Biography
In 2000, Prof Walther became Research Assistant Professor and Head of the research group on Molecular Cardiology at the Benjamin Franklin University Hospital, Berlin, Germany. Four years later, he was appointed to the Associate Professorship at the Department of Pharmacology at the Erasmus Medical Centre in Rotterdam, the Netherlands, where he was also Head of Molecular Pharmacology. In 2007, he was appointed to the Chair of Biomedical Sciences and held the full professorship of Cardiovascular Physiology at the Hull, York Medical School, University of Hull, UK. In August 2009, he was recruited by the University of Giessen, Germany to establish the Department of Experimental Cardiology and held the commission for the Excellence Cluster Cardio-Pulmonary System (ECCPS) for the Department until July 2011. In 2009 and 2010 he was appointed to two Visiting Professorships at the University of Leipzig, Germany and at the University of Ipatinga, Brazil, respectively.
Research Interests
The international orientation of Prof. Thomas Walther’s research has increasingly gained in importance over the past years, especially in the fields of programs that combine basic and translational research in order to improve the prediction and treatment of cardiovascular diseases. He is consequently following the strategy of molecular investigation, followed by evaluation in animal models, and finally establishing proof of concept in humans aiming to find new therapeutic strategies.
Using these complex approaches, he is investigating the role of three different peptide systems (renin-angiotensin system, kallikrein-kinin system, natriuretic peptide system) in the aetiology of different diseases, mainly focused on cardiovascular pathophysiology in end-organs such as the brain or heart. Since identifying intense interactions of these systems, he is interested in finding out how an imbalance of cross-talk can influence the development of heart failure and vascular diseases. These investigations are especially focused on altered gene regulation, modified receptor/receptor interaction, and receptor mediated intracellular signalling.
Professor Walther’s main aims are to continue improving the understanding of the roles of these important signalling systems in cardiovascular disease and to identify pharmacological targets for new drugs. The ultimate aim is to improve patient outcome from cardiovascular conditions. Over the last ten years this research has resulted in over 110 papers published in peer reviewed scientific journals.
Publications
Peer Reviewed Journals
| Year | Publication | |
|---|---|---|
| (2019) | 'Age-dependent differences in pulmonary host responses in ARDS: a prospective observational cohort study' Schouten, LR;van Kaam, AH;Kohse, F;Veltkamp, F;Bos, LD;de Beer, FM;van Hooijdonk, RT;Horn, J;Straat, M;Witteveen, E;Glas, GJ;Wieske, L;van Vught, LA;Wiewel, MA;Ngelse, SAI;Cortjens, B;van Woensel, JB;Bos, AP;Walther, T;Schultz, MJ;Wosten-van Asperenl, RM;Hoogendijk, AJ;Huson, MA;van der Poll, T;Scicluna, B;Bonten, MJ;Cremer, OL;Frencken, JF;van de Groep, K;Klouwenberg, PMK;Koster-Brouwer, ME;Ong, DS;Verboom, DM (2019) 'Age-dependent differences in pulmonary host responses in ARDS: a prospective observational cohort study'. Annals Of Intensive Care, 9 [DOI] [Details] | |
| (2018) | 'Neprilysin degrades murine Amyloid-beta (A beta) more efficiently than human A beta: Further implication for species-specific amyloid accumulation' Becker, M;Moore, A;Naughton, M;Boland, B;Siems, WE;Walther, T (2018) 'Neprilysin degrades murine Amyloid-beta (A beta) more efficiently than human A beta: Further implication for species-specific amyloid accumulation'. Neuroscience Letters, 686 :74-79 [DOI] [Details] | |
| (2018) | 'Expert consensus document on the management of hyperkalaemia in patients with cardiovascular disease treated with renin angiotensin aldosterone system inhibitors: coordinated by the Working Group on Cardiovascular Pharmacotherapy of the European Society of Cardiology' Rosano, GMC;Tamargo, J;Kjeldsen, KP;Lainscak, M;Agewall, S;Anker, SD;Ceconi, C;Coats, AJS;Drexel, H;Filippatos, G;Kaski, JC;Lund, L;Niessner, A;Ponikowski, P;Savarese, G;Schmidt, TA;Seferovic, P;Wassmann, S;Walther, T;Lewis, BS (2018) 'Expert consensus document on the management of hyperkalaemia in patients with cardiovascular disease treated with renin angiotensin aldosterone system inhibitors: coordinated by the Working Group on Cardiovascular Pharmacotherapy of the European Society of Cardiology'. European Heart Journal Cardiovascular Pharmacotherapy, 4 :180-188 [DOI] [Details] | |
| (2018) | 'Decarboxylation of Ang-(1–7) to Ala1-Ang-(1–7) leads to significant changes in pharmacodynamics' Tetzner, Anja; Naughton, Maura; Gebolys, Kinga; Eichhorst, Jenny; Sala, Esther; Villacañas, Óscar; Walther, Thomas (2018) 'Decarboxylation of Ang-(1–7) to Ala1-Ang-(1–7) leads to significant changes in pharmacodynamics'. European Journal of Pharmacology, [DOI] [Full Text] [Details] | |
| (2018) | 'Non-insulin antidiabetic pharmacotherapy in patients with established cardiovascular disease: a position paper of the European Society of Cardiology Working Group on Cardiovascular Pharmacotherapy' Niessner, A;Tamargo, J;Koller, L;Saely, CH;Schmidt, TA;Savarese, G;Wassmann, S;Rosano, G;Ceconi, C;Torp-Pedersen, C;Kaski, JC;Kjeldsen, KP;Agewall, S;Walther, T;Drexel, H;Lewis, BS (2018) 'Non-insulin antidiabetic pharmacotherapy in patients with established cardiovascular disease: a position paper of the European Society of Cardiology Working Group on Cardiovascular Pharmacotherapy'. European Heart Journal, 39 :2274-2281 [DOI] [Details] | |
| (2017) | 'Gender Differences in the effects of cardiovascular drugs' Tamargo J, Rosano G, Walther T, Duarte J, Niessner A, Kaski JC, Cecconi C, Drexel H, Kjeldsen K, Savarese G, Torp-Pedersen C, Atar D, Lewis BS, Agewall S. (2017) 'Gender Differences in the effects of cardiovascular drugs'. Eur Heart Jeur Heart J, [Details] | |
| (2017) | 'Further intracellular proteins and signaling pathways regulated by angiotensin-(1-7) in human endothelial cells' Meinert, C;Kohse, F;Bohme, I;Gembardt, F;Tetzner, A;Wieland, T;Greenberg, B;Walther, T (2017) 'Further intracellular proteins and signaling pathways regulated by angiotensin-(1-7) in human endothelial cells'. Data In Brief, 10 :354-363 [DOI] [Details] | |
| (2016) | 'Role of Monokine Induced by Interferon Gamma in Discrimination and Prognosis of Patients With Chagas' Disease and Idiopathic Dilated Cardiomyopathy' Khan, A,Wang, Y,Schultheiss, HP,Moreira, MDV,Walther, T (2016) 'Role of Monokine Induced by Interferon Gamma in Discrimination and Prognosis of Patients With Chagas' Disease and Idiopathic Dilated Cardiomyopathy'. Journal of cardiovascular pharmacology, 67 :427-432 [Details] | |
| (2016) | 'Role of Monokine Induced by Interferon Gamma in Discrimination and Prognosis of Patients With Chagas' Disease and Idiopathic Dilated Cardiomyopathy' Khan A;Wang Y;Schultheiss HP;Moreira Mda C;Walther T; (2016) 'Role of Monokine Induced by Interferon Gamma in Discrimination and Prognosis of Patients With Chagas' Disease and Idiopathic Dilated Cardiomyopathy'. Journal of cardiovascular pharmacology, (67):427-432 [DOI] [Details] | |
| (2016) | 'Identification of intracellular proteins and signaling pathways in human endothelial cells regulated by angiotensin-(1-7)' Meinert C, Gembardt F;B¿¿hme I;Tetzner A;Wieland T;Greenberg B;Walther T (2016) 'Identification of intracellular proteins and signaling pathways in human endothelial cells regulated by angiotensin-(1-7)'. Journal of Proteomics, 130 :129-139 [DOI] [Details] | |
| (2016) | 'Therapeutic time window for angiotensin-(1-7) in acute lung injury' Sup¿¿ S, Kohse F;Gembardt F;Kuebler WM;Walther T (2016) 'Therapeutic time window for angiotensin-(1-7) in acute lung injury'. British journal of pharmacology, 173 (10):1618-1628 [DOI] [Details] | |
| (2016) | 'Angiotensin receptors and beta-catenin regulate brain endothelial integrity in malaria' Gallego-Delgado, J,Basu-Roy, U,Ty, M,Alique, M,Fernandez-Arias, C,Movila, A,Gomes, P,Weinstock, A,Xu, WY,Edagha, I,Wassmer, SC,Walther, T,Ruiz-Ortega, M,Rodriguez, A (2016) 'Angiotensin receptors and beta-catenin regulate brain endothelial integrity in malaria'. Journal of Clinical Investigation, 126 :4016-4029 [DOI] [Details] | |
| (2015) | 'Beta Blockers Prevent Correlation of Plasma ACE2 Activity With Echocardiographic Parameters in Patients With Idiopathic Dilated Cardiomyopathy' Wang, Y;Moreira, MDV;Heringer-Walther, S;Schultheiss, HP;Siems, WE;Wessel, N;Walther, T (2015) 'Beta Blockers Prevent Correlation of Plasma ACE2 Activity With Echocardiographic Parameters in Patients With Idiopathic Dilated Cardiomyopathy'. Journal of cardiovascular pharmacology, 65 :8-12 [Details] | |
| (2015) | 'Hemodynamic Effects of the Non-Peptidic Angiotensin-(1-7) Agonist AVE0991 in Liver Cirrhosis' Klein, S;Herath, CB;Schierwagen, R;Grace, J;Haltenhof, T;Uschner, FE;Strassburg, CP;Sauerbruch, T;Walther, T;Angus, PW;Trebicka, J (2015) 'Hemodynamic Effects of the Non-Peptidic Angiotensin-(1-7) Agonist AVE0991 in Liver Cirrhosis'. Plos One, 10 [DOI] [Details] | |
| (2017) | 'Non-insulin antidiabetic pharmaotherapy in patients with established cardiovascular disease' Niessner A, Tamargo J, Koller L, Saely CH, Schmidt TA, Savarese G, Wassmann S, Rosano G, Ceconi C, Torp-Pedersen C, Kaski JC, Kjeldsen KP, Agewall S, Walther T, Drexel H, Lewis BS (2017) 'Non-insulin antidiabetic pharmaotherapy in patients with established cardiovascular disease'. Eur Heart Jeur Heart J, [Details] | |
| (2017) | 'Comprehensive efforts to increase adherence to statin therapy' Vonbank, A;Agewall, S;Kjeldsen, KP;Lewis, BS;Torp-Pedersen, C;Ceconi, C;Funck-Brentano, C;Kaski, JC;Niessner, A;Tamargo, J;Walther, T;Wassmann, S;Rosano, G;Schmidt, H;Saely, CH;Drexel, H (2017) 'Comprehensive efforts to increase adherence to statin therapy'. European Heart Journal, 38 :2473-112 [DOI] [Details] | |
| (2017) | 'Angiotensin-(1-7) counteracts the transforming effects triggered by angiotensin II in breast cancer cells' Cambados, N;Walther, T;Nahmod, K;Tocci, JM;Rubinstein, N;Bohme, I;Simian, M;Sampayo, R;Suberbordes, MD;Kordon, EC;Schere-Levy, C (2017) 'Angiotensin-(1-7) counteracts the transforming effects triggered by angiotensin II in breast cancer cells'. Oncotarget, 8 :88475-88487 [DOI] [Details] | |
| (2017) | 'Mas receptor is involved in the estrogen-receptor induced nitric oxide-dependent vasorelaxation' Sobrino, A;Vallejo, S;Novella, S;Lazaro-Franco, M;Mompeon, A;Bueno-Beti, C;Walther, T;Sanchez-Ferrer, C;Peiro, C;Hermenegildo, C (2017) 'Mas receptor is involved in the estrogen-receptor induced nitric oxide-dependent vasorelaxation'. Biochemical Pharmacology, 129 :67-72 [DOI] [Details] | |
| (2016) | 'Green Tea reduces body fat via upregulation of neprilysin' Münzner M;Tappenbeck N;Gembardt F;Rülke R;Furkert J;Melzig MF;Siems WE;Brockmann GA;Walther T; (2016) 'Green Tea reduces body fat via upregulation of neprilysin'. International journal of obesity (2005), (40):1850-1855 [DOI] [Details] | |
| (2016) | 'The Angiotensin-(1-7)/Mas axis improves pancreatic ß-cell function in vitro and in vivo' Sahr A;Wolke C;Maczewsky J;Krippeit-Drews P;Tetzner A;Drews G;Venz S;Gürtler S;van den Brandt J;Berg S;Döring P;Dombrowski F;Walther T;Lendeckel U; (2016) 'The Angiotensin-(1-7)/Mas axis improves pancreatic ß-cell function in vitro and in vivo'. Endocrinology, (157):4677-4690 [DOI] [Details] | |
| (2016) | 'The High Blood Pressure-Malaria Protection Hypothesis' Gallego-Delgado J;Walther T;Rodriguez A; (2016) 'The High Blood Pressure-Malaria Protection Hypothesis'. Circulation Research, (119):1046-1048 [DOI] [Details] | |
| (2016) | 'Identification of intracellular proteins and signaling pathways in human endothelial cells regulated by angiotensin-(1-7)' Meinert, C;Gembardt, F;Bohme, I;Tetzner, A;Wieland, T;Greenberg, B;Walther, T (2016) 'Identification of intracellular proteins and signaling pathways in human endothelial cells regulated by angiotensin-(1-7)'. Journal of Proteomics, 130 :129-139 [DOI] [Details] | |
| (2016) | 'Age-Dependent Changes in the Pulmonary Renin-Angiotensin System Are Associated With Severity of Lung Injury in a Model of Acute Lung Injury in Rats' Schouten LR;Helmerhorst HJ;Wagenaar GT;Haltenhof T;Lutter R;Roelofs JJ;van Woensel JB;van Kaam AH;Bos AP;Schultz MJ;Walther T;Wösten-van Asperen RM; (2016) 'Age-Dependent Changes in the Pulmonary Renin-Angiotensin System Are Associated With Severity of Lung Injury in a Model of Acute Lung Injury in Rats'. Critical Care Medicine, (44):e1226-e1235 [DOI] [Details] | |
| (2016) | 'G-Protein-Coupled Receptor MrgD Is a Receptor for Angiotensin-(1-7) Involving Adenylyl Cyclase, cAMP, and Phosphokinase A' Tetzner, A;Gebolys, K;Meinert, C;Klein, S;Uhlich, A;Trebicka, J;Villacanas, O;Walther, T (2016) 'G-Protein-Coupled Receptor MrgD Is a Receptor for Angiotensin-(1-7) Involving Adenylyl Cyclase, cAMP, and Phosphokinase A'. Journal of Hypertension, 68 :185-194 [DOI] [Details] | |
| (2016) | 'Angiotensin receptors and ß-catenin regulate brain endothelial integrity in malaria' Gallego-Delgado J;Basu-Roy U;Ty M;Alique M;Fernandez-Arias C;Movila A;Gomes P;Weinstock A;Xu W;Edagha I;Wassmer SC;Walther T;Ruiz-Ortega M;Rodriguez A; (2016) 'Angiotensin receptors and ß-catenin regulate brain endothelial integrity in malaria'. Journal of Clinical Investigation, (126):4016-4029 [DOI] [Details] | |
| (2016) | 'Rare Variants in MME, Encoding Metalloprotease Neprilysin, Are Linked to Late-Onset Autosomal-Dominant Axonal Polyneuropathies' Auer-Grumbach M;Toegel S;Schabhüttl M;Weinmann D;Chiari C;Bennett DL;Beetz C;Klein D;Andersen PM;Böhme I;Fink-Puches R;Gonzalez M;Harms MB;Motley W;Reilly MM;Renner W;Rudnik-Schöneborn S;Schlotter-Weigel B;Themistocleous AC;Weishaupt JH;Ludolph AC;Wieland T;Tao F;Abreu L;Windhager R;Zitzelsberger M;Strom TM;Walther T;Scherer SS;Züchner S;Martini R;Senderek J; (2016) 'Rare Variants in MME, Encoding Metalloprotease Neprilysin, Are Linked to Late-Onset Autosomal-Dominant Axonal Polyneuropathies'. American Journal of Human Genetics, (99):607-623 [DOI] [Details] | |
| (2016) | 'Role of monokine induced by interferon-gamma (MIG) in discrimination and prognosis of patients with Chagas' disease and idiopathic dilated cardiomyopathy' Khan A, Wang Y;Schultheiss HP;Moreira MD;Walther T (2016) 'Role of monokine induced by interferon-gamma (MIG) in discrimination and prognosis of patients with Chagas' disease and idiopathic dilated cardiomyopathy'. Journal of cardiovascular pharmacology, (67):427-432 [DOI] [Details] | |
| (2016) | 'Therapeutic time window for angiotensin-(1-7) in acute lung injury' Supe, S;Kohse, F;Gembardt, F;Kuebler, WM;Walther, T (2016) 'Therapeutic time window for angiotensin-(1-7) in acute lung injury'. British Journal of Pharmacology, 173 :1618-1628 [DOI] [Details] | |
| (2015) | 'Disease Management:Cardiovascular safety of anti-diabetic drugs' Kumar, R., Kerins D.M, Walther, T. M. (2015) 'Disease Management:Cardiovascular safety of anti-diabetic drugs'. European Heart Journal Cardiovascular Pharmacotherapy, (2):32-43 [Details] | |
| (2015) | 'Multiple non-coding exons and alternative splicing in the mouse Mas protooncogene' Alenina, N;Boehme, I;Bader, M;Walther, T (2015) 'Multiple non-coding exons and alternative splicing in the mouse Mas protooncogene'. Gene, 568 :155-164 [DOI] [Details] | |
| (2015) | 'Diagnosis and Treatment of Hypertensive Pregnancy Disorders. Guideline of DGGG (S1-Level, AWMF Registry No. 015/018, December 2013)' Stepan, H;Kuse-Fohl, S;Klockenbusch, W;Rath, W;Schauf, B;Walther, T;Schlembach, D (2015) 'Diagnosis and Treatment of Hypertensive Pregnancy Disorders. Guideline of DGGG (S1-Level, AWMF Registry No. 015/018, December 2013)'. Geburtshilfe Und Frauenheilkunde, 75 :900-913 [DOI] [Details] | |
| (2015) | 'Beta Blockers Prevent Correlation of Plasma ACE2 Activity With Echocardiographic Parameters in Patients With Idiopathic Dilated Cardiomyopathy' Wang, Y,Moreira, MDV,Heringer-Walther, S,Schultheiss, HP,Siems, WE,Wessel, N,Walther, T (2015) 'Beta Blockers Prevent Correlation of Plasma ACE2 Activity With Echocardiographic Parameters in Patients With Idiopathic Dilated Cardiomyopathy'. Journal of cardiovascular pharmacology, 65 :8-12 [Details] | |
| (2015) | 'Dose-dependent, therapeutic potential of angiotensin-(1-7) for the treatment of pulmonary arterial hypertension' Breitling, S;Krauszman, A;Parihar, R;Walther, T;Friedberg, MK;Kuebler, WM (2015) 'Dose-dependent, therapeutic potential of angiotensin-(1-7) for the treatment of pulmonary arterial hypertension'. Pulmonary circulation, 5 :649-657 [DOI] [Details] | |
| (2015) | 'Hemodynamic Effects of the Non-Peptidic Angiotensin-(1-7) Agonist AVE0991 in Liver Cirrhosis' Klein S, Herath CB;Schierwagen R;Grace J;Haltenhof T;Uschner FE;Strassburg CP;Sauerbruch T;Walther T;Angus PW;Trebicka J (2015) 'Hemodynamic Effects of the Non-Peptidic Angiotensin-(1-7) Agonist AVE0991 in Liver Cirrhosis'. Plos One, (e0138732):1-14 [DOI] [Details] | |
| (2015) | 'Dose-dependent, therapeutic potential of angiotensin-(1-7) for the treatment of pulmonary arterial hypertension' Breitling S, Krauszman A;Parihar R;Walther T;Friedberg MK;Kuebler WM (2015) 'Dose-dependent, therapeutic potential of angiotensin-(1-7) for the treatment of pulmonary arterial hypertension'. Pulmonary circulation, 5 (4):649-657 [DOI] [Details] | |
| (2014) | 'Sphingosine-1-Phosphate as a Potential Target for the Treatment of Myocardial Infarction' Waeber C, Walther T. (2014) 'Sphingosine-1-Phosphate as a Potential Target for the Treatment of Myocardial Infarction'. Circulation Journal, (78):795-802 [Details] | |
| (2014) | 'Effects of the angiotensin-(1-7) receptor Mas on cell proliferation and on the population of doublecortin positive cells within the dentate gyrus and the piriform cortex' Freund, M,Walther, T,Halbach, OVU (2014) 'Effects of the angiotensin-(1-7) receptor Mas on cell proliferation and on the population of doublecortin positive cells within the dentate gyrus and the piriform cortex'. European Neuropsychopharmacology, 24 :302-308 [DOI] [Details] | |
| (2013) | 'Angiotensin-(1-7) Protects From Experimental Acute Lung Injury' Klein, N;Gembardt, F;Supe, S;Kaestle, SM;Nickles, H;Erfinanda, L;Lei, XH;Yin, J;Wang, LM;Mertens, M;Szaszi, K;Walther, T;Kuebler, WM (2013) 'Angiotensin-(1-7) Protects From Experimental Acute Lung Injury'. Critical Care Medicine, 41 :334-343 [DOI] [Details] | |
| (2013) | 'Activation of the Mas Receptor by Angiotensin-(1-7) in the Renin-Angiotensin System Mediates Mesenteric Vasodilatation in Cirrhosis' Grace, JA;Klein, S;Herath, CB;Granzow, M;Schierwagen, R;Masing, N;Walther, T;Sauerbruch, T;Burrell, LM;Angus, PW;Trebicka, J (2013) 'Activation of the Mas Receptor by Angiotensin-(1-7) in the Renin-Angiotensin System Mediates Mesenteric Vasodilatation in Cirrhosis'. Gastroenterology, (145):874-884 [DOI] [Details] | |
| (2014) | 'Cardiovascular variability before and after delivery: recovery from arterial stiffness in women with preeclampsia 4 days post partum' Walther T, Voss A, Baumert M, Truebner S, Till H, Stepan H, Wessel N, Faber R. (2014) 'Cardiovascular variability before and after delivery: recovery from arterial stiffness in women with preeclampsia 4 days post partum'. Hypertension in pregnancy : official journal of the International Society for the Study of Hypertension in Pregnancy, 33 :1-14 [DOI] [Details] | |
| (2014) | 'Effects of the angiotensin-(1-7) receptor Mas on cell proliferation and on the population of doublecortin positive cells within the dentate gyrus and the piriform cortex' Freund M, Walther T, von Bohlen Und Halbach O. (2014) 'Effects of the angiotensin-(1-7) receptor Mas on cell proliferation and on the population of doublecortin positive cells within the dentate gyrus and the piriform cortex'. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 24 (2):302-308 [DOI] [Details] | |
| (2013) | 'Prognostic value of circulating levels of stem cell growth factor beta (SCGF beta) in patients with Chagas' disease and idiopathic dilated cardiomyopathy' Wang Y, Khan A, Heringer-Walther S, Schultheiss HP, Moreira Mda C, Walther T. (2013) 'Prognostic value of circulating levels of stem cell growth factor beta (SCGF beta) in patients with Chagas' disease and idiopathic dilated cardiomyopathy'. Cytokine, (61):728-733 [Details] | |
| (2013) | 'Classification of cardiovascular time series based on different coupling structures using recurrence networks analysis' Ramírez Ávila GM, Gapelyuk A, Marwan N, Walther T, Stepan H, Kurths J, Wessel N. (2013) 'Classification of cardiovascular time series based on different coupling structures using recurrence networks analysis'. Philosophical transactions. Series A, Mathematical, physical, and engineering sciences, (371) [DOI] [Details] | |
| (2013) | 'Classifying healthy women and preeclamptic patients from cardiovascular data using recurrence and complex network methods' Ramírez Ávila GM, Gapelyuk A, Marwan N, Stepan H, Kurths J, Walther T, Wessel N. (2013) 'Classifying healthy women and preeclamptic patients from cardiovascular data using recurrence and complex network methods'. Autonomic neuroscience : basic & clinical, 178 (1-2):103-110 [DOI] [Details] | |
| (2013) | 'A Small Molecule Angiotensin II Type 2 Receptor (AT(2)R) Antagonist Produces Analgesia in a Rat Model of Neuropathic Pain by Inhibition of p38 Mitogen-Activated Protein Kinase (MAPK) and p44/p42 MAPK Activation in the Dorsal Root Ganglia' Smith MT, Woodruff TM, Wyse BD, Muralidharan A, Walther T. (2013) 'A Small Molecule Angiotensin II Type 2 Receptor (AT(2)R) Antagonist Produces Analgesia in a Rat Model of Neuropathic Pain by Inhibition of p38 Mitogen-Activated Protein Kinase (MAPK) and p44/p42 MAPK Activation in the Dorsal Root Ganglia'. Pain medicine (Malden, Mass.), (14):1557-1568 [DOI] [Details] | |
| (2013) | 'Chimeric natriuretic peptide ACNP stimulates both natriuretic peptide receptors, the NPRA and NPRB' Zhu X, Wang Y, Schwiebs A, Walther T. (2013) 'Chimeric natriuretic peptide ACNP stimulates both natriuretic peptide receptors, the NPRA and NPRB'. Molecular Cell Endocrinology, 366 (11):117-23117 [Details] | |
| (2013) | 'Elevation of angiotensin-II type-1-receptor autoantibodies titer in primary aldosteronism as a result of aldosterone-producing adenoma' Rossitto G, Regolisti G, Rossi E, Negro A, Nicoli D, Casali B, Toniato A, Caroccia B, Seccia TM, Walther T, Rossi GP. (2013) 'Elevation of angiotensin-II type-1-receptor autoantibodies titer in primary aldosteronism as a result of aldosterone-producing adenoma'. Hypertension, 61 (22):526-33526 [Details] | |
| (2013) | 'Complete blockade of the vasorelaxant effects of angiotensin-(1-7) and bradykinin in murine microvessels by antagonists of the receptor Mas' Peiro C, Vallejo S, Gembardt F, Palacios E, Novella S, Azcutia V, Rodriguez-Manas L, Hermenegildo C, Sanchez-Ferrer CF, Walther T. (2013) 'Complete blockade of the vasorelaxant effects of angiotensin-(1-7) and bradykinin in murine microvessels by antagonists of the receptor Mas'. American Journal of Physiology, (591):2275-2285 [Details] | |
| (2012) | 'Hemodynamic effects of vasorelaxant compounds in mice lacking one, two or all three angiotensin II receptors' Gembardt F, van Veghel R, Coffman TM, Schultheiss HP, Danser AH, Walther T. (2012) 'Hemodynamic effects of vasorelaxant compounds in mice lacking one, two or all three angiotensin II receptors'. Hypertension, 35 (55):547-51547 [Details] | |
| (2012) | 'Genetic deficiency in neprilysin or its pharmacological inhibition initiate excessive stress-induced alcohol consumption in mice' Maul B, Becker M, Gembardt F, Becker A, Schultheiss HP, Siems WE, Walther T. (2012) 'Genetic deficiency in neprilysin or its pharmacological inhibition initiate excessive stress-induced alcohol consumption in mice'. Plos One, 7 (11) [Details] | |
| (2012) | 'Immunohistochemical localization of the angiotensin-(1-7) receptor Mas in the murine forebrain' Freund M, Walther T, von Bohlen und Halbach O. (2012) 'Immunohistochemical localization of the angiotensin-(1-7) receptor Mas in the murine forebrain'. Cell Tissue Research, (348):29-35 [DOI] [Details] | |
| (2012) | 'AT1 receptor blockade delays postlactational mammary gland involution: a novel role for the renin angiotensin system' Nahmod KA, Walther T, Cambados N, Fernandez N, Meiss R, Tappenbeck N, Wang Y, Raffo D, Simian M, Schwiebs A, Pozner RG, Fuxman Bass JI, Pozzi AG, Geffner JR, Kordon EC, Schere-Levy C. (2012) 'AT1 receptor blockade delays postlactational mammary gland involution: a novel role for the renin angiotensin system'. Faseb Journal, (26):1982-1994 [Details] | |
| (2012) | 'Prognostic Significance of Circulating Levels of Hepatocyte Growth Factor in Patients with Chagas' Disease and Idiopathic Dilated Cardiomyopathy' Wang Y, Moreira MD, Khan A, Heringer-Walther S, Schultheiss HP, Wessel N, Siems WE, Walther T. (2012) 'Prognostic Significance of Circulating Levels of Hepatocyte Growth Factor in Patients with Chagas' Disease and Idiopathic Dilated Cardiomyopathy'. Cardiology, (121):240-246 [Details] | |
| (2012) | 'The genetic deletion of Mas abolishes salt induced hypertension in mice' Heringer-Walther S, Gembardt F, Perschel FH, Katz N, Schultheiss HP, Walther T. (2012) 'The genetic deletion of Mas abolishes salt induced hypertension in mice'. European Journal of Pharmacology, (689):147-153 [Details] | |
| (2011) | 'Identification of a female sex pheromone in Carcius maenas' Hardege J, Bartels-Hardege H, Fletcher N, Terschak M, Harley J, Smith M, Davidson L, Hayden D, Mueller C, Lorch M, Welham K, Walther T, Bublitz R. (2011) 'Identification of a female sex pheromone in Carcius maenas'. Marine Ecology Progress Series, (436):177-189 [Details] | |
| (2011) | 'Effects of the renin angiotensin system on vasculogenesis-related progenitor cells' Roks, A. J.,Rodgers, K.,Walther, T. (2011) 'Effects of the renin angiotensin system on vasculogenesis-related progenitor cells'. Current Opinion In Pharmacology, (11):162-174 [Details] | |
| (2011) | 'Pressor and renal hemodynamic effects of the novel angiotensin A peptide are angiotensin II type 1A receptor dependent' Yang R, Smolders I, Vanderheyden P, Demaegdt H, Van Eeckhaut A, Vauquelin G, Lukaszuk A, Tourwe D, Chai SY, Albiston AL, Nahmias C, Walther T, Dupont AG. (2011) 'Pressor and renal hemodynamic effects of the novel angiotensin A peptide are angiotensin II type 1A receptor dependent'. Hypertension, 57 (55):956-64956 [Details] | |
| (2011) | 'Does the aminopeptidase A have prognostic and diagnostic value in Chagas disease and other dilated cardiomyopathies?' Wang Y, Moreira Mda C, Heringer-Walther S, Khan A, Schultheiss HP, Wessel N, Siems WE, Walther T. (2011) 'Does the aminopeptidase A have prognostic and diagnostic value in Chagas disease and other dilated cardiomyopathies?'. Journal of Cardiovascular Pharmacology, 58 (44):374-9374 [Details] | |
| (2011) | 'High-protein diet in lactation leads to a sudden infant death-like syndrome in mice' Walther T, Dietrich N, Langhammer M, Kucia M, Hammon H, Renne U, Siems WE, Metges CC. (2011) 'High-protein diet in lactation leads to a sudden infant death-like syndrome in mice'. Plos One, (6) [Details] | |
| (2011) | 'Functional expression of angiotensinogen depends on splicing enhancers in exon 2' Cardoso CC, Cabrini DA, May M, Bhagat CS, Eleno N, Cayla C, Walther T, Bader M. (2011) 'Functional expression of angiotensinogen depends on splicing enhancers in exon 2'. Molecular Cell Endocrinology, 332 (1-21-2):228-33228 [Details] | |
| (2010) | 'Renal ACE2 expression and activity is unaltered during established hypertension in adult SHRSP and TGR(mREN2)27' Kamilic, J.,Hamming, I.,Kreutz, R.,Bolbrinker, J.,Siems, W. E.,Nassar, I.,Sluimer, J. C.,Walther, T.,Navis, G. J.,van Goor, H. (2010) 'Renal ACE2 expression and activity is unaltered during established hypertension in adult SHRSP and TGR(mREN2)27'. Hypertens Res, 33 (22):123-8123 [Details] | |
| (2010) | 'Effects of ACE2 inhibition in the post-myocardial infarction heart' Kim MA, Yang D, Kida K, Molotkova N, Yeo SJ, Varki N, Iwata M, Dalton ND, Peterson KL, Siems WE, Walther T, Cowling RT, Kjekshus J, Greenberg B. (2010) 'Effects of ACE2 inhibition in the post-myocardial infarction heart'. Journal of Cardiac Failure, 16 (99):777-85777 [Details] | |
| (2010) | 'Impaired function of dendritic cells deficient in angiotensin II type 1 receptors' Nahmod, K.,Gentilini, C.,Vermeulen, M.,Uharek, L.,Wang, Y.,Zhang, J.,Schultheiss, H. P.,Geffner, J.,Walther, T. (2010) 'Impaired function of dendritic cells deficient in angiotensin II type 1 receptors'. Journal of Pharmacology and Experimental Therapeutics, 334 (33):854-62854 [Details] | |
| (2010) | 'Angiotensin II type 1a-deficient bone marrow-derived dendritic cells produce higher levels of monocyte chemoattractant protein 1' Nahmod KA, Geffner JR, Walther T. (2010) 'Angiotensin II type 1a-deficient bone marrow-derived dendritic cells produce higher levels of monocyte chemoattractant protein 1'. Hypertension, 56 (11):6-7 [Details] | |
| (2010) | 'Expression of angiotensin type 1A receptors in C1 neurons restores the sympathoexcitation to angiotensin in the rostral ventrolateral medulla of angiotensin type 1A knockout mice' Chen D, Bassi JK, Walther T, Thomas WG, Allen AM. (2010) 'Expression of angiotensin type 1A receptors in C1 neurons restores the sympathoexcitation to angiotensin in the rostral ventrolateral medulla of angiotensin type 1A knockout mice'. Hypertension, 56 (11):143-50143 [Details] | |
| (2010) | 'New function for an old enzyme: NEP deficient mice develop late-onset obesity' Becker M, Siems WE, Kluge R, Gembardt F, Schultheiss HP, Schirner M, Walther T. (2010) 'New function for an old enzyme: NEP deficient mice develop late-onset obesity'. Plos One, 5 (99) [Details] | |
| (2010) | 'Renal vasoconstrictor and pressor responses to angiotensin IV in mice are AT1a-receptor mediated' Yang R, Walther T, Gembardt F, Smolders I, Vanderheyden P, Albiston AL, Chai SY, Dupont AG. (2010) 'Renal vasoconstrictor and pressor responses to angiotensin IV in mice are AT1a-receptor mediated'. Hypertension, 28 (33):487-94487 [Details] | |
| (2010) | 'Circulating rather than cardiac angiotensin-(1-7) stimulates cardioprotection after myocardial infarction' Wang Y, Qian C, Roks AJ, Westermann D, Schumacher SM, Escher F, Schoemaker RG, Reudelhuber TL, van Gilst WH, Schultheiss HP, Tschope C, Walther T. (2010) 'Circulating rather than cardiac angiotensin-(1-7) stimulates cardioprotection after myocardial infarction'. European Journal of Heart Failure, 3 (22):286-93286 [Details] | |
| (2010) | 'Amino-terminal fragment of C-type natriuretic peptide precursor and C-type natriuretic peptide do not correlate in patients with Chagas disease: role for neutral endopeptidase' Wang Y, Moreira Mda C, Heringer-Walther S Schultheiss HP, Siems WE, Wessel N, Walther T. (2010) 'Amino-terminal fragment of C-type natriuretic peptide precursor and C-type natriuretic peptide do not correlate in patients with Chagas disease: role for neutral endopeptidase'. Journal of Cardiovascular Pharmacology, 55 (11):62-662 [Details] | |
| (2010) | 'Plasma ACE2 activity is an independent prognostic marker in Chagas' disease and equally potent as BNP' Wang Y, Moreira Mda C, Heringer-Walther S, Ebermann L, Schultheiss HP, Wessel N, Siems WE, Walther T. (2010) 'Plasma ACE2 activity is an independent prognostic marker in Chagas' disease and equally potent as BNP'. Journal of Cardiac Failure, 16 (22):157-63157 [Details] | |
| (2010) | 'Cardiac phenotype and angiotensin II levels in AT1a, AT1b, and AT2 receptor single, double, and triple knockouts' van Esch JH, Gembardt F, Sterner-Kock A, Heringer-Walther S, Le TH, Lassner D, Stijnen T, Coffman TM, Schultheiss HP, Danser AH, Walther T. (2010) 'Cardiac phenotype and angiotensin II levels in AT1a, AT1b, and AT2 receptor single, double, and triple knockouts'. Cardiovascular Research, 86 (33):401-9401 [Details] | |
| (2010) | 'Angiotensin II subtype 2 receptor blockade and deficiency attenuate the development of atherosclerosis in an apolipoprotein E-deficient mouse model of diabetes' Koïtka A, Cao Z, Koh P, Watson AM, Sourris KC, Loufrani L, Soro-Paavonen A, Walther T, Woollard KJ, Jandeleit-Dahm KA, Cooper ME, Allen TJ. (2010) 'Angiotensin II subtype 2 receptor blockade and deficiency attenuate the development of atherosclerosis in an apolipoprotein E-deficient mouse model of diabetes'. Diabetologia, 53 (3):584-592 [DOI] [Details] | |
| (2010) | 'The day-night difference of blood pressure is increased in AT(1A)-receptor knockout mice on a high-sodium diet' Chen, D.,La Greca, L.,Head, G. A.,Walther, T.,Mayorov, D. N. (2010) 'The day-night difference of blood pressure is increased in AT(1A)-receptor knockout mice on a high-sodium diet'. Am J Hypertens, 23 (55):481-7481 [Details] | |
| (2010) | 'Receptor for AGEs (RAGE) blockade may exert its renoprotective effects in patients with diabetic nephropathy via induction of the angiotensin II type 2 (AT2) receptor' Sourris KC, Morley AL, Koitka A, Samuel P, Coughlan MT, Penfold SA, Thomas MC, Bierhaus A, Nawroth PP, Yamamoto H, Allen TJ, Walther T, Hussain T, Cooper ME, Forbes JM. (2010) 'Receptor for AGEs (RAGE) blockade may exert its renoprotective effects in patients with diabetic nephropathy via induction of the angiotensin II type 2 (AT2) receptor'. Diabetologia, 53 (11):2442-2451 [DOI] [Details] | |
| (2009) | 'Angiotensin-(1-7) with thioether bridge: an angiotensin-converting enzyme-resistant, potent angiotensin-(1-7) analog' Kluskens, L. D.,Nelemans, S. A.,Rink, R.,de Vries, L.,Meter-Arkema, A.,Wang, Y.,Walther, T.,Kuipers, A.,Moll, G. N.,Haas, M. (2009) 'Angiotensin-(1-7) with thioether bridge: an angiotensin-converting enzyme-resistant, potent angiotensin-(1-7) analog'. J Pharmacol Exp Ther, 328 (33):849-54849 [Details] | |
| (2009) | 'Improved learning and memory in aged mice deficient in amyloid beta-degrading neutral endopeptidase' Walther T, Albrecht D, Becker M, Schubert M, Kouznetsova E, Wiesner B, Maul B, Schliebs R, Grecksch G, Furkert J, Sterner-Kock A, Schultheiss, HP, Becker A, Siems WE. (2009) 'Improved learning and memory in aged mice deficient in amyloid beta-degrading neutral endopeptidase'. Plos One, 4 (22) [Details] | |
| (2009) | 'Gene deletion of the kinin receptor B1 attenuates cardiac inflammation and fibrosis during the development of experimental diabetic cardiomyopathy' Westermann D, Walther T, Savvatis K, Escher F, Sobirey M, Riad A, Bader M, Schultheiss HP, Tschope C. (2009) 'Gene deletion of the kinin receptor B1 attenuates cardiac inflammation and fibrosis during the development of experimental diabetic cardiomyopathy'. Diabetes, 58 (66):1373-811373 [Details] | |
| (2009) | 'Angiotensin-(1-7) and the g protein-coupled receptor MAS are key players in renal inflammation' Esteban, V.,Heringer-Walther, S.,Sterner-Kock, A.,de Bruin, R.,van den Engel, S.,Wang, Y.,Mezzano, S.,Egido, J.,Schultheiss, H. P.,Ruiz-Ortega, M.,Walther, T. (2009) 'Angiotensin-(1-7) and the g protein-coupled receptor MAS are key players in renal inflammation'. PLoS One, 4 (44) [Details] | |
| (2009) | 'Angiotensin-(1-7) stimulates hematopoietic progenitor cells in vitro and in vivo' Heringer-Walther, S.,Eckert, K.,Schumacher, S. M.,Uharek, L.,Wulf-Goldenberg, A.,Gembardt, F.,Fichtner, I.,Schultheiss, H. P.,Rodgers, K.,Walther, T. (2009) 'Angiotensin-(1-7) stimulates hematopoietic progenitor cells in vitro and in vivo'. Haematologica, 94 (66):857-60857 [Details] | |
| (2009) | 'Role of angiotensin II Type 1A receptors in cardiovascular reactivity and neuronal activation after aversive stress in mice' Davern, P. J.,Chen, D.,Head, G. A.,Chavez, C. A.,Walther, T.,Mayorov, D. N. (2009) 'Role of angiotensin II Type 1A receptors in cardiovascular reactivity and neuronal activation after aversive stress in mice'. Hypertension, 54 (66):1262-81262 [Details] | |
| (2009) | 'Excessive hypertension and end-organ damage in a transgenic mouse line carrying the rat angiotensinogen gene' Xu, P.,Wang, Y.,Sterner-Kock, A.,Bader, M.,Schultheiss, H. P.,Walther, T. (2009) 'Excessive hypertension and end-organ damage in a transgenic mouse line carrying the rat angiotensinogen gene'. J Cardiovasc Pharmacol, 53 (11):38-4338 [Details] | |
| (2009) | 'Blood pressure reactivity to emotional stress is reduced in AT1A-receptor knockout mice on normal, but not high salt intake' Chen, D.,La Greca, L.,Head, G. A.,Walther, T.,Mayorov, D. N. (2009) 'Blood pressure reactivity to emotional stress is reduced in AT1A-receptor knockout mice on normal, but not high salt intake'. Hypertens Res, 32 (77):559-64559 [Details] | |
| (2009) | 'Structural substrate conditions required for neutral endopeptidase-mediated natriuretic Peptide degradation' Pankow, K.,Schwiebs, A.,Becker, M.,Siems, W. E.,Krause, G.,Walther, T. (2009) 'Structural substrate conditions required for neutral endopeptidase-mediated natriuretic Peptide degradation'. J Mol Biol, 393 (22):496-503496 [Details] | |
| (2009) | 'Prognostic value of natriuretic peptides in Chagas' disease: a head-to-head comparison of the 3 natriuretic peptides' Moreira Mda, C.,Wang, Y.,Heringer-Walther, S.,Wessel, N.,Walther, T. (2009) 'Prognostic value of natriuretic peptides in Chagas' disease: a head-to-head comparison of the 3 natriuretic peptides'. Congest Heart Fail, 15 (22):75-8175 [Details] | |
| (2009) | 'Lack of evidence for AT1R/B2R heterodimerization in COS-7, HEK293, and NIH3T3 cells: how common is the AT1R/B2R heterodimer?' Hansen, J. L.,Hansen, J. T.,Speerschneider, T.,Lyngso, C.,Erikstrup, N.,Burstein, E. S.,Weiner, D. M.,Walther, T.,Makita, N.,Iiri, T.,Merten, N.,Kostenis, E.,Sheikh, S. P. (2009) 'Lack of evidence for AT1R/B2R heterodimerization in COS-7, HEK293, and NIH3T3 cells: how common is the AT1R/B2R heterodimer?'. J Biol Chem, 284 (33):1831-91831 [Details] | |
| (2009) | 'Myocardial overexpression of adenine nucleotide translocase 1 ameliorates diabetic cardiomyopathy in mice' Wang Y, Ebermann L, Sterner-Kock A, Wika S, Schultheiss HP, Dorner A, Walther T. (2009) 'Myocardial overexpression of adenine nucleotide translocase 1 ameliorates diabetic cardiomyopathy in mice'. Experimental Physiology, 94 (22):220-7220 [Details] | |
| (2009) | 'Candidate Agtr2 influenced genes and pathways identified by expression profiling in the developing brain of Agtr2(-/y) mice' Pawlowski T L, Heringer-Walther S, Cheng CH, Archie JG, Chen CF, Walther T, Srivastava AK. (2009) 'Candidate Agtr2 influenced genes and pathways identified by expression profiling in the developing brain of Agtr2(-/y) mice'. Genomics, 94 (33):188-95188 [Details] | |
| (2008) | 'The cardiovascular influence of interleukin-1 beta on the expression of bradykinin B1 and B2 receptors' Riad A, Walther T, Yang J, Altmann C, Escher F, Westermann D, Spillmann F, Schultheiss HP, Tschöpe C (2008) 'The cardiovascular influence of interleukin-1 beta on the expression of bradykinin B1 and B2 receptors'. International immunopharmacology, 8 (2):222-230 [DOI] [Details] | |
| (2008) | 'Catabolic attacks of membrane-bound angiotensin-converting enzyme on the N-terminal part of species-specific amyloid-beta peptides' Sun, X.,Becker, M.,Pankow, K.,Krause, E.,Ringling, M.,Beyermann, M.,Maul, B.,Walther, T.,Siems, W. E. (2008) 'Catabolic attacks of membrane-bound angiotensin-converting enzyme on the N-terminal part of species-specific amyloid-beta peptides'. Eur J Pharmacol, 588 (11):18-2518 [Details] | |
| (2008) | 'The angiotensin-(1-7) receptor agonist AVE0991 is cardioprotective in diabetic rats' Ebermann, L.,Spillmann, F.,Sidiropoulos, M.,Escher, F.,Heringer-Walther, S.,Schultheiss, H. P.,Tschope, C.,Walther, T. (2008) 'The angiotensin-(1-7) receptor agonist AVE0991 is cardioprotective in diabetic rats'. Eur J Pharmacol, 590 (1-31-3):276-80276 [Details] | |
| (2008) | 'Prognostic value of natriuretic peptides in Chagas' disease: a 3-year follow-up investigation' Moreira Mda, C.,Heringer-Walther, S.,Wessel, N.,Moreira Ventura, T.,Wang, Y.,Schultheiss, H. P.,Walther, T. (2008) 'Prognostic value of natriuretic peptides in Chagas' disease: a 3-year follow-up investigation'. Cardiology, 110 (44):217-25217 [Details] | |
| (2008) | 'Angiotensin(1-7) blunts hypertensive cardiac remodeling by a direct effect on the heart' Mercure, C.,Yogi, A.,Callera, G. E.,Aranha, A. B.,Bader, M.,Ferreira, A. J.,Santos, R. A.,Walther, T.,Touyz, R. M.,Reudelhuber, T. L. (2008) 'Angiotensin(1-7) blunts hypertensive cardiac remodeling by a direct effect on the heart'. Circ Res, 103 (1111):1319-261319 [Details] | |
| (2008) | 'Impaired spatial memory and altered dendritic spine morphology in angiotensin II type 2 receptor-deficient mice' Maul, B.,von Bohlen und Halbach, O.,Becker, A.,Sterner-Kock, A.,Voigt, J. P.,Siems, W. E.,Grecksch, G.,Walther, T. (2008) 'Impaired spatial memory and altered dendritic spine morphology in angiotensin II type 2 receptor-deficient mice'. J Mol Med (Berl), 86 (55):563-71563 [Details] | |
| (2008) | 'Characterization of the brain-specific non-AT(1), non-AT(2) angiotensin binding site in the mouse' Karamyan, V. T.,Gembardt, F.,Rabey, F. M.,Walther, T.,Speth, R. C. (2008) 'Characterization of the brain-specific non-AT(1), non-AT(2) angiotensin binding site in the mouse'. Eur J Pharmacol, 590 (1-31-3):87-9287 [Details] | |
| (2008) | 'Cardiovascular phenotype of mice lacking all three subtypes of angiotensin II receptors' Gembardt, F.,Heringer-Walther, S.,van Esch, J. H.,Sterner-Kock, A.,van Veghel, R.,Le, T. H.,Garrelds, I. M.,Coffman, T. M.,Danser, A. H.,Schultheiss, H. P.,Walther, T. (2008) 'Cardiovascular phenotype of mice lacking all three subtypes of angiotensin II receptors'. FASEB J, 22 (88):3068-773068 [Details] | |
| (2008) | 'Role of Ca2+/calmodulin-dependent protein kinase II in development of vascular dysfunction in diabetic rats with hypertension' Yousif, M. H.,Akhtar, S.,Walther, T.,Benter, I. F. (2008) 'Role of Ca2+/calmodulin-dependent protein kinase II in development of vascular dysfunction in diabetic rats with hypertension'. Cell Biochem Funct, 26 (22):256-63256 [Details] | |
| (2008) | 'Angiotensin metabolites can stimulate receptors of the Mas-related genes family' Gembardt, F.,Grajewski, S.,Vahl, M.,Schultheiss, H. P.,Walther, T. (2008) 'Angiotensin metabolites can stimulate receptors of the Mas-related genes family'. Mol Cell Biochem, 319 (1-21-2):115-23115 [Details] | |
| (2008) | 'Angiotensin II type 1 receptor has impact on murine placentation' Walther T, Jank A, Heringer-Walther S, Horn LC, Stepan H (2008) 'Angiotensin II type 1 receptor has impact on murine placentation'. Placenta, 29 (10):905-909 [DOI] [Details] | |
| (2008) | 'Inhibition of Ras-GTPase signaling by FPTIII ameliorates development of cardiovascular dysfunction in diabetic-hypertensive rats' Yousif, M. H.,Benter, I. F.,Abul, A. H.,Abraham, S.,Walther, T.,Akhtar, S. (2008) 'Inhibition of Ras-GTPase signaling by FPTIII ameliorates development of cardiovascular dysfunction in diabetic-hypertensive rats'. Vascul Pharmacol, 49 (4-64-6):151-7151 [Details] | |
| (2007) | 'Cardiomyocyte-restricted over-expression of C-type natriuretic peptide prevents cardiac hypertrophy induced by myocardial infarction in mice' Wang, Y.,de Waard, M. C.,Sterner-Kock, A.,Stepan, H.,Schultheiss, H. P.,Duncker, D. J.,Walther, T. (2007) 'Cardiomyocyte-restricted over-expression of C-type natriuretic peptide prevents cardiac hypertrophy induced by myocardial infarction in mice'. Eur J Heart Fail, 9 (6-76-7):548-57548 [Details] | |
| (2007) | 'Questionable role of the angiotensin II receptor subtype 1 autoantibody in the pathogenesis of preeclampsia' Stepan, H.,Walther, T. (2007) 'Questionable role of the angiotensin II receptor subtype 1 autoantibody in the pathogenesis of preeclampsia'. Hypertension, 50 (11) [Details] | |
| (2007) | 'Is parvovirus B19 the cause for autoimmunity against the angiotensin II type receptor?' Stepan, H.,Wallukat, G.,Schultheiss, H. P.,Faber, R.,Walther, T. (2007) 'Is parvovirus B19 the cause for autoimmunity against the angiotensin II type receptor?'. J Reprod Immunol, 73 (22):130-4130 [Details] | |
| (2007) | 'Endothelial dysfunction through genetic deletion or inhibition of the G protein-coupled receptor Mas: a new target to improve endothelial function' Peiro, C.,Vallejo, S.,Gembardt, F.,Azcutia, V.,Heringer-Walther, S.,Rodriguez-Manas, L.,Schultheiss, H. P.,Sanchez-Ferrer, C. F.,Walther, T. (2007) 'Endothelial dysfunction through genetic deletion or inhibition of the G protein-coupled receptor Mas: a new target to improve endothelial function'. J Hypertens, 25 (1212):2421-52421 [Details] | |
| (2007) | 'Successive action of meprin A and neprilysin catabolizes B-type natriuretic peptide' Pankow, K.,Wang, Y.,Gembardt, F.,Krause, E.,Sun, X.,Krause, G.,Schultheiss, H. P.,Siems, W. E.,Walther, T. (2007) 'Successive action of meprin A and neprilysin catabolizes B-type natriuretic peptide'. Circ Res, 101 (99):875-82875 [Details] | |
| (2007) | 'Immunofluorescence localization of the receptor Mas in cardiovascular-related areas of the rat brain' Becker, L. K.,Etelvino, G. M.,Walther, T.,Santos, R. A.,Campagnole-Santos, M. J. (2007) 'Immunofluorescence localization of the receptor Mas in cardiovascular-related areas of the rat brain'. Am J Physiol Heart Circ Physiol, 293 (33) [Details] | |
| (2007) | 'Agonist autoantibodies against the angiotensin AT1 receptor in renal and hypertensive disorders' Walther, T.,Stepan, H. (2007) 'Agonist autoantibodies against the angiotensin AT1 receptor in renal and hypertensive disorders'. Curr Hypertens Rep, 9 (22):128-32128 [Details] | |
| (2007) | 'The angiotensin-(1-7) receptor agonist AVE0991 dominates the circadian rhythm and baroreflex in spontaneously hypertensive rats' Wessel N, Malberg H, Heringer-Walther S, Schultheiss HP, Walther T (2007) 'The angiotensin-(1-7) receptor agonist AVE0991 dominates the circadian rhythm and baroreflex in spontaneously hypertensive rats'. Journal of cardiovascular pharmacology, 49 (2):67-73 [DOI] [Details] | |
| (2007) | 'Analysis of cardiovascular oscillations: a new approach to the early prediction of pre-eclampsia' Malberg H, Bauernschmitt R, Voss A, Walther T, Faber R, Stepan H, Wessel N (2007) 'Analysis of cardiovascular oscillations: a new approach to the early prediction of pre-eclampsia'. Chaos (Woodbury, N.Y.), 17 (1) [DOI] [Details] | |
| (2007) | 'Accelerated mitochondrial adenosine diphosphate/adenosine triphosphate transport improves hypertension-induced heart disease' Walther, T.,Tschope, C.,Sterner-Kock, A.,Westermann, D.,Heringer-Walther, S.,Riad, A.,Nikolic, A.,Wang, Y.,Ebermann, L.,Siems, W. E.,Bader, M.,Shakibaei, M.,Schultheiss, H. P.,Dorner, A. (2007) 'Accelerated mitochondrial adenosine diphosphate/adenosine triphosphate transport improves hypertension-induced heart disease'. Circulation, 115 (33):333-44333 [Details] | |
| (2006) | 'New insights into the biology of preeclampsia' Stepan, H.,Faber, R.,Dornhofer, N.,Huppertz, B.,Robitzki, A.,Walther, T. (2006) 'New insights into the biology of preeclampsia'. Biol Reprod, 74 (55):772-6772 [Details] | |
| (2006) | 'Comparison of three methods for beat-to-beat-interval extraction from continuous blood pressure and electrocardiogram with respect to heart rate variability analysis' Suhrbier, A.,Heringer, R.,Walther, T.,Malberg, H.,Wessel, N. (2006) 'Comparison of three methods for beat-to-beat-interval extraction from continuous blood pressure and electrocardiogram with respect to heart rate variability analysis'. Biomed Tech (Berl), 51 (22):70-670 [Details] | |
| (2006) | 'AT2 receptor-mediated vasodilation in the mouse heart depends on AT1A receptor activation' van Esch, J. H.,Schuijt, M. P.,Sayed, J.,Choudhry, Y.,Walther, T.,Jan Danser, A. H. (2006) 'AT2 receptor-mediated vasodilation in the mouse heart depends on AT1A receptor activation'. Br J Pharmacol, 148 (44):452-8452 [Details] | |
| (2006) | 'Autonomic cardiovascular control in pregnancies with abnormal uterine perfusion' Voss, A.,Baumert, M.,Baier, V.,Stepan, H.,Walther, T.,Faber, R. (2006) 'Autonomic cardiovascular control in pregnancies with abnormal uterine perfusion'. Am J Hypertens, 19 (33):306-12306 [Details] | |
| (2006) | 'Relation between circulating angiotensin II type 1 receptor agonistic autoantibodies and soluble fms-like tyrosine kinase 1 in the pathogenesis of preeclampsia' Stepan H, Faber R, Wessel N, Wallukat G, Schultheiss HP, Walther T (2006) 'Relation between circulating angiotensin II type 1 receptor agonistic autoantibodies and soluble fms-like tyrosine kinase 1 in the pathogenesis of preeclampsia'. The Journal of Clinical Endocrinology and Metabolism, 91 (6):2424-2427 [DOI] [Details] | |
| (2006) | 'Lack of angiotensin II conversion to angiotensin III increases water but not alcohol consumption in aminopeptidase A-deficient mice' Faber, F.,Gembardt, F.,Sun, X.,Mizutani, S.,Siems, W. E.,Walther, T. (2006) 'Lack of angiotensin II conversion to angiotensin III increases water but not alcohol consumption in aminopeptidase A-deficient mice'. Regul Pept, 136 (1-31-3):130-7130 [Details] | |
| (2006) | 'Carvedilol-induced antagonism of angiotensin II: a matter of alpha1-adrenoceptor blockade' Batenburg, W. W.,van Esch, J. H.,Garrelds, I. M.,Jorde, U.,Lamers, J. M.,Dekkers, D. H.,Walther, T.,Kellett, E.,Milligan, G.,van Kats, J. P.,Danser, A. H. (2006) 'Carvedilol-induced antagonism of angiotensin II: a matter of alpha1-adrenoceptor blockade'. J Hypertens, 24 (77):1355-631355 [Details] | |
| (2006) | 'Cloning of the porcine a2b adrenoceptor: Tissue distribution and pharmacological characterization' Mehrota S, Zhang J, Teunissen A, Saxena P, Vandenbrink A, Walther T, Sharma H (2006) 'Cloning of the porcine a2b adrenoceptor: Tissue distribution and pharmacological characterization'. European Journal of Pharmacology, (545):115-122 [Details] | |
| (2006) | 'Interactions between angiotensin ll and atrial natriuretic peptide in renomedullary interstitial cells: the role of neutral endopeptidase' Maric, C.,Zheng, W.,Walther, T. (2006) 'Interactions between angiotensin ll and atrial natriuretic peptide in renomedullary interstitial cells: the role of neutral endopeptidase'. Nephron Physiol, 103 (33) [Details] | |
| (2006) | 'Cardiac function and remodeling is attenuated in transgenic rats expressing the human kallikrein-1 gene after myocardial infarction' Koch, M.,Spillmann, F.,Dendorfer, A.,Westermann, D.,Altmann, C.,Sahabi, M.,Linthout, S. V.,Bader, M.,Walther, T.,Schultheiss, H. P.,Tschope, C. (2006) 'Cardiac function and remodeling is attenuated in transgenic rats expressing the human kallikrein-1 gene after myocardial infarction'. Eur J Pharmacol, 550 (1-31-3):143-8143 [Details] | |
| (2006) | 'Does the C-type natriuretic peptide have prognostic value in chagas disease and other dilated cardiomyopathies?' Heringer-Walther, S.,Moreira Mda, C.,Wessel, N.,Wang, Y.,Ventura, T. M.,Schultheiss, H. P.,Walther, T. (2006) 'Does the C-type natriuretic peptide have prognostic value in chagas disease and other dilated cardiomyopathies?'. J Cardiovasc Pharmacol, 48 (66):293-8293 [Details] | |
| (2006) | 'A combined technique for predicting pre-eclampsia: concurrent measurement of uterine perfusion and analysis of heart rate and blood pressure variability' Walther, T.,Wessel, N.,Malberg, H.,Voss, A.,Stepan, H.,Faber, R. (2006) 'A combined technique for predicting pre-eclampsia: concurrent measurement of uterine perfusion and analysis of heart rate and blood pressure variability'. J Hypertens, 24 (44):747-50747 [Details] | |
| (2005) | 'Organ-specific distribution of ACE2 mRNA and correlating peptidase activity in rodents' Gembardt, F.,Sterner-Kock, A.,Imboden, H.,Spalteholz, M.,Reibitz, F.,Schultheiss, H. P.,Siems, W. E.,Walther, T. (2005) 'Organ-specific distribution of ACE2 mRNA and correlating peptidase activity in rodents'. Peptides, 26 (77):1270-71270 [Details] | |
| (2005) | 'G-protein-coupled receptor Mas is a physiological antagonist of the angiotensin II type 1 receptor' Kostenis, E.,Milligan, G.,Christopoulos, A.,Sanchez-Ferrer, C. F.,Heringer-Walther, S.,Sexton, P. M.,Gembardt, F.,Kellett, E.,Martini, L.,Vanderheyden, P.,Schultheiss, H. P.,Walther, T. (2005) 'G-protein-coupled receptor Mas is a physiological antagonist of the angiotensin II type 1 receptor'. Circulation, 111 (1414):1806-131806 [Details] | |
| (2005) | 'The endothelium-dependent vasodilator effect of the nonpeptide Ang(1-7) mimic AVE 0991 is abolished in the aorta of mas-knockout mice' Lemos, V. S.,Silva, D. M.,Walther, T.,Alenina, N.,Bader, M.,Santos, R. A. (2005) 'The endothelium-dependent vasodilator effect of the nonpeptide Ang(1-7) mimic AVE 0991 is abolished in the aorta of mas-knockout mice'. J Cardiovasc Pharmacol, 46 (33):274-9274 [Details] | |
| (2005) | 'Central angiotensin II controls alcohol consumption via its AT1 receptor' Maul, B.,Krause, W.,Pankow, K.,Becker, M.,Gembardt, F.,Alenina, N.,Walther, T.,Bader, M.,Siems, W. E. (2005) 'Central angiotensin II controls alcohol consumption via its AT1 receptor'. FASEB J, 19 (1111):1474-811474 [Details] | |
| (2005) | 'Elevated NT-ProBNP levels in patients with increased left ventricular filling pressure during exercise despite preserved systolic function' Tschope, C.,Kasner, M.,Westermann, D.,Walther, T.,Gaub, R.,Poller, W. C.,Schultheiss, H. P. (2005) 'Elevated NT-ProBNP levels in patients with increased left ventricular filling pressure during exercise despite preserved systolic function'. Journal of Cardiac Failure, (11):28-33 [Details] | |
| (2005) | 'Transgenic activation of the kallikrein-kinin system inhibits intramyocardial inflammation, endothelial dysfunction and oxidative stress in experimental diabetic cardiomyopathy' Tschope, C.,Walther, T.,Escher, F.,Spillmann, F.,Du, J.,Altmann, C.,Schimke, I.,Bader, M.,Sanchez-Ferrer, C. F.,Schultheiss, H. P.,Noutsias, M. (2005) 'Transgenic activation of the kallikrein-kinin system inhibits intramyocardial inflammation, endothelial dysfunction and oxidative stress in experimental diabetic cardiomyopathy'. FASEB J, 19 (1414):2057-92057 [Details] | |
| (2005) | 'Angiotensin AT2 receptor deficiency after myocardial infarction: its effects on cardiac function and fibrosis depend on the stimulus' Tschope, C.,Westermann, D.,Dhayat, N.,Dhayat, S.,Altmann, C.,Steendijk, P.,Schultheiss, H. P.,Walther, T. (2005) 'Angiotensin AT2 receptor deficiency after myocardial infarction: its effects on cardiac function and fibrosis depend on the stimulus'. Cell Biochem Biophys, 43 (11):45-5245 [Details] | |
| (2005) | 'Angiotensin II type 1 receptor agonistic antibodies reflect fundamental alterations in the uteroplacental vasculature' Walther, T.,Wallukat, G.,Jank, A.,Bartel, S.,Schultheiss, H. P.,Faber, R.,Stepan, H. (2005) 'Angiotensin II type 1 receptor agonistic antibodies reflect fundamental alterations in the uteroplacental vasculature'. Hypertension, 46 (66):1275-91275 [Details] | |
| (2005) | 'Longitudinal analysis of heart rate variability in chronic hypertensive pregnancy' Walther, T.,Wessel, N.,Baumert, M.,Stepan, H.,Voss, A.,Faber, R. (2005) 'Longitudinal analysis of heart rate variability in chronic hypertensive pregnancy'. Hypertens Res, 28 (22):113-8113 [Details] | |
| (2005) | 'Angiotensin-(1-7) enhances LTP in the hippocampus through the G-protein-coupled receptor Mas' Hellner K, Walther T, Schubert M, Albrecht D (2005) 'Angiotensin-(1-7) enhances LTP in the hippocampus through the G-protein-coupled receptor Mas'. Molecular and cellular neurosciences, 29 (3):427-435 [DOI] [Details] | |
| (2005) | 'Comparison of Heart Rate Variability Obtained from Continuous Blood Pressure Curve and Electrocardiogram' Heringer R, Walther T, Malberg H, Wessel N (2005) 'Comparison of Heart Rate Variability Obtained from Continuous Blood Pressure Curve and Electrocardiogram'. Biomedizinische Technik. Biomedical engineering, (50):1448-1449 [Details] | |
| (2005) | 'Brain natriuretic peptide predicts survival in Chagas' disease more effectively than atrial natriuretic peptide' Heringer-Walther S, Moreira MC, Wessel N, Saliba JL, Silvia-Barra J, Pena JL, Becker S, Siems WE, Schultheiss HP, Walther T (2005) 'Brain natriuretic peptide predicts survival in Chagas' disease more effectively than atrial natriuretic peptide'. Heart (British Cardiac Society), 91 (3):385-387 [DOI] [Details] | |
| (2004) | 'Angiotensin deficiency in mice leads to dilated cardiomyopathy' Walther, T.,Steendijk, P.,Westermann, D.,Hohmann, C.,Schulze, K.,Heringer-Walther, S.,Schultheiss, H. P.,Tschope, C. (2004) 'Angiotensin deficiency in mice leads to dilated cardiomyopathy'. Eur J Pharmacol, 493 (1-31-3):161-5161 [Details] | |
| (2004) | 'Biochemical analysis of neutral endopeptidase activity reveals independent catabolism of atrial and brain natriuretic peptide' Walther, T.,Stepan, H.,Pankow, K.,Becker, M.,Schultheiss, H. P.,Siems, W. E. (2004) 'Biochemical analysis of neutral endopeptidase activity reveals independent catabolism of atrial and brain natriuretic peptide'. Biol Chem, 385 (22):179-84179 [Details] | |
| (2004) | 'Is the MLC1/3 promoter / enhancer the right system to generate skeletal muscle specific animals?' Adams V, Kraenkel N, Kauffold H, Hambrecht R, Schultheiss H, Schuler G, Walther T (2004) 'Is the MLC1/3 promoter / enhancer the right system to generate skeletal muscle specific animals?'. Gene Therapy and Molecular Biology, (8):157-161 [Details] | |
| (2004) | 'Nonpeptide AVE 0991 is an angiotensin-(1-7) receptor Mas agonist in the mouse kidney' Pinheiro, S. V.,Simoes e Silva, A. C.,Sampaio, W. O.,de Paula, R. D.,Mendes, E. P.,Bontempo, E. D.,Pesquero, J. B.,Walther, T.,Alenina, N.,Bader, M.,Bleich, M.,Santos, R. A. (2004) 'Nonpeptide AVE 0991 is an angiotensin-(1-7) receptor Mas agonist in the mouse kidney'. Hypertension, 44 (44):490-6490 [Details] | |
| (2004) | 'Analysis of blood pressure waveform: a new method for the classification of hypertensive pregnancy disorders' Faber R, Stepan H, Baumert M, Voss A, Walther T (2004) 'Analysis of blood pressure waveform: a new method for the classification of hypertensive pregnancy disorders'. Journal of human hypertension, 18 (2):135-137 [DOI] [Details] | |
| (2004) | 'Changes of blood pressure and heart rate variability precede a grand mal seizure in a pregnant woman' Faber, R.,Stepan, H.,Baumert, M.,Voss, A.,Walther, T. (2004) 'Changes of blood pressure and heart rate variability precede a grand mal seizure in a pregnant woman'. J Perinat Med, 32 (66):538-40538 [Details] | |
| (2004) | 'Prevention of cardiac fibrosis and left ventricular dysfunction in diabetic cardiomyopathy in rats by transgenic expression of the human tissue kallikrein gene' Tschope, C.,Walther, T.,Koniger, J.,Spillmann, F.,Westermann, D.,Escher, F.,Pauschinger, M.,Pesquero, J. B.,Bader, M.,Schultheiss, H. P.,Noutsias, M. (2004) 'Prevention of cardiac fibrosis and left ventricular dysfunction in diabetic cardiomyopathy in rats by transgenic expression of the human tissue kallikrein gene'. FASEB J, 18 (77):828-35828 [Details] | |
| (2004) | 'Heart rate turbulence: higher predictive value than other risk stratifiers?' Wessel, N.,Malberg, H.,Walther, T. (2004) 'Heart rate turbulence: higher predictive value than other risk stratifiers?'. Circulation, 109 (99) [Details] | |
| (2004) | 'C-type natriuretic peptide in reproduction, pregnancy and fetal development' Walther T, Stepan H (2004) 'C-type natriuretic peptide in reproduction, pregnancy and fetal development'. The Journal of Endocrinology, 180 (1):17-22 [Details] | |
| (2004) | 'Relation of ANP and BNP to their N-terminal fragments in fetal circulation: evidence for enhanced neutral endopeptidase activity and resistance of BNP to neutral endopeptidase in the fetus' Walther, T.,Stepan, H.,Pankow, K.,Gembardt, F.,Faber, R.,Schultheiss, H. P.,Siems, W. E. (2004) 'Relation of ANP and BNP to their N-terminal fragments in fetal circulation: evidence for enhanced neutral endopeptidase activity and resistance of BNP to neutral endopeptidase in the fetus'. BJOG, 111 (55):452-5452 [Details] | |
| (2004) | 'The bradykinin B1 receptor contributes to the cardioprotective effects of AT1 blockade after experimental myocardial infarction' Tschope, C.,Spillmann, F.,Altmann, C.,Koch, M.,Westermann, D.,Dhayat, N.,Dhayat, S.,Bascands, J. L.,Gera, L.,Hoffmann, S.,Schultheiss, H. P.,Walther, T. (2004) 'The bradykinin B1 receptor contributes to the cardioprotective effects of AT1 blockade after experimental myocardial infarction'. Cardiovasc Res, 61 (33):559-69559 [Details] | |
| (2004) | 'Improvement of defective sarcoplasmic reticulum Ca2+ transport in diabetic heart of transgenic rats expressing the human kallikrein-1 gene' Tschope, C.,Spillmann, F.,Rehfeld, U.,Koch, M.,Westermann, D.,Altmann, C.,Dendorfer, A.,Walther, T.,Bader, M.,Paul, M.,Schultheiss, H. P.,Vetter, R. (2004) 'Improvement of defective sarcoplasmic reticulum Ca2+ transport in diabetic heart of transgenic rats expressing the human kallikrein-1 gene'. FASEB J, 18 (1515):1967-91967 [Details] | |
| (2004) | 'Pre-eclampsia as a 'three stage problem'--a workshop report' Stepan H, Faber R, Froster UG, Heinritz W, Wallaschofski H, Dechend R, Walther T, Huppertz B (2004) 'Pre-eclampsia as a 'three stage problem'--a workshop report'. Placenta, 25 (6):585-587 [Details] | |
| (2003) | 'Differential regulation of in vivo angiogenesis by angiotensin II receptors' Walther, T.,Menrad, A.,Orzechowski, H. D.,Siemeister, G.,Paul, M.,Schirner, M. (2003) 'Differential regulation of in vivo angiogenesis by angiotensin II receptors'. FASEB J, 17 (1414):2061-72061 [Details] | |
| (2003) | 'Fibrosis rather than blood pressure determines cardiac BNP expression in mice' Walther, T.,Klostermann, K.,Heringer-Walther, S.,Schultheiss, H. P.,Tschope, C.,Stepan, H. (2003) 'Fibrosis rather than blood pressure determines cardiac BNP expression in mice'. Regul Pept, 116 (1-31-3):95-10095 [Details] | |
| (2003) | 'Brain natriuretic peptide as a predictor of cardiomyopathy in Chagas' disease' Walther, T.,Heringer-Walther, S.,Wessel, N.,Schultheiss, H. P.,Moreira Mda, C. (2003) 'Brain natriuretic peptide as a predictor of cardiomyopathy in Chagas' disease'. Lancet, 361 (93689368) [Details] | |
| (2003) | 'Transgenic rat model of Huntington's disease' von Horsten, S.,Schmitt, I.,Nguyen, H. P.,Holzmann, C.,Schmidt, T.,Walther, T.,Bader, M.,Pabst, R.,Kobbe, P.,Krotova, J.,Stiller, D.,Kask, A.,Vaarmann, A.,Rathke-Hartlieb, S.,Schulz, J. B.,Grasshoff, U.,Bauer, I.,Vieira-Saecker, A. M.,Paul, M.,Jones, L.,Lindenberg, K. S.,Landwehrmeyer, B.,Bauer, A.,Li, X. J.,Riess, O. (2003) 'Transgenic rat model of Huntington's disease'. Hum Mol Genet, 12 (66):617-24617 [Details] | |
| (2003) | 'Structure and regulation of the murine Mash2 gene' Stepan, H.,Marqwardt, W.,Kuhn, Y.,Hockel, M.,Schultheiss, H. P.,Walther, T. (2003) 'Structure and regulation of the murine Mash2 gene'. Biol Reprod, 68 (11):40-440 [Details] | |
| (2003) | 'Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas' Santos, R. A.,Simoes e Silva, A. C.,Maric, C.,Silva, D. M.,Machado, R. P.,de Buhr, I.,Heringer-Walther, S.,Pinheiro, S. V.,Lopes, M. T.,Bader, M.,Mendes, E. P.,Lemos, V. S.,Campagnole-Santos, M. J.,Schultheiss, H. P.,Speth, R.,Walther, T. (2003) 'Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas'. Proc Natl Acad Sci U S A, 100 (1414):8258-638258 [Details] | |
| (2003) | 'Angiotensin II and the amygdala' Albrecht D, Hellner K, Walther T, von Bohlen und Halbach O (2003) 'Angiotensin II and the amygdala'. Annals of The New York Academy of Sciences, (985):498-500 [Details] | |
| (2003) | 'Effects of kinins on mammalian spermatozoa and the impact of peptidolytic enzymes' Walther T, Rothe L, Winkler A, Siems WE, Maul B, Wiesner B, Becker M (2003) 'Effects of kinins on mammalian spermatozoa and the impact of peptidolytic enzymes'. Andrologia, 35 (1):44-54 [Details] | |
| (2002) | 'Ischemic injury in experimental stroke depends on angiotensin II' Walther, T.,Olah, L.,Harms, C.,Maul, B.,Bader, M.,Hortnagl, H.,Schultheiss, H. P.,Mies, G. (2002) 'Ischemic injury in experimental stroke depends on angiotensin II'. FASEB J, 16 (22):169-76169 [Details] | |
| (2002) | 'AT1 receptor blockade increases cardiac bradykinin via neutral endopeptidase after induction of myocardial infarction in rats' Walther T, Siems WE, Hauke D, Spillmann F, Dendorfer A, Krause W, Schultheiss HP, Tschope C. (2002) 'AT1 receptor blockade increases cardiac bradykinin via neutral endopeptidase after induction of myocardial infarction in rats'. Faseb Journal, 16 (1010):1237-411237 [Details] | |
| (2002) | 'Expression of C-type natriuretic peptide in human placenta and myometrium in normal pregnancies and pregnancies complicated by intrauterine growth retardation. Preliminary results' Stepan, H.,Faber, R.,Stegemann, S.,Schultheiss, H. P.,Walther, T. (2002) 'Expression of C-type natriuretic peptide in human placenta and myometrium in normal pregnancies and pregnancies complicated by intrauterine growth retardation. Preliminary results'. Fetal Diagn Ther, 17 (11):37-4137 [Details] | |
| (2002) | 'Regulation of cardiac bradykinin B1- and B2-receptor mRNA in experimental ischemic, diabetic, and pressure-overload-induced cardiomyopathy' Spillmann, F.,Altmann, C.,Scheeler, M.,Barbosa, M.,Westermann, D.,Schultheiss, H. P.,Walther, T.,Tschope, C. (2002) 'Regulation of cardiac bradykinin B1- and B2-receptor mRNA in experimental ischemic, diabetic, and pressure-overload-induced cardiomyopathy'. Int Immunopharmacol, 2 (13-1413-14):1823-321823 [Details] | |
| (2002) | 'Reduced hypertension-induced end-organ damage in mice lacking cardiac and renal angiotensinogen synthesis' Kang, N.,Walther, T.,Tian, X. L.,Bohlender, J.,Fukamizu, A.,Ganten, D.,Bader, M. (2002) 'Reduced hypertension-induced end-organ damage in mice lacking cardiac and renal angiotensinogen synthesis'. J Mol Med (Berl), 80 (66):359-66359 [Details] | |
| (2002) | 'Cell type-specific expression of the Mas proto-oncogene in testis' Alenina N, Baranova T, Smirnow E, Bader M, Lippoldt A, Patkin E, Walther T. (2002) 'Cell type-specific expression of the Mas proto-oncogene in testis'. Journal of Histochemistry & Cytochemistry, 50 (55):691-6691 [Details] | |
| (2002) | 'Fetal, neonatal cord, and maternal plasma concentrations of angiotensin-converting enzyme (ACE)' Walther T, Faber R, Maul B, Schultheiss HP, Siems WE, Stepan H. (2002) 'Fetal, neonatal cord, and maternal plasma concentrations of angiotensin-converting enzyme (ACE)'. Prenatal diagnosis, 22 (2):111-113 [Details] | |
| (2002) | 'Multiple interactions between the renin-angiotensin and the kallikrein-kinin systems: role of ACE inhibition and AT1 receptor blockade' Tschope, C.,Schultheiss, H. P.,Walther, T. (2002) 'Multiple interactions between the renin-angiotensin and the kallikrein-kinin systems: role of ACE inhibition and AT1 receptor blockade'. J Cardiovasc Pharmacol, 39 (44):478-87478 [Details] | |
| (2002) | 'Natriuretic peptide system in fetal heart and circulation' Walther, T.,Schultheiss, H. P.,Tschope, C.,Stepan, H. (2002) 'Natriuretic peptide system in fetal heart and circulation'. J Hypertens, 20 (55):785-91785 [Details] | |
| (2002) | 'Joint symbolic dynamic analysis of beat-to-beat interactions of heart rate and systolic blood pressure in normal pregnancy' Baumert M, Walther T, Hopfe J, Stepan H, Faber R, Voss A. (2002) 'Joint symbolic dynamic analysis of beat-to-beat interactions of heart rate and systolic blood pressure in normal pregnancy'. Medical & Biological Engineering & Computing, 40 (2):241-245 [Details] | |
| (2002) | 'Imprinting of the murine MAS protooncogene is restricted to its antisense RNA' Alenina, N.,Bader, M.,Walther, T. (2002) 'Imprinting of the murine MAS protooncogene is restricted to its antisense RNA'. Biochem Biophys Res Commun, 290 (33):1072-81072 [Details] | |
| (2001) | 'Alcohol consumption is controlled by angiotensin II' Maul B, Siems WE, Hoehe MR, Grecksch G, Bader M, Walther T. (2001) 'Alcohol consumption is controlled by angiotensin II'. The Faseb Journal, 15 (9):1640-1642 [Details] | |
| (2001) | 'Baroreflex improvement in shr after ace inhibition involves angiotensin-(1-7)' Heringer-Walther S, Batista EN, Walther T, Khosla MC, Santos RA, Campagnole-Santos MJ. (2001) 'Baroreflex improvement in shr after ace inhibition involves angiotensin-(1-7)'. Hypertension, 37 (5):1309-1314 [Details] | |
| (2001) | 'Dual natriuretic peptide response to volume load in the fetal circulation' Walther T, Stepan H, Faber R. (2001) 'Dual natriuretic peptide response to volume load in the fetal circulation'. Cardiovascular research, 49 (4):817-819 [Details] | |
| (2001) | 'Left ventricular function in mice lacking the AT2 receptor' Gross V, Walther T, Milia AF, Walter K, Schneider W, Luft FC. (2001) 'Left ventricular function in mice lacking the AT2 receptor'. Journal of hypertension, 19 (5):967-976 [Details] | |
| (2001) | 'Genetic deletion of angiotensin AT2 receptor leads to increased cell numbers in different brain structures of mice' von Bohlen und Halbach O, Walther T, Bader M, Albrecht D. (2001) 'Genetic deletion of angiotensin AT2 receptor leads to increased cell numbers in different brain structures of mice'. Regulatory peptides, 99 (2-3):209-216 [Details] | |
| (2001) | 'Impaired angiotensin II regulation of renal C-type natriuretic peptide mRNA expression in experimental diabetes mellitus' Walther T, Schuitheiss HP, Tschöpe C. (2001) 'Impaired angiotensin II regulation of renal C-type natriuretic peptide mRNA expression in experimental diabetes mellitus'. Cardiovascular research, 51 (3):562-566 [Details] | |
| (2001) | 'Gestational regulation of the gene expression of C-type natriuretic peptide in mouse reproductive and embryonic tissue' Stepan H, Leitner E, Walter K, Bader M, Schultheiss H, Faber R, Walther T. (2001) 'Gestational regulation of the gene expression of C-type natriuretic peptide in mouse reproductive and embryonic tissue'. Regulatory peptides, 102 (1):9-13 [Details] | |
| (2000) | 'Interaction between Mas and the angiotensin AT1 receptor in the amygdala' Von Bohlen und Halbach O, Walther T, Bader M, Albrecht D. (2000) 'Interaction between Mas and the angiotensin AT1 receptor in the amygdala'. Journal of neurophysiology, 83 (4):2012-2021 [Details] | |
| (2000) | 'Organ-specific mRNA distribution of C-type natriuretic peptide in neonatal and adult mice' Stepan H, Leitner E, Bader M, Walther T. (2000) 'Organ-specific mRNA distribution of C-type natriuretic peptide in neonatal and adult mice'. Regulatory peptides, 95 (1-3):81-85 [Details] | |
| (2000) | 'Hypoalgesia and altered inflammatory responses in mice lacking kinin B1 receptors' Pesquero JB, Araujo RC, Heppenstall PA, Stucky CL, Silva JA Jr, Walther T, Oliveira SM, Pesquero JL, Paiva AC, Calixto JB, Lewin GR, Bader M. (2000) 'Hypoalgesia and altered inflammatory responses in mice lacking kinin B1 receptors'. Proceedings of The National Academy of Sciences of The United States of America, 97 (14):8140-8145 [DOI] [Details] | |
| (2000) | 'Regulation of the kinin receptors after induction of myocardial infarction: a mini-review' Tschöpe C, Heringer-Walther S, Walther T. (2000) 'Regulation of the kinin receptors after induction of myocardial infarction: a mini-review'. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas / Sociedade Brasileira de Biofisica ... [et al.], 33 (6):701-708 [Details] | |
| (2000) | 'Upregulation of bradykinin B1-receptor expression after myocardial infarction' Tschöpe C, Heringer-Walther S, Koch M, Spillmann F, Wendorf M, Leitner E, Schultheiss HP, Walther T. (2000) 'Upregulation of bradykinin B1-receptor expression after myocardial infarction'. British journal of pharmacology, 129 (8):1537-1538 [DOI] [Details] | |
| (2000) | 'Baroreflex sensitivity, heart rate, and blood pressure variability in normal pregnancy' Voss A, Malberg H, Schumann A, Wessel N, Walther T, Stepan H, Faber R. (2000) 'Baroreflex sensitivity, heart rate, and blood pressure variability in normal pregnancy'. American journal of hypertension, 13 (11):1218-1225 [Details] | |
| (2000) | 'Detection of C-type natriuretic peptide in fetal circulation' Stepan H, Walther D, Faber R, Walther T. (2000) 'Detection of C-type natriuretic peptide in fetal circulation'. Journal of perinatal medicine, 28 (2):118-121 [DOI] [Details] | |
| (2000) | 'Opposite regulation of brain and C-type natriuretic peptides in the streptozotocin-diabetic cardiopathy' Walther T, Heringer-Walther S, Tschöpe R, Reinecke A, Schultheiss HP, Tschöpe C. (2000) 'Opposite regulation of brain and C-type natriuretic peptides in the streptozotocin-diabetic cardiopathy'. Journal of molecular endocrinology, 24 (3):391-395 [Details] | |
| (2000) | 'Sex specific behavioural alterations in Mas-deficient mice' Walther T, Voigt JP, Fink H, Bader M. (2000) 'Sex specific behavioural alterations in Mas-deficient mice'. Behavioural Brain Research, 107 (1-2):105-109 [Details] | |
| (2000) | 'Inhibition of pressure natriuresis in mice lacking the AT2 receptor' Gross V, Schunck WH, Honeck H, Milia AF, Kärgel E, Walther T, Bader M, Inagami T, Schneider W, Luft FC. (2000) 'Inhibition of pressure natriuresis in mice lacking the AT2 receptor'. Kidney international, 57 (1):191-202 [DOI] [Details] | |
| (2000) | 'Altered heart rate and blood pressure variability in mice lacking the Mas protooncogene' Walther T, Wessel N, Kang N, Sander A, Tschöpe C, Malberg H, Bader M, Voss A. (2000) 'Altered heart rate and blood pressure variability in mice lacking the Mas protooncogene'. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas / Sociedade Brasileira de Biofisica ... [et al.], 33 (1):1-9 [Details] | |
| (2000) | 'Myocardial bradykinin B2-receptor expression at different time points after induction of myocardial infarction' Tschöpe C, Heringer-Walther S, Koch M, Spillmann F, Wendorf M, Hauke D, Bader M, Schultheiss HP, Walther T. (2000) 'Myocardial bradykinin B2-receptor expression at different time points after induction of myocardial infarction'. Journal of hypertension, 18 (2):223-228 [Details] | |
| (2000) | 'Smooth-muscle contraction without smooth-muscle myosin' Morano I, Chai GX, Baltas LG, Lamounier-Zepter V, Lutsch G, Lutsch G, Kott M, Haase H, Walther T, Bader M. (2000) 'Smooth-muscle contraction without smooth-muscle myosin'. Nature Cell Biology, (2) [Details] | |
| (1999) | 'Larger anastomoses in angiotensinogen-knockout mice attenuate early metabolic disturbances after middle cerebral artery occlusion' Maeda K, Hata R, Bader M, Walther T, Hossmann KA. (1999) 'Larger anastomoses in angiotensinogen-knockout mice attenuate early metabolic disturbances after middle cerebral artery occlusion'. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 19 (10):1092-1098 [DOI] [Details] | |
| (1999) | 'C-type natriuretic peptide levels in women with gestational hypertension and preeclampsia' Stepan H, Faber R, Walther D, Walther T. (1999) 'C-type natriuretic peptide levels in women with gestational hypertension and preeclampsia'. Obstetrics & Gynaecology, 93 (2):199-202 [Details] | |
| (1999) | 'mRNA quantification of C-type natriuretic peptide in brain areas of rodents' Stepan H, Leitner E, Siems WE, Maul B, Walther T. (1999) 'mRNA quantification of C-type natriuretic peptide in brain areas of rodents'. Peptides, 20 (10):1243-1245 [Details] | |
| (1999) | 'Learning and anxiety in angiotensin-deficient mice' Walther T, Voigt JP, Fukamizu A, Fink H, Bader M. (1999) 'Learning and anxiety in angiotensin-deficient mice'. Behavioural Brain Research, 100 (1-2):1-4 [Details] | |
| (1999) | 'Myocardial expression of rat bradykinin receptors and two tissue kallikrein genes in experimental diabetes' Tschöpe C, Walther T, Yu M, Reinecke A, Koch M, Seligmann C, Heringer SB, Pesquero JB, Bader M, Schultheiss H, Unger T. (1999) 'Myocardial expression of rat bradykinin receptors and two tissue kallikrein genes in experimental diabetes'. Immunopharmacology, 44 (1-2):35-42 [Details] | |
| (1999) | 'Upregulation of the cardiac bradykinin B2 receptors after myocardial infarction' Tschöpe C, Koch M, Spillmann F, Heringer-Walther S, Mochmann HC, Stauss H, Bader M, Unger T, Schultheiss HP, Walther T. (1999) 'Upregulation of the cardiac bradykinin B2 receptors after myocardial infarction'. Immunopharmacology, 44 (1-2):111-117 [Details] | |
| (1999) | 'Gender specific alterations of heart rate and blood pressure variability in Mas-deficient mice' Wather T, Wessel N, Kang N, Sander A, Malberg H, Bader M, Voss A. (1999) 'Gender specific alterations of heart rate and blood pressure variability in Mas-deficient mice'. Journal of Clinical and Basic Cardiology, (2):281-282 [Details] | |
| (1999) | 'Expression of low density lipoprotein receptor messenger ribonucleic acid in placentas from pregnancies with intrauterine growth retardation' Stepan H, Faber R, Walther T. (1999) 'Expression of low density lipoprotein receptor messenger ribonucleic acid in placentas from pregnancies with intrauterine growth retardation'. British journal of obstetrics and gynaecology, 106 (11):1221-1222 [Details] | |
| (1998) | 'DNA analysis for phospholipase A2 coding sequences of Mycoplasma hominis isolated from women with a normal pregnancy and women with a pregnancy complicated by preterm labour' Stepan H, Faber R, Retzlaff C, Walther T. (1998) 'DNA analysis for phospholipase A2 coding sequences of Mycoplasma hominis isolated from women with a normal pregnancy and women with a pregnancy complicated by preterm labour'. Archives of gynecology and obstetrics, 261 (4):189-191 [Details] | |
| (1998) | 'C-type natriuretic peptide in maternal plasma in spontaneous labour, at elective cesarean section and during puerperium' Stepan H, Walther T, Faber R. (1998) 'C-type natriuretic peptide in maternal plasma in spontaneous labour, at elective cesarean section and during puerperium'. Journal of perinatal medicine, 26 (5):396-399 [Details] | |
| (1998) | 'Absence of phospholipase A2 activity in genital Mycoplasma hominis' Walther T, Stepan H, Baumann L, Walther D, Faber R. (1998) 'Absence of phospholipase A2 activity in genital Mycoplasma hominis'. Journal of perinatal medicine, 26 (3):208-210 [Details] | |
| (1998) | 'A simple technique to isolate DNA and supernatant of genital Mycoplasma hominis and Ureaplasma urealyticum' Walther T, Retzlaff C, Stepan H, Faber R. (1998) 'A simple technique to isolate DNA and supernatant of genital Mycoplasma hominis and Ureaplasma urealyticum'. Journal of perinatal medicine, 26 (2):123-124 [Details] | |
| (1998) | 'Sustained long term potentiation and anxiety in mice lacking the Mas protooncogene' Walther T, Balschun D, Voigt JP, Fink H, Zuschratter W, Birchmeier C, Ganten D, Bader M. (1998) 'Sustained long term potentiation and anxiety in mice lacking the Mas protooncogene'. Journal of Biological Chemistry, 273 (19):11867-11873 [Details] | |
| (1998) | 'Detection of C-type natriuretic peptide in normal pregnancy' Stepan H, Walther T, Walther D, Faber R. (1998) 'Detection of C-type natriuretic peptide in normal pregnancy'. Journal of perinatal medicine, 26 (1):56-58 [Details] |
Abstract
| Year | Publication | |
|---|---|---|
| (2013) | Identification of Intracellular Signaling Pathways in Human Endothelial Cells Stimulated by Angiotensin-(1-7). Meinert, C,Gembardt, F,Greenberg, B,Walther, T (2013) Identification of Intracellular Signaling Pathways in Human Endothelial Cells Stimulated by Angiotensin-(1-7). Abstract [Details] |
Reviews
| Year | Publication | |
|---|---|---|
| (2017) | Gender differences in the effects of cardiovascular drugs. Tamargo, J;Rosano, G;Walther, T;Duarte, J;Niessner, A;Kaski, JC;Ceconi, C;Drexel, H;Kjeldsen, K;Savarese, G;Torp-Pedersen, C;Atar, D;Lewis, BS;Agewall, S (2017) Gender differences in the effects of cardiovascular drugs. OXFORD: Reviews [DOI] [Details] | |
| (2014) | Sphingosine-1-Phosphate as a Potential Target for the Treatment of Myocardial Infarction. Waeber, C,Walther, T (2014) Sphingosine-1-Phosphate as a Potential Target for the Treatment of Myocardial Infarction. Reviews [DOI] [Details] |
Professional Activities
Honours and Awards
| Year | Title | Awarding Body | |
|---|---|---|---|
| 2000 | Young Investigator Award | Deutsche Bluthochdruckliga | |
| 2008 | The Professors’ Prize 2008 | Association for Clinical Biochemistry | |
| 1998 | Schmiedeberg-Preis | Deutsche Gesellschaft für Experimentelle und Klinische Pharmakologie und Toxikologie | |
| 2001 | Young Investigator Award | European Society Heart Failure | |
| 2001 | Research Prize 2001 | Medical Faculty, Freie Universität, Berlin | |
| 1997 | Promotionspreis | Deutsche Gesellschaft für Genetik |
Professional Associations
| Association | Function | From / To | |
|---|---|---|---|
| International Society for the Study of Hypertension in Pregnancy (ISSHP) | member | 01-JAN-04 / | |
| German Society of Cardiology | member | 01-JAN-99 / | |
| Journal Hypertension in Pregnancy | editoral board member | 03-JAN-11 / | |
| Scientific Advisory Board ‘Solvay AG’, Hannover, Germany | member | 01-JAN-03 / 30-DEC-10 | |
| ‘German High Blood Pressure League’ student fellowships, program evaluation annual meetings | member and reviewer | / 01-FEB-02 | |
| International Society for Heart Research (ISHR) | member | 01-JAN-10 / | |
| European Heart Failure Association (EHFA) | member | 01-JAN-02 / | |
| Working Group on Cardiovascular Pharmacology and Drug Therapy in the European Society of Cardiology | nucleus member | 01-MAY-14 / | |
| German Society of Prenatal Medicine | board member | 01-JAN-07 / | |
| ‘Ironwood’, USA | scientific advisor | 02-JAN-12 / | |
| ‘Tarix Pharmaceuticals LTD’, USA | scientific advisor | 03-JAN-11 / | |
| American Heart Association (AHA) | member | 02-JAN-00 / |
Education
| Year | Institution | Qualification | Subject | |
|---|---|---|---|---|
| 1997 | Free University Berlin, Germany | PhD | Molecular Medicine | |
| 1997 | Free University Berlin, German | PhD | Chemistry | |
| 1994 | University Halle-Wittenberg, Germany | MSc | Biology |
Other Activities
| Description | |
|---|---|
Expertise: Cardiovascular physiology, animal models of diseases of civilisation, molecular pharmacology, cell biology, protein analysis, cellular signalling, peptide systems, obesity, cardiovascular diseases, neuro-degenerative diseases, acoustic manipulation of cells and tissues. |
Contact details
- Thomas Walther
Head of Department - t.walther@ucc.ie
- Western Gateway Building
University College Cork
Co. Cork, Ireland - 353 (0)21 420 5973
- 353 (0)21 420 5471