Lecturer and Funded Investigator
Biochemistry & Cell Biology
Room 2.10
School of Biochemistry & Cell Biology
BioScience Institute, University College Cork
Cork

T: +353-21-490-1302
E: k.nally@ucc.ie

Dr. Ken Nally is a recently appointed Lecturer in the School of Biochemistry and Cell Biology and is a Funded Investigator in the Alimentary Pharmabiotic Centre (APC), University Collge Cork (UCC). Dr. Nally has a BSc. in Biochemistry from the National University of Ireland, Galway (NUIG) and a PhD in Microbiology from UCC. He has spent the last 10 years working in the area of Inflammation discovery research initially as a postdoctoral fellow after obtaining a Career Development Fellowship (HRB, 2003 - 2006) and thereafter as a group leader in the APC, UCC. The APC is a world leading research centre in the area of gut microbiota and gut health and during this phase of his career (2006-2012), Dr. Nally directed a 5 year research collaboration between the APC and the pharmaceutical company, GlaxoSmithKline Ltd. (GSK) in the areas Inflammatory Bowel Disease (IBD) early drug discovery research, inflammation, leukocyte trafficking, miRNA and epigenetic regulation of inflammatory gene expression. Dr. Nally was recently awarded an SFI Career Development Award grant (2014) to expand his research activities in these areas. His research group takes a functional genomics approach to discover the fundamental mechanisms underpinning host-microbe interactions, cell death induced by Th1 inflammatory cytokines, cross-talk between inflammatory and oncogenic (RTK) signaling pathways and epigenetic regulation of inflammatory, anti-microbial and cell death gene expression.

Research Interests

Host-Microbe Interaction, Inflammation, and Cancer Biology


(1) Host-Microbe interactions in health and inflammatory disease
(2) Immunopathology in inflammatory disease and cancer
(3) Mechanisms underpinning cross-talk and synergism between inflammatory signalling pathways
(4) Specific focus on Interferon (IFN) and Tumor Necrosis Factor (TNF) signalling pathways
(5) Crosstalk between inflammatory and oncogenic signalling pathways
(6) Epigenetic mechanisms underpinning regulation of inflammatory, anti-viral and oncogenic gene expression
(7) Functional genomics analysis of inflammatory, cell survival and cell death pathways
(8) Discovery of cancer cell intrinsic tumour suppressor mechanisms underpinning immune-mediated suppression of cancer

My research interests are in the areas of Host-Microbe Interaction, Inflammation and Cancer Biology. My group is exploring the molecular and cellular mechanisms underpinning the role of the immune system in host recognition of microbes, chronic inflammatory diseases such as Inflammatory Bowel Disease (IBD), type I diabetes and colon cancer. In terms of IBD and colon cancer, we are particularly interested in how the relative sensitivity and resistance of intestinal epithelial cells and colon cancer cells to immune-mediated apoptosis contributes to disease pathogenesis. The molecular mechanisms – signal transduction, transcriptional regulation and epigenetic - underpinning the regulation of gene expression in response to inflammatory stimuli in immune, non-immune cells and cancer cells and how this contributes to disease pathogenesis is the main focus of our research. Specifically, we have an interest in understanding how the synergistic interactions between IFN-gamma and other inflammatory stimuli such as LPS, IL-1beta and TNF-alpha both in terms of their overall effect on inflammatory gene expression and also cell fate decisions contribute to pathogenesis in diseases such as IBD, type I diabetes and other inflammatory conditions.  It is well appreciated that in IBD and type I diabetes, pro-inflammatory cytokines (IFN-gamma, IL-1beta and TNF-alpha) induce the death of epithelial cells thereby compromising the function of the gut and the pancreas respectively. Currently, in the context of collaborations with academic and pharmaceutical groups we are investigating the possible roles of microRNAs and epigenetic modifiers such as chromatin modifying enzymes – histone methyltransferases and histone demethylases - in regulating inflammatory gene expression and cell fate decisions in response to these  and other stimuli. We use a combination of in vitro cell and molecular biology based approaches, functional genomics approaches, in vivo based animal models of inflammation, inflammation linked colon cancer and human biopsy tissue to investigate basic mechanisms of disease with a focus on inflammatory bowel disease. In addition we use these various systems for drug target identification, drug target validation studies and for pre-clinical profiling of novel drug candidates for efficacy in the setting of chronic intestinal inflammation. We also have ongoing active research projects in the areas of host microbe interactions with a particular interest in the interaction of host cells with gut commensal bacteria.

Overall goals of my research activities are

(i)  To identify and progress new pharmacological approaches for treatment of inflammation and inflammation triggered tissue damage

(ii) To identify novel molecular targets in cancer cells which would sensitise cancer cells to immune-mediated cell death

(iii) To identify mechanisms facilitating the conversion of endogenous TNF-alpha from a tumour promoter to a tumour suppressor in human cancer


 

Research Grants

 ProjectFunding
Body
Start DateEnd DateAward
Investigation of the expression and function of the Type 1 interferon Pathway in irritable bowel syndrome.Health Research Board10-JUN-1302-AUG-13€2,000.00
SFI 12/RC/2273 Spoke 4A Host Microbe DialogueScience Foundation of Ireland01-JUN-1331-MAY-19€991,907.00
Evaluation of altered Pattern Recognition Receptor (PRR) expression as a possible biomarker of disease in Ulcerative Colitis.Health Research Board13-JUN-1105-AUG-11€2,000.00
[HRB PD/2003/14] {Nally Dr. K} NHealth Research Board01-OCT-0330-SEP-06€182,946.00
Identification of the Molecular Pathways that mediate Cytokine induced Immunopahology of the Gut Epithelium.Science Foundation of Ireland01-SEP-1431-AUG-18€648,643.00
purchase of a VIAFLOW 384/96 Channel Pipetting System.Miscellaneous01-OCT-1330-SEP-14€12,000.00

Peer Reviewed Journals

YearPublication
(2014)'Disturbance of the gut microbiota in early-life selectively affects visceral pain in adulthood without impacting cognitive or anxiety-related behaviors in male rats'
O'Mahony SM, Felice VD, Nally K, Savignac HM, Claesson MJ, Scully P, Woznicki J, Hyland NP, Shanahan F, Quigley EM, Marchesi JR, O'Toole PW, Dinan TG, Cryan JF (2014) 'Disturbance of the gut microbiota in early-life selectively affects visceral pain in adulthood without impacting cognitive or anxiety-related behaviors in male rats'. Neuroscience, 277C :885-901 [DOI] [Details]
(2013)'Natural Killer Cells Protect against Mucosal and Systemic Infection with the Enteric Pathogen Citrobacter rodentium'
Hall, LJ,Murphy, CT,Hurley, G,Quinlan, A,Shanahan, F,Nally, K,Melgar, S (2013) 'Natural Killer Cells Protect against Mucosal and Systemic Infection with the Enteric Pathogen Citrobacter rodentium'. Infection and Immunity, 81 :460-469 [DOI] [Details]
(2013)'Bcl-3 deficiency protects against dextran-sodium sulphate-induced colitis in the mouse'
O'Carroll C, Moloney G, Hurley G, Melgar S, Brint E, Nally K, Nibbs RJ, Shanahan F, Carmody RJ (2013) 'Bcl-3 deficiency protects against dextran-sodium sulphate-induced colitis in the mouse'. Clinical and Experimental Immunology, 173 (2):332-342 [DOI] [Details]
(2013)'Concept for a rapid point-of-care calprotectin diagnostic test for diagnosis and disease activity monitoring in patients with inflammatory bowel disease: Expert clinical opinion'
Rogler, G,Aldeguer, X,Kruis, W,Lasson, A,Mittmann, U,Nally, K,Peyrin-Biroulet, L,Schoepfer, A,Vatn, M,Vavricka, S,Logan, R (2013) 'Concept for a rapid point-of-care calprotectin diagnostic test for diagnosis and disease activity monitoring in patients with inflammatory bowel disease: Expert clinical opinion'. Journal Of Crohns & Colitis, 7 :670-677 [DOI] [Details]
(2013)'Identification of TLR10 as a Key Mediator of the Inflammatory Response to Listeria monocytogenes in Intestinal Epithelial Cells and Macrophages'
Regan, T,Nally, K,Carmody, R,Houston, A,Shanahan, F,MacSharry, J,Brint, E (2013) 'Identification of TLR10 as a Key Mediator of the Inflammatory Response to Listeria monocytogenes in Intestinal Epithelial Cells and Macrophages'. Journal of immunology (Baltimore, Md. : 1950), 191 :6084-6092 [DOI] [Details]
(2013)'Natural killer cells protect mice from DSS-induced colitis by regulating neutrophil function via the NKG2A receptor'
Hall, L. J.,Murphy, C. T.,Quinlan, A.,Hurley, G.,Shanahan, F.,Nally, K.,Melgar, S. (2013) 'Natural killer cells protect mice from DSS-induced colitis by regulating neutrophil function via the NKG2A receptor'. Mucosal Immunol, 6 (55):1016-10261016 Globe icon [Details]
(2013)'TL1A/TNFSF15 directly induces proinflammatory cytokines, including TNF alpha, from CD3+CD161+T cells to exacerbate gut inflammation'
Jin, S.,Chin, J.,Seeber, S.,Niewoehner, J.,Weiser, B.,Beaucamp, N.,Woods, J.,Murphy, C.,Fanning, A.,Shanahan, F.,Nally, K.,Kajekar, R.,Salas, A.,Planell, N.,Lozano, J.,Panes, J.,Parmar, H.,DeMartino, J.,Narula, S.,Thomas-Karyat, D. A. (2013) 'TL1A/TNFSF15 directly induces proinflammatory cytokines, including TNF alpha, from CD3+CD161+T cells to exacerbate gut inflammation'. Mucosal Immunol, 6 (55):886-899886 Globe icon [Details]
(2012)'Shining a Light on Intestinal Traffic'
Murphy, C. T.,Nally, K.,Shanahan, F.,Melgar, S. (2012) 'Shining a Light on Intestinal Traffic'. Clin Dev Immunol, Globe icon [Details]
(2012)'Differential intestinal M-cell gene expression response to gut commensals'
Lapthorne, S.,MacSharry, J.,Scully, P.,Nally, K.,Shanahan, F. (2012) 'Differential intestinal M-cell gene expression response to gut commensals'. Immunology, 136 (33):312-324312 Globe icon [Details]
(2012)'The Sphingosine-1-Phosphate Analogue FTY720 Impairs Mucosal Immunity and Clearance of the Enteric Pathogen Citrobacter rodentium'
Murphy, C. T.,Hall, L. J.,Hurley, G.,Quinlan, A.,MacSharry, J.,Shanahan, F.,Nally, K.,Melgar, S. (2012) 'The Sphingosine-1-Phosphate Analogue FTY720 Impairs Mucosal Immunity and Clearance of the Enteric Pathogen Citrobacter rodentium'. Infect Immun, 80 (88):2712-27232712 Globe icon [Details]
(2012)'Bifidobacterial surface-exopolysaccharide facilitates commensal-host interaction through immune modulation and pathogen protection'
Fanning, S.,Hall, L. J.,Cronin, M.,Zomer, A.,MacSharry, J.,Goulding, D.,Motherway, M. O.,Shanahan, F.,Nally, K.,Dougan, G.,van Sinderen, D. (2012) 'Bifidobacterial surface-exopolysaccharide facilitates commensal-host interaction through immune modulation and pathogen protection'. Proc Natl Acad Sci U S A, 109 (66):2108-132108 Globe icon [Details]
(2012)'Mechanism of protection of transepithelial barrier function by Lactobacillus salivarius: strain dependence and attenuation by bacteriocin production'
Miyauchi, E.,O'Callaghan, J.,Butto, L. F.,Hurley, G.,Melgar, S.,Tanabe, S.,Shanahan, F.,Nally, K.,O'Toole, P. W. (2012) 'Mechanism of protection of transepithelial barrier function by Lactobacillus salivarius: strain dependence and attenuation by bacteriocin production'. American Journal of Physiology-Gastrointestinal and Liver Physiology, 303 (99) Globe icon [Details]
(2012)'Influence of Adhesion and Bacteriocin Production by Lactobacillus salivarius on the Intestinal Epithelial Cell Transcriptional Response'
O'Callaghan, J,Butto, LF,MacSharry, J,Nally, K,O'Toole, PW (2012) 'Influence of Adhesion and Bacteriocin Production by Lactobacillus salivarius on the Intestinal Epithelial Cell Transcriptional Response'. Applied and Environmental Microbiology, 78 :5196-5203 [DOI] [Details]
(2012)'Characterization of Pro-Inflammatory Flagellin Proteins Produced by Lactobacillus ruminis and Related Motile Lactobacilli'
Neville, BA,Forde, BM,Claesson, MJ,Darby, T,Coghlan, A,Nally, K,Ross, RP,O'Toole, PW (2012) 'Characterization of Pro-Inflammatory Flagellin Proteins Produced by Lactobacillus ruminis and Related Motile Lactobacilli'. Plos One, 7 [DOI] [Details]
(2011)'Induction and Activation of Adaptive Immune Populations During Acute and Chronic Phases of a Murine Model of Experimental Colitis'
Hall, L. J.,Faivre, E.,Quinlan, A.,Shanahan, F.,Nally, K.,Melgar, S. (2011) 'Induction and Activation of Adaptive Immune Populations During Acute and Chronic Phases of a Murine Model of Experimental Colitis'. Dig Dis Sci, 56 (11):79-8979 Globe icon [Details]
(2010)'Technical Advance: Function and efficacy of an alpha(4)-integrin antagonist using bioluminescence imaging to detect leukocyte trafficking in murine experimental colitis'
Murphy, C. T.,Moloney, G.,MacSharry, J.,Haynes, A.,Faivre, E.,Quinlan, A.,McLean, P. G.,Lee, K.,O'Mahony, L.,Shanahan, F.,Melgar, S.,Nally, K. (2010) 'Technical Advance: Function and efficacy of an alpha(4)-integrin antagonist using bioluminescence imaging to detect leukocyte trafficking in murine experimental colitis'. J Leukoc Biol, 88 (66):1271-12781271 Globe icon [Details]
(2010)'Down-regulation of p38 mitogen-activated protein kinase activation and proinflammatory cytokine production by mitogen-activated protein kinase inhibitors in inflammatory bowel disease'
Docena, G.,Rovedatti, L.,Kruidenier, L.,Fanning, A.,Leakey, N. A.,Knowles, C. H.,Lee, K.,Shanahan, F.,Nally, K.,McLean, P. G.,Di Sabatino, A.,MacDonald, T. T. (2010) 'Down-regulation of p38 mitogen-activated protein kinase activation and proinflammatory cytokine production by mitogen-activated protein kinase inhibitors in inflammatory bowel disease'. Clin Exp Immunol, 162 (11):108-15108 Globe icon [Details]
(2010)'Use of bioluminescence imaging to track neutrophil migration and its inhibition in experimental colitis'
Murphy, C. T.,Moloney, G.,Hall, L. J.,Quinlan, A.,Faivre, E.,Casey, P.,Shanahan, F.,Melgar, S.,Nally, K. (2010) 'Use of bioluminescence imaging to track neutrophil migration and its inhibition in experimental colitis'. Clin Exp Immunol, 162 (11):188-196188 Globe icon [Details]
(2005)'Targeting the Fas/Fas ligand pathway in cancer'
O'Brien, D. I.,Nally, K.,Kelly, R. G.,O'Connor, T. M.,Shanahan, F.,O'Connell, J. (2005) 'Targeting the Fas/Fas ligand pathway in cancer'. Expert Opin Ther Targets, 9 (55):1031-10441031 Globe icon [Details]
(2002)'Type I insulin-like growth factor receptor expression on colorectal adenocarcinoma cell lines is decreased in response to the chemopreventive agent N-acetyl-L-cysteine'
Kelly, R. G.,Nally, K.,Shanahan, F.,O'Connell, J. (2002) 'Type I insulin-like growth factor receptor expression on colorectal adenocarcinoma cell lines is decreased in response to the chemopreventive agent N-acetyl-L-cysteine'. Cell Signaling, Transcription, and Translation as Therapeutic Targets, 973 :555-558555 Globe icon [Details]
(2000)'Interferon-gamma sensitizes colonic epithelial cell lines to physiological and therapeutic inducers of colonocyte apoptosis'
O'connell, J.,Bennett, M. W.,Nally, K.,O'Sullivan, G. C.,Collins, J. K.,Shanahan, F. (2000) 'Interferon-gamma sensitizes colonic epithelial cell lines to physiological and therapeutic inducers of colonocyte apoptosis'. Journal Of Cellular Physiology, 185 (33):331-338 Globe icon [Details]
(2000)'Altered mechanisms of apoptosis in colon cancer: Fas resistance and counterattack in the tumor-immune conflict'
O'connell, J.,Bennett, M. W.,Nally, K.,Houston, A.,O'Sullivan, G. C.,Shanahan, F. (2000) 'Altered mechanisms of apoptosis in colon cancer: Fas resistance and counterattack in the tumor-immune conflict'. Colorectal Cancer: New Aspects Of Molecular Biology And Immunology And Their Clinical Applicationscolorectal Cancer: New Aspects Of Molecular Biology And Immunology And Their Clinical Applications, 910 :178-195 Globe icon [Details]

Conference Publications

YearPublication
(2012)National Conference 2012
Kennedy, B.,Kennedy, M. P.,Plant, B. J.,Henry, M. T.,O'Driscoll, M.,Maher, M.,Nally, K.,Shanahan, F.,Curran, D. R.,O'Connor, T. M. (2012) Bone Marrow and Peripheral Blood Derived CD14(+) Cells as Agents of Tissue Remodelling in Idiopathic Pulmonary Fibrosis National Conference 2012 Globe icon [Details]
(2012)DDW 2012; Gastroenterology
Fanning, A.,Moloney, G.,MacSharry, J.,Ambrose, M.,Prinjha, R.,Lee, K.,Quigley, E. M.,Shanahan, F.,Melgar, S.,Nally, K. (2012) Differential Expression of Epigenetic Modifier Genes in Inflammatory Bowel Disease Colonic Tissue-PRDM1 and PRDM8 are up-Regulated in Active Ulcerative Colitis DDW 2012; Gastroenterology Globe icon [Details]
(2012)DDW 2012; Gastroenterology
Beltran, C.,Fanning, A.,Moloney, G.,Grenham, S.,Heuston, S.,Melgar, S.,Nally, K.,Cryan, J. F.,Dinan, T. G.,Quigley, E. M. (2012) The Role of IL-9/Il9r in Irritable Bowel Syndrome DDW 2012; Gastroenterology Globe icon [Details]
(2012)DDW 2012; Gastroenterology
Moloney, G.,Fanning, A.,Mac Sharry, J.,Hall, L. J.,Shanahan, F.,Quigley, E. M.,Melgar, S.,Nally, K. (2012) Altered Expression and Activation of the CXCR3/CXCL10 Chemokine System in Irritable Bowel Syndrome (IBS) Mucosal Biopsy Tissue DDW 2012; Gastroenterology Globe icon [Details]
(2012)DDW 2012; Gastroenterology
Fanning, A.,Moloney, G.,MacSharry, J.,Ambrose, M.,Quigley, E. M.,Shanahan, F.,Melgar, S.,Nally, K. (2012) Elevated Expression of the Cytosolic DNA Sensors AIM2 and ZBP1/DAI in Active Ulcerative Colitis but Not Crohn's Disease Colonic Tissue DDW 2012; Gastroenterology Globe icon [Details]
(2012)DDW 2012; Gastroenterology
Ambrose, M.,Moloney, G.,Heuston, S.,Rahman, A.,Davies, J. M.,Murphy, C.,Hurley, G.,Quinlan, A.,Karras, J.,Hessel, E. M.,Prinjha, R.,Lee, K.,Hyland, N. P.,Shanahan, F.,Hammarstrom, M. L.,Melgar, S.,Nally, K. (2012) MiR-375 is a Key Regulator of Intestinal Homeostasis in Response to Inflammatory Stress DDW 2012; Gastroenterology Globe icon [Details]
(2012)DDW 2012; Gastroenterology
Darby, T.,Clarke, D.,Nally, K.,Shanahan, F.,Melgar, S. (2012) Deficiency in ATG16L1 Increases the Ability of the Adherent-Invasive Escherichia coli (HM605) to Replicate in and Reduce Barrier Integrity of Intestinal Epithelial Cells DDW 2012; Gastroenterology Globe icon [Details]
(2012)DDW 2012; Gastroenterology
Hall, L. J.,Murphy, C.,Quinlan, A.,Hurley, G.,Shanahan, F.,Nally, K.,Melgar, S. (2012) NK Cells Protect Mice During Acute Experimental Colitis by Regulating Neutrophil Function via NKG2A-dependent Mechanisms DDW 2012; Gastroenterology Globe icon [Details]
(2011)DDW 2011; Gastroenterology
Woznicki, J.,Shanahan, F.,Melgar, S.,Nally, K. (2011) IFN-gamma and TNF-alpha Synergise to Induce Expression of the Novel PRO-Apoptotic Gene BCL-G and Apoptosis in Intestinal Epithelial Cells and BCL-G Expression is Reduced in Inflammatory Bowel Disease (IBD) and Colon Cancer DDW 2011; Gastroenterology Globe icon [Details]
(2011)DDW 2011; Gastroenterology
Moloney, G.,Fanning, A.,O'Malley, D.,Scanlan, N.,Cryan, J. F.,Dinan, T. G.,Shanahan, F.,Quigley, E. M.,Melgar, S.,Nally, K. (2011) Stimulation of T-Cells in Irritable Bowel Syndrome (IBS) Mucosal Biopsy Tissue Releases Cytokines Which Selectively Activate Submucosal Neurons DDW 2011; Gastroenterology Globe icon [Details]
(2011)DDW 2011; Gastroenterology
Lapthorne, S.,MacSharry, J.,Scully, P.,Nally, K.,Shanahan, F. (2011) The Discriminatory Intelligence of M Cells - Beyond a Simple Translocation Portal DDW 2011; Gastroenterology Globe icon [Details]
(2011)DDW 2011; Gastroenterology
Murphy, C.,Hall, L. J.,Hurley, G.,Quinlan, A.,Shanahan, F.,Nally, K.,Melgar, S. (2011) The Immunomodulatory Drug FTY720 Prevents Clearance of Citrobacter rodentium Infection in Mice DDW 2011; Gastroenterology Globe icon [Details]
(2011)DDW 2011; Gastroenterology
Ambrose, M.,O'Keeffe, A.,Fanning, A.,Murphy, C.,Hurley, G.,Quinlan, A.,Mac Sharry, J.,Hammarstrom, M. L.,Hessel, E. M.,Lee, K.,Shanahan, F.,Melgar, S.,Nally, K. (2011) MiR-146a Negatively Regulates IL-17A Inflammatory Response and is Elevated in Intestinal Epithelial Cells From Inflammatory Bowel Disease (IBD) Patients DDW 2011; Gastroenterology Globe icon [Details]
(2009)DDW 2009; Gastroenterology
Moloney, G.,Corr, S.,Hall, L. J.,Murphy, C.,Quinlan, A.,Kruidenier, L.,Calver, A. R.,Mclean, P. G.,Lee, K.,Shanahan, F.,Nally, K.,Melgar, S. (2009) The Effect of the Farnesoid X Receptor (FXR) and It's Agonist-GSK488062B-On Experimental Models of Colitis and Cytokine Production from IBD Tissue DDW 2009; Gastroenterology Globe icon [Details]
(2009)DDW 2009; Gastroenterology
Hall, L. J.,Quinlan, A.,Shanahan, F.,Nally, K.,Melgar, S. (2009) Natural Killer Cell Responses in Both Acute and Chronic Phases of a Murine Model of Experimental Colitis DDW 2009; Gastroenterology Globe icon [Details]
(2008)DDW 2008; Gastroenterology
Docena, G. H.,Fanning, A.,Rovedatti, L.,Di Sabatino, A.,Leakey, N. A.,Knowles, C. H.,Lee, K.,Shanahan, F.,Nally, K.,McLean, P.,MacDonald, T. T.,Kruidenier, L. (2008) Activation and modulation of the MAP kinase pathway in IBD DDW 2008; Gastroenterology Globe icon [Details]
(2008)DDW 2008; Gastroenterology
Corr, S. C.,O'Hara, A.,O'Mahony, L.,Nally, K.,Shanahan, F.,Hill, C.,Gahan, C. G. (2008) Mechanism of epithelial CCL20 response to listeria DDW 2008; Gastroenterology Globe icon [Details]
(2008)BMC Gastroenterology
Murphy, C.,Moloney, G.,Casey, P.,Haynes, A. C.,Kruidenier, L.,Calver, A.,McLean, P.,Lee, K.,Hill, C.,O'Mahony, L.,Shanahan, F.,Nally, K. (2008) Modification of lymphocyte trafficking in an in vivo model of IBD following administration of a novel alpha 4 integrin antagonist BMC Gastroenterology Globe icon [Details]
(2006)DDW 2006; Gastroenterology
Nally, K.,O'Brien, D.,MacSharry, J.,Bairead, E.,O'Sullivan, G. C.,O'Connell, J.,Shanahan, F. (2006) IFN gamma and TNF alpha synergize to induce maximal NF-kappa B activation, NF-kappa B mediated trail expression and apoptosis of colonic epithelial cells DDW 2006; Gastroenterology Globe icon [Details]
(2004)DDW 2004; Gastroenterology
Nally, K.,O'Brien, D.,O'Connell, J.,Shanahan, F. (2004) Interferon gamma(IFN-gamma) selectively suppresses TNF-alpha-induced COX-1 and COX-2 expression in intestinal epithelial cells by inhibiting NF-kappa B function DDW 2004; Gastroenterology Globe icon [Details]
(2004)DDW 2004; Gastroenterology
Rosberg-Cody, E.,Ross, P.,Nally, K.,Anwar, M.,O'Mahony, L.,Ryan, A.,Hussey, S.,Murphy, B.,Fitzgerald, G.,Shanahan, F.,Stanton, C. (2004) Metabolic basis of host-flora interactions in the gut - Role of CLA DDW 2004; Gastroenterology Globe icon [Details]
(2001)DDW 2001; Gastroenterology
Nally, K.,Mullan, B.,O'Connell, J.,Morgan, J.,Collins, J. K.,O'Sullivan, G. C.,Shanahan, F. (2001) Pro inflammatory cytokines suppress p53 function in colonic epithelial cells - A link between inflammation and tumorigenesis DDW 2001; Gastroenterology Globe icon [Details]
(2001)DDW 2001; Gastroenterology
Nally, K.,Kelly, R.,Ryan, P.,O'Connell, J.,O'Sullivan, G. C.,Morgan, J.,Shanahan, F. (2001) The chemopreventative agent N-acetyl-L-cysteine (NAC) decreases epidermal growth factor receptor (EGFR) levels on colonic carcinoma cell lines DDW 2001; Gastroenterology Globe icon [Details]
(2001)DDW 2001; Gastroenterology
Nally, K.,O'Connell, J.,Morgan, J.,Collins, J. K.,O'Sullivan, G. C.,Shanahan, F. (2001) IGF-1 protects colonic epithelial cells from cytokine induced apoptosis by maintaining cellular phospho-tyrosine content and preventing cytochrome C release DDW 2001; Gastroenterology Globe icon [Details]
(2000)DDW 2000; Gastroenterology
Nally, K.,O'Connell, J.,Morgan, J.,O'Sullivan, G. C.,Collins, J. K.,Shannon, F. L. (2000) The Th1 cytokines IFN-gamma and TNF-alpha reactivate components of the p53 pathway in mutant p53 epithelial cells DDW 2000; Gastroenterology Globe icon [Details]
(2000)DDW 2000; Gastroenterology
Nally, K.,O'Connell, J.,Morgan, J.,O'Sullivan, G. C.,Collins, J. K.,Shanahan, F. L. (2000) Maximal activation of epithelial NFKB - An additional molecular mechanism underlying synergy between IFN-Gamma and TNF-Alpha DDW 2000; Gastroenterology Globe icon [Details]
(1999)DDW 1999; Gastroenterology
Nally, K.,O'Connell, J.,Morgan, J.,O'Sullivan, G. C.,Collins, J. K.,Shanahan, F. L. J. (1999) The commitment to die: Role of c-myc in lowering epithelial cell threshold for apoptosis by IFN-gamma and TNF-alpha DDW 1999; Gastroenterology Globe icon [Details]
(1998)DDW 1998; Gastroenterology
Nally, K.,Newton, F.,O'Connell, J.,Morgan, J.,O'Sullivan, G. C.,Collins, J. K.,Shanahan, F. (1998) Epithelial cytoprotection is part of the therapeutic effect of interleukin-10 in mucosal inflammation DDW 1998; Gastroenterology Globe icon [Details]
(1997)DDW 1997; Gastroenterology
Winter, D. C.,Nally, K.,OCallaghan, J.,Matthews, J. B.,Harvey, B. J.,OSullivan, G. C.,Shanahan, F. (1997) Cytoskeletal disruption by jasplakinolide inhibits colon cancer growth in vitro DDW 1997; Gastroenterology Globe icon [Details]

Book Chapters

YearPublication
(2002)'Rapid development of a quantitative-competitive (qc) RT-PCR assay using a composite primer approach'
O'Connell J., Houston A., Kelly R., O'Brien D., Ryan A., Bennett MW., Nally K.; (2002) 'Rapid development of a quantitative-competitive (qc) RT-PCR assay using a composite primer approach' In: Methods in Molecular Biology. New Jersey: Humana Press. [Details]

Teaching Interests

My main interest and objective in teaching is to try and make students be they undergraduate or postgraduate as excited and enthusiastic about continual learning as I am. Part of the motivation for learning has to come in some way from an innate curiosity about the natural world we live in, how it all works and how understanding that natural world can lead to new possibilities for knowledge and the application of knowledge to treating for example human diseases such as chronic inflammatory diseases and cancer. So, a main objective of my teaching is to ignite a little bit of that innate curiosity which lies within all of us and to assist students to use that curiosity as a source of motivation to learn about the biology that is relevant to their own lives, course or research project. It is important therefore to continually remind students about the relevance of the discipline been taught and how the discovery and application of existing and new knowledge might give us fresh insights into the biological world and ultimately have a positive impact on human health and disease.

Modules Taught

 Term (ID))TitleLinkSubject
2015Advanced Metabolism BC4016Advanced Metabolism
2015Advanced Metabolism BC3002Advanced Metabolism
2015Literature Project BC3012Literature Project
2015Research Project BC4012Research Project
2015Fundamentals of Medicine III GM1003Fundamentals of Medicine III