Total Career Publications: 135. Google Scholar H-Index: 48, citations 7214; Scopus H-Index: 43, citations 5486.
Total Career Research Income: Euro 10.5M. PhDs Graduated (Career): 25 PhDs
She received a B.Sc. in Pharmacy from University College Dublin in 1976 and a PhD in 1983 from the University of Dublin, Trinity College. In 1977 she joined the faculty of the School of Pharmacy in Trinity College and held the posts of lecturer (1977-1994) and senior lecturer (1995-2003) in Pharmaceutics during which time she undertook a sabbatical in the Department of Pharmaceutical Chemistry at the University of Kansas. In 2003 she was appointed as Professor of Pharmaceutics at UCC and was, at the same time, appointed as the first Head of the School of Pharmacy at UCC, she served as Head from 2003-09 and 2010-13.During her tenure as Professor of Pharmaceutics she has established an energetic, productive and expanding drug delivery research team. The expertise established spans from pre-formulation through to production and manufacture of prototype delivery systems suitable for clinical trial. The group has obtained funding from exchequer and non-exchequer sources and offers a range of PhD positions. Strong links to the Pharmaceutical Industry underpin many of the research projects. The establishment within UCC of the drug delivery group and the development of interactions with Pharmaceutical Chemistry and Process & Chemical Engineering at UCC gives the University a unique strength which facilitates drug development research from drug design and synthesis all the way through formulation and production to clinical trial.
Professor O'Driscoll has published peer-reviewed research articles in key pharmaceutical journals, including Journal of Controlled Release, Molecular Pharmaceutics, and Pharmaceutical Research. She has been invited to give lectures at various international conferences and institutions worldwide and is a member of the Editorial Advisory Board for several journals including European Journal of Pharmaceutical Sciences, Journal of Pharmaceutical Sciences, Journal of Pharmacy and Pharmacology, Journal of Drug Delivery, Science and Technology and Pharmaceutical Nanotechnology.
Professor O'Driscoll is an external examiner for University of Bath, Masters in Pharmacy and for the Pharmaceutical Society of Ireland, Professional Registration examination. She has acted as PhD thesis examiner in University of Nottingham, University of London, King's College London, University of Bath, University of Strathclyde, Cardiff University, Queen's University Belfast, Monash University Melbourne and Trinity College Dublin. She is serving as a member of the Irish Medicine Board (2011-2014) and the Pharmaceutical Society of Ireland (2011-2014) and is a member of the College of Medicine and Health Executive UCC and the School of Pharmacy Executive. Professor O'Driscoll was awarded the 'Person of the Year award' for outstanding contribution to science by the Parenteral Drug Association (Ireland Chapter) in 2013 and in 2007/2008 was honoured with the 'Award for Professional Excellence' and 'Award for Pharmacist of the Year' by Helix Health.
Professor O'Driscoll is a Board member of: the Health Products Regulatory Authority (HPRA) (2011-20) Council Member of the Pharmaceutical Society of Ireland (PSI) (2011-15); Cork Cancer Research Centre (CCRC) (2014-17); Critical Path USA (2018-date) and Co-founder and Co-Chair of Regulatory Science Ireland (RSI) (2014-19).
Biography
Caitriona M. O'Driscoll is Professor and Chair of Pharmaceutics in the School of Pharmacy, University College Cork, Ireland.Total Career Publications: 135. Google Scholar H-Index: 48, citations 7214; Scopus H-Index: 43, citations 5486.
Total Career Research Income: Euro 10.5M. PhDs Graduated (Career): 25 PhDs
She received a B.Sc. in Pharmacy from University College Dublin in 1976 and a PhD in 1983 from the University of Dublin, Trinity College. In 1977 she joined the faculty of the School of Pharmacy in Trinity College and held the posts of lecturer (1977-1994) and senior lecturer (1995-2003) in Pharmaceutics during which time she undertook a sabbatical in the Department of Pharmaceutical Chemistry at the University of Kansas. In 2003 she was appointed as Professor of Pharmaceutics at UCC and was, at the same time, appointed as the first Head of the School of Pharmacy at UCC, she served as Head from 2003-09 and 2010-13.During her tenure as Professor of Pharmaceutics she has established an energetic, productive and expanding drug delivery research team. The expertise established spans from pre-formulation through to production and manufacture of prototype delivery systems suitable for clinical trial. The group has obtained funding from exchequer and non-exchequer sources and offers a range of PhD positions. Strong links to the Pharmaceutical Industry underpin many of the research projects. The establishment within UCC of the drug delivery group and the development of interactions with Pharmaceutical Chemistry and Process & Chemical Engineering at UCC gives the University a unique strength which facilitates drug development research from drug design and synthesis all the way through formulation and production to clinical trial.
Professor O'Driscoll has published peer-reviewed research articles in key pharmaceutical journals, including Journal of Controlled Release, Molecular Pharmaceutics, and Pharmaceutical Research. She has been invited to give lectures at various international conferences and institutions worldwide and is a member of the Editorial Advisory Board for several journals including European Journal of Pharmaceutical Sciences, Journal of Pharmaceutical Sciences, Journal of Pharmacy and Pharmacology, Journal of Drug Delivery, Science and Technology and Pharmaceutical Nanotechnology.
Professor O'Driscoll is an external examiner for University of Bath, Masters in Pharmacy and for the Pharmaceutical Society of Ireland, Professional Registration examination. She has acted as PhD thesis examiner in University of Nottingham, University of London, King's College London, University of Bath, University of Strathclyde, Cardiff University, Queen's University Belfast, Monash University Melbourne and Trinity College Dublin. She is serving as a member of the Irish Medicine Board (2011-2014) and the Pharmaceutical Society of Ireland (2011-2014) and is a member of the College of Medicine and Health Executive UCC and the School of Pharmacy Executive. Professor O'Driscoll was awarded the 'Person of the Year award' for outstanding contribution to science by the Parenteral Drug Association (Ireland Chapter) in 2013 and in 2007/2008 was honoured with the 'Award for Professional Excellence' and 'Award for Pharmacist of the Year' by Helix Health.
Professor O'Driscoll is a Board member of: the Health Products Regulatory Authority (HPRA) (2011-20) Council Member of the Pharmaceutical Society of Ireland (PSI) (2011-15); Cork Cancer Research Centre (CCRC) (2014-17); Critical Path USA (2018-date) and Co-founder and Co-Chair of Regulatory Science Ireland (RSI) (2014-19).
Research Interests
Professor O’Driscoll’s research strategy is translational in nature and product driven. The theme of the research is drug delivery with an emphasis on `problem’ or difficult drugs e.g. poorly water soluble compounds, and, products of the pharmaceutical biotechnology industry including peptide/protein type drugs, plasma DNA and siRNA. These candidate drugs are chosen for strategic reasons. Greater than 40% of new chemical entities currently synthesised as potential drugs are poorly water soluble and consequently are difficult to formulate for efficient delivery. In recent years significant growth has occurred in the pharmaceutical biotechnology industry in Ireland and internationally. Biopharmaceuticals, including peptide/proteins, genes and siRNA, are now approaching 50% of all new drugs in development. It is well accepted that the major barrier to marketing these product as novel therapeutics is the design of efficient delivery systems. The focus has been to develop nano-sized delivery constructs which are robust enough to survive processing, are stable on storage and achieve cell /site specific delivery in vivo. Such targeted systems aim to increase therapeutic efficacy and reduce side effects or off target effects. In general the work includes a focus on oral drug delivery, while this is often the most challenging route of administration; it is the most acceptable route for the patient and consequently the most commercially viable.
Research Grants
| Project | Funding Body | Start Date | End Date | Award | |
|---|---|---|---|---|---|
| Formulation development and deposition of novel antibacterial coatings using atomic laser deposition to prevent infections associated with orthopaedic trauma implants. | Science Foundation of Ireland | 01-JAN-13 | 30-JUN-14 | €103,259.00 | |
| Development of Taste masking Platform Technologies | Industry | 01-JAN-90 | 31-MAY-22 | €78,350.00 | |
| Bioavailability Study in Pigs | Industry | 15-APR-05 | 30-SEP-07 | €37,354.00 | |
| EI "A new versatile range of synthetic gene delivery vectors" | Enterprise Irl | 01-JUL-05 | 30-SEP-06 | €30,400.00 | |
| IRCSET PG "Non viral gene delivery" | Irish Research Council for Science, Engineering & Technology (IRCSET) | 01-OCT-05 | 31-MAR-09 | €80,915.00 | |
| Cyclodextrin-derived vectors for RNA interface and gene silencing PC/2006/202 | Enterprise Irl | 04-JUL-06 | 03-NOV-07 | €103,445.00 | |
| Development of Taste Masking Platform Technologies | Enterprise Irl | 10-JUL-06 | 31-MAY-08 | €356,938.00 | |
| SFI ' Modified CD's as novel targeted¿for Cancer Therapy" | Science Foundation of Ireland | 01-SEP-06 | 28-FEB-10 | €141,500.00 | |
| Cancer Research Ireland "Systematic evaluation of the bioavailability and therapeutic efficacy of ." | Miscellaneous Non Exchequer | 01-OCT-06 | 31-MAR-09 | €34,000.00 | |
| IRCSET PG "siRNA delivery in prostrate cancer" | Irish Research Council for Science, Engineering & Technology (IRCSET) | 01-OCT-07 | 30-SEP-10 | €74,586.00 | |
| SFI Oral & Pulmonary deliverary of peptides & genes - Irish Drug Delivery Research Network (IDDN) | Science Foundation of Ireland | 01-DEC-07 | 31-MAY-13 | €1,330,663.00 | |
| IRCSET PG Non Viral Delivery of siRNA - Student Aoife O'Mahony | Irish Research Council for Science, Engineering & Technology (IRCSET) | 01-NOV-08 | 31-OCT-12 | €72,009.00 | |
| EI - Cyclodextrin-derived vectors for RNAi | Enterprise Irl | 01-APR-09 | 01-OCT-11 | €542,188.00 | |
| SFI OIP 2010 Equipment & Staff | Science Foundation of Ireland | 01-JAN-10 | 31-DEC-11 | €28,065.00 | |
| Creating a Lipid Formulation Classification System. | Foreign Research Institute | 01-NOV-10 | 30-SEP-22 | €35,000.00 | |
| Pre-clinical development of stealth cyclodextrin siRNA nano-delivery systems for prostate cancer treatment. | Irish Funded Research Non Exchequer | 01-OCT-11 | 31-DEC-15 | €282,013.00 | |
| New Oral Nanomedicines - Transporting Therapeutic Macromolecules across the Intestinal Barrier. | European Union | 01-MAY-12 | 30-APR-17 | €459,100.00 | |
| The use of non-Viral Vectors to effectively silence Genes in Primary and Metastatic Prostate Cancer Models. | Irish Funded Research Non Exchequer | 01-OCT-12 | 30-SEP-16 | €136,980.00 |
Publications
Peer Reviewed Journals
| Year | Publication | |
|---|---|---|
| (2023) | 'Nano-Hydroxyapatite/PLGA Mixed Scaffolds as a Tool for Drug Development and to Study Metastatic Prostate Cancer in the Bone' Dozzo A;Chullipalliyalil K;McAuliffe M;O'Driscoll CM;Ryan KB; (2023) 'Nano-Hydroxyapatite/PLGA Mixed Scaffolds as a Tool for Drug Development and to Study Metastatic Prostate Cancer in the Bone'. Pharmaceutics, 15 (1) [DOI] [Details] | |
| (2023) | 'Cyclodextrin-Based Nanoparticles for Delivery of Antisense Oligonucleotides Targeting Huntingtin' Mendonça MCP;Sun Y;Cronin MF;Lindsay AJ;Cryan JF;O'Driscoll CM; (2023) 'Cyclodextrin-Based Nanoparticles for Delivery of Antisense Oligonucleotides Targeting Huntingtin'. Pharmaceutics, 15 (2) [DOI] [Details] | |
| (2022) | 'The blood-brain barrier in aging and neurodegeneration' Knox EG;Aburto MR;Clarke G;Cryan JF;O'Driscoll CM; (2022) 'The blood-brain barrier in aging and neurodegeneration'. Molecular Psychiatry, [DOI] [Details] | |
| (2022) | 'Modelling acute myeloid leukemia (AML): What's new? A transition from the classical to the modern' Dozzo A;Galvin A;Shin JW;Scalia S;O'Driscoll CM;Ryan KB; (2022) 'Modelling acute myeloid leukemia (AML): What's new? A transition from the classical to the modern'. Drug Delivery And Translational Research, [DOI] [Details] | |
| (2022) | 'Best practices in current models mimicking drug permeability in the gastrointestinal tract - an UNGAP review' O'Shea JP;Augustijns P;Brandl M;Brayden DJ;Brouwers J;Griffin BT;Holm R;Jacobsen AC;Lennernäs H;Vinarov Z;O'Driscoll CM; (2022) 'Best practices in current models mimicking drug permeability in the gastrointestinal tract - an UNGAP review'. European Journal of Pharmaceutical Sciences, 170 :106098-106133 [DOI] [Details] | |
| (2022) | 'Strategies to Mitigate and Treat Orthopaedic Device-Associated Infections' Kennedy DG;O'Mahony AM;Culligan EP;O'Driscoll CM;Ryan KB; (2022) 'Strategies to Mitigate and Treat Orthopaedic Device-Associated Infections'. Antibiotics-Basel, 11 (12) [DOI] [Details] | |
| (2022) | 'A cyclodextrin-based nanoformulation achieves co-delivery of ginsenoside Rg3 and quercetin for chemo-immunotherapy in colorectal cancer' Sun D.;Zou Y.;Song L.;Han S.;Yang H.;Chu D.;Dai Y.;Ma J.;O'Driscoll C.M.;Yu Z.;Guo J. (2022) 'A cyclodextrin-based nanoformulation achieves co-delivery of ginsenoside Rg3 and quercetin for chemo-immunotherapy in colorectal cancer'. Acta Pharmaceutica Sinica B, 12 (1):378-393 [DOI] [Details] | |
| (2021) | 'Current challenges and future perspectives in oral absorption research: An opinion of the UNGAP network' Vinarov Z;Abrahamsson B;Artursson P;Batchelor H;Berben P;Bernkop-Schnürch A;Butler J;Ceulemans J;Davies N;Dupont D;Flaten GE;Fotaki N;Griffin BT;Jannin V;Keemink J;Kesisoglou F;Koziolek M;Kuentz M;Mackie A;Meléndez-Martínez AJ;McAllister M;Müllertz A;O'Driscoll CM;Parrott N;Paszkowska J;Pavek P;Porter CJH;Reppas C;Stillhart C;Sugano K;Toader E;Valentová K;Vertzoni M;De Wildt SN;Wilson CG;Augustijns P; (2021) 'Current challenges and future perspectives in oral absorption research: An opinion of the UNGAP network'. Advanced Drug Delivery Reviews, 171 [DOI] [Details] | |
| (2021) | 'Predicting budesonide performance in healthy subjects and patients with Crohn's disease using biorelevant in vitro dissolution testing and PBPK modeling' Effinger, A;O ' Driscoll, CM;McAllister, M;Fotaki, N (2021) 'Predicting budesonide performance in healthy subjects and patients with Crohn's disease using biorelevant in vitro dissolution testing and PBPK modeling'. European Journal of Pharmaceutical Sciences, 157 [DOI] [Details] | |
| (2021) | 'Investigating the Impact of Crohn's Disease on the Bioaccessibility of a Lipid-Based Formulation with an In Vitro Dynamic Gastrointestinal Model' Effinger, A;McAllister, M;Tomaszewska, I;O'Driscoll, CM;Taylor, M;Gomersall, S;Heaton, J;Smith, KL;Sarcevica, I;Young, SL;Fotaki, N (2021) 'Investigating the Impact of Crohn's Disease on the Bioaccessibility of a Lipid-Based Formulation with an In Vitro Dynamic Gastrointestinal Model'. Molecular Pharmaceutics, 18 :1530-1543 [DOI] [Details] | |
| (2021) | 'Advances in the Design of (Nano)Formulations for Delivery of Antisense Oligonucleotides and Small Interfering RNA: Focus on the Central Nervous System' Mendonça MCP;Kont A;Aburto MR;Cryan JF;O'Driscoll CM; (2021) 'Advances in the Design of (Nano)Formulations for Delivery of Antisense Oligonucleotides and Small Interfering RNA: Focus on the Central Nervous System'. Molecular Pharmaceutics, 18 (4) [DOI] [Full Text] [Details] | |
| (2021) | 'Nanodelivery of immunogenic cell death-inducers for cancer immunotherapy' Sun D;Zhang J;Wang L;Yu Z;O'Driscoll CM;Guo J; (2021) 'Nanodelivery of immunogenic cell death-inducers for cancer immunotherapy'. Drug Discovery Today, 26 (3) [DOI] [Details] | |
| (2021) | 'Modified cyclodextrin-based nanoparticles mediated delivery of siRNA for huntingtin gene silencing across an in vitro BBB model' Mendonça M.C.P.;Cronin M.F.;Cryan J.F.;O'Driscoll C.M. (2021) 'Modified cyclodextrin-based nanoparticles mediated delivery of siRNA for huntingtin gene silencing across an in vitro BBB model'. European Journal Of Pharmaceutics And Biopharmaceutics, 169 :309-318 [DOI] [Full Text] [Details] | |
| (2021) | 'A folate-targeted PEGylated cyclodextrin-based nanoformulation achieves co-delivery of docetaxel and siRNA for colorectal cancer' Zou, Yifang; Xiao, Fang; Song, Liu; Sun, Bingxue; Sun, Dandan; Chu, Di; Wang, Limei; Han, Shulan; Yu, Zhuo; O'Driscoll, Caitriona M.; Guo, Jianfeng (2021) 'A folate-targeted PEGylated cyclodextrin-based nanoformulation achieves co-delivery of docetaxel and siRNA for colorectal cancer'. International Journal of Pharmaceutics, 606 :1-9 [DOI] [Full Text] [Details] | |
| (2021) | 'Regulation of CEACAM Family Members by IBD-Associated Triggers in Intestinal Epithelial Cells, Their Correlation to Inflammation and Relevance to IBD Pathogenesis' Saiz-Gonzalo, G;Hanrahan, N;Rossini, V;Singh, R;Ahern, M;Kelleher, M;Hill, S;O'Sullivan, R;Fanning, A;Walsh, PTT;Hussey, S;Shanahan, F;Nally, K;O'Driscoll, CMM;Melgar, S (2021) 'Regulation of CEACAM Family Members by IBD-Associated Triggers in Intestinal Epithelial Cells, Their Correlation to Inflammation and Relevance to IBD Pathogenesis'. Frontiers In Immunology, 12 [DOI] [Details] | |
| (2020) | 'Pre-clinical evaluation of a modified cyclodextrin-based nanoparticle for intestinal delivery of Liraglutide' Presas E;Tovar S;Cuñarro J;O'Shea JP;O'Driscoll CM; (2020) 'Pre-clinical evaluation of a modified cyclodextrin-based nanoparticle for intestinal delivery of Liraglutide'. Journal of Pharmaceutical Sciences, [DOI] [Details] | |
| (2020) | 'Gastrointestinal diseases and their impact on drug solubility: Celiac disease' Effinger, Angela; O'Driscoll, Caitriona M.; McAllister, Mark; Fotaki, Nikoletta (2020) 'Gastrointestinal diseases and their impact on drug solubility: Celiac disease'. European Journal of Pharmaceutical Sciences, 152 :1-9 [DOI] [Full Text] [Details] | |
| (2020) | 'Long-term stability of insulin glulisine loaded nanoparticles formulated using an amphiphilic cyclodextrin and designed for intestinal delivery' Presas E;Sultan E;Gervasi V;Crean AM;Werner U;Bazile D;O'Driscoll CM; (2020) 'Long-term stability of insulin glulisine loaded nanoparticles formulated using an amphiphilic cyclodextrin and designed for intestinal delivery'. Drug Development and Industrial Pharmacy, [DOI] [Details] | |
| (2020) | 'A Retrospective Biopharmaceutical Analysis of >800 Approved Oral Drug Products: Are Drug Properties of Solid Dispersions and Lipid-Based Formulations Distinctive?' Bennett-Lenane H.;O'Shea J.P.;O'Driscoll C.M.;Griffin B.T. (2020) 'A Retrospective Biopharmaceutical Analysis of >800 Approved Oral Drug Products: Are Drug Properties of Solid Dispersions and Lipid-Based Formulations Distinctive?'. Journal of Pharmaceutical Sciences, [DOI] [Details] | |
| (2020) | 'Gastrointestinal diseases and their impact on drug solubility: Crohn's disease' Effinger, Angela; O'Driscoll, Caitriona M.; McAllister, Mark; Fotaki, Nikoletta (2020) 'Gastrointestinal diseases and their impact on drug solubility: Crohn's disease'. European Journal of Pharmaceutical Sciences, 152 :1-13 [DOI] [Full Text] [Details] | |
| (2020) | 'Gastrointestinal diseases and their impact on drug solubility: Ulcerative Colitis' Effinger, Angela; O'Driscoll, Caitriona M.; McAllister, Mark; Fotaki, Nikoletta (2020) 'Gastrointestinal diseases and their impact on drug solubility: Ulcerative Colitis'. European Journal of Pharmaceutical Sciences, 152 :1-12 [DOI] [Full Text] [Details] | |
| (2019) | 'Scaffold-Based Delivery of Nucleic Acid Therapeutics for Enhanced Bone and Cartilage Repair' Kelly, Domhnall C.; Raftery, Rosanne M.; Curtin, Caroline M.; O’Driscoll, Caitriona M.; O’Brien, Fergal J. (2019) 'Scaffold-Based Delivery of Nucleic Acid Therapeutics for Enhanced Bone and Cartilage Repair'. Journal Of Orthopaedic Research, 37 (8):1671-1680 [DOI] [Full Text] [Details] | |
| (2019) | 'Self-assembled cationic ß-cyclodextrin nanostructures for siRNA delivery' Singh, Raghvendra Pratap; Hidalgo, Tania; Cazade, Pierre-Andre; Darcy, Raphael; Cronin, Michael; Dorin, Irina; O'Driscoll, Caitriona M.; Thompson, Damien (2019) 'Self-assembled cationic ß-cyclodextrin nanostructures for siRNA delivery'. Molecular Pharmaceutics, [DOI] [Full Text] [Details] | |
| (2019) | 'Food for thought: formulating away the food effect - a PEARRL review' O'Shea JP;Holm R;O'Driscoll CM;Griffin BT; (2019) 'Food for thought: formulating away the food effect - a PEARRL review'. Journal of Pharmacy and Pharmacology, 71 (4) [DOI] [Full Text] [Details] | |
| (2019) | 'Development of anisamide-targeted PEGylated gold nanorods to deliver epirubicin for chemo-photothermal therapy in tumour-bearing mice' Wang, L.; Pei, J.; Cong, Z.; Zou, Y.; Sun, T.; Davitt, F.; Garcia-Gil, A.; Holmes, J. D.; O’Driscoll, C. M.; Rahme, K.; Guo, J. (2019) 'Development of anisamide-targeted PEGylated gold nanorods to deliver epirubicin for chemo-photothermal therapy in tumour-bearing mice'. International Journal of Nanomedicine, 14 :1817-1833 [DOI] [Full Text] [Details] | |
| (2019) | 'Anisamide-targeted PEGylated gold nanoparticles designed to target prostate cancer mediate: Enhanced systemic exposure of siRNA, tumour growth suppression and a synergistic therapeutic response in combination with paclitaxel in mice' Luan, X.; Rahme, K.; Cong, Z.; Wang, L.; Zou, Y.; He, Y.; Yang, H.; Holmes, J. D.; O’Driscoll, C. M.; Guo, J. (2019) 'Anisamide-targeted PEGylated gold nanoparticles designed to target prostate cancer mediate: Enhanced systemic exposure of siRNA, tumour growth suppression and a synergistic therapeutic response in combination with paclitaxel in mice'. European Journal Of Pharmaceutics And Biopharmaceutics, 137 :56-67 [DOI] [Full Text] [Details] | |
| (2018) | 'The potential for clinical translation of antibody-targeted nanoparticles in the treatment of acute myeloid leukaemia' Guo J;Luan X;Cong Z;Sun Y;Wang L;McKenna SL;Cahill MR;O'Driscoll CM; (2018) 'The potential for clinical translation of antibody-targeted nanoparticles in the treatment of acute myeloid leukaemia'. Journal Of Controlled Release, 286 [DOI] [Details] | |
| (2018) | 'Cyclodextrin-siRNA conjugates as versatile gene silencing agents' Malhotra, Meenakshi; Gooding, Matt; Evans, James C.;O'Driscoll, Daniel; Darcy, Raphael; O'Driscoll, Caitriona M. (2018) 'Cyclodextrin-siRNA conjugates as versatile gene silencing agents'. European Journal of Pharmaceutical Sciences, 114 :30-37 [DOI] [Full Text] [Details] | |
| (2017) | 'Targeted drug delivery via folate receptors for the treatment of brain cancer: Can the promise deliver?' Guo J., Schlich M., Cryan JF., O’Driscoll CM (2017) 'Targeted drug delivery via folate receptors for the treatment of brain cancer: Can the promise deliver?'. Journal of Pharmaceutical Science, 106 :3413-3420 [Details] | |
| (2017) | 'Anionic liposomes for small interfering ribonucleic acid (siRNA) delivery to primary neuronal cells: Evaluation of alpha-synuclein knockdown efficacy' Schlich, M;Longhena, F;Faustini, G;O'Driscoll, CM;Sinico, C;Fadda, AM;Bellucci, A;Lai, F (2017) 'Anionic liposomes for small interfering ribonucleic acid (siRNA) delivery to primary neuronal cells: Evaluation of alpha-synuclein knockdown efficacy'. Nano Research, 10 :3496-3508 [DOI] [Details] | |
| (2017) | 'Mesoporous silica based dosage forms improve bioavailability of poorly soluble drugs in pigs: case example fenofibrate' O’Shea J., Nagarsekar K., Wieber A, Witt V., Herbert E., O' Driscoll CM., Saal C, Lubda D., Griffin BT., Dressman JB. (2017) 'Mesoporous silica based dosage forms improve bioavailability of poorly soluble drugs in pigs: case example fenofibrate'. Journal of Pharmacy and Pharmacology, [DOI] [Details] | |
| (2017) | 'Cyclodextrin-siRNA conjugates as versatile gene silencing agents' Malhotra M., Gooding M., Evans JC., O’Driscoll D., Darcy R., O’Driscoll CM. (2017) 'Cyclodextrin-siRNA conjugates as versatile gene silencing agents'. European Journal of Pharmaceutical Science, 114 [Details] | |
| (2017) | 'Anionic liposomes for siRNA delivery to primary neuronal cells: Evaluation of alpha synuclein knockdown efficacy' Schlich M., Longhena F., Faustini G., OʹDriscoll CM., Sinico C, Fadda AM, Arianna Bellucci A, Lai F (2017) 'Anionic liposomes for siRNA delivery to primary neuronal cells: Evaluation of alpha synuclein knockdown efficacy'. Nano Research, [DOI] [Details] | |
| (2017) | 'Antibody-Targeted Cyclodextrin-Based Nanoparticles for siRNA Delivery in the Treatment of Acute Myeloid Leukemia: Physicochemical Characteristics, in Vitro Mechanistic Studies, and ex Vivo Patient Derived Therapeutic Efficacy' Guo J;Russell EG;Darcy R;Cotter TG;McKenna SL;Cahill MR;O'Driscoll CM; (2017) 'Antibody-Targeted Cyclodextrin-Based Nanoparticles for siRNA Delivery in the Treatment of Acute Myeloid Leukemia: Physicochemical Characteristics, in Vitro Mechanistic Studies, and ex Vivo Patient Derived Therapeutic Efficacy'. Molecular Pharmaceutics, 14 (3) [DOI] [Details] | |
| (2017) | 'Gold nanoparticles enlighten the future of cancer theranostics' Guo, JF;Rahme, K;He, Y;Li, LL;Holmes, JD;O'Driscoll, CM (2017) 'Gold nanoparticles enlighten the future of cancer theranostics'. International Journal of Nanomedicine, 12 :6131-6152 [DOI] [Full Text] [Details] | |
| (2017) | 'Folate-targeted amphiphilic cyclodextrin nanoparticles incorporating a fusogenic peptide deliver therapeutic siRNA and inhibit the invasive capacity of 3D prostate cancer tumours' Evans, James C.; Malhotra, Meenakshi; Sweeney, Katrina; Darcy, Raphael; Nelson, Colleen C.; Hollier, Brett G.; O’Driscoll, Caitriona M. (2017) 'Folate-targeted amphiphilic cyclodextrin nanoparticles incorporating a fusogenic peptide deliver therapeutic siRNA and inhibit the invasive capacity of 3D prostate cancer tumours'. International Journal of Pharmaceutics, 532 (1):511-518 [DOI] [Full Text] [Details] | |
| (2017) | 'Formulation and evaluation of anisamide-targeted amphiphilic cyclodextrin nanoparticles to promote therapeutic gene silencing in a 3D prostate cancer bone metastases model' Evans, James C.; Malhotra, Meenakshi; Fitzgerald, Kathleen A.; Guo, Jianfeng; Cronin, Michael F.; Curtin, Caroline M.; O’Brien, Fergal J.; Darcy, Raphael; O’Driscoll, Caitriona M. (2017) 'Formulation and evaluation of anisamide-targeted amphiphilic cyclodextrin nanoparticles to promote therapeutic gene silencing in a 3D prostate cancer bone metastases model'. Molecular Pharmaceutics, 14 (1):42-52 [DOI] [Full Text] [Details] | |
| (2016) | 'Pharmacokinetic, pharmacodynamic and biodistribution following oral administration of nanocarriers containing peptide and protein drugs' Griffin, B. T.,Guo, J.,Presas, E.,Donovan, M. D.,Alonso, M. J.,O'Driscoll, C. M. (2016) 'Pharmacokinetic, pharmacodynamic and biodistribution following oral administration of nanocarriers containing peptide and protein drugs'. Advanced Drug Delivery Reviews, [DOI] [Details] | |
| (2016) | 'A novel, anisamide-targeted cyclodextrin nanoformulation for siRNA delivery to prostate cancer cells expressing the sigma-1 receptor' Fitzgerald, KA;Malhotra, M;Gooding, M;Sallas, F;Evans, JC;Darcy, R;O'Driscoll, CM (2016) 'A novel, anisamide-targeted cyclodextrin nanoformulation for siRNA delivery to prostate cancer cells expressing the sigma-1 receptor'. International Journal of Pharmaceutics, 499 :131-145 [DOI] [Details] | |
| (2016) | 'Folate-targeted amphiphilic cyclodextrin.siRNA nanoparticles for prostate cancer therapy exhibit PSMA mediated uptake, therapeutic gene silencing in vitro and prolonged circulation in vivo' Evans, J. C.,Malhotra, M.,Guo, J.,O'Shea, J. P.,Hanrahan, K.,O'Neill, A.,Landry, W. D.,Griffin, B. T.,Darcy, R.,Watson, R. W.,O'Driscoll, C. M. (2016) 'Folate-targeted amphiphilic cyclodextrin.siRNA nanoparticles for prostate cancer therapy exhibit PSMA mediated uptake, therapeutic gene silencing in vitro and prolonged circulation in vivo'. Nanomedicine, 12 (8):2341-2351 [DOI] [Details] | |
| (2016) | 'Lipid-based nanocarriers for oral peptide delivery' Niu, Z.,Conejos-Sanchez, I.,Griffin, B. T.,O'Driscoll, C. M.,Alonso, M. J. (2016) 'Lipid-based nanocarriers for oral peptide delivery'. Adv Drug Deliv Rev, 106 (Pt B):337-354 [DOI] [Details] | |
| (2016) | 'RNA interference for multiple myeloma therapy: targeting signal transduction pathways' Guo J;McKenna SL;O'Dwyer ME;Cahill MR;O'Driscoll CM; (2016) 'RNA interference for multiple myeloma therapy: targeting signal transduction pathways'. Expert Opinion on Therapeutic Targets, 20 (1) [DOI] [Details] | |
| (2016) | 'Anisamide-targeted gold nanoparticles for siRNA delivery in prostate cancer – synthesis, physicochemical characterisation and in vitro evaluation' Fitzgerald, K. A.; Rahme, K.; Guo, J.; Holmes, J. D.; O’Driscoll, C. M. (2016) 'Anisamide-targeted gold nanoparticles for siRNA delivery in prostate cancer – synthesis, physicochemical characterisation and in vitro evaluation'. Journal of Materials Chemistry B, 4 (13):2242-2252 [DOI] [Full Text] [Details] | |
| (2015) | 'Biomimetic gold nanocomplexes for gene knockdown - will gold deliver dividends for siRNA nanomedicines?' Guo, J.; Rahme, K.; Fitzgerald, K. A.; Holmes, J. D.; O’Driscoll, C. M. (2015) 'Biomimetic gold nanocomplexes for gene knockdown - will gold deliver dividends for siRNA nanomedicines?'. Nano Research, 8 (10):3111-3140 [DOI] [Full Text] [Details] | |
| (2015) | 'Exploring the Impact of Drug Properties on the Extent of Intestinal Lymphatic Transport - In Vitro and In Vivo Studies' Lawless, E.,Griffin, B. T.,O'Mahony, A.,O'Driscoll, C. M. (2015) 'Exploring the Impact of Drug Properties on the Extent of Intestinal Lymphatic Transport - In Vitro and In Vivo Studies'. Pharmaceutical research, 32 (55):1817-1829 [Details] | |
| (2015) | 'Lipidic dispersion to reduce food dependent oral bioavailability of fenofibrate: In vitro, in vivo and in silico assessments' O'Shea, J. P.,Faisal, W.,Ruane-O'Hora, T.,Devine, K. J.,Kostewicz, E. S.,O'Driscoll, C. M.,Griffin, B. T. (2015) 'Lipidic dispersion to reduce food dependent oral bioavailability of fenofibrate: In vitro, in vivo and in silico assessments'. European Journal of Pharmaceutics and Biopharmaceutics, 96 :207-216 [Details] | |
| (2015) | 'Evaluation of the physicochemical properties and the biocompatibility of polyethylene glycol-conjugated gold nanoparticles: A formulation strategy for siRNA delivery' Rahme, K.; Guo, J.; Holmes, J. D.; O’Driscoll, C. M. (2015) 'Evaluation of the physicochemical properties and the biocompatibility of polyethylene glycol-conjugated gold nanoparticles: A formulation strategy for siRNA delivery'. Colloids and Surfaces B-Biointerfaces, 135 :604-612 [DOI] [Full Text] [Details] | |
| (2014) | 'Early-Stage Development of Novel Cyclodextrin-siRNA Nanocomplexes Allows for Successful Postnebulization Transfection of Bronchial Epithelial Cells' Hibbitts, A;O'Mahony, AM;Forde, E;Nolan, L;Ogier, J;Desgranges, S;Darcy, R;MacLoughlin, R;O'Driscoll, CM;Cryan, SA (2014) 'Early-Stage Development of Novel Cyclodextrin-siRNA Nanocomplexes Allows for Successful Postnebulization Transfection of Bronchial Epithelial Cells'. Journal Of Aerosol Medicine And Pulmonary Drug Delivery, 27 :466-477 [Details] | |
| (2014) | 'Biomimetic nanoparticles for siRNA delivery in the treatment of leukaemia' Guo J;Cahill MR;McKenna SL;O'Driscoll CM; (2014) 'Biomimetic nanoparticles for siRNA delivery in the treatment of leukaemia'. Biotechnology Advances, 32 (8) [DOI] [Details] | |
| (2013) | 'Nanostructures of Cationic Amphiphilic Cyclodextrin Complexes with DNA' Villari, V;Mazzaglia, A;Darcy, R;O'Driscoll, CM;Micali, N (2013) 'Nanostructures of Cationic Amphiphilic Cyclodextrin Complexes with DNA'. Biomacromolecules, 14 :811-817 [DOI] [Details] | |
| (2013) | 'Cationic and PEGylated Amphiphilic Cyclodextrins: Co-Formulation Opportunities for Neuronal Sirna Delivery' O'Mahony, AM;Ogier, J;Darcy, R;Cryan, JF;O'Driscoll, CM (2013) 'Cationic and PEGylated Amphiphilic Cyclodextrins: Co-Formulation Opportunities for Neuronal Sirna Delivery'. Plos One, 8 [DOI] [Details] | |
| (2013) | 'A novel lipid-based solid dispersion for enhancing oral bioavailability of Lycopene - In vivo evaluation using a pig model' Faisal, W;Ruane-O'Hora, T;O'Driscoll, CM;Griffin, BT (2013) 'A novel lipid-based solid dispersion for enhancing oral bioavailability of Lycopene - In vivo evaluation using a pig model'. International Journal of Pharmaceutics, 453 :307-314 [DOI] [Details] | |
| (2012) | 'A click chemistry route to 2-functionalised PEGylated and cationic beta-cyclodextrins: co-formulation opportunities for siRNA delivery' O'Mahony, AM;Ogier, J;Desgranges, S;Cryan, JF;Darcy, R;O'Driscoll, CM (2012) 'A click chemistry route to 2-functionalised PEGylated and cationic beta-cyclodextrins: co-formulation opportunities for siRNA delivery'. Organic & Biomolecular Chemistry, 10 :4954-4960 [DOI] [Details] | |
| (2010) | 'Bioavailability of lycopene in the rat: the role of intestinal lymphatic transport' Faisal, W;O'Driscoll, CM;Griffin, BT (2010) 'Bioavailability of lycopene in the rat: the role of intestinal lymphatic transport'. Journal of Pharmacy and Pharmacology, 62 :323-331 [DOI] [Details] | |
| (2016) | 'Pharmacokinetic, Pharmacodynamic and Biodistribution following oral administration of nanocarriers containing peptide and protein drugs' Griffin, B.T>, Guo, J., Presas, E., Donovan, M.D., O'Driscoll, C.M. (2016) 'Pharmacokinetic, Pharmacodynamic and Biodistribution following oral administration of nanocarriers containing peptide and protein drugs'. Advanced Drug Delivery Reviews, [DOI] [Details] | |
| (2016) | 'Bioconjugated gold nanoparticles enhance cellular uptake: A proof of concept study for siRNA delivery in prostate cancer cells' Guo J;O'Driscoll CM;Holmes JD;Rahme K; (2016) 'Bioconjugated gold nanoparticles enhance cellular uptake: A proof of concept study for siRNA delivery in prostate cancer cells'. International Journal of Pharmaceutics, 509 (1-2) [DOI] [Details] | |
| (2016) | 'Anisamide-targeted gold nanoparticles for siRNA delivery in prostate cancer - synthesis, physicochemical characterisation and in vitro evaluation' Fitzgerald, KA;Rahme, K;Guo, JF;Holmes, JD;O'Driscoll, CM (2016) 'Anisamide-targeted gold nanoparticles for siRNA delivery in prostate cancer - synthesis, physicochemical characterisation and in vitro evaluation'. Journal of Materials Chemistry B, 4 :2242-2252 [DOI] [Details] | |
| (2016) | '7-formyl-10-methylisoellipticine, a novel ellipticine derivative, induces mitochondrial reactive oxygen species (ROS) and shows anti-leukaemic activity in mice' Russell, EG;Guo, JF;O'Sullivan, EC;O'Driscoll, CM;McCarthy, FO;Cotter, TG (2016) '7-formyl-10-methylisoellipticine, a novel ellipticine derivative, induces mitochondrial reactive oxygen species (ROS) and shows anti-leukaemic activity in mice'. Investigational new drugs, 34 :15-23 [DOI] [Details] | |
| (2016) | 'Lipid-based nanocarriers for oral peptide delivery' Niu Z;Conejos-Sánchez I;Griffin BT;O'Driscoll CM;Alonso MJ; (2016) 'Lipid-based nanocarriers for oral peptide delivery'. Advanced Drug Delivery Reviews, [DOI] [Details] | |
| (2015) | 'The use of collagen-based scaffolds to simulate prostate cancer bone metastases with potential for evaluating delivery of nanoparticulate gene therapeutics' Fitzgerald, KA;Guo, JF;Tierney, EG;Curtin, CM;Malhotra, M;Darcy, R;O'Brien, FJ;O'Driscoll, CM (2015) 'The use of collagen-based scaffolds to simulate prostate cancer bone metastases with potential for evaluating delivery of nanoparticulate gene therapeutics'. Biomaterials, 66 :53-66 [DOI] [Details] | |
| (2015) | 'Delivering a Disease-Modifying Treatment for Huntington's Disease' Godinho BMDC, Malhotra M, O’Driscoll CM, Cryan JF. (2015) 'Delivering a Disease-Modifying Treatment for Huntington's Disease'. Drug Discovery Today, 20 (1) [DOI] [Details] | |
| (2015) | 'Synthesis and characterization of rabies virus glycoprotein-tagged amphiphilic cyclodextrins for siRNA delivery in human glioblastoma cells: in-vitro analysis' Gooding M*, Malhotra M*, McCarthy DJ, Godinho BMDC, Cryan JF, Darcy R, O’Driscoll CM (2015) 'Synthesis and characterization of rabies virus glycoprotein-tagged amphiphilic cyclodextrins for siRNA delivery in human glioblastoma cells: in-vitro analysis'. European Journal of Pharmaceutical Science, [Details] | |
| (2015) | 'Nanoparticles and the blood-brain barrier: advancing from in-vitro models towards therapeutic significance' Mc Carthy DJ, Malhotra M, O'Mahony AM, Cryan JF, O'Driscoll CM (2015) 'Nanoparticles and the blood-brain barrier: advancing from in-vitro models towards therapeutic significance'. Pharmaceutical research, 32 (4):1161-1185 [DOI] [Details] | |
| (2015) | 'Cyclodextrin mediated delivery of NF-kappa B and SRF siRNA reduces the invasion potential of prostate cancer cells in vitro' Evans, JC;McCarthy, J;Torres-Fuentes, C;Cryan, JF;Ogier, J;Darcy, R;Watson, RW;O'Driscoll, CM (2015) 'Cyclodextrin mediated delivery of NF-kappa B and SRF siRNA reduces the invasion potential of prostate cancer cells in vitro'. Gene Therapy, 22 :802-810 [DOI] [Details] | |
| (2015) | 'Evaluation of the physicochemical properties and the biocompatibility of polyethylene glycol-conjugated gold nanoparticles: A formulation strategy for siRNA delivery' Rahme, K;Guo, JF;Holmes, JD;O'Driscoll, CM (2015) 'Evaluation of the physicochemical properties and the biocompatibility of polyethylene glycol-conjugated gold nanoparticles: A formulation strategy for siRNA delivery'. Colloids and Surfaces B-Biointerfaces, 135 :604-612 [DOI] [Details] | |
| (2015) | 'Lipidic dispersion to reduce food dependent oral bioavailability of fenofibrate: In vitro, in vivo and in silico assessments' O'Shea, JP;Faisal, W;Ruane-O'Hora, T;Devine, KJ;Kostewicz, ES;O'Driscoll, CM;Griffin, BT (2015) 'Lipidic dispersion to reduce food dependent oral bioavailability of fenofibrate: In vitro, in vivo and in silico assessments'. European Journal Of Pharmaceutics And Biopharmaceutics, 96 :207-216 [DOI] [Details] | |
| (2015) | 'Positively charged, surfactant-free gold nanoparticles for nucleic acid delivery' Guo, JF;Armstrong, MJ;O'Driscoll, CM;Holmes, JD;Rahme, K (2015) 'Positively charged, surfactant-free gold nanoparticles for nucleic acid delivery'. RSC Advances, 5 :17862-17871 [DOI] [Details] | |
| (2015) | 'Exploring the Impact of Drug Properties on the Extent of Intestinal Lymphatic Transport - In Vitro and In Vivo Studies' Lawless, E;Griffin, BT;O'Mahony, A;O'Driscoll, CM (2015) 'Exploring the Impact of Drug Properties on the Extent of Intestinal Lymphatic Transport - In Vitro and In Vivo Studies'. Pharmaceutical Research, 32 :1817-1829 [DOI] [Details] | |
| (2015) | 'Synthesis and characterization of rabies virus glycoprotein-tagged amphiphilic cyclodextrins for siRNA delivery in human glioblastoma cells: In vitro analysis' Gooding, M;Malhotra, M;McCarthy, DJ;Godinho, BMDC;Cryan, JF;Darcy, R;O'Driscoll, CM (2015) 'Synthesis and characterization of rabies virus glycoprotein-tagged amphiphilic cyclodextrins for siRNA delivery in human glioblastoma cells: In vitro analysis'. European Journal of Pharmaceutical Sciences, 71 :80-92 [DOI] [Details] | |
| (2015) | 'Positively Charged, Surfactant-Free Gold Nanoparticles for Nucleic Acid Delivery' Rahme K., Guo J., Armstrong M, O’Driscoll CM., Holmes JD (2015) 'Positively Charged, Surfactant-Free Gold Nanoparticles for Nucleic Acid Delivery'. RSC Advances, [Details] | |
| (2015) | 'Lipidic dispersion to reduce food dependent oral bioavailability of fenofibrate: in vitro, in vivo and in silico assessments' O'Shea, J.P.; Faisal, W; Ruane-O’Hora, T; Devine, K.J.; Kostewicz, E.S.; O'Driscoll, C.M.; Griffin, B.T. (2015) 'Lipidic dispersion to reduce food dependent oral bioavailability of fenofibrate: in vitro, in vivo and in silico assessments'. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 96 :207-216 [DOI] [Details] | |
| (2015) | 'RNAi therapeutics for brain cancer: current advancements in RNAi delivery strategies' Malhotra M., Toulouse A., Godhino B.M.D.C., McCarthy D.J., Cryan J.F., O'Driscoll C.M. (2015) 'RNAi therapeutics for brain cancer: current advancements in RNAi delivery strategies'. Molecular Biosystems, 11 :2635-2657 [DOI] [Details] | |
| (2014) | 'Biomimetic nanoparticles for siRNA delivery in the treatment of leukaemia' Guo J, Cahill MR, McKenna SL, O’Driscoll CM. (2014) 'Biomimetic nanoparticles for siRNA delivery in the treatment of leukaemia'. Biotechnology Advances, [DOI] [Details] | |
| (2014) | 'PEGylated cyclodextrins as novel siRNA nanosystems: correlations between polyethylene glycol length and nanoparticle stability' Godinho BM;Ogier JR;Quinlan A;Darcy R;Griffin BT;Cryan JF;O'Driscoll CM; (2014) 'PEGylated cyclodextrins as novel siRNA nanosystems: correlations between polyethylene glycol length and nanoparticle stability'. International Journal of Pharmaceutics, 473 (1-2) [DOI] [Details] | |
| (2014) | 'The Role of Transcription Factors in Prostate Cancer and Potential for Future RNA Interference Therapy' Fitzgerald K, Evans J, McCarthy J, Guo J, Prencipe M, Kearney M, Watson W, Caitriona M O’ Driscoll. (2014) 'The Role of Transcription Factors in Prostate Cancer and Potential for Future RNA Interference Therapy'. Expert Opinion on Therapeutic Targets, 18 (6):1-17 [Details] | |
| (2014) | 'Biophysical and Structural Characterisation of Nucleic Acid Complexes with Modified Cyclodextrins Using Circular Dichroism' O'Mahony, AM,Cronin, MF,Mcmahon, A,Evans, JC,Daly, K,Darcy, R,O'Driscoll, CM (2014) 'Biophysical and Structural Characterisation of Nucleic Acid Complexes with Modified Cyclodextrins Using Circular Dichroism'. Journal of Pharmaceutical Sciences, 103 :1346-1355 [DOI] [Details] | |
| (2014) | 'Exploring the impact of drug properties on the extent of intestinal lymphatic transport - in vitro and in vivo studies' Lawless E., Griffin BT., O’Mahony A., O’Driscoll CM. (2014) 'Exploring the impact of drug properties on the extent of intestinal lymphatic transport - in vitro and in vivo studies'. Pharmaceutical Research, [DOI] [Details] | |
| (2014) | 'Differential nanotoxicological and neuroinflammatory liabilities of non-viral vectors for RNA interference in the central nervous system' Godinho BM, McCarthy DJ, Torres-Fuentes C, Beltrán CJ, McCarthy J, Quinlan A, Ogier JR, Darcy R, O'Driscoll CM, Cryan JF (2014) 'Differential nanotoxicological and neuroinflammatory liabilities of non-viral vectors for RNA interference in the central nervous system'. Biomaterials, 35 (1):489-499 [DOI] [Details] | |
| (2013) | 'PEGylated gold nanoparticles: polymer quantification as a function of PEG lengths and nanoparticle dimensions' Rahme, K.; Hobbs, R. G.; Chen, L.; Morris, M. A.; O’Driscoll, C.; Holmes, J. D. (2013) 'PEGylated gold nanoparticles: polymer quantification as a function of PEG lengths and nanoparticle dimensions'. RSC Advances, 3 (17):6085-6094 [DOI] [Full Text] [Details] | |
| (2013) | 'Non-viral nanosystems for gene and small interfering RNA delivery to the central nervous system: formulating the solution' O'Mahony AM, Godinho BM, Cryan JF, O'Driscoll CM (2013) 'Non-viral nanosystems for gene and small interfering RNA delivery to the central nervous system: formulating the solution'. Journal of pharmaceutical sciences, 102 (10):3469-3484 [DOI] [Details] | |
| (2013) | 'Cationic and PEGylated Amphiphilic Cyclodextrins: Co-Formulation Opportunities for Neuronal Sirna Delivery' O'Mahony AM, Ogier J, Darcy R, Cryan JF, O'Driscoll CM (2013) 'Cationic and PEGylated Amphiphilic Cyclodextrins: Co-Formulation Opportunities for Neuronal Sirna Delivery'. Plos One, 8 (6) [DOI] [Details] | |
| (2013) | 'In vitro investigations of the efficacy of cyclodextrin-siRNA complexes modified with lipid-PEG-Octaarginine: towards a formulation strategy for non-viral neuronal siRNA delivery' O'Mahony AM, Desgranges S, Ogier J, Quinlan A, Devocelle M, Darcy R, Cryan JF, O'Driscoll CM (2013) 'In vitro investigations of the efficacy of cyclodextrin-siRNA complexes modified with lipid-PEG-Octaarginine: towards a formulation strategy for non-viral neuronal siRNA delivery'. Pharmaceutical research, 30 (4):1086-1098 [DOI] [Details] | |
| (2013) | 'Self-assembling modified ß-cyclodextrin nanoparticles as neuronal siRNA delivery vectors: focus on Huntington's disease' Godinho BM, Ogier JR, Darcy R, O'Driscoll CM, Cryan JF (2013) 'Self-assembling modified ß-cyclodextrin nanoparticles as neuronal siRNA delivery vectors: focus on Huntington's disease'. Molecular pharmaceutics, 10 (2):640-649 [DOI] [Details] | |
| (2013) | 'Highly Stable PEGylated Gold Nanoparticles in Water: Applications in Biology and Catalysis' Rahme K., Nolan MT., Doody T., McGlacken GP., Morris MA., O’Driscoll C and Holmes JD. (2013) 'Highly Stable PEGylated Gold Nanoparticles in Water: Applications in Biology and Catalysis'. RSC Advances, 3 :21016-21024 [Details] | |
| (2013) | 'Non-Viral Nanosystems for Gene and siRNA delivery to the Central Nervous System: Formulating the Solution' O’Mahony AM,. Godinho BMDC, Cryan JF and O’Driscoll CM. (2013) 'Non-Viral Nanosystems for Gene and siRNA delivery to the Central Nervous System: Formulating the Solution'. Journal of Pharmaceutical Sciences, 102 :4369-4384 [Details] | |
| (2012) | 'Characterisation of cationic amphiphilic cyclodextrins for neuronal delivery of siRNA: effect of reversing primary and secondary face modifications' O'Mahony AM, Doyle D, Darcy R, Cryan JF, O'Driscoll CM (2012) 'Characterisation of cationic amphiphilic cyclodextrins for neuronal delivery of siRNA: effect of reversing primary and secondary face modifications'. European Journal of Pharmaceutical Sciences, 47 (5):896-903 [DOI] [Details] | |
| (2012) | 'Click-modified cyclodextrins as nonviral vectors for neuronal siRNA delivery' O'Mahony AM, Godinho BM, Ogier J, Devocelle M, Darcy R, Cryan JF, O'Driscoll CM (2012) 'Click-modified cyclodextrins as nonviral vectors for neuronal siRNA delivery'. ACS chemical neuroscience, 3 (10):744-752 [DOI] [Details] | |
| (2012) | 'A click chemistry route to 2-functionalised PEGylated and cationic ß-cyclodextrins: co-formulation opportunities for siRNA delivery' O'Mahony AM, Ogier J, Desgranges S, Cryan JF, Darcy R, O'Driscoll CM (2012) 'A click chemistry route to 2-functionalised PEGylated and cationic ß-cyclodextrins: co-formulation opportunities for siRNA delivery'. Organic & Biomolecular Chemistry, 10 (25):4954-4960 [DOI] [Details] | |
| (1994) | 'The solubility and rate intestinal absorption of DDT in mixed micellar systems' C.M. O'Driscoll, O.G. Obodozie and O.I. Corrigan. (1994) 'The solubility and rate intestinal absorption of DDT in mixed micellar systems'. European Journal of Drug Metabolism and Pharmacokinetics, 3 :74-78 [Details] | |
| (2014) | 'PEGylated cyclodextrins as Novel siRNA nanosystems: correlations between polyethylene glycol length and nanoparticle stability' Godinho BMDC, Ogier JR, Quinlan A, Darcy R, Griffin BT, Cryan JF, O’Driscoll CM. (2014) 'PEGylated cyclodextrins as Novel siRNA nanosystems: correlations between polyethylene glycol length and nanoparticle stability'. International Journal of Pharmaceutics, 473 :105-112 [Details] | |
| (2014) | 'Comparison of in vitro tests at various levels of complexity for the prediction of in vivo performance of lipid-based formulations: case studies with fenofibrate' Griffin BT, Kuentz M, Vertzoni M, Kostewicz ES, Fei Y, Faisal W, Stillhart C, O'Driscoll CM, Reppas C, Dressman JB (2014) 'Comparison of in vitro tests at various levels of complexity for the prediction of in vivo performance of lipid-based formulations: case studies with fenofibrate'. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 86 (3):427-437 [DOI] [Details] | |
| (2014) | 'Early-Stage Development of Novel Cyclodextrin-siRNA Nanocomplexes Allows for Successful Postnebulization Transfection of Bronchial Epithelial Cells' Hibbitts A, O’Mahony AM, Forde E, Nolan L, Ogier J, Desgranges S, Darcy R MacLoughlin R, O’Driscoll CM, Cryan SA. (2014) 'Early-Stage Development of Novel Cyclodextrin-siRNA Nanocomplexes Allows for Successful Postnebulization Transfection of Bronchial Epithelial Cells'. Journal Of Aerosol Medicine And Pulmonary Drug Delivery, :466-477 [DOI] [Details] | |
| (2013) | 'Delivering RNAi therapeutics with non-viral technology: a promising strategy for prostate cancer?' Guo J., Evans J and O’Driscoll CM. (2013) 'Delivering RNAi therapeutics with non-viral technology: a promising strategy for prostate cancer?'. Trends In Molecular Medicine, [Details] | |
| (2013) | 'Nanostructures of cationic amphiphilic cyclodextrin complexes with DNA' Villari, V., Mazzaglia, A., Darcy, R., O'Driscoll, CM and Micali, N. (2013) 'Nanostructures of cationic amphiphilic cyclodextrin complexes with DNA'. Biomacromolecules, 14 (3):811-817 [DOI] [Details] | |
| (2013) | 'Amphiphilic polyallylamine based polymeric micelles for siRNA delivery to the gastrointestinal tract: in vitro investigations' Guo J., O’Mahony AM., Cheng WP and O’Driscoll, CM (2013) 'Amphiphilic polyallylamine based polymeric micelles for siRNA delivery to the gastrointestinal tract: in vitro investigations'. International Journal of Pharmaceutics, 447 (1-2):150-157 [DOI] [Details] | |
| (2013) | 'Cyclodextrins for Non-Viral Gene and siRNA Delivery' O'Mahony AM., O’Neill MJ., Godinho BMDC., Darcy, R., Cryan, JF and; O'Driscoll, CM. (2013) 'Cyclodextrins for Non-Viral Gene and siRNA Delivery'. Pharmaceutical Nanotechnology, 1 :6-14 [Full Text] [Details] | |
| (2013) | 'Self-assembling Modified β-Cyclodextrin Nanoparticles as Neuronal siRNA Delivery Vectors: Focus on Huntington's Disease' Godinho BM, Ogier JR, Darcy R, O'Driscoll CM, Cryan JF. (2013) 'Self-assembling Modified β-Cyclodextrin Nanoparticles as Neuronal siRNA Delivery Vectors: Focus on Huntington's Disease'. Molecular Pharmaceutics, 10 :640-649 [DOI] [Details] | |
| (2013) | 'In Vitro Investigations of the Efficacy of Cyclodextrin-siRNA Complexes Modified with Lipid-PEG-Octaarginine: Towards a Formulation Strategy for Non-viral Neuronal siRNA Delivery' O'Mahony, AM,Desgranges, S,Ogier, J,Quinlan, A,Devocelle, M,Darcy, R,Cryan, JF,O'Driscoll, CM (2013) 'In Vitro Investigations of the Efficacy of Cyclodextrin-siRNA Complexes Modified with Lipid-PEG-Octaarginine: Towards a Formulation Strategy for Non-viral Neuronal siRNA Delivery'. Pharmaceutical Research, 30 :1086-1098 [DOI] [Details] | |
| (2013) | 'Gene silencing of TNF-alpha in a murine model of acute colitis using a modified cyclodextrin delivery system' McCarthy, J,O'Neill, MJ,Bourre, L,Walsh, D,Quinlan, A,Hurley, G,Ogier, J,Shanahan, F,Melgar, S,Darcy, R,O'Driscoll, CM (2013) 'Gene silencing of TNF-alpha in a murine model of acute colitis using a modified cyclodextrin delivery system'. Journal of controlled release : official journal of the Controlled Release Society, 168 :28-34 [DOI] [Details] | |
| (2013) | 'Gastrointestinal gene delivery by cyclodextrins - In vitro quantification of extracellular barriers' O'Neill, MJ,O'Mahony, AM,Byrne, C,Darcy, R,O'Driscoll, CM (2013) 'Gastrointestinal gene delivery by cyclodextrins - In vitro quantification of extracellular barriers'. International Journal of Pharmaceutics, 456 :390-399 [DOI] [Details] | |
| (2012) | 'Pattern Recognition Receptors - Molecular orchestrators of Inflammation in Inflammatory Bowel Disease' Walsh D, McCarthy J, O’ Driscoll CM and Melgar S. (2012) 'Pattern Recognition Receptors - Molecular orchestrators of Inflammation in Inflammatory Bowel Disease'. Cytokine & Growth Factor Reviews, [DOI] [Details] | |
| (2012) | 'Click-modified cyclodextrins as non-viral vectors for neuronal siRNA delivery' O'Mahony, AM, Godinho, BMDC, Ogier, J, Devocelle, M, Darcy, R, Cryan, JF, O'Driscoll, CM (2012) 'Click-modified cyclodextrins as non-viral vectors for neuronal siRNA delivery'. ACS Chemical Neuroscience, 10 (3):744-752 [DOI] [Full Text] [Details] | |
| (2012) | 'Targeted gene delivery to hepatocytes with galactosylated amphiphilic cyclodextrins' McMahon A., O’Neill MJ., Gomez E., Donohue R., Forde D., Darcy R., and O’Driscoll CM. (2012) 'Targeted gene delivery to hepatocytes with galactosylated amphiphilic cyclodextrins'. Journal of Pharmacy and Pharmacology, 54 :1063-1073 [DOI] [Details] | |
| (2012) | 'Characterisation of cationic amphiphilic cyclodextrins for neuronal delivery of siRNA: Effect of reversing primary and secondary face modifications' O'Mahony AM, Doyle D, Darcy R, Cryan JF, O'Driscoll CM. (2012) 'Characterisation of cationic amphiphilic cyclodextrins for neuronal delivery of siRNA: Effect of reversing primary and secondary face modifications'. European Journal of Pharmaceutical Sciences, 47 (5):896-903 [DOI] [Full Text] [Details] | |
| (2012) | 'Anisamide-targeted cyclodextrin nanoparticles for siRNA delivery to prostate tumours in mice' Guo J., Ogier J., Desgranges S., Darcy R., and O’Driscoll CM. (2012) 'Anisamide-targeted cyclodextrin nanoparticles for siRNA delivery to prostate tumours in mice'. Biomaterials, 33 (31):7775-7784 [DOI] [Full Text] [Details] | |
| (2012) | 'Systemic delivery of therapeutic small interfering RNA using a pH-triggered amphiphilic poly-L-lysine nanocarrier to suppress prostate cancer growth in mice' Guo J., Cheng WP., Gu J., Ding C., Qu X., Yang Z., and O’Driscoll CM (2012) 'Systemic delivery of therapeutic small interfering RNA using a pH-triggered amphiphilic poly-L-lysine nanocarrier to suppress prostate cancer growth in mice'. European Journal of Pharmaceutical Sciences, 45 (5):521-532 [DOI] [Full Text] [Details] | |
| (2012) | 'Characterisation of cationic amphiphilic cyclodextrins for neuronal delivery of siRNA: Effect of reversing primary and secondary face modifications' O'Mahony, AM,Doyle, D,Darcy, R,Cryan, JF,O'Driscoll, CM (2012) 'Characterisation of cationic amphiphilic cyclodextrins for neuronal delivery of siRNA: Effect of reversing primary and secondary face modifications'. European Journal of Pharmaceutical Sciences, 47 :896-903 [DOI] [Details] | |
| (2011) | 'Intestinal delivery of non-viral gene therapeutics: physiological barriers and preclinical models' O’Neill JM, Bourre L, Melgar S, O’Driscoll CM. (2011) 'Intestinal delivery of non-viral gene therapeutics: physiological barriers and preclinical models'. Drug Discovery Today, :203-218 [DOI] [Details] | |
| (2011) | 'Mechanistic studies on the uptake and intracellular trafficking of novel cyclodextrin transfection complexes by intestinal epithelial cells' Martin J. O¿ Neill, Jianfeng Guo, Colin Byrne, Raphael Darcy and Caitriona M. O¿ Driscoll; (2011) 'Mechanistic studies on the uptake and intracellular trafficking of novel cyclodextrin transfection complexes by intestinal epithelial cells'. International Journal of Pharmaceutics, 413 (1-2):174-183 [DOI] [Full Text] [Details] | |
| (2011) | 'Intestinal Delivery of Non-viral Gene Therapeutics- Physiological Barriers & Pre-clinical Models' Martin J. O'Neill, Ludovic Bourre, Silvia Melgar, and Caitriona M. O'Driscoll.; (2011) 'Intestinal Delivery of Non-viral Gene Therapeutics- Physiological Barriers & Pre-clinical Models'. Drug Discovery Today, 16 (5/6):203-218 [DOI] [Details] | |
| (2011) | 'Opportunities and challenges for oral delivery of hydrophobic versus hydrophilic peptide and protein-like drugs using lipid-based technologies' Griffin BT, O'Driscoll CM (2011) 'Opportunities and challenges for oral delivery of hydrophobic versus hydrophilic peptide and protein-like drugs using lipid-based technologies'. Therapeutic Delivery, 2 (12):1633-1653 [Details] | |
| (2011) | 'Can non-viral technologies knockdown the barriers to siRNA delivery and achieve the next generation of cancer therapeutics?' Jianfeng Guo, Ludovic Bourre, Declan M. Soden, Gerald C. O'Sullivan, Caitriona O'Driscoll; (2011) 'Can non-viral technologies knockdown the barriers to siRNA delivery and achieve the next generation of cancer therapeutics?'. Biotechnology Advances, 29 (4):402-417 [DOI] [Full Text] [Details] | |
| (2010) | 'Therapeutic targeting in the silent era: advances in non-viral siRNA delivery' Guo, J; Fisher, KA; Darcy, R; Cryan, JF; O'Driscoll, C; (2010) 'Therapeutic targeting in the silent era: advances in non-viral siRNA delivery'. Molecular Biosystems, 6 (7):1143-1161 [DOI] [Full Text] [Details] | |
| (2010) | 'Bioavailability of lycopene in the rat: the role of intestinal lymphatic transport' Faisal, W; O'Driscoll, CM; Griffin, BT; (2010) 'Bioavailability of lycopene in the rat: the role of intestinal lymphatic transport'. Journal of Pharmacy and Pharmacology, 62 (3):323-331 [DOI] [Details] | |
| (2008) | 'Biopharmaceutical challenges associated with drugs with low aqueous solubility - the potential impact of lipid-based formulations' O’Driscoll CM and Griffin BT (2008) 'Biopharmaceutical challenges associated with drugs with low aqueous solubility - the potential impact of lipid-based formulations'. Advanced Drug Delivery Reviews, :617-624 [DOI] [Details] | |
| (2008) | 'Comparison of drug transporter gene expression and functionality in Caco-2 cells from 10 different laboratories' Hayeshi R, Hilgendorf C, Artursson P, Augustijns P, Brodin B, Dehertogh P, Fisher K, Fossati L, Hovenkamp E, Korjamo T, Masungi C, Maubon N, Mols R, Müllertz A, Mönkkönen J, O'Driscoll C, Oppers-Tiemissen HM, Ragnarsson EG, Rooseboom M, Ungell AL.; (2008) 'Comparison of drug transporter gene expression and functionality in Caco-2 cells from 10 different laboratories'. European Journal of Pharmaceutical Sciences, 35 (5):383-396 [Details] | |
| (2008) | 'Cyclodextrin Gene Vectors: Cell Trafficking and The Influence of Lipophilic Chain Length' McMahon, A, Gomez, E, Donohue, R, Forde, D, Darcy, R, O'Driscoll, CM; (2008) 'Cyclodextrin Gene Vectors: Cell Trafficking and The Influence of Lipophilic Chain Length'. Journal of Drug Delivery Science and Technology, 18 (5):303-307 [Details] | |
| (2008) | 'An Examination of the Effect of Intestinal First Pass Extraction on Intestinal Lymphatic Transport of Saquinavir in the Rat' Griffin, B.T. and O’Driscoll, C.M.; (2008) 'An Examination of the Effect of Intestinal First Pass Extraction on Intestinal Lymphatic Transport of Saquinavir in the Rat'. Pharmaceutical Research, 25 (5):1125-1133 [DOI] [Details] | |
| (2006) | 'A comparison of intestinal lymphatic transport and systemic bioavailability of saquinavir from three lipid-based formulations in the anaesthetised rat model' Griffin BT, O'Driscoll CM; (2006) 'A comparison of intestinal lymphatic transport and systemic bioavailability of saquinavir from three lipid-based formulations in the anaesthetised rat model'. Journal of Pharmacy and Pharmacology, 58 (7):917-925 [DOI] [Details] | |
| (2006) | 'Evaluation of Cellular Uptake and Gene Transfer Efficiency of Pegylated Poly-L-Lysine Compacted Dna: Implications For Cancer Gene Therapy' Walsh, M, Tangney, M, O'Neill, MJ, Larkin, JO, Soden, DM, McKenna, SL, Darcy, R, O'Sullivan, GC, O'Driscoll, CM; (2006) 'Evaluation of Cellular Uptake and Gene Transfer Efficiency of Pegylated Poly-L-Lysine Compacted Dna: Implications For Cancer Gene Therapy'. Molecular Pharmaceutics, 3 (6):644-653 [DOI] [Details] | |
| (2005) | 'Quantitative estimation of the effects of bile salt surfactant systems on insulin stability and permeability in the rat intestine using a mass balance model' Lane ME, O'driscoll CM, Corrigan OI; (2005) 'Quantitative estimation of the effects of bile salt surfactant systems on insulin stability and permeability in the rat intestine using a mass balance model'. Journal of Pharmacy and Pharmacology, 57 (2):169-175 [Details] | |
| (2004) | 'Cationic cyclodextrin amphiphiles as gene delivery vectors' Cryan S.A., Donohue R., Ravoo B.J., Darcy R., O'Driscoll C.M.; (2004) 'Cationic cyclodextrin amphiphiles as gene delivery vectors'. Journal of Drug Delivery Science and Technology, 14 (1):57-62 [Details] | |
| (2004) | 'Cell transfection with polycationic cyclodextrin vectors' Cryan S.A., Holohan A., Donohue R., Darcy R., O'Driscoll C.M.; (2004) 'Cell transfection with polycationic cyclodextrin vectors'. European Journal of Pharmaceutical Science, 21 (*):625-633 [Details] | |
| (2004) | 'Stimulation of triglyceride rich lipoprotein secretion by polysorbate 80: in vtiro and in vivo correlation using Caco-2 cells and a cannulated rat intestinal lymphatic model' Seeballuck F., Lawless E., Ashford M.B., O'Driscoll C.M.; (2004) 'Stimulation of triglyceride rich lipoprotein secretion by polysorbate 80: in vtiro and in vivo correlation using Caco-2 cells and a cannulated rat intestinal lymphatic model'. Pharmaceutical Research, 21 (12):2320-2326 [Details] | |
| (2003) | 'The effects of casein on diclofenac release from hydroxypropylmethylcellulose (HPMC) compacts' Gubinns R.H., O'Driscoll C.M., Corrigan O.I.; (2003) 'The effects of casein on diclofenac release from hydroxypropylmethylcellulose (HPMC) compacts'. International Journal of Pharmaceutics, 260 (1):69-76 [Details] | |
| (2003) | 'Intestinal lymphatic targeting of drugs' O'Driscoll C.M.; (2003) 'Intestinal lymphatic targeting of drugs'. STP Pharma Sciences, 13 (1):17-25 [Details] | |
| (2003) | 'The effects of pluronic block copolymers and Cremophor EL on intestinal lipoprotein processing and the potential link with P-glycoprotein in Caco-2 cells' Seeballuck F., Asford M.B., O'Driscoll C.M.; (2003) 'The effects of pluronic block copolymers and Cremophor EL on intestinal lipoprotein processing and the potential link with P-glycoprotein in Caco-2 cells'. Pharmaceutical Research, 20 (7):1085-1092 [Details] | |
| (2003) | 'Estimation of absorption parameters from the non-steady-state phase in the rat gut perfusion model' Corrigan O.I., Gubbins R.H., O'Driscoll C.M.; (2003) 'Estimation of absorption parameters from the non-steady-state phase in the rat gut perfusion model'. Journal of Pharmacy and Pharmacology, 55 (4):487-493 [Details] | |
| (2003) | 'Mechanistic studies on nonviral gene delivery to the intestine using in vitro differentiated cell cuture models and in vivo rat intestinal loop' Cryan S.A., O'Driscoll C.M.; (2003) 'Mechanistic studies on nonviral gene delivery to the intestine using in vitro differentiated cell cuture models and in vivo rat intestinal loop'. Pharmaceutical Research, 20 (4):569-575 [Details] | |
| (2002) | 'Lipid-based formulations for intestinal lymphatic delivery' O'Driscoll CM; (2002) 'Lipid-based formulations for intestinal lymphatic delivery'. European Journal of Pharmaceutical Sciences, 15 (5):405-415 [Details] | |
| (2000) | 'A comparison of the permeation enhancement potential of simple bile salt and mixed bile salt:fatty acid micellar systems using the CaCo-2 cell culture model' Meaney CM, O'Driscoll CM; (2000) 'A comparison of the permeation enhancement potential of simple bile salt and mixed bile salt:fatty acid micellar systems using the CaCo-2 cell culture model'. International Journal of Pharmaceutics, 207 ((1-2)):21-30 [Details] | |
| (1999) | 'Mucus as a barrier to the permeability of hydrophilic and lipophilic compounds in the absence and presence of sodium taurocholate micellar systems using cell culture models' Meaney C, O'Driscoll C; (1999) 'Mucus as a barrier to the permeability of hydrophilic and lipophilic compounds in the absence and presence of sodium taurocholate micellar systems using cell culture models'. European Journal of Pharmaceutical Sciences, 8 (3):167-175 [Details] | |
| (1996) | 'The relationship between rat intestinal permeability and hydrophilic probe size' Lane ME, O'Driscoll CM, Corrigan OI; (1996) 'The relationship between rat intestinal permeability and hydrophilic probe size'. Pharmaceutical Research, 13 (10):1554-1558 [Details] | |
| (1994) | 'The effect of mixed micellar systems, bile salt/fatty acids, on the solubility and intestinal absorption of clofazimine (B663) in the anaesthetised rat' Joan R. O'Reilly, Owen I. Corrigan and Caitriona M. O'Driscoll; (1994) 'The effect of mixed micellar systems, bile salt/fatty acids, on the solubility and intestinal absorption of clofazimine (B663) in the anaesthetised rat'. International Journal of Pharmaceutics, 109 (2):147-154 [Details] | |
| (1994) | 'The effect of simple micellar systems on the solubility and intestinal absorption of clofazimine (B663) in the anaesthetised rat' Joan R. O'Reilly, Owen I. Corrigan and Caitriona M. O'Driscoll; (1994) 'The effect of simple micellar systems on the solubility and intestinal absorption of clofazimine (B663) in the anaesthetised rat'. International Journal of Pharmaceutics, 105 (2):137-146 [Details] | |
| (1991) | 'Blood and lymph transport of DDT after oral and parenteral administration to anaesthetised rats' Caitriona M. O'Driscoll Robert A. Myers and Valentino J. Stella; (1991) 'Blood and lymph transport of DDT after oral and parenteral administration to anaesthetised rats'. International Journal of Pharmaceutics, 73 (2):177-183 [Details] | |
| (1991) | 'A comparison of the effect of synthetic and naturally occurring surfactants on the solubility and absorption of clofazimine (B 663)' O'Driscoll CM, O'Reilly JR, Corrigan OI; (1991) 'A comparison of the effect of synthetic and naturally occurring surfactants on the solubility and absorption of clofazimine (B 663)'. European Journal of Drug Metabolism and Pharmacokinetics, :116-119 [Details] | |
| (1983) | 'The influence of perfusion rate on salicylate absorption in the rat' O'Driscoll KM, Corrigan OI.; (1983) 'The influence of perfusion rate on salicylate absorption in the rat'. Journal of Pharmacy and Pharmacology, 35 (12):814-815 [Details] | |
| (1982) | 'Chlorothiazide-Polyvinylpyrrolidone (PVP) Interactions: Influence on Membrane Permeation (Everted Rat Intestine) and Dissolution' O'Driscoll KM, Corrigan OI.; (1982) 'Chlorothiazide-Polyvinylpyrrolidone (PVP) Interactions: Influence on Membrane Permeation (Everted Rat Intestine) and Dissolution'. Drug Development and Industrial Pharmacy, 8 (4):547-564 [Details] | |
| (1980) | 'The effect of dosage on the bioavailability of chlorothiazide administered in solution' Corrigan OI, O'Driscoll KM.; (1980) 'The effect of dosage on the bioavailability of chlorothiazide administered in solution'. Journal of Pharmacy and Pharmacology, 32 (8):547-549 [Details] |
Conference Publications
| Year | Publication | |
|---|---|---|
| (2011) | 38th Annual Meeting of Controlled Release Society F. F. Farag, M. I. Amaro, A.M. Healy, C. M. O¿Driscoll, A. M. Crean; (2011) Stability of Salmon Calcitonin-Sugar Nanoporous Microparticles 38th Annual Meeting of Controlled Release Society National Harbor, Maryland, U.S.A, [Details] | |
| (2010) | American Association of Pharmaceutical Scientists (AAPS) Annual Conference O'Mahony, AM; Ogier, J; O'Neill, M; Darcy, R; Cryan, JF; O'Driscoll, CM; (2010) Cyclodextrin-based vectors for siRNA delivery: Effects of pegylation on physical and biological properties in vitro American Association of Pharmaceutical Scientists (AAPS) Annual Conference [Details] | |
| (2010) | All-Ireland School of Pharmacy Conference. Queens University, Belfast O'Mahony, A; Ogier, J; Doyle, D; Darcy, R; Cryan, JF; O'Driscoll, CM; (2010) Modified cyclodextrins as siRNA delivery vectors for neuronal and non-neuronal cells: A study of different structural modifications All-Ireland School of Pharmacy Conference. Queens University, Belfast [Details] | |
| (2010) | Annual Meeting of American Society of Gene and Cell Therapy Guo, Jianfeng; Thompson, Colin J; Ping Cheng, Woei; O'Driscoll, Catriona; (2010) Novel comb shaped amphiphilic polyallylamine for potential oral delivery of siRNA to gastrointestinal cancers: physicochemical characterization and in vitro evaluation Annual Meeting of American Society of Gene and Cell Therapy [Details] | |
| (2010) | Neuroscience Ireland Annual Conference 2010 Godinho, BMDC; O'Mahony, AM; Ogier, JR; Darcy, R; O'Driscoll, CM; Cryan, JF; (2010) Cyclodextrins as nonviral-vectors for siRNA delivery to the central nervous system Neuroscience Ireland Annual Conference 2010 [Details] | |
| (2010) | AAPS National Biotechnology Conference Farag, F.F., O'Driscoll, C.M., Crean, A.M.; (2010) Formulation and storage conditions affecting the conformation and degradation of salmon calcitonin delivery systems AAPS National Biotechnology Conference San Francisco, [Details] | |
| (2009) | International Society for Cell and Gene Therapy of Cancer Guo J, Cheng WP, Qu X, Gu J, Ding C, Yang Z, O'Driscoll CM; (2009) pH-triggered amphiphilic poly-L-lysone micelles for passive targetd delivery of siRNA to cancer cells: physicochemical characterisations and in vitro evaluations International Society for Cell and Gene Therapy of Cancer [Details] | |
| (2009) | American Association of Pharmaceutical Scientists (AAPS) Annual Conference Martin O¿ Neill, Colin Byrne , Raphael Darcy , and Caitriona O¿ Driscoll.; (2009) Mechanistic Studies Investigating Binding and Uptake of Amphiphilic Cyclodextrin.DNA Nanoparticles by Caco-2 cells American Association of Pharmaceutical Scientists (AAPS) Annual Conference [Details] | |
| (2009) | Molecules to Medicine Research Conference Martin O¿ Neill, Colin Byrne , Raphael Darcy , and Caitriona O¿ Driscoll.; (2009) Cyclodextrin Mediated Gene Delivery to the Intestine ¿ Predicting Cellular Uptake Pathways and Transfection Complex Stability Molecules to Medicine Research Conference [Details] | |
| (2008) | XVIth Annual Congress of the European Society of Gene and Cell Therapy J.Guo, J. Ogier, R.Darcy and C.M.O¿Driscoll; (2008) Synthesis of Anisic-targeted cyclodextrin for siRNA delivery to cancer cells XVIth Annual Congress of the European Society of Gene and Cell Therapy Brugge, Belgium, [Details] | |
| (2008) | Irish Society for Gene & Cell Therapy Conference J Guo, K Fisher, M. O¿Neill, R. Darcy and C. M. O¿Driscoll; (2008) Investigation of novel anisamide-targeted stealth cyclodextrin nanoparticles for siRNA delivery in prostate cancer Irish Society for Gene & Cell Therapy Conference Cork, Ireland, [Details] | |
| (2008) | British Society for Gene Therapy 5th Annual Conference K.A.Fisher, F.Sallas, R.Darcy and C.M.O'Driscoll; (2008) Characterisation of Folate and Guanidino Modified Cyclodextrins as Non-viral Vectors for siRNA Delivery to Tumour Cells British Society for Gene Therapy 5th Annual Conference Edniburgh, [Details] | |
| (2008) | 30th All Ireland Schools of Pharmacy Research Seminar K.A.Fisher, F.Sallas, R.Darcy and C.M.O'Driscoll; (2008) Folate and Guanidino Modified Cyclodextrins as Non-viral Vectors for siRNA Delivery 30th All Ireland Schools of Pharmacy Research Seminar University College Cork, [Details] | |
| (2008) | Irish Society for Gene and Cell Therapy Conference O¿ Neill M, Walsh M, Byrne C, Darcy R, O¿ Driscoll CM; (2008) Investigating barriers to cyclodextrin mediated gene delivery to the intestine Irish Society for Gene and Cell Therapy Conference [Details] | |
| (2008) | Unknown O'Driscoll, CM ; (2008) Delivery of siRNA: challenges and opportunities Unknown [Details] | |
| (2008) | CRS Annual Meeting O¿ Neill M, Walsh M, Byrne C, Darcy R, O¿ Driscoll CM; (2008) The Effect of Simulated Intestinal Fluid on the Stability and Efficacy of a Novel Cyclodextrin Gene Delivery Vector CRS Annual Meeting New York, USA, [Details] | |
| (2008) | American Association of Pharmaceutical Scientists (AAPS) Faisal, W., O'Driscoll, C.M., Griffin, B.T.; (2008) Solubility and Stability of lycopene in lipid based formulations American Association of Pharmaceutical Scientists (AAPS) [Details] | |
| (2008) | UK & Ireland Controlled Release Society (UKICRS) Faisal, W., O'Driscoll, C.M., Griffin, B.T.; (2008) Investigation of Lycopene absorption mechanisms from the Gastro-intestinal tract of the rat UK & Ireland Controlled Release Society (UKICRS) [Details] | |
| (2007) | XV Annual Congress of the European Society of Gene and Cell Therapy K.A.Fisher, C.Noone, F.Sallas, R.Darcy and C.M.O'Driscoll; (2007) Modified cyclodextrins as novel targeted formulations to deliver siRNA XV Annual Congress of the European Society of Gene and Cell Therapy Rotternam, Holland, [Details] | |
| (2007) | Formulation and characterisation of a novel cyclodextrin gene delivery vector O¿ Neill M, Walsh M, Byrne C, Darcy R, and O¿ Driscoll CM; (2007) Abstract at the American Society of Gene Therapy Formulation and characterisation of a novel cyclodextrin gene delivery vector Seattle, USA, [Details] | |
| (2007) | All Ireland School of Pharmacy Conference Faisal W, O'Driscoll CM, Griffin BT; (2007) Comparison of the intestinal lymphatic transport of lycopene in anaesthetised rat from a range of lipid based formulations All Ireland School of Pharmacy Conference Dublin, Ireland, [Details] | |
| (2007) | XVth Annual Congress of the European Society of Gene and Cell Therapy M. O'Neill, J. Guo, K. Fisher, M. Walsh, C. Byrne, R. Darcy, C.M. O¿Driscoll; (2007) Amphiphilic Cationic Cyclodextrins as Non-Viral Vectors for Gene and siRNA Delivery XVth Annual Congress of the European Society of Gene and Cell Therapy Rotternam, Holland, [Details] | |
| (2007) | Excipient Fest Ireland Faisal W, O'Driscoll CM, Griffin BT; (2007) Comparison of the intestinal lymphatic transport of lycopene in anaesthetised rat Excipient Fest Ireland Cork, Ireland, , 19-JUN-07 - 20-JUN-07 [Details] | |
| (2007) | American Society of Gene Therapy O¿ Neill M, Walsh M, Byrne C, Darcy R, and O¿ Driscoll CM; (2007) Formulation and characterisation of a novel cyclodextrin gene delivery vector American Society of Gene Therapy [Details] | |
| (2007) | Unknown O¿Driscoll CM.; (2007) Current / future prospects of in-vitro/in-vivo correlations for lipid formulations Unknown , pp.25-29 [Details] | |
| (2006) | UK and Ireland Controlled Release Society Meeting, Astrazeneca R & D O¿Neill MJ, Walsh M. Byrne CP, Darcy R and O¿Driscoll CM; (2006) Characterisation of novel amphiphilic polycationic cyclodextrins as non-viral vehicles for gene delivery UK and Ireland Controlled Release Society Meeting, Astrazeneca R & D Loughburough, U.K, [Details] | |
| (2005) | Annual CRS meeting Walsh M, O¿Sullivan G, O¿Driscoll CM; (2005) Characterisation of a poly-L-lysine based non-viral gene therapy system Annual CRS meeting Miami, USA, [Details] | |
| (2005) | 3rd World Conference on Drug Absorption, Transport and Delivery (EUFEPS) Walsh M, Frkanec L, Hammond L, Darcy R, O¿Sullivan G, O¿Driscoll CM; (2005) An amphiphilic polycationic cyclodextrin transfects post-mitotic intestinal cells 3rd World Conference on Drug Absorption, Transport and Delivery (EUFEPS) Barcelona, Spain, [Details] | |
| (2004) | Amer Assoc Pharm Sci., (AAPS) Annual meeting Lawless E and O¿Driscoll CM; (2004) Effect of cyclosporine dose on intestinal lymphatic triglyceride output and lymphatic transport in the mesenteric lymph duct cannulated rat model Amer Assoc Pharm Sci., (AAPS) Annual meeting Baltimore, USA, [Details] | |
| (2004) | Amer Assoc Pharm Sci., (AAPS) Annual meeting Griffin BT, Lawless E and O¿Driscoll CM; (2004) Comparision of the degree of lymphatic transport of a range of lipophilic compounds in the presence of an oleic acid based microemulsion Amer Assoc Pharm Sci., (AAPS) Annual meeting Baltimore, USA, [Details] | |
| (2003) | Amer Assoc Pharm Sci., Annual meeting McMahon, A, Donohue R, Forde D, Darcy R, O¿Driscoll CM; (2003) Hyrophobicity and ligand linker-length affect transfection efficiency of targeted amphiphilic cyclodextrins as gene delivery vectors Amer Assoc Pharm Sci., Annual meeting Salt Lake City, USA, [Details] | |
| (2003) | Amer Assoc Pharm Sci., (AAPS) Annual meeting Lawless E, Seeballuck F, O¿Driscoll CM; (2003) Secretion of intestinal triglyceride in response to lipid-based formulations ¿ A comparison of in vitro Caco-2 and in vivo rat intestinal lymphatic data Amer Assoc Pharm Sci., (AAPS) Annual meeting Salt Lake City, USA, [Details] | |
| (2003) | Annual CRS meeting McMahon, A, Donohue R, Forde D, Darcy R, O¿Driscoll CM; (2003) The role of helper lipid DOPE in novel cyclodextrin/DNA constructs for hepatic-targeted gene delivery Annual CRS meeting Glasgow, UK, [Details] |
Book Chapters
| Year | Publication | |
|---|---|---|
| (2008) | 'Models of the small intestine' Brendan Griffin and Caitriona O'Driscoll; (2008) 'Models of the small intestine' In: Drug absorption studies - in situ, in vitro, and in silico models. New York: Springer. [Details] | |
| (1996) | 'Carbenoxolone Sodium' Pindado, O.I., Corrigan O.I, O'Driscoll C.M.; (1996) 'Carbenoxolone Sodium' In: Analytical Profiles of Drug Substances and Excipients. [Details] | |
| (1992) | 'Anatomy/Physiology of the Lymph' O'Driscoll C.M.; (1992) 'Anatomy/Physiology of the Lymph' In: Lymphatic Transport of Drugs. [Details] | |
| (1992) | 'Clofazimine' O'Driscoll C.M. and Corrigan O.I.; (1992) 'Clofazimine' In: Analytical Profiles of Drug Substances and Excipients. [Details] |
Professional Activities
Honours and Awards
| Year | Title | Awarding Body | |
|---|---|---|---|
| 2013 | Parenteral Drug Association 'Person of the Year' award | Parenteral Drug Association (Ireland Chapter) | |
| 2007 | Helix Health Pharmacist Award for Professional Excellence. | unknown | |
| 2007 | Helix Health Pharmacist Award of Pharmacist of the Year. | unknown |
Professional Associations
| Association | Function | From / To | |
|---|---|---|---|
| Health Products Regulatory Authority | Board Member | 01-JAN-11 / 30-JUN-15 | |
| Pharmaceutical Society of Ireland | Member | 01-JAN-11 / 30-JUN-15 | |
| Controlled Release Society | * | 01-MAY-03 / 02-APR-10 | |
| American Association of Pharmaceutical Scientists | * | 30-DEC-99 / 01-OCT-13 |
Committees
| Committee | Function | From / To | |
|---|---|---|---|
| National Forum for Pharmacy Education and Accreditation | Member of forum | 2011 / 2013 | |
| Pharmaceutical Sciences World Congress for European and African Region - Amsterdam 2007 | Publicity Committee | 2004 / 1899 | |
| 2nd International Symposium on Science and Regulatory Aspects of Dissolution and Bioequivalence - Athens June 05 | Science Planning Committee | 2004 / 1899 | |
| European Drug Absorption Network (EDAN) | Member of Organising Committee | 2008 / 2015 | |
| Poisons Council | Unknown | 2000 / | |
| Pharmaceutical Society of Ireland | Adjudicating Committee | 1998 / 2001 | |
| Pharmaceutical Society of Ireland | Council Member | 1994 / 1997 |
Employment
| Employer | Position | From / To | |
|---|---|---|---|
| UCC | Professor of Pharmaceutics | 01-JUL-03 / 30-DEC-99 | |
| TCD | Senior Lecturer in Pharmaceutics | 01-APR-95 / 30-JUN-03 | |
| University of Kansas, USA | Research Sabbatical | 01-JAN-88 / 31-DEC-88 | |
| TCD | Lecturer in Pharmaceutics | 01-SEP-77 / 01-JUL-95 |
Education
| Year | Institution | Qualification | Subject | |
|---|---|---|---|---|
| 1983 | University of Dublin, Trinity College | PhD | ||
| 1981 | University of Dublin, Trinity College | MA (Jure officii) | ||
| 1976 | University College Dublin | BSc Pharm |
Journal Activities
| Journal | Role | To / From | |
|---|---|---|---|
| Journal Of Drug Delivery Science And Technology | Member of Editorial Board | 01-JAN-02 - | |
| Journal Of Pharmacy And Pharmacology | Editor | 01-JAN-00 - | |
| Journal Of Pharmaceutical Sciences | Member of Editorial Board | 01-JAN-03 - | |
| European Journal Of Pharmaceutical Science | Member of Editorial Board | 01-JAN-03 - | |
| Biopharmaceutics And Drug Disposition | Member of Editorial Board | 01-JAN-03 - | |
| Pharmaceutical Research | Referee | - | |
| European Journal Of Pharmaceutical Science | Referee | - | |
| Journal Of Drug Delivery Science And Technology | Referee | - | |
| International Journal Of Pharmaceutics | Referee | - |
Teaching Activities
Teaching Interests
Teaching Interests:
Prof. O'Driscoll currently teaches various aspects of Pharmaceutics to all levels of under-graduate B. Pharmacy students including PF1012, PF3008, PF4109.
At postgraduate level she teaches modules in the MSc Biotechnology and MSc Pharmaceutical Technology and Quality Systems