Department of Physiology funding (Oct 2014 - ).
Investigation into the potential of GLP-1 mimetics for treatment of functional bowel disorders. PhD student: Rebecca O'Brien (co-supervised with Prof. K O'Halloran).
Health Research Board Investigator Led Project (2018-2021)
Biography
Dervla O’Malley received a first class BSc (Hons) degree in Biomedical Sciences from the University of Ulster, Coleraine. As part of this degree she spent 13 months in the University of Nevada, Reno for which she was awarded a Diploma in industrial studies with commendation. She carried out her doctoral studies at the University of Dundee, Scotland, having received a Muir Russell Scholarship and subsequently undertook a post-doctoral fellowship in the University of Cambridge, England followed by a post-doctoral position in the University of Edinburgh..
She returned to Ireland in 2007 and spent 4 years as a senior postdoctoral scientist in the Laboratory of Neurogastroenterology, in APC Microbiome Ireland in University College Cork. In December 2011 she joined the Department of Physiology as a lecturer and Principal Investigator. She has taught students from Physiology, Medicine, Medicine and Health Sciences and Dentistry neurophysiology and gastrointestinal physiology. Recently ('22/23), she has taken the lead on developing and establishing an MSc Clinical Physiology, and in collaboration with clinical colleagues will train post-graduate students as Clinical Measurement Physiologists.
The theme of Dervla’s research is neuroimmune and neuroendocrine interactions in the gastrointestinal tract and the central nervous system. Of particular relevance to her group is immune and endocrine factors in gastrointestinal dysfunction in disorders such as irritable bowel syndrome (IBS). This work fits with her tole as a funded investigator in APC Microbiome Ireland. Her group is also investigating cognitive aspects of Duchenne Muscular Dystrophy.
Dervla has published more than fifty peer-reviewed manuscripts, four book chapters and over 100 conference publications. She has a H-index of 26 and i10 index of 42. She is is a member of the editorial board for 'The Journal of Physiology', 'Physiology News', 'Neurogastroenterology and Motility', 'World Journal of Gastroenterology', ‘Frontiers in Neuroscience, Physiology & Neurology’ and 'American Journal of Physiology, Gastrointestinal and Liver Physiology'. She is also an invited reviewer for over thirty journals in the fields of physiology, gastroenterology and neuroscience.
Research Interests
Current Projects:
Investigation into the potential of GLP-1 mimetics for treatment of functional bowel disorders. PhD student: Rebecca O'Brien (co-supervised with Prof. K O'Halloran).
Health Research Board Investigator Led Project (2018-2021)
Monoclonal xIL-6R antibodies as a treatment for memory dysfunction in the mdx mouse model of Duchenne Muscular Dystrophy. PhD student: Kimberley Stepheson (co-supervised by Dr M.Rae).
Chinese Government Scholarships (March 2021 - March 2025).
‘NeuroBiota’: Understanding the mechanisms of cross-barrier communication between gut microbiota and the host nervous system in health and disease.
PhD student: Qiao Xiao (co-supervised by Dr S. Joyce).
Research Grants
| Project | Funding Body | Start Date | End Date | Award | |
|---|---|---|---|---|---|
| Is the obesity hormone leptin protective against the pro-secretory effects of interleukin-6 in the colon? | UCC Strategic Research Fund | 01-JUL-14 | 31-AUG-14 | €2,000.00 | |
| Monoclonal xIL-6R Antibodies as a Treatment for Memory Dysfunction in the mdx Mouse Model of Duchenne Muscular Dystrophy. | Health Research Board | 01-OCT-17 | 30-JUN-21 | €158,285.00 | |
| Elecrophysiological Investigations on th molecular mechanisms underlying gut-to-brain signalling evoked by colonic microbiota. | Foreign Research Institute | 01-AUG-15 | 31-AUG-17 | €121,376.00 | |
| WellcomeTr"109296/Z/15/Z SS Conor Slattery"Dr D O'Malley | Foreign Research Institute | 02-JUN-15 | 27-JUL-15 | €2,743.00 | |
| Does ghrelin sensitise colonic myenteric neurons to the stimulatory effects of Glucagon-like peptide-1? | Other: Not Listed | 01-JAN-16 | 31-DEC-16 | €9,500.00 | |
| To determine if changes in inflammatory sttus in respiratory muscules contribute to loss of respiratory muscle function in mdx mice. | Irish Funded Research Non Exchequer | 01-APR-14 | 31-MAR-15 | €10,000.00 | |
| Leptine IL-6 crosstalk. | Foreign Research Institute | 01-JAN-13 | 31-JUL-14 | €11,319.00 | |
| Does crosstalk between corticotropin-releasing factor and interleukin-6 underlie skeletal and smaooth muscle inflammation and dysfunction in the mdx mouse model of Duchenne Muscular Dystrophy. | Irish Charities | 01-JAN-13 | 31-MAR-14 | €10,000.00 | |
| Equipment | UCC Strategic Research Fund | 01-JUN-13 | 01-AUG-13 | €6,500.00 | |
| Studies to investigate crosstalk between Interleukin-6 and Glucagon-Like Peptide-1 and their influence of the pathophysiology of Irritable Bowel Syndrome. | 01-JUN-12 | 01-JUN-13 | €9,960.00 | ||
| Studies to investigate the role of Glucagon-Like Peptide-1 in the post-prandial exacerbation of Irritable Bowel Syndrome symtoms. | Health Research Board | 02-JUL-12 | 24-AUG-12 | €2,000.00 | |
| Does post-prandial secretion of Glucagon-like-peptide 1 exacerbate the gastrointestinal symptoms of Irritable Bowel Syndrome? | UCC Strategic Research Fund | 01-JUN-12 | 01-AUG-12 | €2,000.00 | |
| Electrophysiology Equipment | UCC Strategic Research Fund | 01-JUN-12 | 01-AUG-12 | €10,000.00 | |
| HRB HRA_POR/2010/52 | Health Research Board | 01-DEC-11 | 01-DEC-12 | €70,125.00 | |
| Equipment Repair | UCC Strategic Research Fund | 14-NOV-14 | 30-NOV-14 | €3,285.56 |
Publications
Book Chapters
| Year | Publication | |
|---|---|---|
| (2018) | 'Interleukin-6 Modulates Colonic Transepithelial Ion Transport in the Stress-Sensitive Wistar Kyoto Rat. Frontiers Research Topics: Novel insights which may translate into treatments for Irritable Bowel Syndrome' Dervla O’Malley, Timothy G. Dinan and John F. Cryan (2018) 'Interleukin-6 Modulates Colonic Transepithelial Ion Transport in the Stress-Sensitive Wistar Kyoto Rat. Frontiers Research Topics: Novel insights which may translate into treatments for Irritable Bowel Syndrome' In: Topic Editor: Angel A.Izzo (eds). Novel insights into irritable bowel syndrome pharmacology. http://frontiersin.org/books/b/260: Frontiers ebook. [Details] | |
| (2015) | 'Convergence of Neuro-Endocrine-Immune Pathways in the Pathophysiology of Irritable Bowel Syndrome' Buckley M, O’Mahony SM and O’Malley D (2015) 'Convergence of Neuro-Endocrine-Immune Pathways in the Pathophysiology of Irritable Bowel Syndrome' In: Advances in Irritable Bowel Syndrome. California, USA: Baishideng Publishing Group. [Details] | |
| (2011) | 'Crosstalk Between the Stress and Immune Factors Contribute to the Pathophysiology of Irritable Bowel Syndrome' O'Malley, D (2011) 'Crosstalk Between the Stress and Immune Factors Contribute to the Pathophysiology of Irritable Bowel Syndrome' In: Advances in Medicine and Biology. Volume 23. New York, USA: Nova Publishers. [Details] |
Peer Reviewed Journals
| Year | Publication | |
|---|---|---|
| (2022) | 'Bile acids, bioactive signalling molecules in interoceptive gut-to-brain communication' Joyce, Susan A.;O'Malley, Dervla (2022) 'Bile acids, bioactive signalling molecules in interoceptive gut-to-brain communication'. Journal of Physiology-London, [DOI] [Full Text] [Details] | |
| (2021) | 'Divergent effects of exendin-4 and interleukin-6 on rat colonic secretory and contractile activity are associated with changes in regional vagal afferent signaling' O'Brien, R;Buckley, MM;O'Malley, D (2021) 'Divergent effects of exendin-4 and interleukin-6 on rat colonic secretory and contractile activity are associated with changes in regional vagal afferent signaling'. Neurogastroenterology and Motility, 33 [DOI] [Details] | |
| (2021) | 'Aberrant Gut-To-Brain Signaling in Irritable Bowel Syndrome - The Role of Bile Acids' Ní Dhonnabháín R;Xiao Q;O'Malley D; (2021) 'Aberrant Gut-To-Brain Signaling in Irritable Bowel Syndrome - The Role of Bile Acids'. Frontiers In Endocrinology, 12 [DOI] [Details] | |
| (2020) | 'Mucosal Tuft Cell Density Is Increased in Diarrhea-Predominant Irritable Bowel Syndrome Colonic Biopsies' Aigbologa J.;Connolly M.;Buckley J.M.;O'Malley D. (2020) 'Mucosal Tuft Cell Density Is Increased in Diarrhea-Predominant Irritable Bowel Syndrome Colonic Biopsies'. Frontiers in psychiatry, 11 [DOI] [Details] | |
| (2020) | 'Glucagon-Like Peptide-1 Secreting L-Cells Coupled to Sensory Nerves Translate Microbial Signals to the Host Rat Nervous System' Buckley M.M.;O’Brien R.;Brosnan E.;Ross R.P.;Stanton C.;Buckley J.M.;O’Malley D. (2020) 'Glucagon-Like Peptide-1 Secreting L-Cells Coupled to Sensory Nerves Translate Microbial Signals to the Host Rat Nervous System'. Frontiers in Cellular Neuroscience, 14 [DOI] [Details] | |
| (2019) | 'The Glucagon-like peptide-1 receptor agonist, exendin-4, ameliorated gastrointestinal dysfunction in the Wistar Kyoto rat model of Irritable Bowel Syndrome' O’Brien, Rebecca; O’Malley, Dervla (2019) 'The Glucagon-like peptide-1 receptor agonist, exendin-4, ameliorated gastrointestinal dysfunction in the Wistar Kyoto rat model of Irritable Bowel Syndrome'. Neurogastroenterology and Motility, [DOI] [Full Text] [Details] | |
| (2019) | 'GHSR-1 agonist sensitizes rat colonic intrinsic and extrinsic neurons to exendin-4: A role in the manifestation of postprandial gastrointestinal symptoms in irritable bowel syndrome?' Buckley, Maria M.; O'Brien, Rebecca; Buckley, Julliette M.; O'Malley, Dervla (2019) 'GHSR-1 agonist sensitizes rat colonic intrinsic and extrinsic neurons to exendin-4: A role in the manifestation of postprandial gastrointestinal symptoms in irritable bowel syndrome?'. Neurogastroenterology and Motility, :1-13 [DOI] [Full Text] [Details] | |
| (2019) | 'How much do preclinical medical students utilize the internet to study physiology?' O'Malley D.;Barry D.;Rae M. (2019) 'How much do preclinical medical students utilize the internet to study physiology?'. Advances in Physiology Education, 43 (3):383-391 [DOI] [Details] | |
| (2019) | 'Heparan sulphate and hylauronic acid components of the glycocalyx do not play a role in flow mediated dilation of the iliac in the anaesthetized pig' Ruane-O'Hora T;O'Malley D;Buckley MM;Markos F; (2019) 'Heparan sulphate and hylauronic acid components of the glycocalyx do not play a role in flow mediated dilation of the iliac in the anaesthetized pig'. Canadian Journal of Physiology and Pharmacology, [DOI] [Details] | |
| (2019) | 'PI 3-kinase- and ERK-MAPK-dependent mechanisms underlie Glucagon-Like Peptide-1-mediated activation of Sprague Dawley colonic myenteric neurons' O'Brien, Rebecca; Buckley, Maria M.; Kelliher, Amy; O'Malley, Dervla (2019) 'PI 3-kinase- and ERK-MAPK-dependent mechanisms underlie Glucagon-Like Peptide-1-mediated activation of Sprague Dawley colonic myenteric neurons'. Neurogastroenterology and Motility, :1-11 [DOI] [Full Text] [Details] | |
| (2019) | 'Bacterial modulation of visceral sensation: mediators and mechanisms' Lomax, Alan E.; Pradhananga, Sabindra; Sessenwein, Jessica L.; O'Malley, Dervla (2019) 'Bacterial modulation of visceral sensation: mediators and mechanisms'. American Journal Of Physiology-Gastrointestinal And Liver Physiology, [DOI] [Full Text] [Details] | |
| (2018) | 'Recovery of respiratory function in mdx mice co-treated with neutralizing interleukin-6 receptor antibodies and urocortin-2' Burns DP, Canavan L, Rowland J, O'Flaherty R, Brannock M, Drummond SE, O'Malley D, Edge D, O'Halloran KD (2018) 'Recovery of respiratory function in mdx mice co-treated with neutralizing interleukin-6 receptor antibodies and urocortin-2'. The Journal of Physiology, 596 (21) [DOI] [Details] | |
| (2018) | 'Endocrine regulation of gut function – a role for glucagon-like peptide-1 in the pathophysiology of irritable bowel syndrome' O'Malley, Dervla (2018) 'Endocrine regulation of gut function – a role for glucagon-like peptide-1 in the pathophysiology of irritable bowel syndrome'. Experimental Physiology, 104 (1):3-10 [DOI] [Full Text] [Details] | |
| (2017) | 'Restoration of pharyngeal dilator muscle force in dystrophin-deficient (mdx) mice following co-treatment with neutralizing interleukin-6 receptor antibodies and urocortin 2' Burns DP, Rowland J, Canavan L, Murphy KH, Brannock M, O'Malley D, O'Halloran KD, Edge D (2017) 'Restoration of pharyngeal dilator muscle force in dystrophin-deficient (mdx) mice following co-treatment with neutralizing interleukin-6 receptor antibodies and urocortin 2'. Experimental Physiology, 102 (9) [DOI] [Details] | |
| (2017) | 'Using an online student response system, Socrative, to facilitate active learning of Physiology by first year graduate entry to medicine students: a feasibility study' Rae, M.G and O'Malley, D. (2017) 'Using an online student response system, Socrative, to facilitate active learning of Physiology by first year graduate entry to medicine students: a feasibility study'. MedEdPublish, 6 (1) [DOI] [Full Text] [Details] | |
| (2017) | 'Student attitudes towards semi-flipped classroom teaching in a pre-clinical graduate entry to medicine Physiology module' Rae, M.G and O'Malley, D. (2017) 'Student attitudes towards semi-flipped classroom teaching in a pre-clinical graduate entry to medicine Physiology module'. MedEdPublish, [Full Text] [Details] | |
| (2017) | 'Combined xIL-6R and urocortin-2 treatment restores mdx diaphragm muscle force' Manning J, Buckley MM, O'Halloran KD, O'Malley D (2017) 'Combined xIL-6R and urocortin-2 treatment restores mdx diaphragm muscle force'. Muscle & Nerve, :1-7 [DOI] [Full Text] [Details] | |
| (2017) | 'Restoration of pharyngeal dilator muscle force in dystrophin-deficient (mdx) mice following co-treatment with neutralizing interleukin-6 receptor antibodies and urocortin-2' Burns, David P.; Rowland, Jane; Canavan, Leonie; Murphy, Kevin H.; Brannock, Molly; O'Malley, Dervla; O'Halloran, Ken D.; Edge, Deirdre (2017) 'Restoration of pharyngeal dilator muscle force in dystrophin-deficient (mdx) mice following co-treatment with neutralizing interleukin-6 receptor antibodies and urocortin-2'. Experimental Physiology, 102 (9):1177-1193 [DOI] [Full Text] [Details] | |
| (2016) | 'Do prerecorded lecture VODcasts affect lecture attendance of first-year pre-clinical Graduate Entry to Medicine students?' Rae, M.G. & O'Malley, D. (2016) 'Do prerecorded lecture VODcasts affect lecture attendance of first-year pre-clinical Graduate Entry to Medicine students?'. Medical Teacher, [DOI] [Full Text] [Details] | |
| (2016) | 'Leptin modifies the prosecretory and prokinetic effects of the inflammatory cytokine interleukin-6 on colonic function in Sprague–Dawley rats' Buckley, Maria M.; O'Brien, Rebecca; Devlin, Michelle; Creed, Aisling A.; Rae, Mark G.; Hyland, Niall P.; Quigley, Eamonn M. M.; McKernan, Declan P.; O'Malley, Dervla (2016) 'Leptin modifies the prosecretory and prokinetic effects of the inflammatory cytokine interleukin-6 on colonic function in Sprague–Dawley rats'. Experimental Physiology, 101 (12):1477-1491 [DOI] [Full Text] [Details] | |
| (2016) | 'Neuroimmune Cross Talk in the Gut. Neuroendocrine and neuroimmune pathways contribute to the pathophysiology of irritable bowel syndrome' O'Malley, Dervla (2016) 'Neuroimmune Cross Talk in the Gut. Neuroendocrine and neuroimmune pathways contribute to the pathophysiology of irritable bowel syndrome'. American Journal of Physiology - Gastrointestinal and Liver Physiology, 311 (5):G934-G941 [DOI] [Full Text] [Details] | |
| (2016) | 'Cognitive dysfunction in Duchenne Muscular Dystrophy: a possible role for neuromodulatory immune molecules' Rae MG;O'Malley D; (2016) 'Cognitive dysfunction in Duchenne Muscular Dystrophy: a possible role for neuromodulatory immune molecules'. Journal of neurophysiology, [DOI] [Full Text] [Details] | |
| (2016) | 'In vivo neutralisation of IL-6 receptors ameliorates gastrointestinal dysfunction in dystrophin-deficient mdx mice' Manning J, Buckley MM, O'Halloran KD, O'Malley D (2016) 'In vivo neutralisation of IL-6 receptors ameliorates gastrointestinal dysfunction in dystrophin-deficient mdx mice'. Neurogastroenterology and Motility, 28 (7):1016-1026 [Details] | |
| (2015) | 'Respiratory control in the mdx mouse model of Duchenne muscular dystrophy' Burns DP, Edge D, O'Malley D, O'Halloran KD (2015) 'Respiratory control in the mdx mouse model of Duchenne muscular dystrophy'. Advances In Experimental Medicine and Biology, 860 :239-244 [Details] | |
| (2015) | 'Early-life stress selectively affects gastrointestinal but not behavioral responses in a genetic model of brain-gut axis dysfunction' Hyland NP, O'Mahony SM, O'Malley D, O'Mahony CM, Dinan TG, Cryan JF (2015) 'Early-life stress selectively affects gastrointestinal but not behavioral responses in a genetic model of brain-gut axis dysfunction'. Neurogastroenterology and Motility, 27 (1):105-113 [Details] | |
| (2015) | 'Immunomodulation of enteric neural function in irritable bowel syndrome' O'Malley D. (2015) 'Immunomodulation of enteric neural function in irritable bowel syndrome'. World Journal of Gastroenterology, 21 (24):7362-7366 [DOI] [Details] | |
| (2015) | 'IBS plasma sensitises colonic submucosal neurons to glp-1-evoked activation' O'Brien, R,Buckley, M,O'Malley, D (2015) 'IBS plasma sensitises colonic submucosal neurons to glp-1-evoked activation'. Neurogastroenterology and Motility, 27 :112-112 [Details] | |
| (2015) | 'Immunomodulation of enteric neural function in Irritable Bowel Syndrome' Dervla O'Malley (2015) 'Immunomodulation of enteric neural function in Irritable Bowel Syndrome'. World Journal of Gastroenterology, [Details] | |
| (2015) | 'What has the mdx mouse contributed to our understanding of Duchenne Muscular Dystrophy?' Jennifer Manning and Dervla O'Malley (2015) 'What has the mdx mouse contributed to our understanding of Duchenne Muscular Dystrophy?'. Journal of Muscle Research and Cell Motility, [Details] | |
| (2015) | 'Respiratory Control in the mdx Mouse Model of Duchenne Muscular Dystrophy' Burns DP;Edge D;O'Malley D;O'Halloran KD; (2015) 'Respiratory Control in the mdx Mouse Model of Duchenne Muscular Dystrophy'. Advances In Experimental Medicine and Biology, 860 [DOI] [Details] | |
| (2014) | 'Convergence of neuro-endocrine-immune pathways in the pathophysiology of irritable bowel syndrome' Buckley, MM;O'Mahony, SM;O'Malley, D (2014) 'Convergence of neuro-endocrine-immune pathways in the pathophysiology of irritable bowel syndrome'. World Journal of Gastroenterology, 20 :8846-8858 [DOI] [Details] | |
| (2014) | 'Differential visceral pain sensitivity and colonic morphology in four common laboratory rat strains' O'Malley D, Julio-Pieper M, O'Mahony SM, Dinan TG, Cryan JF (2014) 'Differential visceral pain sensitivity and colonic morphology in four common laboratory rat strains'. Experimental physiology, 99 (2):359-367 [DOI] [Details] | |
| (2014) | 'Soluble mediators in plasma from irritable bowel syndrome patients excite rat submucosal neurons' O'Malley D, Buckley MM, McKernan DP, Quigley EM, Cryan JF, Dinan TG (2014) 'Soluble mediators in plasma from irritable bowel syndrome patients excite rat submucosal neurons'. Brain Behav Immun, [DOI] [Details] | |
| (2014) | 'Modulation of enteric neurons by Interleukin‐6 and CRF contributes to visceral hypersensitivity and altered colonic motility in a rat model of Irritable Bowel Syndrome' Buckley MM, O'Halloran KD, Rae MG, Dinan TG, and O'Malley D (2014) 'Modulation of enteric neurons by Interleukin‐6 and CRF contributes to visceral hypersensitivity and altered colonic motility in a rat model of Irritable Bowel Syndrome'. Journal of Physiology, 592 :5235-5250 [Details] | |
| (2014) | 'Strain differences in stress-induced changes in central CRF1 receptor expression' O’Malley D, Julio-Pieper M, Dinan TG & Cryan JF (2014) 'Strain differences in stress-induced changes in central CRF1 receptor expression'. Neuroscience Letters, 21 (561):192-197 [Details] | |
| (2014) | 'Amitriptyline is efficacious in ameliorating muscle inflammation and depressive symptoms in the mdx mouse model of Duchenne muscular dystrophy' Manning, J;Kulbida, R;Rai, P;Jensen, L;Bouma, J;Singh, SP;O'Malley, D;Yilmazer-Hanke, D (2014) 'Amitriptyline is efficacious in ameliorating muscle inflammation and depressive symptoms in the mdx mouse model of Duchenne muscular dystrophy'. Experimental Physiology, 99 :1370-1386 [DOI] [Details] | |
| (2013) | 'Crosstalk between interleukin-6 and corticotropin-releasing factor modulate submucosal plexus activity and colonic secretion' O'Malley D, Cryan JF, Dinan TG (2013) 'Crosstalk between interleukin-6 and corticotropin-releasing factor modulate submucosal plexus activity and colonic secretion'. Brain Behav Immun, doi:pii: S0889-1591(13)00081-0. 10.1016/j.bbi.2013.01.078. [Epub ahead of print] [Details] | |
| (2012) | 'Interleukin-6 modulates transepithelial ion transport in Wistar Kyoto rat distal colon' O’Malley D, Dinan TG & Cryan JF (2012) 'Interleukin-6 modulates transepithelial ion transport in Wistar Kyoto rat distal colon'. Frontiers In Pharmacology, [Details] | |
| (2011) | 'Colonic soluble mediators from the maternal separation model of irritable bowel syndrome activate submucosal neurons via an interleukin-6-dependent mechanism' O'Malley, D;Liston, M;Hyland, NP;Dinan, TG;Cryan, JF (2011) 'Colonic soluble mediators from the maternal separation model of irritable bowel syndrome activate submucosal neurons via an interleukin-6-dependent mechanism'. American Journal of Physiology - Gastrointestinal and Liver Physiology, 300 :241-252 [DOI] [Details] | |
| (2011) | 'Neonatal maternal separation in the rat impacts on the stress responsivity of central corticotropin-releasing factor receptors in adulthood' O'Malley, D;Dinan, TG;Cryan, JF (2011) 'Neonatal maternal separation in the rat impacts on the stress responsivity of central corticotropin-releasing factor receptors in adulthood'. Journal of Psychopharmacology, 214 :221-229 [DOI] [Details] | |
| (2011) | 'Do interactions between stress and immune responses lead to symptom exacerbations in irritable bowel syndrome?' O'Malley D, Quigley EM, Dinan TG, Cryan JF (2011) 'Do interactions between stress and immune responses lead to symptom exacerbations in irritable bowel syndrome?'. Brain Behav Immun, 25 (7):1333-1341 [DOI] [Details] | |
| (2011) | 'Altered expression and secretion of colonic interleukin-6 in a stress-sensitive animal model of brain-gut axis dysfunction' O'Malley D, Dinan TG, Cryan JF (2011) 'Altered expression and secretion of colonic interleukin-6 in a stress-sensitive animal model of brain-gut axis dysfunction'. Journal of Neuroimmunology, 235 (1-2):48-55 [DOI] [Details] | |
| (2010) | 'Differential stress-induced alterations of colonic corticotropin-releasing factor receptors in the Wistar Kyoto rat' O'Malley, D; Julio-Pieper, M; Gibney, SM; Gosselin, RD; Dinan, TG; Cryan, JF; (2010) 'Differential stress-induced alterations of colonic corticotropin-releasing factor receptors in the Wistar Kyoto rat'. Neurogastroenterology and Motility, 22 :301-311 [DOI] [Details] | |
| (2010) | 'Alterations in colonic corticotropin-releasing factor receptors in the maternally separated rat model of irritable bowel syndrome: Differential effects of acute psychological and physical stressors' O'Malley, D; Dinan, TG; Cryan, JF; (2010) 'Alterations in colonic corticotropin-releasing factor receptors in the maternally separated rat model of irritable bowel syndrome: Differential effects of acute psychological and physical stressors'. Peptides, 31 :662-670 [DOI] [Details] | |
| (2010) | 'Distinct alterations in colonic morphology and physiology in two rat models of enhanced stress-induced anxiety and depression-like behaviour' O'Malley D, Julio-Pieper M, Gibney SM, Dinan TG, Cryan JF; (2010) 'Distinct alterations in colonic morphology and physiology in two rat models of enhanced stress-induced anxiety and depression-like behaviour'. Stress (Amsterdam, Netherlands), 13 (2):114-122 [DOI] [Details] | |
| (2009) | 'Region specific decrease in glial fibrillary acidic protein immunoreactivity in the brain of a rat model of depression' Gosselin RD, Gibney S, O'Malley D, Dinan TG, Cryan JF; (2009) 'Region specific decrease in glial fibrillary acidic protein immunoreactivity in the brain of a rat model of depression'. Neuroscience, 159 (2):915-925 [DOI] [Details] | |
| (2007) | 'MAPK-dependent actin cytoskeletal reorganization underlies BK channel activation by insulin' O'Malley D, Harvey J (2007) 'MAPK-dependent actin cytoskeletal reorganization underlies BK channel activation by insulin'. The European Journal of Neuroscience, 25 (3):673-682 [DOI] [Details] | |
| (2007) | 'Leptin promotes rapid dynamic changes in hippocampal dendritic morphology' O'Malley D, MacDonald N, Mizielinska S, Connolly CN, Irving AJ, Harvey J (2007) 'Leptin promotes rapid dynamic changes in hippocampal dendritic morphology'. Molecular and cellular neurosciences, 35 (4):559-572 [DOI] [Details] | |
| (2006) | 'Sodium-coupled glucose cotransporters contribute to hypothalamic glucose sensing' O'Malley D, Reimann F, Simpson AK, Gribble FM (2006) 'Sodium-coupled glucose cotransporters contribute to hypothalamic glucose sensing'. Diabetes, 55 (12):3381-3386 [DOI] [Details] | |
| (2005) | 'Leptin: a potential cognitive enhancer?' Harvey J, Shanley LJ, O'Malley D, Irving AJ (2005) 'Leptin: a potential cognitive enhancer?'. Biochemical Society Transactions, 33 (Pt 5):1029-1032 [DOI] [Details] | |
| (2005) | 'The neurotransmitters glycine and GABA stimulate glucagon-like peptide-1 release from the GLUTag cell line' Gameiro A, Reimann F, Habib AM, O'Malley D, Williams L, Simpson AK, Gribble FM (2005) 'The neurotransmitters glycine and GABA stimulate glucagon-like peptide-1 release from the GLUTag cell line'. The Journal of Physiology, 569 (Pt 3):761-772 [DOI] [Details] | |
| (2005) | 'Leptin-induced dynamic alterations in the actin cytoskeleton mediate the activation and synaptic clustering of BK channels' O'Malley D, Irving AJ, Harvey J (2005) 'Leptin-induced dynamic alterations in the actin cytoskeleton mediate the activation and synaptic clustering of BK channels'. The Faseb Journal, 19 (13):1917-1919 [DOI] [Details] | |
| (2004) | 'Insulin activates native and recombinant large conductance Ca(2+)-activated potassium channels via a mitogen-activated protein kinase-dependent process' O'Malley D, Harvey J (2004) 'Insulin activates native and recombinant large conductance Ca(2+)-activated potassium channels via a mitogen-activated protein kinase-dependent process'. Molecular Pharmacology, 65 (6):1352-1363 [DOI] [Details] | |
| (2003) | 'Insulin inhibits rat hippocampal neurones via activation of ATP-sensitive K+ and large conductance Ca2+-activated K+ channels' O'Malley D, Shanley LJ, Harvey J (2003) 'Insulin inhibits rat hippocampal neurones via activation of ATP-sensitive K+ and large conductance Ca2+-activated K+ channels'. Pharmacology, 44 (7):855-863 [Details] | |
| (2002) | 'Leptin inhibits epileptiform-like activity in rat hippocampal neurones via PI 3-kinase-driven activation of BK channels' Shanley LJ, O'Malley D, Irving AJ, Ashford ML, Harvey J (2002) 'Leptin inhibits epileptiform-like activity in rat hippocampal neurones via PI 3-kinase-driven activation of BK channels'. The Journal of Physiology, 545 (Pt 3):933-944 [Details] |
Conference Publications
| Year | Publication | |
|---|---|---|
| (2018) | Europhysiology, London D O’Malley and MG Rae. (2018) How much do pre-clinical medical students utilise the internet to study Physiology? Europhysiology, London [Details] | |
| (2018) | Europhysiology, London M. Connolly, J. Aigbologa, R. O’Brien, M.M Buckley, J.M Buckley and D. O’Malley. (2018) Tuft cell hyperplasia in diarrhoea-predominant Irritable Bowel Syndrome colonic biopsies Europhysiology, London [Details] | |
| (2018) | Europhysiology, London K.A. Stephenson, C. Shanahan, M.G. Rae and D. O’Malley. (2018) Synaptic expression of interleukin-6 receptors and dystrophin may indicate a role in cognitive deficits associated with loss of dystrophin Europhysiology, London [Details] | |
| (2017) | ESNM Poster Presentation M.M. Buckley; G. O’Driscoll; C. Stanton and D. O’Malley. (2017) Vagal nerve activity is increased by GABA-secreting probiotics in the distal colon ESNM Poster Presentation [Details] | |
| (2017) | ESNM Poster Presentation 17. E. Brosnan; M.M. Buckley; C. Stanton and D. O’Malley. (2017) L-cells are key to cross-barrier signalling to the host peripheral nervous system by GLP-1 secreting probiotics ESNM Poster Presentation [Details] | |
| (2017) | EB2017 DP Burns, L Canavan, J Rowland, R O’Flaherty, D. O’Malley, D Edge, KD O’Halloran. (2017) Targeting IL-6 and CRFR2 Improves Diaphragm Muscle Function and Restores Ventilation in Mdx Mice EB2017 [Details] | |
| (2017) | ESNM Oral Presentation M.M Buckley; A.C. Leahy; C. Stanton and D. O’Malley. (2017) Bifidobacterium Breve NCFB 2258 stimulates vagal nerve firing across an intact colonic barrier ESNM Oral Presentation [Details] | |
| (2016) | FNM M.M. Buckley and D O’Malley. (2016) Immune and Stress Factors in the Distal colon alter Vagal Nerve Activity FNM San Francisco, US, [Details] | |
| (2016) | The Bacterial Metabolite Indole alters vagal neve activity M.M. Buckley, C, Slattery and D O’Malley. (2016) Physiological Society / IUPS The Bacterial Metabolite Indole alters vagal neve activity Dublin, [Details] | |
| (2016) | A GLP-1 mimetic alleviates Irritable Bowel Syndrome-like symptoms in the Wistar Kyoto rat R. O’Brien, M. Buckley, K.D. O’Halloran, D. O’Malley. (2016) EB2016 A GLP-1 mimetic alleviates Irritable Bowel Syndrome-like symptoms in the Wistar Kyoto rat San Diego, UA, [Details] | |
| (2016) | Ghrelin does not sensitise colonic myenteric neurons to GLP-1 in Sprague Dawley rats 31. R O’Brien, K Barry Murphy and D O’Malley. (2016) Oral presentation. Shortlisted for Donegan medal Ghrelin does not sensitise colonic myenteric neurons to GLP-1 in Sprague Dawley rats RAMI Cork, [Details] | |
| (2016) | Ghrelin as a novel regulator of glucagon-like peptide 1-evoked activation of myenteric neurons R. O’Brien, K. Barry Murphy, and D O’Malley. (2016) Physiological Society / IUPS Ghrelin as a novel regulator of glucagon-like peptide 1-evoked activation of myenteric neurons Dublin, Ireland, [Details] | |
| (2016) | The bacterial metabolite indole, signals to the CNS using L-cells to activated vagal nerve activity MM Buckley, C Slattery and D O’Malley. (2016) Oral presentation. Shortlisted for Donegan medal The bacterial metabolite indole, signals to the CNS using L-cells to activated vagal nerve activity RAMI Cork, [Details] | |
| (2015) | Experimental Biology (Boston, USA) Burns DP, Manning J, O'Malley D, O'Halloran KD (2015) Respiratory function in the mdx mouse model of Duchenne muscular dystrophy: role of hypoxia, stress and immune factors Experimental Biology (Boston, USA) [Details] | |
| (2015) | Royal Academy of Medicine in Ireland Sectíon of Biomedical Sciences Annual Meeting Ali I, Burns D, Lewis P, O'Malley D, O'Halloran KD (2015) THE SUPEROXIDE SCAVENGER TEMPOL DOES NOT IMPROVE DIAPHRAGM MUSCLE WEAKNESS IN THE MDX MOUSE MODEL OF DUCHENNE MUSCULAR DYSTROPHY Royal Academy of Medicine in Ireland Sectíon of Biomedical Sciences Annual Meeting [Details] | |
| (2014) | Federation of Neurogastroenterology and Motility Buckley, MM,O'Malley, D (2014) Interleukin-6 and corticotropin-releasing factor contribute to visceral pain and colonic transit in the Wistar Kyoto rat model of Irritable Bowel Syndrome Federation of Neurogastroenterology and Motility [Details] | |
| (2014) | Oxford Conference on the Control of Breathing (Sydney, Australia) Burns D, O'Leary AJ, O'Malley D, O'Halloran KD (2014) Effects of acute sustained hypoxic stress on sternohyoid and diaphragm muscle function in the mdx mouse model of Duchenne muscular dystrophy Oxford Conference on the Control of Breathing (Sydney, Australia) [Details] | |
| (2014) | Little Brain Big Brain Buckley, MM,O'Malley, D (2014) Interleukin-6 and corticotropin-releasing factor contribute to visceral pain and colonic transit in the Wistar Kyoto rat model of Irritable Bowel Syndrome Little Brain Big Brain [Details] | |
| (2014) | The Oxford Breathing Meeting 2. D. Burns, A. O’ Leary, D. O’Malley, K.D. O’ Halloran. (2014) Effects of acute hypoxic stress on sternohyoid and diaphragm muscle function in the Mdx mouse model of Duchenne muscular dystrophy The Oxford Breathing Meeting [Details] | |
| (2014) | Physiological Society - Obesity meeting Buckley, MM, Devlin M, Blake A, O'Malley, D (2014) Crosstalk between leptin and interleukin-6 in the pathophysiology of Irritable Bowel Syndrome Physiological Society - Obesity meeting [Details] | |
| (2014) | RAMI Buckley, MM,O'Malley, D (2014) Changes in colonic mucosal protein expression underlies the therapeutic benefits of anti-IL-6R and antalarmin on IBS-like symptoms in the WKY rat RAMI [Details] | |
| (2014) | Physiological Society Buckley, MM,O'Malley, D (2014) Immune and Stress factors alter colonic contractile activity Physiological Society [Details] | |
| (2014) | The Oxford Breathing Meeting 1. I. Ali, D. Burns, D. O’Malley, K.D. O’Halloran. (2014) The superoxide scavenger Tempol does not improve diaphragm muscle weakness in the mdx mouse model of Duchenne muscular dystrophy The Oxford Breathing Meeting [Details] | |
| (2013) | Irish Journal of Medical Science Buckley, MM,O'Malley, D (2013) Rat myenteric neurons are activated by immune factors in irritable bowel syndrome plasma Irish Journal of Medical Science , pp.121-121 [Details] | |
| (2013) | Dietary Disease Week Buckley, M and O’Malley, D. (2013) Inhibition of Interleukin-6 signalling suppresses visceral pain sensitivity and stress-induced defecation in the Wistar Kyoto rat model of IBS Dietary Disease Week [Details] | |
| (2013) | RAMI Kelliher A, O’Sullivan L, Buckley M and O’Malley D. (2013) Crosstalk between GLP-1 and IL-6 in isolated rat myenteric and submucosal neurons RAMI [Details] | |
| (2013) | IUPS Manning J and O’Malley D. (2013) The role of interleukin-6 in gastrointestinal contractile activity in the mdx mouse model of Duchenne Muscular Dystrophy IUPS [Details] | |
| (2013) | RAMI Buckley MM and O’Malley D. (2013) Visceral pain sensitivity and stress-induced defecation in the Wistar Kyoto rat model of IBS is suppressed by inhibition of interleukin-6 signalling RAMI [Details] | |
| (2013) | RAMI Manning J and O’Malley D. (2013) Gastrointestinal contractile activity in the mdx mouse model of Duchenne muscular dystrophy, a role for il-6 in pathophysiology RAMI [Details] | |
| (2012) | Neurogastroenterology and Motility O'Malley, D,Quigley, E,Cryan, J,Dinan, T (2012) Up-regulation of IL-6-expressing macrophages in human colonic mucosal biopsies Neurogastroenterology and Motility , pp.66-66 [Details] | |
| (2012) | Neurogastroenterology & Motility Buckley M & O’Malley D (2012) Immune factors in irritable bowel syndrome plasma activate rat myenteric neurons Neurogastroenterology & Motility Neurogastroenterology and Motility, , 06-SEP-12 - 09-SEP-12 [Details] | |
| (2011) | DDW 2011; Gastroenterology Moloney, G.,Fanning, A.,O'Malley, D.,Scanlan, N.,Cryan, J. F.,Dinan, T. G.,Shanahan, F.,Quigley, E. M.,Melgar, S.,Nally, K. (2011) Stimulation of T-Cells in Irritable Bowel Syndrome (IBS) Mucosal Biopsy Tissue Releases Cytokines Which Selectively Activate Submucosal Neurons DDW 2011; Gastroenterology [Details] | |
| (2012) | Neurogastroenterology & Motility Buckley, M,Dinan, TG,O'Malley, D (2012) Immune factors in Irritable Bowel Syndrome plasma activate rat myenteric neurons Neurogastroenterology & Motility , pp.64-64 [Details] | |
| (2012) | Neurogastroenterology & Motility O’Malley, D; Quigley, EM; Cryan, JF; Dinan, TG. (2012) Up-regulation of il-6-expressing macrophages in human colonic mucosal biopsies Neurogastroenterology & Motility Neurogastroenterology and Motility, , 06-SEP-12 - 09-SEP-12 [Details] | |
| (2011) | DDW, Chicago Moloney G, Fanning A, O’ Malley D, Scanlan N, Melgar S, Nally K (2011) An Altered Immune Profile in IBS Patients? DDW, Chicago [Details] | |
| (2011) | DDW, Chicago O’Malley, D; Quigley, EM; Cryan, JF; Dinan, TG (2011) Plasma derived from patients with irritable bowel syndrome excites rat submucosal neurons via IL-6 and CRFR1 dependent mechanisms DDW, Chicago [Details] | |
| (2010) | Neurogastroenterology & Motility, Boston O’Malley, D; Cryan, JF; Dinan, TG. (2010) Corticotropin-Releasing Factor Sensitizes Rat Sub-Mucosal Neurons to the Effects of IL-6 Neurogastroenterology & Motility, Boston [Details] | |
| (2010) | Translational Health Research Conference, UCC, Cork O’Malley, D; Liston, M; Dinan, TG; Cryan, JF; Hyland, NP (2010) CRF1 receptor-dependent activation of submucosal neurones by colonic supernatants from maternally separated rats Translational Health Research Conference, UCC, Cork [Details] | |
| (2010) | PNIRS, Dublin O’Malley, D; Cryan, JF; Dinan, TG (2010) Corticotropin-Releasing Factor-mediated enhancement of Interleukin-6-induced activation of Sub-Mucosal Neurons PNIRS, Dublin [Details] | |
| (2010) | DDW, New Orleans O’Malley, D; Liston, M; Dinan, TG; Cryan, JF; Hyland, NP. (2010) CRF1 receptor-dependent activation of submucosal neurones by colonic supernatants from maternally separated rats DDW, New Orleans [Details] | |
| (2009) | Neurogastroenterology & Motility, Chicago O’Malley, D; Dinan, TG and Cryan, JF. (2009) IL-6 activates neurons of the sub-mucosal plexus via a MAPK-dependent mechanism: relevance to irritable bowel syndrome Neurogastroenterology & Motility, Chicago [Details] | |
| (2009) | Irish Society for Gastroenterology, Killarney O’Malley, D; Dinan, TG and Cryan, JF (2009) IL-6 activates neurons in the sub-mucosal plexus via a MAPK-dependent mechanism Irish Society for Gastroenterology, Killarney [Details] | |
| (2009) | Translational Health Research Conference, UCC, Cork O’Malley, D; Dinan, TG and Cryan, JF (2009) IL-6 activates neurons in the sub-mucosal plexus via a MAPK-dependent mechanism Translational Health Research Conference, UCC, Cork [Details] | |
| (2009) | Translational Health Research Conference, UCC, Cork O’Malley, D, Julio-Pieper, M, Dinan, TG and Cryan, JF (2009) Colo-rectal distension induces changes in expression of CRF receptors in the CNS of Wistar Kyoto rats Translational Health Research Conference, UCC, Cork [Details] | |
| (2008) | Neurogastroenterology & Motility, Lucerne O’Malley, D, Julio-Pieper, M, Gosselin, RD, Dinan, TG and Cryan, JF (2008) Changes in the expression of CRF receptors in the brain and colon following Colo-rectal distension Neurogastroenterology & Motility, Lucerne [Details] | |
| (2008) | Second Joint International Meeting for Neurogastroenterology and Motility, Lucerne, Switzerland, November 2008 Hyland, NP, O’ Callaghan K, O’Malley, D, Lee, K, Dinan, TG, Cryan, JF (2008) Differential cholinergic sensitivity in the enteric nervous system in two models of visceral hypersensitivity Second Joint International Meeting for Neurogastroenterology and Motility, Lucerne, Switzerland, November 2008 [Details] | |
| (2008) | Neuroscience Ireland, Galway O’Malley, D: Julio-Pieper, M; Dinan, T.G. and Cryan, J.F. (2008) Colo-rectal distension induces changes in expression of CRF receptors in the CNS of WKY rats Neuroscience Ireland, Galway [Details] | |
| (2008) | Eur. Behav. Pharm. Soc, Cork Gosselin, RD; Gibney, SM; O’Malley, D; Dinan, TG and Cryan, JF (2008) Region specific decrease in glial fibrillary acidic protein (GFAP) immunoreactivity in the brain of a genetic rat model of depression Eur. Behav. Pharm. Soc, Cork [Details] | |
| (2008) | Neurogastroenterology & Motility, Lucerne O’Malley, D, Julio-Pieper, M; Dinan, TG and Cryan, JF (2008) The effects of stress on colonic morphology in two animal models of Irritable Bowel Syndrome Neurogastroenterology & Motility, Lucerne [Details] | |
| (2008) | Neurogastroenterology & Motility, Lucerne Gibney SM, Gosselin RD, O'Malley, D, Dinan TG and Cryan JF (2008) Altered Colonic Rectal Distension-induced activation of the prefrontal cortex in two animal models of Irritable Bowel Syndrome Neurogastroenterology & Motility, Lucerne [Details] | |
| (2008) | Irish Society Gastroenterology, Sligo Gibney, SM; Gosselin, RD; O’Malley, D; Dinan, TG and Cryan, JF (2008) Imaging distinct patterns of cortical brain activation following Colorectal Distension in an animal model of irritable bowel syndrome Irish Society Gastroenterology, Sligo [Details] | |
| (2007) | Society for Neuroscience Gosselin RD, O'Mahony S, Gibney S, Fitzgerald P, O’Malley D, Dinan TG and Cryan JF. (2007) Altered spinal glial activation in genetically anxious Wistar Kyoto rats: implications for visceral pain in irritable bowel syndrome (IBS) Society for Neuroscience [Details] | |
| (2007) | Society for Neuroscience Gibney SM, Gosselin RD, Fitzgerald P, O’Malley D, Dinan TG and Cryan JF. (2007) Genetic influence on stress- and colonic rectal distension-induced alterations in brain activation: Implications for the pathophysiology of irritable bowel syndrome Society for Neuroscience [Details] | |
| (2007) | Irish Society of Gastroenterology, Dublin 20. O’Malley, D, Hyland, N, Julio-Pieper, M, Gosselin, R, Gibney, S, O’Mahony, S, Dinan, TG and Cryan, JF (2007) Early life stress alters colonic CRF1 and CRF2 receptor expression in the rat Irish Society of Gastroenterology, Dublin [Details] | |
| (2006) | Diabetes UK O’Malley, D and Gribble, FM (2006) The role of sodium/glucose co-transporters in glucose-sensing by glucose-excited neurons in the hypothalamus Diabetes UK [Details] | |
| (2006) | IGIS, Nice, France O’Malley, D Simpson, AK and Gribble FM (2006) Glucose-sensing in glucose-excited hypothalamic neurons utilise sodium/glucose co-transporters IGIS, Nice, France [Details] | |
| (2004) | Society for Neuroscience Solovyova, N, O’Malley, D, Lambert, JJ and Harvey, J (2004) Leptin modulates fast inhibitory synaptic transmission in the hippocampus Society for Neuroscience [Details] | |
| (2003) | Society for Neuroscience O’Malley, D, Irving, AJ, and Harvey, J (2003) Leptin induces internalisation of leptin receptors in hippocampal neurons Society for Neuroscience [Details] | |
| (2003) | Physiological Society O’Malley, D, Ashford, MLJ and Harvey, J (2003) Insulin activates human large conductance Ca2+ -activated K+ (BK) channels via a PI 3-kinase independent pathway Physiological Society [Details] | |
| (2003) | BNA O’Malley, D, Ashford, MLJ. and Harvey, J (2003) PI 3-kinase does not mediate activation of large conductance Ca2+-activated K+ (BK) channels by insulin BNA [Details] |
Abstract
| Year | Publication | |
|---|---|---|
| (2016) | Changes in Colonic Mucosal Protein Expression Underlies the Therapeutic Benefits of Anti-IL-6R and Antalarmin on IBS-Like Symptoms in the Wistar Kyoto Rat. Buckley, MM;O'Malley, D (2016) Changes in Colonic Mucosal Protein Expression Underlies the Therapeutic Benefits of Anti-IL-6R and Antalarmin on IBS-Like Symptoms in the Wistar Kyoto Rat. LONDON: Abstract [Details] | |
| (2016) | Gastrointestinal Contractile Activity in the mdx Mouse Model of Duchenne Muscular Dystrophy, a Role for Il-6 in Pathophysiology. Manning, J;O'Malley, D (2016) Gastrointestinal Contractile Activity in the mdx Mouse Model of Duchenne Muscular Dystrophy, a Role for Il-6 in Pathophysiology. LONDON: Abstract [Details] | |
| (2015) | IBS plasma sensitises colonic submucosal neurons to glp-1-evoked activation. O'Brien, R;Buckley, M;O'Malley, D (2015) IBS plasma sensitises colonic submucosal neurons to glp-1-evoked activation. HOBOKEN: Abstract [Details] | |
| (2015) | Blocking Interleukin-6 signalling ameliorates gastrointestinal dysfunction in the mdx model of Duchenne Muscular Dystrophy. Manning, J;O'Malley, D (2015) Blocking Interleukin-6 signalling ameliorates gastrointestinal dysfunction in the mdx model of Duchenne Muscular Dystrophy. BETHESDA: Abstract [Details] | |
| (2012) | Immune factors in Irritable Bowel Syndrome plasma activate rat myenteric neurons. Buckley, M;Dinan, TG;O'Malley, D (2012) Immune factors in Irritable Bowel Syndrome plasma activate rat myenteric neurons. HOBOKEN: Abstract [Details] | |
| (2008) | Region specific decrease in glial fibrillary acidic protein (GFAP) immunoreactivity in the brain of a genetic rat model of depression. Gosselin, RD;Gibney, S;O'Malley, D;Dinan, TG;Cryan, JF (2008) Region specific decrease in glial fibrillary acidic protein (GFAP) immunoreactivity in the brain of a genetic rat model of depression. PHILADELPHIA: Abstract [Details] |
Book Reviews
| Year | Publication | |
|---|---|---|
| (2019) | Book review: The Heart of the Brain - The hypothalamus and its hormones by Gareth Lang. Dervla O'Malley (2019) Book review: The Heart of the Brain - The hypothalamus and its hormones by Gareth Lang. Book Reviews [Details] |
Editorship
| Year | Publication | |
|---|---|---|
| (2016) | Gastrointestinal Contractile Activity in the mdx Mouse Model of Duchenne Muscular Dystrophy, a Role for Il-6 in Pathophysiology. Manning, J,O'Malley, D (2016) Gastrointestinal Contractile Activity in the mdx Mouse Model of Duchenne Muscular Dystrophy, a Role for Il-6 in Pathophysiology. Editorship [Details] | |
| (2015) | Immunomodulation of enteric neural function in irritable bowel syndrome. O'Malley, D (2015) Immunomodulation of enteric neural function in irritable bowel syndrome. Editorship [DOI] [Details] |
Professional Activities
Honours and Awards
| Year | Title | Awarding Body | |
|---|---|---|---|
| 2017 | Aurora, Women in leadership in Higher Education | Aurora | |
| 2018 | Aurora, Women in leadership in Higher Education | Role model | |
| 2015 | Short-listed for Inaugural Review Prize | Experimental Physiology | |
| 2010 | Young Investigator Award | Neurogastroenterology and Motility | |
| 2009 | 1st prize oral presentation | Irish Society of Gastroenterology | |
| 2001 | Muir Russell PhD Scholarship | University of Dundee |
Professional Associations
| Association | Function | From / To | |
|---|---|---|---|
| APC Microbiome Ireland | Faculty member | 01-JUN-11 / | |
| Physiological Society of UK & Ireland | Member | 01-JAN-02 / | |
| European Society for Neurogastroenterology and Motility | Member | 01-FEB-10 / 28-FEB-18 | |
| America Gastroenterology Association | Member | 01-JAN-07 / |
Committees
| Committee | Function | From / To | |
|---|---|---|---|
| School of Medicine AthenaSwan Self Assessment Team | Member and Chair of Working Group. | 2022 / 2023 | |
| College of Medicine and Health Graduate studies committee, University College Cork. | Board member, School of medicine representative | 2019 / | |
| AthenaSWAN working group on Flexible Working | Member | 2019 / 2019 | |
| Department of Physiology Graduate Studies Committee | Chair and Member | 2012 / | |
| School of Medicine Research and Postgraduate Affairs Committee | Member | 2016 / 2022 | |
| AEEC | Member | 2015 / 2018 | |
| Working Group to establish Paramedic Studies in UCC | member | 2014 / 2016 | |
| Post-graduate Review Comittee | Member | 2012 / | |
| Board of Studies for mPharm committee | member | 2014 / 2015 | |
| Research Quality Review Panel | member | 2014 / 2015 |
Outreach Activities
| Description | |
|---|---|
Interactive presentations on basic physiological processes to primary school children in Cork and Carlow (2007 - 2012). | |
Food, Microbes and Molecular Medicine (APC and UCC), 2014, session chair | |
Reporting of research progress patients and family members of Muscular Dystrophy Ireland at annual meetings (2012 -2015) |
Journal Activities
| Journal | Role | To / From | |
|---|---|---|---|
| Frontiers In Neuroscience | Member of Editorial Board | 04-JAN-21 - | |
| The Journal Of Physiology | Editor | 01-JUL-19 - | |
| Neurogastroenterol & Motility | Editor | 31-JAN-19 - 31-JAN-22 | |
| World Journal Of Gastroenterology | Member of Editorial Board | 01-MAY-13 - 01-MAY-22 | |
| International Journal Of Psychophysiology | Referee | - | |
| European Journal Of Pharmacology | Referee | - | |
| Clinical And Experimental Immunology | Referee | - | |
| Canadian Journal Of Physiology And Pharmacology | Referee | - | |
| Neuropsychopharmacology | Referee | - | |
| Behavioral Brain Research | Referee | - | |
| Regulatory Peptides | Referee | - | |
| American Journal Of Physiology-Gastrointestinal And Liver Physiology | Editor | 01-JUL-21 - | |
| British Journal Of Pharmacology | Referee | - | |
| Molecular Psychiatry | Referee | - |
Other Activities
| Description | |
|---|---|
Invited speaker ('Rising stars'): 'On the constancy of the internal environment - a celebration of Claude Bernard' hosted by UCC, June 2013. | |
FNM 2020, Adelaide, Australia, Chair and invited speaker. Online in 2021 | |
Successful bid for workshop entitled ‘Brain-gut neuroimmune signalling in visceral pain’ at 13th Congress of the European Pain Federation EFIC - Pain in Europe XIII, Budapest, Hungary, 2023. Co-applicants: David Bulmer, University of Cambridge, Siobhain O’Mahony, UCC. | |
NeuroGastro 2019, Invited speaker | |
IBD 2017, Madrid, Spain | |
Invited speaker at EB2016, San Diego, USA | |
Invited speaker and session chair at RegPep 2016, Rouen, France | |
Invited participant of Little Brain Big Brain in Guangzhou, China (2014) and Wisconsin, USA (2009). | |
Invited speaker at Muscular Dystrophy Ireland, AGM, 2013. |
Teaching Activities
Teaching Interests
Programme Coordinator: MSc Clinical Physiology (2023 -
FM1010: Introductory Physiology (2011 - 2019)
MH1010: Introductory Physiology (2019-2020)
FM1040: Digestive Physiology (2012 -
MH1040: Digestive Physiology (2019 -
FM2101: Neuroscience (2014 -
MH2101: Neuroscience (2020 -
PL2033: The nervous system (2014 - Module coordinator
PL2034: Physiology for Dental students (2014 - Module coordinator, 2014-2018
PL3020: Neurophysiology (2017 - Module coordinator
PL3024: Digestive Physiology (2012 - Module coordinator
PL3025: Library project (2012 -
PL4014: Endocrine and Gastrointestinal Physiology (2015 - Module coordinator
PL4020: Research project (2013 -
MD3016: Human Physiology for Practitioner Paramedics (2017, module coordinator)
MX5090: Independent examiner for final year project
PG5005: (2008 - 2011) Postgraduate molecular techniques workshop (PhD students from a variety of departments), preparation and delivery of a lecture on cell culture and transfection techniques.
PF3008: (2009) Clinical Pharmacokinetics
Recent Postgraduates
| Graduation Year | Student Name | Institution | Degree Type | Thesis Title | |
|---|---|---|---|---|---|
| 2014 | Jennifer Manning | PhD | Immune and stress factors in the pathophysiology of the mdx mouse model of Duchenne Muscular Dystrophy | ||
| 0 | Rebecca O'Brien | University College Cork | PHD | ||
| 2023 | Kimberley Stephenson | University College Cork | PHD | Monoclonal xIL-6R antibodies as a treatment for memory dysfunction in the mdx mouse model of Duchenne Muscular Dystrophy. |
Research Information
Internal Collaborators
| Name | Institute | Country | |
|---|---|---|---|
| Prof Ken O'Halloran | University College Cork | IRELAND | |
| Dr Juliette Buckley | UCC | IRELAND | |
| Dr Mark Rae | University College Cork | IRELAND | |
| Dr Farouk Markos | University College Cork | IRELAND | |
| Dr Niall Hyland | University College Cork | IRELAND | |
| Prof Timothy G Dinan | University College Cork | IRELAND | |
| Dr Siobhain O'Mahony | University College Cork | IRELAND | |
| Deniz Yilmazar-Hanke | University of Creighton | U.S.A. |
External Collaborators
| Name | Organisation / Institute | Country | |
|---|---|---|---|
| Prof Eamonn Quigley | Houston Methodist Hospital | U.S.A. |