Research Profile

Arun Kumar

BIOGRAPHY

A Pharmacologist and veterinarian with ten years of research and clinical experience in preclinical pharmacology, vascular and cardiovascular research, microsurgery, preclinical imaging, regenerative medicine, rodent colony management and cell biology. Adaptable, creative and enthusiastic scientist with leadership skills to direct and develop productive team in basic and applied research.



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Research Interests

Preclinical pharmacology, vascular and cardiovascular disease research, microsurgery, preclinical imaging, regenerative medicine and cell biology. 

Research Techniques



Vascular, cardiovascular and neurovascular functional phenotyping as part of preclinical and safety pharmacology.



Imaging: Intravital, fluoroscopy, multiphoton, confocal microscopy, CT-PET, SEM.



Preclinical drug discovery: GLP based In vivo and in vitro pharmacodynamic and pharmacokinetic studies.



Developing rodent and porcine models of vascular and myocardial remodelling.



Creating animal models of diabetes, hypertension and inflammation.



Expertise in 2D and 3D Image analysis (IMARIS software).



Single cell functional phenotyping (Endothelial and smooth muscle progenitor cells, cardiomyocytes, monocytes, macrophages, smooth muscle and endothelial cell primary cultures and established cell lines).



Pathological, histopathological, immunohistochemistry and biochemical techniques.



Rodent and porcine colony management.



Statistical evaluation of biological data.



 



Project management skills



Have independently/as team member managed the following research projects:



Role of Progenitor cells in cardiovascular pathophysiology.



Cardio protective effects of low dose IGF1 .



CX3CR1 cytokine network in restenosis and plaque angiogenesis.



Developing next generations of cytokine eluting stents.



Developing progenitor cells/secreted factors for treating burn wounds.



Studies on the role of NADPH Oxidases and soluble Guanylyl Cyclases in cardiovascular/vascular/neurological pathophysiology. (Postdoc).



Studies on the role of calcium channels on angiotensin responses in diabetic rat vasculature (Ph.D. Thesis).



Studies on the role of antioxidants in combating salinomycin and maduramycin toxicity in broiler chicks (M.V.Sc Thesis).



Role of oxidative stress in enhanced vascular and nonvascular contractions in diabetic rats.



Acute hyperglycemic effects induced changes in motor nerve conduction velocity and nerve blood flow: Identifying the mechanisms involved.



Role of oxidative stress and adenosinergic receptors in diabetic neuropathy.



Advanced glycation end product breakers in combating type I & II diabetic vascular complications. (Industrial Project).



Dipeptidyl peptidase IV inhibitors in therapy of type II diabetes. (Industrial Project).



Screening of novel diclofenac formulations for their analgesic and anti-inflammatory activity in rodent model. (Industrial Project).
 

Grants/Fellowships

Science Foundation Ireland-TIDA Entrepreneurship award. Arun HS Kumar. (2011-2012)

British Burns Association Research Grant. James Clover and Arun HS Kumar. Application of circulating progenitor cells on the burn wound to enhance the rate of burn wound healing. (2010-2011).

Enterprise Ireland. Development of IGF1 stent. Noel M Caplice and Arun HS Kumar. (2010-2011).

Irish Heart Foundation. Cardiac Angiogenesis: ‘Cell based bypass’ of chronic vascular occlusions. Brian G Hynes and Arun Kumar HS. (2007-2009).

NHMRC Grant (384163), Australia. Defining the role of NADPH oxidases in vascular remodelling and arterial hypertension. Grant Drummond, Arun Kumar HS, Harald HHW Schmidt, Chris Sobby and Robert Widdop. (2006 to 2008).

Senior Research Fellowship, CSIR, India. Studies on the role of calcium channels on angiotensin responses in diabetic rat vasculature. Arun Kumar HS. (2001 to 2004).

Publications

Book Chapters

 YearPublication
(2011)'Compromised cytology of bovine udder during mastitis: Therapeutic potential of adult stem/progenitor cells'
Arun HS Kumar and Naresh Kumar Singh; (2011) 'Compromised cytology of bovine udder during mastitis: Therapeutic potential of adult stem/progenitor cells' In: Neelesh Sharma, Naresh Kumar Singh and Goran Bacic (eds). Production diseases of dairy animals. Delhi, India: Satish Serial Publishing House, Delhi, India. [Details]
(2008)'Comprehensive Review of Literature'
Arun HS Kumar. ; (2008) 'Comprehensive Review of Literature' In: Gupta YK, Jagadeesh G, Murthy S and Prakash (eds). A edited `From getting started in research to presenting data in a scientific paper¿. Auckland, New Zealand: Wolters Kulwer Health. [Details]
(2008)'Phytopharmacological Screening of Natural Products'
Mueen Ahmed KK and Arun Kumar HS. ; (2008) 'Phytopharmacological Screening of Natural Products' In: Hiremath SRR (eds). Text book of Industrial Pharmacy (Drug delivery systems and cosmetic and herbal drug technology). Chennai, India: Orient Longman Pvt Ltd. [Details]
(2008)'Patents and Intellectual Property on Natural Products - An Overview'
Mueen Ahmed KK and Arun Kumar HS. ; (2008) 'Patents and Intellectual Property on Natural Products - An Overview' In: Hiremath SRR (eds). Text book of Industrial Pharmacy (Drug delivery systems and cosmetic and herbal drug technology)¿. Chennai, India: Orient Longman Pvt Ltd. [Details]

Peer Reviewed Journals

 YearPublication
(2008)'Progenitor Cell Therapy in a Porcine Acute Myocardial Infarction Model Induces Cardiac Hypertrophy, Mediated by Paracrine Secretion of Cardiotrophic Factors Including TGF beta 1'
Doyle, B,Sorajja, P,Hynes, B,Kumar, AHS,Araoz, PA,Stalboerger, PG,Miller, D,Reed, C,Schmeckpeper, J,Wang, S,Liu, CS,Terzic, A,Kruger, D,Riederer, S,Caplice, NM; (2008) 'Progenitor Cell Therapy in a Porcine Acute Myocardial Infarction Model Induces Cardiac Hypertrophy, Mediated by Paracrine Secretion of Cardiotrophic Factors Including TGF beta 1' [DOI] [Details]
(2010)'A specific subset of mouse bone marrow cells has smooth muscle cell differentiation capacity'
Metharom, Pat; Kumar, Arun HS; Weiss, Sharon; Caplice, Noel M; (2010) 'A specific subset of mouse bone marrow cells has smooth muscle cell differentiation capacity' [Details]
(2011)'Pleiotropic role for monocyte C-fms protein in response to vascular injury: Potential therapeutic target'
Metharom P, Martin K, Kumar AH, Sawhney N, Cronin MF, McCarthy DG, Maguire AR, Caplice NM; (2011) 'Pleiotropic role for monocyte C-fms protein in response to vascular injury: Potential therapeutic target'   [Details]
(2013)'Potent endothelial progenitor cell-conditioned media-related anti-apoptotic, cardiotrophic, and pro-angiogenic effects post-myocardial infarction are mediated by insulin-like growth factor-1'
Hynes, B,Kumar, AHS,O'Sullivan, J,Buneker, CK,Leblond, AL,Weiss, S,Schmeckpeper, J,Martin, K,Caplice, NM (2013) 'Potent endothelial progenitor cell-conditioned media-related anti-apoptotic, cardiotrophic, and pro-angiogenic effects post-myocardial infarction are mediated by insulin-like growth factor-1' [DOI] [Details]
(2013)'Site-specific phosphorylation of the DNA damage response mediator rad9 by cyclin-dependent kinases regulates activation of checkpoint kinase 1'
Abreu CM, Kumar R, Hamilton D, Dawdy AW, Creavin K, Eivers S, Finn K, Balsbaugh JL, O'Connor R, Kiely PA, Shabanowitz J, Hunt DF, Grenon M, Lowndes NF (2013) 'Site-specific phosphorylation of the DNA damage response mediator rad9 by cyclin-dependent kinases regulates activation of checkpoint kinase 1' [DOI] [Details]
(2010)'A Specific Subset of Mouse Bone Marrow Cells Has Smooth Muscle Cell Differentiation Capacity-Brief Report'
Metharom, P; Kumar, AHS; Weiss, S; Caplice, NM; (2010) 'A Specific Subset of Mouse Bone Marrow Cells Has Smooth Muscle Cell Differentiation Capacity-Brief Report' [DOI] [Details]
(2010)'Effect of apocynin on NADPH oxidase-mediated oxidative stress-LOX-1-eNOS pathway in human endothelial cells exposed to high glucose'
Taye, A,Saad, AH,Kumar, AHS,Morawietz, H; (2010) 'Effect of apocynin on NADPH oxidase-mediated oxidative stress-LOX-1-eNOS pathway in human endothelial cells exposed to high glucose' [DOI] [Details]
(2011)'Pleiotropic role for monocyte C-fms protein in response to vascular injury: Potential therapeutic target'
Metharom, P,Martin, K,Kumar, AHS,Sawhney, N,Cronin, MF,McCarthy, DG,Maguire, AR,Caplice, NM; (2011) 'Pleiotropic role for monocyte C-fms protein in response to vascular injury: Potential therapeutic target' [DOI] [Details]
(2011)'CX3CR1 DEFICIENCY RESULTS IN PROTECTION FROM COLLAGEN-INDUCED ARTHRITIS IN A TRANSGENIC MOUSE MODEL'
Murphy, Grainne and Kumar, Arun and Shanahan, Fergus and Harney, Sinead and Molloy, Michael and Caplice, Noel (2011) 'CX3CR1 DEFICIENCY RESULTS IN PROTECTION FROM COLLAGEN-INDUCED ARTHRITIS IN A TRANSGENIC MOUSE MODEL' [Details]
(2011)'Potent long-term cardioprotective effects of single low-dose insulin-like growth factor-1 treatment postmyocardial infarction'
O'Sullivan JF, Leblond AL, Kelly G, Kumar AH, Metharom P, Büneker CK, Alizadeh-Vikali N, Hristova I, Hynes BG, O'Connor R, Caplice NM (2011) 'Potent long-term cardioprotective effects of single low-dose insulin-like growth factor-1 treatment postmyocardial infarction' [DOI] [Details]
(2011)'Potent endothelial progenitor cell-conditioned media-related anti-apoptotic, cardiotrophic, and pro-angiogenic effects post-myocardial infarction are mediated by insulin-like growth factor-1'
Hynes B, Kumar AH, O'Sullivan J, Klein Buneker C, Leblond AL, Weiss S, Schmeckpeper J, Martin K, Caplice NM (2011) 'Potent endothelial progenitor cell-conditioned media-related anti-apoptotic, cardiotrophic, and pro-angiogenic effects post-myocardial infarction are mediated by insulin-like growth factor-1' [DOI] [Details]
(2011)'Milestones, global presence, and scientific progress'
Kumar AH (2011) 'Milestones, global presence, and scientific progress' [DOI] [Details]
(2011)'Pleiotropic role for monocyte C-fms protein in response to vascular injury: potential therapeutic target'
Metharom P, Martin K, Kumar AH, Sawhney N, Cronin MF, McCarthy DG, Maguire AR, Caplice NM (2011) 'Pleiotropic role for monocyte C-fms protein in response to vascular injury: potential therapeutic target' [DOI] [Details]
(2012)'Analysis of attitudes toward the source of progenitor cells in tissue-engineered products for use in burns compared with other disease states'
Clover, AJP,O'Neill, BL,Kumar, AHS (2012) 'Analysis of attitudes toward the source of progenitor cells in tissue-engineered products for use in burns compared with other disease states' [DOI] [Details]
(2011)'Analysis of public attitudes towards the use of autologous and allogenic cells in tissue engineering products for burns'
A.J.P. Clover, B. Lane O’Neill and Arun HS Kumar. (2011) 'Analysis of public attitudes towards the use of autologous and allogenic cells in tissue engineering products for burns' [Details]
(2011)'Monocyte recruitment via the CX3CR1 receptor influences burn wound healing'
A.J.P. Clover, Arun HS Kumar and Noel M Caplice (2011) 'Monocyte recruitment via the CX3CR1 receptor influences burn wound healing' [Details]
(2011)'Deficiency of CX3CR1 delays burn wound healing and is associated with reduced myeloid cell recruitment and decreased sub-dermal angiogenesis'
Clover AJ, Kumar AH, Caplice NM; (2011) 'Deficiency of CX3CR1 delays burn wound healing and is associated with reduced myeloid cell recruitment and decreased sub-dermal angiogenesis'   [Details]
(2001)'Evaluation of the effect of glucose on thiopental anesthesia in mice'
Arun Kumar HS*, and Reddy TKK. ; (2001) 'Evaluation of the effect of glucose on thiopental anesthesia in mice' [Details]
(2011)'Improved protocol for processing stented porcine coronary arteries for immunostaining'
Kumar AH, McCauley SD, Hynes BG, O'Dea J, Caplice NM; (2011) 'Improved protocol for processing stented porcine coronary arteries for immunostaining'   [Details]
(2010)'Oxidative Stress and Endothelial Dysfunction in Aortae of Aged Spontaneously Hypertensive Rats by NOX1/2 is Reversed by NADPH Oxidase Inhibition'
Wind, Sven; Beuerlein, Knut; Armitage, Melanie E; Taye, Ashraf; Kumar, Arun HS; Janowitz, Daniel; Neff, Christina; Shah, Ajay M; Schmidt, Harald HHW; Wingler, Kirstin; (2010) 'Oxidative Stress and Endothelial Dysfunction in Aortae of Aged Spontaneously Hypertensive Rats by NOX1/2 is Reversed by NADPH Oxidase Inhibition' [Details]
(2010)'Bone marrow derived CX3CR1 progenitors contribute to neointimal smooth muscle cells via fractalkine CX3CR1 interaction'
Kumar, Arun HS; Caplice; Metharom, Pat; Schmeckpeper, Jeffrey; Weiss, Sharon; Martin, Kenneth; Caplice, Noel M; (2010) 'Bone marrow derived CX3CR1 progenitors contribute to neointimal smooth muscle cells via fractalkine CX3CR1 interaction' [Details]
(2010)'Clinical potential of adult vascular progenitor cells'
Kumar, Arun HS; Caplice; Noel M; (2010) 'Clinical potential of adult vascular progenitor cells' [Details]
(2009)'Lentiviral tracking of vascular differentiation in bone marrow progenitor cells'
Jeffrey Schmeckpeper, Yasuhiro Ikeda, Arun HS Kumar, Pat Metharom, Stephen J. Russell and Noel M Caplice. ; (2009) 'Lentiviral tracking of vascular differentiation in bone marrow progenitor cells' [Details]
(2009)'Myogenic Satellite Cells and Its Application in Animals - A Review'
Singh NK, Lee HJ, Jeong DK, Eong DK, Arun HS Kumar, Sharma L, Hwang IH. ; (2009) 'Myogenic Satellite Cells and Its Application in Animals - A Review' [Details]
(2009)'Natural products as regulators of progenitor cells: Role in cardiovascular regenerative medicine'
Arun HS Kumar, Brian G Hynes, Mueen Ahmed KK. ; (2009) 'Natural products as regulators of progenitor cells: Role in cardiovascular regenerative medicine' [Details]
(2008)'White Paper on rat research in the genome and post-genome era: a community view'
Authored by the Rat White Paper Writing Consortium (287 Authors). ; (2008) 'White Paper on rat research in the genome and post-genome era: a community view' [Details]
(2007)'Preventive and curative effect of edaravone on nerve functions and oxidative stress in experimental diabetic neuropathy'
Saini AK, Arun Kumar HS and Sharma SS. ; (2007) 'Preventive and curative effect of edaravone on nerve functions and oxidative stress in experimental diabetic neuropathy' [Details]
(2007)'Natural Remedies to Impotence. (Editorial)'
Arun HS Kumar; (2007) 'Natural Remedies to Impotence. (Editorial)' [Details]
(2007)'Radical radical everywhere, where is the perfect antioxidant?'
Arun HS Kumar. ; (2007) 'Radical radical everywhere, where is the perfect antioxidant?' [Details]
(2006)'Edaravone attenuates hydroxyl radical stress and augmented angiotensin II response in diabetic rats'
Saini AK, Patel RJ, Sharma SS and Arun Kumar HS; (2006) 'Edaravone attenuates hydroxyl radical stress and augmented angiotensin II response in diabetic rats' [Details]
(2006)'How are we progressing? (Editorial)'
Arun Kumar HS; (2006) 'How are we progressing? (Editorial)' [Details]
(2006)'Plant science and its noble contribution (Editorial)'
Arun HS Kumar. ; (2006) 'Plant science and its noble contribution (Editorial)' [Details]
(2006)'Targeting the heme-oxidized nitric oxide receptor for selective vasodilatation of diseased blood vessels. 2006'
Johannes-Peter Stasch, Peter M Schmidt, Pavel I Nedvetsky, Tatiana Y Nedvetskaya, Arun Kumar HS, Sabine Meurer, Martin Deile, Ashraf Taye, Andreas Knorr, Harald Lapp, Helmut Müller, Yagmur Turgay, Christiane Rothkegel, Adrian Tersteegen, Barbara Kemp-Harper, Werner Müller-Esterl and Harald H.H.W. Schmidt. ; (2006) 'Targeting the heme-oxidized nitric oxide receptor for selective vasodilatation of diseased blood vessels. 2006' [Details]
(2005)'Beyond NO and heme: biochemical and pharmacological opportunities'
Christiane Rothkegel, Peter M Schmidt, Arun Kumar HS, Friederike Stoll, Harald Lapp, Frank Wunder, Henning Schröder, Matthias Rinke, Harald HHW Schmidt and Johannes-Peter Stasch. ; (2005) 'Beyond NO and heme: biochemical and pharmacological opportunities' [Details]
(2005)'(a polyherbal formulation of W. somnifera, O. sanctum, and E. officinalis) prevents salinomycin toxicity in broiler chicks'
Arun Kumar HS*, Manjunath HS and Reddy KS and Reddy R. Zeetress ; (2005) '(a polyherbal formulation of W. somnifera, O. sanctum, and E. officinalis) prevents salinomycin toxicity in broiler chicks' [Details]
(2005)'Structural analysis of isoform-specific inhibitors targeting the tetrahydrobiopterin binding site of human nitric oxide synthases'
Hans Matter, Arun Kumar HS*, Roman Fedorov, Armin Frey, Peter Kotsonis, Elisabeth Hartmann, Lothar G. Fröhlich, Andreas Reif, Wolfgang Pfleiderer, Peter Scheurer, Dipak K. Ghosh, Ilme Schlichting and Harald HHW Schmidt. ; (2005) 'Structural analysis of isoform-specific inhibitors targeting the tetrahydrobiopterin binding site of human nitric oxide synthases' [Details]
(2005)'AT1 receptors and L-type calcium channels: functional coupling in supersensitivity to angiotensin II in diabetic rats'
Arun KHS*, Kaul CL and Ramarao P. ; (2005) 'AT1 receptors and L-type calcium channels: functional coupling in supersensitivity to angiotensin II in diabetic rats' [Details]
(2005)'Effects of adenosine and adenosine A2A receptor agonist on motor nerve conduction velocity and nerve blood flow in experimental diabetic neuropathy'
Sokindra K, Arun KHS, Kaul CL and Sharma SS.; (2005) 'Effects of adenosine and adenosine A2A receptor agonist on motor nerve conduction velocity and nerve blood flow in experimental diabetic neuropathy' [Details]
(2005)'Mother Nature¿s gift to combat oxidative stress'
Neurological Research; (2005) 'Mother Nature¿s gift to combat oxidative stress' [Details]
(2005)'Where do we stand !!!. (Editorial)'
Arun Kumar HS. ; (2005) 'Where do we stand !!!. (Editorial)' [Details]
(2005)'A meeting inspiring the young minds: Yet another noble venture from the Nobel laureates'
Arun Kumar HS. ; (2005) 'A meeting inspiring the young minds: Yet another noble venture from the Nobel laureates' [Details]
(2005)'Preclinical safety studies on medicinal plants: Part II'
Arun Kumar HS; (2005) 'Preclinical safety studies on medicinal plants: Part II' [Details]
(2005)'Preclinical safety studies on medicinal plants: Part 1'
Arun Kumar HS; (2005) 'Preclinical safety studies on medicinal plants: Part 1' [Details]
(2005)'Saga of renin angiotensin system and calcium channels in hypertensive diabetics: Does it have a therapeutic edge?'
Arun Kumar HS* and Ramarao P. ; (2005) 'Saga of renin angiotensin system and calcium channels in hypertensive diabetics: Does it have a therapeutic edge?' [Details]
(2005)'Green fluorescent proteins in receptorology: An emerging tool in drug discovery'
Arun KHS, Kaul CL and Ramarao P. ; (2005) 'Green fluorescent proteins in receptorology: An emerging tool in drug discovery' [Details]
(2004)'Reduced cGMP signaling associated with neointimal proliferation and vascular dysfunction in late stage atherosclerosis'
Volker O. Melichar, Delphine Behr-Roussel, Ulrike Zabel, L. Otto Uttenthal, José Rodrigo, Alain Rupin, Tony J. Verbeuren, Arun Kumar HS*, and Harald H.H.W. Schmidt. ; (2004) 'Reduced cGMP signaling associated with neointimal proliferation and vascular dysfunction in late stage atherosclerosis' [Details]
(2004)'Tempol augments angiotensin II induced AT2-receptor mediated relaxation in diabetic rat thoracic aorta'
Arun KHS, Kaul CL and Ramarao P. ; (2004) 'Tempol augments angiotensin II induced AT2-receptor mediated relaxation in diabetic rat thoracic aorta' [Details]
(2004)'In vitro high glucose concentration augments angiotensin II mediated contraction via AT1 receptors in control but not diabetic rat thoracic aorta'
Arun KHS, Kaul CL and Ramarao P. ; (2004) 'In vitro high glucose concentration augments angiotensin II mediated contraction via AT1 receptors in control but not diabetic rat thoracic aorta' [Details]
(2004)'Acute hyperglycemia attenuates nerve conduction velocity and nerve blood flow in male Sprague-Dawley rats: Reversal by adenosine'
Saini AK, Arun KHS, Kaul CL, Sharma SS. ; (2004) 'Acute hyperglycemia attenuates nerve conduction velocity and nerve blood flow in male Sprague-Dawley rats: Reversal by adenosine' [Details]
(2004)'Effect of ¿Zeetress¿ on aflatoxin depressed growth and immunity in broilers'
Ratan Kumar M, Kala Kumar B, Arun Kumar HS, and Reddy KS. ; (2004) 'Effect of ¿Zeetress¿ on aflatoxin depressed growth and immunity in broilers' [Details]
(2004)'Synthesis and Evaluation of S-4-(3-thienyl)phenyl-methylacetic acid'
Shilpi M, Alpeshkumar M, Selvam C, Arun KHS, Johar PS, Sanjay MJ, Ramarao P, Bharatam PV and Chawla HPS. ; (2004) 'Synthesis and Evaluation of S-4-(3-thienyl)phenyl-methylacetic acid' [Details]
(2003)'Ca2+ trapped in smooth muscle cell signal web'
Patel RJ, Prajapati KD, Arun KHS and Thyagarajan B; (2003) 'Ca2+ trapped in smooth muscle cell signal web' [Details]
(2003)'Effect of sub-acute doses of Maduramycin in Broiler Chicks'
Arun KHS*, Manjunath HS, Reddy KS, Reddy R, Kala kumar B; (2003) 'Effect of sub-acute doses of Maduramycin in Broiler Chicks' [Details]
(2003)'Sub-acute oral toxicity of Salinomycin in broiler chicks'
Arun KHS*, Manjunath HS, Reddy KS, Reddy R. ; (2003) 'Sub-acute oral toxicity of Salinomycin in broiler chicks' [Details]
(2002)'Acute toxicity studies on custard seed oil in mice'
Arun Kumar HS*, Kala Kumar B. and Reddy KS. ; (2002) 'Acute toxicity studies on custard seed oil in mice' [Details]
(2002)'Effect of ¿Zeetress¿ on aflatoxin induced humoral immunosuppression in broiler chicks'
Ratan Kumar M, Arun Kumar HS*, Kala Kumar B. and Reddy KS. ; (2002) 'Effect of ¿Zeetress¿ on aflatoxin induced humoral immunosuppression in broiler chicks' [Details]
(2001)'Effect of custard seed oil on immune response of chicks vaccinated with NDV and S.gallinarum vaccine'
Arun Kumar HS*, Kala Kumar B. and Reddy KS. ; (2001) 'Effect of custard seed oil on immune response of chicks vaccinated with NDV and S.gallinarum vaccine' [Details]
(2000)'Effect of ¿Zeetress¿ on immune response in custard seed oil induced immunosuppression in broiler chicks'
Arun Kumar HS*, Kala Kumar B. and Reddy KS. ; (2000) 'Effect of ¿Zeetress¿ on immune response in custard seed oil induced immunosuppression in broiler chicks' [Details]
(2000)'Evaluation of custard seed oil and neem oil as acaricides'
Kala Kumar B, Arun Kumar HS*, Ashok Kumar B and Reddy KS. ; (2000) 'Evaluation of custard seed oil and neem oil as acaricides' [Details]

Conference Publications

 YearPublication
(2003)Indian Pharmacological Society Conference (IPS-2003). New Delhi, India, p 150
Arun Kumar HS, Kaul CL and Ramarao P. (2003) Functional coupling of AT1 receptors and dihydropyridine sensitive divalent cation channels in angiotensin II induced contraction in rat thoracic aorta Indian Pharmacological Society Conference (IPS-2003). New Delhi, India, p 150 [Details]
(2003)23rd annual conference of Society of Toxicology, 2003. Chennai, India
Arun Kumar HS, Manjunath HS, Reddy KS, Ramasubba Reddy & Kalakumar B. (2003) Sub acute oral toxicity of maduramycin in broiler chicks: role of antioxidant enzymes and biochemical profiles 23rd annual conference of Society of Toxicology, 2003. Chennai, India [Details]
(2003)Indian Pharmacological Society Conference (IPS-2003). New Delhi, India, p 152
Saini AK, Arun Kumar HS, Kaul CL and Sharma SS. (2003) Acute hyperglycemia attenuates nerve conduction velocity and nerve blood flow in healthy male Sprague-Dawley rats Indian Pharmacological Society Conference (IPS-2003). New Delhi, India, p 152 [Details]
(2004)9th NO forum der deutschsprachigen laender-2004. Mainz, Germany. p 22
Arun KHS, Martin Deile and Harald H.H.W. Schmidt. (2004) Selective augmented vasorelaxing efficacy of BAY 58-2667 versus nitric oxide under oxidative stress 9th NO forum der deutschsprachigen laender-2004. Mainz, Germany. p 22 [Details]
(2004)1st Asian Symposium for pharmaceutical Sciences 2004, Fukuoka, Japan, p 92-93
Arun KHS, Srikumar BN, Ramarao P and Kaul CL. (2004) Role of superoxides in supersensitivity to angiotensin II in diabetic rat thoracic aorta 1st Asian Symposium for pharmaceutical Sciences 2004, Fukuoka, Japan, p 92-93 [Details]
(2004)International symposium on Recent Advances in Pharmacology- 2004. New Delhi, India, p 128-129
Arun Kumar HS, Kaul CL and Ramarao P. (2004) Functional coupling of AT1 receptor and dihydropyridine sensitive L-type calcium channel via phospholipase D-diacylglycerol pathway in rat thoracic International symposium on Recent Advances in Pharmacology- 2004. New Delhi, India, p 128-129 [Details]
(2004)1st Asian Symposium for pharmaceutical Sciences 2004, Fukuoka, Japan, p 78-79
Arun KHS, Kaul CL and Ramarao P. (2004) Augmented angiotensin II induced relaxation via AT2-receptor in diabetic vasculature 1st Asian Symposium for pharmaceutical Sciences 2004, Fukuoka, Japan, p 78-79 [Details]
(2005)Ist International Conference on Frontiers in Vascular Medicine 2005, Melbourne, Australia, p 46
Stasch JP, Rothkegel C, Arun Kumar HS, Wunder F, Schroeder H, Schmidt HHHW, Schmidt PM. (2005) NO- and heme-independent activation of soluble guanylate cyclase: Biochemical and Pharmacological opportunities Ist International Conference on Frontiers in Vascular Medicine 2005, Melbourne, Australia, p 46 [Details]
(2005)Ist International Conference on Frontiers in Vascular Medicine 2005, Melbourne, Australia, p 46
Arun Kumar HS. (2005) Vasoconstrictors and calcium channels: Does the romance couple in a sweet way? Ist International Conference on Frontiers in Vascular Medicine 2005, Melbourne, Australia, p 46 [Details]
(2007)Research Interaction Workshop. Royal College of Surgeons, Dublin, Ireland. 2007
Arun HS Kumar. (2007) Large animal imaging and Translational animal facility Research Interaction Workshop. Royal College of Surgeons, Dublin, Ireland. 2007 [Details]
(2008)European Society of Cardiology. 30th Aug-3rd Sept 2008; Munich, Germany. P4690. European Heart Journal (2008) 29 (Abstract Supplement), 810
A Mohamed, B Hynes, A Kumar, G Murphy, A Elsiddig, K Bennett, V Young, M Tolan, E mcgovern, D Keane. (2008) Acute epicardial multi-site biventricular pacing after coronary artery bypass surgery European Society of Cardiology. 30th Aug-3rd Sept 2008; Munich, Germany. P4690. European Heart Journal (2008) 29 (Abstract Supplement), 810 [Details]
(2009)European Society of Cardiology Congress 2009. (Abstract # 84552)
B Hynes, Arun HS Kumar, S Weiss, J Schmeckpeper, K Martin, NM Caplice. (2009) Transforming growth factor beta and insulin like growth factor one play a key role in the beneficial paracrine effects of endothelial progenitor cells in myocardial salvage post infarction European Society of Cardiology Congress 2009. (Abstract # 84552) [Details]
(2009)Evaluating the effect of everoliums on cardiomyocyte apoptosis in both an in-vitro model of hypoxia and an in-vivo drug eluting stetting post myocardial infarction
B Hynes, Arun HS Kumar, S Weiss, J O’Sullivan, K Martin, G Murphy, NM Caplice. (2009) European Society of Cardiology Congress 2009. (Abstract # 86618) Evaluating the effect of everoliums on cardiomyocyte apoptosis in both an in-vitro model of hypoxia and an in-vivo drug eluting stetting post myocardial infarction [Details]
(2009)International Herbal Conference (Herbal Medicine-Evaluation of quality, efficiency and safety) 26th-28th Feb 2009. www.herbalconference2009.com. P26-37
Arun HS Kumar, Brian G Hynes, Mueen Ahmed KK. (2009) Natural products as regulators of progenitor cells: Role in cardiovascular regenerative medicine International Herbal Conference (Herbal Medicine-Evaluation of quality, efficiency and safety) 26th-28th Feb 2009. www.herbalconference2009.com. P26-37 [Details]
(2011)Atherosclerosis Thrombosis and Vascular Biology Conference. 28th-30th April 2011. Hilton, Chicago, Illinois, USA. (Abstract # 220)
Arun HS Kumar, Kenneth Martin, Noel M Caplice (2011) Deficiency of CX3CR1 Receptors Results in Formation of Leaky Microvessels in Plaque Atherosclerosis Thrombosis and Vascular Biology Conference. 28th-30th April 2011. Hilton, Chicago, Illinois, USA. (Abstract # 220) [Details]
(2011)Atherosclerosis Thrombosis and Vascular Biology Conference, 28th--‐30th April 2011. Hilton, Chicago, Illinois,USA
Pat Metharom, Kenneth Martin, Arun HS Kumar, Noel M Caplice. (2011) Pleiotropic Role for Monocyte C--‐fms Protein in Response to Vascular Injury:= Potential Therapeutic Target Atherosclerosis Thrombosis and Vascular Biology Conference, 28th--‐30th April 2011. Hilton, Chicago, Illinois,USA [Details]
(2011)American College of Cardiology, Winner Cardiovascular Pharmacology YIA
John F. O'Sullivan, Anne-Laure Leblond, Pat Metharom, Arun HS Kumar, Geraldine Kelly, Eva Hristova, Brian Hynes, Rosemary O'Connor, and Noel M. Caplice (2011) POTENT CARDIOPROTECTIVE EFFECTS OF LOW DOSE INSULIN-LIKE GROWTH FACTOR-1 (LD-IGF-1) TREATMENT POST MYOCARDIAL INFARCTION ARE MEDIATED THROUGH PHOSPHORYLATION OF THE IGF-1 RECEPTOR, GSK-3BETA INHIBITION AND SURVIVAL KINASE UPREGULATION- American College of Cardiology, Winner Cardiovascular Pharmacology YIA [Details]
(2011)Irish Cardiac Society, Winner YIA
John F O’Sullivan, M.D., Anne-Laure Leblond, PhD, Geraldine Kelly, BSc, Arun HS Kumar DVM, PhD, Pat Metharom, PhD, Chirlei K Büneker, PhD, Niki Alizadeh-Vikali, MSc, BHSc, Ivalina Hristova, BS, Brian G Hynes, M.D., Rosemary O’Connor, PhD, Noel M Caplice, (2011) Potent Long-term Cardioprotective Effects of Single Low Dose Insulin-like Growth Factor-1 (LD-IGF-1) Treatment Post Myocardial Infarction Irish Cardiac Society, Winner YIA [Details]

Abstract

 YearPublication
(2011)Potent Long-term Cardioprotective Effects of Single Low Dose Insulin-like Growth Factor-1 (LD-IGF-1) Treatment Post Myocardial Infarction.
O'Sullivan, JF,Leblond, AL,Kelly, G,Kumar, AHS,Metharom, P,Buneker, CK,Alizadeh-Vikali, N,Hristova, I,Hynes, BG,O'Connor, R,Caplice, NM (2011) Potent Long-term Cardioprotective Effects of Single Low Dose Insulin-like Growth Factor-1 (LD-IGF-1) Treatment Post Myocardial Infarction. Abstract [Details]
(2009)Endothelial Progenitor Cell Derived Conditioned Media Reduces In Vivo Cardiomyocyte Apoptosis Acting Through TGFB1 and IGF1.
Hynes, B,Kumar, AHS,Weiss, S,Schmeckpeper, J,Murphy, G,Martin, K,O'Sullivan, J,McCauley, S,Caplice, NM (2009) Endothelial Progenitor Cell Derived Conditioned Media Reduces In Vivo Cardiomyocyte Apoptosis Acting Through TGFB1 and IGF1. Abstract [Details]
(2011)Protection from collagen-induced arthritis in a CX3CR1 deficient mouse strain.
Murphy, G,Kumar, A,Shanahan, F,Harney, S,Molloy, M,Caplice, N (2011) Protection from collagen-induced arthritis in a CX3CR1 deficient mouse strain. Abstract [Details]
(2011)Analysis of public attitudes towards the use of autologous and allogenic cells in tissue engineered products for burns.
Clover, AJP,O'Neill, BL,Kumar, AHS (2011) Analysis of public attitudes towards the use of autologous and allogenic cells in tissue engineered products for burns. Abstract [Details]
(2011)POTENT CARDIOPROTECTIVE EFFECTS OF LOW DOSE INSULIN-LIKE GROWTH FACTOR-1 (LD-IGF-1) TREATMENT POST MYOCARDIAL INFARCTION ARE MEDIATED THROUGH PHOSPHORYLATION OF THE IGF-1 RECEPTOR, GSK-3BETA INHIBITION AND SURVIVAL KINASE UPREGULATION.
O'Sullivan, JF,Leblond, AL,Metharom, P,Kumar, AHS,Kelly, G,Hristova, E,Hynes, B,O'Connor, R,Caplice, NM (2011) POTENT CARDIOPROTECTIVE EFFECTS OF LOW DOSE INSULIN-LIKE GROWTH FACTOR-1 (LD-IGF-1) TREATMENT POST MYOCARDIAL INFARCTION ARE MEDIATED THROUGH PHOSPHORYLATION OF THE IGF-1 RECEPTOR, GSK-3BETA INHIBITION AND SURVIVAL KINASE UPREGULATION. Abstract [Details]
(2011)CX3CR1 DEFICIENCY RESULTS IN PROTECTION FROM COLLAGEN-INDUCED ARTHRITIS IN A TRANSGENIC MOUSE MODEL.
Murphy, G,Kumar, A,Shanahan, F,Harney, S,Molloy, M,Caplice, N (2011) CX3CR1 DEFICIENCY RESULTS IN PROTECTION FROM COLLAGEN-INDUCED ARTHRITIS IN A TRANSGENIC MOUSE MODEL. Abstract [Details]
(2011)Monocyte recruitment via the CX3CR1 receptor influences burn wound healing.
Clover, AJP,Kumar, AHS,Caplice, NM (2011) Monocyte recruitment via the CX3CR1 receptor influences burn wound healing. Abstract [Details]
(2012)Potent long-term cardioprotective effects of single low dose insulin-like growth factor-1 (LD-IGF-1) treatment post myocardial infarction.
O'sullivan, JF,Leblond, AL,Kelly, G,Kumar, AHS,Metharom, P,Buneker, CK,Alizadeh-Vikali, N,Hynes, BG,O'connor, R,Caplice, NM (2012) Potent long-term cardioprotective effects of single low dose insulin-like growth factor-1 (LD-IGF-1) treatment post myocardial infarction. Abstract [Details]

Professional Activities

Honours and Awards

 YearTitleAwarding Body
2012Science Foundation Ireland - TIDA Entrepreneurship training award (2011-2012) Science Foundation Ireland - Enterprise Ireland
2005Represented Indian embassy (Washington, USA) at the 55th Meeting of Nobel Prize Winners Indian embassy (Washington, USA)
2006PP Suriyakumari Gold Medal: Pharmacological Society (India) Pharmacological Society (India) (2005-2006)
1998Stood 3rd in the final grade list of DVM/BVSc with 91.5% as aggregate score Veterinary College, Bangalore, India.
1995Awarded Col., Robert Gabriel Scholarship of merit (Undergraduate Study) Ministry of Defence, India
2000Topped the MVSc final grade list with 90.7% as aggregate score (1998-2000). Veterinary College, Hyderabad, India
2000Indian Council of Agricultural Research Agriculatural Research (ICAR) ARS-NET Certified for Assistant Professorship in Pharmacology and Toxicology Indian Council of Agricultural Research Agriculatural Research Scientist Recruitment Board
2001University Grants Commission-CSIR NET - Certified for lectureship in Life Sciences University Grants Commission - Council for Scientific and Industrial Research: India
2004Awarded Council of Scientific and Industrial Research (CSIR)-Senior Research Fellowship in Pharmacology Council of Scientific and Industrial Research (CSIR): India
2003Young Scientist Award in Toxicology Society of Toxicology (India)
2004PC Dandiya prize (Young Scientist Award) in Preclinical Pharmacology Indian Pharmacological Society

Associations

 AssocationFunctionFrom / To
Sigma Aldrich Global advisory board member for Sigma Aldrich/
The Science Advisory Board Life Member/
European Society of Laboratory Animal Veterinarians Member/
Cardio Source Member/
Ion channel e-groups Member/
Indpharma group (e-group of pharmacologist of Indian Origin) Member/
Indian Society of Hypertension Member/
Indian Veterinary Association Life Member/
Karnataka Veterinary Association (India) Life Member/
Society of Toxicology (STOX) Life Member/

Employment

 EmployerPositionFrom / To
University College Cork, Cork, Ireland Senior Scientist (Cardiovascular Pharmacology and Medicine):01-JUN-06 /
University of Clinics Giessen, Rudolf-Buchheim-Institute For Pharmacology, Giessen, Germany Postdoctoral Scholar (In vivo & In vitro Pharmacology)01-MAR-04 / 01-JUN-06
MONASH University, Melbourne, Australia Scientist (In vivo & In vitro Pharmacology)01-JAN-06 / 31-MAY-06
National Institute of Pharmaceutical Education and Research (NIPER), Punjab, India CSIR Senior Research Fellow01-JUL-01 / 01-MAR-04
Torrent Research Centre (R & D division of Torrent Pharmaceuticals), Gujarat, India Scientist (Preclinical Drug Discovery)01-DEC-00 / 01-JUN-01

Education

 YearInstituionQualificationSubject
2009VetMed Team, Florida, U.S.A. CertificateBasic Concepts in Immunology, Canine Heart worm disease, Canine pain Management, Companion animal Dentistry 101, Companion animal Dentistry 102, Fecal diagnosis, Immunization, Zoonotic Diseases 101, Zoonotic Diseases 102.
2004National Institute of Pharmaceutical Education and Research (NIPER) PHDPharmacology
2000Veterinary College, ANGRAU, Hyderabad, India MDPharmacology & Toxicology
1998Veterinary College, UAS, Bangalore, India Veterinary Medical DoctorVeterinary Medicine and Animal Husbandary
1997The British Institutes, Mumbai, India DIPLOMABusiness Administration (DBA)
2009VetMed Team, Florida, USA CertificateVarious

Languages

 LanguageReadingWritingSpeaking
Sign Language BasicNoneBasic
German FunctionalNoneBasic
English FluentFluentFluent

Other Activities

 Description

Registered Veterinary Practitioner Karnataka Veterinary Council, India 

Certified Veterinary Practitioner by Veterinary Council of India 

Editor: Pharmacognosy Reviews.




Editor: Pharmacognosy Magazine.


Editor In Chief: Journal of Contradictory Results in Science. www.jcrsci.org


Certified by Agricultural Scientist Recruitment Board (Indian Council of Agricultural Research, India) for Assistant professorship in Pharmacology (Certificate No: 170480). This certificate is co-recognised by University Grants Commission (UGC) and Council of Scientific and Industrial Research (CSIR), India (Certificate No: 2-44/2000 (1) – EU.II). 


Editor: Pharmacognosy Research (Journal covering natural product drug discovery topics). 




Editor In Chief: Journal Natural Science Biology and Medicine. www.jnsbm.org



Teaching Activities

Teaching Interests

Mentoring and Teaching Skills



Seven years of experience in teaching and training UG, PG and PhD candidates (Veterinary, Pharmacy and Medicine) in the field of general physiology, pharmacology, Cardiovascular medicine/pharmacology and stem cells biology.



Student’s trained/supervised: PhD Students: 4, Masters students: 9, Medical (MD) students: 4, Technical/research assistants: 6



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Department of Medicine

Roinn na Sláinte

Clinical Sciences Building, Cork University Hospital , T12 EC8P

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