Biography
Having initially qualified as a Nurse I went on to complete a BSc in Physiology and later my PhD. I was appointed as a Lecturer in The Dept of Physiology, UCC in 2003.Research Interests
Physiological research is vital for investigations into a variety of cardiovascular disease states e.g. atherosclerosis and diabetes, both of which are part of UCC's thematic research areas. . We are interested in the physiology and pathophysiology of the vascular glycocalyx. This work, is carried out in collaboration with colleagues in the UK and elsewhere in Ireland. In addition, I have involved in a research project with The School of Pharmacy in UCC, to investigate methods of drug delivery. I have also recently carried out work for the School of Engineering.
Publications
Peer Reviewed Journals
| Year | Publication | |
|---|---|---|
| (2006) | 'Differential inhibition by hyperglycaemia of shear stress- but not acetylcholine-mediated dilatation in the iliac artery of the anaesthetized pig' Kelly R, Ruane-O'Hora T, Noble MI, Drake-Holland AJ, Snow HM ; (2006) 'Differential inhibition by hyperglycaemia of shear stress- but not acetylcholine-mediated dilatation in the iliac artery of the anaesthetized pig'. Journal of Physiology, 573 (pt1):133-145 [Details] | |
| (2011) | 'Effect of clazosentan, a selective endothelin A receptor antagonist, and tezosentan, a dual endothelin A/B antagonist, on pulsatile shear stress induced constriction of the iliac in the anaesthetized pig' Ruane-O'Hora, T,Rae, MG,Markos, F; (2011) 'Effect of clazosentan, a selective endothelin A receptor antagonist, and tezosentan, a dual endothelin A/B antagonist, on pulsatile shear stress induced constriction of the iliac in the anaesthetized pig'. Clinical and Experimental Pharmacology and Physiology, 38 :515-520 [DOI] [Details] | |
| (2011) | 'The effect of alphaxalone-alphadolone, propofol, and pentobarbitone anaesthesia on the beta-endorphin and ACTH response to haemorrhage in the pig' Ruane-O'Hora, T,Hall, WJ,Markos, F; (2011) 'The effect of alphaxalone-alphadolone, propofol, and pentobarbitone anaesthesia on the beta-endorphin and ACTH response to haemorrhage in the pig'. Physiological Research, 89 :521-526 [DOI] [Details] | |
| (2009) | 'The Effect of Ketamine and Saffan on the beta-Endorphin and ACTH Response to Hemorrhage in the Minipig' Ruane-O'Hora, T,Hall, WJ,Markos, F; (2009) 'The Effect of Ketamine and Saffan on the beta-Endorphin and ACTH Response to Hemorrhage in the Minipig'. Physiological Research, 58 :799-805 [Details] | |
| (2013) | 'A novel lipid-based solid dispersion for enhancing oral bioavailability of Lycopene - In vivo evaluation using a pig model' Faisal W, Ruane-O'Hora T, O'Driscoll CM, Griffin BT (2013) 'A novel lipid-based solid dispersion for enhancing oral bioavailability of Lycopene - In vivo evaluation using a pig model'. International Journal of Pharmaceutics, [DOI] [Details] | |
| (2013) | 'Responses of iliac conduit artery and hindlimb resistance vessels to luminal hyperfructosemia in the anaesthetized pig' Ruane-O'Hora, T,Edge, D,Shortt, CM,Markos, F,Noble, MIM (2013) 'Responses of iliac conduit artery and hindlimb resistance vessels to luminal hyperfructosemia in the anaesthetized pig'. Acta Physiologica, 209 :254-261 [DOI] [Details] | |
| (2012) | 'Metformin Causes Nitric Oxide-mediated Dilatation in a Shorter Time Than Insulin in the Iliac Artery of the Anesthetized Pig' O'Hora, TR,Markos, F,Wiernsperger, NF,Noble, MIM (2012) 'Metformin Causes Nitric Oxide-mediated Dilatation in a Shorter Time Than Insulin in the Iliac Artery of the Anesthetized Pig'. Journal of Cardiovascular Pharmacology, 59 :182-187 [DOI] [Details] | |
| (2013) | 'Intraluminal hyperglycaemia causes conduit and resistance artery dilatation and inhibits vascular autoregulation in the anaesthetised pig' 1) Ruane O’Hora T, Shortt CM, Edge D, Markos F, Noble (2013) 'Intraluminal hyperglycaemia causes conduit and resistance artery dilatation and inhibits vascular autoregulation in the anaesthetised pig'. Canadian Journal of Physiology and Pharmacology, [Details] | |
| (2013) | 'What is the mechanism of flow-mediated arterial dilatation' Markos F, Ruane O'Hora T, Noble MI. (2013) 'What is the mechanism of flow-mediated arterial dilatation'. Clinical and experimental pharmacology & physiology, [Details] | |
| (2013) | 'Responses of iliac conduit artery and hindlimb resistance vessels to luminal hyperfructosaemia in the anaesthetized pig' T Ruane O’Hora, D Edge, CM Shortt, F Markos, MIM Noble (2013) 'Responses of iliac conduit artery and hindlimb resistance vessels to luminal hyperfructosaemia in the anaesthetized pig'. Acta Physiologica, [Details] | |
| (2013) | 'A novel lipid-based solid dispersion for enhancing oral bioavailability of Lycopene - In vivo evaluation using a pig model' Faisal, W,Ruane-O'Hora, T,O'Driscoll, CM,Griffin, BT (2013) 'A novel lipid-based solid dispersion for enhancing oral bioavailability of Lycopene - In vivo evaluation using a pig model'. International Journal of Pharmaceutics, 453 :307-314 [DOI] [Details] | |
| (2013) | 'Intraluminal hyperglycaemia causes conduit and resistance artery dilatation and inhibits vascular autoregulation in the anaesthetised pig' Ruane-O'Hora, T,Shortt, CM,Edge, D,Markos, F,Noble, MIM (2013) 'Intraluminal hyperglycaemia causes conduit and resistance artery dilatation and inhibits vascular autoregulation in the anaesthetised pig'. Canadian Journal of Physiology and Pharmacology, 91 :1031-1036 [DOI] [Details] | |
| (2008) | 'Dilatation in the femoral vascular bed does not cause retrograde relaxation of the iliac artery in the anesthetized pig' Markos F, Ruane-O¿Hora T, Snow HM, Kelly R, Wainwright C, Skene K, Drake-Holland AJ, Noble MIM ; (2008) 'Dilatation in the femoral vascular bed does not cause retrograde relaxation of the iliac artery in the anesthetized pig'. Acta Physiologica Scandinavica, [Details] | |
| (2012) | 'Dependence of smooth muscle tone upon pulsatility in the iliac artery of the anaesthetised pig' Markos, F,O'Hora, TR,Wainwright, CL,Noble, MIM (2012) 'Dependence of smooth muscle tone upon pulsatility in the iliac artery of the anaesthetised pig'. Pflugers Archiv-European Journal Of Physiology, 463 :679-684 [DOI] [Details] |
Conference Publications
| Year | Publication | |
|---|---|---|
| (2007) | Royal Academy of Medicine in Ireland, Summer Meeting, Cork Ruane-O¿Hora T, Noble MIM, Kelly R, Drake-Holland AJ & Snow HM. ; (2007) Effect of Hyperglycaemia On The Endothelial Glycocalyx Royal Academy of Medicine in Ireland, Summer Meeting, Cork [Details] |
Manuscript
| Year | Publication | |
|---|---|---|
| (2011) | The responses of the iliac artery to insulin: direct delayed nitric oxide-mediated dilatation. Ruane O¿Hora T, Markos F, Wainwright C, Al-Obaidi M, Noble MIM (2011) The responses of the iliac artery to insulin: direct delayed nitric oxide-mediated dilatation. Manuscript [Details] |
Reviews
| Year | Publication | |
|---|---|---|
| (2013) | What is the mechanism of flow-mediated arterial dilatation. Markos, F,O'Hora, TR,Noble, MIM (2013) What is the mechanism of flow-mediated arterial dilatation. Reviews [DOI] [Details] |
Professional Activities
Professional Associations
| Association | Function | From / To | |
|---|---|---|---|
| An Bord Altranais | Resistered as member | / | |
| The Physiological Society | Member | / |
Conference Contributions
| Year | Publication | |
|---|---|---|
| (2007) | Effect of Hyperglycaemia On The Endothelial Glycocalyx, Ruane-O¿Hora T; (2007) Royal Academy of Medicine in Ireland, Summer meeting, Cork. [Oral Presentation], Effect of Hyperglycaemia On The Endothelial Glycocalyx, Cork , 01-JAN-07 - 31-DEC-07. [Details] |
Employment
| Employer | Position | From / To | |
|---|---|---|---|
| UCC | College Lecturer | 01-NOV-03 / | |
| UCC | Tempory full-time Lecturer (teaching) | 01-OCT-03 / | |
| Ibn Al Bitar Hospital, Baghdad, Iraq | Staff Nurse in Oncology | 01-JAN-87 / 31-DEC-88 |
Education
| Year | Institution | Qualification | Subject | |
|---|---|---|---|---|
| 1992 | UCG | BSC | Physiology | |
| 1998 | UCC | PHD | Physiology | |
| 1986 | Dr. Steevens Hospital, Dublin/An Bord Altranais | RGN | Physiology |
Teaching Activities
Teaching Interests
I have overall responsibility for all aspects of the physiology programme for the BSc Nursing Degree at UCC, involving 400 students accross 2 years of the programme, including organising the physiology contribution to the new curriculum which rolled out in 2012-2013. I had a significant input (in conjunction with an MSc multi-media student) into the design and setting up of a web based multi-media Introductory Physiology Course for mature students. Many of these students do not have a scientific backround and may have been out of a study environment for some time. The course is made available to them a few weeks before the start of formal teaching, and they have unlimited access thereafter.
For 2013-2014 I am taking up the role of Module Coordinator for our BSc research module PL4004. I will also become the overall year coordinator for year 4 for our BSc Physiology degree.
I take part in a variety of activities to promote an awareness of the Dept. of Physiology outside of UCC, including secondary school days, as they arise.
I also lecture on our BSc Physiology degree programme together with lecturing on the Medical, Dental and Pharmacy programmes.
I contribute some teaching to Marymount Hospice as part of their annual programme of continuing education for medical and paramedical staff.
Modules Taught
| Term (ID)) | Title | Link | Subject | |
|---|---|---|---|---|
| 2015 | Research Project | PL4020 | Research Project | |
| 2014 | Research Project | PL4004 | Research Project | |
| 2015 | Introductory Physiology I | PL2021 | Introductory Physiology I | |
| 2015 | Health Needs of People with an Intellectual Disability across the Lifespan III | NU3096 | Health Needs of People with an Intellectual Disability across the Lifespan III | |
| 2015 | Physiology and Pathophysiology of Vascular Endothelium | PL4013 | Physiology and Pathophysiology of Vascular Endothelium |
Contact details
- Therese Ruane-O'Hora
College Lecturer - t.ruane-ohora@ucc.ie
- Physiology
Department of Physiology
University College Cork
Cork - 353 (0)21 4205866
- www.ucc.ie/en/physiology/staff/acad/truaneohara/