Current Team Members:
Ms Samprikta Manna: PhD (Supervisor with Dr. Fergus McCarthy) Thesis topic: Axis of Placental Ageing in Adverse Pregnancy Outcomes;Telomeres and Mitochondria.
Colm McElwain: PhD (Supervisor with Dr. Fergus McCarthy) Thesis topic: Investigating mitochondrial dysfunction and meta-inflammation as a shared pathogenic network in pre-eclampsia and gestational diabetes mellitus
Aaron Barron: PhD (Supervisor with Prof. Gerard O' Keeffe) Investigating the effects of pre-eclampsia on the developing brain in order to develop new therapeutic approaches to improve brain health and function
Dr. Andrea Musumeci, Postdoctoral Researcher on the HRB COMRADES Study
Past Team Members:
Dr. Eszter Tuboly, Postdoctoral Researcher
Dr. Rachel Williamson PhD, Thesis topic: Characterisation of Mitochondrial Antioxidant Therapies for Pre-eclampsia.
Marta Giralt, Eramus Student
Nikoleta Nikou, Eramus Student
Chloe Ruchon, Erasmus Student
Diego Alberto Mendez Ceja, MSc. in Human Anatomy
Bakhit Ebad, Mustafa Abdalla, MSc. in Human Anatomy
I am module coordinator and contribute teaching on the Pharmacology modules on the the new BSc. Medical and Health Sciences
PT1020 Introduction to Pharmacology
PT2020 Introduction to Toxicology
PT2021 Molecular and Cellular Pharmacology
PT3020 Pharmacology of Disease
PT4021 Immunopharmacology & Chemotherapy
PT4024 Current Topics in Pharmacology
I also contribute teaching to the MH1050 Introduction to Translational Medicine, MH2020 Research Methods and MH3050 Advances in Translational Medicine modules in CK707.
Previously I have taught at both an undergraduate and postgraduate level in Dublin Institute of Technology and in University College Dublin. I have contributed to undergraduate teaching to medical students (third year pharmacology), nursing students (second year pharmacology) and science students (final year pharmacology) where I have delivered teaching modules ranging from vascular biology, renal pharmacology and immunopharmacology. I have contributed to the M.Sc. in Clinical Laboratory Science (DIT). In addition, I have been involved in designing and supervising laboratory research projects for final year Pharmacology students (UCD) and Biomedical Science students (DIT) since 2002.
Biography
Dr. Cathal McCarthy a Lecturer in Pharmacology and Therapeutics and is the Principal Investigator of the HRB-funded COMRADES Study: MitoChondrial DysfunctiOn and Metainflammation in PRe-eclampsiA and Gestational Diabetes Mellitus. I graduated with a B.Sc. Microbiology from University College Cork. I undertook my Ph.D studies in Vascular Biology in Dublin Institute of Technology, investigating the pathways modulating placental insufficiency in pre-eclampsia and IUGR. My postdoctoral studies in the School of Biomolecular and Biomedical Sciences in University College Dublin focused on the elucidation of novel atheroprotective networks mediating Conjugated Linoleic acid (CLA) induced regression of pre-established atherosclerosis using in vitro and in vivo models of disease. I joined INFANT in 2013 and the primary focus of my research is establishing the role of mitochondrial dysfunction in perinatal complications. In 2018, I joined the Department of Pharmacology and Therapeutics as Lecturer on the BSc. In Medical and Health Sciences degree programme. Cathal's research investigates the disruptive pathways causing pre-eclampsia and gestational diabetes mellitus and the development of novel therapeutics to effectively treat these pregnancy complications. Pre-eclampsia (PE) and gestational diabetes (GDM) are two common complications of pregnancy and affect 15% of first time mothers. Both conditions share common pathophysiological features including oxidative stress, inflammation, insulin resistance and widespread vascular endothelial dysfunction. Cathal’s research is interested in exploring therapeutic strategies of directly targeting mitochondria and determining their capacity to mediate the sophisticated signalling networks of the adipose-placenta axis in pre-eclampsia and gestational diabetes mellitus.Research Interests
Suspected pre-eclampsia (PE) is the most frequent clinical presentation to obstetric day-care units in Ireland and gestational diabetes mellitus (GDM) is the most common medical disorder of pregnancy in Irish women. Pre-eclampsia and gestational diabetes mellitus are intrinsically linked to elevated risks of poor maternal and perinatal outcomes with serious long-term sequelae for mother and baby. In fact gestational diabetes mellitus is a recognised independent risk factor for Pre-eclampsia. There is increasing evidence suggesting a common pathogenic link between pre-eclampsia and gestational diabetes mellitus. It has been proposed that this association may at least be in part due to insulin resistance. Pre-eclampsia and gestational diabetes mellitus also share additional pathomechanisms including oxidative stress and inflammation. Emerging data has shown that mitochondrial dysfunction acts as a pathogenic mediator of oxidative stress in perinatal complications. While my group’s work has established that exaggerated mitochondrial-ROS provoke inflammation and cause endothelial dysfunction in pre-eclampsia, there is additional evidence of elevated mitochondrial-ROS in gestational diabetes mellitus. Exciting new data has established a role for mitochondrial damage motifs in provoking inflammation. Furthermore, dysfunctional mitochondria and metabolic products have been shown to activate the NRLP3 inflammasome, a key regulatory nexus regulating obesity-associated insulin resistance. My group’s main research interests are: (a) Investigate the diagnostic significance of biomarkers of mitochondrial dysfunction in Pre-eclampsia. (b) Develop a novel effective therapy for Pre-eclampsia by directly targeting mitochondrial superoxide scavenging using the reduced uterine perfusion pressure (RUPP) rat model. (c) Define the metabolic, oxidative and inflammatory processes which mediate the immunopathology of Pre-eclampsia and Gestational Diabetes Mellitus (d) Investigate the therapeutic potential of mitochondrial-targeted antioxidants in ameliorating insulin resistance and metainflammation in Pre-eclampsia and Gestational Diabetes Mellitus.Current Team Members:
Ms Samprikta Manna: PhD (Supervisor with Dr. Fergus McCarthy) Thesis topic: Axis of Placental Ageing in Adverse Pregnancy Outcomes;Telomeres and Mitochondria.
Colm McElwain: PhD (Supervisor with Dr. Fergus McCarthy) Thesis topic: Investigating mitochondrial dysfunction and meta-inflammation as a shared pathogenic network in pre-eclampsia and gestational diabetes mellitus
Aaron Barron: PhD (Supervisor with Prof. Gerard O' Keeffe) Investigating the effects of pre-eclampsia on the developing brain in order to develop new therapeutic approaches to improve brain health and function
Dr. Andrea Musumeci, Postdoctoral Researcher on the HRB COMRADES Study
Past Team Members:
Dr. Eszter Tuboly, Postdoctoral Researcher
Dr. Rachel Williamson PhD, Thesis topic: Characterisation of Mitochondrial Antioxidant Therapies for Pre-eclampsia.
Marta Giralt, Eramus Student
Nikoleta Nikou, Eramus Student
Chloe Ruchon, Erasmus Student
Diego Alberto Mendez Ceja, MSc. in Human Anatomy
Bakhit Ebad, Mustafa Abdalla, MSc. in Human Anatomy
Research Grants
| Project | Funding Body | Start Date | End Date | Award | |
|---|---|---|---|---|---|
| Investigating Mitochondrial Dysfunction and Meta-Inflamation as a Shared Network in Pre-Eclampsia & Gestational Diabetes Mellitus. | Health Research Board | 01-JUN-18 | 31-DEC-23 | €789,143.00 | |
| ESR7 Axis of Placental Aging in Adverse Pregnancy Outcomes: Telomeres and Mitochondria | Horizon 2020 | 07-SEP-18 | 11-SEP-21 | €265,674.00 | |
| DIVINE Study; Dysfunctional MItochondria directly proVoke INflammation in Pre-Eclampsia | Health Research Board | 18-JAN-16 | 01-MAY-19 | €329,803.00 | |
| SFI Research Infrastructure 2015 (Category D: Opportunistic Funding); Sub-project of R17475; 16/RI/3404 | Science Foundation of Ireland | 01-OCT-16 | 30-JUN-19 | €36,822.00 | |
| Li-Cor Science Undergraduate Research Grant | Other: Not Listed | 01-AUG-17 | 01-AUG-18 | €19,135.00 | |
| UCC Strategic Repair Fund | Other: Not Listed | 01-APR-14 | 31-MAR-15 | €4,984.99 |
Publications
Peer Reviewed Journals
| Year | Publication | |
|---|---|---|
| (2023) | 'A proteomic profile of the healthy human placenta' Manna S;Scheel J;Noone A;McElwain CJ;Scaife C;Gupta S;English J;McCarthy C;McCarthy FP; (2023) 'A proteomic profile of the healthy human placenta'. Clinical Proteomics, 20 (1) [DOI] [Details] | |
| (2022) | 'Gene Co-expression Analysis of the Human Substantia Nigra Identifies ZNHIT1 as an SNCA Co-expressed Gene that Protects Against a-Synuclein-Induced Impairments in Neurite Growth and Mitochondrial Dysfunction in SH-SY5Y Cells' McCarthy E;Barron A;Morales-Prieto N;Mazzocchi M;McCarthy CM;Collins LM;Sullivan AM;O'Keeffe GW; (2022) 'Gene Co-expression Analysis of the Human Substantia Nigra Identifies ZNHIT1 as an SNCA Co-expressed Gene that Protects Against a-Synuclein-Induced Impairments in Neurite Growth and Mitochondrial Dysfunction in SH-SY5Y Cells'. Molecular Neurobiology, [DOI] [Details] | |
| (2022) | 'Computational Models on Pathological Redox Signalling Driven by Pregnancy: A Review' Samprikta Manna , Camino S. M. Ruano , Jana-Charlotte Hegenbarth, Daniel Vaiman, Shailendra Gupta, Fergus P. McCarthy , Céline Méhats , Cathal McCarthy, Clara Apicella and Julia Scheel (2022) 'Computational Models on Pathological Redox Signalling Driven by Pregnancy: A Review'. Antioxidants, 11 (585):585-595 [DOI] [Details] | |
| (2021) | 'Gestational Diabetes Mellitus and Maternal Immune Dysregulation: What We Know So Far' Colm J McElwain, Fergus P. McCarthy, Cathal M. McCarthy (2021) 'Gestational Diabetes Mellitus and Maternal Immune Dysregulation: What We Know So Far'. International Journal of Medical Sciences, 22 (8) [DOI] [Details] | |
| (2021) | 'NME1 Protects Against Neurotoxin-, a-Synuclein- and LRRK2-Induced Neurite Degeneration in Cell Models of Parkinson's Disease' Anantha J;Goulding SR;Tuboly E;O'Mahony AG;Moloney GM;Lomansey G;McCarthy CM;Collins LM;Sullivan AM;O'Keeffe GW; (2021) 'NME1 Protects Against Neurotoxin-, a-Synuclein- and LRRK2-Induced Neurite Degeneration in Cell Models of Parkinson's Disease'. Molecular Neurobiology, [DOI] [Details] | |
| (2021) | 'Preeclampsia and neurodevelopmental outcomes: Potential pathogenic roles for inflammation and oxidative stress?' Barron, Aaron; McCarthy, Cathal; O'Keeffe, Gerard (2021) 'Preeclampsia and neurodevelopmental outcomes: Potential pathogenic roles for inflammation and oxidative stress?'. Molecular Neurobiology, [DOI] [Full Text] [Details] | |
| (2021) | 'A comparative study of two immunoassays of maternal placental growth factor' Deirdre Hayes-Ryan, Keelin O'Donoghue, Cathal McCarthy, Ainhoa Totorika, Sarah Meaney (2021) 'A comparative study of two immunoassays of maternal placental growth factor'. Scandinavian Journal Of Clinical And Laboratory Investigationscandinavian Journal Of Clinical And Laboratory Investigation, [DOI] [Details] | |
| (2020) | 'microRNA-155 Is Decreased During Atherosclerosis Regression and Is Increased in Urinary Extracellular Vesicles During Atherosclerosis Progression' Fitzsimons, S;Oggero, S;Bruen, R;McCarthy, C;Strowitzki, MJ;Mahon, NG;Ryan, N;Brennan, EP;Barry, M;Perretti, M;Belton, O (2020) 'microRNA-155 Is Decreased During Atherosclerosis Regression and Is Increased in Urinary Extracellular Vesicles During Atherosclerosis Progression'. Frontiers In Immunology, 11 [DOI] [Details] | |
| (2020) | 'Mechanisms of Endothelial Dysfunction in Pre-eclampsia and Gestational Diabetes Mellitus: Windows Into Future Cardiometabolic Health?' Colm J McElwain, Eszter Tuboly, Fergus P. McCarthy, Cathal M. McCarthy (2020) 'Mechanisms of Endothelial Dysfunction in Pre-eclampsia and Gestational Diabetes Mellitus: Windows Into Future Cardiometabolic Health?'. Frontiers In Endocrinology, 11 (655) [DOI] [Details] | |
| (2020) | 'Investigating mitochondrial dysfunction in gestational diabetes mellitus and elucidating if BMI is a causative mediator' McElwain, Colm;McCarthy, Cathal M. (2020) 'Investigating mitochondrial dysfunction in gestational diabetes mellitus and elucidating if BMI is a causative mediator'. European Journal of Obstetrics & Gynecology and Reproductive Biology, 251 :60-65 [DOI] [Full Text] [Details] | |
| (2020) | 'L-(+)-Ergothioneine Significantly Improves the Clinical Characteristics of Preeclampsia in the Reduced Uterine Perfusion Pressure Rat Model' Rachel D. Williamson, Fergus P. McCarthy, Samprikta Manna, Emer Groarke, Douglas B. Kell, Louise C. Kenny, Cathal M. McCarthy (2020) 'L-(+)-Ergothioneine Significantly Improves the Clinical Characteristics of Preeclampsia in the Reduced Uterine Perfusion Pressure Rat Model'. Hypertension, 75 :561-568 [DOI] [Details] | |
| (2020) | 'The biology of ergothioneine, an antioxidant nutraceutical' Borodina I;Kenny LC;McCarthy CM;Paramasivan K;Pretorius E;Roberts TJ;van der Hoek SA;Kell DB; (2020) 'The biology of ergothioneine, an antioxidant nutraceutical'. Nutrition Research Reviews, [DOI] [Details] | |
| (2020) | 'Effect of L-Ergothioneine on the metabolic plasma profile of the RUPP rat model of pre-eclampsia' Morillon AC;Williamson RD;Baker PN;Kell DB;Kenny LC;English JA;McCarthy FP;McCarthy C; (2020) 'Effect of L-Ergothioneine on the metabolic plasma profile of the RUPP rat model of pre-eclampsia'. Plos One, 15 (3) [DOI] [Details] | |
| (2019) | '4-Hydroxychalcone Induces Cell Death via Oxidative Stress in MYCN-Amplified Human Neuroblastoma Cells' Alshangiti AM;Tuboly E;Hegarty SV;McCarthy CM;Sullivan AM;O'Keeffe GW; (2019) '4-Hydroxychalcone Induces Cell Death via Oxidative Stress in MYCN-Amplified Human Neuroblastoma Cells'. Oxidative Medicine and Cellular Longevity, 2019 [DOI] [Details] | |
| (2019) | 'Activation of a TLR9 mediated innate immune response in preeclampsia' Williamson RD;McCarthy FP;Kenny LC;McCarthy CM; (2019) 'Activation of a TLR9 mediated innate immune response in preeclampsia'. Scientific Reports, 9 (1) [DOI] [Details] | |
| (2019) | 'Placental Ageing in Adverse Pregnancy Outcomes: Telomere Shortening, Cell Senescence, and Mitochondrial Dysfunction' Manna S;McCarthy C;McCarthy FP; (2019) 'Placental Ageing in Adverse Pregnancy Outcomes: Telomere Shortening, Cell Senescence, and Mitochondrial Dysfunction'. Oxidative Medicine and Cellular Longevity, 2019 [DOI] [Details] | |
| (2018) | 'A perspective on pre-eclampsia and neurodevelopmental outcomes in the offspring: does maternal inflammation play a role?' Maher GM;McCarthy FP;McCarthy CM;Kenny LC;Kearney PM;Khashan AS;O'Keeffe GW; (2018) 'A perspective on pre-eclampsia and neurodevelopmental outcomes in the offspring: does maternal inflammation play a role?'. International Journal of Developmental Neuroscience, [DOI] [Details] | |
| (2018) | 'Biomarkers of glomerular dysfunction in pre-eclampsia - A systematic review' Kerley RN;McCarthy C; (2018) 'Biomarkers of glomerular dysfunction in pre-eclampsia - A systematic review'. Pregnancy Hypertension, [DOI] [Details] | |
| (2018) | 'Exploring the role of mitochondrial dysfunction in the pathophysiology of pre-eclampsia' Williamson R, McCarthy FP, Khashan A,Totorika A, Kenny LC, McCarthy CM (2018) 'Exploring the role of mitochondrial dysfunction in the pathophysiology of pre-eclampsia'. Pregnancy Hypertension, [Details] | |
| (2017) | 'Oxidative stress in pre-eclampsia; have we been looking in the wrong place?' 1. Williamson RD, McCarthy C, McCarthy FP, Kenny LC (2017) 'Oxidative stress in pre-eclampsia; have we been looking in the wrong place?'. Hypertension in pregnancy : official journal of the International Society for the Study of Hypertension in Pregnancy, [DOI] [Details] | |
| (2017) | 'The potential therapeutic effects of ergothioneine in pre-eclampsia' Kerley RN;McCarthy C;Kell DB;Kenny LC; (2017) 'The potential therapeutic effects of ergothioneine in pre-eclampsia'. Free Radical Biology & Medicine, 117 [DOI] [Details] | |
| (2016) | 'Magnesium sulphate prevents lipopolysaccharide-induced cell death in an in vitro model of the human placenta' Williamson, RD;McCarthy, C;Kenny, LC;O'Keeffe, GW (2016) 'Magnesium sulphate prevents lipopolysaccharide-induced cell death in an in vitro model of the human placenta'. Pregnancy Hypertension: An International Journal Of Women'S Cardiovascular Health, 6 :356-360 [DOI] [Details] | |
| (2016) | 'Therapeutically targeting mitochondrial redox signalling alleviates endothelial dysfunction in preeclampsia' McCarthy CM, Kenny LC (2016) 'Therapeutically targeting mitochondrial redox signalling alleviates endothelial dysfunction in preeclampsia'. Scientific Reports, 8 (6):32683-32694 [DOI] [Full Text] [Details] | |
| (2016) | 'Immunostimulatory role of mitochondrial DAMPs: alarming for pre-eclampsia?' McCarthy CM, Kenny LC (2016) 'Immunostimulatory role of mitochondrial DAMPs: alarming for pre-eclampsia?'. American journal of reproductive immunology (New York, N.Y. : 1989), doi: 10.1111/aji.12526. [Epub ahead of print] [Details] | |
| (2016) | 'Magnesium sulphate prevents lipopolysaccharide-induced cell death in an in vitro model of the human placenta' Williamson RD, McCarthy CM, Kenny LC, O'Keeffe G (2016) 'Magnesium sulphate prevents lipopolysaccharide-induced cell death in an in vitro model of the human placenta'. Hypertension in pregnancy : official journal of the International Society for the Study of Hypertension in Pregnancy, [Details] | |
| (2016) | 'Mitochondrial [dys]function; culprit in pre-eclampsia?' McCarthy CM, Kenny LC (2016) 'Mitochondrial [dys]function; culprit in pre-eclampsia?'. Clinical Science, 130 (14):1179-1184 [Full Text] [Details] | |
| (2015) | 'Dysregulated post-transcriptional control of COX-2 gene expression in gestational diabetic endothelial cells' Di Francesco L, Dovizio M, Trenti A, Marcantoni E, Moore A, O Gaora P, McCarthy C, Tacconelli S, Bruno A, Alberti S, Gizzo S, Nardelli GB, Orso G, Belton O, Trevisi L, Dixon DA, Patrignani P. (2015) 'Dysregulated post-transcriptional control of COX-2 gene expression in gestational diabetic endothelial cells'. British Journal of Pharmacology, 172 (18):4575-4587 [Details] | |
| (2013) | 'Macrophage PPAR gamma Co‐activator‐1 alpha participates in repressing foam cell formation and atherosclerosis in response to conjugated linoleic acid' McCarthy C, Lieggi NT, Barry D, Mooney D, de Gaetano M, James WG, McClelland S, Barry MC, Escoubet-Lozach L, Li AC, Glass CK, Fitzgerald DJ, Belton O. (2013) 'Macrophage PPAR gamma Co‐activator‐1 alpha participates in repressing foam cell formation and atherosclerosis in response to conjugated linoleic acid'. The Embo Journal, 5 (9):1443-1457 [Details] | |
| (2013) | 'IL-10 mediates the immunoregulatory response in conjugated linoleic acid-induced regression of atherosclerosis' McCarthy, Cathal Duffy, Michelle Mooney, Declan James, William Fitzgerald, Desmond J Griffin, Matthew D Belton, Orina (2013) 'IL-10 mediates the immunoregulatory response in conjugated linoleic acid-induced regression of atherosclerosis'. The Faseb Journal, 27 (2):499-510 [Details] | |
| (2012) | 'Effects of conjugated linoleic acid isomers on monocyte, macrophage and foam cell phenotype in atherosclerosis' Mooney, Declan McCarthy, Cathal Belton, Orina (2012) 'Effects of conjugated linoleic acid isomers on monocyte, macrophage and foam cell phenotype in atherosclerosis'. Prostaglandins, Leukotrienes, and Essential Fatty Acids, 98 (3):56-62 [Details] | |
| (2011) | 'Standardization of models and methods used to assess nanoparticles in cardiovascular applications' Fitzgerald, Kathleen T and Holladay, Carolyn A and McCarthy, Cathal and Power, Karen A and Pandit, Abhay and Gallagher, William M (2011) 'Standardization of models and methods used to assess nanoparticles in cardiovascular applications'. Small, 7 (6):705-717 [Details] | |
| (2011) | 'Mesenchymal stem cell inhibition of T‐helper 17 cell‐differentiation is triggered by cell–cell contact and mediated by prostaglandin E2 via the EP4 receptor' Duffy, Michelle M Pindjakova, Jana Hanley, Shirley A McCarthy, Cathal Weidhofer, Gudrun A Sweeney, Eva M English, Karen Shaw, Georgina Murphy, J Mary Barry, Frank P, Mahon BP, Belton O, Ceredig R, Griffin MD. (2011) 'Mesenchymal stem cell inhibition of T‐helper 17 cell‐differentiation is triggered by cell–cell contact and mediated by prostaglandin E2 via the EP4 receptor'. European Journal of Immunology, 41 (10):2840-2851 [Details] | |
| (2010) | 'SorLA modulates atheroprotective properties of CLA by regulating monocyte migration' McCarthy, Cathal and O’Gaora, Peadar and James, William G and McClelland, Sarah and Fitzgerald, Desmond J and Belton, Orina and de Gaetano, Monica (2010) 'SorLA modulates atheroprotective properties of CLA by regulating monocyte migration'. Atherosclerosis, 213 (2):400-407 [Details] | |
| (2010) | 'Conjugated linoleic acid suppresses the migratory and inflammatory phenotype of the monocyte/macrophage cel' McClelland, Sarah Cox, Clare O’Connor, Roisin de Gaetano, Monica McCarthy, Cathal Cryan, Lorna Fitzgerald, Des Belton, Orina (2010) 'Conjugated linoleic acid suppresses the migratory and inflammatory phenotype of the monocyte/macrophage cel'. Atherosclerosis, 211 (1):96-102 [Details] | |
| (2007) | 'Altered gene expression patterns in intrauterine growth restriction: potential role of hypoxia' McCarthy, Cathal Cotter, Finbarr E McElwaine, Suzanne Twomey, Anne Mooney, Eoghan E Ryan, Fergus Vaughan, Joseph (2007) 'Altered gene expression patterns in intrauterine growth restriction: potential role of hypoxia'. American Journal of Obstetrics and Gynecology, 196 (1):70. e1-70. e6 [Details] | |
| (2004) | 'Increased frequency of the MTHFR A1298C mutation in an Irish population' McCarthy C, Ryan F, Vaughan J (2004) 'Increased frequency of the MTHFR A1298C mutation in an Irish population'. Clinical chemistry, 50 (12):2462-2463 [DOI] [Details] |
Conference Publications
| Year | Publication | |
|---|---|---|
| (2017) | Blair Bell Research Society: Annual Academic Meeting Rachel Williamson, Cathal McCarthy, Fergus P McCarthy, Ali Khashan, Louise C. Kenny (2017) Exploring the role of mitochondrial dysfunction in the aetiology of pre-eclampsia Blair Bell Research Society: Annual Academic Meeting [Details] | |
| (2017) | International Socierty for the Study of Hypertension in Pregnancy Rachel Williamson, Cathal McCarthy, Fergus P. McCarthy, Ali Khashan, Louise C Kenny (2017) OP 15 Investigating the role of mitochondrial dysfunction as a biomarker of pre-eclampsia International Socierty for the Study of Hypertension in Pregnancy Volume 9, , pp.15-15 [Details] | |
| (2016) | 20th World Congress of the International Society for the Study of Hypertension in Pregnancy (ISSHP) McCarthy CM, Kenny LC (2016) MITOCHONDRIAL SUPEROXIDE SCAVENGERS MEDIATE ENDOTHELIAL DYSFUNCTION IN PRE-ECLAMPSIA 20th World Congress of the International Society for the Study of Hypertension in Pregnancy (ISSHP) Sau Paulo, , 23-OCT-16 - 26-OCT-16 [DOI] [Details] | |
| (2015) | Pregnancy Hypertension McCarthy C, Kenny LC (2015) Elucidation of a role for mitochondrial superoxide in modulating plasma mediator-induced endothelial dysfunction Pregnancy Hypertension [Details] | |
| (2014) | REPRODUCTIVE SCIENCES McCarthy, Cathal M Delany, Aoife McCarthy, Fergus P Walsh, Sarah K Kenny, Louise C (2014) PGC-1 alpha Is a Negative Regulator of Vascular Oxidative Stress by Co-Ordinating Adaptive Changes in the Mitochondrion during Pre-Eclampsia REPRODUCTIVE SCIENCES [Details] | |
| (2012) | CIRCULATION RESEARCH McCarthy, Cathal Mooney, Declan de Gaetano, Monica James, William Fitzgerald, Desmond J Belton, Orina (2012) Activation of the Nuclear Receptor Coactivator PGC-1 alpha Mediates an Atheroprotective Effect CIRCULATION RESEARCH Vol.111 Issue 4, [Details] | |
| (2012) | CIRCULATION RESEARCH McCarthy, Cathal Duffy, Michelle Mooney, Declan James, William Fitzgerald, Desmond J Griffin, Matthew D Belton, Orina (2012) Il-10 Regulates the Immunoregulatory Response in the Regression of Atherosclerosis CIRCULATION RESEARCH [Details] | |
| (2011) | BLOOD Salunkhe, Vishal A and Macaulay, Iain and Nuernberg, Sylvia and McCarthy, Cathal and Ouwehand, Willem Hendrik and Fitzgerald, Desmond J and Maguire, Patricia (2011) The MEIS1 Interactome in Megakaryocytes Reveals a Role in Cell Cycle Regulation BLOOD , pp.1449-1450 [Details] | |
| (2010) | ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY McCarthy, Cathal Mooney, Declan Fitzgerald, Desmond Belton, Orina (2010) Identification of a PGC1 alpha Modulated Network Induced by Conjugated Linoleic Acid in the Regression of Atherosclerosis ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY Vol. 30 issue 11, , pp.E206-E206 [Details] | |
| (2009) | Atherosclerosis Supplements McCarthy, C Cox, C Belton, O (2009) P235 CONJUGATED LINOLEIC ACID REDUCES EXPRESSION OF MIGRATORY REGULATOR SORL1 IN THE VASCULATURE Atherosclerosis Supplements Vol.10 Issue 2, [Details] | |
| (2005) | THROMBOSIS RESEARCH McCarthy, C Ryan, F Murphy, K Vaughan, J (2005) Development of a multiplex ARMS PCR for detection of thrombosis related mutations THROMBOSIS RESEARCH , pp.129-130 [Details] | |
| (2005) | THROMBOSIS RESEARCH McCarthy, C Ryan, F Mooney, E Vaughan, J (2005) Apoptosis and proliferation in IUGR placentae THROMBOSIS RESEARCH Vol 115, , pp.130-130 [Details] |
Thesis/Dissertation
| Year | Publication | |
|---|---|---|
| (2005) | Biomarkers for placental abnormality. Cathal McCarthy (2005) Biomarkers for placental abnormality. Thesis/Dissertation [Details] |
Reviews
| Year | Publication | |
|---|---|---|
| (2019) | Placental Ageing in Adverse Pregnancy Outcomes: Telomere Shortening, Cell Senescence, and Mitochondrial Dysfunction. Manna, S;McCarthy, C;McCarthy, FP (2019) Placental Ageing in Adverse Pregnancy Outcomes: Telomere Shortening, Cell Senescence, and Mitochondrial Dysfunction. LONDON: Reviews [DOI] [Details] | |
| (2017) | Oxidative stress in pre-eclampsia; have we been looking in the wrong place?. Williamson, RD;McCarthy, C;McCarthy, FP;Kenny, LC (2017) Oxidative stress in pre-eclampsia; have we been looking in the wrong place?. OXFORD: Reviews [DOI] [Details] |
Professional Activities
Professional Associations
| Association | Function | From / To | |
|---|---|---|---|
| British Pharmacology Society | Member | 28-DEC-20 / | |
| International Society for the Study of Hypertension in Pregnancy | Member | 03-AUG-15 / |
Employment
| Employer | Position | From / To | |
|---|---|---|---|
| University College Cork | Lecturer in Pharmacology and Therapeutics | 01-AUG-18 / | |
| INFANT Centre, University College Cork | HRB Principal Investigator | 01-AUG-17 / 30-JUN-22 | |
| INFANT Centre, University College Cork | Research Fellow | 01-FEB-16 / 31-JUL-17 | |
| INFANT Centre, University College Cork | Senior Postdoctoral Scientist | 01-OCT-13 / 31-JAN-16 | |
| University College Cork | Research Associate | 01-SEP-12 / 31-AUG-13 | |
| School of Biomolecular and Biomedical Sciences, University College Dublin | Research Manager | 01-SEP-11 / 31-AUG-12 | |
| School of Biomedical and Biomolecular Science, UCD | Senior Postdoctoral Scientist | 01-SEP-09 / 31-AUG-11 | |
| School of Biomedical and Biomolecular Science, UCD | Postdoctoral Scientist | 01-SEP-06 / 31-AUG-09 | |
| School of Biological Sciences, DIT, Kevin St. Dublin | Research Scientist | 01-MAR-06 / 31-MAY-06 |
Conference Contributions
| Year | Publication | |
|---|---|---|
| (2016) | Society of Reproductive Investigation, McCarthy CM, Kenny LC (2016) Mitochondrial-targeted antioxidants mediate endothelial dysfunction in pre-eclampsia. [Poster Presentation], Society of Reproductive Investigation, Montreal . [Details] | |
| (2016) | World Congress of the International Society for the Study of Hypertension in Pregnancy (ISSHP), Cathal McCarthy, Louise Kenny (2016) MITOCHONDRIAL SUPEROXIDE SCAVENGERS MEDIATE ENDOTHELIAL DYSFUNCTION IN PRE-ECLAMPSIA. [Invited Lectures (Conference)], World Congress of the International Society for the Study of Hypertension in Pregnancy (ISSHP), Sau Paulo, Brazil , 23-OCT-16 - 26-OCT-16. [Details] | |
| (2015) | RCOG annual academic meeting 2015, Williamson R, McCarthy C, O'Keeffe GW, Kenny LC. (2015) To assess the molecular and cellular mechanisms regulated by magnesium sulphate in regulating placental function using in vitro models of the human placenta. [Poster Presentation], RCOG annual academic meeting 2015, London, UK . [Details] | |
| (2015) | ISSHP 2014, McCarthy C, Kenny LC (2015) International Society for the study of Hypertension in Pregnancy. [Oral Presentation], ISSHP 2014, New Orleans , 05-JAN-15. [Details] | |
| (2015) | Society for Reproductive investigation 2015, Williamson R, McCarthy C, Kenny LC, O'Keeffe GW. (2015) Assessing the molecular and cellular mechanisms regulated by Magnesium Sulphate in an in vitro model of the human placenta. [Poster Presentation], Society for Reproductive investigation 2015, San Francisco, USA . [Details] | |
| (2014) | Young Life Scientists Conference, Williamson R, McCarthy C, O’Keeffe GW, Kenny LC (2014) Molecular and cellular mechanisms of magnesium sulphate in regulating placental function studied using in vitro models of the human placenta. [Poster Presentation], Young Life Scientists Conference, TCD, Dublin , 01-MAR-14 - 01-MAR-14. [Details] |
Committees
| Committee | Function | From / To | |
|---|---|---|---|
| INFANT Research Seminar Series | Organiser | 2014 / 2018 | |
| Member UCD Laboratory Organising Committee, Conway Institute | Member | 2009 / 2012 |
Honours and Awards
| Year | Title | Awarding Body | |
|---|---|---|---|
| 2014 | ISSHP Travel Award | International Society for the Study of Hypertension in Pregnancy | |
| 2014 | Medical Research Supplement Award | UCC Medicine | |
| 2011 | Outstanding Abstracts Presented at American Heart Association's Specialty Conferences | American Heart Association | |
| 2009 | Young Investigator Award Finalist | International Symposium on Atherosclerosis |
Education
| Year | Institution | Qualification | Subject | |
|---|---|---|---|---|
| 2006 | Dublin Institute of Technology | PhD | Molecular Biology | |
| 2001 | UCC | BSC - MICROBIOLOGY - UCC | Microbiology |
Languages
| Language | Reading | Writing | Speaking | |
|---|---|---|---|---|
| English |
Journal Activities
| Journal | Role | To / From | |
|---|---|---|---|
| Journal Of Nutritional Biochemistry | Referee | 01-FEB-10 - 10-SEP-10 | |
| Molecular And Cellular Endocrinology | Referee | 01-JUN-16 - | |
| Clinical Science | Referee | 02-FEB-16 - | |
| Hypertension | Referee | 01-DEC-15 - | |
| Plos One | Referee | 02-MAR-11 - 01-OCT-11 | |
| Cell And Tissue Research | Referee | 14-JAN-15 - |
Other Activities
| Description | |
|---|---|
Postgraduate Diploma in Teaching and Learning in Higher Education 2017/2018 | |
Postgraduate Certificate in Teaching and Learning in Higher Education 2016/2017 | |
IMI Aspiring Leaders Programme 2019 | |
Completed Professional Skills for Research Leaders online programme in 2015. Received Certificate Institute of Leadership and Management |
Teaching Activities
Teaching Interests
Currently, I am Year 1 Coordinator for the new BSc. programme in Medical and Health Sciences CK707 (https://www.ucc.ie/en/ck707/).I am module coordinator and contribute teaching on the Pharmacology modules on the the new BSc. Medical and Health Sciences
PT1020 Introduction to Pharmacology
PT2020 Introduction to Toxicology
PT2021 Molecular and Cellular Pharmacology
PT3020 Pharmacology of Disease
PT4021 Immunopharmacology & Chemotherapy
PT4024 Current Topics in Pharmacology
I also contribute teaching to the MH1050 Introduction to Translational Medicine, MH2020 Research Methods and MH3050 Advances in Translational Medicine modules in CK707.
Previously I have taught at both an undergraduate and postgraduate level in Dublin Institute of Technology and in University College Dublin. I have contributed to undergraduate teaching to medical students (third year pharmacology), nursing students (second year pharmacology) and science students (final year pharmacology) where I have delivered teaching modules ranging from vascular biology, renal pharmacology and immunopharmacology. I have contributed to the M.Sc. in Clinical Laboratory Science (DIT). In addition, I have been involved in designing and supervising laboratory research projects for final year Pharmacology students (UCD) and Biomedical Science students (DIT) since 2002.
Recent Postgraduates
| Graduation Year | Student Name | Institution | Degree Type | Thesis Title | |
|---|---|---|---|---|---|
| 2023 | Aaron Barron | University College Cork | PHD | Investigating the effects of pre-eclampsia on the developing brain in order to develop new therapeutic approaches to improve brain health and function | |
| 2022 | Colm McElwain | University College Cork | PHD | ||
| 2021 | Samprikta Manna | University College Cork | PHD | ||
| 2019 | Rachel Williamson | University College Cork | PHD | ||
| 2013 | Monica deGaetano | University College Dublin | PhD | ||
| 2012 | Declan Mooney | University College Dublin | PhD |
Research Information
Internal Collaborators
| Name | Institute | Country | |
|---|---|---|---|
| Professor Gerard O'Keeffe | Department of Anatomy and Neuroscience, UCC | IRELAND | |
| Dr. Fergus McCarthy | Department of Obstetrics and Gynaecology, UCC | IRELAND | |
| Dr. Ali Khashan | University College Cork | IRELAND |
External Collaborators
| Name | Organisation / Institute | Country | |
|---|---|---|---|
| Prof Louise Kenny | University of Liverpool | UNITED KINGDOM | |
| Professor Douglas B Kell | Research Chair in Bioanalytical Science, School of Chemistry, and Manchester Institute of Biotechnology, The University of Manchester, . | UNITED KINGDOM | |
| Dr. Orina Belton | University College Dublin | IRELAND | |
| Professor Joey Granger | Professor of Physiology and Medicine, University of Mississippi Medical Center | U.S.A. | |
| Dr. Fionnuala Ni Ainle | University College Dublin | IRELAND | |
| Professor Matt Griffin | National University of Ireland, Galway | IRELAND |
Contact details
- Cathal McCarthy
Lecturer in Pharmacology and Therapeutics - cmccarthy@ucc.ie
- Room 2.48
Dept of Pharmacology and Therapeutics
Western Gateway Building, Western Road
Cork - 0214205970