Research Profile

Sinead Lordan

Biography

Dr. Sinéad Lordan is a graduate of University College Cork, completing her PhD (Nutritional Biochemistry) in 2008 under the supervision of Professor Nora O’Brien, School of Food and Nutritional Sciences, and Dr. John Mackrill, Physiology Department.  Following this, Sinéad accepted a postdoctoral fellowship at the Bioscience Research Institute, Athlone Institute of Technology, focusing her research activities on the cellular effects of nanoparticles.  In 2010, Sinéad joined Teagasc Food Research Centre Moorepark as a Research Officer on the NutraMara programme where her work involved screening and profiling marine bioactives with potential to positively impact on human health.  During her research career, Sinéad has published extensively and has contributed to a number of conferences, both nationally and internationally.

In March 2014, Sinéad joined the Vitamin D Research Group, University College Cork, as Project Manager of the European FP7 project, ODIN.  ODIN is a four-year collaborative project which aims to develop standardised tools for measurement of vitamin D levels and to propose novel food-based solutions to help eradicate vitamin D deficiency in affected individuals [www.odin-vitd.eu].

Research Interests

Research interests include investigating the biological effects of nutrients and phytochemicals on various cellular functions (e.g. cell death, immune response, cell repair) and in particular, investigations into cellular pathways that can be manipulated to offer possible therapeutic solutions.  The implications of cellular uptake and bioaccumulation of compounds and their effect on the functional performance of the cell is another area of interest.                       


Publications

Peer Reviewed Journals

 YearPublication
(2013)'The alpha-amylase and alpha-glucosidase inhibitory effects of Irish seaweed extracts'
Lordan S, Smyth TJ, Soler-Vila A, Stanton C, Ross RP (2013) 'The alpha-amylase and alpha-glucosidase inhibitory effects of Irish seaweed extracts'. Food Chemistry, 141 (3):2170-2176 [DOI] [Details]
(2012)'Effect of serum concentration on the cytotoxicity of clay particles'
Lordan S, Higginbotham CL (2012) 'Effect of serum concentration on the cytotoxicity of clay particles'. Cell biology international, 36 (1):57-61 [DOI] [Details]
(2011)'Marine bioactives as functional food ingredients: potential to reduce the incidence of chronic diseases'
Lordan S, Ross RP, Stanton C (2011) 'Marine bioactives as functional food ingredients: potential to reduce the incidence of chronic diseases'. Marine Drugs, 9 (6):1056-1100 [DOI] [Details]
(2011)'Cytotoxic effects induced by unmodified and organically modified nanoclays in the human hepatic HepG2 cell line'
Lordan S, Kennedy JE, Higginbotham CL (2011) 'Cytotoxic effects induced by unmodified and organically modified nanoclays in the human hepatic HepG2 cell line'. Journal of Applied Toxicology, 31 (1):27-35 [DOI] [Details]
(2010)'Characterisation of the effects of a titanium micro particle filler on a polyether-block-amide host matrix'
Lyons JG, Kennedy JE, Lordan S, Geever LM, Higginbotham CL (2010) 'Characterisation of the effects of a titanium micro particle filler on a polyether-block-amide host matrix'. Journal Of Materials Science, 45 :3204-3214 [DOI] [Details]
(2009)'Oxysterols and mechanisms of apoptotic signaling: implications in the pathology of degenerative diseases'
Lordan S, Mackrill JJ, O'Brien NM (2009) 'Oxysterols and mechanisms of apoptotic signaling: implications in the pathology of degenerative diseases'. Journal of Nutritional Biochemistry, 20 (5):321-336 [DOI] [Details]
(2009)'The role of calcium in apoptosis induced by 7beta-hydroxycholesterol and cholesterol-5beta,6beta-epoxide'
Lordan S, O'Brien NM, Mackrill JJ (2009) 'The role of calcium in apoptosis induced by 7beta-hydroxycholesterol and cholesterol-5beta,6beta-epoxide'. Journal of Biochemical and Molecular Toxicology, 23 (5):324-332 [DOI] [Details]
(2008)'Involvement of Fas signalling in 7beta-hydroxycholesterol-and cholesterol-5beta,6beta-epoxide-induced apoptosis'
Lordan S, Mackrill JJ, O'Brien NM (2008) 'Involvement of Fas signalling in 7beta-hydroxycholesterol-and cholesterol-5beta,6beta-epoxide-induced apoptosis'. International Journal of Toxicology, 27 (3):279-285 [DOI] [Details]
(2008)'Effects of apigenin, lycopene and astaxanthin on 7 beta-hydroxycholesterol-induced apoptosis and Akt phosphorylation in U937 cells'
Lordan S, O'Neill C, O'Brien NM; (2008) 'Effects of apigenin, lycopene and astaxanthin on 7 beta-hydroxycholesterol-induced apoptosis and Akt phosphorylation in U937 cells'. British Journal of Nutrition, 100 (2):287-296 [DOI] [CORA Link] [Details]
(2007)'Inadequate dietary calcium and vitamin D intakes in renal-transplant recipients in Ireland'
Lynch IT, Eustace JA, Plant WD, Cashman KD, O’Keefe M, Lordan S, Moloney R (2007) 'Inadequate dietary calcium and vitamin D intakes in renal-transplant recipients in Ireland'. Journal Of Renal Nutrition, 17 (6):408-415 [Details]
(2007)'Death-signaling pathways in human myeloid cells by oxLDL and its cytotoxic components 7 beta-hydroxycholesterol and cholesterol-5 beta,6 beta-epoxide'
Lordan S, O'Callaghan YC, O'Brien NM (2007) 'Death-signaling pathways in human myeloid cells by oxLDL and its cytotoxic components 7 beta-hydroxycholesterol and cholesterol-5 beta,6 beta-epoxide'. Journal of Biochemical and Molecular Toxicology, 21 :362-372 [Details]

Conference Publications

 YearPublication
(2012)2nd Kiel Food Science Symposium
Lordan S, Stanton C and Ross RP (2012) In vitro evaluation of Irish seaweed extracts as inhibitors of key enzymes linked to type 2 diabetes 2nd Kiel Food Science Symposium [Details]
(2012)NutraMara Conference
Collins K, Lordan S, Stanton C, Ross P (2012) Screening and analysis of Irish seaweed extracts for prebiotic potential NutraMara Conference [Details]
(2012)NutraMara Conference
Lordan S, Stanton C, Ross P (2012) Evaluation of Irish seaweed extracts as inhibitors of starch-digestive enzymes NutraMara Conference [Details]
(2012)Marine Microbiology and Biotechnology Conference
Collins K, Lordan S, Fitzgerald G, Ross RP, Stanton C (2012) Prebiotic potential of crude Irish seaweed extracts Marine Microbiology and Biotechnology Conference [Details]
(2009)22nd European Conference on Biomaterials
Lordan S, Devery SM, Higginbotham CL (2009) The cytotoxic effects of non-organically modified and organically modified nanoclays 22nd European Conference on Biomaterials [Details]
(2008)Nutrition Society Meeting
Lordan S, Mackrill JJ, O'Brien NM (2008) Influence of intracellular calcium on apoptosis in differentiated U937 cells following long-term exposure to oxysterols Nutrition Society Meeting [DOI] [Details]
(2007)Joint Health Research Day
Lordan S, O’Neill C, O’Brien NM (2007) The effects of apigenin, lycopene and astaxanthin on 7β-hydroxycholesterol-induced apoptosis in U937 cells Joint Health Research Day [Details]
(2007)37th Annual Research Conference Food, Nutrition and Consumer Sciences
Lordan S, Mackrill JJ, O’Brien NM (2007) Involvement of calcium signalling in oxysterol-induced apoptosis in differentiated U937 cells 37th Annual Research Conference Food, Nutrition and Consumer Sciences [Details]
(2006)Nutrition Society Meeting
Lordan S, O'Callaghan YC, O'Brien NM (2006) Oxidised low-density lipoprotein- and oxysterol-induced cell death in U937 and HL-60 blood cells Nutrition Society Meeting [Details]
(2006)The 14th Annual Cork University Hospital Medical Faculty Research Day
Lordan S, O’Callaghan, O’Brien NM (2006) An investigation into the caspase-2 signalling pathway of oxLDL- and oxysterol-induced apoptosis in U937 cells The 14th Annual Cork University Hospital Medical Faculty Research Day [Details]
(2005)Nutrition Society Meeting - Irish Section
Lordan S, O'Callaghan YC, O'Brien NM (2005) An investigation of the anti-apoptotic efficiency of apigenin, astaxanthin and lycopene in cholesterol oxide-treated human monocytic blood cells Nutrition Society Meeting - Irish Section [Details]
(2005)The 13th Annual Cork University Hospital Medical Faculty Research Day
Lordan S, O’Callaghan, O’Brien NM (2005) Comparison of the cytotoxic effects of oxidised low density lipoprotein and oxysterols in human monocytic cell lines The 13th Annual Cork University Hospital Medical Faculty Research Day [Details]

Professional Activities

Education

 YearInstitutionQualificationSubject
2008University College Cork PHDNutritional Biochemistry
2004University College Cork BSC (HONS)Nutritional Sciences

Employment

 EmployerPositionFrom / To
Teagasc Food Research Centre Moorepark Research Officer01-SEP-10 / 01-MAR-14
Bioscience Research Institute, Athlone Institute of Technology Post-Doctoral Research Fellow01-NOV-08 / 31-AUG-10
School of Food and Nutritional Sciences, University College Cork Research Assistant01-FEB-08 / 31-OCT-08

Honours and Awards

 YearTitleAwarding Body
2012Best Poster Presentation Kiel Food Science Symposium, Germany
2004The Barry O'Mullane Postgraduate Scholarship University College Cork

Conference Contributions

 YearPublication
(2012)NutraMara Conference,
Lordan S (2012) Evaluation of Irish seaweed extracts as inhibitors of starch-digestive enzymes. [Poster Presentation], NutraMara Conference, Dublin, Ireland . [Details]
(2012)2nd Kiel Food Science Symposium,
Lordan S (2012) In vitro evaluation of Irish seaweed extracts as inhibitors of key enzymes linked to type 2 diabetes. [Poster Presentation], 2nd Kiel Food Science Symposium, Germany . [Details]
(2009)22nd European Conference on Biomaterials,
Lordan S (2009) The cytotoxic effects of non-organically modified and organically modified nanoclays. [Poster Presentation], 22nd European Conference on Biomaterials, Switzerland . [Details]
(2008)Nutrition Society Meeting,
Lordan S (2008) Influence of intracellular calcium on apoptosis in differentiated U937 cells following long-term exposure to oxysterols. [Poster Presentation], Nutrition Society Meeting, Dublin . [Details]
(2007)Joint Health Research Day,
Lordan S (2007) The effects of apigenin, lycopene and astaxanthin on 7β-hydroxycholesterol-induced apoptosis in U937 cells. [Poster Presentation], Joint Health Research Day, UCC . [Details]
(2007)Plant Science Seminar,
Lordan S (2007) Oxysterol-induced cell death. [Oral Presentation], Plant Science Seminar, Cork . [Details]
(2007)37th Annual Research Conference Food, Nutrition and Consumer Sciences,
Lordan S (2007) Involvement of calcium signalling in oxysterol-induced apoptosis in differentiated U937 cells. [Poster Presentation], 37th Annual Research Conference Food, Nutrition and Consumer Sciences, Cork . [Details]
(2006)14th Annual Research Day (Faculty of Medicine & Health, UCC),
Lordan S (2006) An investigation into the caspase-2 signalling pathway of oxLDL-and oxysterol-induced apoptosis in U937 cells. [Oral Presentation], 14th Annual Research Day (Faculty of Medicine & Health, UCC), UCC, Cork , 01-JAN-06 - 01-JAN-06. [Details]
(2006)Nutrition Society Meeting,
Lordan, S., O'Callaghan, Y.C. and O'Brien, N.M. (2006) OxLDL- and oxysterol-induced cell death in U937 and HL-60 blood cells. [Oral Presentation], Nutrition Society Meeting, Aberdeen, Scotland , 01-JUL-06 - 01-JUL-06. [Details]
(2005)13th Annual Research Day (Faculty of Medicine and Health, UCC),
Lordan S (2005) Comparison of the cytotoxic effects of oxidised low density lipoprotein and oxysterols in human monocytic cells. [Poster Presentation], 13th Annual Research Day (Faculty of Medicine and Health, UCC), Cork, Ireland , 22-JUN-05 - 22-JUN-05. [Details]
(2005)Nutrition Society Postgraduate Meeting,
Lordan S (2005) Oxysterol-induced cell death. [Oral Presentation], Nutrition Society Postgraduate Meeting, Dublin . [Details]
(2005)Nutrition Society Meeting,
Lordan S (2005) An investigation of the anti-apoptotic efficiency of apigenin, astaxanthin and lycopene in cholesterol oxide-treated human monocytic blood cells. [Oral Presentation], Nutrition Society Meeting, Belfast . [Details]

Journal Activities

 JournalRoleTo / From
Cell Biology And Toxicology Referee-
Mar Drugs Referee-
Trends In Food Science And Technology Referee-

Teaching Activities

Teaching Interests

  • Lectured on “Nutrition and Health” as part of Adult Continuing Education night course, University College Cork.  Principal role in course design, development and review.
  • Guest lecturer at the Dept of Biological Sciences, Cork Institute of Technology, as part of the Nutrition and Health Science BSc (Hons) course.

Contact details

  • Sinead Lordan
    ODIN Project Manager
  • s.lordan@ucc.ie
  • School of Food & Nutritional Sciences
    4.09
    Biosciences Institute
    Vitamin D Research Group
    University College Cork
  • 021-4902321

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