Research Profile

Anna Golubeva

Biography

Research Interests

I am working on the cutting edge topic of complex interactions between intestinal microbiome and host physiology and behaviour.

My research is focused on:

- exploring the role of microbiota in the regulation of appetite; screening pro- and prebiotics for prevention and controlling overweight and obesity.

- investigation the adverse effects of early-life stress experience to the mental and physiological functioning of the affected offspring; and implication of gut microbiome in these changes.

Publications

Peer Reviewed Journals

 YearPublication
(2015)'Prenatal stress-induced alterations in major physiological systems correlate with gut microbiota composition in adulthood'
Golubeva AV, Crampton S, Desbonnet L, Edge D, O'Sullivan O, Lomasney KW, Zhdanov AV, Crispie F, Moloney RD, Borre YE, Cotter PD, Hyland NP, O'Halloran KD, Dinan TG, O'Keeffe GW, Cryan JF (2015) 'Prenatal stress-induced alterations in major physiological systems correlate with gut microbiota composition in adulthood'. Psychoneuroendocrinology, [DOI] [Details]
(2015)'Differential contribution of key metabolic substrates and cellular oxygen in HIF signalling'
Zhdanov AV, Waters AHC, Golubeva AV, Papkovsky DB (2015) 'Differential contribution of key metabolic substrates and cellular oxygen in HIF signalling'. Experimental Cell Research, [DOI] [Details]
(2015)'Negative allosteric modulation of the mGlu7 receptor reduces visceral hypersensitivity in a stress-sensitive rat strain'
Moloney RD, Golubeva AV, O'Connor RM, Kalinichev M, Dinan TG, Cryan JF (2015) 'Negative allosteric modulation of the mGlu7 receptor reduces visceral hypersensitivity in a stress-sensitive rat strain'. Neurobiology of Stress, [DOI] [Details]
(2015)'Metabotropic glutamate receptors in central nervous system diseases'
Golubeva AV, Moloney RD, O’Connor RM, Dinan TG, Cryan JF (2015) 'Metabotropic glutamate receptors in central nervous system diseases'. Current drug targets,   [Details]
(2015)'Imaging of oxygen gradients in giant umbrella cells: an ex vivo PLIM study'
Zhdanov AV, Golubeva AV, Okkelman IA, Cryan JF, Papkovsky D (2015) 'Imaging of oxygen gradients in giant umbrella cells: an ex vivo PLIM study'. American Journal of Physiology - Cell Physiology, [DOI] [Details]
(2015)'GABAB receptors in the bladder and bowel: Therapeutic potential for positive allosteric modulators? : Commentary on Kalinichev et al., Br J Pharmacol 171: 995–1006'
Hyland NP and Golubeva AV (2015) 'GABAB receptors in the bladder and bowel: Therapeutic potential for positive allosteric modulators? : Commentary on Kalinichev et al., Br J Pharmacol 171: 995–1006'. British Journal of Pharmacology, [DOI] [Details]
(2014)'Availability of the key metabolic substrates dictates the respiratory response of cancer cells to the mitochondrial uncoupling'
Zhdanov AV, Waters AHC, Golubeva AV, Dmitriev RI, Papkovsky DB (2014) 'Availability of the key metabolic substrates dictates the respiratory response of cancer cells to the mitochondrial uncoupling'. Biochimica Et Biophysica Acta-Bioenergetics, [DOI] [Details]
(2014)'The mouse cyclophosphamide model of bladder pain syndrome: tissue characterization, immune profiling and relationship to metabotropic glutamate receptors'
Golubeva AV, Zhdanov AV, Mallel G, Dinan TG, Cryan JF (2014) 'The mouse cyclophosphamide model of bladder pain syndrome: tissue characterization, immune profiling and relationship to metabotropic glutamate receptors'. Physiological reports, [DOI] [Details]
(2014)'Toll-like receptor 4 regulates chronic stress-induced visceral pain in mice'
Tramullas M, Finger BC, Moloney RD, Golubeva AV, Dinan TG, Cryan JF (2014) 'Toll-like receptor 4 regulates chronic stress-induced visceral pain in mice'. Biological Psychiatry, [DOI] [Details]
(2013)'The orthosteric GABAA receptor ligand Thio‐4‐PIOL displays distinctly different functional properties at synaptic and extrasynaptic receptors'
Hoestgaard‐Jensen K, O'Connor RM, Dalby NO, Simonsen Ch, Finger BC, Golubeva AV, Hammer H, Bergmann ML, Kristiansen U, Krogsgaard‐Larsen P, Bräuner‐Osborne H, Ebert B, Frølund B, Cryan JF, Jensen AA (2013) 'The orthosteric GABAA receptor ligand Thio‐4‐PIOL displays distinctly different functional properties at synaptic and extrasynaptic receptors'. British Journal of Pharmacology, [DOI] [Details]
(2013)'Chronic hypoxia leads to a glycolytic phenotype and suppressed HIF-2 signaling in PC12 cells'
Zhdanov AV, Dmitriev RI, Golubeva AV, Gavrilova SA, Papkovsky DB (2013) 'Chronic hypoxia leads to a glycolytic phenotype and suppressed HIF-2 signaling in PC12 cells'. Biochimica Et Biophysica Acta-General Subjects, [DOI] [Details]
(2007)'Protective effect of lornoxicam on development of myocardial infarction in rats under conditions of ischemia and ischemia-reperfusion'
Gavrilova SA, Lipina TV, Zagidullin TR, Fominykh ES, Golubeva AV, Varenik EN, Parnes Ela, Semenov PA (2007) 'Protective effect of lornoxicam on development of myocardial infarction in rats under conditions of ischemia and ischemia-reperfusion'. Kardiologiia, [Details]
(2006)'Protective effect of peptide semax (ACTH (4-7) Pro-Gly-Pro) on the rat heart late after myocardial infarction'
Gavrilova SA, Golubeva AV, Lipina TV, Fominykh ES, Shornikova MV, Postnikov AB, Andrejeva LA, Chentsov IuS, Koshelev VB (2006) 'Protective effect of peptide semax (ACTH (4-7) Pro-Gly-Pro) on the rat heart late after myocardial infarction'. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova / Rossiiskaia akademiia nauk, [Details]
(2006)'Protective effect of peptide semax on the rat heart in acute myocardial infarction'
Golubeva AV, Gavrilova SA, Lipina TV, Shornikova MV, Postnikov AB, Andreeva LA, Chentsov IuS, Koshelev VB (2006) 'Protective effect of peptide semax on the rat heart in acute myocardial infarction'. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova / Rossiiskaia akademiia nauk, [Details]

Conference Publications

 YearPublication
(2015)XIX International Congress of Polish Pharmacological Society
Golubeva AV, Moloney RD, Dinan TG, Cryan JF (2015) Group III mGlu receptors in the brain and periphery: Implications for visceral pain XIX International Congress of Polish Pharmacological Society [Details]
(2014)Junior Scientists ECNP Workshop on Neuropsychopharmacology 2014, Nice, France
Golubeva AV, Crampton SJ, Desbonnet L, Edge D, Lomasney KW, Hyland NP, O'Halloran KD, Dinan TG, O'Keeffe GW, Cryan JF (2014) P.4.011 Differential negative impact of prenatal stress on physiological systems in adulthood Junior Scientists ECNP Workshop on Neuropsychopharmacology 2014, Nice, France [DOI] [Details]

Professional Activities

Honours and Awards

 YearTitleAwarding Body
2015IBRO International Travel Grant International Brain Research Organization
2014GENIEUR travel award COST Action GENIEUR
2014ECNP travel award European College of Neuropsychopharmacology

Professional Associations

 AssociationFunctionFrom / To
American Physiological Society Regular Membership08-OCT-15 / 31-DEC-16
Neuroscience Ireland Society Regular Membership01-SEP-13 / 31-DEC-14
Society for Experimental Biology and Medicine Regular Membership01-JUN-08 / 31-DEC-10

Employment

 EmployerPositionFrom / To
APC Microbiome Institute, University College Cork, Ireland Postdoctoral researcher01-FEB-12 / 31-OCT-15
Thomson Reuters, Moscow office, Russia Annotator of publications01-MAR-10 / 31-MAR-11
Moscow State University, Moscow, Russia Assistant lecturer01-MAR-08 / 30-JUN-11

Education

 YearInstitutionQualificationSubject
2008Moscow State University, Moscow, Russia Ph.D.Physiology
2004Moscow State University, Moscow, Russia M.Sc. (with distinction)Physiology
2002Moscow State University, Moscow, Russia B.Sc.Physiology

Languages

 LanguageReadingWritingSpeaking
Russian FluentFluentFluent
English FluentFluentFluent
German BasicBasicBasic

Other Activities

 Description

2015 - present Review editor in Frontiers in Gastrointestinal Pharmacology
2012 - present Regular reviewer for British Journal of Pharmacology, Neuropharmacology, Neurobiology of Stress, Journal of Visualized Experiments
egular reviewer for British Journal of Pharmacology, Neuropharmacology, Neurobiology of Stress, Journal of Visualized Experiments

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