Pharmacology and Therapeutics01-SEP-02 /
University College Cork Post-Doctoral Research Fellow01-DEC-99 / 01-AUG-02
University of Pennsylvania, Philadelphia, PA, USA Post-Doctoral Research Fellow01-MAR-99 / 01-NOV-99
University of Pennsylvania, Philadelphia, PA, USA Pre-Doctoral Research Fellow01-JUN-95 / 01-JAN-99
University of Pennsylvania, Philadelphia, PA, USA Research Scientist01-MAY-94 / 31-MAY-95
University College Dublin Research Scientist01-MAY-92 / 01-APR-94
Rowa Pharmaceuticals Research Scientist01-SEP-91 / 30-APR-92

Education

 YearInstitutionQualificationSubject
2014University College Cork Masters (1st Class Hons) in Teaching and Learning in Higher EducationTeaching & Learning in Higher Education - Third Level
2013University College Cork Postgrad Dip in Teaching & Learning in HEEducation: Teaching and Learning
2012University College Cork Postgrad Cert. in Teaching & Learning in HEEducation: Teaching and Learning
1999University Pennsylvania, Philadelphia, USA PHDPharmacology
1991University College Cork BSc (Hons)Biochemistry

Journal Activities

 JournalRoleTo / From
European Journal Of Dental Education Peer Reviewer21-MAR-22 -
European Journal Of Clinical Pharmacology Peer Reviewer27-MAY-19 -
Plos One Peer Reviewer06-SEP-16 -
Journal Of Pharmacy And Pharmacology Peer Reviewer01-AUG-14 -
Cancer Research Peer Reviewer08-APR-11 -
Circulation Peer Reviewer16-APR-10 -
International Journal Of Cancer Peer Reviewer15-APR-10 -

Outreach Activities

 Description

Interview with IrelandAM presenters (2002) resulting from top cancer research prize in the JMS Doctor Awards 2002.

Engaged in the organisation and participation in the Young Cancer Researchers Networking (YCRN) Translational Cancer Research Conference (2018).

I have provided DARE application assistance (2017).

Participation in dental care of children with special needs (2017).

Involved in the design, execution and student presentation of INTEL miniprojects (2016).

Languages

 LanguageReadingWritingSpeaking
Gaeilge FluentFluentBasic
English FluentFluentFluent
Spanish FunctionalFunctionalFunctional

Other Activities

 Description

I have been a Dental Council statutory examiner for non-EU Dental candidates in the discipline of Pharmacology since 2006.

Teaching Activities

Teaching Interests


Undergraduate Teaching:
Module Co-ordinator for 5 modules and lecture in:
     PT2201 Principles of Dental Pharmacology
     PT3201 Dental Pharmacology
     PT2101 Chemotherapy and Pharmacology of Inflammation
     PT3005 Chemotherapy and Pharmacology of Inflammation
     RD2001 Periodontology

Lecture in:
     PT2448 Cellular and Molecular Basis of Drug Action and Toxicity
     PT4021 Immunopharmacology and Chemotherapy
     MH3010 Structured Literature Project in Medical and Health Sciences
     MH4010 Research Project in Medical and Health Sciences
     
Postgraduate Lecturing: 
GM1001 Fundamentals of Medicine I
GM1002 Fundamentals of Medicine II
GM1003 Fundamentals of Medicine III
PF4016 Pharmacy Research Project
ML6002 Biological and Clinical Perspectives of Human Disease

Recent Postgraduates

 Graduation YearStudent NameInstitutionDegree TypeThesis Title
2019Kyle Sadik University College CorkMSc Health SciencesA 3D spheroid model for the study of dual cytotoxic-epigenetic drug therapy on oesophageal cancer cell growth.
2020Marie O' Dea University College CorkMSc Health SciencesShort-term cytotoxicity induced by epigenetic drugs in H9c2 cells.
2021Ciara McCarthy University College CorkMSc Health SciencesEthanolamine: a cardioprotectant and chemosensitizer in oesophageal cancer.
2008Monica Ambrose University College CorkPHDInvestigation of Novel Therapeutic Targets for the Treatment of Oesophageal and Renal Cancer.
2015Carol O'Callaghan University College CorkPHDNovel insights into the expression and function of p38delta MAPK in oesophageal squamous cell carcinoma.

Research Information

Internal Collaborators

 NameInstituteCountry
Dr. Sharon McKenna University College CorkIRELAND
Dr. Róisín Kelly-Laubscher University College CorkIRELAND
Dr. Kellie Dean University College CorkIRELAND

External Collaborators

 NameOrganisation / InstituteCountry
Professor Domenico Pratico Temple UniversityU.S.A.
Professor Marcelo G. Kazanietz University of PennsylvaniaU.S.A.

Contact details

  • Orla P Barry
    Lecturer, Dept. of Pharmacology and Therapeutics
  • o.barry@ucc.ie
  • Western Gateway Building,
    University College Cork.
  • 353-21-4205493

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Department of Pharmacology and Therapeutics

Cógaseolaíocht agus Teiripic

Room 2.36B, 2nd floor floor, T12XF62

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