Research Profile

Pauline Scanlan

Biography

Pauline Scanlan graduated in 2002 with a B.Sc. in Plant and Microbiology Biotechnology (1H) from University College Cork (UCC). She continued her education at UCC and graduated with a Ph.D. in Medicine in 2007; this included a one-year Marie Curie studentship at Wageningen University, The Netherlands. Shortly afterwards she moved to the Department of Zoology at the University of Oxford, U.K. as a postdoctoral researcher in the lab of Prof. Angus Buckling. Dr Scanlan returned to Ireland in 2012 and following a short postdoctoral research position at UCC she moved to Teagasc, Moorepark after successfully securing a Marie Curie Intra-European Research Fellowship. In 2015, Dr Scanlan was one of the first awardees of the prestigious Royal Society-Science Foundation Ireland University Research Fellowship and moved to the APC Microbiome Institute at UCC to take up the position. Pauline was appointed as a lecturer at the School of Microbiology in 2017.

Research Interests

• Ecology and evolution of the gut microbiome
• Prevalence, diversity and function of gut microbial eukarya (Fungi and Protists e.g. Blastocystis)
• Bacteriophages
• Host-parasite coevolution
• Chronic Disease


My main research interests centre on the ecology and evolution of the human gut microbiome. I am interested in understanding how inter-specific interactions between microbes at different scales and in response to different abiotic factors affect the diversity, structure and function of the gut microbiome, and ultimately host health. To address these research questions I am developing in vitro and in vivo model systems to study the ecology and evolution of the gut microbiome and complementing this approach by studying naturally occurring communities of gut microbes. I am also interested in better understanding the global prevalence, diversity, and role of specific microbes such as Blastocystis and fungi in human health and disease.
https://scholar.google.com/citations?user=iOCYO2sAAAAJ&hl=en

Research Grants

 ProjectFunding
Body
Start DateEnd DateAward
Gut Microbiome Evolution: Implications for Microbial Diversity and Functuality and Host Health.Enterprise Irl18-AUG-1718-MAY-18€7,994.00
Bacteria-Bacteriophage coevolution in the human gutScience Foundation Ireland
SFI/AMR PhD (2) Joseph Pennycook - Elucidating the impact of clinical & subclinical levels of different antibiotics in gut microbiota ecology and functionalityScience Foundation of Ireland01-APR-1831-MAR-22€233,520.00

Publications

Peer Reviewed Journals

 YearPublication
(2018)'The intestinal protist Blastocystis is not a common member of the healthy infant gut microbiota in a Westernized country (Ireland)'
Scanlan PD;Hill CJ;Ross RP;Ryan CA;Stanton C;Cotter PD; (2018) 'The intestinal protist Blastocystis is not a common member of the healthy infant gut microbiota in a Westernized country (Ireland)'. Journal Of Parasitology, [DOI] [Details]
(2017)'The Fungal Frontier: A Comparative Analysis of Methods Used in the Study of the Human Gut Mycobiome'
Huseyin,Chloe E.,Rubio,Raul Cabrera,O’Sullivan,Orla,Cotter,Paul D.,Scanlan,Pauline D. (2017) 'The Fungal Frontier: A Comparative Analysis of Methods Used in the Study of the Human Gut Mycobiome'. Frontiers In Microbiology, 8 (1432)   [DOI] [Full Text] [Details]
(2017)'Modification of Escherichia coli-bacteriophage interactions by surfactants and antibiotics in vitro'
Scanlan, PD;Bischofberger, AM;Hall, AR (2017) 'Modification of Escherichia coli-bacteriophage interactions by surfactants and antibiotics in vitro'. Fems Microbiology Ecology, 93 [DOI] [Full Text] [Details]
(2017)'Within-host interference competition can prevent invasion of rare parasites'
Quigley BJZ;Brown SP;Leggett HC;Scanlan PD;Buckling A; (2017) 'Within-host interference competition can prevent invasion of rare parasites'. Journal Of Parasitology, [DOI] [Details]
(2017)'Bacteria-Bacteriophage Coevolution in the Human Gut: Implications for Microbial Diversity and Functionality'
Scanlan PD; (2017) 'Bacteria-Bacteriophage Coevolution in the Human Gut: Implications for Microbial Diversity and Functionality'. Trends In Microbiology, 25 (8) [DOI] [Details]
(2017)'Parasite genetic distance and local adaptation in co-evolving bacteria-bacteriophage populations'
Scanlan, PD;Hall, AR;Buckling, A (2017) 'Parasite genetic distance and local adaptation in co-evolving bacteria-bacteriophage populations'. Molecular Ecology, 26 :1747-1755 [DOI] [Full Text] [Details]
(2016)'Prevalence and genetic diversity of Blastocystis in family units living in the United States'
Scanlan, Pauline D.; Knight, Rob; Song, Se Jin; Ackermann, Gail; Cotter, Paul D. (2016) 'Prevalence and genetic diversity of Blastocystis in family units living in the United States'. Infection Genetics And Evolution, 45 :95-97   [DOI] [Full Text] [Details]
(2016)'Iron availability shapes the evolution of bacteriocin resistance in Pseudomonas aeruginosa'
Inglis RF;Scanlan P;Buckling A; (2016) 'Iron availability shapes the evolution of bacteriocin resistance in Pseudomonas aeruginosa'. ISME Journal, 10 (8) [DOI] [Details]
(2016)'Adaptation to abiotic conditions drives local adaptation in bacteria and viruses coevolving in heterogeneous environments'
Gorter FA;Scanlan PD;Buckling A; (2016) 'Adaptation to abiotic conditions drives local adaptation in bacteria and viruses coevolving in heterogeneous environments'. Biology Letters, 12 (2) [DOI] [Details]
(2015)'Parasite host range and the evolution of host resistance'
Gorter FA;Hall AR;Buckling A;Scanlan PD; (2015) 'Parasite host range and the evolution of host resistance'. Journal of Evolutionary Biology, 28 (5) [DOI] [Details]
(2015)'Coevolution with bacteriophages drives genome-wide host evolution and constrains the acquisition of abiotic-beneficial mutations'
Scanlan PD;Hall AR;Blackshields G;Friman VP;Davis MR;Goldberg JB;Buckling A; (2015) 'Coevolution with bacteriophages drives genome-wide host evolution and constrains the acquisition of abiotic-beneficial mutations'. Molecular biology and evolution, 32 (6) [DOI] [Details]
(2015)'Development and Application of a Blastocystis Subtype-Specific PCR Assay Reveals that Mixed-Subtype Infections Are Common in a Healthy Human Population'
Scanlan, PD;Stensvold, CR;Cotter, PD (2015) 'Development and Application of a Blastocystis Subtype-Specific PCR Assay Reveals that Mixed-Subtype Infections Are Common in a Healthy Human Population'. Applied and Environmental Microbiology, 81 :4071-4076 [DOI] [Details]
(2015)'Experimental evolution and bacterial resistance: (co)evolutionary costs and trade-offs as opportunities in phage therapy research'
Scanlan PD;Buckling A;Hall AR; (2015) 'Experimental evolution and bacterial resistance: (co)evolutionary costs and trade-offs as opportunities in phage therapy research'. Bacteriophage, 5 (2) [DOI] [Details]
(2014)'Loss of social behaviours in populations of Pseudomonas aeruginosa infecting lungs of patients with cystic fibrosis'
Jiricny N;Molin S;Foster K;Diggle SP;Scanlan PD;Ghoul M;Johansen HK;Santorelli LA;Popat R;West SA;Griffin AS; (2014) 'Loss of social behaviours in populations of Pseudomonas aeruginosa infecting lungs of patients with cystic fibrosis'. Plos One, 9 (1) [DOI] [Full Text] [Details]
(2013)'No effect of host-parasite co-evolution on host range expansion'
Scanlan PD;Hall AR;Burlinson P;Preston G;Buckling A; (2013) 'No effect of host-parasite co-evolution on host range expansion'. Journal of Evolutionary Biology, 26 (1) [DOI] [Details]
(2013)'Blastocystis: getting to grips with our guileful guest'
Scanlan PD;Stensvold CR; (2013) 'Blastocystis: getting to grips with our guileful guest'. Trends In Parasitology, 29 (11) [DOI] [Details]
(2012)'Multiplicity of infection does not accelerate infectivity evolution of viral parasites in laboratory microcosms'
Hall AR;Scanlan PD;Leggett HC;Buckling A; (2012) 'Multiplicity of infection does not accelerate infectivity evolution of viral parasites in laboratory microcosms'. Journal of Evolutionary Biology, 25 (2) [DOI] [Details]
(2012)'Co-evolution with lytic phage selects for the mucoid phenotype of Pseudomonas fluorescens SBW25'
Scanlan PD;Buckling A; (2012) 'Co-evolution with lytic phage selects for the mucoid phenotype of Pseudomonas fluorescens SBW25'. ISME Journal, 6 (6) [DOI] [Details]
(2012)'Blastocystis: past pitfalls and future perspectives'
Scanlan PD; (2012) 'Blastocystis: past pitfalls and future perspectives'. Trends In Parasitology, 28 (8) [DOI] [Details]
(2011)'Bacteria-phage coevolution and the emergence of generalist pathogens'
Hall AR;Scanlan PD;Buckling A; (2011) 'Bacteria-phage coevolution and the emergence of generalist pathogens'. The American Naturalist, 177 (1) [DOI] [Details]
(2011)'Genetic basis of infectivity evolution in a bacteriophage'
Scanlan PD;Hall AR;Lopez-Pascua LD;Buckling A; (2011) 'Genetic basis of infectivity evolution in a bacteriophage'. Molecular Ecology, 20 (5) [DOI] [Details]
(2009)'Culture-independent analysis of desulfovibrios in the human distal colon of healthy, colorectal cancer and polypectomized individuals'
Scanlan, PD;Shanahan, F;Marchesi, JR (2009) 'Culture-independent analysis of desulfovibrios in the human distal colon of healthy, colorectal cancer and polypectomized individuals'. Fems Microbiology Ecology, 69 :213-221 [DOI] [Details]
(2008)'Culture-independent analysis of the gut microbiota in colorectal cancer and polyposis'
Scanlan, PD;Shanahan, F;Clune, Y;Collins, JK;O'Sullivan, GC;O'Riordan, M;Holmes, E;Wang, YL;Marchesi, JR (2008) 'Culture-independent analysis of the gut microbiota in colorectal cancer and polyposis'. Environmental Microbiology, 10 :789-798 [DOI] [Details]
(2008)'Micro-eukaryotic diversity of the human distal gut microbiota: qualitative assessment using culture-dependent and -independent analysis of faeces'
Scanlan, PD;Marchesi, JR (2008) 'Micro-eukaryotic diversity of the human distal gut microbiota: qualitative assessment using culture-dependent and -independent analysis of faeces'. ISME Journal, 2 :1183-1193 [DOI] [Details]
(2008)'Human methanogen diversity and incidence in healthy and diseased colonic groups using mcrA gene analysis'
Scanlan, PD;Shanahan, F;Marchesi, JR (2008) 'Human methanogen diversity and incidence in healthy and diseased colonic groups using mcrA gene analysis'. BMC Microbiology, 8 [DOI] [Full Text] [Details]
(2007)'Rapid and noninvasive metabonomic characterization of inflammatory bowel disease'
Marchesi, JR;Holmes, E;Khan, F;Kochhar, S;Scanlan, P;Shanahan, F;Wilson, ID;Wang, YL (2007) 'Rapid and noninvasive metabonomic characterization of inflammatory bowel disease'. Journal of proteome research, 6 :546-551 [DOI] [Details]
(2006)'Culture-independent analyses of temporal variation of the dominant fecal microbiota and targeted bacterial subgroups in Crohn's disease'
Scanlan, PD;Shanahan, F;O'Mahony, C;Marchesi, JR (2006) 'Culture-independent analyses of temporal variation of the dominant fecal microbiota and targeted bacterial subgroups in Crohn's disease'. Journal of Clinical Microbiology, 44 :3980-3988 [DOI] [Details]
(2009)'Culture-independent analysis of desulfovibrios in the human distal colon of healthy, colorectal cancer and polypectomized individuals'
Scanlan, Pauline D. and Shanahan, Fergus and Marchesi, Julian R. (2009) 'Culture-independent analysis of desulfovibrios in the human distal colon of healthy, colorectal cancer and polypectomized individuals'. Fems Microbiology Ecology, 69 (2):213-221 [Details]
(2008)'Culture-independent analysis of the gut microbiota in colorectal cancer and polyposis'
Scanlan, PD,Shanahan, F,Clune, Y,Collins, JK,O'Sullivan, GC,O'Riordan, M,Holmes, E,Wang, YL,Marchesi, JR; (2008) 'Culture-independent analysis of the gut microbiota in colorectal cancer and polyposis'. Environmental Microbiology, 10 (3):789-798 [DOI] [Details]
(2008)'Culture-independent analysis of the gut microbiota in colorectal cancer and polyposis (vol 10, pg 789, 2008)'
Scanlan, P. D.,Shanahan, F.,Clune, Y.,Collins, J. K.,O'Sullivan, G. C.,O'Riordan, M.,Holmes, E.,Wang, Y. L.,Marchesi, J. R. (2008) 'Culture-independent analysis of the gut microbiota in colorectal cancer and polyposis (vol 10, pg 789, 2008)'. Environ Microbiol, 10 (55):1382-13821382   [Details]
(2007)'Rapid and noninvasive metabonomic characterization of inflammatory bowel disease'
Marchesi, J. R.,Holmes, E.,Khan, F.,Kochhar, S.,Scanlan, P.,Shanahan, F.,Wilson, I. D.,Wang, Y. L. (2007) 'Rapid and noninvasive metabonomic characterization of inflammatory bowel disease'. Journal of Proteome Research, 6 (2):546-551   [Details]
(2007)'Rapid and noninvasive metabonomic characterization of inflammatory bowel disease'
Marchesi, JR,Holmes, E,Khan, F,Kochhar, S,Scanlan, P,Shanahan, F,Wilson, ID,Wang, YL (2007) 'Rapid and noninvasive metabonomic characterization of inflammatory bowel disease'. Journal of Proteome Research, 6 :546-551 [DOI] [Details]
(2007)'Culture-independent analyses of temporal variation of the dominant fecal microbiota and targeted bacterial subgroups in Crohn's disease (vol 44, pg 3980, 2006)'
Scanlan, P. D.,Shanahan, F.,O'Mahony, C.,Marchesi, J. R. (2007) 'Culture-independent analyses of temporal variation of the dominant fecal microbiota and targeted bacterial subgroups in Crohn's disease (vol 44, pg 3980, 2006)'. J Clin Microbiol, 45 (55):1671-16711671   [Details]
(2006)'Culture-independent analyses of temporal variation of the dominant fecal microbiota and targeted bacterial subgroups in Crohn's disease'
Scanlan, P. D.,Shanahan, F.,O'Mahony, C.,Marchesi, J. R. (2006) 'Culture-independent analyses of temporal variation of the dominant fecal microbiota and targeted bacterial subgroups in Crohn's disease'. Journal of Clinical Microbiology, 44 (11):3980-3988   [Details]
(2005)'Serial culture-independent analysis of the enteric microbial community in Crohn's disease and disease controls'
Marchesi, J.,Scanlan, P.,Codling, C.,MacSharry, J.,Kiely, B.,O'Mahony, L.,Collins, J. K.,Quigley, E.,Shanahan, F. (2005) 'Serial culture-independent analysis of the enteric microbial community in Crohn's disease and disease controls'. Gastroenterology, 128 (44)   [Details]

Professional Activities

Employment

 EmployerPositionFrom / To
APC Microbiome Institute, University College Cork Royal Society – Science Foundation Ireland University Research Fellow/
School of Microbiology, University College Cork Lecturer01-JUL-17 /

Education

 YearInstitutionQualificationSubject
2002UCC BScPlant and Microbiology Biotechnology
2007UCC PhDMedicine
2014UCC PG CertificateTeaching and Learning in Higher Education
2016UCC PG CertificateProfessional Skills for Research Leaders

Professional Associations

 AssociationFunctionFrom / To
Society for Applied Microbiology Member/
European Society for Evolutionary Biology Member/
Microbiology Society Member/

Research Information

External Collaborators

 NameOrganisation / InstituteCountry
Dr Alex Hall ETH ZurichSWITZERLAND
Prof. Angus Buckling University of ExeterUNITED KINGDOM
Dr Rune Stensvold Staten Serum InsitutDENMARK
Prof. Maria Gloria Dominguez-Bello New York UniversityU.S.A.
Dr Paul Cotter Teagasc, MooreparkIRELAND

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