Research Profile

Maria Buckley

Biography

Dr Maria M Buckley Is a Lecturer in Pharmacology & Therapeutics. She received a BSc (Hons) in Physiology, UCC in 2005 and continued in the Department of Physiology with her doctoral studies in the laboratory of Professor Johns investigating the neural control of the kidney in heart hypertrophy. She subsequently undertook a research assistant post in the Laboratory of Neurogastroenterology, in the APC Microbiome Institute, UCC, with Dr O’Malley. She returned to the Department of Physiology in 2012, firstly as an assistant lecturer, and then as a postdoctoral researcher.
Thereafter, she undertook postdoctoral research in the APC Microbiome Ireland and the Department of Physiology focusing on the measurement of vagal nerve activity in response to probiotics, before moving to the Department of Psychiatry and Neurobehavioural Science & APC Microbiome Ireland as a Senior Postdoctoral researcher examining the psychology and biology of stress in informal dementia caregivers.

Publications

Peer Reviewed Journals

 YearPublication
(2019)'Heparan sulphate and hylauronic acid components of the glycocalyx do not play a role in flow mediated dilation of the iliac in the anaesthetized pig'
Ruane-O'Hora T;O'Malley D;Buckley MM;Markos F; (2019) 'Heparan sulphate and hylauronic acid components of the glycocalyx do not play a role in flow mediated dilation of the iliac in the anaesthetized pig'. Canadian Journal of Physiology and Pharmacology, [DOI] [Details]
(2019)'PI 3-kinase- and ERK-MAPK-dependent mechanisms underlie Glucagon-Like Peptide-1-mediated activation of Sprague Dawley colonic myenteric neurons'
O'Brien, Rebecca; Buckley, Maria M.; Kelliher, Amy; O'Malley, Dervla (2019) 'PI 3-kinase- and ERK-MAPK-dependent mechanisms underlie Glucagon-Like Peptide-1-mediated activation of Sprague Dawley colonic myenteric neurons'. Neurogastroenterology and Motility, :1-11   [DOI] [Full Text] [Details]
(2019)'GHSR-1 agonist sensitizes rat colonic intrinsic and extrinsic neurons to exendin-4: A role in the manifestation of postprandial gastrointestinal symptoms in irritable bowel syndrome?'
Buckley, Maria M.; O'Brien, Rebecca; Buckley, Julliette M.; O'Malley, Dervla (2019) 'GHSR-1 agonist sensitizes rat colonic intrinsic and extrinsic neurons to exendin-4: A role in the manifestation of postprandial gastrointestinal symptoms in irritable bowel syndrome?'. Neurogastroenterology and Motility, :1-13   [DOI] [Full Text] [Details]
(2018)'Development of an ex Vivo Method for Multi-unit Recording of Microbiota-Colonic-Neural Signaling in Real Time'
Buckley, MM;O'Malley, D (2018) 'Development of an ex Vivo Method for Multi-unit Recording of Microbiota-Colonic-Neural Signaling in Real Time'. Frontiers in neuroscience, 12 [DOI] [Details]
(2017)'Combined xIL-6R and urocortin-2 treatment restores mdx diaphragm muscle force'
Manning J, Buckley MM, O'Halloran KD, O'Malley D (2017) 'Combined xIL-6R and urocortin-2 treatment restores mdx diaphragm muscle force'. Muscle & Nerve, :1-7   [DOI] [Full Text] [Details]
(2016)'Leptin modifies the prosecretory and prokinetic effects of the inflammatory cytokine interleukin-6 on colonic function in Sprague–Dawley rats'
Buckley, Maria M.; O'Brien, Rebecca; Devlin, Michelle; Creed, Aisling A.; Rae, Mark G.; Hyland, Niall P.; Quigley, Eamonn M. M.; McKernan, Declan P.; O'Malley, Dervla (2016) 'Leptin modifies the prosecretory and prokinetic effects of the inflammatory cytokine interleukin-6 on colonic function in Sprague–Dawley rats'. Experimental Physiology, 101 (12):1477-1491 [DOI] [Full Text] [Details]
(2016)'In vivo neutralization of IL-6 receptors ameliorates gastrointestinal dysfunction in dystrophin-deficient mdx mice'
Manning, J;Buckley, MM;O'Halloran, KD;O'Malley, D (2016) 'In vivo neutralization of IL-6 receptors ameliorates gastrointestinal dysfunction in dystrophin-deficient mdx mice'. Neurogastroenterology and Motility, 28 :1016-1026 [DOI] [Details]
(2016)'In vivo neutralisation of IL-6 receptors ameliorates gastrointestinal dysfunction in dystrophin-deficient mdx mice'
Manning J, Buckley MM, O'Halloran KD, O'Malley D (2016) 'In vivo neutralisation of IL-6 receptors ameliorates gastrointestinal dysfunction in dystrophin-deficient mdx mice'. Neurogastroenterology and Motility, 28 (7):1016-1026 [Details]
(2016)'Leptin modifies the prosecretory and prokinetic effects of the inflammatory cytokine interleukin-6 on colonic function in Sprague-Dawley rats'
Buckley, MM;O'Brien, R;Devlin, M;Creed, AA;Rae, MG;Hyland, NP;Quigley, EMM;McKernan, DP;O'Malley, D (2016) 'Leptin modifies the prosecretory and prokinetic effects of the inflammatory cytokine interleukin-6 on colonic function in Sprague-Dawley rats'. Experimental Physiology, 101 :1477-1491 [DOI] [Details]
(2015)'IBS plasma sensitises colonic submucosal neurons to glp-1-evoked activation'
O'Brien, R,Buckley, M,O'Malley, D (2015) 'IBS plasma sensitises colonic submucosal neurons to glp-1-evoked activation'. Neurogastroenterology and Motility, 27 :112-112 [Details]
(2014)'Modulation of enteric neurons by interleukin-6 and corticotropin-releasing factor contributes to visceral hypersensitivity and altered colonic motility in a rat model of irritable bowel syndrome'
Buckley, MM,O'Halloran, KD,Rae, MG,Dinan, TG,O'Malley, D (2014) 'Modulation of enteric neurons by interleukin-6 and corticotropin-releasing factor contributes to visceral hypersensitivity and altered colonic motility in a rat model of irritable bowel syndrome'. Journal of Physiology-London, 592 :5235-5250 [DOI] [Details]
(2014)'Convergence of neuro-endocrine-immune pathways in the pathophysiology of irritable bowel syndrome'
Buckley, MM;O'Mahony, SM;O'Malley, D (2014) 'Convergence of neuro-endocrine-immune pathways in the pathophysiology of irritable bowel syndrome'. World Journal of Gastroenterology, 20 :8846-8858 [DOI] [Details]
(2014)'Modulation of enteric neurons by Interleukin‐6 and CRF contributes to visceral hypersensitivity and altered colonic motility in a rat model of Irritable Bowel Syndrome'
Buckley MM, O'Halloran KD, Rae MG, Dinan TG, and O'Malley D (2014) 'Modulation of enteric neurons by Interleukin‐6 and CRF contributes to visceral hypersensitivity and altered colonic motility in a rat model of Irritable Bowel Syndrome'. Journal of Physiology, 592 :5235-5250 [Details]
(2014)'Soluble mediators in plasma from irritable bowel syndrome patients excite rat submucosal neurons'
O'Malley D, Buckley MM, McKernan DP, Quigley EM, Cryan JF, Dinan TG (2014) 'Soluble mediators in plasma from irritable bowel syndrome patients excite rat submucosal neurons'. Brain Behav Immun, [DOI] [Details]
(2014)'Soluble mediators in plasma from irritable bowel syndrome patients excite rat submucosal neurons'
O'Malley, D.,Buckley, M. M.,McKernan, D. P.,Quigley, E. M.,Cryan, J. F.,Dinan, T. G. (2014) 'Soluble mediators in plasma from irritable bowel syndrome patients excite rat submucosal neurons'. Brain Behav Immun,   [Details]
(2011)'Impact of L-NAME on the cardiopulmonary reflex in cardiac hypertrophy'
Buckley, MM;Johns, EJ (2011) 'Impact of L-NAME on the cardiopulmonary reflex in cardiac hypertrophy'. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 301 :1549-1556 [DOI] [Details]
(2011)'Impact of L-NAME on the cardiopulmonary reflex in cardiac hypertrophy'
Buckley, MM,Johns, EJ (2011) 'Impact of L-NAME on the cardiopulmonary reflex in cardiac hypertrophy'. American Journal of Physiology, 301 :1549-1556 [DOI] [Details]
(2008)'Impact of Cardiac Hypertrophy On Arterial and Cardiopulmonary Baroreflex Control of Renal Sympathetic Nerve Activity In Anaesthetized Rats'
Flanagan, ET, Buckley, MM, Aherne, CM, Lainis, F, Sattar, M, Johns, EJ; (2008) 'Impact of Cardiac Hypertrophy On Arterial and Cardiopulmonary Baroreflex Control of Renal Sympathetic Nerve Activity In Anaesthetized Rats'. Experimental Physiology, 93 (9):1058-1064 [DOI] [Details]
(2008)'Impact of cardiac hypertrophy on arterial and cardiopulmonary baroreflex control of renal sympathetic nerve activity in anaesthetized rats'
Flanagan ET, Buckley MM, Aherne CM, Lainis F, Sattar M, Johns EJ; (2008) 'Impact of cardiac hypertrophy on arterial and cardiopulmonary baroreflex control of renal sympathetic nerve activity in anaesthetized rats'. Experimental Physiology, 93 (9):1058-1064 [DOI] [Details]
(2008)'Impact of cardiac hypertrophy on arterial and cardiopulmonary baroreflex control of renal sympathetic nerve activity in anaesthetized rats'
Flanagan, ET,Buckley, MM,Aherne, CM,Lainis, F,Sattar, M,Johns, EJ; (2008) 'Impact of cardiac hypertrophy on arterial and cardiopulmonary baroreflex control of renal sympathetic nerve activity in anaesthetized rats'. Experimental Physiology, 93 :1058-1064 [DOI] [Details]

Book Chapters

 YearPublication
(2015)'Convergence of Neuro-Endocrine-Immune Pathways in the Pathophysiology of Irritable Bowel Syndrome'
Buckley M, O’Mahony SM and O’Malley D (2015) 'Convergence of Neuro-Endocrine-Immune Pathways in the Pathophysiology of Irritable Bowel Syndrome' In: Advances in Irritable Bowel Syndrome. California, USA: Baishideng Publishing Group. [Details]

Conference Publications

 YearPublication
(2014)Little Brain Big Brain
Buckley, MM,O'Malley, D (2014) Interleukin-6 and corticotropin-releasing factor contribute to visceral pain and colonic transit in the Wistar Kyoto rat model of Irritable Bowel Syndrome Little Brain Big Brain [Details]
(2014)RAMI
Buckley, MM,O'Malley, D (2014) Changes in colonic mucosal protein expression underlies the therapeutic benefits of anti-IL-6R and antalarmin on IBS-like symptoms in the WKY rat RAMI [Details]
(2014)Physiological Society - Obesity meeting
Buckley, MM, Devlin M, Blake A, O'Malley, D (2014) Crosstalk between leptin and interleukin-6 in the pathophysiology of Irritable Bowel Syndrome Physiological Society - Obesity meeting [Details]
(2014)Physiological Society
Buckley, MM,O'Malley, D (2014) Immune and Stress factors alter colonic contractile activity Physiological Society [Details]
(2014)Federation of Neurogastroenterology and Motility
Buckley, MM,O'Malley, D (2014) Interleukin-6 and corticotropin-releasing factor contribute to visceral pain and colonic transit in the Wistar Kyoto rat model of Irritable Bowel Syndrome Federation of Neurogastroenterology and Motility [Details]
(2013)Dietary Disease Week
Buckley, M and O’Malley, D. (2013) Inhibition of Interleukin-6 signalling suppresses visceral pain sensitivity and stress-induced defecation in the Wistar Kyoto rat model of IBS Dietary Disease Week [Details]
(2013)RAMI
Kelliher A, O’Sullivan L, Buckley M and O’Malley D. (2013) Crosstalk between GLP-1 and IL-6 in isolated rat myenteric and submucosal neurons RAMI [Details]
(2013)RAMI
Buckley MM and O’Malley D. (2013) Visceral pain sensitivity and stress-induced defecation in the Wistar Kyoto rat model of IBS is suppressed by inhibition of interleukin-6 signalling RAMI [Details]
(2013)Irish Journal of Medical Science
Buckley, MM,O'Malley, D (2013) Rat myenteric neurons are activated by immune factors in irritable bowel syndrome plasma Irish Journal of Medical Science , pp.121-121 [Details]
(2012)Neurogastroenterology & Motility
Buckley M & O’Malley D (2012) Immune factors in irritable bowel syndrome plasma activate rat myenteric neurons Neurogastroenterology & Motility Neurogastroenterology and Motility, , 06-SEP-12 - 09-SEP-12 [Details]
(2012)Neurogastroenterology & Motility
Buckley, M,Dinan, TG,O'Malley, D (2012) Immune factors in Irritable Bowel Syndrome plasma activate rat myenteric neurons Neurogastroenterology & Motility , pp.64-64 [Details]
(2009)Physiological Society General Meeting
Buckley, M Brennan, D and Johns, E; (2009) Renal excretory responses to a volume load in conscious Wistar rats with heart hypertrophy Physiological Society General Meeting Dublin, , 01-JUL-09 - 04-JUL-09 [Details]
(2009)Physiological Society Meeting
Lainis, F, Buckley, M and Johns, E.; (2009) Thyroxine induced heart hypertrophy: impact on cardiac function Physiological Society Meeting Dublin, , 01-JUL-09 - 04-JUL-09 [Details]

Abstract

 YearPublication
(2018)INFORMAL CAREGIVING FOR DEMENTIA PATIENTS: THE CONTRIBUTION OF PATIENT AGE, COGNITIVE AND FUNCTIONAL IMPAIRMENT AND CHALLENGING BEHAVIOURS TO CAREGIVER BURDEN.
Allen, AP;Buckley, M;Chorcorain, AN;Cryan, JF;Dinan, TG;Kearney, P;Clarke, G;Molloy, DW (2018) INFORMAL CAREGIVING FOR DEMENTIA PATIENTS: THE CONTRIBUTION OF PATIENT AGE, COGNITIVE AND FUNCTIONAL IMPAIRMENT AND CHALLENGING BEHAVIOURS TO CAREGIVER BURDEN. OXFORD: Abstract [DOI] [Details]
(2017)Vagal nerve activity is stimulated by GABA-secreting probiotics signalling across the colonic mucosal barrier.
Buckley, M;O'Driscoll, G;Stanton, C;O'Malley, D (2017) Vagal nerve activity is stimulated by GABA-secreting probiotics signalling across the colonic mucosal barrier. HOBOKEN: Abstract [Details]
(2017)Ghrelin sensitises colonic myenteric neurons to the neurostimulatory effects of Glucagon-like peptide-1.
O'Brien, R;Buckley, MM;Barry-Murphy, K;O' Malley, D (2017) Ghrelin sensitises colonic myenteric neurons to the neurostimulatory effects of Glucagon-like peptide-1. HOBOKEN: Abstract [Details]
(2017)Ghrelin enhances GLP-1 induced neuronal activation in the distal colon.
Buckley, M;O'Brien, R;O'Malley, D (2017) Ghrelin enhances GLP-1 induced neuronal activation in the distal colon. HOBOKEN: Abstract [Details]
(2017)A GLP-1 mimetic alleviates irritable bowel syndrome-like symptoms in the Wistar Kyoto rat.
O'Brien, R;Buckley, MM;O'Halloran, K;O'Malley, D (2017) A GLP-1 mimetic alleviates irritable bowel syndrome-like symptoms in the Wistar Kyoto rat. HOBOKEN: Abstract [Details]
(2017)L-cells are key to cross-barrier signalling to the host peripheral nervous system by a GLP-1-secreting putative probiotic.
Brosnan, E;O'Malley, D;O'Malley, D;Buckley, M;Ross, RP;Stanton, C (2017) L-cells are key to cross-barrier signalling to the host peripheral nervous system by a GLP-1-secreting putative probiotic. HOBOKEN: Abstract [Details]
(2017)Bifidobacterium Breve NCFB 2258 stimulates vagal nerve firing across an intact colonic barrier.
O'Malley, D;Buckley, M;Leahy, A;Stanton, C (2017) Bifidobacterium Breve NCFB 2258 stimulates vagal nerve firing across an intact colonic barrier. HOBOKEN: Abstract [DOI] [Details]
(2016)Crosstalk Between GLP-1 and IL-6 in Isolated Rat Myenteric and Submucosal Neurons.
Kelliher, A;O'Sullivan, L;Buckley, M;O'Malley, D (2016) Crosstalk Between GLP-1 and IL-6 in Isolated Rat Myenteric and Submucosal Neurons. LONDON: Abstract [Details]
(2016)Immune and Stress Factors Alter Gut Nerve Activity.
Buckley, MM;O'Malley, D (2016) Immune and Stress Factors Alter Gut Nerve Activity. LONDON: Abstract [Details]
(2016)A GLP-1 Mimetic Alleviates Irritable Bowel Syndrome-like Symptoms in the Wistar Kyoto Rat.
O'Brien, R;Buckley, MM;O'Halloran, KD;O'Malley, D (2016) A GLP-1 Mimetic Alleviates Irritable Bowel Syndrome-like Symptoms in the Wistar Kyoto Rat. BETHESDA: Abstract [Details]
(2016)Changes in Colonic Mucosal Protein Expression Underlies the Therapeutic Benefits of Anti-IL-6R and Antalarmin on IBS-Like Symptoms in the Wistar Kyoto Rat.
Buckley, MM;O'Malley, D (2016) Changes in Colonic Mucosal Protein Expression Underlies the Therapeutic Benefits of Anti-IL-6R and Antalarmin on IBS-Like Symptoms in the Wistar Kyoto Rat. LONDON: Abstract [Details]
(2016)Visceral Pain Sensitivity and Stress-Induced Defecation in the Wistar Kyoto Rat Model of IBS is Suppressed by Inhibition of Interleukin-6 Signalling.
Buckley, MM;O'Malley, D (2016) Visceral Pain Sensitivity and Stress-Induced Defecation in the Wistar Kyoto Rat Model of IBS is Suppressed by Inhibition of Interleukin-6 Signalling. LONDON: Abstract [Details]
(2016)Immune and stress factors in the distal colon alter vagal nerve activity.
Buckley, MM;O'Malley, D (2016) Immune and stress factors in the distal colon alter vagal nerve activity. HOBOKEN: Abstract [Details]
(2015)The obesity hormone leptin may protect against Irritable Bowel Syndrome pathophysiology.
Omalley, D;Obrien, R;Buckley, M (2015) The obesity hormone leptin may protect against Irritable Bowel Syndrome pathophysiology. HOBOKEN: Abstract [Details]
(2015)IBS plasma sensitises colonic submucosal neurons to glp-1-evoked activation.
O'Brien, R;Buckley, M;O'Malley, D (2015) IBS plasma sensitises colonic submucosal neurons to glp-1-evoked activation. HOBOKEN: Abstract [Details]
(2014)Interleukin-6 and Corticotropin-Releasing Factor contribute to visceral pain and colonic transit in the Wistar Kyoto rat model of Irritable Bowel Syndrome.
Buckley, M,O'Malley, D (2014) Interleukin-6 and Corticotropin-Releasing Factor contribute to visceral pain and colonic transit in the Wistar Kyoto rat model of Irritable Bowel Syndrome. Abstract [Details]
(2014)Interleukin-6 and Corticotropin-Releasing Factor contribute to visceral pain and colonic transit in the Wistar Kyoto rat model of Irritable Bowel Syndrome.
Buckley, M;O'Malley, D (2014) Interleukin-6 and Corticotropin-Releasing Factor contribute to visceral pain and colonic transit in the Wistar Kyoto rat model of Irritable Bowel Syndrome. HOBOKEN: Abstract [Details]
(2013)Rat myenteric neurons are activated by immune factors in irritable bowel syndrome plasma.
Buckley, MM;O'Malley, D (2013) Rat myenteric neurons are activated by immune factors in irritable bowel syndrome plasma. LONDON: Abstract [Details]
(2012)Catecholamine-Induced Heart Hypertrophy: Impact on Cardiac Function.
Lainis, F;Buckley, MM;Johns, EJ (2012) Catecholamine-Induced Heart Hypertrophy: Impact on Cardiac Function. LONDON: Abstract [Details]
(2012)Immune factors in Irritable Bowel Syndrome plasma activate rat myenteric neurons.
Buckley, M;Dinan, TG;O'Malley, D (2012) Immune factors in Irritable Bowel Syndrome plasma activate rat myenteric neurons. HOBOKEN: Abstract [Details]
(2012)Thyroxine-Induced Heart Hypertrophy: Impact on Cardiac Function.
Lainis, F,Buckley, MM,Johns, EJ (2012) Thyroxine-Induced Heart Hypertrophy: Impact on Cardiac Function. Abstract [Details]
(2012)Catecholamine-Induced Heart Hypertrophy: Impact on Cardiac Function.
Lainis, F,Buckley, MM,Johns, EJ (2012) Catecholamine-Induced Heart Hypertrophy: Impact on Cardiac Function. Abstract [Details]
(2012)Thyroxine-Induced Heart Hypertrophy: Impact on Cardiac Function.
Lainis, F;Buckley, MM;Johns, EJ (2012) Thyroxine-Induced Heart Hypertrophy: Impact on Cardiac Function. LONDON: Abstract [Details]
(2009)Neural control of the kidney in a thyroxine induced model of heart hypertrophy (HH): impact of Nitric Oxide Synthase (NOS) blockade.
Buckley, MM,Johns, EJ (2009) Neural control of the kidney in a thyroxine induced model of heart hypertrophy (HH): impact of Nitric Oxide Synthase (NOS) blockade. Abstract [Details]
(2009)Neural control of the kidney in a thyroxine induced model of heart hypertrophy (HH): impact of Nitric Oxide Synthase (NOS) blockade.
Buckley, MM;Johns, EJ (2009) Neural control of the kidney in a thyroxine induced model of heart hypertrophy (HH): impact of Nitric Oxide Synthase (NOS) blockade. BETHESDA: Abstract [Details]
(2006)Neural regulation of the kidney in rats with heart hypertrophy: impact of nitric oxide (NO).
Johns, EJ;Buckley, MM (2006) Neural regulation of the kidney in rats with heart hypertrophy: impact of nitric oxide (NO). BETHESDA: Abstract [Details]
(2006)Neural regulation of the kidney in rats with heart hypertrophy: impact of nitric oxide (NO).
Johns, EJ,Buckley, MM (2006) Neural regulation of the kidney in rats with heart hypertrophy: impact of nitric oxide (NO). Abstract [Details]

Professional Activities

Conference Contributions

 YearPublication
(2012)Immune factors in irritable bowel syndrome plasma activate rat myenteric neurons,
Buckley M & O'Malley D (2012) Oral presentation. [Oral Presentation], Immune factors in irritable bowel syndrome plasma activate rat myenteric neurons, RAMI Galway , 28-JUN-12 - 29-JUN-12. [Details]

Committees

 CommitteeFunctionFrom / To
Equality Committee Committee member/
Research Staff Association Membership officer/

Education

 YearInstitutionQualificationSubject
2011University College Cork Phd MedicinePhysiology
2005University College Cork BSc HonoursPhysiology

Journal Activities

 JournalRoleTo / From
Faseb Journal : Official Publication Of The Federation Of American Societies For Experimental Biology Referee-
Journal Of Pharmacy And Pharmacology Referee-
Brain Behav Immun Referee-

Teaching Activities

Modules Taught

 Term (ID))TitleLinkSubject
2020Introduction to Toxicology PT2020Introduction to Toxicology

Contact details


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