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4. Daniel Costello

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Biography

My current post is that of Consultant Neurologist with a subspecialty interest in Epilepsy at Cork University Hospital. I am also a Senior Lecturer in Neurology at University College Cork. My post involves commitment to clinical services, teaching, clinical research and administrative duties.

My clinical duties include General Neurology, Complex Epilepsy and Rapid Access Seizure Clinic. I also have outreach Epilepsy Clinics in the community for persons with intellectual disability in residential care. I am the Regional (HSE-South) Clinical Lead of the National Epilepsy Clinical Care Programme and I am the President of the Irish Chapter of the International League Against Epilepsy (ILAE) (2017-2021). . I supervise and mentor Epilepsy fellows. 

My research interests include  ‍

Research Interests

My overarching research interests include Epilepsy and Clinical Neurophysiology with a particular interest in clinical epileptology and in the technical, interpretive and clinical aspects of EEG. 

I am presently involved in the following active clinical research projects:

• EP0092 Phase 3 Study of Padsevonil as add-on therapy for refractory focal epilepsy.
• Epidemiological study on incidence of unprovoked seizures, new-onset epilepsy, provoked seizures and seizure mimics in Cork city & county
• Genetics of Epilepsy, particularly in setting of intellectual disability
• Natural history of Mesial Temporal Lobe Epilepsy, particularly Bitemporal epilepsy
• Intractable MRI-negative focal epilepsy
• Wireless EEG technologies
• NORSE syndrome (New Onset Refractory Status Epilepticus)

Previous studies include: 

• Phase II randomized, placebo-controlled, double-blind study of minocycline in the treatment of HIV-associated cognitive impairment; MGH.
• Phase II trial of surface neurostimulation (‘Neuropace’ device) for intractable partial epilepsy in adults; MGH.
• Multicenter randomised clinical trial for the treatment of Refractory Status Epilepticus; MGH.
• VOTE study [EP0076] 2017-8. Patient preference in epilepsy monotherapy- a non-interventional study of lacosamide and other anti-epileptic drugs in the the treatment of partial-onset seizures, including a discrete choice experiment. 
• Phase IV study. BASE study [EP0075] 2018-9. Brivaracetam and seizure reduction in Epilepsy- a 12-month non-interventional, post-marketing multicentre study to evaluate the effectiveness of Brivaracetam as adjunctive therapy in patients with epilepsy with partial-onset seizures in daily clinical practice.

Research Grants

	Project	Funding Body	Start Date	End Date	Award
	Use of a cell line expressing the neurotrophin GDF-5 to enhance the efficacy of transplanted dopaminergic neurones in a rat model of Parkinson’s disease	Health Research Board	01-SEP-00	31-AUG-01
	Clinical Fellowship in Epilepsy and Clinical Neurophysiology at the MGH	Other: Not Listed	01-JUL-04	30-DEC-05
	Clinical Fellowship in Advanced General Neurology at the MGH	Other: Not Listed	01-JUL-06	30-JUN-07

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Publications

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Peer Reviewed Journals

	Year	Publication
	(2018)	'The phenotype of bilateral hippocampal sclerosis and its management in “real life” clinical settings' Sen, A.,Dugan, P.,Perucca, P.,Costello, D.,Choi, H.,Bazil, C.,Radtke, R.,Andrade, D.,Depondt, C.,Heavin, S.,Adcock, J.,Pickrell, W. O.,McGinty, R.,Nascimento, F.,Smith, P.,Rees, M. I.,Kwan, P.,O'Brien, T. J.,Goldstein, D.,Delanty, N. (2018) 'The phenotype of bilateral hippocampal sclerosis and its management in “real life” clinical settings'. Epilepsia, 59 (7):1410-1420   [DOI] [Details]
	(2018)	'Clinical effectiveness of dual nicotine replacement therapy in planned hospital admissions to an epilepsy monitoring unit: An irish perspective' McGinty, R. N.,Goulding, D. M.,McCarthy, M. J.,Moloney, S. M.,Costello, D. J.,Plant, B. J. (2018) 'Clinical effectiveness of dual nicotine replacement therapy in planned hospital admissions to an epilepsy monitoring unit: An irish perspective'. Nicotine and Tobacco Research, 20 (5):656-658   [DOI] [Details]
	(2018)	'Real world experience with lacosamide monotherapy- a single center 1-year follow-up study' Maloney, E.,McGinty, R. N.,Costello, D. J. (2018) 'Real world experience with lacosamide monotherapy- a single center 1-year follow-up study'. Epilepsy Research, 142 :16-19   [DOI] [Details]
	(2017)	'PCDH19-related epilepsy: A rare but recognisable clinical syndrome in females' Lyons, S.,Marnane, M.,Reavey, E.,Williams, N.,Costello, D. (2017) 'PCDH19-related epilepsy: A rare but recognisable clinical syndrome in females'. Practical Neurology, 17 (4):314-317   [DOI] [Details]
	(2017)	'Economic analysis of an epilepsy outreach model of care in a university hospital setting' Maloney, E.,McGinty, R. N.,Costello, D. J. (2017) 'Economic analysis of an epilepsy outreach model of care in a university hospital setting'. Epilepsy and Behavior, 72 :178-181   [DOI] [Details]
	(2017)	'Long-term lacosamide retention—Real-world experience at a tertiary epilepsy center in Ireland' McGinty, R. N.,Costello, D. J. (2017) 'Long-term lacosamide retention—Real-world experience at a tertiary epilepsy center in Ireland'. Epilepsy and Behavior, 68 :141-145   [DOI] [Details]
	(2017)	'Investment in epilepsy monitoring units improves epilepsy care-experience in a regional neuroscience centre' McGinty, R. N.,Costello, D. J.,McNamara, B.,Kinirons, P.,Sweeney, B. J. (2017) 'Investment in epilepsy monitoring units improves epilepsy care-experience in a regional neuroscience centre'. Irish Medical Journal, 110 (7)   [Details]
	(2017)	'Occipital ulegyria causing epilepsy and visual impairment: an easily overlooked epilepsy syndrome' O'Connor, A.,Costello, D. J. (2017) 'Occipital ulegyria causing epilepsy and visual impairment: an easily overlooked epilepsy syndrome'. Epileptic Disorders, 19 (4):486-490   [DOI] [Details]
	(2017)	'Can syncope cause convulsive seizures in adults?' Kelly, D. M.,Costello, D. J. (2017) 'Can syncope cause convulsive seizures in adults?'. Clinical Autonomic Research, 27 (4):283-287   [DOI] [Details]
	(2016)	'Elite athletes and epilepsy' McGinty, R. N.,Costello, D. J. (2016) 'Elite athletes and epilepsy'. Epilepsia, 57 (6):1009-1010   [DOI] [Details]
	(2016)	'Hereditary leukoencephalopathy with axonal spheroids: A spectrum of phenotypes from CNS vasculitis to parkinsonism in an adult onset leukodystrophy series' Lynch, D. S.,Jaunmuktane, Z.,Sheerin, U. M.,Phadke, R.,Brandner, S.,Milonas, I.,Dean, A.,Bajaj, N.,McNicholas, N.,Costello, D.,Cronin, S.,McGuigan, C.,Rossor, M.,Fox, N.,Murphy, E.,Chataway, J.,Houlden, H. (2016) 'Hereditary leukoencephalopathy with axonal spheroids: A spectrum of phenotypes from CNS vasculitis to parkinsonism in an adult onset leukodystrophy series'. Journal of Neurology, Neurosurgery and Psychiatry, 87 (5):512-519   [DOI] [Details]
	(2015)	'Severe bilateral optic neuritis post hepatitis A virus (HAV) and typhoid fever vaccination' O'Dowd, S.,Bafiq, R.,Ryan, A.,Cullinane, A.,Costello, D. (2015) 'Severe bilateral optic neuritis post hepatitis A virus (HAV) and typhoid fever vaccination'. Journal of the Neurological Sciences, 357 (1-2):300-301   [DOI] [Details]
	(2014)	'Sexual dimorphism in clinical neurology - Predictors of successful lumbar puncture in an expanding population' Power, S. P.,Costello, D. J.,Tobin, W. O. (2014) 'Sexual dimorphism in clinical neurology - Predictors of successful lumbar puncture in an expanding population'. Obesity, 22 (7):1747-1749   [DOI] [Details]
	(2014)	'Assessment of the usefulness of magnetic resonance brain imaging in patients presenting with acute seizures' Olszewska, D. A.,Costello, D. J. (2014) 'Assessment of the usefulness of magnetic resonance brain imaging in patients presenting with acute seizures'. Irish Journal of Medical Science, 183 (4):621-624   [DOI] [Details]
	(2013)	'Anti-NMDA receptor encephalitis: A cause of acute psychosis and catatonia' Ryan, S. A.,Costello, D. J.,Cassidy, E. M.,Brown, G.,Harrington, H. J.,Markx, S. (2013) 'Anti-NMDA receptor encephalitis: A cause of acute psychosis and catatonia'. Journal of Psychiatric Practice, 19 (2):157-161   [DOI] [Details]
	(2013)	'Heritability of Subcortical Volumetric Traits in Mesial Temporal Lobe Epilepsy' Alhusaini, S.,Scanlon, C.,Ronan, L.,Maguire, S.,Meaney, J. F.,Fagan, A. J.,Boyle, G.,Borgulya, G.,Iyer, P. M.,Brennan, P.,Costello, D.,Chaila, E.,Fitzsimons, M.,Doherty, C. P.,Delanty, N.,Cavalleri, G. L. (2013) 'Heritability of Subcortical Volumetric Traits in Mesial Temporal Lobe Epilepsy'. PLoS One, 8 (4)   [DOI] [Details]
	(2012)	'Transplantation of novel human GDF5-expressing CHO cells is neuroprotective in models of Parkinson's disease' Costello, D. J.,O'Keeffe, G. W.,Hurley, F. M.,Sullivan, A. M. (2012) 'Transplantation of novel human GDF5-expressing CHO cells is neuroprotective in models of Parkinson's disease'. Journal of Cellular and Molecular Medicine, 16 (10):2451-2460   [DOI] [Details]
	(2011)	'Mutation of SCARB2 in a patient with progressive myoclonus epilepsy and demyelinating peripheral neuropathy' Dibbens, L. M.,Karakis, I.,Bayly, M. A.,Costello, D. J.,Cole, A. J.,Berkovic, S. F. (2011) 'Mutation of SCARB2 in a patient with progressive myoclonus epilepsy and demyelinating peripheral neuropathy'. Archives of Neurology, 68 (6):812-813   [DOI] [Details]
	(2011)	'Clinical and EEG features of seizures in adults with down syndrome' Lefter, S.,Costello, D. J.,McNamara, B.,Sweeney, B. (2011) 'Clinical and EEG features of seizures in adults with down syndrome'. Journal of Clinical Neurophysiology, 28 (5):469-473   [DOI] [Details]
	(2011)	'Case 18-2011: A 35-year-old HIV-positive woman with headache and altered mental status' Costello, D. J.,Gonzalez, R. G.,Frosch, M. P. (2011) 'Case 18-2011: A 35-year-old HIV-positive woman with headache and altered mental status'. New England Journal of Medicine, 364 (24):2343-2352   [DOI] [Details]
	(2010)	'A 29-year-old woman with headache, fever, right leg numbness, and dysphagia' Stone, J. H.,Papaliodis, G. N.,Costello, D. J. (2010) 'A 29-year-old woman with headache, fever, right leg numbness, and dysphagia'. Arthritis care & research, 62 (2):283-290   [DOI] [Details]
	(2009)	'How seizure detection by continuous electroencephalographic monitoring affects the prescribing of antiepileptic medications' Kilbride, R. D.,Costello, D. J.,Chiappa, K. H. (2009) 'How seizure detection by continuous electroencephalographic monitoring affects the prescribing of antiepileptic medications'. Archives of Neurology, 66 (6):723-728   [DOI] [Details]
	(2009)	'Efficacy of lamotrigine in disabling myoclonus in a patient with an mtDNA a3243g mutation' Costello, D. J.,Sims, K. B. (2009) 'Efficacy of lamotrigine in disabling myoclonus in a patient with an mtDNA a3243g mutation'. Neurology, 72 (14):1279-1280   [DOI] [Details]
	(2009)	'Case 1-2009: A 57-year-old man with progressive cognitive decline' Costello, D. J.,Eichler, F. S.,Grant, P. E.,Auluck, P. K. (2009) 'Case 1-2009: A 57-year-old man with progressive cognitive decline'. New England Journal of Medicine, 360 (2):171-181   [DOI] [Details]
	(2009)	'Leukodystrophies classification, diagnosis, and treatment' Costello, D. J.,Eichler, A. F.,Eichler, F. S. (2009) 'Leukodystrophies classification, diagnosis, and treatment'. Neurologist, 15 (6):319-328   [DOI] [Details]
	(2009)	'Progressive myoclonus epilepsy with demyelinating peripheral neuropathy and preserved intellect: A novel syndrome' Costello, D. J.,Chiappa, K. H.,Siao, P. (2009) 'Progressive myoclonus epilepsy with demyelinating peripheral neuropathy and preserved intellect: A novel syndrome'. Archives of Neurology, 66 (7):898-901   [DOI] [Details]
	(2009)	'Infantile spasms in tuberous sclerosis complex: Prognostic utility of EEG' Muzykewicz, D. A.,Costello, D. J.,Halpern, E. F.,Thiele, E. A.; (2009) 'Infantile spasms in tuberous sclerosis complex: Prognostic utility of EEG'. Epilepsia, 50 (22):290-296290   [Details]
	(2009)	'Associations between electroencephalographic and magnetic resonance imaging findings in tuberous sclerosis complex' Gallagher, A.,Chu-Shore, C. J.,Montenegro, M. A.,Major, P.,Costello, D. J.,Lyczkowski, D. A.,Muzykewicz, D.,Doherty, C.,Thiele, E. A.; (2009) 'Associations between electroencephalographic and magnetic resonance imaging findings in tuberous sclerosis complex'. Epilepsy Research, 87 (2-32-3):197-202197   [Details]
	(2009)	'Consideration of epilepsy surgery in adults should be independent of age' Costello, D. J.,Shields, D. C.,Cash, S. S.,Eskandar, E. N.,Cosgrove, G. R.,Cole, A. J.; (2009) 'Consideration of epilepsy surgery in adults should be independent of age'. Clinical Neurology and Neurosurgery, 111 (33):240-245240   [Details]
	(2009)	'Cryptogenic New Onset Refractory Status Epilepticus (NORSE) in adults-Infectious or not?' Costello, D. J.,Kilbride, R. D.,Cole, A. J.; (2009) 'Cryptogenic New Onset Refractory Status Epilepticus (NORSE) in adults-Infectious or not?'. Journal of the Neurological Sciences, 277 (1-21-2):26-3126   [Details]
	(2009)	'Periodic epileptiform discharges in hypoxic encephalopathy: BiPLEDs and GPEDs as a poor prognosis for survival' San-juan, O. D.,Chiappa, K. H.,Costello, D. J.,Cole, A. J. (2009) 'Periodic epileptiform discharges in hypoxic encephalopathy: BiPLEDs and GPEDs as a poor prognosis for survival'. Seizure, 18 (5):365-368   [DOI] [Details]
	(2009)	'Prognostic implications of periodic epileptiform discharges' Orta, D. S. J.,Chiappa, K. H.,Quiroz, A. Z.,Costello, D. J.,Cole, A. J. (2009) 'Prognostic implications of periodic epileptiform discharges'. Archives of Neurology, 66 (8):985-991   [DOI] [Details]
	(2007)	'In reply [4]' McCabe, D. J. H.,Chaila, E. C.,Delanty, N.,Costello, D.,Murphy, R. P. (2007) 'In reply [4]'. Archives of Neurology, 64 (8)   [Details]
	(2007)	'Laboratory investigation of fungal infections of the central nervous system' Davis, J.,Costello, D.,Venna, N. (2007) 'Laboratory investigation of fungal infections of the central nervous system'. Neurology India, 55 (3):233-240   [Details]
	(2007)	'Stereotactic cortical resection in non-lesional extra-temporal partial epilepsy' Shields, D. C.,Costello, D. J.,Gale, J. T.,Hoch, D. B.,Eskandar, E. N.; (2007) 'Stereotactic cortical resection in non-lesional extra-temporal partial epilepsy'. European Journal of Neurology, 14 :1186-11881186   [Details]
	(2007)	'Analytic review: Treatment of acute seizures and status epilepticus' Costello, D. J.,Cole, A. J. (2007) 'Analytic review: Treatment of acute seizures and status epilepticus'. Journal of Intensive Care Medicine, 22 (6):319-347   [DOI] [Details]
	(2007)	'HIV infection with immunodeficiency presenting with subacute cognitive decline: Recent illustrative cases' Costello, D.,Davis, J.,Venna, N. (2007) 'HIV infection with immunodeficiency presenting with subacute cognitive decline: Recent illustrative cases'. CNS Spectrums, 12 (11):842-850   [DOI] [Details]
	(2006)	'Efficacy of surgical treatment of de novo, adult-onset, cryptogenic, refractory focal status epilepticus' Costello, D. J.,Simon, M. V.,Eskandar, E. N.,Frosch, M. P.,Henninger, H. L.,Chiappa, K. H.,Cole, A. J. (2006) 'Efficacy of surgical treatment of de novo, adult-onset, cryptogenic, refractory focal status epilepticus'. Archives of Neurology, 63 (6):895-901   [DOI] [Details]
	(2006)	'Broadening the phenotype of childhood-onset dopa-responsive dystonia' Chaila, E. C.,McCabe, D. J. H.,Delanty, N.,Costello, D. J.,Murphy, R. P.; (2006) 'Broadening the phenotype of childhood-onset dopa-responsive dystonia'. Archives of Neurology, 63 (88):1185-11881185   [Details]
	(2005)	'Audit of an inpatient neurology consultation service in a tertiary referral centre: Value of the consulting neurologist' Costello, D. J.,Renganathan, R.,O'Haire, A.,Murray, B.,Lynch, T. (2005) 'Audit of an inpatient neurology consultation service in a tertiary referral centre: Value of the consulting neurologist'. Irish Medical Journal, 98 (5):134-137   [Details]
	(2004)	'Fatal presentation of ornithine transcarbamylase deficiency in a 62-year-old man and family studies' Rohininath, T.,Costello, D. J.,Lynch, T.,Monavari, A.,Tuchman, M.,Treacy, E. P.; (2004) 'Fatal presentation of ornithine transcarbamylase deficiency in a 62-year-old man and family studies'. Journal of Inherited Metabolic Disease, 27 (22):285-288285   [Details]
	(2004)	'Neuroprotective effects of delayed administration of growth/ differentiation factor-5 in the partial lesion model of Parkinson's disease' Hurley, F. M.,Costello, D. J.,Sullivan, A. M. (2004) 'Neuroprotective effects of delayed administration of growth/ differentiation factor-5 in the partial lesion model of Parkinson's disease'. Experimental Neurology, 185 (2):281-289   [DOI] [Details]
	(2004)	'Oxidative injury in epilepsy: Potential for antioxidant therapy?' Costello, D. J.,Delanty, N. (2004) 'Oxidative injury in epilepsy: Potential for antioxidant therapy?'. Expert Review of Neurotherapeutics, 4 (3):541-553   [DOI] [Details]

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Conference Paper

	Year	Publication
	(2017)	Comparison of electrode technologies for dry and portable EEG acquisition. O'Sullivan, M.,Pena, J. P.,Bocchino, A.,O'Mahony, C.,Costello, D.,Popovici, E.,Temko, A. (2017) Comparison of electrode technologies for dry and portable EEG acquisition. Conference Paper   [DOI] [Details]
	(2011)	Parallel artefact rejection for epileptiform activity detection in routine EEG. Kelleher, D.,Temko, A.,Orregan, S.,Nash, D.,McNamara, B.,Costello, D.,Marnane, W. P. (2011) Parallel artefact rejection for epileptiform activity detection in routine EEG. Conference Paper   [DOI] [Details]

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Professional Activities

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Professional Associations

	Association	Function	From / To
	Register of Medical Specialists, Division of Neurology	2005	/
	Register of Medical Practitioners	1996	/

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Employment

	Employer	Position	From / To
	Cork University Hospital	Research Fellowship	01-JUL-00 / 30-JUN-02
	St Vincent’s University Hospital	Fellow in Epilepsy & Neurophysiology	01-JUL-04 / 30-JUN-06
	Massachusetts General Hospital, Boston	Fellow in Advanced General Neurology	01-JUL-06 / 30-JUL-07
	Cork University Hospital	Internship & General Medicine Training	01-JUL-96 / 30-JUN-99
	Massachusetts General Hospital, Boston	Consultant Neurologist & Epileptologist	01-JUL-07 / 30-SEP-09
	Cork University Hospital	Specialist Registrar in Neurology	01-JUN-99 / 30-MAY-05

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Outreach Activities

	Description
	Community Epilepsy Clinic for persons in care with learning disabilities.

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Teaching Activities

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Teaching Interests

Currently, I participate in the following educational activities:

• regular teaching of medical students in the clinic, during ward rounds, in formal didactic lectures and in scheduled bedside teaching sessions (90 minute sessions, twice per month)
• formal examination of the clinical skills of medical students
• I developed a lecture series using a 'problem-based learning' approach to teaching Neurology residents about common Neurological scenarios
• regular teaching of Neurology residents and Epilepsy fellows in the areas of clinical epilepsy, EEG interpretation and General Neurology.
• weekly supervision of Neurology resident and Epilepsy fellow clinics