Research Profile

Linda O'Keeffe

Biography

I am a Senior Research Fellow in Epidemiology and I currently hold a Health Research Board (HRB) Emerging Investigator Award (EIA) 2019-2023 [EIA-FA-2019-007 SCaRLeT] at University College Cork. Prior to this, I was recipient of a prestigious UK Medical Research Council (MRC) Fellowship [MR/M014509/1] where I trained in life course and causal inference epidemiology at the University of Bristol from 2014-2019. I completed my PhD research in perinatal and life course epidemiology as a HRB Structured Population and Health-services Research Education (SPHeRE) Scholar from 2010-2014.


Research Grants

 ProjectFunding
Body
Start DateEnd DateAward
Sex Differences in Cardiovascular Risk Accross Lifecourse Transitions.Health Research Board01-AUG-1931-JUL-23€699,546.00
Understanding gender differences in cardiometabolic risk across the life courseMedical Research Council01-AUG-1501-AUG-19€442,976.00
Evidence for Policies to Prevent Chronic Conditions (EPICC)Health Research Board01-MAY-20€250,000.00

Contract Researchers

 Researcher NameProjectRoleFunding Body
Kate O'NeillSex Differences in Cardiovascular Risk Across Life course Transitions (SCaRLeT)Senior Postdoctoral ResearcherHealth Research Board

Publications

Peer Reviewed Journals

 YearPublication
(2020)'Age at period cessation and trajectories of cardiovascular risk factors across mid and later life'
O'Keeffe L.M.;Kuh D.;Fraser A.;Howe L.D.;Lawlor D.;Hardy R. (2020) 'Age at period cessation and trajectories of cardiovascular risk factors across mid and later life'. Heart, [DOI] [Details]
(2020)'Preventive health counselling during antenatal care using the pregnancy risk assessment monitoring system (PRAMS) in Ireland'
Murphy M.;McHugh S.;O'Keeffe L.;Greene R.;Corcoran P.;Kearney P. (2020) 'Preventive health counselling during antenatal care using the pregnancy risk assessment monitoring system (PRAMS) in Ireland'. BMC pregnancy and childbirth, 20 (1) [DOI] [Details]
(2019)'Epigenetic gestational age and trajectories of weight and height during childhood: a prospective cohort study'
Bright HD;Howe LD;Khouja JN;Simpkin AJ;Suderman M;O'Keeffe LM; (2019) 'Epigenetic gestational age and trajectories of weight and height during childhood: a prospective cohort study'. Clinical Epigenetics, 11 (1) [DOI] [Details]
(2019)'Data on trajectories of measures of cardiovascular health in the Avon Longitudinal Study of Parents and Children (ALSPAC)'
O'Keeffe LM;Simpkin AJ;Tilling K;Anderson EL;Hughes AD;Lawlor DA;Fraser A;Howe LD; (2019) 'Data on trajectories of measures of cardiovascular health in the Avon Longitudinal Study of Parents and Children (ALSPAC)'. Data In Brief, 23 [DOI] [Details]
(2018)'Smoking as a risk factor for lung cancer in women and men: a systematic review and meta-analysis'
O'Keeffe LM;Taylor G;Huxley RR;Mitchell P;Woodward M;Peters SAE; (2018) 'Smoking as a risk factor for lung cancer in women and men: a systematic review and meta-analysis'. Bmj Open, 8 (10) [DOI] [Details]
(2018)'Associations of Y chromosomal haplogroups with cardiometabolic risk factors and subclinical vascular measures in males during childhood and adolescence'
O'Keeffe LM;Howe LD;Fraser A;Hughes AD;Wade KH;Anderson EL;Lawlor DA;Erzurumluoglu AM;Davey-Smith G;Rodriguez S;Stergiakouli E; (2018) 'Associations of Y chromosomal haplogroups with cardiometabolic risk factors and subclinical vascular measures in males during childhood and adolescence'. Atherosclerosis, 274 [DOI] [Details]
(2018)'Sex-specific trajectories of measures of cardiovascular health during childhood and adolescence: A prospective cohort study'
O'Keeffe LM;Simpkin AJ;Tilling K;Anderson EL;Hughes AD;Lawlor DA;Fraser A;Howe LD; (2018) 'Sex-specific trajectories of measures of cardiovascular health during childhood and adolescence: A prospective cohort study'. Atherosclerosis, 278 [DOI] [Details]
(2018)'Associations of Body Mass and Fat Indexes With Cardiometabolic Traits'
Bell JA;Carslake D;O'Keeffe LM;Frysz M;Howe LD;Hamer M;Wade KH;Timpson NJ;Davey Smith G; (2018) 'Associations of Body Mass and Fat Indexes With Cardiometabolic Traits'. Journal of The American College of Cardiology, 72 (24) [DOI] [Details]
(2018)'Epigenetic gestational age acceleration: a prospective cohort study investigating associations with familial, sociodemographic and birth characteristics'
Khouja JN;Simpkin AJ;O'Keeffe LM;Wade KH;Houtepen LC;Relton CL;Suderman M;Howe LD; (2018) 'Epigenetic gestational age acceleration: a prospective cohort study investigating associations with familial, sociodemographic and birth characteristics'. Clinical Epigenetics, 10 [DOI] [Details]
(2018)'Mid- and Long-Term Health Risks in Living Kidney Donors: A Systematic Review and Meta-analysis'
O'Keeffe LM;Ramond A;Oliver-Williams C;Willeit P;Paige E;Trotter P;Evans J;Wadström J;Nicholson M;Collett D;Di Angelantonio E; (2018) 'Mid- and Long-Term Health Risks in Living Kidney Donors: A Systematic Review and Meta-analysis'. Annals of Internal Medicine, 168 (4) [DOI] [Details]
(2018)'Environmental toxic metal contaminants and risk of cardiovascular disease: systematic review and meta-analysis'
Chowdhury R;Ramond A;O'Keeffe LM;Shahzad S;Kunutsor SK;Muka T;Gregson J;Willeit P;Warnakula S;Khan H;Chowdhury S;Gobin R;Franco OH;Di Angelantonio E; (2018) 'Environmental toxic metal contaminants and risk of cardiovascular disease: systematic review and meta-analysis'. BMJ (Clinical Research Ed.), 362 [DOI] [Details]
(2016)'Body-mass index and all-cause mortality: individual-participant-data meta-analysis of 239 prospective studies in four continents'
Global BMI Mortality Collaboration ;Di Angelantonio E;Bhupathiraju ShN;Wormser D;Gao P;Kaptoge S;Berrington de Gonzalez A;Cairns BJ;Huxley R;Jackson ChL;Joshy G;Lewington S;Manson JE;Murphy N;Patel AV;Samet JM;Woodward M;Zheng W;Zhou M;Bansal N;Barricarte A;Carter B;Cerhan JR;Smith GD;Fang X;Franco OH;Green J;Halsey J;Hildebrand JS;Jung KJ;Korda RJ;McLerran DF;Moore SC;O'Keeffe LM;Paige E;Ramond A;Reeves GK;Rolland B;Sacerdote C;Sattar N;Sofianopoulou E;Stevens J;Thun M;Ueshima H;Yang L;Yun YD;Willeit P;Banks E;Beral V;Chen Zh;Gapstur SM;Gunter MJ;Hartge P;Jee SH;Lam TH;Peto R;Potter JD;Willett WC;Thompson SG;Danesh J;Hu FB; (2016) 'Body-mass index and all-cause mortality: individual-participant-data meta-analysis of 239 prospective studies in four continents'. The Lancet, 388 (10046) [DOI] [Details]
(2016)'Positive lifestyle changes around the time of pregnancy: a cross-sectional study'
O'Keeffe, Linda M; Dahly, Darren L.; Murphy, Marion; Greene, Richard A.; Harrington, Janas M.; Corcoran, Paul; Kearney, Patricia M. (2016) 'Positive lifestyle changes around the time of pregnancy: a cross-sectional study'. Bmj Open, 6 [DOI] [Full Text] [Details]
(2015)'The impact of obstetric mode of delivery on childhood behavior'
O'Keeffe LM, Henriksen TB, Kenny LC, Cryan JF, Khashan AS, Khalaf SY, O'Neill SM (2015) 'The impact of obstetric mode of delivery on childhood behavior'. Social psychiatry and psychiatric epidemiology, [DOI] [Details]
(2015)'Association of Cardiometabolic Multimorbidity With Mortality'
;Di Angelantonio E;Kaptoge S;Wormser D;Willeit P;Butterworth AS;Bansal N;O'Keeffe LM;Gao P;Wood AM;Burgess S;Freitag DF;Pennells L;Peters SA;Hart CL;Håheim LL;Gillum RF;Nordestgaard BG;Psaty BM;Yeap BB;Knuiman MW;Nietert PJ;Kauhanen J;Salonen JT;Kuller LH;Simons LA;van der Schouw YT;Barrett-Connor E;Selmer R;Crespo CJ;Rodriguez B;Verschuren WM;Salomaa V;Svärdsudd K;van der Harst P;Björkelund C;Wilhelmsen L;Wallace RB;Brenner H;Amouyel P;Barr EL;Iso H;Onat A;Trevisan M;D'Agostino RB;Cooper C;Kavousi M;Welin L;Roussel R;Hu FB;Sato S;Davidson KW;Howard BV;Leening MJ;Leening M;Rosengren A;Dörr M;Deeg DJ;Kiechl S;Stehouwer CD;Nissinen A;Giampaoli S;Donfrancesco C;Kromhout D;Price JF;Peters A;Meade TW;Casiglia E;Lawlor DA;Gallacher J;Nagel D;Franco OH;Assmann G;Dagenais GR;Jukema JW;Sundström J;Woodward M;Brunner EJ;Khaw KT;Wareham NJ;Whitsel EA;Njølstad I;Hedblad B;Wassertheil-Smoller S;Engström G;Rosamond WD;Selvin E;Sattar N;Thompson SG;Danesh J; (2015) 'Association of Cardiometabolic Multimorbidity With Mortality'. Jama-Journal Of The American Medical Association, 314 (1) [DOI] [Details]
(2015)'Maternal alcohol use during pregnancy and offspring trajectories of height and weight: A prospective cohort study'
O'Keeffe, LM;Kearney, PM;Greene, RA;Zuccolo, L;Tilling, K;Lawlor, DA;Howe, LD (2015) 'Maternal alcohol use during pregnancy and offspring trajectories of height and weight: A prospective cohort study'. Drug and alcohol dependence, 153 :323-329 [DOI] [Details]
(2015)'Prevalence and predictors of alcohol use during pregnancy: findings from international multicentre cohort studies'
O'Keeffe, LM;Kearney, PM;McCarthy, FP;Khashan, AS;Greene, RA;North, RA;Poston, L;McCowan, LME;Baker, PN;Dekker, GA;Walker, JJ;Taylor, R;Kenny, LC (2015) 'Prevalence and predictors of alcohol use during pregnancy: findings from international multicentre cohort studies'. Bmj Open, 5 [DOI] [Details]
(2014)'Pregnancy Risk Assessment Monitoring System in Ireland: Methods and Response Rates'
O'Keeffe LM, Kearney PM, Greene RA (2014) 'Pregnancy Risk Assessment Monitoring System in Ireland: Methods and Response Rates'. Maternal and child health journal, [DOI] [Details]
(2014)'The effect of moderate gestational alcohol consumption during pregnancy on speech and language outcomes in children: a systematic review'
O'Keeffe LM, Greene RA, Kearney PM (2014) 'The effect of moderate gestational alcohol consumption during pregnancy on speech and language outcomes in children: a systematic review'. Systematic reviews, 3 [DOI] [Full Text] [Details]
(2013)'Surveillance during pregnancy: methods and response rates from a hospital based pilot study of the Pregnancy Risk Assessment Monitoring System in Ireland'
O'Keeffe, LM;Kearney, PM;Greene, RA (2013) 'Surveillance during pregnancy: methods and response rates from a hospital based pilot study of the Pregnancy Risk Assessment Monitoring System in Ireland'. BMC pregnancy and childbirth, 13 [DOI] [Details]
(2013)'Association Between Maternal Alcohol Consumption in Early Pregnancy and Pregnancy Outcomes'
McCarthy, FP;O'Keeffe, LM;Khashan, AS;North, RA;Poston, L;McCowan, LME;Baker, PN;Dekker, GA;Roberts, CT;Walker, JJ;Kenny, LC (2013) 'Association Between Maternal Alcohol Consumption in Early Pregnancy and Pregnancy Outcomes'. Obstetrics and Gynecology, 122 :830-837 [DOI] [Details]

Professional Activities

Conference Contributions

 YearPublication
(2014)UK Society for Social Medicine Annual Meeting,
MC HUGH, S., O’KEEFFE, L., CORCORAN, P., GREENE, R. & KEARNEY, P (2014) Late initiation of antenatal care in a large urban hospital: data from the Pregnancy Risk Assessment Monitoring Syste. [Oral Presentation], UK Society for Social Medicine Annual Meeting, Oxford, United Kingdom . [Details]
(2011)UCC College of Medicine & Health Annual Research Conference,
O'Keeffe L, Lutomski JE, Van Lente E, Kearney P, Greene RA; (2011) Today's babies are Ireland's future: A population-based surveillance system of maternal experiences and behaviours before, during and after pregnancy. [Poster Presentation], UCC College of Medicine & Health Annual Research Conference, Brookfield Health Sciences Complex, College Road, UCC, Cork , 22-JUN-11 - 22-JUN-11. [Details]

Teaching Activities

Recent Postgraduates

 Graduation YearStudent NameInstitutionDegree TypeThesis Title
2019Lisa Ryan NUI (UCC)Puberty timing and cardiovascular risk during adolescence

Contact details

  • Linda O'Keeffe
    Senior Research Fellow
  • linda.okeeffe@ucc.ie
  • Western Gateway Building
    Western Road
    University College Cork

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University College Cork

Coláiste na hOllscoile Corcaigh

College Road, Cork T12 K8AF

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