Research Profile

Linda O'Keeffe

Biography

I am a Senior Research Fellow in Epidemiology and I currently hold a Health Research Board (HRB) Emerging Investigator Award (EIA) 2019-2023 [EIA-FA-2019-007 SCaRLeT] at University College Cork. Prior to this, I was recipient of a prestigious UK Medical Research Council (MRC) Fellowship [MR/M014509/1] where I trained in life course and causal inference epidemiology at the University of Bristol from 2014-2019. I completed my PhD research in perinatal and life course epidemiology as a HRB Structured Population and Health-services Research Education (SPHeRE) Scholar from 2010-2014.


Research Grants

 ProjectFunding
Body
Start DateEnd DateAward
Sex Differences in Cardiovascular Risk Accross Lifecourse Transitions.Health Research Board01-AUG-1931-JUL-23€699,546.00
Developing Reporting Guidelines for Clinical Trial Protocols for Trials conducted using Routinely Collected Health Data: the SPIRIT-Routinely Collected Health Data (SPIRIT-RCHD) extensionHealth Research Board€9,888.93
Understanding gender differences in cardiometabolic risk across the life courseMedical Research Council01-AUG-1501-AUG-19€442,976.00
Evidence for Policies to Prevent Chronic Conditions (EPICC)Health Research Board01-MAY-20€250,000.00

Contract Researchers

 Researcher NameProjectRoleFunding Body
Kate O'NeillSex Differences in Cardiovascular Risk Across Life course Transitions (SCaRLeT)Senior Postdoctoral ResearcherHealth Research Board

Publications

Peer Reviewed Journals

 YearPublication
(2020)'Preventive health counselling during antenatal care using the pregnancy risk assessment monitoring system (PRAMS) in Ireland'
Murphy M.;McHugh S.;O'Keeffe L.;Greene R.;Corcoran P.;Kearney P. (2020) 'Preventive health counselling during antenatal care using the pregnancy risk assessment monitoring system (PRAMS) in Ireland'. BMC pregnancy and childbirth, 20 (1) [DOI] [Details]
(2020)'Puberty timing and adiposity change across childhood and adolescence: disentangling cause and consequence'
O'Keeffe LM;Frysz M;Bell JA;Howe LD;Fraser A; (2020) 'Puberty timing and adiposity change across childhood and adolescence: disentangling cause and consequence'. Human Reproduction, 35 (12) [DOI] [Details]
(2020)'The Association Between Preeclampsia and Childhood Development and Behavioural Outcomes'
Maher GM;O'Keeffe GW;O'Keeffe LM;Matvienko-Sikar K;Dalman C;Kearney PM;McCarthy FP;Khashan AS; (2020) 'The Association Between Preeclampsia and Childhood Development and Behavioural Outcomes'. Maternal and child health journal, [DOI] [Details]
(2020)'Sex Differences in the Risk of Coronary Heart Disease Associated With Type 2 Diabetes: A Mendelian Randomization Analysis'
Peters TM;Holmes MV;Richards JB;Palmer T;Forgetta V;Lindgren CM;Asselbergs FW;Nelson CP;Samani NJ;McCarthy MI;Mahajan A;Davey Smith G;Woodward M;O'Keeffe LM;Peters SAE; (2020) 'Sex Differences in the Risk of Coronary Heart Disease Associated With Type 2 Diabetes: A Mendelian Randomization Analysis'. Diabetes Care, [DOI] [Details]
(2020)'Age at period cessation and trajectories of cardiovascular risk factors across mid and later life'
O'Keeffe L.M.;Kuh D.;Fraser A.;Howe L.D.;Lawlor D.;Hardy R. (2020) 'Age at period cessation and trajectories of cardiovascular risk factors across mid and later life'. Heart, [DOI] [Details]
(2019)'Epigenetic gestational age and trajectories of weight and height during childhood: a prospective cohort study'
Bright HD;Howe LD;Khouja JN;Simpkin AJ;Suderman M;O'Keeffe LM; (2019) 'Epigenetic gestational age and trajectories of weight and height during childhood: a prospective cohort study'. Clinical Epigenetics, 11 (1) [DOI] [Details]
(2016)'Positive lifestyle changes around the time of pregnancy: a cross-sectional study'
O'Keeffe LM, Dahly DL, Murphy M, Greene RA, Harrington JM, Corcoran P, Kearney PM. (2016) 'Positive lifestyle changes around the time of pregnancy: a cross-sectional study'. Bmj Open, 6 (5) [Details]
(2015)'Prevalence and predictors of alcohol use during pregnancy: findings from international multicentre cohort studies'
O'Keeffe LM, Kearney PM, McCarthy FP, Khashan AS, Greene RA, North RA, Poston L, McCowan LM, Baker PN, Dekker GA, Walker JJ, Taylor R, Kenny LC. (2015) 'Prevalence and predictors of alcohol use during pregnancy: findings from international multicentre cohort studies'. Bmj Open, 5 (7) [DOI] [Details]
(2014)'The Impact of Mode of Delivery on Childhood Behavioral Outcomes'
Alkhalaf SY, O'Neill SM, O'Keeffe LM, Kenny LC, Khashan AS (2014) 'The Impact of Mode of Delivery on Childhood Behavioral Outcomes'. Reproductive Sciences, 21 (3):196A-196A [DOI] [Details]
(2019)'Data on trajectories of measures of cardiovascular health in the Avon Longitudinal Study of Parents and Children (ALSPAC)'
O'Keeffe LM;Simpkin AJ;Tilling K;Anderson EL;Hughes AD;Lawlor DA;Fraser A;Howe LD; (2019) 'Data on trajectories of measures of cardiovascular health in the Avon Longitudinal Study of Parents and Children (ALSPAC)'. Data In Brief, 23 [DOI] [Details]
(2018)'Smoking as a risk factor for lung cancer in women and men: a systematic review and meta-analysis'
O'Keeffe LM;Taylor G;Huxley RR;Mitchell P;Woodward M;Peters SAE; (2018) 'Smoking as a risk factor for lung cancer in women and men: a systematic review and meta-analysis'. Bmj Open, 8 (10) [DOI] [Details]
(2013)'Surveillance during pregnancy: methods and response rates from a hospital based pilot study of the Pregnancy Risk Assessment Monitoring System in Ireland'
O'Keeffe LM, Kearney PM, Greene RA (2013) 'Surveillance during pregnancy: methods and response rates from a hospital based pilot study of the Pregnancy Risk Assessment Monitoring System in Ireland'. BMC pregnancy and childbirth, 13 [DOI] [Details]
(2018)'Associations of Y chromosomal haplogroups with cardiometabolic risk factors and subclinical vascular measures in males during childhood and adolescence'
O'Keeffe LM;Howe LD;Fraser A;Hughes AD;Wade KH;Anderson EL;Lawlor DA;Erzurumluoglu AM;Davey-Smith G;Rodriguez S;Stergiakouli E; (2018) 'Associations of Y chromosomal haplogroups with cardiometabolic risk factors and subclinical vascular measures in males during childhood and adolescence'. Atherosclerosis, 274 [DOI] [Details]
(2018)'Sex-specific trajectories of measures of cardiovascular health during childhood and adolescence: A prospective cohort study'
O'Keeffe LM;Simpkin AJ;Tilling K;Anderson EL;Hughes AD;Lawlor DA;Fraser A;Howe LD; (2018) 'Sex-specific trajectories of measures of cardiovascular health during childhood and adolescence: A prospective cohort study'. Atherosclerosis, 278 [DOI] [Details]
(2018)'Associations of Body Mass and Fat Indexes With Cardiometabolic Traits'
Bell JA;Carslake D;O'Keeffe LM;Frysz M;Howe LD;Hamer M;Wade KH;Timpson NJ;Davey Smith G; (2018) 'Associations of Body Mass and Fat Indexes With Cardiometabolic Traits'. Journal of The American College of Cardiology, 72 (24) [DOI] [Details]
(2018)'Epigenetic gestational age acceleration: a prospective cohort study investigating associations with familial, sociodemographic and birth characteristics'
Khouja JN;Simpkin AJ;O'Keeffe LM;Wade KH;Houtepen LC;Relton CL;Suderman M;Howe LD; (2018) 'Epigenetic gestational age acceleration: a prospective cohort study investigating associations with familial, sociodemographic and birth characteristics'. Clinical Epigenetics, 10 [DOI] [Details]
(2018)'Mid- and Long-Term Health Risks in Living Kidney Donors: A Systematic Review and Meta-analysis'
O'Keeffe LM;Ramond A;Oliver-Williams C;Willeit P;Paige E;Trotter P;Evans J;Wadström J;Nicholson M;Collett D;Di Angelantonio E; (2018) 'Mid- and Long-Term Health Risks in Living Kidney Donors: A Systematic Review and Meta-analysis'. Annals of Internal Medicine, 168 (4) [DOI] [Details]
(2018)'Environmental toxic metal contaminants and risk of cardiovascular disease: systematic review and meta-analysis'
Chowdhury R;Ramond A;O'Keeffe LM;Shahzad S;Kunutsor SK;Muka T;Gregson J;Willeit P;Warnakula S;Khan H;Chowdhury S;Gobin R;Franco OH;Di Angelantonio E; (2018) 'Environmental toxic metal contaminants and risk of cardiovascular disease: systematic review and meta-analysis'. BMJ (Clinical Research Ed.), 362 [DOI] [Details]
(2016)'Body-mass index and all-cause mortality: individual-participant-data meta-analysis of 239 prospective studies in four continents'
Global BMI Mortality Collaboration ;Di Angelantonio E;Bhupathiraju ShN;Wormser D;Gao P;Kaptoge S;Berrington de Gonzalez A;Cairns BJ;Huxley R;Jackson ChL;Joshy G;Lewington S;Manson JE;Murphy N;Patel AV;Samet JM;Woodward M;Zheng W;Zhou M;Bansal N;Barricarte A;Carter B;Cerhan JR;Smith GD;Fang X;Franco OH;Green J;Halsey J;Hildebrand JS;Jung KJ;Korda RJ;McLerran DF;Moore SC;O'Keeffe LM;Paige E;Ramond A;Reeves GK;Rolland B;Sacerdote C;Sattar N;Sofianopoulou E;Stevens J;Thun M;Ueshima H;Yang L;Yun YD;Willeit P;Banks E;Beral V;Chen Zh;Gapstur SM;Gunter MJ;Hartge P;Jee SH;Lam TH;Peto R;Potter JD;Willett WC;Thompson SG;Danesh J;Hu FB; (2016) 'Body-mass index and all-cause mortality: individual-participant-data meta-analysis of 239 prospective studies in four continents'. The Lancet, 388 (10046) [DOI] [Details]
(2015)'The impact of obstetric mode of delivery on childhood behavior'
O'Keeffe LM, Henriksen TB, Kenny LC, Cryan JF, Khashan AS, Khalaf SY, O'Neill SM (2015) 'The impact of obstetric mode of delivery on childhood behavior'. Social psychiatry and psychiatric epidemiology, [DOI] [Details]
(2015)'Association of Cardiometabolic Multimorbidity With Mortality'
;Di Angelantonio E;Kaptoge S;Wormser D;Willeit P;Butterworth AS;Bansal N;O'Keeffe LM;Gao P;Wood AM;Burgess S;Freitag DF;Pennells L;Peters SA;Hart CL;Håheim LL;Gillum RF;Nordestgaard BG;Psaty BM;Yeap BB;Knuiman MW;Nietert PJ;Kauhanen J;Salonen JT;Kuller LH;Simons LA;van der Schouw YT;Barrett-Connor E;Selmer R;Crespo CJ;Rodriguez B;Verschuren WM;Salomaa V;Svärdsudd K;van der Harst P;Björkelund C;Wilhelmsen L;Wallace RB;Brenner H;Amouyel P;Barr EL;Iso H;Onat A;Trevisan M;D'Agostino RB;Cooper C;Kavousi M;Welin L;Roussel R;Hu FB;Sato S;Davidson KW;Howard BV;Leening MJ;Leening M;Rosengren A;Dörr M;Deeg DJ;Kiechl S;Stehouwer CD;Nissinen A;Giampaoli S;Donfrancesco C;Kromhout D;Price JF;Peters A;Meade TW;Casiglia E;Lawlor DA;Gallacher J;Nagel D;Franco OH;Assmann G;Dagenais GR;Jukema JW;Sundström J;Woodward M;Brunner EJ;Khaw KT;Wareham NJ;Whitsel EA;Njølstad I;Hedblad B;Wassertheil-Smoller S;Engström G;Rosamond WD;Selvin E;Sattar N;Thompson SG;Danesh J; (2015) 'Association of Cardiometabolic Multimorbidity With Mortality'. Jama-Journal Of The American Medical Association, 314 (1) [DOI] [Details]
(2015)'Maternal alcohol use during pregnancy and offspring trajectories of height and weight: A prospective cohort study'
O'Keeffe, LM;Kearney, PM;Greene, RA;Zuccolo, L;Tilling, K;Lawlor, DA;Howe, LD (2015) 'Maternal alcohol use during pregnancy and offspring trajectories of height and weight: A prospective cohort study'. Drug and alcohol dependence, 153 :323-329 [DOI] [Details]
(2015)'Prevalence and predictors of alcohol use during pregnancy: findings from international multicentre cohort studies'
O'Keeffe, LM;Kearney, PM;McCarthy, FP;Khashan, AS;Greene, RA;North, RA;Poston, L;McCowan, LME;Baker, PN;Dekker, GA;Walker, JJ;Taylor, R;Kenny, LC (2015) 'Prevalence and predictors of alcohol use during pregnancy: findings from international multicentre cohort studies'. Bmj Open, 5 [DOI] [Details]
(2014)'Pregnancy Risk Assessment Monitoring System in Ireland: Methods and Response Rates'
O'Keeffe LM, Kearney PM, Greene RA (2014) 'Pregnancy Risk Assessment Monitoring System in Ireland: Methods and Response Rates'. Maternal and child health journal, [DOI] [Details]
(2014)'The effect of moderate gestational alcohol consumption during pregnancy on speech and language outcomes in children: a systematic review'
O'Keeffe LM, Greene RA, Kearney PM (2014) 'The effect of moderate gestational alcohol consumption during pregnancy on speech and language outcomes in children: a systematic review'. Systematic reviews, 3 [DOI] [Full Text] [Details]
(2013)'Association Between Maternal Alcohol Consumption in Early Pregnancy and Pregnancy Outcomes'
McCarthy, FP;O'Keeffe, LM;Khashan, AS;North, RA;Poston, L;McCowan, LME;Baker, PN;Dekker, GA;Roberts, CT;Walker, JJ;Kenny, LC (2013) 'Association Between Maternal Alcohol Consumption in Early Pregnancy and Pregnancy Outcomes'. Obstetrics and Gynecology, 122 :830-837 [DOI] [Details]

Conference Publications

 YearPublication
(2014)Late initiation of antenatal care in a large urban hospital: data from the Pregnancy Risk Assessment Monitoring System
MC HUGH, S., O’KEEFFE, L., CORCORAN, P., GREENE, R. & KEARNEY, P (2014) Journal of Epidemiology and Community Health Late initiation of antenatal care in a large urban hospital: data from the Pregnancy Risk Assessment Monitoring System   [DOI] [Details]

Abstract

 YearPublication
(2014)The Impact of Mode of Delivery on Childhood Behavioral Outcomes.
Alkhalaf, SY;O'Neill, SM;O'Keeffe, LM;Kenny, LC;Khashan, AS (2014) The Impact of Mode of Delivery on Childhood Behavioral Outcomes. THOUSAND OAKS: Abstract [DOI] [Details]
(2014)Early Term Birth & Risk of Behavioral Problems in Infancy.
Ogbodo, EI;O'Keeffe, LM;O'Neill, SM;Kenny, LC;Khashan, AS (2014) Early Term Birth & Risk of Behavioral Problems in Infancy. THOUSAND OAKS: Abstract [Details]
(2014)Maternal Alcohol Use during Pregnancy and Offspring Trajectories of Height and Weight: A Prospective Cohort Study.
O'Keeffe, LM,Kearney, PM,Greene, RA,Zuccolo, L,Tilling, K,Lawlor, DA,Howe, LD (2014) Maternal Alcohol Use during Pregnancy and Offspring Trajectories of Height and Weight: A Prospective Cohort Study. Abstract [Details]
(2013)Systematic Review of the Effects of Low to Moderate Alcohol Consumption during Pregnancy and Speech and Language Development in Infants.
O'Keeffe, LM,Greene, RA,Kearney, PM (2013) Systematic Review of the Effects of Low to Moderate Alcohol Consumption during Pregnancy and Speech and Language Development in Infants. Abstract [Details]
(2013)Moderate Alcohol Consumption in Early, Middle and Late Pregnancy and Small for Gestational Age, Preterm Birth and Birth Weight: A Retrospective Cohort Study.
O'Keeffe, LM,Daly, G,Kearney, PM,Greene, RA (2013) Moderate Alcohol Consumption in Early, Middle and Late Pregnancy and Small for Gestational Age, Preterm Birth and Birth Weight: A Retrospective Cohort Study. Abstract [Details]

Articles

 YearPublication
(2020)Mitochondrial DNA haplogroups and trajectories of cardiometabolic risk factors during childhood and adolescence: a prospective cohort study.
O'Neill, K N and Aubrey, E and Howe, L D and Stergiakouli, E and Rodriguez, S and Kearney, P M and O'Keeffe, L M (2020) Mitochondrial DNA haplogroups and trajectories of cardiometabolic risk factors during childhood and adolescence: a prospective cohort study. Articles [DOI] [Details]

Reviews

 YearPublication
(2016)Alcohol use during pregnancy.
O'Keeffe L.;Kearney P.;Greene R.;Kenny L. (2016) Alcohol use during pregnancy. Reviews [DOI] [Details]

Professional Activities

Conference Contributions

 YearPublication
(2014)UK Society for Social Medicine Annual Meeting,
MC HUGH, S., O’KEEFFE, L., CORCORAN, P., GREENE, R. & KEARNEY, P (2014) Late initiation of antenatal care in a large urban hospital: data from the Pregnancy Risk Assessment Monitoring Syste. [Oral Presentation], UK Society for Social Medicine Annual Meeting, Oxford, United Kingdom . [Details]
(2014)61st Annual Meeting of the Society for Gynecological Investigation,
Alkhalaf, SY,O'Neill, SM,O'Keeffe, LM,Kenny, LC,Khashan, AS (2014) The Impact of Mode of Delivery on Childhood Behavioral Outcomes. [Poster Presentation], 61st Annual Meeting of the Society for Gynecological Investigation, Florence, Italy . [Details]
(2014)61st Annual Meeting of the Society for Gynecological Investigation,
Ogbodo, EI,O'Keeffe, LM,O'Neill, SM,Kenny, LC,Khashan, AS (2014) Early Term Birth & Risk of Behavioral Problems in Infancy. [Poster Presentation], 61st Annual Meeting of the Society for Gynecological Investigation, Florence, Italy . [Details]
(2013)60th Annual Meeting of the Society for Gynecological Investigation,
McCarthy, FP,O'Keeffe, LM,Khashan, AS,North, RA,Walker, JJ,Baker, PN,Dekker, G,Poston, L,McCowan, LME,Kenny, LC,SCOPE Consortium (2013) The Impact of Maternal Alcohol Consumption on Pregnancy Outcomes. [Poster Presentation], 60th Annual Meeting of the Society for Gynecological Investigation, Orlando, USA . [Details]
(2011)UCC College of Medicine & Health Annual Research Conference,
O'Keeffe L, Lutomski JE, Van Lente E, Kearney P, Greene RA; (2011) Today's babies are Ireland's future: A population-based surveillance system of maternal experiences and behaviours before, during and after pregnancy. [Poster Presentation], UCC College of Medicine & Health Annual Research Conference, Brookfield Health Sciences Complex, College Road, UCC, Cork , 22-JUN-11 - 22-JUN-11. [Details]

Employment

 EmployerPositionFrom / To
University of Bristol Research Fellow01-AUG-15 / 01-SEP-19
University of Cambridge Research Associate01-AUG-14 / 01-AUG-15

Education

 YearInstitutionQualificationSubject
2010University College Cork BScPublic Health
2014University College Cork PhDEpidemiology

Journal Activities

 JournalRoleTo / From
Bmj (Clinical Research Ed.) Referee-

Teaching Activities

Recent Postgraduates

 Graduation YearStudent NameInstitutionDegree TypeThesis Title
2020Minhal Ahmed NUI (UCC)MPHSex differences in the association of socioeconomic position with trajectories of cardiovascular risk factors across early life
2019Lisa Ryan NUI (UCC)Puberty timing and cardiovascular risk during adolescence

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