Biography
Dr. Abina Crean graduated with a degree in Pharmacy from Robert Gordon's University, Aberdeen, Scotland. She completed a PhD in Pharmaceutics in the School of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin. Dr. Crean was employed as a formulation scientist with Elan Pharmaceutical Technologies between 1997 and 2001 and as a Process Development Pharmacist at Servier (Ireland) Industries between 2002 and 2003.
She joined the School of Pharmacy in UCC in 2003 upon establishment, she has been actively involved in the development of its research facilities and curriculum. As PI, she established a pharmaceutical technology research group in UCC and supervised a range research projects in the areas of pharmaceutical manufacturing and formulation science. A key element of her research is active collaborative projects with a number of pharmaceutical companies both SME and large multi-nationals. She is a funded researcher in the SFI funded SSPC - Science Foundation Ireland (SFI) Pharmaceutical Research Centre.
She joined the School of Pharmacy in UCC in 2003 upon establishment, she has been actively involved in the development of its research facilities and curriculum. As PI, she established a pharmaceutical technology research group in UCC and supervised a range research projects in the areas of pharmaceutical manufacturing and formulation science. A key element of her research is active collaborative projects with a number of pharmaceutical companies both SME and large multi-nationals. She is a funded researcher in the SFI funded SSPC - Science Foundation Ireland (SFI) Pharmaceutical Research Centre.
Research Interests
My research interests are focused on the development of high quality, effective medicines through thorough investigation and understanding of the properties and associated behaviour of constituent materials (both API and excipients).
Examples of current research projects include
- Development of quality by design strategies to study the critical material attributes of pharmaceutical excipients
- Enabling continuous pharmaceutical solid oral dosage from manufacture through identification, control and monitoring of critical material attributes
- Formulation and characterisation of microneedle drug and vaccine delivery systems
- Development of silica-based drug formulations to enhance the oral bioavailability of therapeutic compounds challenged by poor-water solubility
- Biophysical characterisation, processing and formulation of peptide, protein and vaccine materials
- Manipulation of commercial dosage forms for administration to elderly patients
Publications
Peer Reviewed Journals
| Year | Publication | |
|---|---|---|
| (2024) | 'Stress factors affecting protein stability during the fabrication and storage of dissolvable microneedles' Koenitz, Laura and Crean, Abina and Vucen, Sonja (2024) 'Stress factors affecting protein stability during the fabrication and storage of dissolvable microneedles'. RPS Pharmacy and Pharmacology Reports, 3 (3) [DOI] [Details] | |
| (2024) | 'Ten years of the manufacturing classification system: a review of literature applications and an extension of the framework to continuous manufacture' Leane M;Pitt K;Reynolds G;Tantuccio A;Moreton C;Crean A;Kleinebudde P;Carlin B;Gamble J;Gamlen M;Stone E;Kuentz M;Gururajan B;Khimyak YZ;Van Snick B;Andersen S;Misic Z;Peter S;Sheehan S; (2024) 'Ten years of the manufacturing classification system: a review of literature applications and an extension of the framework to continuous manufacture'. Pharmaceutical Development And Technology, 29 (5) [DOI] [Details] | |
| (2024) | 'Colyophilized Sugar-Polymer Dispersions for Enhanced Processing and Storage Stability' Giannachi C;Allen E;Egan G;Vucen S;Crean A; (2024) 'Colyophilized Sugar-Polymer Dispersions for Enhanced Processing and Storage Stability'. Molecular Pharmaceutics, 21 (6) [DOI] [Details] | |
| (2024) | 'Nebulised delivery of RNA formulations to the lungs: From aerosol to cytosol' Neary MT;Mulder LM;Kowalski PS;MacLoughlin R;Crean AM;Ryan KB; (2024) 'Nebulised delivery of RNA formulations to the lungs: From aerosol to cytosol'. Journal Of Controlled Release, 366 [DOI] [Details] | |
| (2024) | 'Elucidating the Degradation Pathways of Human Insulin in the Solid State' Fagan, Andrew,Bateman, Lorraine M.,O’Shea, Joseph P.,Crean, Abina M. (2024) 'Elucidating the Degradation Pathways of Human Insulin in the Solid State'. Journal of Analysis and Testing, [Details] | |
| (2023) | 'In-Vial Detection of Protein Denaturation Using Intrinsic Fluorescence Anisotropy' Chullipalliyalil K;Elkassas K;McAuliffe MAP;Vucen S;Crean A; (2023) 'In-Vial Detection of Protein Denaturation Using Intrinsic Fluorescence Anisotropy'. Analytical Chemistry, [DOI] [Details] | |
| (2023) | 'The impact of drug palatability on prescribing and dispensing of antibiotic formulations for paediatric patients: a cross-sectional survey of general practitioners and pharmacists' Ayat Elgammal, Joseph Ryan, Colin Bradley, Abina Crean, Margaret Bermingham (2023) 'The impact of drug palatability on prescribing and dispensing of antibiotic formulations for paediatric patients: a cross-sectional survey of general practitioners and pharmacists'. Family Practice, [DOI] [Details] | |
| (2023) | 'Study of the feeding performance of mesoporous silica in a loss-in-weight feeder' Kerins B.M.;O'Mahony M.;Crean A.M. (2023) 'Study of the feeding performance of mesoporous silica in a loss-in-weight feeder'. Powder Technology, 424 [DOI] [Details] | |
| (2022) | 'Rational and practical considerations to guide a Target Product Profile for patient-centric drug product development with measurable patient outcomes - A proposed roadmap' Stegemann S;Sheehan L;Rossi A;Barrett A;Paudel A;Crean A;Ruiz F;Bresciani M;Liu F;Shariff Z;Shine M;Schmelzer C;Pense-Lheritier AM; (2022) 'Rational and practical considerations to guide a Target Product Profile for patient-centric drug product development with measurable patient outcomes - A proposed roadmap'. European Journal Of Pharmaceutics And Biopharmaceutics, [DOI] [Details] | |
| (2022) | 'Modelling the Compaction Step of a Platform Direct Compression Process' Peddapatla, Raghu V. G. and Slevin, Conor and Sheridan, Gerard and Beirne, Caoimhe and Swaminathan, Shrikant and Browning, Ivan and O’Reilly, Clare and Worku, Zelalem A. and Egan, David and Sheehan, Stephen and Crean, Abina M. (2022) 'Modelling the Compaction Step of a Platform Direct Compression Process'. Pharmaceutics, 14 (4) [DOI] [Details] | |
| (2021) | 'Process Model Approach to Predict Tablet Weight Variability for Direct Compression Formulations at Pilot and Production Scale' Peddapatla, Raghu V. G. and Sheridan, Gerard and Slevin, Conor and Swaminathan, Shrikant and Browning, Ivan and O’Reilly, Clare and Worku, Zelalem A. and Egan, David and Sheehan, Stephen and Crean, Abina M. (2021) 'Process Model Approach to Predict Tablet Weight Variability for Direct Compression Formulations at Pilot and Production Scale'. Pharmaceutics, 13 (7) [DOI] [Details] | |
| (2021) | 'Investigating microcrystalline cellulose crystallinity using Raman spectroscopy' Queiroz A.L.P.;Kerins B.M.;Yadav J.;Farag F.;Faisal W.;Crowley M.E.;Lawrence S.E.;Moynihan H.A.;Healy A.M.;Vucen S.;Crean A.M. (2021) 'Investigating microcrystalline cellulose crystallinity using Raman spectroscopy'. Cellulose, 28 (14):8971-8985 [DOI] [Full Text] [Details] | |
| (2021) | 'Sounding out stability of enteric coated dosage forms using Broadband Acoustic Resonance Dissolution Spectroscopy (BARDS)' O'Mahoney N;Alfarsi A;O'Sullivan H;McSweeney S;Crean A;Fitzpatrick D; (2021) 'Sounding out stability of enteric coated dosage forms using Broadband Acoustic Resonance Dissolution Spectroscopy (BARDS)'. International Journal of Pharmaceutics, 602 [DOI] [Details] | |
| (2021) | 'Fluorescence spectroscopy for the determination of reconstitution time of an in-vial lyophilised product' ElKassas K;Chullipalliyalil K;McAuliffe M;Vucen S;Crean A; (2021) 'Fluorescence spectroscopy for the determination of reconstitution time of an in-vial lyophilised product'. International Journal of Pharmaceutics, 597 [DOI] [Details] | |
| (2021) | 'Osteointegration, antimicrobial and antibiofilm activity of orthopaedic titanium surfaces coated with silver and strontium-doped hydroxyapatite using a novel blasting process' O' Sullivan C;O' Neill L;O' Leary ND;O' Gara JP;Crean AM;Ryan KB; (2021) 'Osteointegration, antimicrobial and antibiofilm activity of orthopaedic titanium surfaces coated with silver and strontium-doped hydroxyapatite using a novel blasting process'. Drug Delivery And Translational Research, [DOI] [Details] | |
| (2021) | 'Determination of co-crystal phase purity by mid infrared spectroscopy and multiple curve resolution' Queiroz ALP;Rodrigues M;Zeglinski J;Crean AM;Sarraguça MC;Vucen S; (2021) 'Determination of co-crystal phase purity by mid infrared spectroscopy and multiple curve resolution'. International Journal of Pharmaceutics, 595 [DOI] [Details] | |
| (2020) | 'Engineered food supplement excipients from bitter cassava for minimisation of cassava processing waste in environment' K.S.Tumwesigyea, E.O'Brien, J.C.Oliveira, A.Crean, M.J. Sousa Gallagher (2020) 'Engineered food supplement excipients from bitter cassava for minimisation of cassava processing waste in environment'. Future Foods, 1-2 [DOI] [Details] | |
| (2020) | 'Long-term stability of insulin glulisine loaded nanoparticles formulated using an amphiphilic cyclodextrin and designed for intestinal delivery' Presas E;Sultan E;Gervasi V;Crean AM;Werner U;Bazile D;O'Driscoll CM; (2020) 'Long-term stability of insulin glulisine loaded nanoparticles formulated using an amphiphilic cyclodextrin and designed for intestinal delivery'. Drug Development and Industrial Pharmacy, [DOI] [Details] | |
| (2020) | 'Application of percolation threshold to disintegration and dissolution of ibuprofen tablets with different microcrystalline cellulose grades' Queiroz A.L.P.;Wood B.;Faisal W.;Farag F.;Garvie-Cook H.;Glennon B.;Vucen S.;Crean A.M. (2020) 'Application of percolation threshold to disintegration and dissolution of ibuprofen tablets with different microcrystalline cellulose grades'. International Journal of Pharmaceutics, 589 [DOI] [Full Text] [Details] | |
| (2020) | 'Comparison of Drug Release and Adsorption under Supersaturating Conditions for Ordered Mesoporous Silica with Indomethacin or Indomethacin Methyl Ester' McCarthy C.A.;Zemlyanov D.Y.;Crean A.M.;Taylor L.S. (2020) 'Comparison of Drug Release and Adsorption under Supersaturating Conditions for Ordered Mesoporous Silica with Indomethacin or Indomethacin Methyl Ester'. Molecular Pharmaceutics, 17 (8):3062-3074 [DOI] [Details] | |
| (2019) | 'Understanding the knowledge, attitudes and beliefs of community-dwelling older adults and their carers about the modification of oral medicines: A qualitative interview study to inform healthcare professional practice' Mc Gillicuddy A.;Kelly M.;Crean A.;Sahm L. (2019) 'Understanding the knowledge, attitudes and beliefs of community-dwelling older adults and their carers about the modification of oral medicines: A qualitative interview study to inform healthcare professional practice'. Research In Social & Administrative Pharmacy : Rsap, [DOI] [Details] | |
| (2019) | 'The application of percolation threshold theory to predict compaction behaviour of pharmaceutical powder blends' ALP Queiroz, W Faisal, K Devine, H Garvie-Cook, S Vucen, AM Crean (2019) 'The application of percolation threshold theory to predict compaction behaviour of pharmaceutical powder blends'. Powder Technology, 354 :188-198 [DOI] [Details] | |
| (2019) | 'Application of a mixture DOE for the prediction of formulation critical temperatures during lyophilisation process optimisation' Gervasi V;Cullen S;McCoy T;Crean A;Vucen S; (2019) 'Application of a mixture DOE for the prediction of formulation critical temperatures during lyophilisation process optimisation'. International Journal of Pharmaceutics, [DOI] [Details] | |
| (2018) | 'Experimental Study on the Influence of Excipients on the Heterogeneous Crystallization and Dissolution Properties of an Active Pharmaceutical Ingredient' Vivek Verma, Raghu V. G. Peddapatla, Clare M. Crowley, Abina M. Crean, Peter Davern, Sarah Hudson, Benjamin K. Hodnett (2018) 'Experimental Study on the Influence of Excipients on the Heterogeneous Crystallization and Dissolution Properties of an Active Pharmaceutical Ingredient'. Crystal Growth & Design, 18 (1):338-350 [DOI] [Details] | |
| (2018) | 'Continuous powder feeding for pharmaceutical solid dosage form manufacture: a short review' Blackshields, Caroline A.; Crean, Abina M. (2018) 'Continuous powder feeding for pharmaceutical solid dosage form manufacture: a short review'. Pharmaceutical Development And Technology, 23 (6):554-560 [DOI] [Full Text] [Details] | |
| (2018) | 'Role of drug adsorption onto the silica surface in drug release from mesoporous silica systems' McCarthy, Carol A.; Ahern, Robert J.; Devine, Ken J.; Crean, Abina M. (2018) 'Role of drug adsorption onto the silica surface in drug release from mesoporous silica systems'. Molecular Pharmaceutics, 15 (1):141-149 [DOI] [Full Text] [Details] | |
| (2018) | 'Broadband Acoustic Resonance Dissolution Spectroscopy (BARDS) - A novel approach to investigate the wettability of pharmaceutical powder blends' Peddapatla, Raghhu V.G.; Ahmed M. Rizwan ;Blackshields Caroline A.;Sousa-Gallagher M.J.; McSweeney Sean; Krüse J.; Crean Abina M.; Fitzpatrick Dara (2018) 'Broadband Acoustic Resonance Dissolution Spectroscopy (BARDS) - A novel approach to investigate the wettability of pharmaceutical powder blends'. Molecular Pharmaceutics, 15 (1):31-39 [DOI] [Full Text] [Details] | |
| (2018) | 'Manufacturing Classification System in the real world: factors influencing manufacturing process choices for filed commercial oral solid dosage formulations, case studies from industry and considerations for continuous processing' Michael Leane, Kendal Pitt, Gavin K. Reynolds, Neil Dawson, Iris Ziegler, Aniko Szepes, Abina M. Crean & Rafaela Dall Agnol (2018) 'Manufacturing Classification System in the real world: factors influencing manufacturing process choices for filed commercial oral solid dosage formulations, case studies from industry and considerations for continuous processing'. Pharmaceutical Development And Technology, [DOI] [Details] | |
| (2018) | 'Parenteral protein formulations: an overview of approved products within the European Union' Gervasi, V.; Dall Agnol, R.; Cullen, S.; McCoy, T.; Vucen, Sonja; Crean, Abina (2018) 'Parenteral protein formulations: an overview of approved products within the European Union'. European Journal Of Pharmaceutics And Biopharmaceutics, 131 :8-24 [DOI] [Full Text] [Details] | |
| (2017) | 'The knowledge, attitudes and beliefs of patients and their healthcare professionals around oral dosage form modification: A systematic review of the qualitative literature' Mc Gillicuddy A;Kelly M;Crean AM;Sahm LJ; (2017) 'The knowledge, attitudes and beliefs of patients and their healthcare professionals around oral dosage form modification: A systematic review of the qualitative literature'. Research In Social & Administrative Pharmacy : Rsap, 13 (4) [DOI] [Details] | |
| (2017) | 'Oral medicine modification for older adults: a qualitative study of nurses' Mc Gillicuddy A;Crean AM;Kelly M;Sahm L; (2017) 'Oral medicine modification for older adults: a qualitative study of nurses'. Bmj Open, 7 (12) [DOI] [Details] | |
| (2017) | 'Near-infrared monitoring of roller compacted ribbon density: Investigating sources of variation contributing to noisy spectral data' Crowley, Mary Ellen; Hegarty, Avril; McAuliffe, Michael A.P.; O'Mahony, Graham E.; Kiernan, Luke; Hayes, Kevin; Crean, Abina M. (2017) 'Near-infrared monitoring of roller compacted ribbon density: Investigating sources of variation contributing to noisy spectral data'. European Journal of Pharmaceutical Sciences, 102 :103-114 [DOI] [Full Text] [Details] | |
| (2017) | 'In vitro dissolution models for the prediction of in vivo performance of an oral mesoporous silica formulation' McCarthy, Carol A.; Faisal, Waleed; O'Shea, Joseph P.; Murphy, Colm; Aherne, Robert J.; Ryan, Katie B.; Griffin, Brendan T.; Crean, Abina M. (2017) 'In vitro dissolution models for the prediction of in vivo performance of an oral mesoporous silica formulation'. Journal Of Controlled Release, 250 :86-95 [DOI] [Full Text] [Details] | |
| (2016) | 'Assessment of measurement characteristics for rehydration of milk protein based powders' Ji, JF;Fitzpatrick, J;Cronin, K;Crean, A;Miao, S (2016) 'Assessment of measurement characteristics for rehydration of milk protein based powders'. Food Hydrocolloids, 54 :151-161 [DOI] [Details] | |
| (2016) | 'Mesoporous silica formulation strategies for drug dissolution enhancement: A review' Mccarthy C.;Ahern R.;Dontireddy R.;Ryan K.;Crean A. (2016) 'Mesoporous silica formulation strategies for drug dissolution enhancement: A review'. Expert Opinion On Drug Delivery, 13 (1):93-108 [DOI] [Details] | |
| (2016) | 'Induction of broad immunity by thermostabilised vaccines incorporated in dissolvable microneedles using novel fabrication methods' Vrdoljak A, Allen EA1, Ferrara F, Temperton NJ, Crean AM, Moore AC (2016) 'Induction of broad immunity by thermostabilised vaccines incorporated in dissolvable microneedles using novel fabrication methods'. Journal of controlled release : official journal of the Controlled Release Society, [DOI] [Details] | |
| (2016) | 'Modification of oral dosage forms for the older adult: An Irish prevalence study' Mc Gillicuddy, A;Kelly, M;Sweeney, C;Carmichael, A;Crean, AM;Sahm, LJ (2016) 'Modification of oral dosage forms for the older adult: An Irish prevalence study'. International Journal of Pharmaceutics, 510 :386-393 [DOI] [Details] | |
| (2016) | 'Integrated process standardisation as zero-based approach to bitter cassava waste elimination and widely-applicable industrial biomaterial derivatives' Tumwesigye, KS;Peddapatla, RVG;Crean, A;Oliveira, JC;Sousa-Gallagher, MJ (2016) 'Integrated process standardisation as zero-based approach to bitter cassava waste elimination and widely-applicable industrial biomaterial derivatives'. Chemical Engineering And Processing, 108 :139-150 [DOI] [Details] | |
| (2016) | 'Dissolvable microneedle fabrication using piezoelectric dispensing technology' Allen, E. A.,O'Mahony, C.,Cronin, M.,O'Mahony, T.,Moore, A. C.,Crean, A. M. (2016) 'Dissolvable microneedle fabrication using piezoelectric dispensing technology'. International Journal of Pharmaceutics, 500 (1-2):1-10 [DOI] [Details] | |
| (2015) | 'Older adults with difficulty swallowing oral medicines: a systematic review of the literature' Mc Gillicuddy A, Crean AM;Sahm LJ (2015) 'Older adults with difficulty swallowing oral medicines: a systematic review of the literature'. European Journal of Clinical Pharmacology, [DOI] [Details] | |
| (2015) | 'Quality by design in an evolving manufacturing sector' Crowley M.E., Crean A. M, (2015) 'Quality by design in an evolving manufacturing sector'. European Journal of Parenteral and Pharmaceutical Sciences, 20 (2):63-69 [Details] | |
| (2015) | 'Quality by design in an evolving manufacturing sector' Crowley M.;Crean A. (2015) 'Quality by design in an evolving manufacturing sector'. European Journal of Parenteral and Pharmaceutical Sciences, 20 (2):63-69 [Details] | |
| (2015) | 'A proposal for a drug product Manufacturing Classification System (MCS) for oral solid dosage forms' Leane, M;Pitt, K;Reynolds, G (2015) 'A proposal for a drug product Manufacturing Classification System (MCS) for oral solid dosage forms'. Pharmaceutical Development And Technology, 20 :12-21 [DOI] [Details] | |
| (2014) | 'The Use of PAT and Off-line Methods for Monitoring of Roller Compacted Ribbon and Granule Properties with a View to Continuous Processing' M. A. P. McAuliffe, G. E. O’Mahony, C. A. Blackshields, J. A. Collins, D. P. Egan, L. Kiernan, E. O’Neill, S. Lenihan, G. M. Walker, A. M. Crean (2014) 'The Use of PAT and Off-line Methods for Monitoring of Roller Compacted Ribbon and Granule Properties with a View to Continuous Processing'. Organic Process Research & Development, [DOI] [Details] | |
| (2014) | 'Production of dissolvable microneedles using an atomised spray process: effect of microneedle composition on skin penetration' McGrath, M. G.,Vucen, S.,Vrdoljak, A.,Kelly, A.,O'Mahony, C.,Crean, A. M.,Moore, A. (2014) 'Production of dissolvable microneedles using an atomised spray process: effect of microneedle composition on skin penetration'. Eur J Pharm Biopharm, 86 (2):200-11 [DOI] [Details] | |
| (2014) | 'Enhancement of the in vitro penetration of quercetin through pig skin by combined microneedles and lipid microparticles' Paleco R., Vučen S.R., Crean A.M., Moore A.C., Scalia S (2014) 'Enhancement of the in vitro penetration of quercetin through pig skin by combined microneedles and lipid microparticles'. International Journal of Pharmaceutics, [DOI] [Details] | |
| (2013) | 'Comparison of fenofibrate-mesoporous silica drug-loading processes for enhanced drug delivery' Ahern, RJ;Hanrahan, JP;Tobin, JM;Ryan, KB;Crean, AM (2013) 'Comparison of fenofibrate-mesoporous silica drug-loading processes for enhanced drug delivery'. European Journal of Pharmaceutical Sciences, 50 :400-409 [DOI] [Details] | |
| (2013) | 'Improved percutaneous delivery of ketoprofen using combined application of nanocarriers and silicon microneedles' Vucen, SR;Vuleta, G;Crean, AM;Moore, AC;Ignjatovic, N;Uskokovic, D (2013) 'Improved percutaneous delivery of ketoprofen using combined application of nanocarriers and silicon microneedles'. Journal of Pharmacy and Pharmacology, 65 :1451-1462 [DOI] [Details] | |
| (2012) | 'An Analysis of the Influence of Multiple Processing Factors on the Characteristics of Bioactive-Loaded Beads Prepared by Extrusion-Spheronisation' Kuang, SS,Oliveira, JC,Crean, AM (2012) 'An Analysis of the Influence of Multiple Processing Factors on the Characteristics of Bioactive-Loaded Beads Prepared by Extrusion-Spheronisation'. Food and Bioprocess Technology, 5 :55-64 [DOI] [Details] | |
| (2012) | 'The influence of supercritical carbon dioxide (SC-CO2) processing conditions on drug loading and physicochemical properties' Ahern, RJ;Crean, AM;Ryan, KB (2012) 'The influence of supercritical carbon dioxide (SC-CO2) processing conditions on drug loading and physicochemical properties'. International Journal of Pharmaceutics, 439 :92-99 [DOI] [Details] | |
| (2012) | 'Coated microneedle arrays for transcutaneous delivery of live virus vaccines' Vrdoljak, A,McGrath, MG,Carey, JB,Draper, SJ,Hill, AVS,O'Mahony, C,Crean, AM,Moore, AC (2012) 'Coated microneedle arrays for transcutaneous delivery of live virus vaccines'. Journal Of Controlled Release, 159 (1):34-42 [DOI] [Details] | |
| (2011) | 'Determination of parameters for successful spray coating of silicon microneedle arrays' McGrath MG, Vrdoljak A, O'Mahony C, Oliveira JC, Moore AC, Crean AM; (2011) 'Determination of parameters for successful spray coating of silicon microneedle arrays'. International Journal of Pharmaceutics, 415 :140-149 [DOI] [Full Text] [Details] | |
| (2011) | 'Microneedle array design determines the induction of protective memory CD8+ T cell responses induced by a recombinant live malaria vaccine in mice' Carey, J. B.,Pearson, F. E.,Vrdoljak, A.,McGrath, M. G.,Crean, A. M.,Walsh, P. T.,Doody, T.,O'Mahony, C.,Hill, A. V.,Moore, A. C. (2011) 'Microneedle array design determines the induction of protective memory CD8+ T cell responses induced by a recombinant live malaria vaccine in mice'. Plos One, 6 (7) [DOI] [Details] | |
| (2011) | 'A comparative study of spray-dried and freeze-dried hydrocortisone/polyvinyl pyrrolidone solid dispersions' Rakesh Dontireddy, Abina M Crean; (2011) 'A comparative study of spray-dried and freeze-dried hydrocortisone/polyvinyl pyrrolidone solid dispersions'. Drug Development and Industrial Pharmacy, 37 (10):1141-1149 [DOI] [Details] | |
| (2011) | 'Evaluation of the influence of granulation processing parameters on the granule properties and dissolution characteristics of a modified release drug' Ring, DT;Oliveira, JCO;Crean, A (2011) 'Evaluation of the influence of granulation processing parameters on the granule properties and dissolution characteristics of a modified release drug'. Advanced Powder Technology, 22 :245-252 [DOI] [Details] | |
| (2011) | 'A Modified Surface on Titanium Deposited by a Blasting Process' C. O'Sullivan, P. O'Hare, G. Byrne, L. O'Neill, K. B. Ryan and A. M. Crean (2011) 'A Modified Surface on Titanium Deposited by a Blasting Process'. Coatings, 1 (1):53-71 [Details] | |
| (2010) | 'Development of stabilised vaccines with needle-free devices for targeted skin immunisation' Crean A.;Moore A.;O'Mahony C. (2010) 'Development of stabilised vaccines with needle-free devices for targeted skin immunisation'. European Pharmaceutical Review, (6):56-60 [Details] | |
| (2010) | 'Microencapsulation as a tool for incorporating bioactive ingredients into food' Kuang S.;Oliveira J.;Crean A. (2010) 'Microencapsulation as a tool for incorporating bioactive ingredients into food'. Critical Reviews In Food Science and Nutrition, 50 (10):951-968 [DOI] [Details] | |
| (2010) | 'Deposition of substituted apatites with anticolonizing properties onto titanium surfaces using a novel blasting process' O'Sullivan, C. and O'Hare, P. and O'Leary, N. D. and Crean, A. M. and Ryan, K. and Dobson, A. D. W. and O'Neill, L.; (2010) 'Deposition of substituted apatites with anticolonizing properties onto titanium surfaces using a novel blasting process'. Journal of Biomedical Materials Research, 95B (1):141-149 [DOI] [Details] | |
| (2010) | 'A Methodology for Knowledge Management in Biopharmaceutical Production' Coakley, Jennifer; Hogan, Nicola; McGuire, Linda; Griffin, Brendan; Casey, Colman; Campbell, Cliff; Crean, Abina; (2010) 'A Methodology for Knowledge Management in Biopharmaceutical Production'. Pharmaceutical Engineering, 30 (3):30-40 [Details] | |
| (2002) | 'Comparative physicochemical properties of hydrocortisone-PVP composites prepared using supercritical carbon dioxide by the GAS anti-solvent recrystallization process, by coprecipitation and by spray drying' Corrigan, O. I, Crean. A. M; (2002) 'Comparative physicochemical properties of hydrocortisone-PVP composites prepared using supercritical carbon dioxide by the GAS anti-solvent recrystallization process, by coprecipitation and by spray drying'. International Journal of Pharmaceutics, 245 (1-2):75-82 [Details] |
Book Chapters
| Year | Publication | |
|---|---|---|
| (2022) | 'Continuous Powder Feeding: Equipment Design and Material Considerations' Brian M. Kerins, Abina M. Crean (2022) 'Continuous Powder Feeding: Equipment Design and Material Considerations' In: Antonios Fytopoulos, Rohit Ramachandran, Panos M. Pardalos (eds). Optimization of Pharmaceutical Processes. Switzerland: Springer Nature. [DOI] [Full Text] [Details] | |
| (2021) | 'Inorganic Biomaterials to Support the Formation and Repair of Bone Tissue' Caroline O ' Sullivan, Grainne Kennedy, Liam O'Neill, Katie B Ryan (2021) 'Inorganic Biomaterials to Support the Formation and Repair of Bone Tissue' In: Gareth R Williams (eds). Biomedical Applications of Inorganic Materials. UK: Royal Society of Chemistry. [DOI] [Details] |
Books
| Year | Publication | |
|---|---|---|
| (2009) | The Physicochemical Basis of Pharmaceuticals. Humphrey Moynihan and Abina Crean; (2009) The Physicochemical Basis of Pharmaceuticals. Oxford: Oxford University Press. [Details] |
Conference Publications
| Year | Publication | |
|---|---|---|
| (2022) | 13th APS Pharm Sci Downey, J. D. & Crean, A. & Ryan, K. B., (2022) Investigating Buffer Effects on Lysozyme Adsorption to Borosilicate Glass 13th APS Pharm Sci Belfast, , pp.S1-S2 [DOI] [Details] | |
| (2022) | Academy of Pharmaceutical Sciences Conference Al-Dagamin, T. & O'Shea, J. P. & Crean, A. (2022) The impact of drug-loading factors on the solid-state form of ritonavir-mesoporous silica systems . In: Hannah Batchelor eds. Academy of Pharmaceutical Sciences Conference Belfast, [DOI] [Details] | |
| (2022) | 13th APS PharmSci International Conference Downey, J. D. & Crean, A. & Ryan, K. B., (2022) Investigating Buffer Effects on Lysozyme Adsorption to Borosilicate Glass 13th APS PharmSci International Conference Belfast, , pp.S1-S2 [DOI] [Details] | |
| (2022) | Prescribing and Research in Medicines Management (PRIMM) Elgammal, A.1,2, Ryan, J.3, Bradley, C., Crean, A., and Bermingham, M. (2022) How patient acceptability influences prescribing and dispensing of oral liquid antibiotics to children: A survey of community pharmacists Prescribing and Research in Medicines Management (PRIMM) [Details] |
Articles
| Year | Publication | |
|---|---|---|
| (2017) | The chemistry of Christmas (and the science of a hangover). Carol McCarthy, Abina Crean, Sarah Hayes (2017) The chemistry of Christmas (and the science of a hangover). RTE Brainstrom: Articles [Details] |
Professional Activities
Education
| Year | Institution | Qualification | Subject | |
|---|---|---|---|---|
| 1992 | Robert Gordon's University | BSc Pharm | Pharmacy | |
| 2015 | University College Cork | Postgrad Cert. in Teaching & Learning in HE | Teaching and Learning | |
| 1997 | Trinity College Dublin | PHD | Pharmaceutics |
Teaching Activities
Recent Postgraduates
| Graduation Year | Student Name | Institution | Degree Type | Thesis Title | |
|---|---|---|---|---|---|
| 2021 | Raghu Peddapatla | University College Cork | PHD | A STUDY OF MAGNESIUM STEARATE BEHAVIOUR IN PHARMACEUTICAL BLENDS AND TABLETS | |
| 2021 | Ana Luiza Pinto Queiroz | University College Cork | PHD | Application of pharmaceutical quality approaches and the development of process analytical technologies to improve pharmaceutical product and process understanding | |
| 2020 | Valeria Gervasi | University College Cork | Lyophilisation of High Concentration Protein Formulations | ||
| 2020 | Neil Day | University College Cork | MSc | The Impact of Variation in Freezing and Thawing Process Parameters on the Critical Quality Attributes of a Monoclonal Antibody | |
| 2019 | Carol McCarthy | University College Cork | PHD | Drug Dissolution from Mesoporous Silica Systems | |
| 2018 | Aoife McGillicuddy | University College Cork | PHD | Oral dosage form modifications for older adults: a mixed methods investigation | |
| 2018 | Mary Ellen Crowley | University College Cork | PhD | A STUDY OF MICROCRYSTALLINE CELLULOSE VARIABILITY AND HOW THIS IMPACTS COMPACTION PERFORMANCE | |
| 2016 | Evin Allen | University College Cork | PHD | Development of a Dissolvable Microneedle Influenza Vaccine Patch | |
| 2014 | Aisling Sheehan | University College Cork | M.Sc. | An investigation into influenza vaccine stability in a dissolvable microneedle formulation | |
| 2013 | Robert Ahern | University College Cork | PHD | Application of mesoporous silica for the oral delivery of poorly water-soluble drugs | |
| 2013 | Sean Cullen | University College Cork | M.Sc. | The impact of excipient state on the structure and stability of lyophilized biopharmaceuticals | |
| 2012 | Fatma Farag | PHD | An investigation of the chemical and physical stability of salmon calcitonin formulations | ||
| 2012 | Caroline O’Sullivan | University College Cork | PHD | Novel coatings for hard tissue implants | |
| 2012 | Denis Ring | University College Cork | PHD | Analysis and modelling of the influence of high shear wet granulation process parameters on critical quality attributes of an active pharmaceutical ingredient using robust design of experiments | |
| 2011 | Marie McGrath | University College Cork | PHD | Design and characterisation of Microneedles for Percutaneous Vaccine Delivery | |
| 2010 | Rakesh Dontireddy | University College Cork | PHD | Investigation of dissolution properties of amorphous drug and drug-carrier systems | |
| 2008 | Caroline Blackshields | University College Cork | PHD | Development of hydrogel based drug delivery systems of local anaesthetics |
Contact details
- Abina Crean
Professor of Pharmaceutics - a.crean@ucc.ie
- School of Pharmacy
University College Cork
Cork
Ireland - +353-21-490-1667
- +353-21-490-1656