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4. Sinead Lordan

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Biography

Dr. Sinéad Lordan is a graduate of University College Cork, completing her PhD (Nutritional Biochemistry) in 2008 under the supervision of Professor Nora O’Brien, School of Food and Nutritional Sciences, and Dr. John Mackrill, Physiology Department.  ‍

Research Interests

Research interests include investigating the biological effects of nutrients and phytochemicals on various cellular functions (e.g. cell death, immune response, cell repair) and in particular, investigations into cellular pathways that can be manipulated to offer possible therapeutic solutions.  The implications of cellular uptake and bioaccumulation of compounds and their effect on the functional performance of the cell is another area of interest.                       

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Publications

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Peer Reviewed Journals

	Year	Publication
	(2013)	'The alpha-amylase and alpha-glucosidase inhibitory effects of Irish seaweed extracts' Lordan S, Smyth TJ, Soler-Vila A, Stanton C, Ross RP (2013) 'The alpha-amylase and alpha-glucosidase inhibitory effects of Irish seaweed extracts'. Food Chemistry, 141 (3):2170-2176 [DOI] [Details]
	(2012)	'Effect of serum concentration on the cytotoxicity of clay particles' Lordan S, Higginbotham CL (2012) 'Effect of serum concentration on the cytotoxicity of clay particles'. Cell biology international, 36 (1):57-61 [DOI] [Details]
	(2011)	'Marine bioactives as functional food ingredients: potential to reduce the incidence of chronic diseases' Lordan S, Ross RP, Stanton C (2011) 'Marine bioactives as functional food ingredients: potential to reduce the incidence of chronic diseases'. Marine Drugs, 9 (6):1056-1100 [DOI] [Details]
	(2011)	'Cytotoxic effects induced by unmodified and organically modified nanoclays in the human hepatic HepG2 cell line' Lordan S, Kennedy JE, Higginbotham CL (2011) 'Cytotoxic effects induced by unmodified and organically modified nanoclays in the human hepatic HepG2 cell line'. Journal of Applied Toxicology, 31 (1):27-35 [DOI] [Details]
	(2010)	'Characterisation of the effects of a titanium micro particle filler on a polyether-block-amide host matrix' Lyons JG, Kennedy JE, Lordan S, Geever LM, Higginbotham CL (2010) 'Characterisation of the effects of a titanium micro particle filler on a polyether-block-amide host matrix'. Journal Of Materials Science, 45 :3204-3214 [DOI] [Details]
	(2009)	'Oxysterols and mechanisms of apoptotic signaling: implications in the pathology of degenerative diseases' Lordan S, Mackrill JJ, O'Brien NM (2009) 'Oxysterols and mechanisms of apoptotic signaling: implications in the pathology of degenerative diseases'. Journal of Nutritional Biochemistry, 20 (5):321-336 [DOI] [Details]
	(2009)	'The role of calcium in apoptosis induced by 7beta-hydroxycholesterol and cholesterol-5beta,6beta-epoxide' Lordan S, O'Brien NM, Mackrill JJ (2009) 'The role of calcium in apoptosis induced by 7beta-hydroxycholesterol and cholesterol-5beta,6beta-epoxide'. Journal of Biochemical and Molecular Toxicology, 23 (5):324-332 [DOI] [Details]
	(2008)	'Involvement of Fas signalling in 7beta-hydroxycholesterol-and cholesterol-5beta,6beta-epoxide-induced apoptosis' Lordan S, Mackrill JJ, O'Brien NM (2008) 'Involvement of Fas signalling in 7beta-hydroxycholesterol-and cholesterol-5beta,6beta-epoxide-induced apoptosis'. International Journal of Toxicology, 27 (3):279-285 [DOI] [Details]
	(2008)	'Effects of apigenin, lycopene and astaxanthin on 7 beta-hydroxycholesterol-induced apoptosis and Akt phosphorylation in U937 cells' Lordan S, O'Neill C, O'Brien NM; (2008) 'Effects of apigenin, lycopene and astaxanthin on 7 beta-hydroxycholesterol-induced apoptosis and Akt phosphorylation in U937 cells'. British Journal of Nutrition, 100 (2):287-296 [DOI] [Full Text] [Details]
	(2007)	'Death-signaling pathways in human myeloid cells by oxLDL and its cytotoxic components 7 beta-hydroxycholesterol and cholesterol-5 beta,6 beta-epoxide' Lordan, S;O'Callaghan, YC;O'Brien, NM (2007) 'Death-signaling pathways in human myeloid cells by oxLDL and its cytotoxic components 7 beta-hydroxycholesterol and cholesterol-5 beta,6 beta-epoxide'. Journal of Biochemical and Molecular Toxicology, 21 :362-372 [Details]
	(2007)	'Inadequate dietary calcium and vitamin D intakes in renal-transplant recipients in Ireland' Lynch IT, Eustace JA, Plant WD, Cashman KD, O’Keefe M, Lordan S, Moloney R (2007) 'Inadequate dietary calcium and vitamin D intakes in renal-transplant recipients in Ireland'. Journal Of Renal Nutrition, 17 (6):408-415 [Details]

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Conference Publications

	Year	Publication
	(2012)	2nd Kiel Food Science Symposium Lordan S, Stanton C and Ross RP (2012) In vitro evaluation of Irish seaweed extracts as inhibitors of key enzymes linked to type 2 diabetes 2nd Kiel Food Science Symposium [Details]
	(2012)	NutraMara Conference Collins K, Lordan S, Stanton C, Ross P (2012) Screening and analysis of Irish seaweed extracts for prebiotic potential NutraMara Conference [Details]
	(2012)	NutraMara Conference Lordan S, Stanton C, Ross P (2012) Evaluation of Irish seaweed extracts as inhibitors of starch-digestive enzymes NutraMara Conference [Details]
	(2012)	Marine Microbiology and Biotechnology Conference Collins K, Lordan S, Fitzgerald G, Ross RP, Stanton C (2012) Prebiotic potential of crude Irish seaweed extracts Marine Microbiology and Biotechnology Conference [Details]
	(2009)	22nd European Conference on Biomaterials Lordan S, Devery SM, Higginbotham CL (2009) The cytotoxic effects of non-organically modified and organically modified nanoclays 22nd European Conference on Biomaterials [Details]
	(2008)	Nutrition Society Meeting Lordan S, Mackrill JJ, O'Brien NM (2008) Influence of intracellular calcium on apoptosis in differentiated U937 cells following long-term exposure to oxysterols Nutrition Society Meeting [DOI] [Details]
	(2007)	Joint Health Research Day Lordan S, O’Neill C, O’Brien NM (2007) The effects of apigenin, lycopene and astaxanthin on 7β-hydroxycholesterol-induced apoptosis in U937 cells Joint Health Research Day [Details]
	(2007)	37th Annual Research Conference Food, Nutrition and Consumer Sciences Lordan S, Mackrill JJ, O’Brien NM (2007) Involvement of calcium signalling in oxysterol-induced apoptosis in differentiated U937 cells 37th Annual Research Conference Food, Nutrition and Consumer Sciences [Details]
	(2006)	Nutrition Society Meeting Lordan S, O'Callaghan YC, O'Brien NM (2006) Oxidised low-density lipoprotein- and oxysterol-induced cell death in U937 and HL-60 blood cells Nutrition Society Meeting [Details]
	(2006)	The 14th Annual Cork University Hospital Medical Faculty Research Day Lordan S, O’Callaghan, O’Brien NM (2006) An investigation into the caspase-2 signalling pathway of oxLDL- and oxysterol-induced apoptosis in U937 cells The 14th Annual Cork University Hospital Medical Faculty Research Day [Details]
	(2005)	Nutrition Society Meeting - Irish Section Lordan S, O'Callaghan YC, O'Brien NM (2005) An investigation of the anti-apoptotic efficiency of apigenin, astaxanthin and lycopene in cholesterol oxide-treated human monocytic blood cells Nutrition Society Meeting - Irish Section [Details]
	(2005)	The 13th Annual Cork University Hospital Medical Faculty Research Day Lordan S, O’Callaghan, O’Brien NM (2005) Comparison of the cytotoxic effects of oxidised low density lipoprotein and oxysterols in human monocytic cell lines The 13th Annual Cork University Hospital Medical Faculty Research Day [Details]

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Professional Activities

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Education

	Year	Institution	Qualification	Subject
	2008	University College Cork	PHD	Nutritional Biochemistry
	2004	University College Cork	BSC (HONS)	Nutritional Sciences

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Employment

	Employer	Position	From / To
	School of Food & Nutritional Sciences, University College Cork	Research Support Officer	10-MAR-14 / 31-DEC-17
	Teagasc Food Research Centre Moorepark	Research Officer	01-SEP-10 / 01-MAR-14
	Bioscience Research Institute, Athlone Institute of Technology	Post-Doctoral Research Fellow	01-NOV-08 / 31-AUG-10
	School of Food & Nutritional Sciences, University College Cork	Research Assistant	01-FEB-08 / 31-OCT-08

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Conference Contributions

	Year	Publication
	(2012)	NutraMara Conference, Lordan S (2012) Evaluation of Irish seaweed extracts as inhibitors of starch-digestive enzymes. [Poster Presentation], NutraMara Conference, Dublin, Ireland . [Details]
	(2012)	2nd Kiel Food Science Symposium, Lordan S (2012) In vitro evaluation of Irish seaweed extracts as inhibitors of key enzymes linked to type 2 diabetes. [Poster Presentation], 2nd Kiel Food Science Symposium, Germany . [Details]
	(2009)	22nd European Conference on Biomaterials, Lordan S (2009) The cytotoxic effects of non-organically modified and organically modified nanoclays. [Poster Presentation], 22nd European Conference on Biomaterials, Switzerland . [Details]
	(2008)	Nutrition Society Meeting, Lordan S (2008) Influence of intracellular calcium on apoptosis in differentiated U937 cells following long-term exposure to oxysterols. [Poster Presentation], Nutrition Society Meeting, Dublin . [Details]
	(2007)	Joint Health Research Day, Lordan S (2007) The effects of apigenin, lycopene and astaxanthin on 7β-hydroxycholesterol-induced apoptosis in U937 cells. [Poster Presentation], Joint Health Research Day, UCC . [Details]
	(2007)	Plant Science Seminar, Lordan S (2007) Oxysterol-induced cell death. [Oral Presentation], Plant Science Seminar, Cork . [Details]
	(2007)	37th Annual Research Conference Food, Nutrition and Consumer Sciences, Lordan S (2007) Involvement of calcium signalling in oxysterol-induced apoptosis in differentiated U937 cells. [Poster Presentation], 37th Annual Research Conference Food, Nutrition and Consumer Sciences, Cork . [Details]
	(2006)	14th Annual Research Day (Faculty of Medicine & Health, UCC), Lordan S (2006) An investigation into the caspase-2 signalling pathway of oxLDL-and oxysterol-induced apoptosis in U937 cells. [Oral Presentation], 14th Annual Research Day (Faculty of Medicine & Health, UCC), UCC, Cork , 01-JAN-06 - 01-JAN-06. [Details]
	(2006)	Nutrition Society Meeting, Lordan, S., O'Callaghan, Y.C. and O'Brien, N.M. (2006) OxLDL- and oxysterol-induced cell death in U937 and HL-60 blood cells. [Oral Presentation], Nutrition Society Meeting, Aberdeen, Scotland , 01-JUL-06 - 01-JUL-06. [Details]
	(2005)	13th Annual Research Day (Faculty of Medicine and Health, UCC), Lordan S (2005) Comparison of the cytotoxic effects of oxidised low density lipoprotein and oxysterols in human monocytic cells. [Poster Presentation], 13th Annual Research Day (Faculty of Medicine and Health, UCC), Cork, Ireland , 22-JUN-05 - 22-JUN-05. [Details]
	(2005)	Nutrition Society Postgraduate Meeting, Lordan S (2005) Oxysterol-induced cell death. [Oral Presentation], Nutrition Society Postgraduate Meeting, Dublin . [Details]
	(2005)	Nutrition Society Meeting, Lordan S (2005) An investigation of the anti-apoptotic efficiency of apigenin, astaxanthin and lycopene in cholesterol oxide-treated human monocytic blood cells. [Oral Presentation], Nutrition Society Meeting, Belfast . [Details]

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Teaching Activities

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Teaching Interests