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Biography

Dr Patrick Forde BSc, PhD.
Principal Investigator at the CancerResearch@UCC  where I head a research focused team developing physical and immune-based therapies. 








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Research Interests

- immunogenic control of cancer
- novel cancer therapies
- Physical therapies
- Gene and drug delivery

Research Grants

	Project	Funding Body	Start Date	End Date	Award
	Harnessing the immune system to target primary and secondary pancreatic cancer	Other: Not Listed	30-NOV-14	01-NOV-17	€240,000.56
	Combining electrotherapy with a toll like receptor agonist for the treatment of lung cancer	Health Research Board	31-DEC-18	13-JAN-22	€158,293.00
	Breakthrough Cancer Research - Pancreatic Cancer: Stemness & Resistance to Treatments such as Electroporation / Electrochemotherapy	Irish Funded Research	01-NOV-17	31-OCT-18	€24,000.00
	lung electrochemotherapy and immunotherapy	Medical Research Council	16-JAN-19	15-JAN-22	€158,293.00
	Harnessing the immune system to target primary and secondary pancreatic cancer.	Foreign Research Institute	02-APR-15	22-AUG-19	€227,036.00
	Making Therapy more effective for Pancreatic Cancer using Electrochemotherapy	Irish Funded Research Non Exchequer	01-JUN-18	30-NOV-20	€78,713.00
	Novartis C&CRA 2018/027 (via CUF): Retrospective Analysis Examining the Effect of Macrophages & Gene Expression on Patient Responses to Treatment for Melanoma	Foundation Funded Research	09-JAN-18	30-NOV-19	€16,000.00
	Cancers of Poor Prognosis: Immunogenic Pathways	Irish Funded Research Non Exchequer	01-MAY-18	30-APR-20	€78,540.00
	Osteosarcoma- Combination of Electroporation of Metabolic Modulcators with Low Dose Chemotherapy.	Irish Funded Research	01-DEC-17	30-NOV-18	€17,770.00

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Publications

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Book Chapters

	Year	Publication
	(2018)	'Biomaterial-Mediated Drug Delivery in Primary and Metastatic Cancers of the Bone' Patrick F. Forde and Katie B. Ryan (2018) 'Biomaterial-Mediated Drug Delivery in Primary and Metastatic Cancers of the Bone' In: Li, Bingyun, Webster, Thomas (Eds.) (eds). Orthopedic Biomaterials. USA: Springer. [Details]
	(2011)	'Clinical application of electrochemotherapy - An adjunct to surgery' Soden D.;Sadadcharam M.;Forde P.;O'Sullivan G. (2011) 'Clinical application of electrochemotherapy - An adjunct to surgery' In: Electroporation in Laboratory and Clinical Investigations. [Details]
	(2011)	'Minimally Invasive Intraluminal Tumor Ablation' Patrick F. Forde, Michael G. Bourke, Slawomir Salwa, Gerald C. O’Sullivan, Declan M. Soden: (2011) 'Minimally Invasive Intraluminal Tumor Ablation' In: Clinical aspects of Electroporation. New York: Springer-Verlag New York. [Details]
	(2011)	'Clinical Application of Electrochemotherapy – An Adjunct to Surgery Clinical Aspects of Eletroporation' Mira Sadadcharam, Patrick Forde, Declan M Soden, Gerald C O’ Sullivan (2011) 'Clinical Application of Electrochemotherapy – An Adjunct to Surgery Clinical Aspects of Eletroporation' In: Electroporation in Laboratory and Clinical Investigations. US: novapublishers. [Details]
	(2010)	'Combined Electrical Field and Ultrasound' Patrick F Forde, Ciara Twomey, Gerald C O'Sullivan, Declan M Soden (2010) 'Combined Electrical Field and Ultrasound' In: Advanced Electroporation Techniques in Biology and Medicine. US: CRC Press. [Details]

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Peer Reviewed Journals

	Year	Publication
	(2020)	'Electrochemotherapy for colorectal cancer using endoscopic electroporation: a phase 1 clinical study' Hansen, HF;Bourke, M;Stigaard, T;Clover, J;Buckley, M;O'Riordain, M;Winter, D;Johannesen, HH;Hansen, RH;Heeboll, H;Forde, P;Jakobsen, HL;Larsen, O;Rosenberg, J;Soden, D;Gehl, J (2020) 'Electrochemotherapy for colorectal cancer using endoscopic electroporation: a phase 1 clinical study'. Endoscopy International Open, 8 :124-132 [DOI] [Details]
	(2019)	'Melanoma-conditioned medium promotes cytotoxic immune responses by murine bone marrow-derived monocytes despite their expression of ‘M2’ markers' Tremble L.;Moore A.;Forde P. (2019) 'Melanoma-conditioned medium promotes cytotoxic immune responses by murine bone marrow-derived monocytes despite their expression of ‘M2’ markers'. Cancer Immunology Immunotherapy, [DOI] [Details]
	(2019)	'Electrochemotherapy causes caspase-independent necrotic-like death in pancreatic cancer cells' Fernandes P.;O’Donovan T.;McKenna S.;Forde P. (2019) 'Electrochemotherapy causes caspase-independent necrotic-like death in pancreatic cancer cells'. Cancers, 11 (8) [DOI] [Details]
	(2018)	'ICOS activation in combination with electrochemotherapy generates effective anti-cancer immunological responses in murine models of primary, secondary and metastatic disease' Tremble, LF;O'Brien, MA;Forde, PF;Soden, DM (2018) 'ICOS activation in combination with electrochemotherapy generates effective anti-cancer immunological responses in murine models of primary, secondary and metastatic disease'. Cancer Letters, 420 :109-115 [DOI] [Details]
	(2018)	'ICOS activation in combination with electrochemotherapy generates effective anti-cancer immunological responses in murine models of primary, secondary and metastatic disease' Liam F. Tremble, Morgan A. O'Brien, Patrick F.Forde, Declan M.Soden (2018) 'ICOS activation in combination with electrochemotherapy generates effective anti-cancer immunological responses in murine models of primary, secondary and metastatic disease'. Cancer Letters, 420 :109-115 [DOI] [Details]
	(2015)	'Low immunogenicity in non-small cell lung cancer; do new developments and novel treatments have a role?' Gardiner R.;Jahangeer S.;Forde P.;Ariffin A.;Bird B.;Soden D.;Hinchion J. (2015) 'Low immunogenicity in non-small cell lung cancer; do new developments and novel treatments have a role?'. Cancer And Metastasis Reviews, 34 (1):129-144 [DOI] [Details]
	(2018)	'Electrochemotherapy with cisplatin increases survival and induces immunogenic responses in murine models of lung cancer and colorectal cancer' Tremble LF;O'Brien MA;Forde PF; (2018) 'Electrochemotherapy with cisplatin increases survival and induces immunogenic responses in murine models of lung cancer and colorectal cancer'. Cancer Letters, [DOI] [Details]
	(2018)	'Combination of electroporation delivered metabolic modulators with low-dose chemotherapy in Osteosarcoma' KS. Gill, P Fernandes, B Bird, Declan M. Soden, Patrick F. Forde (2018) 'Combination of electroporation delivered metabolic modulators with low-dose chemotherapy in Osteosarcoma'. Oncotarget, 59 (9):31473-31489 [DOI] [Details]
	(2018)	'Expressional changes in stemness markers post electrochemotherapy in pancreatic cancer cells' Ali, Shahzad; Gill, Kheshwant S.; Saglio. Giuseppe; Cilloni, Daniela; Soden, Declan M.; Forde, Patrick F. (2018) 'Expressional changes in stemness markers post electrochemotherapy in pancreatic cancer cells'. Bioelectrochemistry,   [DOI] [Full Text] [Details]
	(2016)	'Preclinical evaluation of an endoscopic electroporation system' Patrick F Forde, Mira Sadadcharam, Michael G Bourke, Thomas A Conway, Shane R Gurein, Marcel de Kruijf, Gerald O' Sullivan, Joseph Impellizeri, Anthony James P Clover, Declan M Soden (2016) 'Preclinical evaluation of an endoscopic electroporation system'. Endoscopy, [Details]
	(2016)	'Glycolysis inhibition as a cancer treatment and its role in an anti-tumour immune response' Kheswant S Gill, Philana Fernades, Tracey R O' Donovan, Sharon L Mckenna, Kishore K Daddakula, Derek G Power, Declan M Soden, Patrick F Forde (2016) 'Glycolysis inhibition as a cancer treatment and its role in an anti-tumour immune response'. BBA Biochimica et Biophysica Acta, [Details]
	(2016)	'Antitumour responses induced by a cell-based Reovirus vaccine in murine lung and melanoma models' Ciorsdan Campion, Declan M Soden, Patrick F Forde (2016) 'Antitumour responses induced by a cell-based Reovirus vaccine in murine lung and melanoma models'. BMC Cancer, 16 (1) [Details]
	(2015)	'Successful Management of an Occult Cardiac Tamponade with Prompt Surgical Intervention and a Novel, Defined Pericardial Irrigation Protocol' Saleem Janheer, Rebecca E Gardiner, Patrcik Fode, John Hinchion (2015) 'Successful Management of an Occult Cardiac Tamponade with Prompt Surgical Intervention and a Novel, Defined Pericardial Irrigation Protocol'. Journal Of Thoracic And Cardiovascular Surgery, [Details]
	(2015)	'Low immunogenicity in non-small cell lung cancer; do new developments and novel treatments have a role?' Rebecca E Gardiner, Saleem Jahangeer, Patrick F Forde, Arlizan B Ariffin, Brian Bird, Declan M Soden, John Hinchion (2015) 'Low immunogenicity in non-small cell lung cancer; do new developments and novel treatments have a role?'. SpringerPlus, 34 (1):129-144 [Details]
	(2014)	'Enhancement of electroporation facilitated immunogene therapy via T-reg depletion' Patrick F Forde, Mira Sadadcharam, Tracey R O’Donovan, Lindsay J Hall, Marcel de Kruijf, William L Byrne, Gerald C O’Sullivan, Declan M. Soden. (2014) 'Enhancement of electroporation facilitated immunogene therapy via T-reg depletion'. Cancer Gene Therapy, [Details]
	(2014)	'Development and characterization of an enhanced nonviral expression vector for electroporation cancer treatment' Patrick F. Forde, Lindsay J. Hall, Mira Sadadcharam, Marcle de Kruijf, Gerald C. O’Sullivan, Declan M. Soden (2014) 'Development and characterization of an enhanced nonviral expression vector for electroporation cancer treatment'. Molecular Therapy, [Details]
	(2014)	'Releasing Pressure in Tumors: What Do We Know So Far and Where Do We Go from Here? A Review' Arlizan B Ariffin, Patrick F Forde, Saleem Jahangeer, Declan M Soden, John Hinchion (2014) 'Releasing Pressure in Tumors: What Do We Know So Far and Where Do We Go from Here? A Review'. Cancer Research, [Details]
	(2014)	'Non-viral immune electrogene therapy induces potent antitumour responses and has a curative effect in murine colon adenocarcinoma and melanoma cancer models' Patrick F Forde, Lindsay J Hall, Marcel de Kruijf, M G Bourke, Timothy Doddy, M Sadadcharam, Declan M. Soden. (2014) 'Non-viral immune electrogene therapy induces potent antitumour responses and has a curative effect in murine colon adenocarcinoma and melanoma cancer models'. Cancer Gene Therapy, [Details]
	(2014)	'Tumour Ablative Therapies: Opportunities for Maximising Immune Engagement and Activation' Morgan A. O’Brien, Derek G. Power, A. James P. Clover, Brian Bird, Declan M. Soden, Patrick F. Forde. (2014) 'Tumour Ablative Therapies: Opportunities for Maximising Immune Engagement and Activation'. BBA Biochimica et Biophysica Acta, [Details]
	(2013)	'Electrochemotherapy for the treatment of ocular basal cell carcinoma; a novel adjunct in the disease management' S P Salwa, M G Bourke, P F Forde, M O'Shaughnessy, S T O'Sullivan, E J Kelly, D M Soden, A J P Clover (2013) 'Electrochemotherapy for the treatment of ocular basal cell carcinoma; a novel adjunct in the disease management'. British Journal of Plastic Surgery, [Details]
	(2011)	'The emerging role of viruses in the treatment of solid tumours' Bourke, M. G.,Salwa, S.,Harrington, K. J.,Kucharczyk, M. J.,Forde, P. F.,de Kruijf, M.,Soden, D.,Tangney, M.,Collins, J. K.,O'Sullivan, G. C.; (2011) 'The emerging role of viruses in the treatment of solid tumours'. Cancer Treat Rev,   [Details]
	(2011)	'The emerging role of viruses in the treatment of solid tumours.. Cancer Treatment Reviews' M G Bourke, S Salwa, K J Harrington, M J Kucharczyk, P F Forde, M de Kruijf, D Soden, M Tangney, J K Collins, G C O'Sullivan (2011) 'The emerging role of viruses in the treatment of solid tumours.. Cancer Treatment Reviews'. Cancer Treatment Reviews, [Details]

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Conference Publications

	Year	Publication
	(2020)	European Journal of Surgical Oncology Clover A.J.P.;Salwa S.P.;Bourke M.G.;McKiernan J.;Forde P.F.;O'Sullivan S.T.;Kelly E.J.;Soden D.M. (2020) Electrochemotherapy for the treatment of primary basal cell carcinoma; A randomised control trial comparing electrochemotherapy and surgery with five year follow up European Journal of Surgical Oncology , pp.847-854 [DOI] [Details]

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Abstract

	Year	Publication
	(2020)	Calcium electroporation offers an effective local treatment with immunogenic cell death and the potential for systemic remission in melanoma. Tremble, LF;Heffron, C;Forde, P (2020) Calcium electroporation offers an effective local treatment with immunogenic cell death and the potential for systemic remission in melanoma. PHILADELPHIA: Abstract [Details]
	(2019)	Correlating macrophage infiltration with BRAF status and prognostic features in melanoma using immunohistochemistry. Mc Cabe, M;Tremble, LF;Werner, R;Tynan, R;Forde, P;Heffron, C (2019) Correlating macrophage infiltration with BRAF status and prognostic features in melanoma using immunohistochemistry. NEW YORK: Abstract [Details]
	(2016)	Polymorphisms in TPMT and TYMS may predict severe toxicity in DPYD wild-type patients receiving fluoropyrimidine (FP) chemotherapy for colorectal cancer. Peoples, AM;Ahmed, G;Galiauskas, R;Sullivan, R;Forde, P;Varughese, P;Sathyan, P;Amaral-Trusty, E;McGrath, L;Rosenblatt, KP;Dehghani, M;Floyd, KC;Bird, BR;Murphy, CG (2016) Polymorphisms in TPMT and TYMS may predict severe toxicity in DPYD wild-type patients receiving fluoropyrimidine (FP) chemotherapy for colorectal cancer. ALEXANDRIA: Abstract [DOI] [Details]
	(2013)	Pre-clinical validationof electrochemotherapy (ECT) in the treatment of lung tumours. Jahangeer, S,Forde, P,Soden, D,Hinchion, J (2013) Pre-clinical validationof electrochemotherapy (ECT) in the treatment of lung tumours. Abstract [Details]
	(2013)	PRE-CLINICAL VALIDATION OF ELECTROCHEMOTHERAPY (ECT) IN THE TREATMENT OF LUNG TUMOURS. Jahangeer, S;Forde, P;Soden, D;Hinchion, J (2013) PRE-CLINICAL VALIDATION OF ELECTROCHEMOTHERAPY (ECT) IN THE TREATMENT OF LUNG TUMOURS. PHILADELPHIA: Abstract [Details]
	(2012)	Reconditioning the Tumour Microenvironment with Immunogene Therapy Suppresses Tumour Development and Progression. Bourke, MG;Forde, P;de Kruijf, M;O'Donovan, T;Casey, G;Soden, DM;O'Sullivan, GC (2012) Reconditioning the Tumour Microenvironment with Immunogene Therapy Suppresses Tumour Development and Progression. LONDON: Abstract [Details]
	(2012)	Lentiviral-mediated cell-specific RNA interference in regulatory T cells. Byrne, WL;Forde, P;O'Sullivan, G (2012) Lentiviral-mediated cell-specific RNA interference in regulatory T cells. PHILADELPHIA: Abstract [DOI] [Details]
	(2010)	DEVELOPMENT OF AN ENDOSCOPICALLY DELIVERED ABLATIVE TREATMENT FOR GASTROINTESTINAL TUMOURS. Bourke, MG;Salwa, S;Sadadcharam, M;Forde, P;O'Sullivan, GC;Soden, D (2010) DEVELOPMENT OF AN ENDOSCOPICALLY DELIVERED ABLATIVE TREATMENT FOR GASTROINTESTINAL TUMOURS. LONDON: Abstract [Details]
	(2012)	Reconditioning the Tumour Microenvironment with Immunogene Therapy Suppresses Tumour Development and Progression. Bourke, MG,Forde, P,de Kruijf, M,O'Donovan, T,Casey, G,Soden, DM,O'Sullivan, GC (2012) Reconditioning the Tumour Microenvironment with Immunogene Therapy Suppresses Tumour Development and Progression. Abstract [Details]
	(2010)	DEVELOPMENT OF AN ENDOSCOPICALLY DELIVERED ABLATIVE TREATMENT FOR GASTROINTESTINAL TUMOURS. Bourke, MG,Salwa, S,Sadadcharam, M,Forde, P,O'Sullivan, GC,Soden, D (2010) DEVELOPMENT OF AN ENDOSCOPICALLY DELIVERED ABLATIVE TREATMENT FOR GASTROINTESTINAL TUMOURS. Abstract [Details]

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Reviews

	Year	Publication
	(2020)	The pentose phosphate pathway dynamics in cancer and its dependency on intracellular pH. Alfarouk K.O.;Ahmed S.B.M.;Elliott R.L.;Benoit A.;Alqahtani S.S.;Ibrahim M.E.;Bashir A.H.H.;Alhoufie S.T.S.;Elhassan G.O.;Wales C.C.;Schwartz L.H.;Ali H.S.;Ahmed A.;Forde P.F.;Devesa J.;Cardone R.A.;Fais S.;Harguindey S.;Reshkin S.J. (2020) The pentose phosphate pathway dynamics in cancer and its dependency on intracellular pH. Reviews [DOI] [Details]
	(2016)	Electroporation in veterinary oncology. Impellizeri, J;Aurisicchio, L;Forde, P;Soden, DM (2016) Electroporation in veterinary oncology. OXFORD: Reviews [DOI] [Details]
	(2015)	Low immunogenicity in non-small cell lung cancer; do new developments and novel treatments have a role?. Gardiner, RE;Jahangeer, S;Forde, P;Ariffin, AB;Bird, B;Soden, D;Hinchion, J (2015) Low immunogenicity in non-small cell lung cancer; do new developments and novel treatments have a role?. DORDRECHT: Reviews [DOI] [Details]
	(2013)	Review of current thermal ablation treatment for lung cancer and the potential of electrochemotherapy as a means for treatment of lung tumours. Jahangeer, S;Forde, P;Soden, D;Hinchion, J (2013) Review of current thermal ablation treatment for lung cancer and the potential of electrochemotherapy as a means for treatment of lung tumours. OXFORD: Reviews [DOI] [Details]

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Professional Activities

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Honours and Awards

	Year	Title	Awarding Body
	2014	Pancreatic Cancer Research Fund, UK	Pancreatic Cancer Research Fund, UK
	2014	Pfizer Award for Innovation through Teamwork	Pfizer Award for Innovation through Teamwork

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Other Activities

	Description
	Completed Professional Skills for Research Leaders online programme in 2016. Received Certificate Institute of Leadership and Management

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Teaching Activities

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Teaching Interests

Research-led Teaching

Teaching and supervision through research undergraduate and postgraduate students (PhD, MD, MSc)  
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Recent Postgraduates

	Graduation Year	Student Name	Institution	Degree Type	Thesis Title
	2015	Arlizan B Ariffin	University College Cork	MD	Tumour interstitial pressure and its modulation
	2020	Liam Friel Tremble	University College Cork	PHD	The characterisation of macrophages in melanoma and the effect of electroporation on melanoma conditioned macrophages
	2016	Mira Sadadcharam	University College Cork	PHD
	2016	Morgan A O' Brien	University College Cork	PhD	Immunotherapy for the treatment of poor prognosis cancers

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Current Postgraduate Students

	Student	Degree Type
	Cooke Katie Deniese	Masters Degree by Research
	Bendix Maura Bettina Susanne	Doctoral Degree