Research Profile

Harriet Bennett-Lenane

Biography

Dr. Harriet Bennett-Lenane is currently a lecturer in Clinical Pharmaceutics at the School of Pharmacy in University College Cork. She received a Bachelor of Science (Pharmacy) (BSc.(Pharm)) degree from Trinity College Dublin in 2017 and a Master of Pharmacy (MPharm) from the Royal College of Surgeons in Ireland (RCSI) in 2018. Before completing a PhD in Pharmaceutics in University College Cork in 2022 as part of an Irish Research Council Postgraduate Scholarship. The focus of her PhD thesis was computational pharmaceutics approaches to support drug developability. She has previous pharmaceutical industry experience working across Quality Assurance and Regulatory Affairs roles. 


Research Interests

  • Machine Learning-Informed Medicines Optimisation.
  • Computational Pharmaceutics-Informed Drug Delivery.
  • Digitalisation of Pharmacy Practice.  
  • Delivery of Community Pharmacy Services to Vulnerable Patient Groups.
  • Career Pathways and Motivators of Pharmacy Students and Graduates.

Publications

Peer Reviewed Journals

 YearPublication
(2023)'Advancing Algorithmic Drug Product Development: Recommendations for Machine Learning Approaches in Drug Formulation'
Murray JD;Lange JJ;Bennett-Lenane H;Holm R;Kuentz M;O'Dwyer PJ;Griffin BT; (2023) 'Advancing Algorithmic Drug Product Development: Recommendations for Machine Learning Approaches in Drug Formulation'. European Journal of Pharmaceutical Sciences, [DOI] [Details]
(2021)'In Silico, In Vitro, and In Vivo Evaluation of Precipitation Inhibitors in Supersaturated Lipid-Based Formulations of Venetoclax'
Koehl NJ;Henze LJ;Bennett-Lenane H;Faisal W;Price DJ;Holm R;Kuentz M;Griffin BT; (2021) 'In Silico, In Vitro, and In Vivo Evaluation of Precipitation Inhibitors in Supersaturated Lipid-Based Formulations of Venetoclax'. Molecular Pharmaceutics, 18 (6) [DOI] [Full Text] [Details]
(2021)'Characterization of gastrointestinal transit and luminal conditions in pigs using a telemetric motility capsule'
Henze, Laura J.; Koehl, Niklas J.; Bennett-Lenane, Harriet; Holm, René; Grimm, Michael; Schneider, Felix; Weitschies, Werner; Koziolek, Mirko; Griffin, Brendan T. (2021) 'Characterization of gastrointestinal transit and luminal conditions in pigs using a telemetric motility capsule'. European Journal of Pharmaceutical Sciences, 156 [DOI] [Full Text] [Details]
(2021)'Artificial neural networks to predict the apparent degree of supersaturation in supersaturated lipid-based formulations: A pilot study'
Bennett-Lenane, Harriet; O'Shea, Joseph P.; Murray, Jack D.; Ilie, Alexandra-Roxana; Holm, René; Kuentz, Martin; Griffin, Brendan T. (2021) 'Artificial neural networks to predict the apparent degree of supersaturation in supersaturated lipid-based formulations: A pilot study'. Pharmaceutics, 13 (9):1-14 [DOI] [Full Text] [Details]
(2021)'Exploring porcine gastric and intestinal fluids using microscopic and solubility estimates: Impact of placebo self-emulsifying drug delivery system administration to inform bio-predictive in vitro tools'
Bennett-Lenane, Harriet; Jørgensen, Jacob R.; Koehl, Niklas J.; Henze, Laura J.; O'Shea, Joseph P.; Müllertz, Anette; Griffin, Brendan T. (2021) 'Exploring porcine gastric and intestinal fluids using microscopic and solubility estimates: Impact of placebo self-emulsifying drug delivery system administration to inform bio-predictive in vitro tools'. European Journal of Pharmaceutical Sciences, 161 [DOI] [Full Text] [Details]
(2021)'Machine learning methods for prediction of food effects on bioavailability: A comparison of support vector machines and artificial neural networks'
Bennett-Lenane, Harriet; Griffin, Brendan T.; O'Shea, Joseph P. (2021) 'Machine learning methods for prediction of food effects on bioavailability: A comparison of support vector machines and artificial neural networks'. European Journal of Pharmaceutical Sciences, [DOI] [Full Text] [Details]
(2020)'Novel Biphasic Lipolysis Method To Predict in Vivo Performance of Lipid-Based Formulations'
O'Dwyer PJ;Box KJ;Koehl NJ;Bennett-Lenane H;Reppas C;Holm R;Kuentz M;Griffin BT; (2020) 'Novel Biphasic Lipolysis Method To Predict in Vivo Performance of Lipid-Based Formulations'. Molecular Pharmaceutics, [DOI] [Full Text] [Details]
(2020)'A retrospective biopharmaceutical analysis of >800 approved oral drug products: Are drug properties of solid dispersions and lipid-based formulations distinctive?'
Bennett-Lenane, Harriet;O'Shea, Joseph P.;O'Driscoll, Caitriona M.;Griffin, Brendan T. (2020) 'A retrospective biopharmaceutical analysis of >800 approved oral drug products: Are drug properties of solid dispersions and lipid-based formulations distinctive?'. Journal of Pharmaceutical Sciences, [DOI] [Full Text] [Details]
(2020)'Applying computational predictions of biorelevant solubility ratio upon self-emulsifying lipid-based formulations dispersion to predict dose number'
Bennett-Lenane, Harriet; Koehl, Niklas J.; O'Dwyer, Patrick J.; Box, Karl J.; O'Shea, Joseph P.; Griffin, Brendan T. (2020) 'Applying computational predictions of biorelevant solubility ratio upon self-emulsifying lipid-based formulations dispersion to predict dose number'. Journal of Pharmaceutical Sciences, [DOI] [Full Text] [Details]

Professional Activities

Honours and Awards

 YearTitleAwarding Body
2018Irish Research Council Postgraduate Scholarship Irish Research Council
2017Gold Medal for Pharmaceutics Trinity College Dublin
2017Gold Medal Trinity College Dublin
2014Entrance Exhibition Scholar Trinity College Dublin

Professional Associations

 AssociationFunctionFrom / To
Pharmaceutical Society of Ireland Member/

Employment

 EmployerPositionFrom / To
Eli Lilly and Company Senior Associate - CMC Development Regulatory/
University College Cork PhD Scholar/
MSD Human Health Ireland Regulatory Affairs Specialist/
University College Cork Undergraduate Laboratory Demonstrator/
Clinigen Ireland Ltd. Quality Assurance Specialist/

Education

 YearInstitutionQualificationSubject
2017Trinity College Dublin B.Sc(Pharm)Pharmacy
2022University College Cork PhDPharmaceutics
2018Royal College of Surgeons in Ireland MPharmMPharm

Teaching Activities

Teaching Interests

Clinical Pharmacy and Pharmaceutics with a focus on integrated, research-led and active learning approaches. 

Contact details

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School of Pharmacy

Cógaisíocht

Cavanagh Pharmacy Building Room UG06 University College Cork

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