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A Pharmacologist and veterinarian with ten years of research and clinical experience in preclinical pharmacology, vascular and cardiovascular research, microsurgery, preclinical imaging, regenerative medicine, rodent colony management and cell biology. Adaptable, creative and enthusiastic scientist with leadership skills to direct and develop productive team in basic and applied research.

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Research Interests

Preclinical pharmacology, vascular and cardiovascular disease research, microsurgery, preclinical imaging, regenerative medicine and cell biology. 

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Research Techniques

Vascular, cardiovascular and neurovascular functional phenotyping as part of preclinical and safety pharmacology.

Imaging: Intravital, fluoroscopy, multiphoton, confocal microscopy, CT-PET, SEM.

Preclinical drug discovery: GLP based In vivo and in vitro pharmacodynamic and pharmacokinetic studies.

Developing rodent and porcine models of vascular and myocardial remodelling.

Creating animal models of diabetes, hypertension and inflammation.

Expertise in 2D and 3D Image analysis (IMARIS software).

Single cell functional phenotyping (Endothelial and smooth muscle progenitor cells, cardiomyocytes, monocytes, macrophages, smooth muscle and endothelial cell primary cultures and established cell lines).

Pathological, histopathological, immunohistochemistry and biochemical techniques.

Rodent and porcine colony management.

Statistical evaluation of biological data.

Project management skills

Have independently/as team member managed the following research projects:

Role of Progenitor cells in cardiovascular pathophysiology.

Cardio protective effects of low dose IGF1 .

CX3CR1 cytokine network in restenosis and plaque angiogenesis.

Developing next generations of cytokine eluting stents.

Developing progenitor cells/secreted factors for treating burn wounds.

Studies on the role of NADPH Oxidases and soluble Guanylyl Cyclases in cardiovascular/vascular/neurological pathophysiology. (Postdoc).

Studies on the role of calcium channels on angiotensin responses in diabetic rat vasculature (Ph.D. Thesis).

Studies on the role of antioxidants in combating salinomycin and maduramycin toxicity in broiler chicks (M.V.Sc Thesis).

Role of oxidative stress in enhanced vascular and nonvascular contractions in diabetic rats.

Acute hyperglycemic effects induced changes in motor nerve conduction velocity and nerve blood flow: Identifying the mechanisms involved.

Role of oxidative stress and adenosinergic receptors in diabetic neuropathy.

Advanced glycation end product breakers in combating type I & II diabetic vascular complications. (Industrial Project).

Dipeptidyl peptidase IV inhibitors in therapy of type II diabetes. (Industrial Project).

Screening of novel diclofenac formulations for their analgesic and anti-inflammatory activity in rodent model. (Industrial Project).

Grants/Fellowships

Science Foundation Ireland-TIDA Entrepreneurship award. Arun HS Kumar. (2011-2012)

British Burns Association Research Grant. James Clover and Arun HS Kumar. Application of circulating progenitor cells on the burn wound to enhance the rate of burn wound healing. (2010-2011).

Enterprise Ireland. Development of IGF1 stent. Noel M Caplice and Arun HS Kumar. (2010-2011).

Irish Heart Foundation. Cardiac Angiogenesis: ‘Cell based bypass’ of chronic vascular occlusions. Brian G Hynes and Arun Kumar HS. (2007-2009).

NHMRC Grant (384163), Australia. Defining the role of NADPH oxidases in vascular remodelling and arterial hypertension. Grant Drummond, Arun Kumar HS, Harald HHW Schmidt, Chris Sobby and Robert Widdop. (2006 to 2008).

Senior Research Fellowship, CSIR, India. Studies on the role of calcium channels on angiotensin responses in diabetic rat vasculature. Arun Kumar HS. (2001 to 2004).

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Book Chapters

Peer Reviewed Journals

	Year	Publication
	(2008)	'Progenitor Cell Therapy in a Porcine Acute Myocardial Infarction Model Induces Cardiac Hypertrophy, Mediated by Paracrine Secretion of Cardiotrophic Factors Including TGF beta 1' Doyle, B,Sorajja, P,Hynes, B,Kumar, AHS,Araoz, PA,Stalboerger, PG,Miller, D,Reed, C,Schmeckpeper, J,Wang, S,Liu, CS,Terzic, A,Kruger, D,Riederer, S,Caplice, NM; (2008) 'Progenitor Cell Therapy in a Porcine Acute Myocardial Infarction Model Induces Cardiac Hypertrophy, Mediated by Paracrine Secretion of Cardiotrophic Factors Including TGF beta 1' [DOI] [Details]
	(2010)	'A specific subset of mouse bone marrow cells has smooth muscle cell differentiation capacity' Metharom, Pat; Kumar, Arun HS; Weiss, Sharon; Caplice, Noel M; (2010) 'A specific subset of mouse bone marrow cells has smooth muscle cell differentiation capacity' [Details]
	(2011)	'Pleiotropic role for monocyte C-fms protein in response to vascular injury: Potential therapeutic target' Metharom P, Martin K, Kumar AH, Sawhney N, Cronin MF, McCarthy DG, Maguire AR, Caplice NM; (2011) 'Pleiotropic role for monocyte C-fms protein in response to vascular injury: Potential therapeutic target' [Details]
	(2013)	'Potent endothelial progenitor cell-conditioned media-related anti-apoptotic, cardiotrophic, and pro-angiogenic effects post-myocardial infarction are mediated by insulin-like growth factor-1' Hynes, B,Kumar, AHS,O'Sullivan, J,Buneker, CK,Leblond, AL,Weiss, S,Schmeckpeper, J,Martin, K,Caplice, NM (2013) 'Potent endothelial progenitor cell-conditioned media-related anti-apoptotic, cardiotrophic, and pro-angiogenic effects post-myocardial infarction are mediated by insulin-like growth factor-1' [DOI] [Details]
	(2013)	'Site-specific phosphorylation of the DNA damage response mediator rad9 by cyclin-dependent kinases regulates activation of checkpoint kinase 1' Abreu CM, Kumar R, Hamilton D, Dawdy AW, Creavin K, Eivers S, Finn K, Balsbaugh JL, O'Connor R, Kiely PA, Shabanowitz J, Hunt DF, Grenon M, Lowndes NF (2013) 'Site-specific phosphorylation of the DNA damage response mediator rad9 by cyclin-dependent kinases regulates activation of checkpoint kinase 1' [DOI] [Details]
	(2010)	'A Specific Subset of Mouse Bone Marrow Cells Has Smooth Muscle Cell Differentiation Capacity-Brief Report' Metharom, P; Kumar, AHS; Weiss, S; Caplice, NM; (2010) 'A Specific Subset of Mouse Bone Marrow Cells Has Smooth Muscle Cell Differentiation Capacity-Brief Report' [DOI] [Details]
	(2010)	'Effect of apocynin on NADPH oxidase-mediated oxidative stress-LOX-1-eNOS pathway in human endothelial cells exposed to high glucose' Taye, A,Saad, AH,Kumar, AHS,Morawietz, H; (2010) 'Effect of apocynin on NADPH oxidase-mediated oxidative stress-LOX-1-eNOS pathway in human endothelial cells exposed to high glucose' [DOI] [Details]
	(2011)	'Pleiotropic role for monocyte C-fms protein in response to vascular injury: Potential therapeutic target' Metharom, P,Martin, K,Kumar, AHS,Sawhney, N,Cronin, MF,McCarthy, DG,Maguire, AR,Caplice, NM; (2011) 'Pleiotropic role for monocyte C-fms protein in response to vascular injury: Potential therapeutic target' [DOI] [Details]
	(2011)	'CX3CR1 DEFICIENCY RESULTS IN PROTECTION FROM COLLAGEN-INDUCED ARTHRITIS IN A TRANSGENIC MOUSE MODEL' Murphy, Grainne and Kumar, Arun and Shanahan, Fergus and Harney, Sinead and Molloy, Michael and Caplice, Noel (2011) 'CX3CR1 DEFICIENCY RESULTS IN PROTECTION FROM COLLAGEN-INDUCED ARTHRITIS IN A TRANSGENIC MOUSE MODEL' [Details]
	(2011)	'Potent long-term cardioprotective effects of single low-dose insulin-like growth factor-1 treatment postmyocardial infarction' O'Sullivan JF, Leblond AL, Kelly G, Kumar AH, Metharom P, Büneker CK, Alizadeh-Vikali N, Hristova I, Hynes BG, O'Connor R, Caplice NM (2011) 'Potent long-term cardioprotective effects of single low-dose insulin-like growth factor-1 treatment postmyocardial infarction' [DOI] [Details]
	(2011)	'Potent endothelial progenitor cell-conditioned media-related anti-apoptotic, cardiotrophic, and pro-angiogenic effects post-myocardial infarction are mediated by insulin-like growth factor-1' Hynes B, Kumar AH, O'Sullivan J, Klein Buneker C, Leblond AL, Weiss S, Schmeckpeper J, Martin K, Caplice NM (2011) 'Potent endothelial progenitor cell-conditioned media-related anti-apoptotic, cardiotrophic, and pro-angiogenic effects post-myocardial infarction are mediated by insulin-like growth factor-1' [DOI] [Details]
	(2011)	'Milestones, global presence, and scientific progress' Kumar AH (2011) 'Milestones, global presence, and scientific progress' [DOI] [Details]
	(2011)	'Pleiotropic role for monocyte C-fms protein in response to vascular injury: potential therapeutic target' Metharom P, Martin K, Kumar AH, Sawhney N, Cronin MF, McCarthy DG, Maguire AR, Caplice NM (2011) 'Pleiotropic role for monocyte C-fms protein in response to vascular injury: potential therapeutic target' [DOI] [Details]
	(2012)	'Analysis of attitudes toward the source of progenitor cells in tissue-engineered products for use in burns compared with other disease states' Clover, AJP,O'Neill, BL,Kumar, AHS (2012) 'Analysis of attitudes toward the source of progenitor cells in tissue-engineered products for use in burns compared with other disease states' [DOI] [Details]
	(2011)	'Analysis of public attitudes towards the use of autologous and allogenic cells in tissue engineering products for burns' A.J.P. Clover, B. Lane O’Neill and Arun HS Kumar. (2011) 'Analysis of public attitudes towards the use of autologous and allogenic cells in tissue engineering products for burns' [Details]
	(2011)	'Monocyte recruitment via the CX3CR1 receptor influences burn wound healing' A.J.P. Clover, Arun HS Kumar and Noel M Caplice (2011) 'Monocyte recruitment via the CX3CR1 receptor influences burn wound healing' [Details]
	(2011)	'Deficiency of CX3CR1 delays burn wound healing and is associated with reduced myeloid cell recruitment and decreased sub-dermal angiogenesis' Clover AJ, Kumar AH, Caplice NM; (2011) 'Deficiency of CX3CR1 delays burn wound healing and is associated with reduced myeloid cell recruitment and decreased sub-dermal angiogenesis' [Details]
	(2001)	'Evaluation of the effect of glucose on thiopental anesthesia in mice' Arun Kumar HS*, and Reddy TKK. ; (2001) 'Evaluation of the effect of glucose on thiopental anesthesia in mice' [Details]
	(2011)	'Improved protocol for processing stented porcine coronary arteries for immunostaining' Kumar AH, McCauley SD, Hynes BG, O'Dea J, Caplice NM; (2011) 'Improved protocol for processing stented porcine coronary arteries for immunostaining' [Details]
	(2010)	'Oxidative Stress and Endothelial Dysfunction in Aortae of Aged Spontaneously Hypertensive Rats by NOX1/2 is Reversed by NADPH Oxidase Inhibition' Wind, Sven; Beuerlein, Knut; Armitage, Melanie E; Taye, Ashraf; Kumar, Arun HS; Janowitz, Daniel; Neff, Christina; Shah, Ajay M; Schmidt, Harald HHW; Wingler, Kirstin; (2010) 'Oxidative Stress and Endothelial Dysfunction in Aortae of Aged Spontaneously Hypertensive Rats by NOX1/2 is Reversed by NADPH Oxidase Inhibition' [Details]
	(2010)	'Bone marrow derived CX3CR1 progenitors contribute to neointimal smooth muscle cells via fractalkine CX3CR1 interaction' Kumar, Arun HS; Caplice; Metharom, Pat; Schmeckpeper, Jeffrey; Weiss, Sharon; Martin, Kenneth; Caplice, Noel M; (2010) 'Bone marrow derived CX3CR1 progenitors contribute to neointimal smooth muscle cells via fractalkine CX3CR1 interaction' [Details]
	(2010)	'Clinical potential of adult vascular progenitor cells' Kumar, Arun HS; Caplice; Noel M; (2010) 'Clinical potential of adult vascular progenitor cells' [Details]
	(2009)	'Lentiviral tracking of vascular differentiation in bone marrow progenitor cells' Jeffrey Schmeckpeper, Yasuhiro Ikeda, Arun HS Kumar, Pat Metharom, Stephen J. Russell and Noel M Caplice. ; (2009) 'Lentiviral tracking of vascular differentiation in bone marrow progenitor cells' [Details]
	(2009)	'Myogenic Satellite Cells and Its Application in Animals - A Review' Singh NK, Lee HJ, Jeong DK, Eong DK, Arun HS Kumar, Sharma L, Hwang IH. ; (2009) 'Myogenic Satellite Cells and Its Application in Animals - A Review' [Details]
	(2009)	'Natural products as regulators of progenitor cells: Role in cardiovascular regenerative medicine' Arun HS Kumar, Brian G Hynes, Mueen Ahmed KK. ; (2009) 'Natural products as regulators of progenitor cells: Role in cardiovascular regenerative medicine' [Details]
	(2008)	'White Paper on rat research in the genome and post-genome era: a community view' Authored by the Rat White Paper Writing Consortium (287 Authors). ; (2008) 'White Paper on rat research in the genome and post-genome era: a community view' [Details]
	(2007)	'Preventive and curative effect of edaravone on nerve functions and oxidative stress in experimental diabetic neuropathy' Saini AK, Arun Kumar HS and Sharma SS. ; (2007) 'Preventive and curative effect of edaravone on nerve functions and oxidative stress in experimental diabetic neuropathy' [Details]
	(2007)	'Natural Remedies to Impotence. (Editorial)' Arun HS Kumar; (2007) 'Natural Remedies to Impotence. (Editorial)' [Details]
	(2007)	'Radical radical everywhere, where is the perfect antioxidant?' Arun HS Kumar. ; (2007) 'Radical radical everywhere, where is the perfect antioxidant?' [Details]
	(2006)	'Edaravone attenuates hydroxyl radical stress and augmented angiotensin II response in diabetic rats' Saini AK, Patel RJ, Sharma SS and Arun Kumar HS; (2006) 'Edaravone attenuates hydroxyl radical stress and augmented angiotensin II response in diabetic rats' [Details]
	(2006)	'How are we progressing? (Editorial)' Arun Kumar HS; (2006) 'How are we progressing? (Editorial)' [Details]
	(2006)	'Plant science and its noble contribution (Editorial)' Arun HS Kumar. ; (2006) 'Plant science and its noble contribution (Editorial)' [Details]
	(2006)	'Targeting the heme-oxidized nitric oxide receptor for selective vasodilatation of diseased blood vessels. 2006' Johannes-Peter Stasch, Peter M Schmidt, Pavel I Nedvetsky, Tatiana Y Nedvetskaya, Arun Kumar HS, Sabine Meurer, Martin Deile, Ashraf Taye, Andreas Knorr, Harald Lapp, Helmut Müller, Yagmur Turgay, Christiane Rothkegel, Adrian Tersteegen, Barbara Kemp-Harper, Werner Müller-Esterl and Harald H.H.W. Schmidt. ; (2006) 'Targeting the heme-oxidized nitric oxide receptor for selective vasodilatation of diseased blood vessels. 2006' [Details]
	(2005)	'Beyond NO and heme: biochemical and pharmacological opportunities' Christiane Rothkegel, Peter M Schmidt, Arun Kumar HS, Friederike Stoll, Harald Lapp, Frank Wunder, Henning Schröder, Matthias Rinke, Harald HHW Schmidt and Johannes-Peter Stasch. ; (2005) 'Beyond NO and heme: biochemical and pharmacological opportunities' [Details]
	(2005)	'(a polyherbal formulation of W. somnifera, O. sanctum, and E. officinalis) prevents salinomycin toxicity in broiler chicks' Arun Kumar HS*, Manjunath HS and Reddy KS and Reddy R. Zeetress ; (2005) '(a polyherbal formulation of W. somnifera, O. sanctum, and E. officinalis) prevents salinomycin toxicity in broiler chicks' [Details]
	(2005)	'Structural analysis of isoform-specific inhibitors targeting the tetrahydrobiopterin binding site of human nitric oxide synthases' Hans Matter, Arun Kumar HS*, Roman Fedorov, Armin Frey, Peter Kotsonis, Elisabeth Hartmann, Lothar G. Fröhlich, Andreas Reif, Wolfgang Pfleiderer, Peter Scheurer, Dipak K. Ghosh, Ilme Schlichting and Harald HHW Schmidt. ; (2005) 'Structural analysis of isoform-specific inhibitors targeting the tetrahydrobiopterin binding site of human nitric oxide synthases' [Details]
	(2005)	'AT1 receptors and L-type calcium channels: functional coupling in supersensitivity to angiotensin II in diabetic rats' Arun KHS*, Kaul CL and Ramarao P. ; (2005) 'AT1 receptors and L-type calcium channels: functional coupling in supersensitivity to angiotensin II in diabetic rats' [Details]
	(2005)	'Effects of adenosine and adenosine A2A receptor agonist on motor nerve conduction velocity and nerve blood flow in experimental diabetic neuropathy' Sokindra K, Arun KHS, Kaul CL and Sharma SS.; (2005) 'Effects of adenosine and adenosine A2A receptor agonist on motor nerve conduction velocity and nerve blood flow in experimental diabetic neuropathy' [Details]
	(2005)	'Mother Nature¿s gift to combat oxidative stress' Neurological Research; (2005) 'Mother Nature¿s gift to combat oxidative stress' [Details]
	(2005)	'Where do we stand !!!. (Editorial)' Arun Kumar HS. ; (2005) 'Where do we stand !!!. (Editorial)' [Details]
	(2005)	'A meeting inspiring the young minds: Yet another noble venture from the Nobel laureates' Arun Kumar HS. ; (2005) 'A meeting inspiring the young minds: Yet another noble venture from the Nobel laureates' [Details]
	(2005)	'Preclinical safety studies on medicinal plants: Part II' Arun Kumar HS; (2005) 'Preclinical safety studies on medicinal plants: Part II' [Details]
	(2005)	'Preclinical safety studies on medicinal plants: Part 1' Arun Kumar HS; (2005) 'Preclinical safety studies on medicinal plants: Part 1' [Details]
	(2005)	'Saga of renin angiotensin system and calcium channels in hypertensive diabetics: Does it have a therapeutic edge?' Arun Kumar HS* and Ramarao P. ; (2005) 'Saga of renin angiotensin system and calcium channels in hypertensive diabetics: Does it have a therapeutic edge?' [Details]
	(2005)	'Green fluorescent proteins in receptorology: An emerging tool in drug discovery' Arun KHS, Kaul CL and Ramarao P. ; (2005) 'Green fluorescent proteins in receptorology: An emerging tool in drug discovery' [Details]
	(2004)	'Reduced cGMP signaling associated with neointimal proliferation and vascular dysfunction in late stage atherosclerosis' Volker O. Melichar, Delphine Behr-Roussel, Ulrike Zabel, L. Otto Uttenthal, José Rodrigo, Alain Rupin, Tony J. Verbeuren, Arun Kumar HS*, and Harald H.H.W. Schmidt. ; (2004) 'Reduced cGMP signaling associated with neointimal proliferation and vascular dysfunction in late stage atherosclerosis' [Details]
	(2004)	'Tempol augments angiotensin II induced AT2-receptor mediated relaxation in diabetic rat thoracic aorta' Arun KHS, Kaul CL and Ramarao P. ; (2004) 'Tempol augments angiotensin II induced AT2-receptor mediated relaxation in diabetic rat thoracic aorta' [Details]
	(2004)	'In vitro high glucose concentration augments angiotensin II mediated contraction via AT1 receptors in control but not diabetic rat thoracic aorta' Arun KHS, Kaul CL and Ramarao P. ; (2004) 'In vitro high glucose concentration augments angiotensin II mediated contraction via AT1 receptors in control but not diabetic rat thoracic aorta' [Details]
	(2004)	'Acute hyperglycemia attenuates nerve conduction velocity and nerve blood flow in male Sprague-Dawley rats: Reversal by adenosine' Saini AK, Arun KHS, Kaul CL, Sharma SS. ; (2004) 'Acute hyperglycemia attenuates nerve conduction velocity and nerve blood flow in male Sprague-Dawley rats: Reversal by adenosine' [Details]
	(2004)	'Effect of ¿Zeetress¿ on aflatoxin depressed growth and immunity in broilers' Ratan Kumar M, Kala Kumar B, Arun Kumar HS, and Reddy KS. ; (2004) 'Effect of ¿Zeetress¿ on aflatoxin depressed growth and immunity in broilers' [Details]
	(2004)	'Synthesis and Evaluation of S-4-(3-thienyl)phenyl-methylacetic acid' Shilpi M, Alpeshkumar M, Selvam C, Arun KHS, Johar PS, Sanjay MJ, Ramarao P, Bharatam PV and Chawla HPS. ; (2004) 'Synthesis and Evaluation of S-4-(3-thienyl)phenyl-methylacetic acid' [Details]
	(2003)	'Ca2+ trapped in smooth muscle cell signal web' Patel RJ, Prajapati KD, Arun KHS and Thyagarajan B; (2003) 'Ca2+ trapped in smooth muscle cell signal web' [Details]
	(2003)	'Effect of sub-acute doses of Maduramycin in Broiler Chicks' Arun KHS*, Manjunath HS, Reddy KS, Reddy R, Kala kumar B; (2003) 'Effect of sub-acute doses of Maduramycin in Broiler Chicks' [Details]
	(2003)	'Sub-acute oral toxicity of Salinomycin in broiler chicks' Arun KHS*, Manjunath HS, Reddy KS, Reddy R. ; (2003) 'Sub-acute oral toxicity of Salinomycin in broiler chicks' [Details]
	(2002)	'Acute toxicity studies on custard seed oil in mice' Arun Kumar HS*, Kala Kumar B. and Reddy KS. ; (2002) 'Acute toxicity studies on custard seed oil in mice' [Details]
	(2002)	'Effect of ¿Zeetress¿ on aflatoxin induced humoral immunosuppression in broiler chicks' Ratan Kumar M, Arun Kumar HS*, Kala Kumar B. and Reddy KS. ; (2002) 'Effect of ¿Zeetress¿ on aflatoxin induced humoral immunosuppression in broiler chicks' [Details]
	(2001)	'Effect of custard seed oil on immune response of chicks vaccinated with NDV and S.gallinarum vaccine' Arun Kumar HS*, Kala Kumar B. and Reddy KS. ; (2001) 'Effect of custard seed oil on immune response of chicks vaccinated with NDV and S.gallinarum vaccine' [Details]
	(2000)	'Effect of ¿Zeetress¿ on immune response in custard seed oil induced immunosuppression in broiler chicks' Arun Kumar HS*, Kala Kumar B. and Reddy KS. ; (2000) 'Effect of ¿Zeetress¿ on immune response in custard seed oil induced immunosuppression in broiler chicks' [Details]
	(2000)	'Evaluation of custard seed oil and neem oil as acaricides' Kala Kumar B, Arun Kumar HS*, Ashok Kumar B and Reddy KS. ; (2000) 'Evaluation of custard seed oil and neem oil as acaricides' [Details]

Conference Publications

Abstract

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Teaching Interests

Mentoring and Teaching Skills

Seven years of experience in teaching and training UG, PG and PhD candidates (Veterinary, Pharmacy and Medicine) in the field of general physiology, pharmacology, Cardiovascular medicine/pharmacology and stem cells biology.

Student’s trained/supervised: PhD Students: 4, Masters students: 9, Medical (MD) students: 4, Technical/research assistants: 6