I am an integrative physiologist with diverse research interests and experience ranging from cardio-respiratory to gastrointestinal and renal physiology. Projects span the research landscape, including basic and applied research, patient-orientated research including observational and interventional studies in clinical populations as well as randomised-controlled trials, and field studies of cardio-respiratory and renal physiology at high altitude in sea-level natives (lowlanders). My research employs classical and contemporary multi-disciplinary experimental approaches and technologies in physiology, proteomics, redox biology, cell signalling, neuroscience, and respiratory medicine to explore the control of breathing and blood pressure in health and disease, in a variety of species, from genes to behaviour.
Current interests:
Therapeutic strategies to protect respiratory performance in mouse models of Duchenne muscular dystrophy.
We performed the first comprehensive assessment of respiratory system performance in the mdx mouse model of Duchenne muscular dystrophy (DMD). Our studies have revealed deficits and compensations at multiple sites in the integrative control of the respiratory musculature. We have demonstrated the efficacy of novel pharmacotherapy strategies and recently demonstrated that accessory muscles of breathing afford remarkable compensation for diaphragm muscle weakness in the dystrophic mouse, which we demonstrated is lost with progressive disease. This finding has implications for treatments and rehabilitative interventions in people with DMD. We are currently characterising the elaboration of respiratory system impairments in progressive dystrophic disease models, wherein we are exploring the efficacy of novel therapeutic strategies that combine neurotherapeutic and pharmacotherapeutic strategies.
See recent seminar: "Control of breathing in neuromuscular disease: Lessons from the mdx mouse model of muscular dystrophy" presented by David Burns and Ken O'Halloran.
https://www.youtube.com/watch?v=DwgjODCjqXc
Key publications:
O'Halloran KD, Maxwell MN, Marullo AL, Hamilton CP, Murchú S, Burns DP, Mahony CM, Slyne AD, and Drummond SE (2023). Loss of compensation afforded by accessory muscles of breathing leads to respiratory system compromise in the mdx mouse model of Duchenne muscular dystrophy.
Journal of Physiology 601(19):4441-4467.
Burns DP, Lucking EF, O'Halloran KD (2019). Auxiliary compensation for diaphragm dysfunction in dystrophic disease. Journal of Physiology 597 (15):4103-4105.
Burns DP, Murphy KH, Lucking EF, O'Halloran KD. (2019). Inspiratory pressure-generating capacity is preserved during ventilatory and non-ventilatory behaviours in young dystrophic mdx mice despite profound diaphragm muscle weakness. Journal of Physiology 597, 831-848.
Burns DP, Canavan L, Rowland J, O'Flaherty R, Brannock M, Drummond SE, O'Malley D, Edge D, O'Halloran KD. (2018). Recovery of respiratory function in mdx mice co-treated with neutralizing interleukin-6 receptor antibodies and Urocortin-2. Journal of Physiology 516, 5175-5197.
Burns DP, Roy A, Lucking EF, McDonald FB, Gray S, Wilson RJ, Edge D, O'Halloran KD. (2017). Sensorimotor control of breathing in the mdx mouse model of Duchenne muscular dystrophy. Journal of Physiology 595, 6653-6672.
INSPIRE DMD: Interventional strategies to protect and increase respiratory efficacy in Duchenne muscular dystrophy. Funded by Science Foundation Ireland.
PhD researchers Misha Maxwell, Tony Marullo, and Aoife Slyne (funded by Eli Lilly doctoral scholarship) are characterising respiratory control in mouse models of muscular dystrophy. Misha is exploring the efficacy of novel therapeutics in ameliorating respiratory system compromise in mdx mice. Tony is exploring the gut-muscle axis, employing metagenomic and metabolomic analyses with a view to gut microbial directed strategies to improve muscle function in mdx mice. Aoife is characterising respiratory control in early and advanced dystrophic disease and will explore the efficacy of gene therapy in improving respiratory system function in collaboration with colleagues at Duke University, USA.
Cardio-respiratory effects of exposure to chronic intermittent hypoxia modelling human sleep-disordered breathing.
We use animal models to explore the effects of exposure to cyclical hypoxia on the cardiovascular and respiratory systems. Our findings highlight that chronic intermittent hypoxia (CIH),modelling the pattern of oxygen dysregulation in human sleep apnoea, has deleterious effects on cardio-respiratory control. CIH causes respiratory muscle weakness and fatigue, impairs motor control of respiratory muscles regulating upper airway calibre and destabilizes ventilatory control giving rise to disordered breathing during sleep. Our work has revealed that CIH alters redox status in muscle and the neural networks controlling them. We have established that CIH-induced dysfunction in the respiratory system is amenable to antioxidant interventions, suggesting their potential use as adjunctive therapies in human sleep apnoea. We have used transgenic and pharmacological approaches to reveal that the superoxide-generating enzyme NADPH oxidase is pivotal to CIH-induced respiratory muscle weakness. Indeed, studies in NOX2 null mice reveal a fundamental role for NADPH oxidase-dependent redox signalling in respiratory muscle function per se.
Key publications:
Drummond SE, Burns DP, El Maghrani S, Ziegler O, Healy V, O'Halloran KD (2023). Chronic intermittent hypoxia-induced diaphragm muscle weakness is NADPH Oxidase-2 dependent.
Cells 12(14):1834.
McDonald FB, Dempsey EM, O'Halloran KD (2016). Early life exposure to chronic intermittent hypoxia primes increased susceptibility to hypoxia-induced weakness in rat sternohyoid muscle during adulthood. Frontiers in Physiology 7, 69.
McDonald FB, Williams R, Sheehan D, O'Halloran KD (2015). Early life exposure to chronic intermittent hypoxia causes upper airway dilator muscle weakness which persists into young adulthood. Experimental Physiology 100, 947-966.
Williams R, Lemaire P, Lewis P, McDonald FB, Lucking EF, Hogan S, Sheehan D, Healy V, O'Halloran KD (2015). Chronic intermittent hypoxia increases rat sternohyoid muscle NADPH oxidase expression with attendant modest oxidative stress. Frontiers in Physiology 6, 15.
Edge D, McDonald FB, Jones JFX, Bradford A, O'Halloran KD (2014).Effect of chronic intermittent hypoxia on the reflex recruitment of the genioglossus during airway obstruction in the anaesthetized rat. Progress in Brain Research 209, 147-168.
Shortt CM, Fredsted F, Chow HB, Williams R, Skelly JR, Edge D, Bradford A, O'Halloran KD (2014). Reactive oxygen species mediated diaphragm fatigue in a rat model of chronic intermittent hypoxia. Experimental Physiology, 99 :688-700.
Edge D, Bradford A, O'Halloran KD (2012). Chronic intermittent hypoxia increases apnoea index in sleeping rats. Advances In Experimental Medicine and Biology 758, 359-363.
Skelly JR, Edge D, Shortt CM, Jones JFX, Bradford A, O'Halloran KD. (2012). Tempol ameliorates pharyngeal dilator muscle dysfunction in a rodent model of chronic intermittent hypoxia. American Journal of Respiratory Cell and Molecular Biology, 46 :139-148.
Renal afferent mechanisms contributing to chronic intermittent hypoxia-induced hypertension.
In collaboration with Dr Mohammed Abdulla, we are exploring the potential for aberrant afferent signalling from the kidneys to drive neurogenic hypertension in animals exposed to chronic intermittent hypoxia, modelling human sleep apnoea. We examined baroreflex control of blood pressure in rats exposed to chronic intermittent hypoxia with a focus on intra-renal signalling mechanisms that may contribute to sympathetic nervous over-activity. The work extends previous studies exploring the effects of exposure to intermittent hypoxia on renal oxygen homeostasis and renal function.
Key publications:
AlMarabeh S, Lucking EF, O'Halloran KD, Abdulla MH (2022). Intrarenal pelvic bradykinin-induced sympathoexcitatory reno-renal reflex is attenuated in rats exposed to chronic intermittent hypoxia.
AlMarabeh S, O'Neill J, Cavers J, Lucking EF, O'Halloran KD, Abdulla MH (2020). Chronic intermittent hypoxia impairs diuretic and natriuretic responses to volume expansion in rats with preserved low-pressure baroreflex control of the kidney. American Journal of Physiology (Renal), 320(1):F1-F16.
AlMarabeh S, Abdulla MH, O'Halloran KD (2019). Is aberrant reno-renal reflex control of blood pressure a contributor to chronic intermittent hypoxia-induced hypertension?' Frontiers in Physiology 10, 465.
O'Neill J, Jasionek G, Drummond SE, Brett O, Lucking EF, Abdulla MH, O'Halloran KD. (2019). Renal cortical oxygen tension is decreased following exposure to long-term but not short-term intermittent hypoxia in the rat. American Journal of Physiology (Renal) 316, F635-645.
Cardio-respiratory, renal and cerebrovascular function in humans at high altitude.
In collaboration with Professor Trevor Day, Dr Jack Leacy studies neurovascular coupling in humans as a measure of cerebrovascular function. Our work is lab-based at UCC and Mount Royal University (Calgary), but extends to high altitude field studies exploring cerebrovascular function and brain oxygenation during acute and chronic exposure to the low oxygen environment of high altitude (3,800-5,000m). In collaboration with international colleagues we have participated in expeditions at the Barcroft Laboratory, White Mountain Research Station, California and Everest Base Camp, Nepal. We are also exploring cardio-respiratory and renal acclimatization to high altitude. More recently, Dr Leacy has initiated studies in pre- and post-menopausal women.
Key publications:
Leacy JK, Linares AM, Zouboules SM, Rampuri ZH, Bird JD, Herrington BA, Mann L, Soriano JE, Thrall SF, Kalker A, Brutsaert T, O'Halloran KD, Sherpa MT, Day TA (2020). Cardiorespiratory hysteresis during incremental high altitude ascent-descent quantifies the magnitude of ventilatory acclimatization. Experimental Physiology 106(1):139-150.
The role of the microbiota-gut-brain axis in cardio-respiratory control in health and disease.
In collaboration with Prof Ger Clark, Prof John Cryan and colleagues at Teagasc Moorepark, we have explored the effects of manipulations of the gut microbiota on cardio-respiratory function in rodent models. We revealed that disruption to the gut microbiota was associated with altered brainstem neurochemistry and dysregulated respiratory and autonomic control. We have also shown that CIH, modelling human sleep apnoea, alters the gut microbiota composition. We recently explored the efficacy of a prebiotic dietary intervention which altered the gut microbiota and increased short-chain fatty acid concentrations, but failed to prevent CIH-induced apnoea and hypertension.
Key publications:
O’Connor KM, Lucking EF, Bastiaanssen TFS, Peterson VL, Crispie F, Cotter PD, Clarke G, Cryan JF, O’Halloran KD (2020). Prebiotic administration modulates gut microbiota and faecal short-chain fatty acid concentrations but does not prevent chronic intermittent hypoxia-induced apnoea and hypertension in adult rats. EBiomedicine 59:102968.
O'Connor KM, Lucking EF, Cryan JF, O'Halloran KD (2020). Bugs, breathing and blood pressure: microbiota-gut-brain axis signalling in cardiorespiratory control in health and disease'. The Journal of Physiology 598(19):4159-4179.
O’Connor KM, Lucking EF, Golubeva AV, Strain CR, Fouhy F, Cenit MC, Dhaliwal P, Bastiaanssen TFS, Burns DP, Stanton C, Clarke G, Cryan JF, O’Halloran KD. (2019). Manipulation of gut microbiota blunts the ventilatory response to hypercapnia in adult rats. EBiomedicine 44, 618-638.
Lucking EF, O'Connor KM, Strain CR, Fouhy F, Bastiaanssen TF, Burns DP, Golubeva AV, Stanton C, Clarke G, Cryan JF, O'Halloran KD (2018). Chronic intermittent hypoxia disrupts cardiorespiratory homeostasis and gut microbiota composition in adult male guinea-pigs. EBiomedicine 38, 191-205.
Respiratory muscle weakness in animal models of sustained hypoxia.
Hypoxia (low oxygen) occurs at altitude and in acute and chronic respiratory diseases. We have shown that hypoxia causes redox remodelling in respiratory muscles leading to weakness. Prolonged exposure to hypoxia causes protein breakdown, atrophy and profound weakness in diaphragm and upper airway muscles. Diaphragm weakness is predictive of poor patient outcome with increased morbidity and mortality. In critically-ill patients in the ICU, mechanical ventilation, infection, and sepsis cause profound diaphragm weakness which can prolong ICU stays delaying weaning from the ventilator. Hypoxia is a feature of acute critical illness and may exacerbate respiratory muscle dysfunction. We have shown that antioxidants can ameliorate hypoxia induced respiratory muscle structural and functional remodelling, with N-acetyl cysteine, a dietary supplement, emerging as the most efficacious in studies in rodent models. Our work suggests that antioxidant strategies may have use as adjunctive therapies in the treatment of people with hypoxic respiratory disease.
Key publications:
O'Leary AJ, Drummond SE, Edge D, O'Halloran KD (2018). Diaphragm muscle weakness following acute sustained hypoxic stress in the mouse is prevented by pre-treatment with N-acetyl cysteine'. Oxidative Medicine and Cellular Longevity 2018, 4805493.
Greising SM, Ottenheijm CAC, O'Halloran KD, Barreiro E. (2018). Diaphragm plasticity in aging and disease: therapies for muscle weakness go from strength to strength'. Journal of Applied Physiology 125, 243-253.
Lewis P, O'Halloran KD (2016). Diaphragm muscle adaptation to sustained hypoxia: lessons from animal models with relevance to high altitude and chronic respiratory diseases. Frontiers in Physiology 7, 623.
Lewis P, Sheehan D, Soares R, Varela Coelho A, O'Halloran KD (2016). Redox remodeling is pivotal in murine diaphragm muscle adaptation to chronic sustained hypoxia. American Journal of Respiratory Cell and Molecular Biology 55, 12-23.
Lewis P, Sheehan D, Soares R, Coelho AV, O'Halloran KD (2015). Chronic sustained hypoxia-induced redox remodeling causes contractile dysfunction in mouse sternohyoid muscle'. Frontiers in Physiology 6, 122.
Carberry J, McMorrow C, Bradford A, Jones JFX, O'Halloran KD (2014) 'Effects of sustained hypoxia on sternohyoid and diaphragm muscle during development'. European Respiratory Journal 43,1149-1158.
McMorrow C, Fredsted A, O'Connell RA, Carberry J, Bradford A, Jones JFX, O'Halloran KD. (2011) 'Chronic hypoxia increases rat diaphragm muscle endurance and sodium-potassium ATPase pump content'. European Respiratory Journal 37, 1474-1481.
Thank you to the team!
Many colleagues have contributed to the above and many other research studies over the years. I am grateful to them for their energy and enthusiasm leading to fruitful outcomes and especially for the camaraderie along the way.
Funding.
Projects funded by the Health Research Board, Irish Research Council, Muscular Dystrophy Ireland, Duchenne Parent Project, and Science Foundation Ireland.
Collaborations:
Exercising control over runaway kynurenine pathway metabolism: Towards improved treatment outcomes in major depression.
With Dr. Jason Martin, Prof. Ted Dinan, Prof. John Cryan & Dr. Ger Clarke. Funded by the Health Research Board.
A trilogy of stressors in the NICU: Towards therapy for preterm adversity.
With Dr. Karen O'Connor, Maria Casacao & Dr. Fiona McDonald (SFI SIRG Investigator). Funded by Science Foundation Ireland.
Improving long-term patient recovery and reducing disability after COVID-19 critical illness using microRNA-based approaches.
With Dr. David Burns (UCC), Dr. Bairbre McNicholas (GUH), Prof. John Laffey (NUIG), Dr. Ronan O'Caoimh (MUH), Dr Brian McDonagh (NUIG), Dr Katarzyna Whysall (NUIG). Funded by the Health Research Board.
Gene therapy for Duchenne muscular dystrophy.
With Prof Mai ElMallah at Duke University, USA.
FM 1030 / MH 1030 Respiratory Biology & Metabolism
MH 1050 Introduction to Translational Medicine
PL 3001 Pathophysiology
PL 3025 Literature Review, Experimental Design and Data Analysis
PL 3022 Respiratory Physiology
AN 3003 Neurobiology of Regulatory Systems
MH 3010 Systematic Literature Review
PL 4010 Control of Breathing in Health & Disease
PL 4020 Research Project (final year BSc Physiology)
MH 4010 Research Project (final year BSc Medicine & Health)
Postgraduate
DS7100: Basic Science Relevant to Oral Surgery Practice
Biography
2011-present Professor of Physiology, UCC.
2006-2011 Senior Lecturer, University College Dublin (UCD).
2000-2006 Lecturer, UCD.
1996-2000 Postdoctoral Fellow, UW-Madison, USA.
1995-1996 Postdoctoral Fellow, UNC Chapel Hill, USA.
1992-1995 PhD, RCSI & UCD (HRB-funded).
1988-1992 BSc (Hons) Physiology, UCC.
University Roles
2018-present Vice-Head, School of Medicine
2015-present Research Integrity Officer
2012-2015 Lead Co-ordinator, Pre-clinical (Foundations) Medicine
2011-present Director, Biological Services Unit
2011-present Head, Department of Physiology
External Roles
2019-2024 Senior Editor, Journal of Physiology
2015-2024 Senior Editor, Experimental Physiology
2014-2017 Meetings Secretary, The Physiological Society
2014-2017 Executive Committee, The Physiological Society
2012-2017 Trustee & Council Member, The Physiological Society
2011-2019 General Secretary, Royal Academy of Medicine in Ireland
2013-2015 External Examiner, Trinity College Dublin.
2010-2013 External Examiner, Imperial College, London, UK.
Biography: I am an integrative physiologist with interests in cardiorespiratory physiology, as well as other organ systems. My primary research interest is the control of breathing in health and disease, with a current focus on respiratory muscle physiology, and neural control of respiratory behaviour in models of neuromuscular disease. I have published 242 peer-reviewed articles in leading international basic science and clinical journals, together with >300 conference publications. I have been an invited speaker and I have organised and chaired symposia at international conferences in Europe, Asia, Australia, and North and South America. I was Meetings Secretary of The Physiological Society (2014-2017) responsible for the scientific meetings portfolio of The Society. I have served on several international conference programme committees, including the International Union of Physiological Sciences 2017. I have several editor roles, including senior editor of Experimental Physiology and The Journal of Physiology. I have served as expert reviewer for several international funding agencies including the Medical Research Council UK, British Heart Foundation (UK), BBSRC (UK), ANR (French National Research Agency), Vici Awards (Netherlands), and the European Commission including ERC awards.
Teaching: I contribute to 12 modules across 6 academic programmes in the College of Medicine & Health and College of Science, Engineering and Food Science.
Research Training: I have supervised 17 PhD and 5 MSc researchers to completion. Work performed by postgraduate researchers collaboratively in my laboratory has contributed to a further 3 PhD theses. I currently supervise 4 PhD researchers and co-supervise 2 others. Trainees have received awards for their research (e.g. Pfizer Prize, The Physiological Society; Usha Award, American Physiological Society; Anne E. Suratt Prize, Sleep & Breathing International Conference; International Society for Arterial Chemoreception; Research Awards, Royal Academy of Medicine in Ireland), been selected to present talks at international conferences, and have published outcomes in leading basic science and clinical international journals. Alumni have been recruited to leading laboratories internationally and have been appointed to academic, clinical and industry posts.
Research Publications: 242 research publications in leading peer-reviewed journals (178 as senior author). Research outputs in basic science and clinical journals relating to respiratory physiology, respiratory medicine, cardiovascular physiology, gastrointestinal physiology, redox biology, muscular dystrophy, clinical physiology, neuroscience, dentistry, and neonatalogy. Research studies are primarily basic and applied multi-disciplinary biomedical science centred on integrative systems-based physiology, but also include recent collaborations employing randomized controlled trials in clinical populations, and studies of integrative physiology at high altitude.
Research Funding: Awarded ~4M in competitive funding. Competitive peer-reviewed awards from Science Foundation Ireland (1M, 2013; 552k in 2020), the Health Research Board (678k in 4 awards, 2005-2013; 370k in 2017), and a range of additional seed, scholarship, equipment and strategic funding from Irish Research Council, Duchenne Parent Project, Muscular Dystrophy Ireland, and University College Dublin, and University College Cork.
Industry collaboration: Covidien and Bluebridge Technologies (contract pre-clinical research in small and large animal models related to medical device design).
2006-2011 Senior Lecturer, University College Dublin (UCD).
2000-2006 Lecturer, UCD.
1996-2000 Postdoctoral Fellow, UW-Madison, USA.
1995-1996 Postdoctoral Fellow, UNC Chapel Hill, USA.
1992-1995 PhD, RCSI & UCD (HRB-funded).
1988-1992 BSc (Hons) Physiology, UCC.
University Roles
2018-present Vice-Head, School of Medicine
2015-present Research Integrity Officer
2012-2015 Lead Co-ordinator, Pre-clinical (Foundations) Medicine
2011-present Director, Biological Services Unit
2011-present Head, Department of Physiology
External Roles
2019-2024 Senior Editor, Journal of Physiology
2015-2024 Senior Editor, Experimental Physiology
2014-2017 Meetings Secretary, The Physiological Society
2014-2017 Executive Committee, The Physiological Society
2012-2017 Trustee & Council Member, The Physiological Society
2011-2019 General Secretary, Royal Academy of Medicine in Ireland
2013-2015 External Examiner, Trinity College Dublin.
2010-2013 External Examiner, Imperial College, London, UK.
Biography: I am an integrative physiologist with interests in cardiorespiratory physiology, as well as other organ systems. My primary research interest is the control of breathing in health and disease, with a current focus on respiratory muscle physiology, and neural control of respiratory behaviour in models of neuromuscular disease. I have published 242 peer-reviewed articles in leading international basic science and clinical journals, together with >300 conference publications. I have been an invited speaker and I have organised and chaired symposia at international conferences in Europe, Asia, Australia, and North and South America. I was Meetings Secretary of The Physiological Society (2014-2017) responsible for the scientific meetings portfolio of The Society. I have served on several international conference programme committees, including the International Union of Physiological Sciences 2017. I have several editor roles, including senior editor of Experimental Physiology and The Journal of Physiology. I have served as expert reviewer for several international funding agencies including the Medical Research Council UK, British Heart Foundation (UK), BBSRC (UK), ANR (French National Research Agency), Vici Awards (Netherlands), and the European Commission including ERC awards.
Teaching: I contribute to 12 modules across 6 academic programmes in the College of Medicine & Health and College of Science, Engineering and Food Science.
Research Training: I have supervised 17 PhD and 5 MSc researchers to completion. Work performed by postgraduate researchers collaboratively in my laboratory has contributed to a further 3 PhD theses. I currently supervise 4 PhD researchers and co-supervise 2 others. Trainees have received awards for their research (e.g. Pfizer Prize, The Physiological Society; Usha Award, American Physiological Society; Anne E. Suratt Prize, Sleep & Breathing International Conference; International Society for Arterial Chemoreception; Research Awards, Royal Academy of Medicine in Ireland), been selected to present talks at international conferences, and have published outcomes in leading basic science and clinical international journals. Alumni have been recruited to leading laboratories internationally and have been appointed to academic, clinical and industry posts.
Research Publications: 242 research publications in leading peer-reviewed journals (178 as senior author). Research outputs in basic science and clinical journals relating to respiratory physiology, respiratory medicine, cardiovascular physiology, gastrointestinal physiology, redox biology, muscular dystrophy, clinical physiology, neuroscience, dentistry, and neonatalogy. Research studies are primarily basic and applied multi-disciplinary biomedical science centred on integrative systems-based physiology, but also include recent collaborations employing randomized controlled trials in clinical populations, and studies of integrative physiology at high altitude.
Research Funding: Awarded ~4M in competitive funding. Competitive peer-reviewed awards from Science Foundation Ireland (1M, 2013; 552k in 2020), the Health Research Board (678k in 4 awards, 2005-2013; 370k in 2017), and a range of additional seed, scholarship, equipment and strategic funding from Irish Research Council, Duchenne Parent Project, Muscular Dystrophy Ireland, and University College Dublin, and University College Cork.
Industry collaboration: Covidien and Bluebridge Technologies (contract pre-clinical research in small and large animal models related to medical device design).
Research Interests
The major focus of our research is cardio-respiratory function in health and disease.I am an integrative physiologist with diverse research interests and experience ranging from cardio-respiratory to gastrointestinal and renal physiology. Projects span the research landscape, including basic and applied research, patient-orientated research including observational and interventional studies in clinical populations as well as randomised-controlled trials, and field studies of cardio-respiratory and renal physiology at high altitude in sea-level natives (lowlanders). My research employs classical and contemporary multi-disciplinary experimental approaches and technologies in physiology, proteomics, redox biology, cell signalling, neuroscience, and respiratory medicine to explore the control of breathing and blood pressure in health and disease, in a variety of species, from genes to behaviour.
Current interests:
Therapeutic strategies to protect respiratory performance in mouse models of Duchenne muscular dystrophy.
We performed the first comprehensive assessment of respiratory system performance in the mdx mouse model of Duchenne muscular dystrophy (DMD). Our studies have revealed deficits and compensations at multiple sites in the integrative control of the respiratory musculature. We have demonstrated the efficacy of novel pharmacotherapy strategies and recently demonstrated that accessory muscles of breathing afford remarkable compensation for diaphragm muscle weakness in the dystrophic mouse, which we demonstrated is lost with progressive disease. This finding has implications for treatments and rehabilitative interventions in people with DMD. We are currently characterising the elaboration of respiratory system impairments in progressive dystrophic disease models, wherein we are exploring the efficacy of novel therapeutic strategies that combine neurotherapeutic and pharmacotherapeutic strategies.
See recent seminar: "Control of breathing in neuromuscular disease: Lessons from the mdx mouse model of muscular dystrophy" presented by David Burns and Ken O'Halloran.
https://www.youtube.com/watch?v=DwgjODCjqXc
Key publications:
O'Halloran KD, Maxwell MN, Marullo AL, Hamilton CP, Murchú S, Burns DP, Mahony CM, Slyne AD, and Drummond SE (2023). Loss of compensation afforded by accessory muscles of breathing leads to respiratory system compromise in the mdx mouse model of Duchenne muscular dystrophy.
Journal of Physiology 601(19):4441-4467.
Mhandire DZ, Burns DP, Roger AL, O'Halloran KD, ElMallah MK (2022). Breathing in Duchenne muscular dystrophy: translation to therapy.
Journal of Physiology 600(15):3465-3482.
Burns DP, Drummond SE, Bolger D, Coiscaud A, Murphy KH, Edge D, O'Halloran KD (2019). N-acetylcysteine decreases fibrosis and increases force-generating capacity of mdx diaphragm. Antioxidants 8, 581.Journal of Physiology 600(15):3465-3482.
Burns DP, Lucking EF, O'Halloran KD (2019). Auxiliary compensation for diaphragm dysfunction in dystrophic disease. Journal of Physiology 597 (15):4103-4105.
Burns DP, Murphy KH, Lucking EF, O'Halloran KD. (2019). Inspiratory pressure-generating capacity is preserved during ventilatory and non-ventilatory behaviours in young dystrophic mdx mice despite profound diaphragm muscle weakness. Journal of Physiology 597, 831-848.
Burns DP, Canavan L, Rowland J, O'Flaherty R, Brannock M, Drummond SE, O'Malley D, Edge D, O'Halloran KD. (2018). Recovery of respiratory function in mdx mice co-treated with neutralizing interleukin-6 receptor antibodies and Urocortin-2. Journal of Physiology 516, 5175-5197.
Burns DP, Roy A, Lucking EF, McDonald FB, Gray S, Wilson RJ, Edge D, O'Halloran KD. (2017). Sensorimotor control of breathing in the mdx mouse model of Duchenne muscular dystrophy. Journal of Physiology 595, 6653-6672.
INSPIRE DMD: Interventional strategies to protect and increase respiratory efficacy in Duchenne muscular dystrophy. Funded by Science Foundation Ireland.
PhD researchers Misha Maxwell, Tony Marullo, and Aoife Slyne (funded by Eli Lilly doctoral scholarship) are characterising respiratory control in mouse models of muscular dystrophy. Misha is exploring the efficacy of novel therapeutics in ameliorating respiratory system compromise in mdx mice. Tony is exploring the gut-muscle axis, employing metagenomic and metabolomic analyses with a view to gut microbial directed strategies to improve muscle function in mdx mice. Aoife is characterising respiratory control in early and advanced dystrophic disease and will explore the efficacy of gene therapy in improving respiratory system function in collaboration with colleagues at Duke University, USA.
Cardio-respiratory effects of exposure to chronic intermittent hypoxia modelling human sleep-disordered breathing.
We use animal models to explore the effects of exposure to cyclical hypoxia on the cardiovascular and respiratory systems. Our findings highlight that chronic intermittent hypoxia (CIH),modelling the pattern of oxygen dysregulation in human sleep apnoea, has deleterious effects on cardio-respiratory control. CIH causes respiratory muscle weakness and fatigue, impairs motor control of respiratory muscles regulating upper airway calibre and destabilizes ventilatory control giving rise to disordered breathing during sleep. Our work has revealed that CIH alters redox status in muscle and the neural networks controlling them. We have established that CIH-induced dysfunction in the respiratory system is amenable to antioxidant interventions, suggesting their potential use as adjunctive therapies in human sleep apnoea. We have used transgenic and pharmacological approaches to reveal that the superoxide-generating enzyme NADPH oxidase is pivotal to CIH-induced respiratory muscle weakness. Indeed, studies in NOX2 null mice reveal a fundamental role for NADPH oxidase-dependent redox signalling in respiratory muscle function per se.
Key publications:
Drummond SE, Burns DP, El Maghrani S, Ziegler O, Healy V, O'Halloran KD (2023). Chronic intermittent hypoxia-induced diaphragm muscle weakness is NADPH Oxidase-2 dependent.
Cells 12(14):1834.
Drummond SE, Burns DP, Maghrani SE, Ziegler O, Healy V, O'Halloran KD (2022). NADPH oxidase 2 is necessary for chronic intermittent hypoxia-induced sternohyoid muscle weakness in adult male mice. Experimental Physiology 107(8):946-964.
McDonald FB, Dempsey EM, O'Halloran KD (2016). Effects of gestational and postnatal exposure to chronic intermittent hypoxia on diaphragm muscle contractile function in the rat. Frontiers in Physiology 7, 276.Drummond SE, Burns DP, O'Connor KM, Clarke G, O'Halloran KD (2021). The role of NADPH oxidase in chronic intermittent hypoxia-induced respiratory plasticity in adult male mice. Respir Physiol Neurobiol. 292:103713.
McDonald FB, Dempsey EM, O'Halloran KD (2016). Early life exposure to chronic intermittent hypoxia primes increased susceptibility to hypoxia-induced weakness in rat sternohyoid muscle during adulthood. Frontiers in Physiology 7, 69.
McDonald FB, Williams R, Sheehan D, O'Halloran KD (2015). Early life exposure to chronic intermittent hypoxia causes upper airway dilator muscle weakness which persists into young adulthood. Experimental Physiology 100, 947-966.
Williams R, Lemaire P, Lewis P, McDonald FB, Lucking EF, Hogan S, Sheehan D, Healy V, O'Halloran KD (2015). Chronic intermittent hypoxia increases rat sternohyoid muscle NADPH oxidase expression with attendant modest oxidative stress. Frontiers in Physiology 6, 15.
Edge D, McDonald FB, Jones JFX, Bradford A, O'Halloran KD (2014).Effect of chronic intermittent hypoxia on the reflex recruitment of the genioglossus during airway obstruction in the anaesthetized rat. Progress in Brain Research 209, 147-168.
Shortt CM, Fredsted F, Chow HB, Williams R, Skelly JR, Edge D, Bradford A, O'Halloran KD (2014). Reactive oxygen species mediated diaphragm fatigue in a rat model of chronic intermittent hypoxia. Experimental Physiology, 99 :688-700.
Edge D, Bradford A, O'Halloran KD (2012). Chronic intermittent hypoxia increases apnoea index in sleeping rats. Advances In Experimental Medicine and Biology 758, 359-363.
Skelly JR, Edge D, Shortt CM, Jones JFX, Bradford A, O'Halloran KD. (2012). Tempol ameliorates pharyngeal dilator muscle dysfunction in a rodent model of chronic intermittent hypoxia. American Journal of Respiratory Cell and Molecular Biology, 46 :139-148.
Renal afferent mechanisms contributing to chronic intermittent hypoxia-induced hypertension.
In collaboration with Dr Mohammed Abdulla, we are exploring the potential for aberrant afferent signalling from the kidneys to drive neurogenic hypertension in animals exposed to chronic intermittent hypoxia, modelling human sleep apnoea. We examined baroreflex control of blood pressure in rats exposed to chronic intermittent hypoxia with a focus on intra-renal signalling mechanisms that may contribute to sympathetic nervous over-activity. The work extends previous studies exploring the effects of exposure to intermittent hypoxia on renal oxygen homeostasis and renal function.
Key publications:
AlMarabeh S, Lucking EF, O'Halloran KD, Abdulla MH (2022). Intrarenal pelvic bradykinin-induced sympathoexcitatory reno-renal reflex is attenuated in rats exposed to chronic intermittent hypoxia.
Journal of Hypertension, 40(1):46-64.
AlMarabeh S, O'Neill J, Cavers J, Lucking EF, O'Halloran KD, Abdulla MH (2020). Chronic intermittent hypoxia impairs diuretic and natriuretic responses to volume expansion in rats with preserved low-pressure baroreflex control of the kidney. American Journal of Physiology (Renal), 320(1):F1-F16.
AlMarabeh S, Abdulla MH, O'Halloran KD (2019). Is aberrant reno-renal reflex control of blood pressure a contributor to chronic intermittent hypoxia-induced hypertension?' Frontiers in Physiology 10, 465.
O'Neill J, Jasionek G, Drummond SE, Brett O, Lucking EF, Abdulla MH, O'Halloran KD. (2019). Renal cortical oxygen tension is decreased following exposure to long-term but not short-term intermittent hypoxia in the rat. American Journal of Physiology (Renal) 316, F635-645.
Cardio-respiratory, renal and cerebrovascular function in humans at high altitude.
In collaboration with Professor Trevor Day, Dr Jack Leacy studies neurovascular coupling in humans as a measure of cerebrovascular function. Our work is lab-based at UCC and Mount Royal University (Calgary), but extends to high altitude field studies exploring cerebrovascular function and brain oxygenation during acute and chronic exposure to the low oxygen environment of high altitude (3,800-5,000m). In collaboration with international colleagues we have participated in expeditions at the Barcroft Laboratory, White Mountain Research Station, California and Everest Base Camp, Nepal. We are also exploring cardio-respiratory and renal acclimatization to high altitude. More recently, Dr Leacy has initiated studies in pre- and post-menopausal women.
Key publications:
Leacy JK, Johnson EM, Lavoie LR, Macilwraith DN, Bambury M, Martin JA, Lucking EF, Linares AM, Saran G, Sheehan DP, Sharma N, Day TA, O'Halloran KD (2022). Variation within the visually evoked neurovascular coupling response of the posterior cerebral artery is not influenced by age or sex. Journal of Applied Physiology133(2):335-348.
Bird JD, Leacy JK, Foster GE, Rickards CA, Wilson RJA, O'Halloran KD, Jendzjowsky NG, Pentz BA, Byman BRM, Thrall SF, Skalk AL, Hewitt SA, Steinback CD, Burns D, Ondrus P, Day TA (2021). Time course and magnitude of ventilatory and renal acid-base acclimatization following rapid ascent to and residence at 3,800 m over nine days. Journal of Applied Physiology 130(6):1705-1715.Leacy JK, Linares AM, Zouboules SM, Rampuri ZH, Bird JD, Herrington BA, Mann L, Soriano JE, Thrall SF, Kalker A, Brutsaert T, O'Halloran KD, Sherpa MT, Day TA (2020). Cardiorespiratory hysteresis during incremental high altitude ascent-descent quantifies the magnitude of ventilatory acclimatization. Experimental Physiology 106(1):139-150.
Palubiski LM, O'Halloran KD, O'Neill J.(2020). Renal physiological adaptation to high altitude: A systematic review. Frontiers in Physiology 11, 756.
Leacy JK, Day TA, O'Halloran KD (2019). Is alkalosis the dominant factor in hypoxia-induced cognitive dysfunction? Experimental Physiology 104, 1443-1444.
Leacy JK, Zouboules SM, Mann CR, Peltonen JDB, Saran G, Nysten CE, Nysten HE, Brutsaert TD, O’Halloran KD, Sherpa MT, Day TA. (2018). Neurovascular coupling remains intact during incremental ascent to high altitude (4240m) in acclimatized healthy volunteers. Frontiers in Physiology 9, 1691.
Bruce CD, Saran G, Pfoh JR, Leacy JK, Zouboules SM, Mann CR, Peltonen JDB, Linares AM, Chiew AE, O'Halloran KD, Sherpa MT, Day TA. (2018). What Is the Point of the Peak? Assessing Steady-State Respiratory Chemoreflex Drive in High Altitude Field Studies. Advances In Experimental Medicine and Biology 1071, 13-23.
Zouboules SM, Lafave HC, O'Halloran KD, Brutsaert T, Nysten HE, Nysten CE, Steinback CD, Sherpa MT, Day TA (2018). Renal reactivity: Acid-base compensation during incremental ascent to high altitude'. Journal of Physiology 596, 6191-6203.
Leacy JK, Day TA, O'Halloran KD (2019). Is alkalosis the dominant factor in hypoxia-induced cognitive dysfunction? Experimental Physiology 104, 1443-1444.
Leacy JK, Zouboules SM, Mann CR, Peltonen JDB, Saran G, Nysten CE, Nysten HE, Brutsaert TD, O’Halloran KD, Sherpa MT, Day TA. (2018). Neurovascular coupling remains intact during incremental ascent to high altitude (4240m) in acclimatized healthy volunteers. Frontiers in Physiology 9, 1691.
Bruce CD, Saran G, Pfoh JR, Leacy JK, Zouboules SM, Mann CR, Peltonen JDB, Linares AM, Chiew AE, O'Halloran KD, Sherpa MT, Day TA. (2018). What Is the Point of the Peak? Assessing Steady-State Respiratory Chemoreflex Drive in High Altitude Field Studies. Advances In Experimental Medicine and Biology 1071, 13-23.
Zouboules SM, Lafave HC, O'Halloran KD, Brutsaert T, Nysten HE, Nysten CE, Steinback CD, Sherpa MT, Day TA (2018). Renal reactivity: Acid-base compensation during incremental ascent to high altitude'. Journal of Physiology 596, 6191-6203.
The role of the microbiota-gut-brain axis in cardio-respiratory control in health and disease.
In collaboration with Prof Ger Clark, Prof John Cryan and colleagues at Teagasc Moorepark, we have explored the effects of manipulations of the gut microbiota on cardio-respiratory function in rodent models. We revealed that disruption to the gut microbiota was associated with altered brainstem neurochemistry and dysregulated respiratory and autonomic control. We have also shown that CIH, modelling human sleep apnoea, alters the gut microbiota composition. We recently explored the efficacy of a prebiotic dietary intervention which altered the gut microbiota and increased short-chain fatty acid concentrations, but failed to prevent CIH-induced apnoea and hypertension.
Key publications:
O’Connor KM, Lucking EF, Bastiaanssen TFS, Peterson VL, Crispie F, Cotter PD, Clarke G, Cryan JF, O’Halloran KD (2020). Prebiotic administration modulates gut microbiota and faecal short-chain fatty acid concentrations but does not prevent chronic intermittent hypoxia-induced apnoea and hypertension in adult rats. EBiomedicine 59:102968.
O'Connor KM, Lucking EF, Cryan JF, O'Halloran KD (2020). Bugs, breathing and blood pressure: microbiota-gut-brain axis signalling in cardiorespiratory control in health and disease'. The Journal of Physiology 598(19):4159-4179.
O’Connor KM, Lucking EF, Golubeva AV, Strain CR, Fouhy F, Cenit MC, Dhaliwal P, Bastiaanssen TFS, Burns DP, Stanton C, Clarke G, Cryan JF, O’Halloran KD. (2019). Manipulation of gut microbiota blunts the ventilatory response to hypercapnia in adult rats. EBiomedicine 44, 618-638.
Lucking EF, O'Connor KM, Strain CR, Fouhy F, Bastiaanssen TF, Burns DP, Golubeva AV, Stanton C, Clarke G, Cryan JF, O'Halloran KD (2018). Chronic intermittent hypoxia disrupts cardiorespiratory homeostasis and gut microbiota composition in adult male guinea-pigs. EBiomedicine 38, 191-205.
Respiratory muscle weakness in animal models of sustained hypoxia.
Hypoxia (low oxygen) occurs at altitude and in acute and chronic respiratory diseases. We have shown that hypoxia causes redox remodelling in respiratory muscles leading to weakness. Prolonged exposure to hypoxia causes protein breakdown, atrophy and profound weakness in diaphragm and upper airway muscles. Diaphragm weakness is predictive of poor patient outcome with increased morbidity and mortality. In critically-ill patients in the ICU, mechanical ventilation, infection, and sepsis cause profound diaphragm weakness which can prolong ICU stays delaying weaning from the ventilator. Hypoxia is a feature of acute critical illness and may exacerbate respiratory muscle dysfunction. We have shown that antioxidants can ameliorate hypoxia induced respiratory muscle structural and functional remodelling, with N-acetyl cysteine, a dietary supplement, emerging as the most efficacious in studies in rodent models. Our work suggests that antioxidant strategies may have use as adjunctive therapies in the treatment of people with hypoxic respiratory disease.
Key publications:
O'Leary AJ, Drummond SE, Edge D, O'Halloran KD (2018). Diaphragm muscle weakness following acute sustained hypoxic stress in the mouse is prevented by pre-treatment with N-acetyl cysteine'. Oxidative Medicine and Cellular Longevity 2018, 4805493.
Greising SM, Ottenheijm CAC, O'Halloran KD, Barreiro E. (2018). Diaphragm plasticity in aging and disease: therapies for muscle weakness go from strength to strength'. Journal of Applied Physiology 125, 243-253.
Lewis P, O'Halloran KD (2016). Diaphragm muscle adaptation to sustained hypoxia: lessons from animal models with relevance to high altitude and chronic respiratory diseases. Frontiers in Physiology 7, 623.
Lewis P, Sheehan D, Soares R, Varela Coelho A, O'Halloran KD (2016). Redox remodeling is pivotal in murine diaphragm muscle adaptation to chronic sustained hypoxia. American Journal of Respiratory Cell and Molecular Biology 55, 12-23.
Lewis P, Sheehan D, Soares R, Coelho AV, O'Halloran KD (2015). Chronic sustained hypoxia-induced redox remodeling causes contractile dysfunction in mouse sternohyoid muscle'. Frontiers in Physiology 6, 122.
Carberry J, McMorrow C, Bradford A, Jones JFX, O'Halloran KD (2014) 'Effects of sustained hypoxia on sternohyoid and diaphragm muscle during development'. European Respiratory Journal 43,1149-1158.
McMorrow C, Fredsted A, O'Connell RA, Carberry J, Bradford A, Jones JFX, O'Halloran KD. (2011) 'Chronic hypoxia increases rat diaphragm muscle endurance and sodium-potassium ATPase pump content'. European Respiratory Journal 37, 1474-1481.
Thank you to the team!
Many colleagues have contributed to the above and many other research studies over the years. I am grateful to them for their energy and enthusiasm leading to fruitful outcomes and especially for the camaraderie along the way.
Funding.
Projects funded by the Health Research Board, Irish Research Council, Muscular Dystrophy Ireland, Duchenne Parent Project, and Science Foundation Ireland.
Collaborations:
Exercising control over runaway kynurenine pathway metabolism: Towards improved treatment outcomes in major depression.
With Dr. Jason Martin, Prof. Ted Dinan, Prof. John Cryan & Dr. Ger Clarke. Funded by the Health Research Board.
A trilogy of stressors in the NICU: Towards therapy for preterm adversity.
With Dr. Karen O'Connor, Maria Casacao & Dr. Fiona McDonald (SFI SIRG Investigator). Funded by Science Foundation Ireland.
Improving long-term patient recovery and reducing disability after COVID-19 critical illness using microRNA-based approaches.
With Dr. David Burns (UCC), Dr. Bairbre McNicholas (GUH), Prof. John Laffey (NUIG), Dr. Ronan O'Caoimh (MUH), Dr Brian McDonagh (NUIG), Dr Katarzyna Whysall (NUIG). Funded by the Health Research Board.
Gene therapy for Duchenne muscular dystrophy.
With Prof Mai ElMallah at Duke University, USA.
Research Grants
| Project | Funding Body | Start Date | End Date | Award | |
|---|---|---|---|---|---|
| INSPIRE DMD: Interventional strategies to protect and increase respiratory efficacy in Duchenne muscular dystrophy. | Science Foundation Ireland | 01-SEP-20 | 31-AUG-24 | €552,535.00 | |
| BREATHE DMD: Boosted respiratory efficacy after therapeutic hypoxic episodes in Duchenne muscular dystrophy. Funding Body: Duchenne Parent Project, The Netherlands | 01-JAN-20 | 31-DEC-21 | €70,000.00 | ||
| Improving long-term patient recovery and reducing disability after COVID-19 critical illness using microRNA-based approaches. Lead Applicant: Dr Katarzyna Whysall, NUIG | Health Research Board | 01-MAY-20 | 30-APR-22 | €199,621.00 | |
| Exercising Control over Runaway Kynurenine Pathway Metabolism: Towards Improved Treatment Outcomes in Major Depression. Lead, Dr. Ger Clarke. | Health Research Board | 01-JAN-18 | 31-DEC-20 | €369,574.00 | |
| Probing a novel glutamatergic mechanism in baroreceptor terminals to control hypertension. Lead: Guy Bewick, Aberdeen. Funded by British Heart Foundation | 01-SEP-18 | 23-OCT-19 | €95,000.00 | ||
| National Transgenic & Germ Free Facility | Science Foundation Ireland | 01-JAN-13 | 30-JUN-15 | €1,088,119.00 | |
| The efficacy and effectiveness of capnography monitoring during intravenous conscious sedation with midazolam for oral surgery. Lead: Dr Paul Brady | Health Research Board | 01-OCT-13 | 30-SEP-17 | €177,014.00 | |
| Respiratory muscle dysfunction following chronic intermittent hypoxia | Health Research Board | 01-OCT-08 | 30-SEP-13 | €235,671.00 | |
| Respiratory plasticity in an animal model of sleep-disordered breathing | Health Research Board | 01-OCT-08 | 30-SEP-11 | €219,543.00 | |
| Vascular reactivity in an animal model of sleep-disordered breathing | Irish Research Council | 01-OCT-10 | 30-SEP-13 | €72,009.00 | |
| Respiratory muscle dysfunction following chronic intermittent hypoxia | Irish Research Council | 01-OCT-08 | 30-SEP-11 | €72,009.00 | |
| Upper airway function across the age spectrum in a rodent model of sleep-disordered breathing | Health Research Board | 01-OCT-06 | 30-SEP-09 | €160,801.00 | |
| Oxycycler Environmental Oxygen Control System | Health Research Board | 01-OCT-06 | €46,643.00 | ||
| Molecular mechanisms of respiratory muscle adaptation to hypoxia | UCC Strategic Research Fund | 01-JAN-13 | 31-DEC-13 | €7,500.00 | |
| Establishing a core facility for translational studies of chronic hypoxia | UCC Strategic Research Fund | 01-OCT-13 | 30-SEP-14 | €10,878.00 | |
| Inflammation in hypoxia-induced exacerbation of respiratory muscle dysfunction in Duchenne Muscular Dystrophy | Other: Not Listed | 01-JAN-14 | 31-DEC-14 | €10,000.00 | |
| Does crosstalk between corticotropin-releasing factor and interleukin-6 underlie skeletal and smooth muscle inflammation and dysfunction in the mdx mouse model of Duchenne Muscular Dystrophy? | Other: Not Listed | 01-JAN-13 | 31-DEC-13 | €10,000.00 | |
| Hypoxic adaptation in respiratory muscle (Major & Strategic Initiative Funding, University College Dublin) | Other: Not Listed | 01-JAN-10 | 31-DEC-10 | €20,000.00 | |
| Tissue oxygen monitoring in health and disease (Commercialisation Grant, Seed Funding Programme, University College Dublin) | Other: Not Listed | 01-JAN-10 | 31-DEC-10 | €12,000.00 | |
| UCD School of Medicine & Medical Science Postgraduate Scholarship (awarded to D. Edge) | 01-OCT-11 | 30-SEP-12 | €16,000.00 | ||
| UCD School of Medicine & Medical Science Postgraduate Scholarship (awarded to F. McDonald)) | €64,000.00 | ||||
| UCD School of Medicine & Medical Science Postgraduate Scholarship (awarded to C. Shortt) | 01-OCT-07 | 30-SEP-11 | €64,000.00 | ||
| UCD Ad Astra PhD scholarship (awarded to J. R. Skelly) | 01-OCT-06 | 30-SEP-10 | €64,000.00 | ||
| School of Medicine & Medical Science Postgraduate Scholarship (awarded to J. Carberry) | 01-OCT-06 | 30-SEP-10 | €64,000.00 | ||
| Measurement of metabolism in small rodents (Seed Funding: Equipment; University College Dublin) | Other: Not Listed | 01-JAN-08 | 31-DEC-08 | €18,037.00 | |
| Does oxidative stress contribute to upper airway dilator muscle dysfunction following chronic intermittent hypoxia? | Health Research Board | 01-OCT-05 | 30-SEP-06 | €14,888.00 | |
| Vascular dysfunction in a rodent model of sleep apnoea | 01-JAN-07 | 31-DEC-07 | €6,500.00 |
Publications
Peer Reviewed Journals
| Year | Publication | |
|---|---|---|
| (2024) | 'Machine Learning Models of Cerebral Oxygenation (rcSO2) for Brain Injury Detection in Neonates with Hypoxic-Ischaemic Encephalopathy' Minoo Ashoori, John M. O'Toole, Aisling A. Garvey, Ken D O'Halloran, Brian H. Walsh, Michael Moore, Andreea M. Pavel, Geraldine Boylan, Deirdre Murray, Eugene Dempsey, and Fiona B McDonald (2024) 'Machine Learning Models of Cerebral Oxygenation (rcSO2) for Brain Injury Detection in Neonates with Hypoxic-Ischaemic Encephalopathy'. The Journal of Physiology, [Details] | |
| (2024) | 'Impaired upper airway muscle function with excessive or deficient dietary intake of selenium in the rat' David P. Burns, Sarah E. Drummond, Stefanie Wölfel, Kevin H. Murphy, Joanna Szpunar, Ken D. O'Halloran, John J. Mackrill (2024) 'Impaired upper airway muscle function with excessive or deficient dietary intake of selenium in the rat'. Antioxidants (Basel, Switzerland), [Details] | |
| (2024) | 'Refinement in animal experimentation: Calling time on the use of chloral hydrate for non-recovery procedures and euthanasia' O'Halloran KD (2024) 'Refinement in animal experimentation: Calling time on the use of chloral hydrate for non-recovery procedures and euthanasia'. The Journal of Physiology, [Details] | |
| (2024) | 'Champions of the mountains: superior aerobic performance in Tibetans is not due to enhanced cardiopulmonary traits' Murphy BT, O'Halloran KD (2024) 'Champions of the mountains: superior aerobic performance in Tibetans is not due to enhanced cardiopulmonary traits'. The Journal of Physiology, [Details] | |
| (2024) | 'Intermittent hypoxia therapy for motor insufficiency: hype, hope or hard work?' O'Halloran KD (2024) 'Intermittent hypoxia therapy for motor insufficiency: hype, hope or hard work?'. The Journal of Physiology, [Details] | |
| (2024) | 'Respiratory performance in Duchenne muscular dystrophy: Clinical manifestations and lessons from animal models' Delaney R, O'Halloran KD (2024) 'Respiratory performance in Duchenne muscular dystrophy: Clinical manifestations and lessons from animal models'. Experimental Physiology, [Details] | |
| (2024) | 'Mouth taping: A little less conversation, a little more action, please!' O'Halloran KD (2024) 'Mouth taping: A little less conversation, a little more action, please!'. The Journal of Physiology, [Details] | |
| (2024) | 'BREATHE DMD: Boosting Respiratory Efficacy After Therapeutic Hypoxic Episodes in Duchenne Muscular Dystrophy' Seán C Ó Murchú and Ken D. O'Halloran (2024) 'BREATHE DMD: Boosting Respiratory Efficacy After Therapeutic Hypoxic Episodes in Duchenne Muscular Dystrophy'. The Journal of Physiology, [Details] | |
| (2024) | 'Chronic N-acetyl cysteine treatment does not improve respiratory system performance in the mdx mouse model of Duchenne muscular dystrophy' Michael N Maxwell, Anthony L Marullo, Esther Valverde-Pérez, Aoife D Slyne, Ben T Murphy and Ken D. O'Halloran (2024) 'Chronic N-acetyl cysteine treatment does not improve respiratory system performance in the mdx mouse model of Duchenne muscular dystrophy'. Experimental Physiology, [Details] | |
| (2024) | 'Using Modified Fenn Diagrams to Assess Ventilatory Acclimatization During Ascent to High Altitude - Effect of Acetazolamide' Rodion Isakovich, Valerie C Cates, Brandon Pentz, Jordan D. Bird, Emily R Vanden Berg, Emily M de Freitas, Cassandra E. Nysten, Jack K. Leacy, Ken D. O'Halloran, Tom D Brutsaert, Mingma T. Sherpa, and Trevor A. Day (2024) 'Using Modified Fenn Diagrams to Assess Ventilatory Acclimatization During Ascent to High Altitude - Effect of Acetazolamide'. Experimental Physiology, [Details] | |
| (2024) | 'SubSol HIe is an AMPK-dependent hypoxia responsive subnucleus of the nucleus tractus solitarius that coordinates the hypoxic ventilatory response and protects against apnoea in mice' MacMillan S, Burns DP, O'Halloran KD, Evans AM (2024) 'SubSol HIe is an AMPK-dependent hypoxia responsive subnucleus of the nucleus tractus solitarius that coordinates the hypoxic ventilatory response and protects against apnoea in mice'. Pflugers Archiv-European Journal Of Physiology, [Details] | |
| (2024) | 'Effects of intrarenal pelvic infusion of tumour necrosis factor-α and interleukin 1-β on reno-renal reflexes in anaesthetised rats' Mohammed H. Abdulla, Sara AlMarabeh, Tom Bolger, Eric F. Lucking, Ken D. O’Halloran and Edward J. Johns (2024) 'Effects of intrarenal pelvic infusion of tumour necrosis factor-α and interleukin 1-β on reno-renal reflexes in anaesthetised rats'. Journal of Hypertension, [Details] | |
| (2024) | 'Update on requirements for ethics and welfare reporting in The Journal of Physiology' O'Halloran KD (2024) 'Update on requirements for ethics and welfare reporting in The Journal of Physiology'. The Journal of Physiology, [Details] | |
| (2024) | 'Divorce proceedings: Uncoupling of genioglossus EMG activity and regional tongue movement in humans with and without sleep apnoea' O'Halloran KD (2024) 'Divorce proceedings: Uncoupling of genioglossus EMG activity and regional tongue movement in humans with and without sleep apnoea'. The Journal of Physiology, [Details] | |
| (2023) | 'Chronic intermittent hypoxia-induced cardiovascular and renal dysfunction: from adaptation to maladaptation' Claire Arnaud, Emma Billoir, Antonio F. de Melo Junior, Sofia A. Pereira, Ken D. O’Halloran and Emilia C. Monteiro (2023) 'Chronic intermittent hypoxia-induced cardiovascular and renal dysfunction: from adaptation to maladaptation'. The Journal of Physiology, [Details] | |
| (2023) | 'Pump up the volume: Breathing facilitates cardiac output during exercise by mechanical action' O'Halloran KD (2023) 'Pump up the volume: Breathing facilitates cardiac output during exercise by mechanical action'. The Journal of Physiology, [Details] | |
| (2023) | 'Hypoxic sensitivity and burden predict propensity for respiratory plasticity in humans' O'Halloran KD (2023) 'Hypoxic sensitivity and burden predict propensity for respiratory plasticity in humans'. The Journal of Physiology, [Details] | |
| (2023) | 'Stress-induced cardiovascular morbidity: Past, present, and future' Slyne AD, McDonald FB, O'Halloran KD (2023) 'Stress-induced cardiovascular morbidity: Past, present, and future'. Experimental Physiology, [Details] | |
| (2023) | 'Loss of compensation afforded by accessory muscles of breathing leads to respiratory system compromise in the mdx mouse model of Duchenne muscular dystrophy' Ken D O'Halloran, Michael N Maxwell, Anthony L Marullo, Chantelle P Hamilton, Seán C Ó Murchú, David P Burns, Conor M Mahony, Aoife D Slyne, and Sarah E Drummond (2023) 'Loss of compensation afforded by accessory muscles of breathing leads to respiratory system compromise in the mdx mouse model of Duchenne muscular dystrophy'. The Journal of Physiology, [Details] | |
| (2023) | 'Chronic intermittent hypoxia-induced diaphragm muscle weakness is NADPH oxidase-2 dependent' Sarah E. Drummond, David P. Burns, Sarah El Maghrani, Oscar Ziegler, Vincent Healy, Ken D. O'Halloran (2023) 'Chronic intermittent hypoxia-induced diaphragm muscle weakness is NADPH oxidase-2 dependent'. Cells, [Details] | |
| (2023) | 'Machine Learning Detects Intraventricular Haemorrhage in Extremely Preterm Infants' Minoo Ashoori, John M. O'Toole, Ken D. O'Halloran, Gunnar Naulaers, Liesbeth Thewissen, Jan Miletin, Po-Yin Cheung, Afif El-Khuffash, David Van Laere, Zbyněk Straňák, Eugene M. Dempsey, Fiona B. McDonald (2023) 'Machine Learning Detects Intraventricular Haemorrhage in Extremely Preterm Infants'. Children, [Details] | |
| (2023) | 'Ventilatory effects of acute intermittent hypoxia in conscious dystrophic mice' Maxwell MN, Marullo AL, Slyne AD, Lucking EF, O'Halloran KD (2023) 'Ventilatory effects of acute intermittent hypoxia in conscious dystrophic mice'. Advances In Experimental Medicine and Biology, [Details] | |
| (2023) | 'Three days of chronic intermittent hypoxia induce B1-adrenoceptor dependent increases in left ventricular contractility' Marullo AL, Lucking EF, Pender D, Dhaliwal P, O'Halloran KD (2023) 'Three days of chronic intermittent hypoxia induce B1-adrenoceptor dependent increases in left ventricular contractility'. Advances In Experimental Medicine and Biology, [Details] | |
| (2023) | 'Microbes, metabolites and muscle: Is the gut-muscle axis a plausible therapeutic target in Duchenne muscular dystrophy?' Marullo AL and O'Halloran KD (2023) 'Microbes, metabolites and muscle: Is the gut-muscle axis a plausible therapeutic target in Duchenne muscular dystrophy?'. Experimental Physiology, [Details] | |
| (2023) | 'Regenerating interest in pharmacotherapy for spinal cord injury' Slyne AD, O'Halloran KD (2023) 'Regenerating interest in pharmacotherapy for spinal cord injury'. The Journal of Physiology, [Details] | |
| (2023) | 'Strength in breath: respiratory metaboreflex response to training and detraining' Murphy BT, O'Halloran KD (2023) 'Strength in breath: respiratory metaboreflex response to training and detraining'. Experimental Physiology, [Details] | |
| (2023) | 'Potentiated respiratory metaboreflex in older males and females: afferent or efferent mechanisms?' O'Halloran KD (2023) 'Potentiated respiratory metaboreflex in older males and females: afferent or efferent mechanisms?'. The Journal of Physiology, [Details] | |
| (2023) | 'Making sense of the carotid body counter-regulatory response to hypoglycaemia' Slyne AD, O'Halloran KD (2023) 'Making sense of the carotid body counter-regulatory response to hypoglycaemia'. Experimental Physiology, [Details] | |
| (2023) | 'Alcohol and airway calibre: Does motor or muscle depression contribute to increased likelihood of obstruction?' Maxwell MN and O'Halloran KD (2023) 'Alcohol and airway calibre: Does motor or muscle depression contribute to increased likelihood of obstruction?'. Experimental Physiology, [Details] | |
| (2022) | 'Steady-state chemoreflex drive captures ventilatory acclimatization during incremental ascent to high altitude: Effect of acetazolamide' Cates VC, Bruce CD, Marullo AL, Isakovich R, Saran G, Leacy JK, O Halloran KD, Brutsaert TD, Sherpa MT, Day TA (2022) 'Steady-state chemoreflex drive captures ventilatory acclimatization during incremental ascent to high altitude: Effect of acetazolamide'. Physiological reports, [Details] | |
| (2022) | 'Impact of cancer cachexia on respiratory muscle function and the therapeutic potential of exercise' Ben T Murphy, John J Mackrill & Ken D O'Halloran (2022) 'Impact of cancer cachexia on respiratory muscle function and the therapeutic potential of exercise'. The Journal of Physiology, [Details] | |
| (2022) | 'Cardiorespiratory consequences of obesity: A tale of two pumps' Marullo AL, O'Halloran KD (2022) 'Cardiorespiratory consequences of obesity: A tale of two pumps'. Experimental Physiology, [Details] | |
| (2022) | 'Breathing new life into therapies for Duchenne muscular dystrophy' O'Halloran KD (2022) 'Breathing new life into therapies for Duchenne muscular dystrophy'. The Journal of Physiology, [Details] | |
| (2022) | 'Variation within the visually evoked neurovascular coupling response of the posterior cerebral artery is not influenced by age or sex' Jack K. Leacy, Emily M. Johnson, Lauren R. Lavoie, Diane N. Macilwraith, Megan Bambury, Jason A. Martin, Eric F. Lucking, Andrea M. Linares, Gurkarn Saran, Dwayne P. Sheehan, Nishan Sharma, Trevor A. Day, Ken D. O’Halloran (2022) 'Variation within the visually evoked neurovascular coupling response of the posterior cerebral artery is not influenced by age or sex'. Journal of Applied Physiology, [Details] | |
| (2022) | 'NADPH oxidase-2 is necessary for chronic intermittent hypoxia-induced sternohyoid muscle weakness in adult male mice' Sarah E. Drummond, David P. Burns, Sarah El Maghrani, Oscar Ziegler, Vincent Healy, and Ken D. O'Halloran (2022) 'NADPH oxidase-2 is necessary for chronic intermittent hypoxia-induced sternohyoid muscle weakness in adult male mice'. Experimental Physiology, [Details] | |
| (2022) | 'Breathing in Duchenne muscular dystrophy: Translation to therapy' Mhandire DZ, Burns DP, Roger AL, O'Halloran KD, ElMallah MK (2022) 'Breathing in Duchenne muscular dystrophy: Translation to therapy'. The Journal of Physiology, [Details] | |
| (2022) | 'A shock to the system: neurostimulation therapy for opioid-induced respiratory depression' O'Halloran KD (2022) 'A shock to the system: neurostimulation therapy for opioid-induced respiratory depression'. The Journal of Physiology, [Details] | |
| (2022) | 'Clever approaches to intriguing questions: halcyon days of carotid body research by one of the best' O'Halloran KD (2022) 'Clever approaches to intriguing questions: halcyon days of carotid body research by one of the best'. The Journal of Physiology, [Details] | |
| (2022) | 'The ups and downs of intermittent hypoxia as a therapy for ventilatory insufficiency' O'Halloran KD (2022) 'The ups and downs of intermittent hypoxia as a therapy for ventilatory insufficiency'. The Journal of Physiology, [Details] | |
| (2022) | 'Keep in touch: Nodal connectivity in the control of breathing and blood pressure' O'Halloran KD (2022) 'Keep in touch: Nodal connectivity in the control of breathing and blood pressure'. Experimental Physiology, [Details] | |
| (2021) | 'Targeting the toll-like receptor pathway as a therapeutic strategy for neonatal infection' Dias ML, O'Connor KM, Dempsey EM, O'Halloran KD, McDonald FB (2021) 'Targeting the toll-like receptor pathway as a therapeutic strategy for neonatal infection'. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, [Details] | |
| (2021) | 'Intra-renal pelvic bradykinin-induced sympathoexcitatory reno-renal reflex is attenuated in rats exposed to chronic intermittent hypoxia' AlMarabeh S, Lucking EF, O'Halloran KD & Abdulla MH (2021) 'Intra-renal pelvic bradykinin-induced sympathoexcitatory reno-renal reflex is attenuated in rats exposed to chronic intermittent hypoxia'. Journal of Hypertension, [Details] | |
| (2021) | 'Microbiota and sleep: Awakening the gut feeling' Sen P, Molinero-Perez A, O'Riordan KJ, McCafferty CP, O'Halloran KD, Cryan JF. (2021) 'Microbiota and sleep: Awakening the gut feeling'. Trends Mol Medtrends Mol Med, [Details] | |
| (2021) | 'One step closer to pharmacotherapy for sleep apnoea' O'Halloran KD (2021) 'One step closer to pharmacotherapy for sleep apnoea'. The Journal of Physiology, [Details] | |
| (2021) | 'The Effects of Acute Incremental Hypocapnia on the Magnitude of Neurovascular Coupling in Healthy Participants' Taylor J Bader, Jack K. Leacy, Joanna RG Keough, Anna-Maria Ciorogariu-Ivan, Joshua R Donald, Anthony L Marullo, Ken D. O'Halloran, Nicholas G Jendzjowsky, Richard J.A. Wilson, and Trevor A. Day (2021) 'The Effects of Acute Incremental Hypocapnia on the Magnitude of Neurovascular Coupling in Healthy Participants'. Physiological reports, [Details] | |
| (2021) | 'Endogenous medullary raphé hydrogen sulphide facilitates the ventilatory response to hypercapnia' Condon-English FJ and O'Halloran KD (2021) 'Endogenous medullary raphé hydrogen sulphide facilitates the ventilatory response to hypercapnia'. Experimental Physiology, [Details] | |
| (2021) | 'The role of NADPH oxidase in chronic intermittent hypoxia-induced respiratory plasticity in adult male mice' Drummond SE, Burns DP, O'Connor KM, Clarke G, O'Halloran KD (2021) 'The role of NADPH oxidase in chronic intermittent hypoxia-induced respiratory plasticity in adult male mice'. Respiratory Physiology & Neurobiology, [Details] | |
| (2021) | 'Influence of innate immune activation on endocrine and metabolic pathways in infancy' O'Connor KM, Ashoori M, Dias M, Dempsey EM, O'Halloran KD, McDonald FB (2021) 'Influence of innate immune activation on endocrine and metabolic pathways in infancy'. American Journal of Physiology (Endocrinology and Metabolism), [Details] | |
| (2021) | 'The effect of exercise interventions on inflammatory markers in major depressive disorder: protocol for a systematic review and meta-analysis' Grunberg D, Martin JA, Cryan JF, O’Halloran KD, Kelleher E, Dinan TG and Clarke G (2021) 'The effect of exercise interventions on inflammatory markers in major depressive disorder: protocol for a systematic review and meta-analysis'. Hrb Open Research, [Details] | |
| (2021) | 'Re-evaluating the oxidative phenotype: Can endurance exercise save the Western world?' Kolodziej F, O'Halloran KD (2021) 'Re-evaluating the oxidative phenotype: Can endurance exercise save the Western world?'. Antioxidants (Basel, Switzerland), [Details] | |
| (2021) | 'Time Course and Magnitude of Ventilatory and Renal Acid-Base Acclimatization Following Rapid Ascent to and Residence at 3,800 m over Nine Days' Jordan Bird, Jack Leacy, Glen Foster, Caroline Rickards, Richard Wilson, Ken O'Halloran, Nicholas Jendzjowsky, Brandon Pentz, Britta Byman, Scott Thrall, Alexandra Skalk, Sarah Hewitt, Craig Steinback, David Burns, Peter Ondrus, and Trevor Day (2021) 'Time Course and Magnitude of Ventilatory and Renal Acid-Base Acclimatization Following Rapid Ascent to and Residence at 3,800 m over Nine Days'. Journal of Applied Physiology, [Details] | |
| (2021) | 'Ascending the gut-brain axis: Does the microbiome affect acclimatization to high altitude?' Anthony L Marullo, Jack K Leacy, Ken D O'Halloran & Trevor A Day (2021) 'Ascending the gut-brain axis: Does the microbiome affect acclimatization to high altitude?'. Experimental Physiology, [Details] | |
| (2020) | 'Diaphragm fatigue: Similarities and differences between sexes' O'Halloran KD (2020) 'Diaphragm fatigue: Similarities and differences between sexes'. The Journal of Physiology, [Details] | |
| (2020) | 'Muscling in on neurorehabilitative strategies to counter respiratory motor dysfunction in cervical spinal cord injury' O'Halloran KD (2020) 'Muscling in on neurorehabilitative strategies to counter respiratory motor dysfunction in cervical spinal cord injury'. The Journal of Physiology, [Details] | |
| (2020) | 'Chronic intermittent hypoxia impairs diuretic and natriuretic responses to volume expansion in rats with preserved low-pressure baroreflex control of the kidney' AlMarabeh S, O'Neill J, Cavers J, Lucking EF, O'Halloran KD, Abdulla MH (2020) 'Chronic intermittent hypoxia impairs diuretic and natriuretic responses to volume expansion in rats with preserved low-pressure baroreflex control of the kidney'. American Journal of Physiology (Renal), [Details] | |
| (2020) | 'Stimulating ideas for disorders of breathing, speech and swallowing' O'Halloran KD (2020) 'Stimulating ideas for disorders of breathing, speech and swallowing'. The Journal of Physiology, [Details] | |
| (2020) | 'Prebiotic administration modulates gut microbiota and faecal short-chain fatty acid concentrations but does not prevent chronic intermittent hypoxia-induced apnoea and hypertension in adult rats' O’Connor KM, Lucking EF, Bastiaanssen TFS, Peterson VL, Crispie F, Cotter PD, Clarke G, Cryan JF, O’Halloran KD (2020) 'Prebiotic administration modulates gut microbiota and faecal short-chain fatty acid concentrations but does not prevent chronic intermittent hypoxia-induced apnoea and hypertension in adult rats'. Ebiomedicine, [Details] | |
| (2020) | 'Bugs, breathing and blood pressure: Microbiota-gut-brain axis signalling in cardiorespiratory control in health and disease' O'Connor KM, Lucking EF, Cryan JF & O'Halloran KD (2020) 'Bugs, breathing and blood pressure: Microbiota-gut-brain axis signalling in cardiorespiratory control in health and disease'. The Journal of Physiology, [Details] | |
| (2020) | 'Renal physiological adaptation to high altitude: A systematic review' Palubiski LM, O'Halloran KD, O'Neill J (2020) 'Renal physiological adaptation to high altitude: A systematic review'. Frontiers in Physiology, [Details] | |
| (2020) | 'The carotid bodies exercise control over active expiration but not peak performance during high-intensity treadmill running' Kolodziej F, O'Halloran KD (2020) 'The carotid bodies exercise control over active expiration but not peak performance during high-intensity treadmill running'. Experimental Physiology, [Details] | |
| (2020) | 'Cardiorespiratory hysteresis during incremental high altitude ascent-descent quantifies the magnitude of ventilatory acclimatization' Jack K. Leacy, Andrea M. Linares, Shaelynn M. Zouboules, Zahrah H. Rampuri, Jordan D. Bird, Brittney A. Herrington, Leah Mann, Jan E. Soriano, Scott F. Thrall, Anne Kalker, Tom Brutsaert, Ken D. O'Halloran, Mingma T. Sherpa, Trevor A. Day (2020) 'Cardiorespiratory hysteresis during incremental high altitude ascent-descent quantifies the magnitude of ventilatory acclimatization'. Experimental Physiology, [Details] | |
| (2020) | 'Mind the gap: Widening the demographic to define new norms in human physiology' O'Halloran KD (2020) 'Mind the gap: Widening the demographic to define new norms in human physiology'. The Journal of Physiology, [Details] | |
| (2020) | 'Simulating the space station: A launch pad for new explorations in integrative physiology' Leacy JK, O'Halloran KD, Day TA (2020) 'Simulating the space station: A launch pad for new explorations in integrative physiology'. The Journal of Physiology, [Details] | |
| (2020) | 'Progesterone is a promising therapeutic for the prevention of apnoea' McDonald FB, O'Connor KM, O'Halloran KD (2020) 'Progesterone is a promising therapeutic for the prevention of apnoea'. Experimental Physiology, [Details] | |
| (2020) | 'Diaphragm remodelling following cervical spinal cord injury in humans: Can intrinsic neural plasticity be harnessed to improve respiratory motor function?' O'Halloran KD, Smith BK (2020) 'Diaphragm remodelling following cervical spinal cord injury in humans: Can intrinsic neural plasticity be harnessed to improve respiratory motor function?'. The Journal of Physiology, [Details] | |
| (2020) | 'Ventilatory acclimatization to hypoxia: Time to express a critical central message' O'Halloran KD (2020) 'Ventilatory acclimatization to hypoxia: Time to express a critical central message'. The Journal of Physiology, [Details] | |
| (2020) | 'Unravelling the role of interleukin-11 in renal and cardiac fibrosis in malignant hypertension' Abdulla MH & O'Halloran KD (2020) 'Unravelling the role of interleukin-11 in renal and cardiac fibrosis in malignant hypertension'. American Journal of Hypertension, [Details] | |
| (2020) | 'A tongue-twister to translation? Increased complexity of genioglossus movement during wakefulness in persons with obstructive sleep apnoea' O'Halloran KD (2020) 'A tongue-twister to translation? Increased complexity of genioglossus movement during wakefulness in persons with obstructive sleep apnoea'. The Journal of Physiology, [Details] | |
| (2019) | 'The two faces of active expiration: A case of mistaken identity!' O'Connor KM, Lucking EF, O'Halloran KD (2019) 'The two faces of active expiration: A case of mistaken identity!'. Experimental Physiology, [Details] | |
| (2019) | 'Corticomotor control of airway calibre in obstructive sleep apnoea syndrome' Leacy JK, O'Halloran KD (2019) 'Corticomotor control of airway calibre in obstructive sleep apnoea syndrome'. Experimental Physiology, [Details] | |
| (2019) | 'Pontine noradrenergic neurons facilitate pulmonary ventilation during hypercapnic stress: Fight or flight,---and breathe!' O'Halloran KD (2019) 'Pontine noradrenergic neurons facilitate pulmonary ventilation during hypercapnic stress: Fight or flight,---and breathe!'. Experimental Physiology, [Details] | |
| (2019) | 'N-acetylcysteine decreases fibrosis and increases force-generating capacity of mdx diaphragm' Burns DP, Drummond SE, Bolger D, Coiscaud A, Murphy KH, Edge D, O'Halloran KD (2019) 'N-acetylcysteine decreases fibrosis and increases force-generating capacity of mdx diaphragm'. Antioxidants (Basel, Switzerland), [Details] | |
| (2019) | 'Carbonic anhydrase inhibition and chemoreflex control of breathing: A litmus test for methazolamide as a viable alternative to acetazolamide' Leacy JK, Day TA, O'Halloran TD (2019) 'Carbonic anhydrase inhibition and chemoreflex control of breathing: A litmus test for methazolamide as a viable alternative to acetazolamide'. Experimental Physiology, [Details] | |
| (2019) | 'Epigenetic silencing by early life hypoxic stress programmes respiratory motor control' O’Connor, Karen M.; Dias, Maria L.; McDonald, Fiona B.; O’Halloran, Ken D. (2019) 'Epigenetic silencing by early life hypoxic stress programmes respiratory motor control'. Experimental Physiology, [DOI] [Full Text] [Details] | |
| (2019) | 'The impact of preterm adversity on cardiorespiratory function' McDonald FB, Dempsey EM & O'Halloran KD (2019) 'The impact of preterm adversity on cardiorespiratory function'. Experimental Physiology, [Details] | |
| (2019) | 'Working out the energetic cost of breathing during exercise' O'Halloran (2019) 'Working out the energetic cost of breathing during exercise'. Experimental Physiology, [Details] | |
| (2019) | 'Motor unit behaviour of the ageing human diaphragm: Mid-life crisis for the inspiratory pump?' O'Halloran KD (2019) 'Motor unit behaviour of the ageing human diaphragm: Mid-life crisis for the inspiratory pump?'. The Journal of Physiology, [Details] | |
| (2019) | 'Brainstem adrenomedullin facilitates intermittent hypoxia-induced hypertension: A sympathetic story of a selfish brain' Abdulla MH, O'Halloran KD (2019) 'Brainstem adrenomedullin facilitates intermittent hypoxia-induced hypertension: A sympathetic story of a selfish brain'. Experimental Physiology, [Details] | |
| (2019) | 'Opioids for the relief of acute respiratory distress syndrome: Endomorphins are the μ kids on the block!' Lucking EF, O'Halloran KD (2019) 'Opioids for the relief of acute respiratory distress syndrome: Endomorphins are the μ kids on the block!'. Experimental Physiology, [Details] | |
| (2019) | 'Auxiliary compensation for diaphragm dysfunction in dystrophic disease' Burns DP, Lucking EF, O'Halloran KD (2019) 'Auxiliary compensation for diaphragm dysfunction in dystrophic disease'. The Journal of Physiology, 597 (15):4103-4105 [Details] | |
| (2019) | 'Is alkalosis the dominant factor in hypoxia-induced cognitive dysfunction?' Leacy JK, Day TA, O'Halloran KD (2019) 'Is alkalosis the dominant factor in hypoxia-induced cognitive dysfunction?'. Experimental Physiology, [Details] | |
| (2019) | 'The hypoxic ventilatory response: Is continued debate redundant? (In: Comments on Cross-Talk Debate 38)' O'Halloran KD (2019) 'The hypoxic ventilatory response: Is continued debate redundant? (In: Comments on Cross-Talk Debate 38)'. The Journal of Physiology, [Details] | |
| (2019) | 'Chronic intermittent hypoxia induced hypertension: An expired hypothesis laid to rest?' O'Connor KM, Lucking EF, O'Halloran KD (2019) 'Chronic intermittent hypoxia induced hypertension: An expired hypothesis laid to rest?'. Experimental Physiology, [Details] | |
| (2019) | 'Is aberrant reno-renal reflex control of blood pressure a contributor to chronic intermittent hypoxia-induced hypertension?' AlMarabeh S, Abdullah MA, O'Halloran KD (2019) 'Is aberrant reno-renal reflex control of blood pressure a contributor to chronic intermittent hypoxia-induced hypertension?'. Frontiers in Physiology, [Details] | |
| (2019) | 'Diaphragm muscle performance in ageing: A new perspective on an old story' Burns DP, O'Halloran KD (2019) 'Diaphragm muscle performance in ageing: A new perspective on an old story'. Experimental Physiology, [Details] | |
| (2019) | 'Cycle ergometer training enhances plasma interleukin-10 in multiple sclerosis' Barry, Alison; Cronin, Owen; Ryan, Aisling M.; Sweeney, Brian; O’Toole, Orna; O’Halloran, Ken D.; Downer, Eric J. (2019) 'Cycle ergometer training enhances plasma interleukin-10 in multiple sclerosis'. Neurological Sciences, [DOI] [Full Text] [Details] | |
| (2019) | 'Cortical control of upper airway calibre: It's the thought that counts!' Leacy JK, O'Halloran KD (2019) 'Cortical control of upper airway calibre: It's the thought that counts!'. Experimental Physiology, [Details] | |
| (2019) | 'Is non-normalized chest wall electromyogram activity a reliable index of respiratory neural drive? On the surface---yes!' Burns DP, O'Halloran KD (2019) 'Is non-normalized chest wall electromyogram activity a reliable index of respiratory neural drive? On the surface---yes!'. Experimental Physiology, [Details] | |
| (2019) | 'Manipulation of gut microbiota blunts the ventilatory response to hypercapnia in adult rats' Karen M. O’Connor, Eric F. Lucking, Anna V. Golubeva, Conall R. Strain, Fiona Fouhy, María C. Cenit, Pardeep Dhaliwal,Thomaz F.S. Bastiaanssen, David P. Burns, Catherine Stanton, Gerard Clarke, John F. Cryan, Ken D. O’Halloran. (2019) 'Manipulation of gut microbiota blunts the ventilatory response to hypercapnia in adult rats'. Ebiomedicine, [Details] | |
| (2019) | 'Peripheral and central respiratory system pathology in a mouse model of Parkinson's disease: A prodromal signature of clinical relevance?' Lucking EF, O'Halloran KD (2019) 'Peripheral and central respiratory system pathology in a mouse model of Parkinson's disease: A prodromal signature of clinical relevance?'. Experimental Physiology, [Details] | |
| (2019) | 'Renal cortical oxygen tension is decreased following exposure to long-term but not short-term intermittent hypoxia in the rat' O'Neill, Julie; Jasionek, Greg; Drummond, Sarah E.; Brett, Orla; Lucking, Eric F.; Abdulla, Mohammed A.; O'Halloran, Ken D. (2019) 'Renal cortical oxygen tension is decreased following exposure to long-term but not short-term intermittent hypoxia in the rat'. American Journal of Physiology (Renal), [DOI] [Full Text] [Details] | |
| (2019) | 'Inspiratory pressure-generating capacity is preserved during ventilatory and non-ventilatory behaviours in young dystrophic mdx mice despite profound diaphragm muscle weakness' Burns, David P; Murphy, Kevin H; Lucking Eric F.; O'Halloran Ken D. (2019) 'Inspiratory pressure-generating capacity is preserved during ventilatory and non-ventilatory behaviours in young dystrophic mdx mice despite profound diaphragm muscle weakness'. The Journal of Physiology, [DOI] [Full Text] [Details] | |
| (2019) | 'Blood flow to limb muscles during submaximal dynamic exercise with resistive breathing: Use it or lose it?' O'Halloran KD (2019) 'Blood flow to limb muscles during submaximal dynamic exercise with resistive breathing: Use it or lose it?'. Experimental Physiology, [Details] | |
| (2018) | 'Neurovascular coupling remains intact during incremental ascent to high altitude (4240m) in acclimatized healthy volunteers' Jack K. Leacy, Shaelynn M. Zouboules, Carli R. Mann, Joel D.B. Peltonen, Gurkan Saran, Cassandra E. Nysten, Heidi E. Nysten, Tom D. Brutsaert, Ken D. O’Halloran, Mingma T. Sherpa, Trevor A. Day (2018) 'Neurovascular coupling remains intact during incremental ascent to high altitude (4240m) in acclimatized healthy volunteers'. Frontiers in Physiology, [Details] | |
| (2018) | 'Chronic intermittent hypoxia disrupts cardiorespiratory homeostasis and gut microbiota composition in adult male guinea-pigs' *Lucking EF, *O'Connor KM, Strain CR, Fouhy F, Bastiaanssen TF, Burns DP, Golubeva AV, Stanton C, Clarke G, Cryan JF, O'Halloran KD (2018) 'Chronic intermittent hypoxia disrupts cardiorespiratory homeostasis and gut microbiota composition in adult male guinea-pigs'. Ebiomedicine, [Details] | |
| (2018) | 'What Is the Point of the Peak? Assessing Steady-State Respiratory Chemoreflex Drive in High Altitude Field Studies' Bruce CD, Saran G, Pfoh JR, Leacy JK, Zouboules SM, Mann CR, Peltonen JDB, Linares AM, Chiew AE, O'Halloran KD, Sherpa MT, Day TA. (2018) 'What Is the Point of the Peak? Assessing Steady-State Respiratory Chemoreflex Drive in High Altitude Field Studies'. Advances In Experimental Medicine and Biology, 1071 :13-23 [Details] | |
| (2018) | 'Genioglossus activation during maximal sniff manoeuvres: Is upper airway function relevant in the clinical assessment of inspiratory and expiratory muscle strength?' David P Burns & Ken D O'Halloran (2018) 'Genioglossus activation during maximal sniff manoeuvres: Is upper airway function relevant in the clinical assessment of inspiratory and expiratory muscle strength?'. Experimental Physiology, [Details] | |
| (2018) | 'Purinergic modulation of chemosensory drive to breathe from the lateral hypothalamus/perifornical area depends upon sleep-wake and light-dark phases' Burns DP, O'Halloran KD (2018) 'Purinergic modulation of chemosensory drive to breathe from the lateral hypothalamus/perifornical area depends upon sleep-wake and light-dark phases'. Experimental Physiology, [Details] | |
| (2018) | 'Renal reactivity: Acid-base compensation during incremental ascent to high altitude' Shaelynn M Zouboules, Hailey C Lafave, Ken D O'Halloran, Tom Brutsaert, Heidi E Nysten, Cassandra E Nysten, Craig D Steinback, Mingma T Sherpa , Trevor A Day (2018) 'Renal reactivity: Acid-base compensation during incremental ascent to high altitude'. The Journal of Physiology, [Details] | |
| (2018) | 'Recovery of respiratory function in mdx mice co-treated with neutralizing interleukin-6 receptor antibodies and Urocortin-2' Burns, David P.; Canavan, Leonie; Rowland, Jane; O'Flaherty, Robin; Brannock, Molly; Drummond, Sarah E.; O'Malley, Dervla; Edge, Deirdre; O'Halloran Ken D. (2018) 'Recovery of respiratory function in mdx mice co-treated with neutralizing interleukin-6 receptor antibodies and Urocortin-2'. The Journal of Physiology, [DOI] [Full Text] [Details] | |
| (2018) | 'Brainstem network pathology and impaired respiratory drive as successive signatures in a rat model of Parkinson's disease' Burns, David P.; O'Halloran, Ken D. (2018) 'Brainstem network pathology and impaired respiratory drive as successive signatures in a rat model of Parkinson's disease'. Experimental Physiology, 103 (10):1300-1301 [DOI] [Full Text] [Details] | |
| (2018) | 'Cardiovascular sequelae of the sleep apnoea syndrome: sex, stress and therapeutic strategies' O'Halloran, Ken D. (2018) 'Cardiovascular sequelae of the sleep apnoea syndrome: sex, stress and therapeutic strategies'. Acta Physiologica, 225 [DOI] [Full Text] [Details] | |
| (2018) | 'Caffeine therapy for apnoea of prematurity: Wake up to the fact that sex matters' McDonald, Fiona B.; Dempsey, Eugene M.; O'Halloran, Ken D. (2018) 'Caffeine therapy for apnoea of prematurity: Wake up to the fact that sex matters'. Experimental Physiology, 103 (10):1294-1295 [DOI] [Full Text] [Details] | |
| (2018) | 'The shape of things to come: early life stress stunts brainstem microglia with lasting implications for cardiorespiratory control and plasticity' O'Halloran, Ken D.; McDonald, Fiona B. (2018) 'The shape of things to come: early life stress stunts brainstem microglia with lasting implications for cardiorespiratory control and plasticity'. Experimental Physiology, 103 (9):1183-1184 [DOI] [Full Text] [Details] | |
| (2018) | 'No evidence in support of a prodromal respiratory control signature in the TgF344-AD rat model of Alzheimer’s disease' Lucking EF, Murphy KH, Burns DP, Jaisimha AV, Barry-Murphy KJ, Dhaliwal P, Boland B, Rae MG, O’Halloran KD (2018) 'No evidence in support of a prodromal respiratory control signature in the TgF344-AD rat model of Alzheimer’s disease'. Respiratory Physiology & Neurobiology, [Details] | |
| (2018) | 'Breathing with neuromuscular disease: Does compensatory plasticity in the motor drive to breathe offer a potential therapeutic target in muscular dystrophy?' O'Halloran KD, Burns DP (2018) 'Breathing with neuromuscular disease: Does compensatory plasticity in the motor drive to breathe offer a potential therapeutic target in muscular dystrophy?'. Respiratory Physiology & Neurobiology, [Details] | |
| (2018) | 'Swallow-breathing coordination during incremental ascent to altitude' Alyssa Huff, Trevor A. Day, Mason English, Mitchell D. Reed, Shaelynn Zouboules, Gurkarn Saran, Jack K. Leacy, Carli Mann, Joel D.B. Peltonen, Ken D. O’Halloran, Mingma T. Sherpa, Teresa Pitts (2018) 'Swallow-breathing coordination during incremental ascent to altitude'. Respiratory Physiology & Neurobiology, [Details] | |
| (2018) | 'Extreme Pregnancy: Maternal Physical Activity at Everest Base Camp' Davenport MH, Steinback CD, Borle K, Matenchuk BA, Vanden Berg ER, de Freitas EM, Linares AM, O’Halloran KD, Sherpa MT, Day TA (2018) 'Extreme Pregnancy: Maternal Physical Activity at Everest Base Camp'. Journal of Applied Physiology, [Details] | |
| (2018) | 'Neuroimmune modulation of cardiorespiratory responses to acute severe hypoxia' O'Halloran KD (2018) 'Neuroimmune modulation of cardiorespiratory responses to acute severe hypoxia'. Experimental Physiology, [Details] | |
| (2018) | 'Diaphragm plasticity in aging and disease: therapies for muscle weakness go from strength to strength' Greising SM, Ottenheijm CAC, O'Halloran KD, Barreiro E. (2018) 'Diaphragm plasticity in aging and disease: therapies for muscle weakness go from strength to strength'. Journal of Applied Physiology, [Details] | |
| (2018) | 'Diaphragm muscle weakness following acute sustained hypoxic stress in the mouse is prevented by pre-treatment with N-acetyl cysteine' O'Leary AJ, Drummond SE, Edge D, O'Halloran KD (2018) 'Diaphragm muscle weakness following acute sustained hypoxic stress in the mouse is prevented by pre-treatment with N-acetyl cysteine'. Oxidative Medicine and Cellular Longevity, 2018:4805493 [Details] | |
| (2018) | 'N-acylethanolamine and endocannabinoid levels in burning mouth syndrome: potential role in disease pathogenesis' Barry A, O'Halloran KD, McKenna JP, McCreary C, Harhen B, Kerr DM, Finn DP, Downer EJ (2018) 'N-acylethanolamine and endocannabinoid levels in burning mouth syndrome: potential role in disease pathogenesis'. Journal of Oral Pathology and Medicine, 47 :40-42 [Details] | |
| (2018) | 'Sympathetic vasomotor activity during dynamic exercise with resistive breathing: Sex differences and the nerve to show it!' O'Halloran, Ken D. (2018) 'Sympathetic vasomotor activity during dynamic exercise with resistive breathing: Sex differences and the nerve to show it!'. Experimental Physiology, [DOI] [Full Text] [Details] | |
| (2018) | 'Chronic intermittent hypoxia and renovascular hypertension: A case of one plus one equals one-half!' O'Halloran, Ken D. (2018) 'Chronic intermittent hypoxia and renovascular hypertension: A case of one plus one equals one-half!'. Experimental Physiology, 103 :433-434 [DOI] [Full Text] [Details] | |
| (2018) | 'Impact of short-term cycle ergometer training on quality of life, cognition and depressive symptomatology in multiple sclerosis patients: a pilot study' Barry A, Cronin O, Ryan AM, Sweeney B, O’Toole O, Allen AP, Clarke G, O’Halloran KD, Downer EJ (2018) 'Impact of short-term cycle ergometer training on quality of life, cognition and depressive symptomatology in multiple sclerosis patients: a pilot study'. Neurological Sciences, 39 :461-469 [Details] | |
| (2018) | 'Antioxidant therapy for muscular dystrophy: Caveat lector!' O'Halloran KD, Murphy KH, Burns DP (2018) 'Antioxidant therapy for muscular dystrophy: Caveat lector!'. The Journal of Physiology, 596 :737-738 [Details] | |
| (2018) | 'Pharmacotherapies for apnoea of prematurity: time to pause and consider targeted sex-specific strategies?' O'Halloran KD, McDonald FB (2018) 'Pharmacotherapies for apnoea of prematurity: time to pause and consider targeted sex-specific strategies?'. Experimental Physiology, 103 :170-171 [Details] | |
| (2018) | 'Plasma IL-8 signature correlates with pain and depressive symptomatology in patients with Burning Mouth Syndrome: results from a pilot study' Barry A, O'Halloran KD, McKenna J, McCreary C, Downer EJ (2018) 'Plasma IL-8 signature correlates with pain and depressive symptomatology in patients with Burning Mouth Syndrome: results from a pilot study'. Journal Of Oral Pathology & Medicine, 47 :158-165 [Details] | |
| (2018) | 'Sleep awakens active expiration' O'Halloran KD (2018) 'Sleep awakens active expiration'. The Journal of Physiology, 596 :2947-2948 [Details] | |
| (2017) | 'Tempol supplementation restores diaphragm force and metabolic enzyme activities in mdx mice' Burns DP, Ali I, Rieux C, Healy J, Jasionek G, O'Halloran KD (2017) 'Tempol supplementation restores diaphragm force and metabolic enzyme activities in mdx mice'. Antioxidants (Basel, Switzerland), 6 (4) [Details] | |
| (2017) | 'Sensorimotor control of breathing in the mdx mouse model of Duchenne muscular dystrophy' Burns David P.; Roy Arijit; Lucking Eric F.; McDonald Fiona B.; Gray Sam; Wilson Richard J.; Edge Deirdre; O'Halloran Ken D. (2017) 'Sensorimotor control of breathing in the mdx mouse model of Duchenne muscular dystrophy'. Journal of Physiology, 595 (21):6653-6672 [DOI] [Full Text] [Details] | |
| (2017) | 'Squamous papilloma causing airway obstruction during conscious sedation' Brady P, McCreary C, O'Halloran KD, Gallagher C (2017) 'Squamous papilloma causing airway obstruction during conscious sedation'. Anesthesia progress, 64 (3):168-170 [Details] | |
| (2017) | 'Respiratory muscle dysfunction in animal models of hypoxic disease: Antioxidant therapy goes from strength to strength' O'Halloran KD, Lewis P (2017) 'Respiratory muscle dysfunction in animal models of hypoxic disease: Antioxidant therapy goes from strength to strength'. Hypoxia, 5 :75-84 [Details] | |
| (2017) | 'Resistive breathing and respiratory muscle fatigue: a load of concern just expired!' O'Halloran, Ken D. (2017) 'Resistive breathing and respiratory muscle fatigue: a load of concern just expired!'. Experimental Physiology, 102 (9):1090-1091 [DOI] [Full Text] [Details] | |
| (2017) | 'Restoration of pharyngeal dilator muscle force in dystrophin-deficient (mdx) mice following co-treatment with neutralizing interleukin-6 receptor antibodies and urocortin-2' Burns, David P.; Rowland, Jane; Canavan, Leonie; Murphy, Kevin H.; Brannock, Molly; O'Malley, Dervla; O'Halloran, Ken D.; Edge, Deirdre (2017) 'Restoration of pharyngeal dilator muscle force in dystrophin-deficient (mdx) mice following co-treatment with neutralizing interleukin-6 receptor antibodies and urocortin-2'. Experimental Physiology, 102 (9):1177-1193 [DOI] [Full Text] [Details] | |
| (2017) | 'Microstream capnography during conscious sedation with midazolam for oral surgery: A randomised controlled trial' Brady P, Iohom G, O' Halloran KD, Mc Creary C, Cronin M (2017) 'Microstream capnography during conscious sedation with midazolam for oral surgery: A randomised controlled trial'. British Dental Journal, BDJ Open 3 (17019) [Details] | |
| (2017) | 'What's new in ... Capnography Monitoring for Dental Conscious Sedation: A Clinical Review' Brady P, Hayes M, O'Halloran K, Giovannitti J (2017) 'What's new in ... Capnography Monitoring for Dental Conscious Sedation: A Clinical Review'. SAAD digest, 33 :3-6 [Full Text] [Details] | |
| (2017) | 'High adventure shunts old notions of pulmonary vascular control during hypoxic exercise: contrasting views that might just burst your bubble!' O'Halloran KD (2017) 'High adventure shunts old notions of pulmonary vascular control during hypoxic exercise: contrasting views that might just burst your bubble!'. Experimental Physiology, 102 (6):617-618 [Details] | |
| (2017) | 'Combined xIL-6R and urocortin-2 treatment restores mdx diaphragm muscle force' Manning J, Buckley MM, O'Halloran KD, O'Malley D (2017) 'Combined xIL-6R and urocortin-2 treatment restores mdx diaphragm muscle force'. Muscle & Nerve, :1-7 [DOI] [Full Text] [Details] | |
| (2017) | 'A randomized control trial of end-tidal carbon dioxide monitoring of preterm infants in the delivery room' Hawkes GA, Finn D, Kenosi M, Livingstone V, O'Toole JM, Boylan GB, O'Halloran KD, Ryan AC, Dempsey EM. (2017) 'A randomized control trial of end-tidal carbon dioxide monitoring of preterm infants in the delivery room'. Journal of Pediatrics, 182 :74-78 [DOI] [Details] | |
| (2016) | 'Psg22 null mouse embryos develop normally under normoxic and hypoxic conditions of pregnancy' Williams JM, Bezak T, Das M, Ning Z, Lucking EF, Kelly VP, Harrison P, Young P, O'Connell MJ, Dockery P, O'Halloran KD, Moore T. (2016) 'Psg22 null mouse embryos develop normally under normoxic and hypoxic conditions of pregnancy'. 10.19185/matters.201611000023 [Details] | |
| (2016) | 'Diaphragm muscle adaptation to sustained hypoxia: lessons from animal models with relevance to high altitude and chronic respiratory diseases' Lewis, Philip; O'Halloran Ken D. (2016) 'Diaphragm muscle adaptation to sustained hypoxia: lessons from animal models with relevance to high altitude and chronic respiratory diseases'. Frontiers in Physiology, 7 [DOI] [Full Text] [Details] | |
| (2016) | 'Sex, stress and sleep apnoea: decreased susceptibility to upper airway muscle dysfunction following intermittent hypoxia in females' O’Halloran, Ken D.; Lewis, Philip; McDonald, Fiona (2016) 'Sex, stress and sleep apnoea: decreased susceptibility to upper airway muscle dysfunction following intermittent hypoxia in females'. Respiratory Physiology & Neurobiology, :1-7 [DOI] [Full Text] [Details] | |
| (2016) | 'The health of physiology: a perspective' O'Halloran KD (2016) 'The health of physiology: a perspective'. Physiological Mini Reviews, 9 (6):50-59 [Details] | |
| (2016) | 'Measure what is measurable: IJMS comes of age as the baton changes hands' O'Halloran KD (2016) 'Measure what is measurable: IJMS comes of age as the baton changes hands'. Irish Journal of Medical Science, 185 (4):769-769 [Details] | |
| (2016) | 'Physiology in fine fettle in the fair city' O'Halloran KD (2016) 'Physiology in fine fettle in the fair city'. Irish Journal of Medical Science, 185 (4):771-771 [Details] | |
| (2016) | 'Capnography monitoring during dental conscious sedation' Brady P, Gallagher C, McCarthy C, O'Halloran K, McGreary C, Ioham G. (2016) 'Capnography monitoring during dental conscious sedation'. Oral Surgery, [Details] | |
| (2016) | 'A paradigm shift in oxygen sensing with a twist in the tale!' O'Halloran, Ken D. (2016) 'A paradigm shift in oxygen sensing with a twist in the tale!'. Biochemical Journal, :2687-2689 [DOI] [Full Text] [Details] | |
| (2016) | 'Counter-regulatory control of homeostasis during hypoglycaemia: adrenaline hits the sweet spot in the controversy concerning carotid body glucose sensing' O'Halloran KD (2016) 'Counter-regulatory control of homeostasis during hypoglycaemia: adrenaline hits the sweet spot in the controversy concerning carotid body glucose sensing'. The Journal of Physiology, 594 :4091-4092 [Details] | |
| (2016) | 'Effects of gestational and postnatal exposure to chronic intermittent hypoxia on diaphragm muscle contractile function in the rat' McDonald, Fiona B.; Dempsey, Eugene M.; O'Halloran Ken D. (2016) 'Effects of gestational and postnatal exposure to chronic intermittent hypoxia on diaphragm muscle contractile function in the rat'. Frontiers in Physiology, 7 [DOI] [Full Text] [Details] | |
| (2016) | 'Sex differences in murine sternohyoid muscle tolerance of acute severe hypoxic stress' Lewis P, O'Halloran KD (2016) 'Sex differences in murine sternohyoid muscle tolerance of acute severe hypoxic stress'. Physiological Research, [Details] | |
| (2016) | 'Impact of exercise on innate immunity in multiple sclerosis progression and symptomatology' Barry, Alison; Cronin, Owen; Ryan, Aisling M; Sweeney, Brian; Yap, Siew M.; O'Toole, Orna; Allen, Andrew P.; Clarke, Gerard; O'Halloran, Ken D.; Downer, Eric J. (2016) 'Impact of exercise on innate immunity in multiple sclerosis progression and symptomatology'. Frontiers in Physiology, 7 [DOI] [Full Text] [Details] | |
| (2016) | 'Engineering a solution to explore the cardiorespiratory limits to exercise performance --- take a load off!' O'Halloran KD (2016) 'Engineering a solution to explore the cardiorespiratory limits to exercise performance --- take a load off!'. Experimental Physiology, 101 :695-696 [Details] | |
| (2016) | 'Early life exposure to chronic intermittent hypoxia primes increased susceptibility to hypoxia-induced weakness in rat sternohyoid muscle during adulthood' McDonald Fiona B.; Dempsey Eugene M.; O'Halloran Ken D. (2016) 'Early life exposure to chronic intermittent hypoxia primes increased susceptibility to hypoxia-induced weakness in rat sternohyoid muscle during adulthood'. Frontiers in Physiology, 7 [DOI] [Full Text] [Details] | |
| (2016) | 'In vivo neutralisation of IL-6 receptors ameliorates gastrointestinal dysfunction in dystrophin-deficient mdx mice' Manning J, Buckley MM, O'Halloran KD, O'Malley D (2016) 'In vivo neutralisation of IL-6 receptors ameliorates gastrointestinal dysfunction in dystrophin-deficient mdx mice'. Neurogastroenterology and Motility, 28 (7):1016-1026 [Details] | |
| (2016) | 'Tetany during intravenous conscious sedation in dentistry resulting from hyperventilation-induced hypocapnia' McCarthy C, Brady P, O'Halloran KD, McCreary C (2016) 'Tetany during intravenous conscious sedation in dentistry resulting from hyperventilation-induced hypocapnia'. Anesthesia progress, 63 :25-30 [Details] | |
| (2016) | 'Blast from the past! Phrenic motor memory of antecedent episodic hypercapnia is serotonin dependent: Relevance to respiratory rehabilitation and sleep-disordered breathing?' O'Halloran KD (2016) 'Blast from the past! Phrenic motor memory of antecedent episodic hypercapnia is serotonin dependent: Relevance to respiratory rehabilitation and sleep-disordered breathing?'. Experimental Physiology, 101 (2):258-259 [Details] | |
| (2016) | 'Evidence of hypoxic tolerance in weak upper airway muscle from young mdx mice' Burns DP, O'Halloran KD (2016) 'Evidence of hypoxic tolerance in weak upper airway muscle from young mdx mice'. Respiratory Physiology & Neurobiology, 226 :68-75 [Details] | |
| (2016) | 'Redox remodeling is pivotal in murine diaphragm muscle adaptation to chronic sustained hypoxia' Lewis P, Sheehan D, Soares R, Varela Coelho A, O'Halloran KD (2016) 'Redox remodeling is pivotal in murine diaphragm muscle adaptation to chronic sustained hypoxia'. American Journal of Respiratory Cell and Molecular Biology, 55 :12-23 [Details] | |
| (2016) | 'Diaphragm muscle weakness and increased UCP-3 gene expression following acute hypoxic stress in the mouse' O'Leary AJ, O'Halloran KD (2016) 'Diaphragm muscle weakness and increased UCP-3 gene expression following acute hypoxic stress in the mouse'. Respiratory Physiology & Neurobiology, 226 :76-80 [Details] | |
| (2016) | 'Chronic intermittent hypoxia creates the perfect storm with calamitous consequences for respiratory control' O'Halloran KD (2016) 'Chronic intermittent hypoxia creates the perfect storm with calamitous consequences for respiratory control'. Respiratory Physiology & Neurobiology, 226 :63-67 [Details] | |
| (2016) | 'Delivery room end tidal CO2 monitoring in preterm infants less than 32 weeks' Hawkes GA, Kenosi M, Finn D, O'Toole JM, O'Halloran KD, Boylan GB, Ryan AC, Dempsey EM (2016) 'Delivery room end tidal CO2 monitoring in preterm infants less than 32 weeks'. Archives Of Disease In Childhood-Fetal And Neonatal Editionarchives Of Disease In Childhood-Fetal And Neonatal Edition, 101 (1):F62-F65 [Details] | |
| (2015) | 'Playing your heart out' O'Halloran KD (2015) 'Playing your heart out'. Irish Journal of Medical Science, 184 :725-726 [Details] | |
| (2015) | 'Effects of fractional inspired oxygen on cerebral oxygenation in preterm infants following delivery' Kenosi M, O'Toole JM, Livingstone V, Hawkes GA, Boylan GB, O'Halloran KD, Ryan AC, Dempsey EM (2015) 'Effects of fractional inspired oxygen on cerebral oxygenation in preterm infants following delivery'. Journal of Pediatrics, 167 (5):1007-1012 [Details] | |
| (2015) | 'Chronic intermittent hypoxia blunts the expression of ventilatory long term facilitation in sleeping rats' Edge D, O'Halloran KD (2015) 'Chronic intermittent hypoxia blunts the expression of ventilatory long term facilitation in sleeping rats'. Advances In Experimental Medicine and Biology, 860 :35-42 [Details] | |
| (2015) | 'Respiratory control in the mdx mouse model of Duchenne muscular dystrophy' Burns DP, Edge D, O'Malley D, O'Halloran KD (2015) 'Respiratory control in the mdx mouse model of Duchenne muscular dystrophy'. Advances In Experimental Medicine and Biology, 860 :239-244 [Details] | |
| (2015) | 'Piling on the pressure to combat acute respiratory distress syndrome: A PEEP into the future?' O'Halloran KD (2015) 'Piling on the pressure to combat acute respiratory distress syndrome: A PEEP into the future?'. Experimental Physiology, [Details] | |
| (2015) | 'Prenatal stress-induced alterations in major physiological systems correlate with gut microbiota composition in adulthood' Golubeva AV, Crampton S, Desbonnet L, Edge D, O’Sullivan O, Lomasney KW, Zhdanov AV, Crispie F, Moloney RD, Borre YE, Cotter PD, Hyland NP, O'Halloran KD,Dinan TG, O'Keeffe GW, Cryan JF (2015) 'Prenatal stress-induced alterations in major physiological systems correlate with gut microbiota composition in adulthood'. Psychoneuroendocrinology, 60 :58-74 [Details] | |
| (2015) | 'Commentaries on Viewpoint: Precedence and autocracy in breathing control' O'Halloran KD (2015) 'Commentaries on Viewpoint: Precedence and autocracy in breathing control'. Journal of Applied Physiology, 118 :1557-1559 [Details] | |
| (2015) | 'Early life exposure to chronic intermittent hypoxia causes upper airway dilator muscle weakness which persists into young adulthood' McDonald FB, Williams R, Sheehan D, O'Halloran KD (2015) 'Early life exposure to chronic intermittent hypoxia causes upper airway dilator muscle weakness which persists into young adulthood'. Experimental Physiology, 100 (8):947-966 [Details] | |
| (2015) | 'Improved tolerance of acute severe hypoxic stress in chronic hypoxic diaphragm is nitric oxide dependent' Lewis P, McMorrow C, Bradford A, O'Halloran KD (2015) 'Improved tolerance of acute severe hypoxic stress in chronic hypoxic diaphragm is nitric oxide dependent'. Journal of Physiological Sciences, 65 (5):843-851 [Details] | |
| (2015) | 'Chronic sustained hypoxia-induced redox remodeling causes contractile dysfunction in mouse sternohyoid muscle' Lewis, Philip; Sheehan, David; Soares, Renata; Coelho, Ana Varela; O'Halloran, Ken D. (2015) 'Chronic sustained hypoxia-induced redox remodeling causes contractile dysfunction in mouse sternohyoid muscle'. Frontiers in Physiology, 6 (122) [DOI] [Full Text] [Details] | |
| (2015) | 'Chronic intermittent hypoxia orchestrates cardiorespiratory cacophony - adapting melody to malady' O'Halloran KD (2015) 'Chronic intermittent hypoxia orchestrates cardiorespiratory cacophony - adapting melody to malady'. Experimental Physiology, 100 :227-228 (Editorial) [Details] | |
| (2015) | 'Chronic intermittent hypoxia increases rat sternohyoid muscle NADPH oxidase expression with attendant modest oxidative stress' Williams, Robert; Lemaire, Paul; Lewis, Philip; McDonald, Fiona B.; Lucking, Eric; Hogan, Sean; Sheehan, David; Healy, Vincent; O'Halloran Ken D. (2015) 'Chronic intermittent hypoxia increases rat sternohyoid muscle NADPH oxidase expression with attendant modest oxidative stress'. Frontiers in Physiology, 6 [DOI] [Full Text] [Details] | |
| (2014) | 'Getting jittery about the mechanism of hypertension in sleep apnoea' O'Halloran KD (2014) 'Getting jittery about the mechanism of hypertension in sleep apnoea'. Experimental Physiology, 99 :1283-1284 (Editorial) [Details] | |
| (2014) | 'Modulation of enteric neurons by Interleukin‐6 and CRF contributes to visceral hypersensitivity and altered colonic motility in a rat model of Irritable Bowel Syndrome' Buckley MM, O'Halloran KD, Rae MG, Dinan TG, and O'Malley D (2014) 'Modulation of enteric neurons by Interleukin‐6 and CRF contributes to visceral hypersensitivity and altered colonic motility in a rat model of Irritable Bowel Syndrome'. Journal of Physiology, 592 :5235-5250 [Details] | |
| (2014) | 'Increased cardiac output contributes to the development of chronic intermittent hypoxia induced hypertension' Lucking EF, O'Halloran KD, Jones JF (2014) 'Increased cardiac output contributes to the development of chronic intermittent hypoxia induced hypertension'. Experimental Physiology, 99 :1312-1324 [Details] | |
| (2014) | 'Effect of chronic intermittent hypoxia on the reflex recruitment of the genioglossus during airway obstruction in the anaesthetized rat' Edge D, McDonald FB, Jones JFX, Bradford A, O'Halloran KD (2014) 'Effect of chronic intermittent hypoxia on the reflex recruitment of the genioglossus during airway obstruction in the anaesthetized rat'. Progress In Brain Research, 209 :147-168 [Details] | |
| (2014) | 'Chronic nitric oxide synthase inhibition does not impair upper airway muscle adaptation to chronic intermittent hypoxia in the rat' McDonald FB, Edge D, O'Halloran KD (2014) 'Chronic nitric oxide synthase inhibition does not impair upper airway muscle adaptation to chronic intermittent hypoxia in the rat'. Progress In Brain Research, 212 :237-251 [Details] | |
| (2014) | 'Effects of prolyl-hydroxylase inhibition and chronic intermittent hypoxia on synaptic transmission and plasticity in the rat CA1 and dentate gyrus' Wall A, Corcoran AE, O'Halloran KD, O'Connor JJ (2014) 'Effects of prolyl-hydroxylase inhibition and chronic intermittent hypoxia on synaptic transmission and plasticity in the rat CA1 and dentate gyrus'. Neurobiology of Disease, 62C :8-17 [Details] | |
| (2014) | 'Sweet success should set tongues wagging: A portrait of airway muscle injury in sleep apnea' O'Halloran KD (2014) 'Sweet success should set tongues wagging: A portrait of airway muscle injury in sleep apnea'. American Journal of Respiratory and Critical Care Medicine, (189):1299-1300 (Editorial) [Details] | |
| (2014) | 'Reactive oxygen species mediated diaphragm fatigue in a rat model of chronic intermittent hypoxia' Shortt CM, Fredsted F, Chow HB, Williams R, Skelly JR, Edge D, Bradford A, O'Halloran KD (2014) 'Reactive oxygen species mediated diaphragm fatigue in a rat model of chronic intermittent hypoxia'. Experimental Physiology, 99 :688-700 [Details] | |
| (2015) | 'The β2 adrenoceptor agonist terbutaline recovers pharyngeal dilator muscle force decline during severe hypoxia' McDonald FB, Skelly JR, O'Halloran KD (2015) 'The β2 adrenoceptor agonist terbutaline recovers pharyngeal dilator muscle force decline during severe hypoxia'. Oral Diseases, 21 (1):e121-e127 [Details] | |
| (2014) | 'Effects of sustained hypoxia on sternohyoid and diaphragm muscle during development' Carberry J, McMorrow C, Bradford A, Jones JFX, O'Halloran KD (2014) 'Effects of sustained hypoxia on sternohyoid and diaphragm muscle during development'. The European Respiratory Journal, 43 :1149-1158 [Details] | |
| (2013) | 'Obstructive sleep apnoea, intermittent hypoxia, and respiratory muscle structure and function' Bradford A and O'Halloran KD (2013) 'Obstructive sleep apnoea, intermittent hypoxia, and respiratory muscle structure and function'. Anatomy & Physiology: Current Research, 3 [DOI] [Details] | |
| (2013) | 'Diaphragm Muscle Remodelling in a Rat Model of Chronic Intermittent Hypoxia' Shortt CM, Fredsted A, Bradford A, O'Halloran KD (2013) 'Diaphragm Muscle Remodelling in a Rat Model of Chronic Intermittent Hypoxia'. Journal of Histochemistry & Cytochemistry, 61 :487-499 [Details] | |
| (2013) | 'Sternohyoid and diaphragm muscle form and function during postnatal development in the rat' O'Connell RA, Carberry J, O'Halloran KD (2013) 'Sternohyoid and diaphragm muscle form and function during postnatal development in the rat'. Experimental Physiology, 98 (9):1386-1400 [Details] | |
| (2013) | 'Hydrogen peroxide alters sternohyoid muscle function' Shortt CM, O'Halloran KD (2013) 'Hydrogen peroxide alters sternohyoid muscle function'. Oral Diseases, 61 :487-499 [DOI] [Details] | |
| (2013) | 'Upper airway dilator muscle weakness following intermittent and sustained hypoxia in the rat: effects of a superoxide scavenger' Skelly JR, Rowan SC, Jones JFX, O'Halloran KD (2013) 'Upper airway dilator muscle weakness following intermittent and sustained hypoxia in the rat: effects of a superoxide scavenger'. Physiological Research, 62 :187-196 [Details] | |
| (2012) | 'Chronic hypobaric hypoxia increases isolated rat fast-twitch and slow-twitch limb muscle force and fatigue' El-Khoury R, Bradford A, O'Halloran KD (2012) 'Chronic hypobaric hypoxia increases isolated rat fast-twitch and slow-twitch limb muscle force and fatigue'. Physiological Research, 61 :195-201 [Details] | |
| (2012) | 'Tempol ameliorates pharyngeal dilator muscle dysfunction in a rodent model of chronic intermittent hypoxia' Skelly JR, Edge D, Shortt CM, Jones JFX, Bradford A, O'Halloran KD. (2012) 'Tempol ameliorates pharyngeal dilator muscle dysfunction in a rodent model of chronic intermittent hypoxia'. American Journal of Respiratory Cell and Molecular Biology, 46 :139-148 [Details] | |
| (2012) | 'Respiratory control and sternohyoid muscle structure and function in aged male rats: Decreased susceptibility to chronic intermittent hypoxia' Skelly JR, Edge D, Shortt CM, Jones JFX, Bradford A, O'Halloran KD. (2012) 'Respiratory control and sternohyoid muscle structure and function in aged male rats: Decreased susceptibility to chronic intermittent hypoxia'. Respiratory Physiology & Neurobiology, 180 (2-3):175-182 [Details] | |
| (2012) | 'Chronic intermittent hypoxia increases apnoea index in sleeping rats' Edge D, Bradford A, O'Halloran KD (2012) 'Chronic intermittent hypoxia increases apnoea index in sleeping rats'. Advances In Experimental Medicine and Biology, 758 :359-363 [Details] | |
| (2012) | 'Propranolol does not affect the hindlimb vasodilatation elicited by stimulation of superior laryngeal nerve paraganglia' O'Connor ET, O'Halloran KD, Jones JFX (2012) 'Propranolol does not affect the hindlimb vasodilatation elicited by stimulation of superior laryngeal nerve paraganglia'. Advances In Experimental Medicine and Biology, 758 :273-277 [Details] | |
| (2012) | 'Pro-inflammatory cytokines do not affect basal or hypoxia stimulated discharge of rat vagal paraganglia' O'Connor ET, O'Halloran KD, Jones JFX (2012) 'Pro-inflammatory cytokines do not affect basal or hypoxia stimulated discharge of rat vagal paraganglia'. Experimental Physiology, 97 :1203-1210 [Details] | |
| (2012) | 'Comparison of the motor discharge to the voluntary sphincters of continence in the rat' Buffini M, O'Halloran KD, O'Herlihy C, O'Connell PR, Jones JFX (2012) 'Comparison of the motor discharge to the voluntary sphincters of continence in the rat'. Neurogastroenterology and Motility, 24 :e175-184 [Details] | |
| (2012) | 'Chronic intermittent hypoxia alters genioglossus motor unit discharge patterns in the anaesthetized rat' Edge D, Bradford A, Jones JFX, O'Halloran KD (2012) 'Chronic intermittent hypoxia alters genioglossus motor unit discharge patterns in the anaesthetized rat'. Advances In Experimental Medicine and Biology, 758 :295-300 [Details] | |
| (2011) | 'Structural and functional properties of an upper airway dilator muscle in aged obese male rats' Skelly JR, O'Connell RA, Jones JFX, O'Halloran KD. (2011) 'Structural and functional properties of an upper airway dilator muscle in aged obese male rats'. Respiration, 82 :539-549 [Details] | |
| (2011) | 'Chronic hypoxia increases rat diaphragm muscle endurance and sodium-potassium ATPase pump content' McMorrow C, Fredsted A, O'Connell RA, Carberry J, Bradford A, Jones JFX, O'Halloran KD. (2011) 'Chronic hypoxia increases rat diaphragm muscle endurance and sodium-potassium ATPase pump content'. European Respiratory Journal: the offical journal of the European Respiratory Society, 37 :1474-1481 [Details] | |
| (2011) | 'Double-trouble for respiratory control in Pompe disease' O'Halloran, Ken D. (2011) 'Double-trouble for respiratory control in Pompe disease'. Frontiers in Physiology, 2 [DOI] [Full Text] [Details] | |
| (2010) | 'Superoxide scavengers improve rat pharyngeal dilator muscle performance' Skelly JR, Bradford A, Jones JFX, O'Halloran KD. (2010) 'Superoxide scavengers improve rat pharyngeal dilator muscle performance'. American Journal of Respiratory Cell and Molecular Biology, 42 :725-731 [Details] | |
| (2010) | 'Antioxidant treatment does not prevent hypoxia-induced impairment of respiratory muscle function in developing rats' Carberry J, Bradford A, O'Halloran KD (2010) 'Antioxidant treatment does not prevent hypoxia-induced impairment of respiratory muscle function in developing rats'. Advances in Experimental Medicine and Biology, 669 :263-266 [Details] | |
| (2010) | 'Comparison of the contractile properties, oxidative capacities and fibre type profiles of the voluntary sphincters of continence in the rat' Buffini M, O'Halloran KD, O'Herlihy C, O'Connell R, Jones JF. (2010) 'Comparison of the contractile properties, oxidative capacities and fibre type profiles of the voluntary sphincters of continence in the rat'. Journal of Anatomy, 217 :187-195 [Details] | |
| (2010) | 'Effects of pro-inflammatory cytokines on the discharge rate of vagal nerve paraganglia in the rat' MacGrory B, O'Connor ET, O'Halloran KD, Jones JFX. (2010) 'Effects of pro-inflammatory cytokines on the discharge rate of vagal nerve paraganglia in the rat'. Respiratory Physiology & Neurobiology, 171 :122-127 [Details] | |
| (2010) | 'Intermittent hypoxia impairs pharyngeal dilator muscle function in male but not female rats' Skelly JR, Bradford A, O'Halloran KD. (2010) 'Intermittent hypoxia impairs pharyngeal dilator muscle function in male but not female rats'. Advances In Experimental Medicine and Biology, 669 :285-287 [Details] | |
| (2010) | 'Respiratory plasticity in the behaving rat following chronic intermittent hypoxia' Edge D, Skelly JR, Bradford A, O'Halloran KD (2010) 'Respiratory plasticity in the behaving rat following chronic intermittent hypoxia'. Advances in Experimental Medicine and Biology, 669 :267-270 [Details] | |
| (2009) | ''Ventilatory drive is enhanced in male and female rats following chronic intermittent hypoxia' Edge D, Skelly JR, Bradford A, O'Halloran KD (2009) ''Ventilatory drive is enhanced in male and female rats following chronic intermittent hypoxia'. Advances in Experimental Medicine and Biology, 648 :337-344 [Details] | |
| (2008) | 'Upper airway pressure-flow relationships and pharyngeal constrictor EMG activity during prolonged expiration in awake goats' O'Halloran KD, Bisgard GE. (2008) 'Upper airway pressure-flow relationships and pharyngeal constrictor EMG activity during prolonged expiration in awake goats'. Journal of Applied Physiology, 105 :100-108 [Details] | |
| (2008) | 'Oxidative stress impairs upper airway muscle endurance in an animal model of sleep-disordered breathing' Dunleavy M, Bradford A, O'Halloran KD. (2008) 'Oxidative stress impairs upper airway muscle endurance in an animal model of sleep-disordered breathing'. Advances in Experimental Medicine and Biology, 605 :458-462 [Details] | |
| (2007) | 'Respiratory plasticity after changes in oxygen supply and demand' Bavis RW, Powell FL, Bradford A, Hsia CCW, Peltonen JE, Soliz J, Zeis B, Fergusson EK, Fu Z, Gassmann M, Kim CB, Maurer J, Miller BM, O'Halloran KD, Paul RJ, Reid SG, Rusko HK, Tikkanen HO, Wilkinson KA. (2007) 'Respiratory plasticity after changes in oxygen supply and demand'. Integrative and Comparative Biology, 47 :532-551 [Details] | |
| (2007) | 'The pathophysiology of sleep apnoea: what we have learned from animal models of chronic intermittent hypoxia' O'Halloran KD, Bradford A. (2007) 'The pathophysiology of sleep apnoea: what we have learned from animal models of chronic intermittent hypoxia'. Current Respiratory Medicine Reviews, 3 :19-27 [Details] | |
| (2007) | 'The effects of breath-holds and Muller manoeuvres on upper airway carbon dioxide concentration in humans' Raza A, Farrell T, O'Halloran KD, Bradford A. (2007) 'The effects of breath-holds and Muller manoeuvres on upper airway carbon dioxide concentration in humans'. Respiration, 74 :533-536 [Details] | |
| (2006) | 'Effects of nicotine on rat sternohyoid muscle contractile properties' O'Halloran KD. (2006) 'Effects of nicotine on rat sternohyoid muscle contractile properties'. Respiratory Physiology & Neurobiology, 150 :200-210 [Details] | |
| (2005) | 'Does episodic hypoxia affect upper airway dilator muscle function? Implications for the pathophysiology of obstructive sleep apnoea' Bradford A, McGuire M, O'Halloran KD. (2005) 'Does episodic hypoxia affect upper airway dilator muscle function? Implications for the pathophysiology of obstructive sleep apnoea'. Respiratory Physiology & Neurobiology, 147 :223-234 [Details] | |
| (2003) | 'Dopaminergic excitation of the goat carotid body is mediated by the serotonin type 3 receptor subtype' Herman JK, O'Halloran KD, Janssen PL, Bisgard GE. (2003) 'Dopaminergic excitation of the goat carotid body is mediated by the serotonin type 3 receptor subtype'. Respiratory Physiology & Neurobiology, 136 :1-12 [Details] | |
| (2003) | 'Upper airway EMG responses to acute hypoxia and asphyxia are impaired in streptozotocin-induced diabetic rats' O'Halloran KD, McGuire M, O'Hare T, MacDermott M, Bradford A. (2003) 'Upper airway EMG responses to acute hypoxia and asphyxia are impaired in streptozotocin-induced diabetic rats'. Respiratory Physiology & Neurobiology, 138 :301-308 [Details] | |
| (2003) | 'Effects of chronic hypobaric hypoxia on contractile properties of rat sternohyoid and diaphragm muscles' El-Khoury R, O'Halloran KD, Bradford A. (2003) 'Effects of chronic hypobaric hypoxia on contractile properties of rat sternohyoid and diaphragm muscles'. Clinical and Experimental Pharmacology and Physiology, 30 :551-554 [Details] | |
| (2002) | 'Chronic intermittent asphyxia impairs rat upper airway muscle responses to acute hypoxia and asphyxia' O'Halloran KD, McGuire M, O'Hare T, Bradford A. (2002) 'Chronic intermittent asphyxia impairs rat upper airway muscle responses to acute hypoxia and asphyxia'. Chest, 122 :269-275 [Details] | |
| (2001) | 'Effect of 8-OH DPAT and ketanserin on the ventilatory acclimatization to hypoxia in awake goats' Herman JK, O'Halloran KD, Bisgard GE. (2001) 'Effect of 8-OH DPAT and ketanserin on the ventilatory acclimatization to hypoxia in awake goats'. Respiratory Physiology & Neurobiology, 124 :95-104 [Details] | |
| (2001) | 'Activation of medullary post-inspiratory related neurons during clonidine-induced central apnea in anesthetized goats' O'Halloran KD, Herman JK, Bisgard GE. (2001) 'Activation of medullary post-inspiratory related neurons during clonidine-induced central apnea in anesthetized goats'. Advances in Experimental Medicine and Biology, 499 :75-79 [Details] | |
| (2001) | 'Pharmacological and immunochemical evidence for dopamine D3 receptors in the goat carotid body' Wang Z-Y, Herman JK, O'Halloran KD, Keith IM, Bisgard GE. (2001) 'Pharmacological and immunochemical evidence for dopamine D3 receptors in the goat carotid body'. Advances in Experimental Medicine and Biology, 499 :49-53 [Details] | |
| (2001) | 'Ventilatory effects of alpha2-adrenoceptor blockade in awake goats' O'Halloran KD, Herman JK, Bisgard GE. (2001) 'Ventilatory effects of alpha2-adrenoceptor blockade in awake goats'. Respiratory Physiology & Neurobiology, 126 :29-41 [Details] | |
| (2001) | 'Alpha2A-adrenoceptor mediated tachypnea in awake goats' O'Halloran KD, Herman JK, Bisgard GE. (2001) 'Alpha2A-adrenoceptor mediated tachypnea in awake goats'. Respiratory Physiology & Neurobiology, 125 :169-179 [Details] | |
| (2001) | 'Sustained moderate hyperoxia augments the acute hypoxic response in awake goats' Herman JK, O'Halloran KD, Bisgard GE. (2001) 'Sustained moderate hyperoxia augments the acute hypoxic response in awake goats'. Advances in Experimental Medicine and Biology, 499 :325-330 [Details] | |
| (2000) | 'Clonidine induces upper airway closure in awake goats' O'Halloran KD, Herman JK, Bisgard GE. (2000) 'Clonidine induces upper airway closure in awake goats'. Respiratory Physiology & Neurobiology, 123 :165-176 [Details] | |
| (2000) | 'Serotonin and the hypoxic ventilatory response in awake goats' Herman JK, O'Halloran KD, Bisgard GE. (2000) 'Serotonin and the hypoxic ventilatory response in awake goats'. Advances in Experimental Medicine and Biology, 475 :559-569 [Details] | |
| (2000) | 'Effects of upper airway carbon dioxide on upper airway resistance and muscle activity in young guinea-pigs' Curran AK, O'Halloran KD, Bradford A. (2000) 'Effects of upper airway carbon dioxide on upper airway resistance and muscle activity in young guinea-pigs'. European Respiratory Journal: the offical journal of the European Respiratory Society, 15 :902-905 [Details] | |
| (2000) | 'Dopaminergic excitation in goat carotid body may be mediated by serotonin receptors' O'Halloran KD, Herman JK, Janssen PL, Bisgard GE. (2000) 'Dopaminergic excitation in goat carotid body may be mediated by serotonin receptors'. Advances in Experimental Medicine and Biology, 475 :581-588 [Details] | |
| (1999) | 'Respiratory-related pharyngeal constrictor muscle activity in awake goats' O'Halloran KD, Herman JK, Bisgard GE. (1999) 'Respiratory-related pharyngeal constrictor muscle activity in awake goats'. Respiratory Physiology & Neurobiology, 116 :9-23 [Details] | |
| (1999) | 'Methysergide augments the acute, but not the sustained, hypoxic ventilatory response in goats' Herman JK, O'Halloran KD, Bisgard GE. (1999) 'Methysergide augments the acute, but not the sustained, hypoxic ventilatory response in goats'. Respiratory Physiology & Neurobiology, 118 :25-37 [Details] | |
| (1999) | 'Nonvagal tachypnea following alpha2-adrenoceptor stimulation in awake goats' O'Halloran KD, Herman JK, Bisgard GE (1999) 'Nonvagal tachypnea following alpha2-adrenoceptor stimulation in awake goats'. Respiratory Physiology & Neurobiology, 118 :15-24 [Details] | |
| (1999) | 'Differential effects of clonidine on upper airway abductor and adductor muscle activity in awake goats' O'Halloran KD, Herman JK, Bisgard GE. (1999) 'Differential effects of clonidine on upper airway abductor and adductor muscle activity in awake goats'. Journal of Applied Physiology, 87 :590-597 [Details] | |
| (1998) | 'Inhibitory dopaminergic mechanisms are functional in peripherally chemodenervated goats' O'Halloran KD, Janssen PL, Bisgard GE. (1998) 'Inhibitory dopaminergic mechanisms are functional in peripherally chemodenervated goats'. Advances in Experimental Medicine and Biology, 450 :7-15 [Details] | |
| (1998) | 'Carotid body dopaminergic mechanisms are functional after acclimatization to hypoxia in goats' Janssen PL, O'Halloran KD, Pizarro J, Dwinell MR, Bisgard GE. (1998) 'Carotid body dopaminergic mechanisms are functional after acclimatization to hypoxia in goats'. Respiratory Physiology & Neurobiology, 111 :25-32 [Details] | |
| (1998) | 'Dopaminergic modulation of respiratory motor output in peripherally chemodenervated goats' O'Halloran KD, Janssen PL, Bisgard GE. (1998) 'Dopaminergic modulation of respiratory motor output in peripherally chemodenervated goats'. Journal of Applied Physiology, 85 :946-954 [Details] | |
| (1998) | 'Upper airway cooling reduces upper airway resistance in anaesthetized young guinea-pigs' Curran AK, O'Halloran KD, Bradford A. (1998) 'Upper airway cooling reduces upper airway resistance in anaesthetized young guinea-pigs'. European Respiratory Journal: the offical journal of the European Respiratory Society, 11 :1257-1262 [Details] | |
| (1998) | 'Influence of cervical sympathetic nerves on ventilation and upper airway resistance in the rat' O'Halloran KD, Curran AK, Bradford A. (1998) 'Influence of cervical sympathetic nerves on ventilation and upper airway resistance in the rat'. European Respiratory Journal: the offical journal of the European Respiratory Society, 12 :177-184 [Details] | |
| (1997) | 'Effects of partial nerve injury on the responses of C-fiber polymodal nociceptors to adrenergic agonists' O'Halloran KD, Perl ER. (1997) 'Effects of partial nerve injury on the responses of C-fiber polymodal nociceptors to adrenergic agonists'. Brain Research, 759 :233-240 [Details] | |
| (1996) | 'Ventilatory and upper airway muscle responses to upper airway CO2 in anaesthetized neonatal guinea-pigs' Curran AK, O'Halloran KD, Bradford A. (1996) 'Ventilatory and upper airway muscle responses to upper airway CO2 in anaesthetized neonatal guinea-pigs'. Advances in Experimental Medicine and Biology, 410 :449-453 [Details] | |
| (1996) | 'Effect of upper airway cooling and CO2 on diaphragm and geniohyoid muscle activity in the rat' O'Halloran KD, Curran AK, Bradford A (1996) 'Effect of upper airway cooling and CO2 on diaphragm and geniohyoid muscle activity in the rat'. The European Respiratory Journal, 9 :2323-2327 [Details] | |
| (1996) | 'The effect of sympathetic nerve stimulation on ventilation and upper airway resistance in the anaesthetized rat' O'Halloran KD, Curran AK, Bradford A. (1996) 'The effect of sympathetic nerve stimulation on ventilation and upper airway resistance in the anaesthetized rat'. Advances in Experimental Medicine and Biology, 410 :443-447 [Details] | |
| (1996) | 'Effect of almitrine on ventilation and on diaphragm and geniohyoid muscle activity in the rat' O'Halloran KD, Curran AK, Bradford A. (1996) 'Effect of almitrine on ventilation and on diaphragm and geniohyoid muscle activity in the rat'. Clinical Science, 91 :337-345 [Details] | |
| (1995) | 'Effects of superior laryngeal nerve section on ventilation in neonatal guinea-pigs' Curran AK, O'Halloran KD, Bradford A. (1995) 'Effects of superior laryngeal nerve section on ventilation in neonatal guinea-pigs'. Respiratory Physiology & Neurobiology, 101 :23-29 [Details] | |
| (1994) | 'The effects of laryngeal CO2 and cooling on ventilation and laryngeal resistance in the anaesthetized rat' O'Halloran KD, Curran AK, Bradford A. (1994) 'The effects of laryngeal CO2 and cooling on ventilation and laryngeal resistance in the anaesthetized rat'. Advances in Experimental Medicine and Biology, 360 :389-391 [Details] | |
| (1994) | 'The effects of airway CO2 and cooling on ventilation and upper airway resistance in anaesthetized rats' Curran AK, O'Halloran KD, Bradford A. (1994) 'The effects of airway CO2 and cooling on ventilation and upper airway resistance in anaesthetized rats'. Advances in Experimental Medicine and Biology, 360 :393-395 [Details] | |
| (1994) | 'Ventilatory and upper airway resistance responses to upper-airway cooling and CO2 in anaesthetised rats' O'Halloran KD, Curran AK, Bradford A. (1994) 'Ventilatory and upper airway resistance responses to upper-airway cooling and CO2 in anaesthetised rats'. Pflugers Archives : European journal of physiology, 429 :262-266 [Details] |
Book Chapters
| Year | Publication | |
|---|---|---|
| (2009) | 'Effects of intermittent hypoxia on pulmonary arterial pressure and right ventricular mass' Bradford A, O'Halloran KD. (2009) 'Effects of intermittent hypoxia on pulmonary arterial pressure and right ventricular mass' In: Intermittent hypoxia: From molecular mechanisms to clinical applications. New York: Nova Science. [Details] | |
| (2009) | 'Upper airway dysfunction following chronic intermittent hypoxia - implications for the pathophysiology of sleep-disordered breathing' O'Halloran KD (2009) 'Upper airway dysfunction following chronic intermittent hypoxia - implications for the pathophysiology of sleep-disordered breathing' In: Intermittent hypoxia: From molecular mechanisms to clinical applications. New York: Nova Science. [Details] | |
| (2007) | 'Tempol increases rat upper airway muscle force' Skelly JR, Bradford A, O'Halloran KD. (2007) 'Tempol increases rat upper airway muscle force' In: Proceedings of the Joint Meeting of the Slovak Physiological Society, the Physiological Society and the Federation of European Physiological Sciences. Italy: Medimond S.r.l. [Details] | |
| (2007) | 'Respiratory plasticity following chronic intermittent hypercapnic hypoxia in conscious rats' O'Halloran KD, McGuire M, Bradford A. (2007) 'Respiratory plasticity following chronic intermittent hypercapnic hypoxia in conscious rats' In: Proceedings of the Joint Meeting of the Slovak Physiological Society, the Physiological Society and the Federation of European Physiological Sciences. Italy: Medimond S.r.l. [Details] | |
| (2007) | 'Effects of chronic hypobaric hypoxia on rat diaphragm muscle contractile properties' McMorrow C, Bradford A, O'Halloran KD. (2007) 'Effects of chronic hypobaric hypoxia on rat diaphragm muscle contractile properties' In: Proceedings of the Joint Meeting of the Slovak Physiological Society, the Physiological Society and the Federation of European Physiological Sciences. Italy: Medimond S.r.l. [Details] | |
| (2005) | 'Intermittent airway occlusion increases serum [K+] and the incidence of cardiac arrhythmias in anaesthetized rats' Dunleavy M, Lane D, O'Halloran KD, Bradford A. (2005) 'Intermittent airway occlusion increases serum [K+] and the incidence of cardiac arrhythmias in anaesthetized rats' In: Proceedings of the 2nd Interim Congress of the World Federation of Sleep Research and Sleep Medicine Societies. Bologna, Italy: Medimond S.r.l. [Details] |
Professional Activities
Honours and Awards
| Year | Title | Awarding Body | |
|---|---|---|---|
| 1992 | Donegan Medal | Royal Academy of Medicine in Ireland | |
| 2000 | Fellow | Royal Academy of Medicine in Ireland | |
| 2001 | President's Prize (Research) | University College Dublin | |
| 2007 | Teaching Award | University College Dublin | |
| 2017 | FPhysiol | The Physiological Society |
Professional Associations
| Association | Function | From / To | |
|---|---|---|---|
| Royal Academy of Medicine in Ireland | Fellow; General Secretary; Member of the Executive Committee | / | |
| Physiological Society | Member; Trustee & Council member | / | |
| Physiological Society | Meetings Secretary (Chair of Meetings Committee) | / | |
| American Physiological Society | Member | / | |
| International Society for Arterial Chemoreception | Member | / |
Committees
| Committee | Function | From / To | |
|---|---|---|---|
| Council (Physiological Society) | Member (Trustee) | / | |
| Executive Committee (Physiological Society) | Member | / | |
| Meetings Committee (Physiological Society) | Chair | / | |
| Publications Committee (Physiological Society) | Member | / | |
| Executive Committee (Royal Academy of Medicine) | Member (General Secretary of the Academy) | / | |
| Editorial Board of Experimental Physiology | Member | / | |
| Executive Editor (Irish J Med Sci) | Member (Editorial Board) | / | |
| Biomedical Science Council | Member (Secretary) | / | |
| Programme Committee: Ageing & Degeneration - A Physiological Perspective (Physiological Society) | Chair | / | |
| Programme Committee: Physiology 2015 (Annual Meeting of The Physiological Society), Cardiff, 2015. | Chair | / | |
| Physiological Society: Scientific Programme Committee for Joint Meeting of TPS and APS, Dublin, 2016 | Co-Chair | / | |
| Programme Committee: Biomedical Sciences Annual Meeting, Galway (NUIG), 2012 | Chair | / | |
| Programme Committee: Biomedical Sciences Annual Meeting, Cork (UCC), 2013 | Chair | / | |
| Programme Committee: Biomedical Sciences Annual Meeting, Dublin (UCD), 2014 | Chair | / | |
| Programme Committee: Biomedical Sciences Annual Meeting, Dublin (RCSI), 2015 | Chair | / | |
| University: Academic Council | Member (Professor) | / | |
| University: Research Integrity Officer | Chair | / | |
| University: Governing Body Committee on Students | Member | / | |
| University: Graduate Studies Committee | Member | / | |
| University: Ethics Committee | Member | / | |
| University: Biological Services Unit | Director | / | |
| University: BSU Management Committee | Chair | / | |
| University: BSU Policy Committee | Member | / |
Employment
| Employer | Position | From / To | |
|---|---|---|---|
| University of North Carolina - Chapel Hill | Postdoctoral Fellow | 01-SEP-95 / 31-AUG-96 | |
| University of Wisconsin-Madison, USA | Postdoctoral Fellow | 01-SEP-96 / 01-JUL-00 | |
| University College Dublin | Lecturer/Senior Lecturer | 01-AUG-00 / 30-SEP-11 | |
| University College Cork | Professor of Physiology | 03-OCT-11 / |
Education
| Year | Institution | Qualification | Subject | |
|---|---|---|---|---|
| 1995 | University College Dublin | PhD | Respiratory Physiology | |
| 1992 | University College Cork | BSC (HONS) | Physiology |
Consultancy
| Client | Description | |
|---|---|---|
| Bluebridge Technologies & Covidien |
Outreach Activities
| Description | |
|---|---|
Featured article in Heart & Blood, which was published March 17th and circulated as a supplement in the Irish Independent newspaper. http://www.healthnews.ie/cardiology/high-blood-pressure-in-sleep-apnoea-getting-to-the-heart-of-the-... | |
Irish Times Snoring study: the danger behind the annoyance Interview with Prof. Aidan Bradford (RCSI) http://www.irishtimes.com/news/health/snoring-study-the-danger-behind-the-annoyance-1.905257 | |
Radio interviews on Lyric FM (Culture File) and Newstalk (Futureproof). | |
The Physiological Society (UK & Ireland) | |
UCC College of Science, Enginneering and Food Science Open Days | |
Commentary on science education published in the Sunday Times. |
Journal Activities
| Journal | Role | To / From | |
|---|---|---|---|
| Gene Therapy | Referee | - | |
| Experimental Physiology | Editor | - | |
| Acta Physiologica | Referee | - | |
| Journal Of Comparative Physiology. B, Biochemical, Systemic, And Environmental Physiology | Referee | - | |
| Irish Journal Of Medical Science | Editor | - | |
| Physiology And Behaviour | Referee | - | |
| Cellular And Molecular Biology (Noisy-Le-Grand, France) | Referee | - | |
| Experimental Physiology | Editor | 01-JAN-15 - | |
| Nature Communications | Referee | - | |
| Scientific Reports | Referee | - | |
| Molecular Psychiatry | Referee | - | |
| International Journal Of Molecular Sciences | Referee | - | |
| Molecular Nutrition And Food Research | Referee | - | |
| Autonomic Neuroscience-Basic & Clinical | Referee | - | |
| American Journal Of Physiology - Heart And Circulatory Physiology | Referee | - | |
| Frontiers In Physiology | Member of Editorial Board | - | |
| Acta Neurobiologiae Experimentalis | Referee | - | |
| American Journal Of Physiology. Regulatory, Integrative And Comparative Physiology | Referee | - | |
| American Journal Of Respiratory Cell And Molecular Biology | Referee | - | |
| American Journal Of Respiratory And Critical Care Medicine | Referee | - | |
| Chest | Referee | - | |
| Experimental Physiology | Referee | - | |
| Journal Of Applied Physiology | Referee | - | |
| Journal Of Cell Biochemistry | Referee | - | |
| Journal Of Clinical Investigation | Referee | - | |
| Journal Of Neurophysiology | Referee | - | |
| Journal Of Physiology | Referee | - | |
| Life Sciences | Referee | - | |
| Obesity Research | Referee | - | |
| Oral Diseases | Referee | - | |
| Plos One | Referee | - | |
| Respiratory Physiology & Neurobiology | Referee | - | |
| Respiration | Referee | - |
Teaching Activities
Teaching Interests
UndergraduateFM 1030 / MH 1030 Respiratory Biology & Metabolism
MH 1050 Introduction to Translational Medicine
PL 3001 Pathophysiology
PL 3025 Literature Review, Experimental Design and Data Analysis
PL 3022 Respiratory Physiology
AN 3003 Neurobiology of Regulatory Systems
MH 3010 Systematic Literature Review
PL 4010 Control of Breathing in Health & Disease
PL 4020 Research Project (final year BSc Physiology)
MH 4010 Research Project (final year BSc Medicine & Health)
Postgraduate
DS7100: Basic Science Relevant to Oral Surgery Practice
Recent Postgraduates
| Graduation Year | Student Name | Institution | Degree Type | Thesis Title | |
|---|---|---|---|---|---|
| 2023 | Maria L. Dias Casacao | University College Cork | PHD | A trilogy of stressors in the NICU: Towards therapy for preterm adversity. External examiner: Prof Jyoti Watters, University of Wisconsin-Madison, USA. | |
| 2023 | Jack K. Leacy | University College Cork | PHD | An Exploration into the Effects of High Altitude Exposure on the Neurovascular Coupling Response. External examiners: Prof Phil Ainslie (University of British Columbia, Canada) and Dr Sam Lucas (University of Birmingham, UK). | |
| 2021 | Sara AlMarabeh | University College Cork | PHD | The role of renal afferent signalling in chronic intermittent hypoxia-induced sympathoexcitation and hypertension. External examiner: Dr Carolyn Barrett, University of Auckland, New Zealand. | |
| 2021 | Sarah E. Drummond | University College Cork | PHD | The role of NADPH oxidase-2 in chronic intermittent hypoxia-induced respiratory system dysfunction. External examiners: Prof. Mai Elmallah (Duke University, USA) and Dr Brian McDonagh, NUI Galway, Ireland. | |
| 2021 | Kevin H. Murphy | University College Cork | MSc | Assessment of respiratory motor units in the mdx mouse model of Duchenne muscular dystrophy. External examiner: Professor Aidan Bradford, RCSI, Ireland. | |
| 2020 | Karen M. O'Connor | University College Cork | PHD | Bugs, breathing and blood pressure: The microbiota-gut-brain axis in cardiorepiratory control. External examiner: Prof. Vincent Joseph, Universite Laval, Quebec, Canada. | |
| 2018 | David P. Burns | University College Cork | PHD | Respiratory control in the mdx mouse model of Duchenne muscular dystrophy. External examiner: Professor Gordon S. Mitchell, University of Florida, USA. | |
| 2017 | Paul Brady | University College Cork | PhD | A randomized controlled trial to determine if the addition of capnography to standard monitoring results in a decreased incidence of hypoxaemia during conscious sedation for oral surgery. | |
| 2017 | Alison Barry | University College Cork | MSc | The impact of exercise on immune parameters and cognition in Multiple Sclerosis. External examiner: Dr Susan Coote, University of Limerick. | |
| 2017 | Andrew O'Leary | University College Cork | PHD | Acute hypoxia-induced diaphragm dysfunction is prevented by antioxidant pretreatment. Extern: Dr. Ged Rafferty, King's College, London, UK. | |
| 2017 | Ruth Carey | University College Cork | MSc | Investigation of alterations of excitation-contraction coupling proteins in a rodent model of chronic intermittent hypoxia. Extern: Dr. Holly Shiels, University of Manchester, UK. | |
| 2015 | Philip Lewis | UCC | PhD | Redox remodelling in diaphragm muscle adaptation to chronic sustained hypoxia. Extern: Prof. Hans Hoppeler, University of Bern, Switzerland. | |
| 2014 | Robert Williams | UCC | MSc | Is NADPH oxidase expression increased in rat respiratory muscle following chronic intermittent hypoxia? Extern: Prof. Trevor Day, Mount Royal University, Canada. | |
| 2013 | Eric Lucking | UCD | PhD | The lumbar sympathetic nervous system does not contribute to chronic intermittent hypoxia induced hypertension. Extern: Prof. Janice Marshall, University of Birmingham, UK. | |
| 2013 | Fiona McDonald | UCD | PhD | Sex specific early life programming of respiratory muscle contractility by chronic intermittent hypoxia. Extern: Dr. Lucy Green, University of Southampton, UK. | |
| 2012 | Deirdre Edge | UCD | PhD | Respiratory control in an animal model of sleep-disordered breathing. Extern: Prof. Tracy Baker-Herman, University of Wisconsin-Madison, USA. | |
| 2011 | Han Bing Chow | UCD | MSc | Hypoxic stress in respiratory muscle – a radical view. Extern: Prof. David Fuller, University of Florida, Gainesville, USA. | |
| 2011 | Chrissie Shortt | UCD | PhD | Free radical mediated respiratory muscle dysfunction in a rodent model of sleep-disordered breathing. Extern: Prof. Paul Greenhaff, University of Nottingham, UK. | |
| 2011 | Ruth O'Connell | UCD | PhD | Comparative analysis of neonatal and adult respiratory muscle structure and function in a rodent model of chronic intermittent hypoxia. Extern: Prof. Richard Kinkead, Laval University, Quebec, Canada. | |
| 2011 | Jayne Carberry | UCD | PhD | Respiratory muscle adaptation to chronic hypoxia in early development. Extern: Prof. Stuart Egginton, University of Leeds, UK. | |
| 2010 | J. Richard Skelly | UCD | PhD | Respiratory muscle remodelling in an animal model of sleep-disordered breathing: Protective effects of antioxidant treatment. Extern: Prof. Prem Kumar, University of Birmingham, UK. | |
| 2010 | Clodagh McMorrow | UCD | PhD | Effects of chronic hypoxia on respiratory muscle structure and function. Extern: Prof Mary Morell, Imperial College, London, UK. |
Current Postgraduate Students
| Student | Degree Type | |
|---|---|---|
| Slyne Aoife Dolores | Doctoral Degree |
Research Information
Internal Collaborators
| Name | Institute | Country | |
|---|---|---|---|
| Dr Mohammed Abdulla | Department of Physiology | IRELAND | |
| Dr. Paul Brady | University College Cork Dental School | IRELAND | |
| Dr. Ger Clarke | Department of Psychiatry and Behavioural Sciences | IRELAND | |
| Professor John Cryan | Department of Anatomy & Neuroscience | IRELAND | |
| Professor Eugene Dempsey | Cork University Maternity Hospital | IRELAND | |
| Dr. Fiona McDonald | Department of Physiology | IRELAND |
External Collaborators
| Name | Organisation / Institute | Country | |
|---|---|---|---|
| Professor Trevor Day | Mount Royal University | CANADA | |
| Professor Mark Evans | University of Edinburgh | UNITED KINGDOM | |
| Professor Dave Fuller | University of Florida | U.S.A. | |
| Dr Kasia Whysall | National University of Ireland, Galway | IRELAND | |
| Professor Richard Wilson | University of Calgary | CANADA |
Contact details
- Ken O'Halloran
Professor of Physiology, Head of Department - k.ohalloran@ucc.ie
- Lab 1.02, Western Gateway Building
Western Road
Cork - +353-87-7855821