Lecturer In Psychiatry
Psychiatry
1.15
Biosciences Institute, University College Cork

E: g.clarke@ucc.ie

Dr Gerard Clarke is a lecturer in the Department of Psychiatry. Gerard graduated with a B.Sc (Hons) in Chemistry from NUI, Galway followed by a M.Sc in Neuropharmacology from the same institution. He subsequently received a Ph.D (Department of Psychiatry) from University College Cork (UCC). Gerard was a visiting scientist in the University of Mississippi Medical Centre in Jackson prior to working for a number of major multi-national pharmaceutical companies in both Ireland and Australia, including Wyeth, Pfizer and 3M. This was followed by periods working as a postdoctoral researcher in the Alimentary Pharmabiotic Centre, as a Research Fellow in the Department of Psychiatry and as a lecturer in the Department of Pharmacology/School of Pharmacy in UCC before taking up his current position as a Lecturer in Psychiatry.


Gerard's current research focus takes a translational approach to the assessment of neurpharmacological indices of stress-related disorders such as depression and irritable bowel syndrome (IBS). This approach incorporates studies in both clinical populations and in animal models using early-life stress templates that produce specific disease phenotypes in adulthood. He is particularly interested in the advancing our understanding of how tryptophan degradation along the kynurenine pathway influences psychopathology and in evaluating novel therapeutic interventions which can reverse such deficits. His research also interrogates the impact of microbiota manipulation on the central nervous system. This is a rapidly expanding area of research with enormous potential and one which is studied using the combined approach of germ-free animals, probiotic administration and antibiotic induced dysbiosis. His research has been recognised internationally by travel awards from the European College of Neuropsychopharmacology (ECNP) as well as a prestigious career development award from the American Neurogastroenterology and Motility Society (ANMS) and a NARSAD award from the Brain and Behaviour Research Foundation. In addition, he is currently a principal investigator on a HRB funded study examining the links between kynurenine pathway metabolites and cognitive dysfunction in IBS and has just recently acquired HRB funding to examine the biological burden of caregiving.

 

Research Interests

Research Interests

  • Neuropharmacological abnormalities in the clinical psychiatry population       
  • Translational biological markers of stress and cognition
  • Brain-gut-microbiome axis dysregulation
  • Tryptophan metabolism

Current Lab Members
Dr Andrew Allen (Postdoctoral Researcher)

Mr Alan Hoban (PhD Student: Co-supervised with Prof John F Cryan)

Ms Katie Togher (PhD Student: Co-supervised with Dr Ali Khashan)

Ms Sarah Dash (External PhD Student: Co-supervised with Prof Felice Jacka)

Ms Jennifer Keyes (MSc Biotech Project Placement)

Previous Lab Members

Dr Paul Kennedy (PhD Student)

Dr Aoife Nolan (Research Assistant)

Dr Cliona O'Mahony (Research Fellow)


Research Support
My research is currently supported by a Health Research Award from the Health Research Board and by a NARSAD Young Investigator Award from the Brain and Behaviour Research Foundation

Research Grants

 ProjectFunding
Body
Start DateEnd DateAward
A Prospective Assessment of the Biological Burden of Stress in Caregivers: Impact on Cognitive Performance, Mood and the Benefits of MindfulnessHealth Research Board01-OCT-1430-SEP-17€329,140.00
Regulation of Anxiety by the Gut Microbiota - Role of Amgdalar and Prefrontal Cortex microRNAs.Foreign Research Institute15-JAN-1414-JAN-16€44,000.00
Kynurenine Pathway Metabolites as Novel Biological Markers of Irritable Bowel Syndrome: A Prospective Study Examining Their Relationship to Gastrointestinal Function, Cognition and Co-morbid DepressionHealth Research Board01-OCT-1130-SEP-14€284,262.50
Kynurenine Pathway Metabolites as a Novel Translational Biological Markers of Irritable Bowel Syndrome.Foreign Research Institute01-JAN-1131-DEC-11€20,842.00
Impact of aerobic exercise on immune parameters and cognition in Multiple SclerosisOther: Not Listed01-JUL-1430-JUN-15

Contract Researchers

Researcher NameProjectRoleFunding Body
Andrew AllenKynurenine Pathway Metabolites as Novel Biological Markers of Irritable Bowel Syndrome: A Prospective Study Examining Their Relationship to Gastrointestinal Function, Cognition and Co-morbid DepressionPostdoctoral ResearcherHealth Research Board

Peer Reviewed Journals

YearPublication
(2015)'Adult hippocampal neurogenesis is regulated by the microbiome'
Ogbonnaya ES, Clarke G, Shanahan F, Dinan TG, Cryan JF, O'Leary OF (2015) 'Adult hippocampal neurogenesis is regulated by the microbiome'. Biological Psychiatry, [Details]
(2014)'Microbiota is essential for social development in the mouse'
Desbonnet, L; Clarke, G; Shanahan, F; Dinan, TG; Cryan, JF (2014) 'Microbiota is essential for social development in the mouse'. Molecular Psychiatry, [DOI] [Details]
(2014)'Microbiota and neurodevelopmental windows: implications for brain disorders'
Borre, Y. E.,O'Keeffe, G. W.,Clarke, G.,Stanton, C.,Dinan, T. G.,Cryan, J. F. (2014) 'Microbiota and neurodevelopmental windows: implications for brain disorders'. Trends Mol Med, 20 (99):509-518 Globe icon [Details]
(2014)'Priming for health: gut microbiota acquired in early life regulates physiology, brain and behaviour'
Clarke, G.,O'Mahony, S. M.,Dinan, T. G.,Cryan, J. F. (2014) 'Priming for health: gut microbiota acquired in early life regulates physiology, brain and behaviour'. Acta Paediatracta Paediatr, 103 (88):812-9 Globe icon [Details]
(2014)'Serotonin, tryptophan metabolism and the brain-gut-microbiome axis'
O'Mahony, S. M.,Clarke, G.,Borre, Y. E.,Dinan, T. G.,Cryan, J. F. (2014) 'Serotonin, tryptophan metabolism and the brain-gut-microbiome axis'. Behav Brain Resbehav Brain Res, Globe icon [Details]
(2014)'A sustained hypothalamic-pituitary-adrenal axis response to acute psychosocial stress in irritable bowel syndrome'
Kennedy, P. J.,Cryan, J. F.,Quigley, E. M.,Dinan, T. G.,Clarke, G. (2014) 'A sustained hypothalamic-pituitary-adrenal axis response to acute psychosocial stress in irritable bowel syndrome'. Psychol Med, 44 (1414):3123-34 Globe icon [Details]
(2014)'Biological and psychological markers of stress in humans: focus on the Trier Social Stress Test'
Allen, A. P.,Kennedy, P. J.,Cryan, J. F.,Dinan, T. G.,Clarke, G. (2014) 'Biological and psychological markers of stress in humans: focus on the Trier Social Stress Test'. Neurosci Biobehav Rev, 38 :94-124 Globe icon [Details]
(2014)'The microbiome: stress, health and disease'
Moloney, R. D.,Desbonnet, L.,Clarke, G.,Dinan, T. G.,Cryan, J. F. (2014) 'The microbiome: stress, health and disease'. Mamm Genome, 25 (1-21-2):49-74 Globe icon [Details]
(2014)'Minireview: gut microbiota: the neglected endocrine organ'
Clarke, G.,Stilling, R. M.,Kennedy, P. J.,Stanton, C.,Cryan, J. F.,Dinan, T. G. (2014) 'Minireview: gut microbiota: the neglected endocrine organ'. Mol Endocrinol, 28 (88):1221-38 Globe icon [Details]
(2014)'Cognitive performance in irritable bowel syndrome: evidence of a stress-related impairment in visuospatial memory'
Kennedy, P. J.,Clarke, G.,O'Neill, A.,Groeger, J. A.,Quigley, E. M.,Shanahan, F.,Cryan, J. F.,Dinan, T. G. (2014) 'Cognitive performance in irritable bowel syndrome: evidence of a stress-related impairment in visuospatial memory'. Psychol Med, 44 (77):1553-66 Globe icon [Details]
(2014)'A prospective study of C-reactive protein as a state marker in Cardiac Syndrome X'
Dollard, J.,Kearney, P.,Clarke, G.,Moloney, G.,Cryan, J. F.,Dinan, T. G. (2014) 'A prospective study of C-reactive protein as a state marker in Cardiac Syndrome X'. Brain Behav Immun, Globe icon [Details]
(2014)'Effect of Acute Swim Stress on Plasma Corticosterone and Brain Monoamine Levels in Bidirectionally Selected DxH Recombinant Inbred Mouse Strains Differing in Fear Recall and Extinction'
5. Browne CA, Hanke J, Rose C, Walsh I, Foley T, Clarke G, Schwegler H, Cryan JF, Yilmazer-Hanke D. (2014) 'Effect of Acute Swim Stress on Plasma Corticosterone and Brain Monoamine Levels in Bidirectionally Selected DxH Recombinant Inbred Mouse Strains Differing in Fear Recall and Extinction'. Stress (Amsterdam, Netherlands), [Details]
(2014)'The P-glycoprotein inhibitor cyclosporin A differentially influences behavioural and neurochemical responses to the antidepressant escitalopram'
O'Brien, FE,O'Connor, RM,Clarke, G,Donovan, MD,Dinan, TG,Griffin, BT,Cryan, JF (2014) 'The P-glycoprotein inhibitor cyclosporin A differentially influences behavioural and neurochemical responses to the antidepressant escitalopram'. Behavioural Brain Research, 261 :17-25 [DOI] [Details]
(2014)'Long-lasting glutamatergic modulation induced by neonatal GABA enhancement in mice'
Melamed, O,Levav-Rabkin, T,Zukerman, C,Clarke, G,Cryan, JF,Dinan, TG,Grossman, Y,Golan, HM (2014) 'Long-lasting glutamatergic modulation induced by neonatal GABA enhancement in mice'. Neuropharmacology, 79 :616-625 [DOI] [Details]
(2014)'A review of ketamine in affective disorders: Current evidence of clinical efficacy, limitations of use and pre-clinical evidence on proposed mechanisms of action'
Naughton M, Clarke G, O'Leary OF, Cryan JF, Dinan TG (2014) 'A review of ketamine in affective disorders: Current evidence of clinical efficacy, limitations of use and pre-clinical evidence on proposed mechanisms of action'. Journal of Affective Disorders, 156 :24-35 [Details]
(2014)'Milk protein-derived peptides induce 5-HT2C-mediated satiety,in vivo'
Schellekens, H,Nongonierma, AB,Clarke, G,van Oeffelen, WEPA,FitzGerald, RJ,Dinan, TG,Cryan, JF (2014) 'Milk protein-derived peptides induce 5-HT2C-mediated satiety,in vivo'. International Dairy Journal, 38 :55-64 [DOI] [Details]
(2014)'The impact of microbiota on brain and behavior: mechanisms & therapeutic potential'
Borre, Y. E.,Moloney, R. D.,Clarke, G.,Dinan, T. G.,Cryan, J. F. (2014) 'The impact of microbiota on brain and behavior: mechanisms & therapeutic potential'. Adv Exp Med Biol, 817 :373-403 Globe icon [Details]
(2013)'The Microbiome-Gut-Brain Axis During Early-Life Regulates the Hippocampal Serotonergic System in a Sex-Dependent Manner'
Clarke, G; Grenham, S; Scully, P; Fitzgerald, P; Moloney, R; Shanahan, F; Dinan, T; Cryan, J (2013) 'The Microbiome-Gut-Brain Axis During Early-Life Regulates the Hippocampal Serotonergic System in a Sex-Dependent Manner'. Molecular Psychiatry, 18 (6):666-673 [Details]
(2013)'Alterations in prefrontal cortical serotonin and antidepressant-like behavior in a novel C3H/HeJxDBA/2J recombinant inbred mouse strain'
Browne CA; Clarke G; Hanke J; Dinan TG; Schwegler H; Yilmazer-Hanke DM; Cryan JF (2013) 'Alterations in prefrontal cortical serotonin and antidepressant-like behavior in a novel C3H/HeJxDBA/2J recombinant inbred mouse strain'. Behavioral Brain Research, [Details]
(2013)'Differential visceral nociceptive, behavioural and neurochemical responses to an immune challenge in the stress-sensitive Wistar Kyoto rat strain'
Mahony, SMO,Clarke, G,McKernan, DP,Bravo, JA,Dinan, TG,Cryan, JF (2013) 'Differential visceral nociceptive, behavioural and neurochemical responses to an immune challenge in the stress-sensitive Wistar Kyoto rat strain'. Behavioural Brain Research, 253 :310-317 [DOI] [Details]
(2013)'P-glycoprotein Inhibition Increases the Brain Distribution and Antidepressant-Like Activity of Escitalopram in Rodents'
O'Brien, FE,O'Connor, RM,Clarke, G,Dinan, TG,Griffin, BT,Cryan, JF (2013) 'P-glycoprotein Inhibition Increases the Brain Distribution and Antidepressant-Like Activity of Escitalopram in Rodents'. Neuropsychopharmacology, 38 :2209-2219 [DOI] [Details]
(2013)'Human P-glycoprotein differentially affects antidepressant drug transport: relevance to blood-brain barrier permeability'
O'Brien, FE,Clarke, G,Dinan, TG,Cryan, JF,Griffin, BT (2013) 'Human P-glycoprotein differentially affects antidepressant drug transport: relevance to blood-brain barrier permeability'. International Journal of Neuropsychopharmacology, 16 :2259-2272 [DOI] [Details]
(2012)'An effective dietary method for chronic tryptophan depletion in two mouse strains illuminates a role for 5-HT in nesting behaviour'
Browne, CA,Clarke, G,Dinan, TG,Cryan, JF (2012) 'An effective dietary method for chronic tryptophan depletion in two mouse strains illuminates a role for 5-HT in nesting behaviour'. Neuropharmacology, 62 :1903-1915 [DOI] [Details]
(2012)'Menstrual Cycle Influences Toll-Like Receptor Responses'
Dennison, U,McKernan, DP,Scully, P,Clarke, G,Cryan, J,Dinan, T (2012) 'Menstrual Cycle Influences Toll-Like Receptor Responses'. Neuroimmunomodulation, 19 :171-179 [DOI] [Details]
(2012)'Phenotypic effects of repeated psychosocial stress during adolescence in mice mutant for the schizophrenia risk gene neuregulin-1: A putative model of gene x environment interaction'
Desbonnet, L,O'Tuathaigh, C,Clarke, G,O'Leary, C,Petit, E,Clarke, N,Tighe, O,Lai, D,Harvey, R,Cryan, JF,Dinan, TG,Waddington, JL (2012) 'Phenotypic effects of repeated psychosocial stress during adolescence in mice mutant for the schizophrenia risk gene neuregulin-1: A putative model of gene x environment interaction'. Brain Behav Immun, 26 :660-671 [DOI] [Details]
(2012)'A Distinct Profile of Tryptophan Metabolism along the Kynurenine Pathway Downstream of Toll-Like Receptor Activation in Irritable Bowel Syndrome'
Clarke, G; McKernan, D; Gaszner, G; Quigley, E; Cryan, J; Dinan, T (2012) 'A Distinct Profile of Tryptophan Metabolism along the Kynurenine Pathway Downstream of Toll-Like Receptor Activation in Irritable Bowel Syndrome'. Frontiers In Pharmacology, 3:90 [DOI] [Details]
(2012)'Gut memories: towards a cognitive neurobiology of irritable bowel syndrome'
Kennedy PJ, Clarke G, Quigley EM, Groeger JA, Dinan TG, Cryan JF (2012) 'Gut memories: towards a cognitive neurobiology of irritable bowel syndrome'. Neuroscience and Biobehavioral Reviews, 36 (1):310-340 [DOI] [Details]
(2012)'Inhibition of P-glycoprotein Enhances Transport of the Antidepressant Imipramine across the Blood-Brain Barrier: Microdialysis Studies in the Conscious Freely Moving Rat'
O'Brien FE, Clarke G, Fitzgerald P, Dinan TG, Griffin BT, Cryan JF (2012) 'Inhibition of P-glycoprotein Enhances Transport of the Antidepressant Imipramine across the Blood-Brain Barrier: Microdialysis Studies in the Conscious Freely Moving Rat'. British Journal of Pharmacology, [DOI] [Details]
(2012)'Dynamic 5-HT(2C) Receptor Editing in a Mouse Model of Obesity'
Schellekens H, Clarke G, Jeffery IB, Dinan TG, Cryan JF (2012) 'Dynamic 5-HT(2C) Receptor Editing in a Mouse Model of Obesity'. Plos One, 7 (3) [DOI] [CORA Link] [Details]
(2012)'Review article: probiotics for the treatment of irritable bowel syndrome - focus on lactic acid bacteria'
Clarke G, Cryan JF, Dinan TG, Quigley EM (2012) 'Review article: probiotics for the treatment of irritable bowel syndrome - focus on lactic acid bacteria'. Alimentary Pharmacology And Therapeutics, 35 (4):403-413 [DOI] [Details]
(2012)'Chronic stress-induced alterations in mouse colonic 5-HT and defecation responses are strain dependent'
Julio-Pieper M, O'Mahony CM, Clarke G, Bravo JA, Dinan TG, Cryan JF (2012) 'Chronic stress-induced alterations in mouse colonic 5-HT and defecation responses are strain dependent'. Stress (Amsterdam, Netherlands), [DOI] [Details]
(2011)'Brain-gut-microbe communication in health and disease'
Grenham S, Clarke G, Cryan JF, Dinan TG (2011) 'Brain-gut-microbe communication in health and disease'. Frontiers in Physiology, 2 [DOI] [Details]
(2011)'Genetic vs. pharmacological inactivation of COMT influences cannabinoid-induced expression of schizophrenia-related phenotypes'
O'Tuathaigh CM, Clarke G, Walsh J, Desbonnet L, Petit E, O'Leary C, Tighe O, Clarke N, Karayiorgou M, Gogos JA, Dinan TG, Cryan JF, Waddington JL (2011) 'Genetic vs. pharmacological inactivation of COMT influences cannabinoid-induced expression of schizophrenia-related phenotypes'. International Journal of Neuropsychopharmacology, :1-12 [DOI] [Details]
(2011)'Differential stress-induced alterations in tryptophan hydroxylase activity and serotonin turnover in two inbred mouse strains'
Browne CA, Clarke G, Dinan TG, Cryan JF; (2011) 'Differential stress-induced alterations in tryptophan hydroxylase activity and serotonin turnover in two inbred mouse strains'. Neuropharmacology, 60 (4):683-691 [DOI] [Details]
(2010)'Marked elevations in pro-inflammatory polyunsaturated fatty acid metabolites in females with irritable bowel syndrome'
Clarke, G; Fitzgerald, P; Hennessy, AA; Cassidy, EM; Quigley, EMM; Ross, P; Stanton, C; Cryan, JF; Dinan, TG; (2010) 'Marked elevations in pro-inflammatory polyunsaturated fatty acid metabolites in females with irritable bowel syndrome'. Journal of Lipid Research, 51 :1186-1192 [DOI] [Details]
(2010)'Effects of the probiotic Bifidobacterium infantis in the maternal separation model of depression'
Desbonnet L, Garrett L, Clarke G, Kiely B, Cryan JF, Dinan TG; (2010) 'Effects of the probiotic Bifidobacterium infantis in the maternal separation model of depression'. Neuroscience, 170 (4):1179-1188 [DOI] [Details]
(2010)'Strain differences in the neurochemical response to chronic restraint stress in the rat: Relevance to depression'
O'Mahony CM, Clarke G, Gibney S, Dinan TG, Cryan JF; (2010) 'Strain differences in the neurochemical response to chronic restraint stress in the rat: Relevance to depression'. Pharmacology Biochemistry and Behavior, [DOI] [Details]
(2010)'A Sensitive Period of Mice Inhibitory System to Neonatal GABA Enhancement by Vigabatrin is Brain Region Dependent'
Levav-Rabkin, T; Melamed, O; Clarke, G; Farber, M; Cryan, JF; Dinan, TG; Grossman, Y; Golan, HM; (2010) 'A Sensitive Period of Mice Inhibitory System to Neonatal GABA Enhancement by Vigabatrin is Brain Region Dependent'. Neuropsychopharmacology, 35 :1138-1154 [DOI] [Details]
(2009)'Chain reactions: early-life stress alters the metabolic profile of plasma polyunsaturated fatty acids in adulthood'
Clarke, G; O'Mahony, SM; Hennessy, AA; Ross, P; Stanton, C; Cryan, JF; Dinan, TG; (2009) 'Chain reactions: early-life stress alters the metabolic profile of plasma polyunsaturated fatty acids in adulthood'. Behavioural Brain Research, 205 (1):319-321 [DOI] [Details]
(2008)'Enhanced Cholinergic-Mediated Increase in the Pro-Inflammatory Cytokine IL-6 in Irritable Bowel Syndrome: Role of Muscarinic Receptors'
Dinan, TG,Clarke, G,Quigley, EMM,Scott, LV,Shanahan, F,Cryan, J,Cooney, J,Keeling, PWN; (2008) 'Enhanced Cholinergic-Mediated Increase in the Pro-Inflammatory Cytokine IL-6 in Irritable Bowel Syndrome: Role of Muscarinic Receptors'. American Journal of Gastroenterology, 103 :2570-2576 [DOI] [Details]
(2009)'Irritable bowel syndrome: towards biomarker identification'
Clarke, G; Quigley, EM; Cryan, JF; Dinan, TG; (2009) 'Irritable bowel syndrome: towards biomarker identification'. Trends In Molecular Medicine, 15 (10):478-489 [DOI] [Details]
(2009)'Antagonist but not agonist labeling of serotonin-1A receptors is decreased in major depressive disorder'
Stockmeier CA, Howley E, Shi X, Sobanska A, Clarke G, Friedman L, Rajkowska G (2009) 'Antagonist but not agonist labeling of serotonin-1A receptors is decreased in major depressive disorder'. Journal of Psychiatric Research, 43 (10):887-894 [DOI] [Details]
(2009)'Tryptophan degradation in irritable bowel syndrome: evidence of indoleamine 2,3-dioxygenase activation in a male cohort'
Clarke G, Fitzgerald P, Cryan JF, Cassidy EM, Quigley EM, Dinan TG; (2009) 'Tryptophan degradation in irritable bowel syndrome: evidence of indoleamine 2,3-dioxygenase activation in a male cohort'. BMC Gastroenterology, 9 [DOI] [Details]
(2009)'A serologic test for irritable bowel syndrome: real meat or bare bones?'
Quigley EM, Clarke G (2009) 'A serologic test for irritable bowel syndrome: real meat or bare bones?'. Gastroenterology, 137 (6):2168-2170 [DOI] [Details]
(2009)'Verapamil In Treatment Resistant Depression: A Role For The P-Glycoprotein Transporter?'
Clarke, G, O'Mahony, SM, Cryan, JF, Dinan, TG; (2009) 'Verapamil In Treatment Resistant Depression: A Role For The P-Glycoprotein Transporter?'. Human Psychopharmacology-Clinical and Experimental, 24 (3):217-223 [DOI] [Details]
(2009)'Kynurenine Pathway In Psychosis: Evidence of Increased Tryptophan Degradation'
Barry, S, Clarke, G, Scully, P, Dinan, TG; (2009) 'Kynurenine Pathway In Psychosis: Evidence of Increased Tryptophan Degradation'. Journal of Psychopharmacology, 23 (3):287-294 [DOI] [Details]
(2008)'The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat'
Desbonnet L, Garrett L, Clarke G, Bienenstock J, Dinan TG (2008) 'The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat'. Journal of Psychiatric Research, 43 (2):164-174 [DOI] [Details]
(2008)'Tryptophan catabolism in females with irritable bowel syndrome: relationship to interferon-gamma, severity of symptoms and psychiatric co-morbidity'
Fitzgerald, P.,Eugene, M. C.,Clarke, G.,Scully, P.,Barry, S.,Eamonn, M. M. Q.,Shanahan, F.,Cryan, J.,Timothy, G. D. (2008) 'Tryptophan catabolism in females with irritable bowel syndrome: relationship to interferon-gamma, severity of symptoms and psychiatric co-morbidity'. Neurogastroenterology and Motility, 20 (1212):1291-12971291 Globe icon [Details]
(2008)'Evidence of an enhanced central 5HT response in irritable bowel syndrome and in the rat maternal separation model'
O'Mahony, S.,Chua, A. S. B.,Quigley, E. M. M.,Clarke, G.,Shanahan, F.,Keeling, P. W. N.,Dinan, T. G. (2008) 'Evidence of an enhanced central 5HT response in irritable bowel syndrome and in the rat maternal separation model'. Neurogastroenterology and Motility, 20 (66):680-688680 Globe icon [Details]
(2007)'An Isocratic High Performance Liquid Chromatography Method For The Determination of Gaba and Glutamate In Discrete Regions of The Rodent Brain'
Clarke, G, Mahony, S, Malone, G, Dinan, TG; (2007) 'An Isocratic High Performance Liquid Chromatography Method For The Determination of Gaba and Glutamate In Discrete Regions of The Rodent Brain'. Journal of Neuroscience Methods, 160 (2):223-230 [DOI] [Details]

Book Chapters

YearPublication
(2014)'The impact of microbiota on brain and behavior: mechanisms & therapeutic potential'
Borre YE, Moloney RD, Clarke G, Dinan TG, Cryan JF. (2014) 'The impact of microbiota on brain and behavior: mechanisms & therapeutic potential' In: Microbial Endocrinology. New York: Springer. [Details]
(2014)'Characterising the Gut Microbiome: Role in Brain–Gut Function'
Clarke G, O'Toole P, Cryan JF, Dinan TG (2014) 'Characterising the Gut Microbiome: Role in Brain–Gut Function' In: The Omics:Applications in Neuroscience. New York: Oxford University Press. [Details]
(2013)'The Brain-Gut Axis: A Target for Treating Stress-Related Disorders'
Scott, L; Clarke, G; Dinan, TG (2013) 'The Brain-Gut Axis: A Target for Treating Stress-Related Disorders' In: Inflammation in Psychiatry. Basel: Karger. [Details]

Conference Publications

YearPublication
(2014)Society for Neuroscience (SFN) Neuroscience 2014, November 15-19, Washington, USA
Kennedy PJ, Allen AP, O’Neill A, Quigley EMM, Cryan JF, Dinan TG and Clarke G (2014) Acute tryptophan depletion modulates kynurenine production: Implications for treatment of cognitive impairment in brain-gut axis disorders Society for Neuroscience (SFN) Neuroscience 2014, November 15-19, Washington, USA , 15-NOV-14 - 19-NOV-14 [Details]
(2014)Society for Neuroscience (SFN) Neuroscience 2014, Washington, USA
Clarke G, Naughton M, O’Shea R, Dowling J, Walsh A, Ismail F, Shorten G, Scott L, Cryan JF, Dinan TG. (2014) Rapid antidepressant response to ketamine in treatment-resistant depression is not dependent on normalising kynurenine pathway metabolism Society for Neuroscience (SFN) Neuroscience 2014, Washington, USA Washington, , 15-NOV-14 - 19-NOV-14 [Details]
(2014)Society for Neuroscience (SFN) Neuroscience 2014, November 15-19, Washington, USA
Allen AP, Naughton M, Clarke G, O’Shea R, Dowling J, Walsh A, Ismail F, Shorten G, Scott L, Cryan JF, Dinan TG (2014) A delayed brain-derived neurotrophic factor response to ketamine infusion: Implications for rapid symptom improvements in treatment-resistant depression Society for Neuroscience (SFN) Neuroscience 2014, November 15-19, Washington, USA , 15-NOV-14 - 19-NOV-14 [Details]
(2014)Society for Neuroscience (SFN) Neuroscience 2014, November 15-19, Washington, USA
Borre YE, Hecke Morais L, Golubeva AV, Patterson E, Crispie F, Moloney RD, Scott KA, Stilling R, Hyland NP, Clarke G, Stanton C, Cotter PD, Dinan TG, Cryan JF. (2014) Mode of delivery at birth and behavioural outcomes: Rewiring of the brain-gut-microbiome axis? Society for Neuroscience (SFN) Neuroscience 2014, November 15-19, Washington, USA , 15-NOV-14 - 19-NOV-14 [Details]
(2014)Society for Neuroscience (SFN) Neuroscience 2014, November 15-19, Washington, USA
Moloney G, O' Leary O, Desbonnet L, Shanahan F, Dinan TG, Clarke G, Cryan JF (2014) Microbiota regulates microRNA expression in the hippocampus in a sex dependent manner Society for Neuroscience (SFN) Neuroscience 2014, November 15-19, Washington, USA , 15-NOV-14 - 19-NOV-14 [Details]
(2014)Society for Neuroscience (SFN) Neuroscience 2014, November 15-19, Washington, USA
Scott KA, Moloney G, Naughton M, O'Connor RM, Mcloughlin DM, Dowling J, Shorten G, Walsh A, Scott L, Ismail F, Clarke G, Dinan TG, Cryan JF (2014) Whole blood microRNAs as biomarkers of treatment-resistant depression? Effects of ketamine and electroconvulsive therapy Society for Neuroscience (SFN) Neuroscience 2014, November 15-19, Washington, USA , 15-NOV-14 - 19-NOV-14 [Details]
(2014)27th European College of Neuropsychopharmacology Congress (ECNP), 18th-21st October 2014, Berlin, Germany
Kennedy PJ, Allen AP, O’Neill A, Quigley EMM, Cryan JF, Dinan TG and Clarke G (2014) Acute Typtophan depletion modulates Kynurenine production: A challenging component of cognitive impairment in brain-gut axis disorders 27th European College of Neuropsychopharmacology Congress (ECNP), 18th-21st October 2014, Berlin, Germany , 19-OCT-14 - 21-OCT-14 [Details]
(2014)27th European College of Neuropsychopharmacology Congress (ECNP), 18th-21st October 2014, Berlin, Germany
Clarke G, Naughton M, O’Shea R, Dowling J, Walsh A, Ismail F, Shorten G, Scott L, Cryan JF, Dinan TG. (2014) Biological Markers of the Rapid Antidepressant Response to Ketamine in Treatment-resistant Depression: Focus on the Kynurenine Pathway of Tryptophan Metabolism 27th European College of Neuropsychopharmacology Congress (ECNP), 18th-21st October 2014, Berlin, Germany , 18-OCT-14 - 21-OCT-14 [Details]
(2014)27th European College of Neuropsychopharmacology Congress (ECNP), 18th-21st October 2014, Berlin, Germany
Allen AP, Naughton M, Clarke G, O’Shea R, Dowling J, Walsh A, Ismail F, Shorten G, Scott L, Cryan JF, Dinan TG (2014) Serum brain-derived neurotrophic factor and symptom improvements post-ketamine treatment in treatment-resistant depression 27th European College of Neuropsychopharmacology Congress (ECNP), 18th-21st October 2014, Berlin, Germany , 18-OCT-14 - 21-OCT-14 [Details]
(2014)27th European College of Neuropsychopharmacology Congress (ECNP), 19th-21st October 2014, Berlin, Germany
Naughton M, Allen AP, Clarke G, O’Shea R, Dowling J, Walsh A, Ismail F, Shorten G, Scott L, Cryan JF, Dinan TG. (2014) The cortisol awakening response in treatment-resistant depression is not a biomarker of the clinical response to ketamine 27th European College of Neuropsychopharmacology Congress (ECNP), 19th-21st October 2014, Berlin, Germany , 18-OCT-14 - 21-OCT-14 [Details]
(2014)Young Neuroscientists Symposium (YNS) 2014 20th September 2014, Trinity Biomedical Sciences Institute, Trinity College Dublin
Naughton M, Allen AP, Clarke G, Dowling J, Walsh A, Ismail F, Shorten G, Scott L, Cryan JF, Dinan TG. (2014) Biomarkers of ketamine efficacy in treatment-resistant depression: Focus on BDNF Young Neuroscientists Symposium (YNS) 2014 20th September 2014, Trinity Biomedical Sciences Institute, Trinity College Dublin , 20-SEP-14 - 20-SEP-14 [Details]
(2014)Young Neuroscientists Symposium (YNS) 2014 20th September 2014, Trinity Biomedical Sciences Institute, Trinity College Dublin
Hoban AE, Stilling RM, Desbonnet L, Shanahan F, Dinan TG, Cryan JF, Clarke, G (2014) Regulation of microRNAs in the Amygdala by the Gut Microbiota: Implications for Brain and Behaviour Young Neuroscientists Symposium (YNS) 2014 20th September 2014, Trinity Biomedical Sciences Institute, Trinity College Dublin , 20-SEP-14 - 20-SEP-14 [Details]
(2014)International College of Neuropsychopharmacology (CINP) 29th World Congress Vancouver 22 – 26 June 2014
Kennedy PJ, Allen AP, O’Neill A, Quigley EMM, Cryan JF, Dinan TG and Clarke G (2014) Kynurenine production is reduced by acute typtophan depletion: Implications for cognitive impairment in brain-gut axis disorders International College of Neuropsychopharmacology (CINP) 29th World Congress Vancouver 22 – 26 June 2014 , 22-JUN-14 - 26-JUN-14 [Details]
(2014)Digestive Disease Week (DDW) Chicago May 2014
Kennedy PJ, Allen AP, O’Neill A, Quigley EMM, Cryan JF, Dinan TG and Clarke G (2014) Acute Tryptophan Depletion Reduces Kynurenine Levels: Implications for Treatment of Impaired Visuospatial Memory Performance in Irritable Bowel Syndrome Digestive Disease Week (DDW) Chicago May 2014 [Details]
(2014)Digestive Disease Week (DDW) Chicago May 2014
Arijs I, Wollants WJ, Clarke G, Persoons P, Van Lommel L, Machiels K, Ferrante M, Schuit F, Vermeire S, Rutgeerts P (2014) The effect of infliximab therapy on the tryptophan metabolism and indoleamine 2,3-dioxygenase expression (IDO) in patients with inflammatory bowel disease Digestive Disease Week (DDW) Chicago May 2014 [Details]
(2014)2014 Pediatric Academic Societies and Asian Society for Pediatric Research Joint Meeting in Vancouver, BC, Canada, May 3-6
O’Rourke L, Clarke G, Nolan A, Dinan TG, Stanton C, Ryan CA (2014) The Relationship Between Maternal Tryptophan Metabolism, Cytokines and Cortisol in Term and Preterm Expressed Breast Milk 2014 Pediatric Academic Societies and Asian Society for Pediatric Research Joint Meeting in Vancouver, BC, Canada, May 3-6 , 03-MAY-14 - 06-MAY-14 [Details]
(2014)ECNP Workshop for Junior Scientists in Europe, 6-9 March 2014, Nice, France
Kennedy PJ, Allen AP, O’Neill A, Quigley EMM, Cryan JF, Dinan TG and Clarke G (2014) Acute Typtophan depletion modulates Kynurenine production: A challenging component of cognitive impairment in brain-gut axis disorders ECNP Workshop for Junior Scientists in Europe, 6-9 March 2014, Nice, France , 06-MAR-14 - 09-MAR-14 [Details]
(2013)3rd Annual UK & Ireland Early Career BBB Symposium, Cambridge, UK, 22 November 2013
O’Brien FE, Clarke G, Dinan TG, Griffin BT, Cryan JF. (2013) P-glycoprotein inhibition as a strategy to augment antidepressant delivery across the blood-brain barrier: preclinical pharmacokinetic and pharmacodynamic studies 3rd Annual UK & Ireland Early Career BBB Symposium, Cambridge, UK, 22 November 2013 [Details]
(2013)Irish Paediatric Association Annual Meeting, Dublin, Ireland 8-9th November 2013
O’Rourke L, Clarke G, Nolan A, Dinan TG, Stanton C, Ryan CA (2013) Tryptophan and its kynurenine pathway metabolites in breastmilk. Influence of maternal stress and immune status and developmental relevance Irish Paediatric Association Annual Meeting, Dublin, Ireland 8-9th November 2013 , 08-NOV-13 - 09-NOV-13 [Details]
(2013)United European Gastroenterology Week, Berlin, Germany, October 2013
Kennedy PJ, Clarke G, Allen AP, Ann O’Neill A, Groeger JA, Quigley EM, Shanahan F , Cryan JF, Dinan TG (2013) A prospective study of cognitive performance in irritable bowel syndrome: visuospatial memory deficits as a stable feature United European Gastroenterology Week, Berlin, Germany, October 2013 [Details]
(2013)Neuroscience Ireland, Cork, Ireland September 2013
Kennedy PJ, Allen AP, O’Neill A, Quigley EMM, Cryan JF, Dinan TG, Clarke G (2013) A role for the kynurenine pathway in neuropsychological performance following acute tryptophan depletion? Neuroscience Ireland, Cork, Ireland September 2013 [Details]
(2013)Neuroscience Ireland, Cork, Ireland September 2013
Desbonnet L, Clarke G, Shanahan F, Dinan TG, Cryan JF (2013) Microbiota is essential for social development in the mouse Neuroscience Ireland, Cork, Ireland September 2013 [Details]
(2013)International Society of Psychoneuroendocrinology (ISPNE), Leiden, Netherlands, August 2013
Kennedy P, Clarke G, Groeger J, Quigley EMM, Cryan JF, Dinan TG (2013) Sustained Hypothalamic-Pituitary-Adrenal-Axis Response to Acute Psychosocial Stress in Irritable Bowel Syndrome International Society of Psychoneuroendocrinology (ISPNE), Leiden, Netherlands, August 2013 [Details]
(2013)Digestive Disease Week, Florida, USA, May 2013
Kennedy PJ, Clarke G, Allen AP, Ann O’Neill A, Groeger JA, Quigley EM, Shanahan F , Cryan JF, Dinan TG (2013) A Prospective Assessment of Cognitive Performance in Irritable Bowel Syndrome Reveals Persistent Visuospatial Memory Deficits Digestive Disease Week, Florida, USA, May 2013 [Details]
(2013)International Behavioural Neuroscience Society, Dublin, June 2013
Kennedy PJ, O’Mahony, Clarke G, Dinan TG, Cryan JF (2013) Impaired contextual fear extinction and novel object recognition memory in a chronic psychosocial stress mouse model of brain-gut axis dysfunction International Behavioural Neuroscience Society, Dublin, June 2013 [Details]
(2013)European Society for Paediatric Research, Porto, Portugal, October 2013
Looney AM, Walsh BH, Grenham S, Moloney G, Clarke G, Cryan JF, Dinan TG, Boylan GB, Murray DM (2013) The expression profile of miRNA in the umbilical cord blood of infants with hypoxic ischaemic encephalopathy; potential biomarkers of injury European Society for Paediatric Research, Porto, Portugal, October 2013 [Details]
(2013)British and Irish Gastroenterology (BIG) Spring Meeting, Belfast, April 2013
Kennedy PJ, Clarke G, Allen AP, Ann O’Neill A, Groeger JA, Quigley EM, Shanahan F , Cryan JF, Dinan TG. (2013) A Prospective Study of Cognitive Performance in Irritable Bowel Syndrome: Visuospatial Memory Deficits as a Stable Feature British and Irish Gastroenterology (BIG) Spring Meeting, Belfast, April 2013 [Details]
(2013)Royal Academy of Medicine in Ireland (RAMI) Annual Meeting, University College Cork, June 2013
Ogbonnaya S, Clarke G, Shanahan FS, Cryan JF, O’Leary OF (2013) Establishment of the gut microbiome during early life influences the survival of newly-born cells in the adult hippocampus Royal Academy of Medicine in Ireland (RAMI) Annual Meeting, University College Cork, June 2013 [Details]
(2013)Royal Academy of Medicine in Ireland (RAMI) Annual Meeting, University College Cork, June 2013
O’Brien FE, O’Connor RM, Clarke G, Dinan TG, Griffin BT, Cryan JF (2013) Effect of P-glycoprotein Inhibition on the brain distribution and antidepressant-like activity of escitalopram in rodents Royal Academy of Medicine in Ireland (RAMI) Annual Meeting, University College Cork, June 2013 [Details]
(2013)International Behavioural Neuroscience Society Annual Meeting, Dublin, 25th -30th June 2013
Ogbonnaya S., Clarke G., Shanahan, F., Dinan T.G., Cryan, J. F., O’Leary, O.F. (2013) The microbiome-gut-brain axis regulates the survival of newly-born cells in the adult hippocampus International Behavioural Neuroscience Society Annual Meeting, Dublin, 25th -30th June 2013 [Details]
(2012)Neurogastroenterology and Motility, Bologna, Italy, September 2012
Clarke G, Grenham S, Scully P, Fitzgerald P, Shanahan F, Dinan TG, Cryan JF (2012) The Microbiome-Gut-Brain Axis as a Regulator of Serotonergic Neurotransmission and Behaviour Neurogastroenterology and Motility, Bologna, Italy, September 2012 [Details]
(2012)Neuroscience Ireland, RCSI, Dublin, September 2012
O’Brien FE, Clarke G, Dinan TG, Cryan JF, Griffin BT (2012) P-glycoprotein restricts blood-brain barrier transport of the antidepressant escitalopram: converging evidence from in vitro and in vivo studies Neuroscience Ireland, RCSI, Dublin, September 2012 [Details]
(2012)British Pharmacological Society (BPS) Winter Meeting, London, December 2012
O’Brien FE, Clarke G, Dinan TG, Cryan JF, Griffin BT (2012) The Influence of P-glycoprotein on the Blood-Brain Barrier Transport of the Antidepressant Escitalopram: Converging Evidence from In Vivo and In Vitro Studies British Pharmacological Society (BPS) Winter Meeting, London, December 2012 [Details]
(2012)American Association of Pharmaceutical Scientists Annual Meeting and Exposition (AAPS) Chicago, USA, October 2012
O’Brien FE, Clarke G, Dinan TG, Cryan JF, Griffin BT (2012) P-glycoprotein limits antidepressant transport across the blood-brain barrier: converging evidence from in vitro and in vivo studies American Association of Pharmaceutical Scientists Annual Meeting and Exposition (AAPS) Chicago, USA, October 2012 [Details]
(2012)Neurogastroenterology and Motility, Bologna, Italy, September 2012
Kennedy PJ, Clarke G, O’Neill A, Groeger JA, Quigley EM, Shanahan F , Cryan JF, Dinan TG (2012) An evaluation of neuropsychological performance in Irritable Bowel Syndrome (IBS): Relationship between altered visuo-spatial memory function, salivary cortisol levels and tryptophan metabolism along the kynurenine pathway Neurogastroenterology and Motility, Bologna, Italy, September 2012 [Details]
(2012)Digestive Disease Week (San Diego, USA, May 2012)
Kennedy PJ, Clarke G, O’Neill A, Groeger JA, Quigley EM, Shanahan F , Cryan JF, Dinan TG (2012) An assessment of cognitive function in irritable bowel syndrome (IBS): Are deficits in episodic memory stress-related and mediated by tryptophan metabolism along the kynurenine pathway? Digestive Disease Week (San Diego, USA, May 2012) [Details]
(2012)Digestive Disease Week (San Diego, USA, May 2012)
Clarke G, Grenham S, Scully P, Fitzgerald P, Shanahan F, Dinan TG, Cryan JF (2012) Regulation of Serotonergic Neurotransmission and Behaviour by the Brain-Gut-Microbiome Axis Digestive Disease Week (San Diego, USA, May 2012) [Details]
(2011)College of Medicine and Health Research Day (Brookfield, UCC, June 2011)
O’Brien FE, Clarke G, Fitzgerald P, Griffin BT, Cryan JF (2011) An integrated microdialysis model for the analysis of blood-brain barrier drug transport in the conscious freely moving rat College of Medicine and Health Research Day (Brookfield, UCC, June 2011) [Details]
(2010)7th World Congress on Stress (Leiden, Holland, August 2010)
Julio M, O’Mahony C, Clarke G, Bravo J, Dinan TG, Cryan JF (2010) Strain-specific alterations in colon 5-HT levels correlate to defecation responses in chronically stressed mice 7th World Congress on Stress (Leiden, Holland, August 2010) [Details]
(2010)Psychoneuroimmunology Research Society (Trinity College, Dublin, June 2010)
Scully P, Clarke G, Grenham S, Fitzgerald P, O’Mahony CM, ,McKernan DP,Tramullas M,Shanahan F, Dinan TG, & Cryan JF (2010) Gender-Dependent Influence of the Gut Microbiome on the Hippocampal 5-HT System Psychoneuroimmunology Research Society (Trinity College, Dublin, June 2010) [Details]
(2010)Health and Medicine Research Day (Brookfield, Cork, June 2010)
9. Scully P, Clarke G, Grenham S, Fitzgerald P, O’Mahony CM, ,McKernan DP,Tramullas M,Shanahan F, Dinan TG, & Cryan JF (2010) Gender-Dependent Influence of the Gut Microbiome on the Hippocampal 5-HT System Health and Medicine Research Day (Brookfield, Cork, June 2010) [Details]
(2010)Society for Neuroscience (San Diego, USA, November 2010)
Tramullas M, Clarke G, Shanahan F, Dinan TG, Cryan JF (2010) The gut microbiome alters toll-like receptor and cytokine expression levels in the spinal cord: Role of gender Society for Neuroscience (San Diego, USA, November 2010) [Details]
(2010)Society for Neuroscience (San Diego, USA, November 2010)
Cryan JF, Clarke G, Grenham S, Scully P, Shanahan F, Dinan TG (2010) The gut microbiome markedly influences hippocampal neurotransmission in the mouse: Role of gender Society for Neuroscience (San Diego, USA, November 2010) [Details]
(2009)European College of Neuropsychopharmacology (Workshop on Neuropsychopharmacology for Young Scientists in Europe,Nice, France, March 2009)
Browne CA, Clarke G., Dinan TG, Cryan JF (2009) Restraint stress alters tryptophan hydroxylase 2 activity in BALB/c mice: relevance to depression European College of Neuropsychopharmacology (Workshop on Neuropsychopharmacology for Young Scientists in Europe,Nice, France, March 2009) [Details]
(2009)Neuroscience Ireland (Trinity College Dublin, September 2009)
Browne, CA,Clarke, G,Dinan, TG,Cryan, JF (2009) BEHAVIOURAL EFFECTS OF DIETARY TRYPOTPHAN MANIPULATIONS ON C57BL/6J AND BALB/C MICE Neuroscience Ireland (Trinity College Dublin, September 2009) , pp.112-113 [Details]
(2009)Digestive Disease Week (Chicago, USA, June 2009)
Clarke G, Fitzgerald P, Hennessy AA, Cassidy EM, Quigley EMM, Ross P, Stanton C, Cryan JF, Dinan TG. (2009) Polyunsaturated fatty acids contribute to the inflammatory phenotype in irritable bowel syndrome Digestive Disease Week (Chicago, USA, June 2009) [Details]
(2009)European College of Neuropsychopharmacology (Istanbul, Turkey, September 2009)
Clarke, G,O'Mahony, SM,Ross, P,Stanton, C,Cryan, JE,Dinan, TG (2009) Chain reactions: polyunsaturated fatty acids and the depressive phenotype in maternally separated rodents European College of Neuropsychopharmacology (Istanbul, Turkey, September 2009) , pp.337-338 [Details]
(2008)Digestive Disease Week (San Diego, USA, May 2008)
Fitzgerald P, Clarke G, Scully P, Cryan JF, Shanahan F, Quigley EMM, Cassidy EM, Dinan TG (2008) Tryptophan catabolism in irritable bowel syndrome: Relationship to cytokines, severity and psychiatric comorbidity Digestive Disease Week (San Diego, USA, May 2008) [Details]
(2008)Second Joint International Meeting for Neurogastroenterology and Motilit (Lucerne, Switzerland, November 2008)
Clarke G, Fitzgerald P, Cryan JF, Dinan TG (2008) Increased tryptophan metabolism in irritable bowel syndrome (IBS)–an immune mediated phenomenon? Second Joint International Meeting for Neurogastroenterology and Motilit (Lucerne, Switzerland, November 2008) [Details]
(2008)Digestive Disease Week (San Diego, USA, May 2008)
Clarke G, Fitzgerald P, Cryan JF, Cassidy EM,Quigley EMM, Dinan TG. (2008) Altered kynurenine pathway metabolism in Irritable Bowel Syndrome (IBS)-Evidence of indoleamine 2,3-dioxygenase (IDO) activation in a male cohort Digestive Disease Week (San Diego, USA, May 2008) [Details]
(2008)Irish Society of Gastroenterology (Sligo, Ireland, April 2008)
Clarke G, Fitzgerald P, Cassidy E, Cryan JF, Quigley EM, Dinan T (2008) Increased tryptophan degradation along the kynurenine pathway in Irritable Bowel Syndrome (IBS)-Evidence of an immune mediated indoleamine 2,3-dioxygenase (IDO) activation in a male cohort Irish Society of Gastroenterology (Sligo, Ireland, April 2008) [Details]
(2008)International Neuroimmunology Symposium (University College Dublin, Dublin, Ireland, March 2008)
Clarke G, Fitzgerald P, Cryan JF, Cassidy EM,Quigley EMM, Dinan TG (2008) Tryptophan Degradation and Irritable Bowel Syndrome (IBS)-Evidence of an immune mediated indoleamine-2,3-dioxygenase (IDO) activation in a male cohort International Neuroimmunology Symposium (University College Dublin, Dublin, Ireland, March 2008) [Details]
(2009)European College of Neuropsychopharmacology (Workshop on Neuropsychopharmacology for Young Scientists in Europe, Nice, France, March 2009)
O’ Mahony. C.M., Bravo, J., Dinan. T.G. and Cryan. J.F. (2009) Comparison of stress-induced alterations in hippocampal mGlur7 mRNA in two animal models of depression European College of Neuropsychopharmacology (Workshop on Neuropsychopharmacology for Young Scientists in Europe, Nice, France, March 2009) , pp.67-68 [Details]
(2008)European Behavioural Pharmacology Society Workshop on Behavioural Genetics and Neuropsychiatric Disorders (Cork, Ireland, September 2008)
Clarke, G,O'Mahony, S,Hyland, NP,Fitzgerald, P,Dinan, TG,Cryan, JF (2008) Beta3 adrenoceptor modulation of visceral pain - A possible role for the kynurenine pathway? European Behavioural Pharmacology Society Workshop on Behavioural Genetics and Neuropsychiatric Disorders (Cork, Ireland, September 2008) , pp.671-672 [Details]
(2008)EURON workshop (Bad Honnef,November 2007)
Clarke, G, Barry, S, Scully, P, Cryan, JF, Dinan, TG; (2008) Simultaneous measurement of tryptophan and its kynurenine pathway metabolites by HPLC: evidence of increased tryptophan degradation in psychosis EURON workshop (Bad Honnef,November 2007) , pp.67-68 [Details]
(2008)Second Joint International Meeting for Neurogastroenterology and Motility, Lucerne, Switzerland, November 2008
Clarke G, Mahony SM, Hyland NP, Fitzgerald P, Cryan JF, Dinan TG (2008) Visceral pain and beta3 adrenoceptor modulation a role for the kynurenine pathway? Second Joint International Meeting for Neurogastroenterology and Motility, Lucerne, Switzerland, November 2008 [Details]
(2008)Second Joint International Meeting for Neurogastroenterology and Motility, Lucerne, Switzerland, November 2008
Clarke G, Mahony SM, Hyland NP, Fitzgerald P, Cryan JF, Dinan TG (2008) Visceral pain and beta3 adrenoceptor modulation a role for the kynurenine pathway? Second Joint International Meeting for Neurogastroenterology and Motility, Lucerne, Switzerland, November 2008 [Details]
(2007)European College of Neuropsychopharmacology (ECNP, Vienna 2007)
Mahony, SO,Clarke, G,Mahony, LO,Quigley, E,Cryan, J,Dinan, TG (2007) Depressive behaviours and alterations in the immune and stress response systems following neonatal maternal separation European College of Neuropsychopharmacology (ECNP, Vienna 2007) , pp.280-280 [Details]
(2006)Neuroscience Ireland (Cork September 2006)
Clarke G, O'Mahony S, Malone G, Dinan TG. (2006) Determination of GABA and glutamate in discrete regions of the rodent brain Neuroscience Ireland (Cork September 2006) [Details]
(2004)Collegium Internationale Neuro-Psychopharmacologicum (24th CINP Congress Paris, France, June 2004)
Stockmeier CA, Shi X, Trojecka A, Clarke G, Konick L, Overholser JC, Jurjus G, Meltzer HY, Friedman L, Rajkowska G (2004) Decrease in serotonin-1A receptors in orbitofrontal cortex in depression Collegium Internationale Neuro-Psychopharmacologicum (24th CINP Congress Paris, France, June 2004) [Details]
(2004)Collegium Internationale Neuro-Psychopharmacologicum (24th CINP Congress, Paris, France, June 2004)
Rajkowska G, Dubey P, Clarke G, Ni Thuairisg S, Mahajan G, Licht C, Van de Werd H, Miguel-Hidalgo JJ, Yuan P, Manji HK, Uylings HB. (2004) Glial number is increased in hippocampus but not prefrontal cortex in lithium-treated mice - A stereological study Collegium Internationale Neuro-Psychopharmacologicum (24th CINP Congress, Paris, France, June 2004) [Details]

Invited papers

YearPublication
(2009)A serological test for irritable bowel syndrome (IBS): real meat or bare bones?.
Quigley EMM, Clarke G (2009) A serological test for irritable bowel syndrome (IBS): real meat or bare bones?. Invited papers [Details]

Reviews

YearPublication
(2014)Priming for health: gut microbiota acquired in early life regulates physiology, brain and behaviour.
Clarke, G,O'Mahony, SM,Dinan, TG,Cryan, JF (2014) Priming for health: gut microbiota acquired in early life regulates physiology, brain and behaviour. Reviews [DOI] [Details]
(2014)The microbiome: stress, health and disease.
Moloney, RD,Desbonnet, L,Clarke, G,Dinan, TG,Cryan, JF (2014) The microbiome: stress, health and disease. Reviews [DOI] [Details]
(2014)Biological and psychological markers of stress in humans: Focus on the Trier Social Stress Test.
Allen, AP,Kennedy, PJ,Cryan, JF,Dinan, TG,Clarke, G (2014) Biological and psychological markers of stress in humans: Focus on the Trier Social Stress Test. Reviews [DOI] [Details]
(2014)A review of ketamine in affective disorders: Current evidence of clinical efficacy, limitations of use and pre-clinical evidence on proposed mechanisms of action.
Naughton, M,Clarke, G,O'Leary, OF,Cryan, JF,Dinan, TG (2014) A review of ketamine in affective disorders: Current evidence of clinical efficacy, limitations of use and pre-clinical evidence on proposed mechanisms of action. Reviews [DOI] [Details]

Review Articles

YearPublication
(2012)Probiotics for the Treatment of Irritable Bowel Syndrome: Focus on Lactic Acid Bacteria.
Clarke G, Cryan JF, Dinan TG, Quigley EM (2012) Probiotics for the Treatment of Irritable Bowel Syndrome: Focus on Lactic Acid Bacteria. Review Articles [Details]
(2012)Gut Memories: Towards a Cognitive Neurobiology of Irritable Bowel Syndrome.
Kennedy P, Clarke G, Groeger J, Quigley EMM, Cryan J, Dinan T (2012) Gut Memories: Towards a Cognitive Neurobiology of Irritable Bowel Syndrome. Review Articles [Details]
(2011)Brain-Gut-Microbe communication in health and disease.
Grenham S, Clarke G, Cryan JF, Dinan TG (2011) Brain-Gut-Microbe communication in health and disease. Review Articles [Details]
(2009)Irritable bowel syndrome: towards biomarker identification.
Clarke G, Quigley EMM, Cryan JF, Dinan TG (2009) Irritable bowel syndrome: towards biomarker identification. Review Articles [Details]

Honours and Awards

 YearTitleAwarding Body
2014NARSAD Young Investigator Brain and Behaviour Research Foundation
2011American Neurogastroenterology and Motility Society Research Award American Neurogastroenterology and Motility Society
2011Oral Presentation Award, United European Gastroenterology Week United European Gastroenterology Federation
2009European College of Neuropsychopharmacology Travel Award (Istanbul, Turkey) European College of Neuropsychopharmacology
2008European College of Neuropsychopharmacology Young Scientists Travel Award (Nice, France) European College of Neuropsychopharmacology

Professional Associations

 AssociationFunctionFrom / To
European College of Neuropsychopharmacology (ECNP) Member/
Physiology Society Member/
American Neurogastroenterology and Motility Society (ANMS) Member/
International College of Neuropsychopharmacology (CINP) Member/
Neuroscience Ireland Member/
International Society for Nutritional Psychiatry Research (ISNPR) Member/

Conference Contributions

YearPublication
(2014)Society for Neuroscience (SFN) Neuroscience 2014, November 15-19, Washington, USA,
Kennedy PJ, Allen AP, O’Neill A, Quigley EMM, Cryan JF, Dinan TG and Clarke G (2014) Acute tryptophan depletion modulates kynurenine production: Implications for treatment of cognitive impairment in brain-gut axis disorders. [Poster Presentation], Society for Neuroscience (SFN) Neuroscience 2014, November 15-19, Washington, USA, Washington , 15-NOV-14 - 19-SEP-14. [Details]
(2014)Society for Neuroscience (SFN) Neuroscience 2014, November 15-19, Washington, USA,
Clarke G, Naughton M, O’Shea R, Dowling J, Walsh A, Ismail F, Shorten G, Scott L, Cryan JF, Dinan TG. (2014) Rapid antidepressant response to ketamine in treatment-resistant depression is not dependent on normalising kynurenine pathway metabolism. [Poster Presentation], Society for Neuroscience (SFN) Neuroscience 2014, November 15-19, Washington, USA, Washington , 15-NOV-14 - 19-SEP-14. [Details]
(2014)Society for Neuroscience (SFN) Neuroscience 2014, November 15-19, Washington, USA,
Moloney G, O' Leary O, Desbonnet L, Shanahan F, Dinan TG, Clarke G, Cryan JF (2014) Microbiota regulates microRNA expression in the hippocampus in a sex dependent manner. [Poster Presentation], Society for Neuroscience (SFN) Neuroscience 2014, November 15-19, Washington, USA, Washington , 15-NOV-14 - 19-NOV-14. [Details]
(2014)Society for Neuroscience (SFN) Neuroscience 2014, November 15-19, Washington, USA,
Allen AP, Naughton M, Clarke G, O’Shea R, Dowling J, Walsh A, Ismail F, Shorten G, Scott L, Cryan JF, Dinan TG (2014) A delayed brain-derived neurotrophic factor response to ketamine infusion: Implications for rapid symptom improvements in treatment-resistant depression. [Poster Presentation], Society for Neuroscience (SFN) Neuroscience 2014, November 15-19, Washington, USA, Washington , 15-NOV-14 - 19-NOV-14. [Details]
(2014)Society for Neuroscience (SFN) Neuroscience 2014, November 15-19, Washington, USA,
Borre YE, Hecke Morais L, Golubeva AV, Patterson E, Crispie F, Moloney RD, Scott KA, Stilling R, Hyland NP, Clarke G, Stanton C, Cotter PD, Dinan TG, Cryan JF (2014) Mode of delivery at birth and behavioural outcomes: Rewiring of the brain-gut-microbiome axis?. [Poster Presentation], Society for Neuroscience (SFN) Neuroscience 2014, November 15-19, Washington, USA, Washington , 15-NOV-14 - 19-NOV-14. [Details]
(2014)Society for Neuroscience (SFN) Neuroscience 2014, November 15-19, Washington, USA,
Scott KA, Moloney G, Naughton M, O'Connor RM, McLoughlin DM, Dowling J, Shorten G, Walsh A, Scott L, Ismail F, Clarke G, Dinan TG, Cryan JF (2014) Whole blood microRNAs as biomarkers of treatment-resistant depression? Effects of ketamine and electroconvulsive therapy. [Poster Presentation], Society for Neuroscience (SFN) Neuroscience 2014, November 15-19, Washington, USA, Washington , 15-NOV-14 - 19-NOV-14. [Details]
(2014)27th European College of Neuropsychopharmacology Congress (ECNP), 18th-21st October 2014, Berlin, Germany,
Kennedy PJ, Allen AP, O’Neill A, Quigley EMM, Cryan JF, Dinan TG and Clarke G (2014) Acute Typtophan depletion modulates Kynurenine production: A challenging component of cognitive impairment in brain-gut axis disorders. [Poster Presentation], 27th European College of Neuropsychopharmacology Congress (ECNP), 18th-21st October 2014, Berlin, Germany, Berlin , 18-OCT-14 - 21-SEP-14. [Details]
(2014)27th European College of Neuropsychopharmacology Congress (ECNP), 18th-21st October 2014, Berlin, Germany,
Clarke G, Naughton M, O’Shea R, Dowling J, Walsh A, Ismail F, Shorten G, Scott L, Cryan JF, Dinan TG. Biological Markers of the Rapid Antidepressant Response to Ketamine in Treatment-resistant Depression: Focus on the Kynurenine Pathway of Tryptophan Metabolism (2014) Biological Markers of the Rapid Antidepressant Response to Ketamine in Treatment-resistant Depression: Focus on the Kynurenine Pathway of Tryptophan Metabolism. [Poster Presentation], 27th European College of Neuropsychopharmacology Congress (ECNP), 18th-21st October 2014, Berlin, Germany, Berlin , 18-OCT-14 - 21-OCT-14. [Details]
(2014)27th European College of Neuropsychopharmacology Congress (ECNP), 18th-21st October 2014, Berlin, Germany,
Allen AP, Naughton M, Clarke G, O’Shea R, Dowling J, Walsh A, Ismail F, Shorten G, Scott L, Cryan JF, Dinan TG (2014) Serum brain-derived neurotrophic factor and symptom improvements post-ketamine treatment in treatment-resistant depression. [Poster Presentation], 27th European College of Neuropsychopharmacology Congress (ECNP), 18th-21st October 2014, Berlin, Germany, Berlin , 18-OCT-14 - 21-SEP-14. [Details]
(2014)27th European College of Neuropsychopharmacology Congress (ECNP), 18th-21st October 2014, Berlin, Germany,
Naughton M, Allen AP, Clarke G, O’Shea R, Dowling J, Walsh A, Ismail F, Shorten G, Scott L, Cryan JF, Dinan TG. (2014) The cortisol awakening response in treatment-resistant depression is not a biomarker of the clinical response to ketamine. [Poster Presentation], 27th European College of Neuropsychopharmacology Congress (ECNP), 18th-21st October 2014, Berlin, Germany, Berlin , 18-OCT-14 - 21-SEP-14. [Details]
(2014)Young Neuroscientists Symposium (YNS) 2014 20th September 2014, Trinity Biomedical Sciences Institute, Trinity College Dublin,
Naughton M, Allen AP, Clarke G, Dowling J, Walsh A, Ismail F, Shorten G, Scott L, Cryan JF, Dinan TG. (2014) Biomarkers of ketamine efficacy in treatment-resistant depression: Focus on BDNF. [Poster Presentation], Young Neuroscientists Symposium (YNS) 2014 20th September 2014, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin , 20-SEP-14 - 20-SEP-14. [Details]
(2014)Young Neuroscientists Symposium (YNS) 2014 20th September 2014, Trinity Biomedical Sciences Institute, Trinity College Dublin,
Hoban AE, Stilling RM, Desbonnet L, Shanahan F, Dinan TG, Cryan JF, Clarke, G (2014) Regulation of microRNAs in the Amygdala by the Gut Microbiota: Implications for Brain and Behaviour. [Poster Presentation], Young Neuroscientists Symposium (YNS) 2014 20th September 2014, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin , 20-SEP-14 - 20-SEP-14. [Details]
(2014)International College of Neuropsychopharmacology (CINP) 29th World Congress Vancouver 22 – 26 June 2014,
Kennedy PJ, Allen AP, O’Neill A, Quigley EMM, Cryan JF, Dinan TG and Clarke G. (2014) Kynurenine production is reduced by acute typtophan depletion: Implications for cognitive impairment in brain-gut axis disorders. [Poster Presentation], International College of Neuropsychopharmacology (CINP) 29th World Congress Vancouver 22 – 26 June 2014, Vancouver , 22-JUN-14 - 26-JUN-14. [Details]
(2014)Digestive Disease Week (DDW) Chicago May 2014,
Kennedy PJ, Allen AP, O’Neill A, Quigley EMM, Cryan JF, Dinan TG and Clarke G. (2014) Acute Tryptophan Depletion Reduces Kynurenine Levels: Implications for Treatment of Impaired Visuospatial Memory Performance in Irritable Bowel Syndrome. [Poster Presentation], Digestive Disease Week (DDW) Chicago May 2014, Chicago , 03-MAY-14 - 06-MAY-14. [Details]
(2014)2014 Pediatric Academic Societies and Asian Society for Pediatric Research Joint Meeting in Vancouver, BC, Canada, May 3-6,
O’Rourke L, Clarke G, Nolan A, Dinan TG, Stanton C, Ryan CA (2014) The Relationship Between Maternal Tryptophan Metabolism, Cytokines and Cortisol in Term and Preterm Expressed Breast Milk. [Poster Presentation], 2014 Pediatric Academic Societies and Asian Society for Pediatric Research Joint Meeting in Vancouver, BC, Canada, May 3-6, Vancouver , 03-MAY-14 - 06-MAY-14. [Details]
(2014)ECNP Workshop for Junior Scientists in Europe, 6-9 March 2014, Nice, France,
Kennedy PJ, Allen AP, O’Neill A, Quigley EMM, Cryan JF, Dinan TG and Clarke G (2014) Acute Typtophan depletion modulates Kynurenine production: A challenging component of cognitive impairment in brain-gut axis disorders. [Poster Presentation], ECNP Workshop for Junior Scientists in Europe, 6-9 March 2014, Nice, France, Nice , 06-MAR-14 - 09-MAR-14. [Details]
(2014)Digestive Disease Week (DDW) Chicago May 2014,
Arijs I, Wollants WJ, Clarke G, Persoons P, Van Lommel L, Machiels K, Ferrante M, Schuit F, Vermeire S, Rutgeerts P. (2014) The effect of infliximab therapy on the tryptophan metabolism and indoleamine 2,3-dioxygenase expression (IDO) in patients with inflammatory bowel disease. [Poster Presentation], Digestive Disease Week (DDW) Chicago May 2014, Chicago , 03-MAY-14 - 06-MAY-14. [Details]
(2013)Irish Paediatric Association Annual Meeting, Dublin, Ireland 8-9th November 2013,
O’Rourke L, Clarke G, Nolan A, Dinan TG, Stanton C, Ryan CA (2013) Tryptophan and its kynurenine pathway metabolites in breastmilk. Influence of maternal stress and immune status and developmental relevance. [Poster Presentation], Irish Paediatric Association Annual Meeting, Dublin, Ireland 8-9th November 2013, Dublin , 08-NOV-13 - 09-NOV-13. [Details]
(2013)3rd Annual UK & Ireland Early Career BBB Symposium, Cambridge, UK, 22 November 2013,
O’Brien FE, Clarke G, Dinan TG, Griffin BT, Cryan JF. (2013) P-glycoprotein inhibition as a strategy to augment antidepressant delivery across the blood-brain barrier: preclinical pharmacokinetic and pharmacodynamic studies. [Poster Presentation], 3rd Annual UK & Ireland Early Career BBB Symposium, Cambridge, UK, 22 November 2013, Cambridge , 22-NOV-13. [Details]
(2013)European Society for Paediatric Research, Porto, Portugal, October 2013,
Looney AM, Walsh BH, Grenham S, Moloney G, Clarke G, Cryan JF, Dinan TG, Boylan GB, Murray DM (2013) The expression profile of miRNA in the umbilical cord blood of infants with hypoxic ischaemic encephalopathy; potential biomarkers of injury. [Poster Presentation], European Society for Paediatric Research, Porto, Portugal, October 2013, Porto, Portugal , 02-OCT-13 - 04-OCT-13. [Details]
(2013)United European Gastroenterology Week, Berlin, Germany, October 2013,
Kennedy PJ, Clarke G, Allen AP, Ann O’Neill A, Groeger JA, Quigley EM, Shanahan F , Cryan JF, Dinan TG. (2013) A prospective study of cognitive performance in irritable bowel syndrome: visuospatial memory deficits as a stable feature. [Poster Presentation], United European Gastroenterology Week, Berlin, Germany, October 2013, Berlin , 10-OCT-13. [Details]
(2013)Neuroscience Ireland, Cork, Ireland September 2013,
Kennedy PJ, Allen AP, O’Neill A, Quigley EMM, Cryan JF, Dinan TG, Clarke G (2013) A role for the kynurenine pathway in neuropsychological performance following acute tryptophan depletion?. [Poster Presentation], Neuroscience Ireland, Cork, Ireland September 2013, Cork , 22-SEP-13. [Details]
(2013)Neuroscience Ireland, Cork, Ireland September 2013,
Desbonnet L, Clarke G, Shanahan F, Dinan TG, Cryan JF (2013) Microbiota is essential for social development in the mouse. [Poster Presentation], Neuroscience Ireland, Cork, Ireland September 2013, Cork , 22-SEP-13. [Details]
(2013)International Society of Psychoneuroendocrinology (ISPNE), Leiden, Netherlands, August 2013,
Kennedy P, Clarke G, Groeger J, Quigley EMM, Cryan J, Dinan T (2013) Sustained Hypothalamic-Pituitary-Adrenal-Axis Response to Acute Psychosocial Stress in Irritable Bowel Syndrome. [Poster Presentation], International Society of Psychoneuroendocrinology (ISPNE), Leiden, Netherlands, August 2013, Leiden, Netherlands , 15-AUG-13 - 16-AUG-13. [Details]
(2013)International Behavioural Neuroscience Society, Dublin, June 2013,
Kennedy PJ, O’Mahony, Clarke G, Dinan TG, Cryan JF (2013) Impaired contextual fear extinction and novel object recognition memory in a chronic psychosocial stress mouse model of brain-gut axis dysfunction. [Poster Presentation], International Behavioural Neuroscience Society, Dublin, June 2013, Dublin , 24-JUN-13 - 29-JUN-13. [Details]
(2013)Royal Academy of Medicine in Ireland (RAMI) Annual Meeting, University College Cork, June 2013,
Ogbonnaya S, Clarke G, Shanahan FS, Cryan JF, O’Leary OF (2013) Establishment of the gut microbiome during early life influences the survival of newly-born cells in the adult hippocampus. [Poster Presentation], Royal Academy of Medicine in Ireland (RAMI) Annual Meeting, University College Cork, June 2013, Cork , 20-JUN-13 - 20-JUN-13. [Details]
(2013)Royal Academy of Medicine in Ireland (RAMI) Annual Meeting, University College Cork, June 2013,
O’Brien FE, O’Connor RM, Clarke G, Dinan TG, Griffin BT, Cryan JF (2013) Effect of P-glycoprotein Inhibition on the brain distribution and antidepressant-like activity of escitalopram in rodents. [Poster Presentation], Royal Academy of Medicine in Ireland (RAMI) Annual Meeting, University College Cork, June 2013, Cork , 20-JUN-13 - 20-JUN-13. [Details]
(2013)Digestive Disease Week, Florida, USA, May 2013,
Kennedy PJ, Clarke G, Allen AP, Ann O’Neill A, Groeger JA, Quigley EM, Shanahan F , Cryan JF, Dinan TG (2013) A Prospective Assessment of Cognitive Performance in Irritable Bowel Syndrome Reveals Persistent Visuospatial Memory Deficits. [Poster Presentation], Digestive Disease Week, Florida, USA, May 2013, Florida, USA , 18-MAY-13 - 22-MAY-13. [Details]
(2013)British and Irish Gastroenterology (BIG) Spring Meeting, Belfast, April 2013,
Kennedy PJ, Clarke G, Allen AP, Ann O’Neill A, Groeger JA, Quigley EM, Shanahan F , Cryan JF, Dinan TG (2013) A Prospective Study of Cognitive Performance in Irritable Bowel Syndrome: Visuospatial Memory Deficits as a Stable Feature. [Poster Presentation], British and Irish Gastroenterology (BIG) Spring Meeting, Belfast, April 2013, Belfast , 11-APR-13 - 13-APR-13. [Details]
(2012)American Association of Pharmaceutical Scientists Annual Meeting and Exposition (AAPS) Chicago, USA, October 2012,
O’Brien FE, Clarke G, Dinan TG, Cryan JF, Griffin BT (2012) P-glycoprotein limits antidepressant transport across the blood-brain barrier: converging evidence from in vitro and in vivo studies. [Poster Presentation], American Association of Pharmaceutical Scientists Annual Meeting and Exposition (AAPS) Chicago, USA, October 2012, Chicago , 03-OCT-12 - 04-OCT-12. [Details]
(2012)Neuroscience Ireland, RCSI, Dublin, 2012,
O’Brien FE, Clarke G, Dinan TG, Cryan JF, Griffin BT (2012) P-glycoprotein restricts blood-brain barrier transport of the antidepressant escitalopram: converging evidence from in vitro and in vivo studies. [Poster Presentation], Neuroscience Ireland, RCSI, Dublin, 2012, Dublin , 06-SEP-12 - 07-SEP-12. [Details]
(2012)Neurogastroenterology and Motility, Bologna, Italy, 2012,
Kennedy PJ, Clarke G, O’Neill A, Groeger JA, Quigley EM, Shanahan F , Cryan JF, Dinan TG (2012) An evaluation of neuropsychological performance in Irritable Bowel Syndrome (IBS): Relationship between altered visuo-spatial memory function, salivary cortisol levels and tryptophan metabolism along the kynurenine pathway. [Poster Presentation], Neurogastroenterology and Motility, Bologna, Italy, 2012, Bologna , 06-SEP-12 - 08-SEP-12. [Details]
(2012)Neurogastroenterology and Motility, Bologna, Italy, 2012,
Clarke G, Grenham S, Scully P, Fitzgerald P, Shanahan F, Dinan TG, Cryan JF (2012) The Microbiome-Gut-Brain Axis as a Regulator of Serotonergic Neurotransmission and Behaviour. [Poster Presentation], Neurogastroenterology and Motility, Bologna, Italy, 2012, Bologna , 06-SEP-12 - 08-SEP-12. [Details]
(2012)British Pharmacological Society (BPS) Winter Meeting, London, December 2012,
O’Brien FE, Clarke G, Dinan TG, Cryan JF, Griffin BT (2012) The Influence of P-glycoprotein on the Blood-Brain Barrier Transport of the Antidepressant Escitalopram: Converging Evidence from In Vivo and In Vitro Studies. [Poster Presentation], British Pharmacological Society (BPS) Winter Meeting, London, December 2012, London , 17-DEC-12 - 19-DEC-12. [Details]
(2012)Stanely Meeting, Baltimore, USA, December 2012,
Clarke, G (2012) Mind-Altering Microorganisms. [Invited Oral Presentation], Stanely Meeting, Baltimore, USA, December 2012, Baltimore , 10-DEC-12 - 12-DEC-13. [Details]
(2012)Digestive Disease Week, San Diego, USA, May 2012,
Kennedy PJ, Clarke G, O’Neill A, Groeger JA, Quigley EM, Shanahan F , Cryan JF, Dinan TG (2012) Are deficits in episodic memory stress-related and mediated by tryptophan metabolism along the kynurenine pathway?. [Poster Presentation], Digestive Disease Week, San Diego, USA, May 2012, San Diego , 19-MAY-12 - 22-MAY-12. [Details]
(2012)Digestive Disease Week, San Diego, USA, May 2012,
Clarke G, Grenham S, Scully P, Fitzgerald P, Moloney, RD, Shanahan F, Dinan TG, Cryan JF (2012) Regulation of Serotonergic Neurotransmission and Behaviour by the Brain-Gut-Microbiome Axis. [Poster Presentation], Digestive Disease Week, San Diego, USA, May 2012, San Diego , 19-MAY-12 - 22-MAY-12. [Details]
(2011)College of Medicine and Health Research Day, UCC, June 2011,
O’Brien FE, Clarke G, Fitzgerald P, Griffin BT, Cryan JF (2011) An integrated microdialysis model for the analysis of blood-brain barrier drug transport in the conscious freely moving rat. [Poster Presentation], College of Medicine and Health Research Day, UCC, June 2011, Cork , 22-JUN-11 - 22-JUN-11. [Details]
(2011)United European Gastroenterology Week (UEGW), Stockholm, Sweden, October 2011,
Clarke G (2011) The Gut Microbiome During Early-Life Regulates The Development Of The Adult Brain Serotonergic System. [Invited Oral Presentation], United European Gastroenterology Week (UEGW), Stockholm, Sweden, October 2011, Stockholm , 22-OCT-11 - 26-OCT-11. [Details]
(2011)Digestive Disease Week, Chicago, USA, May 2011,
Clarke, G (2011) Increased Kynurenine Production Following Toll-Like Receptor (TLR) Activation: A Novel Role for TLR8 in Irritable Bowel Syndrome (IBS). [Invited Oral Presentation], Digestive Disease Week, Chicago, USA, May 2011, Chicago , 07-MAY-11 - 10-MAY-12. [Details]
(2011)College of Medicine and Health Research Day 2011, Brookfield, UCC,
Clarke, G (2011) The Gut Microbiome During Early-Life Regulates The Development Of The Adult Brain Serotonergic System. [Invited Oral Presentation], College of Medicine and Health Research Day 2011, Brookfield, UCC, Cork , 22-JUN-11 - 22-JUN-11. [Details]
(2010)Society for Neuroscience, San Diego, USA, November 2010,
Tramullas M, Clarke G, Shanahan F, Dinan TG, Cryan JF (2010) The gut microbiome alters toll-like receptor and cytokine expression levels in the spinal cord: Role of gender. [Poster Presentation], Society for Neuroscience, San Diego, USA, November 2010, San Diego , 13-NOV-10 - 17-NOV-10. [Details]
(2010)7th World Congress on Stress, Leiden, Holland, August 2010,
Julio M, O’Mahony C, Clarke G, Bravo J, Dinan TG, Cryan JF (2010) Strain-specific alterations in colon 5-HT levels correlate to defecation responses in chronically stressed mice. [Poster Presentation], 7th World Congress on Stress, Leiden, Holland, August 2010, Leiden , 25-AUG-12 - 27-AUG-12. [Details]
(2010)European College of Neuropsychopharmacology (ECNP), Istanbul, Turkey, 2009,
Clarke, G (2010) On the origin of inflammation in depression: A role for polyunsaturated fatty acids. [Invited Oral Presentation], European College of Neuropsychopharmacology (ECNP), Istanbul, Turkey, 2009, Istanbul , 12-SEP-10 - 16-SEP-10. [Details]
(2010)Society for Neuroscience, San Diego, USA, November 2010,
Cryan JF, Clarke G, Grenham S, Scully P, Shanahan F, Dinan TG (2010) The gut microbiome markedly influences hippocampal neurotransmission in the mouse: Role of gender. [Poster Presentation], Society for Neuroscience, San Diego, USA, November 2010, San Diego , 13-NOV-10 - 17-NOV-10. [Details]
(2010)Health and Medicine Research Day, Brookfield, Cork, June 2010,
Scully P, Clarke G, Grenham S, Fitzgerald P, O’Mahony CM,McKernan DP,Tramullas M,Shanahan F, Dinan TG, & Cryan JF (2010) Gender-Dependent Influence of the Gut Microbiome on the Hippocampal 5-HT System. [Poster Presentation], Health and Medicine Research Day, Brookfield, Cork, June 2010, Cork , 16-JUN-10 - 16-JUN-10. [Details]
(2010)Digestive Disease Week, New Orleans, USA, May 2010,
Clarke, G (2010) The Brain-Gut-Microbiome Axis: Gender and region-specific effects of the microbiome on central neurotransmitter and neurotrophin levels. [Conference Organising Committee Chairperson], Digestive Disease Week, New Orleans, USA, May 2010, New Orleans , 01-MAY-10 - 05-MAY-10. [Details]
(2010)Psychoneuroimmunology Research Society, Trinity College, Dublin, June 2010,
Scully P, Clarke G, Grenham S, Fitzgerald P, O’Mahony CM, ,McKernan DP,Tramullas M,Shanahan F, Dinan TG, & Cryan JF (2010) Gender-Dependent Influence of the Gut Microbiome on the Hippocampal 5-HT System. [Poster Presentation], Psychoneuroimmunology Research Society, Trinity College, Dublin, June 2010, Dublin , 02-JUN-10 - 05-JUN-10. [Details]
(2009)European College of Neuropsychopharmacology, Istanbul, Turkey, September 2009,
Clarke G, O'Mahony SM, Hennessy AA, Ross P, Stanton C, Cryan JF, Dinan TG (2009) Chain reactions: Polyunsaturated fatty acids and the depressive phenotype in maternally separated rodents. [Poster Presentation], European College of Neuropsychopharmacology, Istanbul, Turkey, September 2009, Istanbul , 12-SEP-09 - 16-SEP-09. [Details]
(2009)European College of Neuropsychopharmacology, Workshop on Neuropsychopharmacology for Young Scientists in Europe, Nice, France, March 2009,
O’ Mahony. C.M., Bravo, J., Dinan. T.G. and Cryan. J.F (2009) Comparison of stress-induced alterations in hippocampal mGlur7 mRNA in two animal models of depression. [Poster Presentation], European College of Neuropsychopharmacology, Workshop on Neuropsychopharmacology for Young Scientists in Europe, Nice, France, March 2009, Nice , 05-MAR-09 - 08-MAR-09. [Details]
(2009)Digestive Disease Week, Chicago, USA, June 2009,
Clarke G, Fitzgerald P, Hennessy AA, Cassidy EM, Quigley EMM, Ross P, Stanton C, Cryan JF, Dinan TG (2009) Polyunsaturated fatty acids contribute to the inflammatory phenotype in irritable bowel syndrome. [Poster Presentation], Digestive Disease Week, Chicago, USA, June 2009, Chicago , 31-MAY-09 - 03-JUN-09. [Details]
(2009)Neuroscience Ireland, Trinity College Dublin, September 2009,
Browne CA, Clarke, G, Dinan TG, Cryan JF. (2009) Behavioural effects of dietary trypotphan manipulations on c57bl/6j and balb/c mice. [Poster Presentation], Neuroscience Ireland, Trinity College Dublin, September 2009, Dublin , 10-SEP-09 - 11-SEP-09. [Details]
(2008)European Behavioural Pharmacology Society Workshop on Behavioural Genetics and Neuropsychiatric Disorders, Cork, Ireland, September 2008,
Clarke G, O’Mahony SM, Hyland, NP, Fitzgerald P, Cryan JF, Dinan TG (2008) Beta3 adrenoceptor modulation of visceral pain-a possible role for the kynurenine pathway?. [Poster Presentation], European Behavioural Pharmacology Society Workshop on Behavioural Genetics and Neuropsychiatric Disorders, Cork, Ireland, September 2008, Cork , 25-AUG-08 - 27-AUG-08. [Details]
(2008)Irish Society of Gastroenterology, Sligo, Ireland, April 2008,
Clarke, G (2008) Increased tryptophan degradation along the kynurenine pathway in Irritable Bowel Syndrome (IBS)-Evidence of an immune mediated indoleamine 2,3-dioxygenase (IDO) activation in a male cohort. [Invited Oral Presentation], Irish Society of Gastroenterology, Sligo, Ireland, April 2008, Sligo , 24-APR-08 - 25-APR-08. [Details]
(2008)Digestive Disease Week,
Clarke G, Fitzgerald P, Cassidy E, Cryan JF, Quigley EM, Dinan TG; (2008) Altered kynurenine pathway metabolism in Irritable Bowel Syndrome (IBS)-Evidence of indoleamine 2,3-dioxygenase (IDO) activation in a male cohort. [Poster Presentation], Digestive Disease Week, San Diego, USA , 01-MAY-08 - 01-MAY-08. [Details]
(2008)Second Joint International Meeting for Neurogastroenterology and Motility, Lucerne, Switzerland, November 2008,
Clarke G, Fitzgerald P, Cryan JF, Dinan TG. (2008) Increased tryptophan metabolism in irritable bowel syndrome (IBS)–an immune mediated phenomenon?. [Poster Presentation], Second Joint International Meeting for Neurogastroenterology and Motility, Lucerne, Switzerland, November 2008, Lucerne , 06-NOV-08 - 09-NOV-08. [Details]
(2008)Digestive Disease Week, San Diego, USA, May 2008,
Clarke G, Fitzgerald P, Cryan JF, Cassidy EM,Quigley EMM, Dinan TG (2008) Altered kynurenine pathway metabolism in Irritable Bowel Syndrome (IBS)-Evidence of indoleamine 2,3-dioxygenase (IDO) activation in a male cohort. [Poster Presentation], Digestive Disease Week, San Diego, USA, May 2008, San Diego , 17-MAY-08 - 22-MAY-08. [Details]
(2008)European College of Neuropsychopharmacology, Workshop on Neuropsychopharmacology for Young Scientists in Europe, Nice, France, March 2008,
Clarke, G (2008) Evidence of increased tryptophan degradation in psychosis: Simultaneous measurement of tryptophan and its kynurenine pathway metabolites by HPLC. [Invited Oral Presentation], European College of Neuropsychopharmacology, Workshop on Neuropsychopharmacology for Young Scientists in Europe, Nice, France, March 2008, Nice , 06-MAR-08 - 09-MAR-08. [Details]
(2008)Digestive Disease Week, San Diego, USA, May 2008,
Fitzgerald P, Clarke G, Scully P, Cryan JF, Shanahan F, Quigley EMM, Cassidy EM, Dinan TG (2008) Tryptophan catabolism in irritable bowel syndrome: Relationship to cytokines, severity and psychiatric comorbidity. [Poster Presentation], Digestive Disease Week, San Diego, USA, May 2008, San Diego , 17-MAY-08 - 22-MAY-08. [Details]
(2008)International Neuroimmunology Symposium, University College Dublin, Dublin, Ireland, March 2008,
Clarke G, Fitzgerald P, Cryan JF, Cassidy EM,Quigley EMM, Dinan TG (2008) Tryptophan Degradation and Irritable Bowel Syndrome (IBS)-Evidence of an immune mediated indoleamine-2,3-dioxygenase (IDO) activation in a male cohort. [Poster Presentation], International Neuroimmunology Symposium, University College Dublin, Dublin, Ireland, March 2008, Dublin , 13-MAR-08 - 14-MAR-08. [Details]
(2007)European Graduate School of Neuroscience (EURON) workshop, Bad Honnef,November 2007,
Clarke G, Barry S, Scully P, Dinan TG (2007) Simultaneous measurement of tryptophan and its kynurenine pathway metabolites by HPLC: evidence of increased tryptophan degradation in psychosis. [Poster Presentation], European Graduate School of Neuroscience (EURON) workshop, Bad Honnef,November 2007, Bad Honnef , 26-NOV-07 - 29-NOV-07. [Details]
(2007)European College of Neuropsychopharmacology (ECNP), 20th ECNP Congress, Vienna, Austria, September 2007,
O’ Mahony. Cliona M. (2007) Is there a genetic influence on stress –induced changes in the activation of the paraventricular nucleus of the hypothalamus and the prefrontal cortex in the mouse. [Invited Oral Presentation], European College of Neuropsychopharmacology (ECNP), 20th ECNP Congress, Vienna, Austria, September 2007, Vienna , 13-OCT-07 - 17-OCT-07. [Details]
(2007)Brainstorming session, 20th Congress of European College of Neuropsychopharmacology,
Clarke G, Cryan JF, Dinan TG; (2007) An important subplot in the inflammatory theory of depression?. [Poster Presentation], Brainstorming session, 20th Congress of European College of Neuropsychopharmacology, Vienna, Austria , 01-OCT-07 - 01-OCT-07. [Details]
(2006)Neuroscience Ireland, Cork September 2006,
Clarke G, O'Mahony S, Malone G, Dinan TG (2006) Determination of GABA and glutamate in discrete regions of the rodent brain. [Poster Presentation], Neuroscience Ireland, Cork September 2006, Cork , 21-SEP-06 - 22-SEP-06. [Details]
(2004)Collegium Internationale Neuro-Psychopharmacologicum (24th CINP Congress), Paris, France, June 2004,
Stockmeier CA, Shi X, Trojecka A, Clarke G, Konick L, Overholser JC, Jurjus G, Meltzer HY, Friedman L, Rajkowska G (2004) in serotonin-1A receptors in orbitofrontal cortex in depression. [Poster Presentation], Collegium Internationale Neuro-Psychopharmacologicum (24th CINP Congress), Paris, France, June 2004, Paris , 20-JUN-04 - 24-JUN-04. [Details]
(2004)Collegium Internationale Neuro-Psychopharmacologicum (24th CINP Congress), Paris, France, June 2004,
Rajkowska G, Dubey P, Clarke G, Ni Thuairisg S, Mahajan G, Licht C, Van de Werd H, Miguel-Hidalgo JJ, Yuan P, Manji HK, Uylings HB (2004) Glial number is increased in hippocampus but not prefrontal cortex in lithium-treated mice - A stereological study. [Poster Presentation], Collegium Internationale Neuro-Psychopharmacologicum (24th CINP Congress), Paris, France, June 2004, Paris , 20-JUN-04 - 24-JUN-04. [Details]

Committees

 CommitteeFunctionFrom / To
Management Committee, GENIEUR Network Member2013 /
Coordinating Committee, School of Medicine Quality Review Member2013 /

Employment

 EmployerPositionFrom / To
University College Cork Lecturer in Psychiatry01-JUL-12 /
University College Cork Lecturer in Pharmacology01-JAN-12 / 30-JUN-12
University College Cork Research Fellow (Psychiatry)01-OCT-11 / 31-DEC-11
University College Cork Senior Postdoctoral Research Scientist (Alimentary Pharmabiotic Centre)01-MAY-09 / 30-SEP-11
University College Cork Senior Research Scientist (Alimentary Pharmabiotic Centre)01-NOV-06 / 30-APR-09
Neurocure Research Scientist01-NOV-04 / 01-OCT-06
Probiotec Research Scientist01-JUN-04 / 31-JUL-04
3M Pharmaceuticals Research and Development Scientist01-DEC-04 / 01-MAR-04
Pfizer Research Scientist01-OCT-03 / 30-NOV-03
Wyeth Research Scientist01-OCT-01 / 30-SEP-03
University of Mississippi Medical Centre Visiting Research Scientist01-JAN-01 / 30-JUN-01

Education

 YearInstitutionQualificationSubject
2014University College Cork Postgraduate Diploma Teaching & Learning in Higher EducationTeaching and Learning
2013University College Cork Postgraduate Certificate in Teaching and Learning in Higher Ed.Higher Education
2009University College Cork PhDPsychiatry
2001NUI, Galway M.Sc.Neuropharmacology
1999NUI, Galway B.Sc. (Honours)Chemistry

Outreach Activities

 Description

APC Public Forum for World Digestive Health Day May 2014

Symposium: Irritable Bowel Syndrome: Experience of Illness Lewis Glucksman Gallery, March 9th 2013

Debating Science (Judge);Schools Presentation;Discovery Science Exhibition

Journal Activities

 JournalRoleTo / From
Nature Communications Referee01-AUG-14 -
Nature Protocols Referee-
Psychopharmacology Referee-
Psychoneuroendocrinology Referee23-SEP-14 -
Plos One Referee10-JAN-12 -
Brain Behav Immun Referee25-DEC-12 -
Journal Of Affective Disorders Referee02-JAN-13 -
Irish Journal Of Medical Science Referee02-JAN-13 -
Journal Of Gastroenterology And Hepatology Referee01-MAY-13 -
Acta Paediatr Scand Referee01-JAN-14 -
British Journal Of Pharmacology Referee-
Experimental And Molecular Pathology Referee-
Physiology And Behaviour Referee-
Neurochemistry International Referee-
Clin Gastroenterol H Referee01-JAN-14 -
Neuropharmacology Referee-
Journal Of Neuroscience Methods Referee-
Scandinavian Journal Of Gastroenterology Referee-
Progress In Neuro-Psychopharmacology & Biological Psychiatry Referee-
Neuroscience Letters Referee-
Gut Microbes Referee01-AUG-14 -
Nutrients Referee01-AUG-14 -
Benef Microbes Referee31-JUL-14 -

Other Activities

 Description

Grant Reviewer, Medical Research Council UK 2014

Grant Reviewer, French National Research Agency 2014

Grant Reviewer, Netherlands Organisation for Scientific Research (NWO) 2014

Grant Reviewer, Netherlands Organisation for Health Research and Development (ZonMw) TOP programme 2014

Grant Reviewer, Research Grants Council of Hong Kong 2013

 Evaluator, Trans-Domain Proposals, COST 2013

External Examiner, PhD

Internal Examiner for PhD Thesis

Teaching Interests

Current:
BH4005: Psychiatry
MX4090/5090: Research and Professionalism in Medicine
MX3003: Medical Research Project

Previous:
BH4001:Psychiatry and Psychological Medicine
Module Coordinator: PT3445 (Systems Pharmacology)
Module Coordinator: PT4005 (Neuropharmacology)

Contributed to:
PT2447 (Molecular Pharmacology)
PT1445 (Foundation Pharmacology)
PT2201 (Priniciples of Dental Pharmacology)
FM2003 (Foundation of Medicine: Medical Pharmacology)

Recent Postgraduates

 Graduation YearStudent NameInstitutionDegree TypeThesis Title
2014Paul Kennedy University College CorkPHDTowards a Cognitive Neurobiology of Brain-Gut Axis Disorders

Internal Collaborators

 NameInstituteCountry
Prof John F Cryan Department of Anatomy and NeuroscienceIRELAND
Dr Ali Khashan Department of EpidemiologyIRELAND
Prof Fergus Shanahan Department of MedicineIRELAND
Dr Siobhain O'Mahony Department of Anatomy and NeuroscienceIRELAND
Dr Brendan Griffin School of PharmacyIRELAND
Dr Niall Hyland Department of Pharmacology and TherapeuticsIRELAND
Dr Eric Downer Department of Anatomy and NeuroscienceIRELAND
Prof Ted Dinan Department of PsychiatryIRELAND

External Collaborators

 NameOrganisation/ InstitutionCountry
Dr Jana Haase University College DublinIRELAND
Prof Felice Jacka Deakin University, MelbourneAUSTRALIA
Prof Peter Whorwell University of ManchesterUNITED KINGDOM
Dr Beate Niesler University of HeidelbergGERMANY
Dr Hava Golan Ben Gurion UniversityISRAEL
Dr Lieve Desbonnet University of GlasgowSCOTLAND
Prof Eamonn Quigley Houston Methodist Hospital, Houston, TexasU.S.A.