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4. Farouk Hazim Markos

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Biography

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Research Interests

My research interests are in the field of integrated cardiovascular physiology and pharmacology, with a focus currently on vascular biology. 
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Publications

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Peer Reviewed Journals

	Year	Publication
	(2018)	'The Arteriolar Glycocalyx Plays a Role in the Regulation of Blood Flow in the Iliac of the Anaesthetised Pig' Ruane-O'Hora, T;Markos, F (2018) 'The Arteriolar Glycocalyx Plays a Role in the Regulation of Blood Flow in the Iliac of the Anaesthetised Pig'. Physiological Research, 67 :41-44 [Details]
	(2017)	'Assessment of renal function in the anaesthetised rat following injection of superparamagnetic iron oxide nanoparticles' Edge D, Shortt CM, Johns EJ, Gobbo OL, Markos F, Abdulla MH, Barry EF. (2017) 'Assessment of renal function in the anaesthetised rat following injection of superparamagnetic iron oxide nanoparticles'. Canadian Journal of Physiology and Pharmacology, 95 (4):443-446 [DOI] [Details]
	(2016)	'Pharmacokinetics and bio-distribution of novel super paramagnetic iron oxide nanoparticles (SPIONs) in the anaesthetized pig' Edge, D;Shortt, CM;Gobbo, OL;Teughels, S;Prina-Mello, A;Volkov, Y;MacEneaney, P;Radomski, MW;Markos, F (2016) 'Pharmacokinetics and bio-distribution of novel super paramagnetic iron oxide nanoparticles (SPIONs) in the anaesthetized pig'. Clinical and experimental pharmacology & physiology, 43 :319-326 [DOI] [Details]
	(2015)	'Biodistribution and pharmacokinetic studies of SPION using particle electron paramagnetic resonance, MRI and ICP-MS' Gobbo, OL,Wetterling, F,Vaes, P,Teughels, S,Markos, F,Edge, D,Shortt, CM,Crosbie-Staunton, K,Radomski, MW,Volkov, Y,Prina-Mello, A (2015) 'Biodistribution and pharmacokinetic studies of SPION using particle electron paramagnetic resonance, MRI and ICP-MS'. Nanomedicine, 10 :1751-1760 [DOI] [Details]
	(2014)	'Immediate Direct Peripheral Vasoconstriction in Response to Hyperinsulinemia and Metformin in the Anesthetized Pig' Markos, F;Shortt, CM;Edge, D;Ruane-O'Hora, T;Noble, MIM (2014) 'Immediate Direct Peripheral Vasoconstriction in Response to Hyperinsulinemia and Metformin in the Anesthetized Pig'. Physiological Research, 63 :559-566 [Details]
	(2013)	'Intraluminal hyperglycaemia causes conduit and resistance artery dilatation and inhibits vascular autoregulation in the anaesthetised pig' Ruane-O'Hora, T,Shortt, CM,Edge, D,Markos, F,Noble, MIM (2013) 'Intraluminal hyperglycaemia causes conduit and resistance artery dilatation and inhibits vascular autoregulation in the anaesthetised pig'. Canadian Journal of Physiology and Pharmacology, 91 :1031-1036 [DOI] [Details]
	(2013)	'Responses of iliac conduit artery and hindlimb resistance vessels to luminal hyperfructosemia in the anaesthetized pig' Ruane-O'Hora, T,Edge, D,Shortt, CM,Markos, F,Noble, MIM (2013) 'Responses of iliac conduit artery and hindlimb resistance vessels to luminal hyperfructosemia in the anaesthetized pig'. Acta Physiologica, 209 :254-261 [DOI] [Details]
	(2013)	'What is the mechanism of flow-mediated arterial dilatation' Markos, F,O'Hora, TR,Noble, MIM (2013) 'What is the mechanism of flow-mediated arterial dilatation'. Clinical and Experimental Pharmacology and Physiology, 40 :489-494 [DOI] [Details]
	(2012)	'Dependence of smooth muscle tone upon pulsatility in the iliac artery of the anaesthetised pig' Markos, F;O'Hora, TR;Wainwright, CL;Noble, MIM (2012) 'Dependence of smooth muscle tone upon pulsatility in the iliac artery of the anaesthetised pig'. Pflugers Archiv-European Journal Of Physiology, 463 :679-684 [DOI] [Details]
	(2012)	'Metformin Causes Nitric Oxide-mediated Dilatation in a Shorter Time Than Insulin in the Iliac Artery of the Anesthetized Pig' O'Hora, TR,Markos, F,Wiernsperger, NF,Noble, MIM (2012) 'Metformin Causes Nitric Oxide-mediated Dilatation in a Shorter Time Than Insulin in the Iliac Artery of the Anesthetized Pig'. Journal of Cardiovascular Pharmacology, 59 :182-187 [DOI] [Details]
	(2011)	'The effect of alphaxalone-alphadolone, propofol, and pentobarbitone anaesthesia on the beta-endorphin and ACTH response to haemorrhage in the pig' Ruane-O'Hora, T;Hall, WJ;Markos, F (2011) 'The effect of alphaxalone-alphadolone, propofol, and pentobarbitone anaesthesia on the beta-endorphin and ACTH response to haemorrhage in the pig'. Canadian Journal of Physiology and Pharmacology, 89 :521-526 [DOI] [Details]
	(2011)	'Effect of clazosentan, a selective endothelin A receptor antagonist, and tezosentan, a dual endothelin A/B antagonist, on pulsatile shear stress induced constriction of the iliac in the anaesthetized pig' Ruane-O'Hora, T;Rae, MG;Markos, F (2011) 'Effect of clazosentan, a selective endothelin A receptor antagonist, and tezosentan, a dual endothelin A/B antagonist, on pulsatile shear stress induced constriction of the iliac in the anaesthetized pig'. Clinical and experimental pharmacology & physiology, 38 :515-520 [DOI] [Details]
	(2009)	'The Effect of Ketamine and Saffan on the beta-Endorphin and ACTH Response to Hemorrhage in the Minipig' Ruane-O'Hora, T;Hall, WJ;Markos, F (2009) 'The Effect of Ketamine and Saffan on the beta-Endorphin and ACTH Response to Hemorrhage in the Minipig'. Physiological Research, 58 :799-805 [Details]
	(2008)	'Dilatation in the femoral vascular bed does not cause retrograde relaxation of the iliac artery in the anaesthetized pig' Markos, F;Ruane-O'Hora, T;Snow, HM;Kelly, R;Wainwright, C;Skene, K;Drake-Holland, AJ;Noble, MIM (2008) 'Dilatation in the femoral vascular bed does not cause retrograde relaxation of the iliac artery in the anaesthetized pig'. Acta Physiologica, 194 :207-213 [DOI] [Details]
	(2007)	'Muscarinic type 1 receptors mediate part of nitric oxide's vagal facilitatory effect in the isolated innervated rat right atrium' Hogan K & Markos F ; (2007) 'Muscarinic type 1 receptors mediate part of nitric oxide's vagal facilitatory effect in the isolated innervated rat right atrium'. Nitric Oxide, [Details]
	(2007)	'N-desmethylclozapine an M1 receptor agonist enhances nitric oxide's cardiac vagal facilitation in the isolated innervated rat right atrium' Hogan, K,Ahmed, O,Markos, F; (2007) 'N-desmethylclozapine an M1 receptor agonist enhances nitric oxide's cardiac vagal facilitation in the isolated innervated rat right atrium'. Autonomic Neuroscience-Basic & Clinical, 137 :51-55 [DOI] [Details]
	(2006)	'Vagal postganglionic origin of vasoactive intestinal polypeptide (VIP) mediating the vagal tachycardia' Markos, F;Snow, HM (2006) 'Vagal postganglionic origin of vasoactive intestinal polypeptide (VIP) mediating the vagal tachycardia'. European Journal of Applied Physiology, 98 :419-422 [DOI] [Details]
	(2006)	'An investigation into the presence of a vagal tachycardia and the effect of vasoactive intestinal polypeptide on rat heart rate in vitro' Hogan K & Markos F ; (2006) 'An investigation into the presence of a vagal tachycardia and the effect of vasoactive intestinal polypeptide on rat heart rate in vitro'. European Journal of Pharmacology, [Details]
	(2006)	'). Vasoactive intestinal polypeptide receptor antagonism enhances the vagally induced increase in cardiac interval of the rat atrium in vitro' Hogan K & Markos F ; (2006) '). Vasoactive intestinal polypeptide receptor antagonism enhances the vagally induced increase in cardiac interval of the rat atrium in vitro'. Experimental Physiology, [Details]
	(2006)	'An investigation into the physiological relevance of the vagal tachycardia in the anaesthetized dog' Markos, F;Snow, HM (2006) 'An investigation into the physiological relevance of the vagal tachycardia in the anaesthetized dog'. Acta Physiologica, 186 :179-184 [DOI] [Details]
	(2005)	'Aldosterone Rapidly Activates Na+/H+ Exchange in M-1 Cortical Collecting Duct Cells via a PKC-MAPK Pathway' Markos F, Healy V & Harvey BJ ; (2005) 'Aldosterone Rapidly Activates Na+/H+ Exchange in M-1 Cortical Collecting Duct Cells via a PKC-MAPK Pathway'. Nephron Physiology,   [DOI] [Details]
	(2004)	'The role of neuronal nitric oxide (NO) in the vagal control of cardiac interval of the rat heart in vitro' Sweeney C & Markos F ; (2004) 'The role of neuronal nitric oxide (NO) in the vagal control of cardiac interval of the rat heart in vitro'. Autonomic Neuroscience: Basic & Clinical, [Details]
	(2003)	'The efficacy of nicorandil, calcium chloride and nitroglycerin in treatment of ropivacaine-induced cardiotoxicity' Porter J, Markos F, Snow HM & Shorten G ; (2003) 'The efficacy of nicorandil, calcium chloride and nitroglycerin in treatment of ropivacaine-induced cardiotoxicity'. European Journal of Anaesthesiology, [Details]
	(2003)	'Effects of fenoldopam on renal blood flow and its function in a canine model of rhabdomyolysis' Murray C, Markos F, Snow HM, Corcoran T, Parfrey N, Shorten GD; (2003) 'Effects of fenoldopam on renal blood flow and its function in a canine model of rhabdomyolysis'. European Journal of Anaesthesiology, 20 (9):711-718 [Details]
	(2002)	'An investigation into the mechanism of action of almitrine on isolated rat diaphragm muscle fatigue' Markos, F;Campion, DP;Carey, M;O'Connor, JJ (2002) 'An investigation into the mechanism of action of almitrine on isolated rat diaphragm muscle fatigue'. Respiration, 69 :339-343 [Details]
	(2002)	'An evaluation of the efficacy of vasoactive intestinal polypeptide antagonists in vivo in the anaesthetized dog' Markos, F;Hennessy, BA;Fitzpatrick, M;O'Sullivan, J;Snow, HM (2002) 'An evaluation of the efficacy of vasoactive intestinal polypeptide antagonists in vivo in the anaesthetized dog'. Pharmacology, 66 :206-210 [DOI] [Details]
	(2002)	'Reverse arterial wall shear stress causes nitric oxide-dependent vasodilatation in the anaesthetised dog' Markos, F;Hennessy, BA;Fitzpatrick, M;O'Sullivan, J;Snow, HM (2002) 'Reverse arterial wall shear stress causes nitric oxide-dependent vasodilatation in the anaesthetised dog'. Pflugers Archiv-European Journal Of Physiology, 445 :51-54 [DOI] [Details]
	(2002)	'Nitric oxide facilitates vagal control of heart rate via actions in the cardiac parasympathetic ganglia of the anaesthetised dog' Markos, F,Snow, HM,Kidd, C,Conlon, K; (2002) 'Nitric oxide facilitates vagal control of heart rate via actions in the cardiac parasympathetic ganglia of the anaesthetised dog'. Experimental Physiology, 87 :49-52 [Details]
	(2002)	'The effect of tezosentan, a non-selective endothelin receptor antagonist, on shear stress-induced changes in arterial diameter of the anaesthetized dog' Markos, F,Hennessy, BA,Fitzpatrick, M,O'Sullivan, J,Snow, HM; (2002) 'The effect of tezosentan, a non-selective endothelin receptor antagonist, on shear stress-induced changes in arterial diameter of the anaesthetized dog'. Journal of Physiology-London, 544 :913-918 [DOI] [Details]
	(2001)	'The potentiation of sinus arrhythmia by vasoactive intestinal polypeptide (VIP) in the anaesthetized dog' Markos, F;Snow, HM (2001) 'The potentiation of sinus arrhythmia by vasoactive intestinal polypeptide (VIP) in the anaesthetized dog'. Neuropeptides, 35 :238-243 [DOI] [Details]
	(2001)	'Characteristics of arterial wall shear stress which cause endothelium-dependent vasodilatation in the anaesthetized dog' Snow, HM;Markos, F;O'Regan, D;Pollock, K (2001) 'Characteristics of arterial wall shear stress which cause endothelium-dependent vasodilatation in the anaesthetized dog'. Journal of Physiology-London, 531 :843-848 [Details]
	(2001)	'Effects of prophylactic fenoldopam infusion on renal blood flow and venal tubular function during acute hypovolemia in anesthetized dogs' Halpenny, M;Markos, F;Snow, HM;Duggan, PF;Gaffney, E;O'Connell, DP;Shorten, GD (2001) 'Effects of prophylactic fenoldopam infusion on renal blood flow and venal tubular function during acute hypovolemia in anesthetized dogs'. Critical Care Medicine, 29 :855-860 [Details]
	(2001)	'Inhibition of neuronal nitric oxide reduces heart rate variability in the anaesthetised dog' Markos, F,Snow, HM,Kidd, C,Conlon, K; (2001) 'Inhibition of neuronal nitric oxide reduces heart rate variability in the anaesthetised dog'. Experimental Physiology, 86 :539-541 [Details]
	(2000)	'Effects of respiratory and metabolic pH changes and hypoxia on ropivacaine-induced cardiotoxicity in dogs' Porter, JM;Markos, F;Snow, HM;Shorten, GD (2000) 'Effects of respiratory and metabolic pH changes and hypoxia on ropivacaine-induced cardiotoxicity in dogs'. British Journal of Anaesthesia, 84 :92-94 [Details]
	(2000)	'The effects of fenoldopam on renal blood flow and tubular function during aortic cross-clamping in anaesthetized dogs' Halpenny, M;Markos, F;Snow, HM;Duggan, PF;Gaffney, E;O'Connell, DP;Shorten, GD (2000) 'The effects of fenoldopam on renal blood flow and tubular function during aortic cross-clamping in anaesthetized dogs'. European Journal of Anaesthesiology, 17 :491-498 [Details]
	(2000)	'Nicorandil, calcium and glyceryl trinitrate - Efficacy in reversal of ropivacaine-induced cardiotoxicity' Porter, J. M.,Markos, F.,Snow, H. M.,Shorten, G. D.; (2000) 'Nicorandil, calcium and glyceryl trinitrate - Efficacy in reversal of ropivacaine-induced cardiotoxicity'. Anesthesiology, 93 (3A3A)   [Details]

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Professional Activities

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Employment

	Employer	Position	From / To
	UCC, Cork	College Lecturer	01-NOV-06 / 01-JUL-10
	TCD	Lecturer	01-JAN-04 / 01-JAN-06
	UCD	Lecturer	01-JAN-02 / 01-JAN-03
	UCC	Post Doc	01-JAN-99 / 01-JAN-02

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Education

	Year	Institution	Qualification	Subject
	1999	UCC, Cork	PHD	*
	1996	UCD, Dublin	B.Sc. (Honours)	*

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Journal Activities

	Journal	Role	To / From
	The Journal Of Physiology	Referee	01-JAN-03 - 01-JAN-08
	Autonomic Neuroscience: Basic & Clinical	Referee	01-JAN-03 - 01-JAN-08
	Experimental Biology And Medicine	Referee	01-JAN-03 - 01-JAN-08
	Physiological Research	Referee	01-JAN-03 - 01-JAN-08

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Teaching Activities

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Teaching Interests

Undergraduate systems Physiology, including the respiratory, digestive, endocrine and reproduction to a variety of students (Physiology, Nursing, Medicine, Dentistry, Pharmacy)