Caitriona O'Driscoll

Professor of Pharmaceutics
School of Pharmacy
University College Cork
Cavanagh Pharmacy Building
Cork
Ireland

T: +353 21 490 1396
F: +353 21 490 1656
E: caitriona.odriscoll@ucc.ie
Professor
School of Pharmacy
University College Cork
Cork
Ireland

T: +353-21-490-3000
F: +353 21 490 1396
E: caitriona.odriscoll@ucc.ie
W: http://www.ucc.ie/acad/pharmschool/

Caitriona O'Driscoll is Professor and Chair of Pharmaceutics in the School of Pharmacy, University College Cork, Ireland.

Total Career Publications: 93

Publications 2008-14: 45

Total Citations: 2432

h-Index: 29

Total Career Research Income: Euro 4,635,099

Research Income (2008-2014): Euro 3,547,335

PhDs Graduated (Career): 20

PhDs Graduated (2008-2014): 6

She received a B.Sc. in Pharmacy from University College Dublin in 1976 and a PhD in 1983 from the University of Dublin, Trinity College. In 1977 she joined the faculty of the School of Pharmacy in Trinity College and held the posts of lecturer (1977-1994) and senior lecturer (1995-2003) in Pharmaceutics during which time she undertook a sabbatical in the Department of Pharmaceutical Chemistry at the University of Kansas. In 2003 she was appointed as Professor of Pharmaceutics at UCC and was, at the same time, appointed as the first Head of the School of Pharmacy at UCC, she served as Head from 2003-09 and 2010-13.

During her tenure as Professor of Pharmaceutics she has established an energetic, productive and expanding drug delivery research team. The expertise established spans from pre-formulation through to production and manufacture of prototype delivery systems suitable for clinical trial. The group has obtained funding from exchequer and non-exchequer sources and offers a range of PhD positions. Strong links to the Pharmaceutical Industry underpin many of the research projects. The establishment within UCC of the drug delivery group and the development of interactions with Pharmaceutical Chemistry and Process & Chemical Engineering at UCC gives the University a unique strength which facilitates drug development research from drug design and synthesis all the way through formulation and production to clinical trial.


Professor O'Driscoll has published peer-reviewed research articles in key pharmaceutical journals, including Journal of Controlled Release, Molecular Pharmaceutics, and Pharmaceutical Research. She has been invited to give lectures at various international conferences and institutions worldwide and is a member of the Editorial Advisory Board for several journals including European Journal of Pharmaceutical Sciences, Journal of Pharmaceutical Sciences, Journal of Pharmacy and Pharmacology, Journal of Drug Delivery, Science and Technology and Pharmaceutical Nanotechnology.

Professor O'Driscoll is an external examiner for University of Bath, Masters in Pharmacy and for the Pharmaceutical Society of Ireland, Professional Registration examination. She has acted as PhD thesis examiner in University of Nottingham, University of London, King's College London, University of Bath, University of Strathclyde, Cardiff University, Queen's University Belfast, Monash University Melbourne and Trinity College Dublin. She is serving as a member of the Irish Medicine Board (2011-2014) and the Pharmaceutical Society of Ireland (2011-2014) and is a member of the College of Medicine and Health Executive UCC and the School of Pharmacy Executive. Professor O'Driscoll was awarded the 'Person of the Year award' for outstanding contribution to science by the Parenteral Drug Association (Ireland Chapter) in 2013 and in 2007/2008 was honoured with the 'Award for Professional Excellence' and 'Award for Pharmacist of the Year' by Helix Health.
Professor O'Driscoll is a:

Board member of the Health Products Regulatory Authority (HPRA) (2011-15)

Council Member of the Pharmaceutical Society of Ireland (PSI) (2011-15)

Board Member of Cork Cancer Research Centre (CCRC) (2014-17)

Co-founder and Co-Chair of Regulatory Science Ireland (RSI) (2014-17)


Research Interests

Professor O’Driscoll’s research strategy is translational in nature and product driven. The theme of the research is drug delivery with an emphasis on `problem’ or difficult drugs e.g. poorly water soluble compounds, and, products of the pharmaceutical biotechnology industry including peptide/protein type drugs, plasma DNA and siRNA. These candidate drugs are chosen for strategic reasons. Greater than 40% of new chemical entities currently synthesised as potential drugs are poorly water soluble and consequently are difficult to formulate for efficient delivery. In recent years significant growth has occurred in the pharmaceutical biotechnology industry in Ireland and internationally. Biopharmaceuticals, including peptide/proteins, genes and siRNA, are now approaching 50% of all new drugs in development. It is well accepted that the major barrier to marketing these product as novel therapeutics is the design of efficient delivery systems. The focus has been to develop nano-sized delivery constructs which are robust enough to survive processing, are stable on storage and achieve cell /site specific delivery in vivo. Such targeted systems aim to increase therapeutic efficacy and reduce side effects or off target effects. In general the work includes a focus on oral drug delivery, while this is often the most challenging route of administration; it is the most acceptable route for the patient and consequently the most commercially viable. 

 

 

 

 

 

 



Research Grants

 ProjectFunding
Body
Start DateEnd DateAward
Formulation development and deposition of novel antibacterial coatings using atomic laser deposition to prevent infections associated with orthopaedic trauma implants.Science Foundation of Ireland01-JAN-1330-JUN-14€103,259.00
Development of Taste masking Platform TechnologiesIndustry01-JAN-9031-MAR-17€78,350.00
Bioavailability Study in PigsIndustry15-APR-0530-SEP-07€37,354.00
EI "A new versatile range of synthetic gene delivery vectors"Enterprise Irl01-JUL-0530-SEP-06€30,400.00
IRCSET PG "Non viral gene delivery"Irish Research Council for Science, Engineering & Technology (IRCSET)01-OCT-0531-MAR-09€80,915.00
Cyclodextrin-derived vectors for RNA interface and gene silencing PC/2006/202Enterprise Irl04-JUL-0603-NOV-07€103,445.00
Development of Taste Masking Platform TechnologiesEnterprise Irl10-JUL-0631-MAY-08€356,938.00
SFI ' Modified CD's as novel targeted¿for Cancer Therapy"Science Foundation of Ireland01-SEP-0628-FEB-10€141,500.00
Cancer Research Ireland "Systematic evaluation of the bioavailability and therapeutic efficacy of ."Miscellaneous01-OCT-0631-MAR-09€34,000.00
IRCSET PG "siRNA delivery in prostrate cancer"Irish Research Council for Science, Engineering & Technology (IRCSET)01-OCT-0730-SEP-10€74,586.00
SFI Oral & Pulmonary deliverary of peptides & genes - Irish Drug Delivery Research Network (IDDN)Science Foundation of Ireland01-DEC-0731-MAY-13€1,330,663.00
IRCSET PG Non Viral Delivery of siRNA - Student Aoife O'MahonyIrish Research Council for Science, Engineering & Technology (IRCSET)01-NOV-0831-OCT-12€72,009.00
EI - Cyclodextrin-derived vectors for RNAiEnterprise Irl01-APR-0901-OCT-11€542,188.00
SFI OIP 2010 Equipment & StaffScience Foundation of Ireland01-JAN-1031-DEC-11€28,065.00
Creating a Lipid Formulation Classification System.Foreign Research Institute01-NOV-1030-SEP-17€35,000.00
Pre-clinical development of stealth cyclodextrin siRNA nano-delivery systems for prostate cancer treatment.Irish Funded Research01-OCT-1131-DEC-15€282,013.00
New Oral Nanomedicines - Transporting Therapeutic Macromolecules across the Intestinal Barrier.European Union01-MAY-1230-APR-17€459,100.00
The use of non-Viral Vectors to effectively silence Genes in Primary and Metastatic Prostate Cancer Models.Irish Funded Research01-OCT-1230-SEP-16€136,980.00

Peer Reviewed Journals

YearPublication
(2016)'A novel, anisamide-targeted cyclodextrin nanoformulation for siRNA delivery to prostate cancer cells expressing the sigma-1 receptor'
Fitzgerald, KA;Malhotra, M;Gooding, M;Sallas, F;Evans, JC;Darcy, R;O'Driscoll, CM (2016) 'A novel, anisamide-targeted cyclodextrin nanoformulation for siRNA delivery to prostate cancer cells expressing the sigma-1 receptor'. International Journal of Pharmaceutics, 499 :131-145 [DOI] [Details]
(2016)'Pharmacokinetic, Pharmacodynamic and Biodistribution following oral administration of nanocarriers containing peptide and protein drugs'
Griffin, B.T>, Guo, J., Presas, E., Donovan, M.D., O'Driscoll, C.M. (2016) 'Pharmacokinetic, Pharmacodynamic and Biodistribution following oral administration of nanocarriers containing peptide and protein drugs'. Advanced Drug Delivery Reviews, Globe icon [DOI] [Details]
(2016)'Bioconjugated gold nanoparticles enhance cellular uptake: A proof of concept study for siRNA delivery in prostate cancer cells'
Guo J;O'Driscoll CM;Holmes JD;Rahme K; (2016) 'Bioconjugated gold nanoparticles enhance cellular uptake: A proof of concept study for siRNA delivery in prostate cancer cells'. International Journal of Pharmaceutics, 509 (1-2) [DOI] [Details]
(2016)'Anisamide-targeted gold nanoparticles for siRNA delivery in prostate cancer - synthesis, physicochemical characterisation and in vitro evaluation'
Fitzgerald, KA;Rahme, K;Guo, JF;Holmes, JD;O'Driscoll, CM (2016) 'Anisamide-targeted gold nanoparticles for siRNA delivery in prostate cancer - synthesis, physicochemical characterisation and in vitro evaluation'. Journal of Materials Chemistry B, 4 :2242-2252 [DOI] [Details]
(2016)'7-formyl-10-methylisoellipticine, a novel ellipticine derivative, induces mitochondrial reactive oxygen species (ROS) and shows anti-leukaemic activity in mice'
Russell, EG;Guo, JF;O'Sullivan, EC;O'Driscoll, CM;McCarthy, FO;Cotter, TG (2016) '7-formyl-10-methylisoellipticine, a novel ellipticine derivative, induces mitochondrial reactive oxygen species (ROS) and shows anti-leukaemic activity in mice'. Investigational new drugs, 34 :15-23 [DOI] [Details]
(2016)'Lipid-based nanocarriers for oral peptide delivery'
Niu Z;Conejos-Sánchez I;Griffin BT;O'Driscoll CM;Alonso MJ; (2016) 'Lipid-based nanocarriers for oral peptide delivery'. Advanced Drug Delivery Reviews, [DOI] [Details]
(2015)'The use of collagen-based scaffolds to simulate prostate cancer bone metastases with potential for evaluating delivery of nanoparticulate gene therapeutics'
Fitzgerald, KA;Guo, JF;Tierney, EG;Curtin, CM;Malhotra, M;Darcy, R;O'Brien, FJ;O'Driscoll, CM (2015) 'The use of collagen-based scaffolds to simulate prostate cancer bone metastases with potential for evaluating delivery of nanoparticulate gene therapeutics'. Biomaterials, 66 :53-66 [DOI] [Details]
(2015)'Delivering a Disease-Modifying Treatment for Huntington's Disease'
Godinho BMDC, Malhotra M, O’Driscoll CM, Cryan JF. (2015) 'Delivering a Disease-Modifying Treatment for Huntington's Disease'. Drug Discovery Today, 20 (1) [DOI] [Details]
(2015)'Synthesis and characterization of rabies virus glycoprotein-tagged amphiphilic cyclodextrins for siRNA delivery in human glioblastoma cells: in-vitro analysis'
Gooding M*, Malhotra M*, McCarthy DJ, Godinho BMDC, Cryan JF, Darcy R, O’Driscoll CM (2015) 'Synthesis and characterization of rabies virus glycoprotein-tagged amphiphilic cyclodextrins for siRNA delivery in human glioblastoma cells: in-vitro analysis'. European Journal of Pharmaceutical Science, [Details]
(2015)'Nanoparticles and the blood-brain barrier: advancing from in-vitro models towards therapeutic significance'
Mc Carthy DJ, Malhotra M, O'Mahony AM, Cryan JF, O'Driscoll CM (2015) 'Nanoparticles and the blood-brain barrier: advancing from in-vitro models towards therapeutic significance'. Pharmaceutical research, 32 (4):1161-1185 [DOI] [Details]
(2015)'Cyclodextrin mediated delivery of NF-kappa B and SRF siRNA reduces the invasion potential of prostate cancer cells in vitro'
Evans, JC;McCarthy, J;Torres-Fuentes, C;Cryan, JF;Ogier, J;Darcy, R;Watson, RW;O'Driscoll, CM (2015) 'Cyclodextrin mediated delivery of NF-kappa B and SRF siRNA reduces the invasion potential of prostate cancer cells in vitro'. Gene Therapy, 22 :802-810 [DOI] [Details]
(2015)'Evaluation of the physicochemical properties and the biocompatibility of polyethylene glycol-conjugated gold nanoparticles: A formulation strategy for siRNA delivery'
Rahme, K;Guo, JF;Holmes, JD;O'Driscoll, CM (2015) 'Evaluation of the physicochemical properties and the biocompatibility of polyethylene glycol-conjugated gold nanoparticles: A formulation strategy for siRNA delivery'. Colloids and Surfaces B-Biointerfaces, 135 :604-612 [DOI] [Details]
(2015)'Lipidic dispersion to reduce food dependent oral bioavailability of fenofibrate: In vitro, in vivo and in silico assessments'
O'Shea, JP;Faisal, W;Ruane-O'Hora, T;Devine, KJ;Kostewicz, ES;O'Driscoll, CM;Griffin, BT (2015) 'Lipidic dispersion to reduce food dependent oral bioavailability of fenofibrate: In vitro, in vivo and in silico assessments'. European Journal Of Pharmaceutics And Biopharmaceutics, 96 :207-216 [DOI] [Details]
(2015)'Positively charged, surfactant-free gold nanoparticles for nucleic acid delivery'
Guo, JF;Armstrong, MJ;O'Driscoll, CM;Holmes, JD;Rahme, K (2015) 'Positively charged, surfactant-free gold nanoparticles for nucleic acid delivery'. RSC Advances, 5 :17862-17871 [DOI] [Details]
(2015)'Exploring the Impact of Drug Properties on the Extent of Intestinal Lymphatic Transport - In Vitro and In Vivo Studies'
Lawless, E;Griffin, BT;O'Mahony, A;O'Driscoll, CM (2015) 'Exploring the Impact of Drug Properties on the Extent of Intestinal Lymphatic Transport - In Vitro and In Vivo Studies'. Pharmaceutical Research, 32 :1817-1829 [DOI] [Details]
(2015)'Synthesis and characterization of rabies virus glycoprotein-tagged amphiphilic cyclodextrins for siRNA delivery in human glioblastoma cells: In vitro analysis'
Gooding, M;Malhotra, M;McCarthy, DJ;Godinho, BMDC;Cryan, JF;Darcy, R;O'Driscoll, CM (2015) 'Synthesis and characterization of rabies virus glycoprotein-tagged amphiphilic cyclodextrins for siRNA delivery in human glioblastoma cells: In vitro analysis'. European Journal of Pharmaceutical Sciences, 71 :80-92 [DOI] [Details]
(2015)'Positively Charged, Surfactant-Free Gold Nanoparticles for Nucleic Acid Delivery'
Rahme K., Guo J., Armstrong M, O’Driscoll CM., Holmes JD (2015) 'Positively Charged, Surfactant-Free Gold Nanoparticles for Nucleic Acid Delivery'. RSC Advances, [Details]
(2015)'Lipidic dispersion to reduce food dependent oral bioavailability of fenofibrate: in vitro, in vivo and in silico assessments'
O'Shea, J.P.; Faisal, W; Ruane-O’Hora, T; Devine, K.J.; Kostewicz, E.S.; O'Driscoll, C.M.; Griffin, B.T. (2015) 'Lipidic dispersion to reduce food dependent oral bioavailability of fenofibrate: in vitro, in vivo and in silico assessments'. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 96 :207-216 Globe icon [DOI] [Details]
(2015)'RNAi therapeutics for brain cancer: current advancements in RNAi delivery strategies'
Malhotra M., Toulouse A., Godhino B.M.D.C., McCarthy D.J., Cryan J.F., O'Driscoll C.M. (2015) 'RNAi therapeutics for brain cancer: current advancements in RNAi delivery strategies'. Molecular Biosystems, 11 :2635-2657 Globe icon [DOI] [Details]
(2014)'Biomimetic nanoparticles for siRNA delivery in the treatment of leukaemia'
Guo J, Cahill MR, McKenna SL, O’Driscoll CM. (2014) 'Biomimetic nanoparticles for siRNA delivery in the treatment of leukaemia'. Biotechnology Advances, [DOI] [Details]
(2014)'PEGylated cyclodextrins as novel siRNA nanosystems: correlations between polyethylene glycol length and nanoparticle stability'
Godinho BM;Ogier JR;Quinlan A;Darcy R;Griffin BT;Cryan JF;O'Driscoll CM; (2014) 'PEGylated cyclodextrins as novel siRNA nanosystems: correlations between polyethylene glycol length and nanoparticle stability'. International Journal of Pharmaceutics, 473 (1-2) [DOI] [Details]
(2014)'The Role of Transcription Factors in Prostate Cancer and Potential for Future RNA Interference Therapy'
Fitzgerald K, Evans J, McCarthy J, Guo J, Prencipe M, Kearney M, Watson W, Caitriona M O’ Driscoll. (2014) 'The Role of Transcription Factors in Prostate Cancer and Potential for Future RNA Interference Therapy'. Expert Opinion on Therapeutic Targets, 18 (6):1-17 [Details]
(2014)'Biophysical and Structural Characterisation of Nucleic Acid Complexes with Modified Cyclodextrins Using Circular Dichroism'
O'Mahony, AM,Cronin, MF,Mcmahon, A,Evans, JC,Daly, K,Darcy, R,O'Driscoll, CM (2014) 'Biophysical and Structural Characterisation of Nucleic Acid Complexes with Modified Cyclodextrins Using Circular Dichroism'. Journal of Pharmaceutical Sciences, 103 :1346-1355 [DOI] [Details]
(2014)'Exploring the impact of drug properties on the extent of intestinal lymphatic transport - in vitro and in vivo studies'
Lawless E., Griffin BT., O’Mahony A., O’Driscoll CM. (2014) 'Exploring the impact of drug properties on the extent of intestinal lymphatic transport - in vitro and in vivo studies'. Pharmaceutical Research, Globe icon [DOI] [Details]
(2014)'Differential nanotoxicological and neuroinflammatory liabilities of non-viral vectors for RNA interference in the central nervous system'
Godinho BM, McCarthy DJ, Torres-Fuentes C, Beltrán CJ, McCarthy J, Quinlan A, Ogier JR, Darcy R, O'Driscoll CM, Cryan JF (2014) 'Differential nanotoxicological and neuroinflammatory liabilities of non-viral vectors for RNA interference in the central nervous system'. Biomaterials, 35 (1):489-499 [DOI] [Details]
(2013)'PEGylated gold nanoparticles: polymer quantification as a function of PEG lengths and nanoparticle dimensions'
Rahme, K.; Hobbs, R. G.; Chen, L.; Morris, M. A.; O’Driscoll, C.; Holmes, J. D. (2013) 'PEGylated gold nanoparticles: polymer quantification as a function of PEG lengths and nanoparticle dimensions'. RSC Advances, 3 (17):6085-6094 Globe icon [DOI] [CORA Link] [Details]
(2013)'Non-viral nanosystems for gene and small interfering RNA delivery to the central nervous system: formulating the solution'
O'Mahony AM, Godinho BM, Cryan JF, O'Driscoll CM (2013) 'Non-viral nanosystems for gene and small interfering RNA delivery to the central nervous system: formulating the solution'. Journal of pharmaceutical sciences, 102 (10):3469-3484 [DOI] [Details]
(2013)'Cationic and PEGylated Amphiphilic Cyclodextrins: Co-Formulation Opportunities for Neuronal Sirna Delivery'
O'Mahony AM, Ogier J, Darcy R, Cryan JF, O'Driscoll CM (2013) 'Cationic and PEGylated Amphiphilic Cyclodextrins: Co-Formulation Opportunities for Neuronal Sirna Delivery'. Plos One, 8 (6) [DOI] [Details]
(2013)'In vitro investigations of the efficacy of cyclodextrin-siRNA complexes modified with lipid-PEG-Octaarginine: towards a formulation strategy for non-viral neuronal siRNA delivery'
O'Mahony AM, Desgranges S, Ogier J, Quinlan A, Devocelle M, Darcy R, Cryan JF, O'Driscoll CM (2013) 'In vitro investigations of the efficacy of cyclodextrin-siRNA complexes modified with lipid-PEG-Octaarginine: towards a formulation strategy for non-viral neuronal siRNA delivery'. Pharmaceutical research, 30 (4):1086-1098 [DOI] [Details]
(2013)'Self-assembling modified ß-cyclodextrin nanoparticles as neuronal siRNA delivery vectors: focus on Huntington's disease'
Godinho BM, Ogier JR, Darcy R, O'Driscoll CM, Cryan JF (2013) 'Self-assembling modified ß-cyclodextrin nanoparticles as neuronal siRNA delivery vectors: focus on Huntington's disease'. Molecular pharmaceutics, 10 (2):640-649 [DOI] [Details]
(2013)'Highly Stable PEGylated Gold Nanoparticles in Water: Applications in Biology and Catalysis'
Rahme K., Nolan MT., Doody T., McGlacken GP., Morris MA., O’Driscoll C and Holmes JD. (2013) 'Highly Stable PEGylated Gold Nanoparticles in Water: Applications in Biology and Catalysis'. RSC Advances, 3 :21016-21024 [Details]
(2013)'Non-Viral Nanosystems for Gene and siRNA delivery to the Central Nervous System: Formulating the Solution'
O’Mahony AM,. Godinho BMDC, Cryan JF and O’Driscoll CM. (2013) 'Non-Viral Nanosystems for Gene and siRNA delivery to the Central Nervous System: Formulating the Solution'. Journal of Pharmaceutical Sciences, 102 :4369-4384 [Details]
(2012)'Characterisation of cationic amphiphilic cyclodextrins for neuronal delivery of siRNA: effect of reversing primary and secondary face modifications'
O'Mahony AM, Doyle D, Darcy R, Cryan JF, O'Driscoll CM (2012) 'Characterisation of cationic amphiphilic cyclodextrins for neuronal delivery of siRNA: effect of reversing primary and secondary face modifications'. European Journal of Pharmaceutical Sciences, 47 (5):896-903 [DOI] [Details]
(2012)'Click-modified cyclodextrins as nonviral vectors for neuronal siRNA delivery'
O'Mahony AM, Godinho BM, Ogier J, Devocelle M, Darcy R, Cryan JF, O'Driscoll CM (2012) 'Click-modified cyclodextrins as nonviral vectors for neuronal siRNA delivery'. ACS chemical neuroscience, 3 (10):744-752 [DOI] [Details]
(2012)'A click chemistry route to 2-functionalised PEGylated and cationic ß-cyclodextrins: co-formulation opportunities for siRNA delivery'
O'Mahony AM, Ogier J, Desgranges S, Cryan JF, Darcy R, O'Driscoll CM (2012) 'A click chemistry route to 2-functionalised PEGylated and cationic ß-cyclodextrins: co-formulation opportunities for siRNA delivery'. Organic & Biomolecular Chemistry, 10 (25):4954-4960 [DOI] [Details]
(1994)'The solubility and rate intestinal absorption of DDT in mixed micellar systems'
C.M. O'Driscoll, O.G. Obodozie and O.I. Corrigan. (1994) 'The solubility and rate intestinal absorption of DDT in mixed micellar systems'. European Journal of Drug Metabolism and Pharmacokinetics, 3 :74-78 [Details]
(2014)'PEGylated cyclodextrins as Novel siRNA nanosystems: correlations between polyethylene glycol length and nanoparticle stability'
Godinho BMDC, Ogier JR, Quinlan A, Darcy R, Griffin BT, Cryan JF, O’Driscoll CM. (2014) 'PEGylated cyclodextrins as Novel siRNA nanosystems: correlations between polyethylene glycol length and nanoparticle stability'. International Journal of Pharmaceutics, 473 :105-112 [Details]
(2014)'Comparison of in vitro tests at various levels of complexity for the prediction of in vivo performance of lipid-based formulations: case studies with fenofibrate'
Griffin BT, Kuentz M, Vertzoni M, Kostewicz ES, Fei Y, Faisal W, Stillhart C, O'Driscoll CM, Reppas C, Dressman JB (2014) 'Comparison of in vitro tests at various levels of complexity for the prediction of in vivo performance of lipid-based formulations: case studies with fenofibrate'. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 86 (3):427-437 [DOI] [Details]
(2014)'Early-Stage Development of Novel Cyclodextrin-siRNA Nanocomplexes Allows for Successful Postnebulization Transfection of Bronchial Epithelial Cells'
Hibbitts A, O’Mahony AM, Forde E, Nolan L, Ogier J, Desgranges S, Darcy R MacLoughlin R, O’Driscoll CM, Cryan SA. (2014) 'Early-Stage Development of Novel Cyclodextrin-siRNA Nanocomplexes Allows for Successful Postnebulization Transfection of Bronchial Epithelial Cells'. Journal Of Aerosol Medicine And Pulmonary Drug Delivery, :466-477 [DOI] [Details]
(2013)'Delivering RNAi therapeutics with non-viral technology: a promising strategy for prostate cancer?'
Guo J., Evans J and O’Driscoll CM. (2013) 'Delivering RNAi therapeutics with non-viral technology: a promising strategy for prostate cancer?'. Trends In Molecular Medicine, [Details]
(2013)'Nanostructures of cationic amphiphilic cyclodextrin complexes with DNA'
Villari, V., Mazzaglia, A., Darcy, R., O'Driscoll, CM and Micali, N. (2013) 'Nanostructures of cationic amphiphilic cyclodextrin complexes with DNA'. Biomacromolecules, 14 (3):811-817 [DOI] [Details]
(2013)'Amphiphilic polyallylamine based polymeric micelles for siRNA delivery to the gastrointestinal tract: in vitro investigations'
Guo J., O’Mahony AM., Cheng WP and O’Driscoll, CM (2013) 'Amphiphilic polyallylamine based polymeric micelles for siRNA delivery to the gastrointestinal tract: in vitro investigations'. International Journal of Pharmaceutics, 447 (1-2):150-157 [DOI] [Details]
(2013)'Cyclodextrins for Non-Viral Gene and siRNA Delivery'
O'Mahony AM., O’Neill MJ., Godinho BMDC., Darcy, R., Cryan, JF and; O'Driscoll, CM. (2013) 'Cyclodextrins for Non-Viral Gene and siRNA Delivery'. Pharmaceutical Nanotechnology, 1 :6-14 [CORA Link] [Details]
(2013)'Self-assembling Modified β-Cyclodextrin Nanoparticles as Neuronal siRNA Delivery Vectors: Focus on Huntington's Disease'
Godinho BM, Ogier JR, Darcy R, O'Driscoll CM, Cryan JF. (2013) 'Self-assembling Modified β-Cyclodextrin Nanoparticles as Neuronal siRNA Delivery Vectors: Focus on Huntington's Disease'. Molecular Pharmaceutics, 10 :640-649 [DOI] [Details]
(2013)'In Vitro Investigations of the Efficacy of Cyclodextrin-siRNA Complexes Modified with Lipid-PEG-Octaarginine: Towards a Formulation Strategy for Non-viral Neuronal siRNA Delivery'
O'Mahony, AM,Desgranges, S,Ogier, J,Quinlan, A,Devocelle, M,Darcy, R,Cryan, JF,O'Driscoll, CM (2013) 'In Vitro Investigations of the Efficacy of Cyclodextrin-siRNA Complexes Modified with Lipid-PEG-Octaarginine: Towards a Formulation Strategy for Non-viral Neuronal siRNA Delivery'. Pharmaceutical Research, 30 :1086-1098 [DOI] [Details]
(2013)'A novel lipid-based solid dispersion for enhancing oral bioavailability of Lycopene - In vivo evaluation using a pig model'
Faisal, W,Ruane-O'Hora, T,O'Driscoll, CM,Griffin, BT (2013) 'A novel lipid-based solid dispersion for enhancing oral bioavailability of Lycopene - In vivo evaluation using a pig model'. International Journal of Pharmaceutics, 453 :307-314 [DOI] [Details]
(2013)'Gene silencing of TNF-alpha in a murine model of acute colitis using a modified cyclodextrin delivery system'
McCarthy, J,O'Neill, MJ,Bourre, L,Walsh, D,Quinlan, A,Hurley, G,Ogier, J,Shanahan, F,Melgar, S,Darcy, R,O'Driscoll, CM (2013) 'Gene silencing of TNF-alpha in a murine model of acute colitis using a modified cyclodextrin delivery system'. Journal of controlled release : official journal of the Controlled Release Society, 168 :28-34 [DOI] [Details]
(2013)'Gastrointestinal gene delivery by cyclodextrins - In vitro quantification of extracellular barriers'
O'Neill, MJ,O'Mahony, AM,Byrne, C,Darcy, R,O'Driscoll, CM (2013) 'Gastrointestinal gene delivery by cyclodextrins - In vitro quantification of extracellular barriers'. International Journal of Pharmaceutics, 456 :390-399 [DOI] [Details]
(2012)'Pattern Recognition Receptors - Molecular orchestrators of Inflammation in Inflammatory Bowel Disease'
Walsh D, McCarthy J, O’ Driscoll CM and Melgar S. (2012) 'Pattern Recognition Receptors - Molecular orchestrators of Inflammation in Inflammatory Bowel Disease'. Cytokine & Growth Factor Reviews, [DOI] [Details]
(2012)'Click-modified cyclodextrins as non-viral vectors for neuronal siRNA delivery'
O'Mahony, AM, Godinho, BMDC, Ogier, J, Devocelle, M, Darcy, R, Cryan, JF, O'Driscoll, CM (2012) 'Click-modified cyclodextrins as non-viral vectors for neuronal siRNA delivery'. ACS Chemical Neuroscience, 10 (3):744-752 [DOI] [CORA Link] [Details]
(2013)'Cationic and PEGylated Amphiphilic Cyclodextrins: Co-Formulation Opportunities for Neuronal Sirna Delivery'
O'Mahony, AM,Ogier, J,Darcy, R,Cryan, JF,O'Driscoll, CM (2013) 'Cationic and PEGylated Amphiphilic Cyclodextrins: Co-Formulation Opportunities for Neuronal Sirna Delivery'. Plos One, 8 [DOI] [Details]
(2012)'Targeted gene delivery to hepatocytes with galactosylated amphiphilic cyclodextrins'
McMahon A., O’Neill MJ., Gomez E., Donohue R., Forde D., Darcy R., and O’Driscoll CM. (2012) 'Targeted gene delivery to hepatocytes with galactosylated amphiphilic cyclodextrins'. Journal of Pharmacy and Pharmacology, 54 :1063-1073 [DOI] [Details]
(2012)'Characterisation of cationic amphiphilic cyclodextrins for neuronal delivery of siRNA: Effect of reversing primary and secondary face modifications'
O'Mahony AM, Doyle D, Darcy R, Cryan JF, O'Driscoll CM. (2012) 'Characterisation of cationic amphiphilic cyclodextrins for neuronal delivery of siRNA: Effect of reversing primary and secondary face modifications'. European Journal of Pharmaceutical Sciences, 47 (5):896-903 [DOI] [CORA Link] [Details]
(2012)'Anisamide-targeted cyclodextrin nanoparticles for siRNA delivery to prostate tumours in mice'
Guo J., Ogier J., Desgranges S., Darcy R., and O’Driscoll CM. (2012) 'Anisamide-targeted cyclodextrin nanoparticles for siRNA delivery to prostate tumours in mice'. Biomaterials, 33 (31):7775-7784 Globe icon [DOI] [CORA Link] [Details]
(2012)'Systemic delivery of therapeutic small interfering RNA using a pH-triggered amphiphilic poly-L-lysine nanocarrier to suppress prostate cancer growth in mice'
Guo J., Cheng WP., Gu J., Ding C., Qu X., Yang Z., and O’Driscoll CM (2012) 'Systemic delivery of therapeutic small interfering RNA using a pH-triggered amphiphilic poly-L-lysine nanocarrier to suppress prostate cancer growth in mice'. European Journal of Pharmaceutical Sciences, 45 (5):521-532 [DOI] [CORA Link] [Details]
(2012)'A click chemistry route to 2-functionalised PEGylated and cationic beta-cyclodextrins: co-formulation opportunities for siRNA delivery'
O'Mahony, AM,Ogier, J,Desgranges, S,Cryan, JF,Darcy, R,O'Driscoll, CM (2012) 'A click chemistry route to 2-functionalised PEGylated and cationic beta-cyclodextrins: co-formulation opportunities for siRNA delivery'. Organic & Biomolecular Chemistry, 10 :4954-4960 [DOI] [CORA Link] [Details]
(2012)'Characterisation of cationic amphiphilic cyclodextrins for neuronal delivery of siRNA: Effect of reversing primary and secondary face modifications'
O'Mahony, AM,Doyle, D,Darcy, R,Cryan, JF,O'Driscoll, CM (2012) 'Characterisation of cationic amphiphilic cyclodextrins for neuronal delivery of siRNA: Effect of reversing primary and secondary face modifications'. European Journal of Pharmaceutical Sciences, 47 :896-903 [DOI] [Details]
(2011)'Intestinal delivery of non-viral gene therapeutics: physiological barriers and preclinical models'
O’Neill JM, Bourre L, Melgar S, O’Driscoll CM. (2011) 'Intestinal delivery of non-viral gene therapeutics: physiological barriers and preclinical models'. Drug Discovery Today, :203-218 [DOI] [Details]
(2011)'Mechanistic studies on the uptake and intracellular trafficking of novel cyclodextrin transfection complexes by intestinal epithelial cells'
Martin J. O¿ Neill, Jianfeng Guo, Colin Byrne, Raphael Darcy and Caitriona M. O¿ Driscoll; (2011) 'Mechanistic studies on the uptake and intracellular trafficking of novel cyclodextrin transfection complexes by intestinal epithelial cells'. International Journal of Pharmaceutics, 413 (1-2):174-183 Globe icon [DOI] [CORA Link] [Details]
(2011)'Intestinal Delivery of Non-viral Gene Therapeutics- Physiological Barriers & Pre-clinical Models'
Martin J. O'Neill, Ludovic Bourre, Silvia Melgar, and Caitriona M. O'Driscoll.; (2011) 'Intestinal Delivery of Non-viral Gene Therapeutics- Physiological Barriers & Pre-clinical Models'. Drug Discovery Today, 16 (5/6):203-218 [DOI] [Details]
(2011)'Opportunities and challenges for oral delivery of hydrophobic versus hydrophilic peptide and protein-like drugs using lipid-based technologies'
Griffin BT, O'Driscoll CM (2011) 'Opportunities and challenges for oral delivery of hydrophobic versus hydrophilic peptide and protein-like drugs using lipid-based technologies'. Therapeutic Delivery, 2 (12):1633-1653 [Details]
(2011)'Can non-viral technologies knockdown the barriers to siRNA delivery and achieve the next generation of cancer therapeutics?'
Jianfeng Guo, Ludovic Bourre, Declan M. Soden, Gerald C. O'Sullivan, Caitriona O'Driscoll; (2011) 'Can non-viral technologies knockdown the barriers to siRNA delivery and achieve the next generation of cancer therapeutics?'. Biotechnology Advances, 29 (4):402-417 Globe icon [DOI] [CORA Link] [Details]
(2010)'Therapeutic targeting in the silent era: advances in non-viral siRNA delivery'
Guo, J; Fisher, KA; Darcy, R; Cryan, JF; O'Driscoll, C; (2010) 'Therapeutic targeting in the silent era: advances in non-viral siRNA delivery'. Molecular Biosystems, 6 (7):1143-1161 [DOI] [CORA Link] [Details]
(2010)'Bioavailability of lycopene in the rat: the role of intestinal lymphatic transport'
Faisal, W; O'Driscoll, CM; Griffin, BT; (2010) 'Bioavailability of lycopene in the rat: the role of intestinal lymphatic transport'. Journal of Pharmacy and Pharmacology, 62 (3):323-331 [DOI] [Details]
(2008)'Biopharmaceutical challenges associated with drugs with low aqueous solubility - the potential impact of lipid-based formulations'
O’Driscoll CM and Griffin BT (2008) 'Biopharmaceutical challenges associated with drugs with low aqueous solubility - the potential impact of lipid-based formulations'. Advanced Drug Delivery Reviews, :617-624 [DOI] [Details]
(2008)'Comparison of drug transporter gene expression and functionality in Caco-2 cells from 10 different laboratories'
Hayeshi R, Hilgendorf C, Artursson P, Augustijns P, Brodin B, Dehertogh P, Fisher K, Fossati L, Hovenkamp E, Korjamo T, Masungi C, Maubon N, Mols R, Müllertz A, Mönkkönen J, O'Driscoll C, Oppers-Tiemissen HM, Ragnarsson EG, Rooseboom M, Ungell AL.; (2008) 'Comparison of drug transporter gene expression and functionality in Caco-2 cells from 10 different laboratories'. European Journal of Pharmaceutical Sciences, 35 (5):383-396 [Details]
(2008)'Cyclodextrin Gene Vectors: Cell Trafficking and The Influence of Lipophilic Chain Length'
McMahon, A, Gomez, E, Donohue, R, Forde, D, Darcy, R, O'Driscoll, CM; (2008) 'Cyclodextrin Gene Vectors: Cell Trafficking and The Influence of Lipophilic Chain Length'. Journal of Drug Delivery Science and Technology, 18 (5):303-307 [Details]
(2008)'An Examination of the Effect of Intestinal First Pass Extraction on Intestinal Lymphatic Transport of Saquinavir in the Rat'
Griffin, B.T. and O’Driscoll, C.M.; (2008) 'An Examination of the Effect of Intestinal First Pass Extraction on Intestinal Lymphatic Transport of Saquinavir in the Rat'. Pharmaceutical Research, 25 (5):1125-1133 Globe icon [DOI] [Details]
(2006)'A comparison of intestinal lymphatic transport and systemic bioavailability of saquinavir from three lipid-based formulations in the anaesthetised rat model'
Griffin BT, O'Driscoll CM; (2006) 'A comparison of intestinal lymphatic transport and systemic bioavailability of saquinavir from three lipid-based formulations in the anaesthetised rat model'. Journal of Pharmacy and Pharmacology, 58 (7):917-925 [DOI] [Details]
(2006)'Evaluation of Cellular Uptake and Gene Transfer Efficiency of Pegylated Poly-L-Lysine Compacted Dna: Implications For Cancer Gene Therapy'
Walsh, M, Tangney, M, O'Neill, MJ, Larkin, JO, Soden, DM, McKenna, SL, Darcy, R, O'Sullivan, GC, O'Driscoll, CM; (2006) 'Evaluation of Cellular Uptake and Gene Transfer Efficiency of Pegylated Poly-L-Lysine Compacted Dna: Implications For Cancer Gene Therapy'. Molecular Pharmaceutics, 3 (6):644-653 [DOI] [Details]
(2005)'Quantitative estimation of the effects of bile salt surfactant systems on insulin stability and permeability in the rat intestine using a mass balance model'
Lane ME, O'driscoll CM, Corrigan OI; (2005) 'Quantitative estimation of the effects of bile salt surfactant systems on insulin stability and permeability in the rat intestine using a mass balance model'. Journal of Pharmacy and Pharmacology, 57 (2):169-175 [Details]
(2004)'Cationic cyclodextrin amphiphiles as gene delivery vectors'
Cryan S.A., Donohue R., Ravoo B.J., Darcy R., O'Driscoll C.M.; (2004) 'Cationic cyclodextrin amphiphiles as gene delivery vectors'. Journal of Drug Delivery Science and Technology, 14 (1):57-62 [Details]
(2004)'Cell transfection with polycationic cyclodextrin vectors'
Cryan S.A., Holohan A., Donohue R., Darcy R., O'Driscoll C.M.; (2004) 'Cell transfection with polycationic cyclodextrin vectors'. European Journal of Pharmaceutical Science, 21 (*):625-633 [Details]
(2004)'Stimulation of triglyceride rich lipoprotein secretion by polysorbate 80: in vtiro and in vivo correlation using Caco-2 cells and a cannulated rat intestinal lymphatic model'
Seeballuck F., Lawless E., Ashford M.B., O'Driscoll C.M.; (2004) 'Stimulation of triglyceride rich lipoprotein secretion by polysorbate 80: in vtiro and in vivo correlation using Caco-2 cells and a cannulated rat intestinal lymphatic model'. Pharmaceutical Research, 21 (12):2320-2326 [Details]
(2003)'The effects of casein on diclofenac release from hydroxypropylmethylcellulose (HPMC) compacts'
Gubinns R.H., O'Driscoll C.M., Corrigan O.I.; (2003) 'The effects of casein on diclofenac release from hydroxypropylmethylcellulose (HPMC) compacts'. International Journal of Pharmaceutics, 260 (1):69-76 [Details]
(2003)'Intestinal lymphatic targeting of drugs'
O'Driscoll C.M.; (2003) 'Intestinal lymphatic targeting of drugs'. STP Pharma Sciences, 13 (1):17-25 [Details]
(2003)'The effects of pluronic block copolymers and Cremophor EL on intestinal lipoprotein processing and the potential link with P-glycoprotein in Caco-2 cells'
Seeballuck F., Asford M.B., O'Driscoll C.M.; (2003) 'The effects of pluronic block copolymers and Cremophor EL on intestinal lipoprotein processing and the potential link with P-glycoprotein in Caco-2 cells'. Pharmaceutical Research, 20 (7):1085-1092 [Details]
(2003)'Estimation of absorption parameters from the non-steady-state phase in the rat gut perfusion model'
Corrigan O.I., Gubbins R.H., O'Driscoll C.M.; (2003) 'Estimation of absorption parameters from the non-steady-state phase in the rat gut perfusion model'. Journal of Pharmacy and Pharmacology, 55 (4):487-493 [Details]
(2003)'Mechanistic studies on nonviral gene delivery to the intestine using in vitro differentiated cell cuture models and in vivo rat intestinal loop'
Cryan S.A., O'Driscoll C.M.; (2003) 'Mechanistic studies on nonviral gene delivery to the intestine using in vitro differentiated cell cuture models and in vivo rat intestinal loop'. Pharmaceutical Research, 20 (4):569-575 [Details]
(2002)'Lipid-based formulations for intestinal lymphatic delivery'
O'Driscoll CM; (2002) 'Lipid-based formulations for intestinal lymphatic delivery'. European Journal of Pharmaceutical Sciences, 15 (5):405-415 [Details]
(2000)'A comparison of the permeation enhancement potential of simple bile salt and mixed bile salt:fatty acid micellar systems using the CaCo-2 cell culture model'
Meaney CM, O'Driscoll CM; (2000) 'A comparison of the permeation enhancement potential of simple bile salt and mixed bile salt:fatty acid micellar systems using the CaCo-2 cell culture model'. International Journal of Pharmaceutics, 207 ((1-2)):21-30 [Details]
(1999)'Mucus as a barrier to the permeability of hydrophilic and lipophilic compounds in the absence and presence of sodium taurocholate micellar systems using cell culture models'
Meaney C, O'Driscoll C; (1999) 'Mucus as a barrier to the permeability of hydrophilic and lipophilic compounds in the absence and presence of sodium taurocholate micellar systems using cell culture models'. European Journal of Pharmaceutical Sciences, 8 (3):167-175 [Details]
(1996)'The relationship between rat intestinal permeability and hydrophilic probe size'
Lane ME, O'Driscoll CM, Corrigan OI; (1996) 'The relationship between rat intestinal permeability and hydrophilic probe size'. Pharmaceutical Research, 13 (10):1554-1558 [Details]
(1994)'The effect of mixed micellar systems, bile salt/fatty acids, on the solubility and intestinal absorption of clofazimine (B663) in the anaesthetised rat'
Joan R. O'Reilly, Owen I. Corrigan and Caitriona M. O'Driscoll; (1994) 'The effect of mixed micellar systems, bile salt/fatty acids, on the solubility and intestinal absorption of clofazimine (B663) in the anaesthetised rat'. International Journal of Pharmaceutics, 109 (2):147-154 [Details]
(1994)'The effect of simple micellar systems on the solubility and intestinal absorption of clofazimine (B663) in the anaesthetised rat'
Joan R. O'Reilly, Owen I. Corrigan and Caitriona M. O'Driscoll; (1994) 'The effect of simple micellar systems on the solubility and intestinal absorption of clofazimine (B663) in the anaesthetised rat'. International Journal of Pharmaceutics, 105 (2):137-146 [Details]
(1991)'Blood and lymph transport of DDT after oral and parenteral administration to anaesthetised rats'
Caitriona M. O'Driscoll Robert A. Myers and Valentino J. Stella; (1991) 'Blood and lymph transport of DDT after oral and parenteral administration to anaesthetised rats'. International Journal of Pharmaceutics, 73 (2):177-183 [Details]
(1991)'A comparison of the effect of synthetic and naturally occurring surfactants on the solubility and absorption of clofazimine (B 663)'
O'Driscoll CM, O'Reilly JR, Corrigan OI; (1991) 'A comparison of the effect of synthetic and naturally occurring surfactants on the solubility and absorption of clofazimine (B 663)'. European Journal of Drug Metabolism and Pharmacokinetics, :116-119 [Details]
(1983)'The influence of perfusion rate on salicylate absorption in the rat'
O'Driscoll KM, Corrigan OI.; (1983) 'The influence of perfusion rate on salicylate absorption in the rat'. Journal of Pharmacy and Pharmacology, 35 (12):814-815 [Details]
(1982)'Chlorothiazide-Polyvinylpyrrolidone (PVP) Interactions: Influence on Membrane Permeation (Everted Rat Intestine) and Dissolution'
O'Driscoll KM, Corrigan OI.; (1982) 'Chlorothiazide-Polyvinylpyrrolidone (PVP) Interactions: Influence on Membrane Permeation (Everted Rat Intestine) and Dissolution'. Drug Development and Industrial Pharmacy, 8 (4):547-564 [Details]
(1980)'The effect of dosage on the bioavailability of chlorothiazide administered in solution'
Corrigan OI, O'Driscoll KM.; (1980) 'The effect of dosage on the bioavailability of chlorothiazide administered in solution'. Journal of Pharmacy and Pharmacology, 32 (8):547-549 [Details]

Conference Publications

YearPublication
(2011)38th Annual Meeting of Controlled Release Society
F. F. Farag, M. I. Amaro, A.M. Healy, C. M. O¿Driscoll, A. M. Crean; (2011) Stability of Salmon Calcitonin-Sugar Nanoporous Microparticles 38th Annual Meeting of Controlled Release Society National Harbor, Maryland, U.S.A, [Details]
(2010)American Association of Pharmaceutical Scientists (AAPS) Annual Conference
O'Mahony, AM; Ogier, J; O'Neill, M; Darcy, R; Cryan, JF; O'Driscoll, CM; (2010) Cyclodextrin-based vectors for siRNA delivery: Effects of pegylation on physical and biological properties in vitro American Association of Pharmaceutical Scientists (AAPS) Annual Conference [Details]
(2010)All-Ireland School of Pharmacy Conference. Queens University, Belfast
O'Mahony, A; Ogier, J; Doyle, D; Darcy, R; Cryan, JF; O'Driscoll, CM; (2010) Modified cyclodextrins as siRNA delivery vectors for neuronal and non-neuronal cells: A study of different structural modifications All-Ireland School of Pharmacy Conference. Queens University, Belfast [Details]
(2010)Annual Meeting of American Society of Gene and Cell Therapy
Guo, Jianfeng; Thompson, Colin J; Ping Cheng, Woei; O'Driscoll, Catriona; (2010) Novel comb shaped amphiphilic polyallylamine for potential oral delivery of siRNA to gastrointestinal cancers: physicochemical characterization and in vitro evaluation Annual Meeting of American Society of Gene and Cell Therapy [Details]
(2010)Neuroscience Ireland Annual Conference 2010
Godinho, BMDC; O'Mahony, AM; Ogier, JR; Darcy, R; O'Driscoll, CM; Cryan, JF; (2010) Cyclodextrins as nonviral-vectors for siRNA delivery to the central nervous system Neuroscience Ireland Annual Conference 2010 [Details]
(2010)AAPS National Biotechnology Conference
Farag, F.F., O'Driscoll, C.M., Crean, A.M.; (2010) Formulation and storage conditions affecting the conformation and degradation of salmon calcitonin delivery systems AAPS National Biotechnology Conference San Francisco, [Details]
(2009)International Society for Cell and Gene Therapy of Cancer
Guo J, Cheng WP, Qu X, Gu J, Ding C, Yang Z, O'Driscoll CM; (2009) pH-triggered amphiphilic poly-L-lysone micelles for passive targetd delivery of siRNA to cancer cells: physicochemical characterisations and in vitro evaluations International Society for Cell and Gene Therapy of Cancer [Details]
(2009)American Association of Pharmaceutical Scientists (AAPS) Annual Conference
Martin O¿ Neill, Colin Byrne , Raphael Darcy , and Caitriona O¿ Driscoll.; (2009) Mechanistic Studies Investigating Binding and Uptake of Amphiphilic Cyclodextrin.DNA Nanoparticles by Caco-2 cells American Association of Pharmaceutical Scientists (AAPS) Annual Conference [Details]
(2009)Molecules to Medicine Research Conference
Martin O¿ Neill, Colin Byrne , Raphael Darcy , and Caitriona O¿ Driscoll.; (2009) Cyclodextrin Mediated Gene Delivery to the Intestine ¿ Predicting Cellular Uptake Pathways and Transfection Complex Stability Molecules to Medicine Research Conference [Details]
(2008)XVIth Annual Congress of the European Society of Gene and Cell Therapy
J.Guo, J. Ogier, R.Darcy and C.M.O¿Driscoll; (2008) Synthesis of Anisic-targeted cyclodextrin for siRNA delivery to cancer cells XVIth Annual Congress of the European Society of Gene and Cell Therapy Brugge, Belgium, [Details]
(2008)Irish Society for Gene & Cell Therapy Conference
J Guo, K Fisher, M. O¿Neill, R. Darcy and C. M. O¿Driscoll; (2008) Investigation of novel anisamide-targeted stealth cyclodextrin nanoparticles for siRNA delivery in prostate cancer Irish Society for Gene & Cell Therapy Conference Cork, Ireland, [Details]
(2008)British Society for Gene Therapy 5th Annual Conference
K.A.Fisher, F.Sallas, R.Darcy and C.M.O'Driscoll; (2008) Characterisation of Folate and Guanidino Modified Cyclodextrins as Non-viral Vectors for siRNA Delivery to Tumour Cells British Society for Gene Therapy 5th Annual Conference Edniburgh, [Details]
(2008)30th All Ireland Schools of Pharmacy Research Seminar
K.A.Fisher, F.Sallas, R.Darcy and C.M.O'Driscoll; (2008) Folate and Guanidino Modified Cyclodextrins as Non-viral Vectors for siRNA Delivery 30th All Ireland Schools of Pharmacy Research Seminar University College Cork, [Details]
(2008)Irish Society for Gene and Cell Therapy Conference
O¿ Neill M, Walsh M, Byrne C, Darcy R, O¿ Driscoll CM; (2008) Investigating barriers to cyclodextrin mediated gene delivery to the intestine Irish Society for Gene and Cell Therapy Conference [Details]
(2008)Unknown
O'Driscoll, CM ; (2008) Delivery of siRNA: challenges and opportunities Unknown [Details]
(2008)CRS Annual Meeting
O¿ Neill M, Walsh M, Byrne C, Darcy R, O¿ Driscoll CM; (2008) The Effect of Simulated Intestinal Fluid on the Stability and Efficacy of a Novel Cyclodextrin Gene Delivery Vector CRS Annual Meeting New York, USA, [Details]
(2008)American Association of Pharmaceutical Scientists (AAPS)
Faisal, W., O'Driscoll, C.M., Griffin, B.T.; (2008) Solubility and Stability of lycopene in lipid based formulations American Association of Pharmaceutical Scientists (AAPS) [Details]
(2008)UK & Ireland Controlled Release Society (UKICRS)
Faisal, W., O'Driscoll, C.M., Griffin, B.T.; (2008) Investigation of Lycopene absorption mechanisms from the Gastro-intestinal tract of the rat UK & Ireland Controlled Release Society (UKICRS) [Details]
(2007)XV Annual Congress of the European Society of Gene and Cell Therapy
K.A.Fisher, C.Noone, F.Sallas, R.Darcy and C.M.O'Driscoll; (2007) Modified cyclodextrins as novel targeted formulations to deliver siRNA XV Annual Congress of the European Society of Gene and Cell Therapy Rotternam, Holland, [Details]
(2007)Formulation and characterisation of a novel cyclodextrin gene delivery vector
O¿ Neill M, Walsh M, Byrne C, Darcy R, and O¿ Driscoll CM; (2007) Abstract at the American Society of Gene Therapy Formulation and characterisation of a novel cyclodextrin gene delivery vector Seattle, USA, [Details]
(2007)All Ireland School of Pharmacy Conference
Faisal W, O'Driscoll CM, Griffin BT; (2007) Comparison of the intestinal lymphatic transport of lycopene in anaesthetised rat from a range of lipid based formulations All Ireland School of Pharmacy Conference Dublin, Ireland, [Details]
(2007)XVth Annual Congress of the European Society of Gene and Cell Therapy
M. O'Neill, J. Guo, K. Fisher, M. Walsh, C. Byrne, R. Darcy, C.M. O¿Driscoll; (2007) Amphiphilic Cationic Cyclodextrins as Non-Viral Vectors for Gene and siRNA Delivery XVth Annual Congress of the European Society of Gene and Cell Therapy Rotternam, Holland, [Details]
(2007)Excipient Fest Ireland
Faisal W, O'Driscoll CM, Griffin BT; (2007) Comparison of the intestinal lymphatic transport of lycopene in anaesthetised rat Excipient Fest Ireland Cork, Ireland, , 19-JUN-07 - 20-JUN-07 [Details]
(2007)American Society of Gene Therapy
O¿ Neill M, Walsh M, Byrne C, Darcy R, and O¿ Driscoll CM; (2007) Formulation and characterisation of a novel cyclodextrin gene delivery vector American Society of Gene Therapy [Details]
(2007)Unknown
O¿Driscoll CM.; (2007) Current / future prospects of in-vitro/in-vivo correlations for lipid formulations Unknown , pp.25-29 [Details]
(2006)UK and Ireland Controlled Release Society Meeting, Astrazeneca R & D
O¿Neill MJ, Walsh M. Byrne CP, Darcy R and O¿Driscoll CM; (2006) Characterisation of novel amphiphilic polycationic cyclodextrins as non-viral vehicles for gene delivery UK and Ireland Controlled Release Society Meeting, Astrazeneca R & D Loughburough, U.K, [Details]
(2005)Annual CRS meeting
Walsh M, O¿Sullivan G, O¿Driscoll CM; (2005) Characterisation of a poly-L-lysine based non-viral gene therapy system Annual CRS meeting Miami, USA, [Details]
(2005)3rd World Conference on Drug Absorption, Transport and Delivery (EUFEPS)
Walsh M, Frkanec L, Hammond L, Darcy R, O¿Sullivan G, O¿Driscoll CM; (2005) An amphiphilic polycationic cyclodextrin transfects post-mitotic intestinal cells 3rd World Conference on Drug Absorption, Transport and Delivery (EUFEPS) Barcelona, Spain, [Details]
(2004)Amer Assoc Pharm Sci., (AAPS) Annual meeting
Lawless E and O¿Driscoll CM; (2004) Effect of cyclosporine dose on intestinal lymphatic triglyceride output and lymphatic transport in the mesenteric lymph duct cannulated rat model Amer Assoc Pharm Sci., (AAPS) Annual meeting Baltimore, USA, [Details]
(2004)Amer Assoc Pharm Sci., (AAPS) Annual meeting
Griffin BT, Lawless E and O¿Driscoll CM; (2004) Comparision of the degree of lymphatic transport of a range of lipophilic compounds in the presence of an oleic acid based microemulsion Amer Assoc Pharm Sci., (AAPS) Annual meeting Baltimore, USA, [Details]
(2003)Amer Assoc Pharm Sci., Annual meeting
McMahon, A, Donohue R, Forde D, Darcy R, O¿Driscoll CM; (2003) Hyrophobicity and ligand linker-length affect transfection efficiency of targeted amphiphilic cyclodextrins as gene delivery vectors Amer Assoc Pharm Sci., Annual meeting Salt Lake City, USA, [Details]
(2003)Amer Assoc Pharm Sci., (AAPS) Annual meeting
Lawless E, Seeballuck F, O¿Driscoll CM; (2003) Secretion of intestinal triglyceride in response to lipid-based formulations ¿ A comparison of in vitro Caco-2 and in vivo rat intestinal lymphatic data Amer Assoc Pharm Sci., (AAPS) Annual meeting Salt Lake City, USA, [Details]
(2003)Annual CRS meeting
McMahon, A, Donohue R, Forde D, Darcy R, O¿Driscoll CM; (2003) The role of helper lipid DOPE in novel cyclodextrin/DNA constructs for hepatic-targeted gene delivery Annual CRS meeting Glasgow, UK, [Details]

Book Chapters

YearPublication
(2012)'Nanostructures Overcoming the Intestinal Barrier: Physiological Considerations and Mechanistic Issues'
Maher, Sam; Ryan, Katie B.; Ahmad, Tauseef; O’Driscoll, Caitriona M.; Brayden, David J. (2012) 'Nanostructures Overcoming the Intestinal Barrier: Physiological Considerations and Mechanistic Issues' In: Nanostructured Biomaterials for Overcoming Biological Barriers. London: RSC. [DOI] [Details]
(2008)'Models of the small intestine'
Brendan Griffin and Caitriona O'Driscoll; (2008) 'Models of the small intestine' In: Drug absorption studies - in situ, in vitro, and in silico models. New York: Springer. [Details]
(1996)'Carbenoxolone Sodium'
Pindado, O.I., Corrigan O.I, O'Driscoll C.M.; (1996) 'Carbenoxolone Sodium' In: Analytical Profiles of Drug Substances and Excipients. [Details]
(1992)'Anatomy/Physiology of the Lymph'
O'Driscoll C.M.; (1992) 'Anatomy/Physiology of the Lymph' In: Lymphatic Transport of Drugs. [Details]
(1992)'Clofazimine'
O'Driscoll C.M. and Corrigan O.I.; (1992) 'Clofazimine' In: Analytical Profiles of Drug Substances and Excipients. [Details]

Honours and Awards

 YearTitleAwarding Body
2013Parenteral Drug Association 'Person of the Year' award Parenteral Drug Association (Ireland Chapter)
2007Helix Health Pharmacist Award for Professional Excellence. unknown
2007Helix Health Pharmacist Award of Pharmacist of the Year. unknown

Professional Associations

 AssociationFunctionFrom / To
Health Products Regulatory Authority Board Member01-JAN-11 / 30-JUN-15
Pharmaceutical Society of Ireland Member01-JAN-11 / 30-JUN-15
Controlled Release Society *01-MAY-03 / 02-APR-10
American Association of Pharmaceutical Scientists *30-DEC-99 / 01-OCT-13

Committees

 CommitteeFunctionFrom / To
National Forum for Pharmacy Education and Accreditation Member of forum2011 / 2013
Pharmaceutical Sciences World Congress for European and African Region - Amsterdam 2007 Publicity Committee2004 / 1899
2nd International Symposium on Science and Regulatory Aspects of Dissolution and Bioequivalence - Athens June 05 Science Planning Committee2004 / 1899
European Drug Absorption Network (EDAN) Member of Organising Committee2008 / 2015
Poisons Council Unknown2000 /
Pharmaceutical Society of Ireland Adjudicating Committee1998 / 2001
Pharmaceutical Society of Ireland Council Member1994 / 1997

Employment

 EmployerPositionFrom / To
UCC Professor of Pharmaceutics01-JUL-03 / 30-DEC-99
TCD Senior Lecturer in Pharmaceutics01-APR-95 / 30-JUN-03
University of Kansas, USA Research Sabbatical01-JAN-88 / 31-DEC-88
TCD Lecturer in Pharmaceutics01-SEP-77 / 01-JUL-95

Education

 YearInstitutionQualificationSubject
1983University of Dublin, Trinity College PhD
1981University of Dublin, Trinity College MA (Jure officii)
1976University College Dublin BSc Pharm

Journal Activities

 JournalRoleTo / From
Journal Of Drug Delivery Science And Technology Member of Editorial Board01-JAN-02 -
Journal Of Pharmacy And Pharmacology Editor01-JAN-00 -
Journal Of Pharmaceutical Sciences Member of Editorial Board01-JAN-03 -
European Journal Of Pharmaceutical Science Member of Editorial Board01-JAN-03 -
Biopharmaceutics And Drug Disposition Member of Editorial Board01-JAN-03 -
Pharmaceutical Research Referee-
European Journal Of Pharmaceutical Science Referee-
Journal Of Drug Delivery Science And Technology Referee-
International Journal Of Pharmaceutics Referee-

Teaching Interests

Teaching Interests:

Prof. O'Driscoll currently teaches various aspects of Pharmaceutics to all levels of under-graduate B. Pharmacy students including PF1012, PF3008, PF4109.
At postgraduate level she teaches modules in the MSc Biotechnology and MSc Pharmaceutical Technology and Quality Systems   


Current Postgraduate Students

 StudentDegree Type
Evans James Christopher Doctoral Degree

Modules Taught

 Term (ID))TitleLinkSubject
2017Pharmaceutical Development of Investigational Medicinal Products PF6204Pharmaceutical Development of Investigational Medicinal Products
2017Pharmaceutical Biotechnology PF6205Pharmaceutical Biotechnology
2017Pharmaceutical Biotechnology PF4109Pharmaceutical Biotechnology
2017Biopharmaceutics and Pharmacokinetics PF3008Biopharmaceutics and Pharmacokinetics