Biography

Silvia Melgar research interests lie in mucosal immunology. She received a B.Sc. in Molecular Biology and a Ph.D. in Immunology from Umeå University, Sweden. In 2002, Dr Melgar joined AstraZeneca R&D, Sweden, as a post-doctoral fellow followed by a position as Senior Research Scientist within the disease area of inflammatory bowel diseases. In 2008, she joined the Alimentary Pharmabiotic Centre (APC) at UCC under the GlaxoSmithKline (GSK)-APC collaboration as In vivo Coordinator/Principal scientist. In 2012, she became Senior Research Co-ordinator in the APC and member of the APC faculty. To date Dr Melgar has published 36 full length articles and 5 reviews in the areas of immunology, gastroenterology, pharmacology and microbiology. Her research is funded by the APC and Science Foundation Ireland.

Research Interests

My research interests include -

• To identify novel molecular mechanisms associated to host (immune and non-immune cells) and bacteria interactions and their relevance in health and in intestinal disorders such as inflammatory bowel disease (IBD), colorectal cancer

• To elucidate the contribution of the immune system, environmental stimuli (such as stress and diet) and the microbiota to intestinal health and disease development in experimental models of inflammation and its translation to human diseases.

• Pre-clinical evaluation in animal models and in in vitro systems of novel therapies for inflammatory and malignant conditions of the gastrointestinal tract.

Conference Publications

  Year Publication
(2012) Digestive Disease Week
Ambrose M, Moloney G, Heuston S, Rahman A, Davies JM, Murphy C, Hurley G, Quinlan A, Karras J, Hessel EM, Prinjha R, Lee K, Hyland NP, Shanahan F, Hammarstrom M-L, Melgar S, Nally K (2012) MiR-375 is a Key Regulator of Intestinal Homeostasis in Response to Inflammatory Stress Digestive Disease Week [ Publisher's Version] [Details]
(2011) DDW, Chicago
Moloney G, Fanning A, O’ Malley D, Scanlan N, Melgar S, Nally K (2011) An Altered Immune Profile in IBS Patients? DDW, Chicago [Details]
(2012) DDW 2012; Gastroenterology
Beltran, C.,Fanning, A.,Moloney, G.,Grenham, S.,Heuston, S.,Melgar, S.,Nally, K.,Cryan, J. F.,Dinan, T. G.,Quigley, E. M. (2012) The Role of IL-9/Il9r in Irritable Bowel Syndrome DDW 2012; Gastroenterology [ Publisher's Version] [Details]
(2013) DDW, Orlando 2013
Lindsay J. Hall Carola T. Murphy, Aoife Quinlan, Grainne Hurley, Fergus Shanahan, Kenneth Nally, Silvia Melgar (2013) NK cells protect mice during acute experimental colitis by regulating neutrophil function via NKG2A-dependent mechanisms DDW, Orlando 2013 [Details]
(2014) DDW, Chicago 2014
Darby T, Smith E, Quinlan A, Hurley G, Clarke D, Shanahan F, Nally K, Melgar S. (2014) The colonic adherent-invasive Escherichia coli strain HM605 induces anti-apoptotic responses in intestinal epithelial cells, reduces barrier integrity and worsens experimental colitis DDW, Chicago 2014 [Details]
(2014) DDW, Chicago 2014
O’Mahony C, Clarke SF, Hurley G, O'Sullivan O, Gavin A, Quinlan A, Houston A, Mahmoud A, Bennett MW, Cotter PD, Shanahan F and Melgar S. (2014) High fat feeding alters gut microbiota and protects mice from colitis and colitis-associated colorectal cancer DDW, Chicago 2014 [Details]
(2011) DDW, San Diego 2011
Carola T. Murphy, Lindsay J. Hall, Grainne Hurley, Aoife Quinlan, Fergus Shanahan, Kenneth Nally, Silvia Melgar (2011) The Immunomodulatory Drug FTY720 Prevents Clearance of Citrobacter rodentium Infection in Mice DDW, San Diego 2011 [Details]

Peer Reviewed Journals

  Year Publication
(2012) 'Modelling of Mouse Experimental Colitis by Global Property Screens: A Holistic Approach to Assess Drug Effects in Inflammatory Bowel Disease'
Gottfries, J,Melgar, S,Michaelsson, E (2012) 'Modelling of Mouse Experimental Colitis by Global Property Screens: A Holistic Approach to Assess Drug Effects in Inflammatory Bowel Disease'. Plos One, 7 [DOI] [Details]
(2010) 'Technical Advance: Function and efficacy of an alpha(4)-integrin antagonist using bioluminescence imaging to detect leukocyte trafficking in murine experimental colitis'
Murphy, CT,Moloney, G,MacSharry, J,Haynes, A,Faivre, E,Quinlan, A,McLean, PG,Lee, K,O'Mahony, L,Shanahan, F,Melgar, S,Nally, K (2010) 'Technical Advance: Function and efficacy of an alpha(4)-integrin antagonist using bioluminescence imaging to detect leukocyte trafficking in murine experimental colitis'. Journal of Leukocyte Biology, 88 :1271-1278 [DOI] [Details]
(2010) 'IL-1 Receptor-associated Kinase M Downregulates DSS-induced Colitis'
Berglund, M,Melgar, S,Kobayashi, KS,Flavell, RA,Hornquist, EH,Hultgren, OH; (2010) 'IL-1 Receptor-associated Kinase M Downregulates DSS-induced Colitis'. Inflammatory Bowel Diseases, 16 :1778-1786 [DOI] [Details]
(2009) 'Gender Dependent Importance of Irak-1 In Dextran Sulfate Sodium Induced Colitis'
Berglund, M, Thomas, JA, Fredin, MF, Melgar, S, Hornquist, EH, Hultgren, OH; (2009) 'Gender Dependent Importance of Irak-1 In Dextran Sulfate Sodium Induced Colitis'. Cellular Immunology, 259 (1):27-32 [DOI] [Details]
(2008) 'The application and relevance of ex vivo culture systems for assessment of IBD treatment in murine models of colitis'
Fritsch Fredin M, Vidal A, Utkovic H, Götlind YY, Willén R, Jansson L, Hultgren Hörnquist E, Melgar S. (2008) 'The application and relevance of ex vivo culture systems for assessment of IBD treatment in murine models of colitis'. Pharmacological Research, 58 (3-4):222-231 [Details]
(2008) 'Intra-colonic administration of the TLR7 agonist R-848 induces an acute local and systemic inflammation in mice'
Karlsson, A,Jagervall, A,Utkovic, H,Karlsson, L,Rehnstrom, E,Fredin, MF,Gillberg, PG,Jansson, L,Michaelsson, E,Melgar, S; (2008) 'Intra-colonic administration of the TLR7 agonist R-848 induces an acute local and systemic inflammation in mice'. Biochemical and Biophysical Research Communications, 367 :242-248 [DOI] [Details]
(2007) 'Mice with experimental colitis show an altered metabolism with decreased metabolic rate'
Melgar S, Bjursell M, Gerdin AK, Svensson L, Michaëlsson E, Bohlooly-Y M. (2007) 'Mice with experimental colitis show an altered metabolism with decreased metabolic rate'. American Journal of Physiology - Gastrointestinal and Liver Physiology, 292 (1):G165-172 [Details]
(2006) 'Magnetic resonance imaging of experimental mouse colitis and association with inflammatory activity'
Larsson AE, Melgar S, Rehnström E, Michaëlsson E, Svensson L, Hockings P, Olsson LE. (2006) 'Magnetic resonance imaging of experimental mouse colitis and association with inflammatory activity'. Inflammatory Bowel Diseases, 12 (6):478-485 [Details]
(2005) 'Acute colitis induced by dextran sulfate sodium progresses to chronicity in C57BL/6 but not in BALB/c mice: correlation between symptoms and inflammation'
Melgar S, Karlsson A, Michaëlsson E. (2005) 'Acute colitis induced by dextran sulfate sodium progresses to chronicity in C57BL/6 but not in BALB/c mice: correlation between symptoms and inflammation'. American Journal of Physiology - Gastrointestinal and Liver Physiology, 288 (6):G1328-1338 [Details]
(2003) 'Over-expression of interleukin 10 in mucosal T cells of patients with active ulcerative colitis'
Melgar S, Yeung MM, Bas A, Forsberg G, Suhr O, Oberg A, Hammarstrom S, Danielsson A, Hammarstrom ML. (2003) 'Over-expression of interleukin 10 in mucosal T cells of patients with active ulcerative colitis'. Clinical and Experimental Immunology, 134 (1):127-137 [Details]
(2002) 'Paradoxical coexpression of proinflammatory and down-regulatory cytokines in intestinal T cells in childhood celiac disease'
Forsberg G, Hernell O, Melgar S, Israelsson A, Hammarström S, Hammarström ML. (2002) 'Paradoxical coexpression of proinflammatory and down-regulatory cytokines in intestinal T cells in childhood celiac disease'. Gastroenterology, 123 (3):667-678 [Details]
(2000) 'Characterisation of mucosal lymphoid aggregates in ulcerative colitis: immune cell phenotype and TcR-gammadelta expression'
Yeung MM, Melgar S, Baranov V, Oberg A, Danielsson A, Hammarström S, Hammarström ML. (2000) 'Characterisation of mucosal lymphoid aggregates in ulcerative colitis: immune cell phenotype and TcR-gammadelta expression'. Gut, 47 (2):215-227 [Details]
(1999) 'An apoptotic response by J774 macrophage cells is common upon infection with diarrheagenic Escherichia coli'
Lai XH, Xu JG, Melgar S, Uhlin BE. (1999) 'An apoptotic response by J774 macrophage cells is common upon infection with diarrheagenic Escherichia coli'. Fems Microbiology Letters, [Details]
(1996) 'Intraepithelial lymphocytes in human gut have lytic potential and a cytokine profile that suggest T helper 1 and cytotoxic functions'
Lindqvist C, Melgar S, Yeung MM, Hammarström S, Hammarström ML. (1996) 'Intraepithelial lymphocytes in human gut have lytic potential and a cytokine profile that suggest T helper 1 and cytotoxic functions'. Journal of Immunology, 157 (5):1926-1934 [Details]
(2013) 'Bcl-deficiency protects against dextran-sodium sulphate-induced colitis in the mouse'
O'Carroll, C.,Moloney, G.,Hurley, G.,Melgar, S.,Brint, E.,Nally, K.,Nibbs, R. J.,Shanahan, F.,Carmody, R. J. (2013) 'Bcl-deficiency protects against dextran-sodium sulphate-induced colitis in the mouse'. Clin Exp Immunol, 173 (22):332-342332 [ Publisher's Version] [Details]
(2013) 'Natural killer cells protect mice from DSS-induced colitis by regulating neutrophil function via the NKG2A receptor'
Hall LJ, Murphy CT, Quinlan A, Hurley G, Shanahan F, Nally K, Melgar S (2013) 'Natural killer cells protect mice from DSS-induced colitis by regulating neutrophil function via the NKG2A receptor'. Mucosal immunology, [DOI] [Details]
(2008) 'Psychological stress reactivates dextran sulfate sodium-induced chronic colitis in mice'
Melgar S, Engström K, Jägervall A, Martinez V. (2008) 'Psychological stress reactivates dextran sulfate sodium-induced chronic colitis in mice'. Stress (Amsterdam, Netherlands), 11 (5) [Details]
(2008) 'Validation of murine dextran sulfate sodium-induced colitis using four therapeutic agents for human inflammatory bowel disease'
Melgar S, Karlsson L, Rehnström E, Karlsson A, Utkovic H, Jansson L, Michaëlsson E. (2008) 'Validation of murine dextran sulfate sodium-induced colitis using four therapeutic agents for human inflammatory bowel disease'. International immunopharmacology, 8 (6) [Details]
(2008) 'Predicting and monitoring colitis development in mice by micro-computed tomography'
Fredin MF, Hultin L, Hyberg G, Rehnström E, Hultgren Hörnquist E, Melgar S, Jansson L. (2008) 'Predicting and monitoring colitis development in mice by micro-computed tomography'. Inflammatory Bowel Diseases, 14 (4) [Details]
(2004) 'Cytolytic capabilities of lamina propria and intraepithelial lymphocytes in normal and chronically inflamed human intestine'
Melgar S, Hammarström S, Oberg A, Danielsson A, Hammarström ML. (2004) 'Cytolytic capabilities of lamina propria and intraepithelial lymphocytes in normal and chronically inflamed human intestine'. [Details]
(2012) 'Mechanism of protection of transepithelial barrier function by Lactobacillus salivarius: strain dependence and attenuation by bacteriocin production'
Miyauchi, E.,O'Callaghan, J.,Butto, L. F.,Hurley, G.,Melgar, S.,Tanabe, S.,Shanahan, F.,Nally, K.,O'Toole, P. W. (2012) 'Mechanism of protection of transepithelial barrier function by Lactobacillus salivarius: strain dependence and attenuation by bacteriocin production'. American Journal of Physiology-Gastrointestinal and Liver Physiology, 303 (99) [ Publisher's Version] [Details]
(2011) 'Induction and Activation of Adaptive Immune Populations During Acute and Chronic Phases of a Murine Model of Experimental Colitis'
Hall, L. J.,Faivre, E.,Quinlan, A.,Shanahan, F.,Nally, K.,Melgar, S. (2011) 'Induction and Activation of Adaptive Immune Populations During Acute and Chronic Phases of a Murine Model of Experimental Colitis'. Dig Dis Sci, 56 (11):79-8979 [ Publisher's Version] [Details]
(2010) 'Use of bioluminescence imaging to track neutrophil migration and its inhibition in experimental colitis'
Murphy, C. T.,Moloney, G.,Hall, L. J.,Quinlan, A.,Faivre, E.,Casey, P.,Shanahan, F.,Melgar, S.,Nally, K. (2010) 'Use of bioluminescence imaging to track neutrophil migration and its inhibition in experimental colitis'. Clin Exp Immunol, 162 (11):188-196188 [ Publisher's Version] [Details]
(2012) 'The Sphingosine-1-Phosphate Analogue FTY720 Impairs Mucosal Immunity and Clearance of the Enteric Pathogen Citrobacter rodentium'
Murphy, C. T.,Hall, L. J.,Hurley, G.,Quinlan, A.,MacSharry, J.,Shanahan, F.,Nally, K.,Melgar, S. (2012) 'The Sphingosine-1-Phosphate Analogue FTY720 Impairs Mucosal Immunity and Clearance of the Enteric Pathogen Citrobacter rodentium'. Infect Immun, 80 (88):2712-27232712 [ Publisher's Version] [Details]
(2014) 'Activation of liver X receptor suppresses the production of the IL-12 family of cytokines by blocking nuclear translocation of NF-kappa Bp50'
Canavan, M,McCarthy, C,Ben Larbi, N,Dowling, JK,Collins, L,O'Sullivan, F,Hurley, G,Murphy, C,Quinlan, A,Moloney, G,Darby, T,MacSharry, J,Kagechika, H,Moynagh, P,Melgar, S,Loscher, CE (2014) 'Activation of liver X receptor suppresses the production of the IL-12 family of cytokines by blocking nuclear translocation of NF-kappa Bp50'. Innate Immunity, 20 :675-687 [DOI] [Details]
(2013) 'Natural Killer Cells Protect against Mucosal and Systemic Infection with the Enteric Pathogen Citrobacter rodentium'
Hall, LJ,Murphy, CT,Hurley, G,Quinlan, A,Shanahan, F,Nally, K,Melgar, S (2013) 'Natural Killer Cells Protect against Mucosal and Systemic Infection with the Enteric Pathogen Citrobacter rodentium'. Infection and Immunity, 81 :460-469 [DOI] [Details]
(2008) 'Predicting and monitoring colitis development in mice by Micro-Computed Tomography'
Fritsch Fredin M, Hultin L, Hyberg G, Hultgren Hörnquist E, Melgar S, Jansson L (2008) 'Predicting and monitoring colitis development in mice by Micro-Computed Tomography'. Inflammatory Bowel Diseases, 14 (4):491-499 [Details]
(2008) 'Lack of visceral-inflammation in Nav1.9 KO mice'
Martinez V and Melgar S (2008) 'Lack of visceral-inflammation in Nav1.9 KO mice'. European Journal of Pain, 12 (7):934-944 [Details]
(2007) '“Dextran sulfate sodium induced colitis generates a transient thymic involution - impact on thymocyte subsets'
Fritsch MF, Elgbratt K, Svensson D, Jansson L, Melgar S, Hultgren-Hörnquist E. (2007) '“Dextran sulfate sodium induced colitis generates a transient thymic involution - impact on thymocyte subsets'. Scandinavian journal of infectious diseases. Supplementum, [Details]
(2013) 'Gene silencing of TNF-alpha in a murine model of acute colitis using a modified cyclodextrin delivery system'
McCarthy, J,O'Neill, MJ,Bourre, L,Walsh, D,Quinlan, A,Hurley, G,Ogier, J,Shanahan, F,Melgar, S,Darcy, R,O'Driscoll, CM (2013) 'Gene silencing of TNF-alpha in a murine model of acute colitis using a modified cyclodextrin delivery system'. Journal of controlled release : official journal of the Controlled Release Society, 168 :28-34 [DOI] [Details]
(2008) '“Dextran sodium sulphate induces acute colitis and alters hepatic function in hamsters”'
Karlsson A, Jägervall Å, Pettersson M, Andersson A-K, Gillberg P-G, Melgar S. (2008) '“Dextran sodium sulphate induces acute colitis and alters hepatic function in hamsters”'. International immunopharmacology, 8 :20-27 [Details]
(2008) '“High throughput magnetic resonance imaging in murine colonic inflammation”'
Melgar S, Gillberg P-G, Hockings PD, and Olsson LE. (2008) '“High throughput magnetic resonance imaging in murine colonic inflammation”'. Biochemical Biophysical Research Communications, 355 :1102-1107 [Details]
(2000) 'Neuroendocrine changes in colon of mice with a disrupted IL-2 gene'
Qian BF, El-Salhy M, Melgar S, Hammarstrom ML, Danielsson A (2000) 'Neuroendocrine changes in colon of mice with a disrupted IL-2 gene'. Clinical and Experimental Immunology, 120 (3):424-433 [Details]
(2006) '“Local production of chemokines and prostaglandin E2 in the acute, chronic and recovery phase of murine experimental colitis'
Melgar S, Drmotova M, Rehnström E, Jansson L, Michaёlsson E. (2006) '“Local production of chemokines and prostaglandin E2 in the acute, chronic and recovery phase of murine experimental colitis'. Cytokine, [Details]
(2014) 'Effects of anti-inflammatory therapy on bursting pressure of colonic anastomosis in murine dextran sulfate sodium induced colitis'
Myrelid P, Salim S, Darby T, Melgar S, Andersson P, Söderholm JD (2014) 'Effects of anti-inflammatory therapy on bursting pressure of colonic anastomosis in murine dextran sulfate sodium induced colitis'. Scandinavian Journal of Gastroenterology, [Details]
(2013) 'Pellino3 ubiquitinates RIP2 and mediates Nod2-induced signaling and protective effects in colitis'
Yang, S,Wang, BW,Humphries, F,Jackson, R,Healy, ME,Bergin, R,Aviello, G,Hall, B,McNamara, D,Darby, T,Quinlan, A,Shanahan, F,Melgar, S,Fallon, PG,Moynagh, PN (2013) 'Pellino3 ubiquitinates RIP2 and mediates Nod2-induced signaling and protective effects in colitis'. Nature immunology, 14 [DOI] [Details]

Review Articles

  Year Publication
(2012) Pattern recognition receptors-Molecular orchestrators of inflammation in inflammatory bowel disease.
Walsh D, McCarthy J, O'Driscoll C, Melgar S. (2012) Pattern recognition receptors-Molecular orchestrators of inflammation in inflammatory bowel disease. http://www.sciencedirect.com/science/article/pii/S1359610112000779: Review Articles [Details]
(2012) Shining a Light on Intestinal Traffic.
Murphy, CT,Nally, K,Shanahan, F,Melgar, S (2012) Shining a Light on Intestinal Traffic. Review Articles [DOI] [Details]
(2011) Intestinal delivery of non-viral gene therapeutics: physiological barriers and preclinical models.
O'Neill, MJ,Bourre, L,Melgar, S,O'Driscoll, CM (2011) Intestinal delivery of non-viral gene therapeutics: physiological barriers and preclinical models. Review Articles [DOI] [Details]
(2010) Inflammatory bowel disease-From mechanisms to treatment strategies.
Melgar, S,Shanahan, F (2010) Inflammatory bowel disease-From mechanisms to treatment strategies. Review Articles [DOI] [Details]
(2014) The complex role of inflammasomes in the pathogenesis of Inflammatory Bowel Diseases - Lessons learned from experimental models”.
Aguilera M, Darby T, Melgar S (2014) The complex role of inflammasomes in the pathogenesis of Inflammatory Bowel Diseases - Lessons learned from experimental models”. Review Articles [Details]

Honours and Awards

  Year Title Awarding Body
2001 Travel Award Umea University-Washington University Scientific exchange programme
2000 Travel Award JC Kempes Akademiska fond and JC Kempes Minnes Akademiska Forsknings fond, Umea, Sweden
1999 Travel Award Medical Facultity, Umea University, Sweden
2001 Travel Award Medical Faculty, Umea University, Sweden

Professional Associations

  Association Function From / To
American Gastroenterology Association Member /
Society of Mucosal Immunology Member /
European Crohn's and Colitis Organisation Member /

Committees

  Committee Function From / To
PhD Examinor Ms.Caitlin O’Mahony Internal Examinor 2009 /
PhD Examiner Juan F. Burgueno Banus PhD Examiner 2014 / 2014

Employment

  Employer Position From / To
AstraZeneca R&D Molndal, Sweden Post-doctoral Fellow 01-FEB-02 / 31-MAY-05
AstraZeneca R&D Molndal, Sweden Senior Research Scientist 01-JUN-06 / 31-DEC-07
GlaxoSmithKline, Cork Principal Scientist 07-JAN-08 / 20-JAN-12

Education

  Year Institution Qualification Subject
1995 Umea Univerisity, Sweden BSC Molecular Biology
2002 Umea University, Sweden PHD I NIMMUNOLOGY Immunology

Languages

  Language Reading Writing Speaking
French Basic Basic Basic
English Fluent Fluent Fluent
Swedish Fluent Fluent Fluent
Spanish Fluent Fluent Fluent

Journal Activities

  Journal Role To / From
Journal Of Dairy Research Referee -
Expert Opinion On Investigational Drugs Referee -
Physiology And Behaviour Referee -
Journal Of Gene Medicine Referee -
Life Sciences Referee -
Journal Of Biomedicine And Biotechnology Referee -
Digestive Diseases And Sciences Referee -
Gastroenterology Referee -
British Journal Of Pharmacology Referee -
Molecular Medicine Referee -
Autophagy Referee -
Gut Referee -
J Immunol Referee -
Bmc Gastroenterol Referee -
J Crohns Colitis Referee -

Other Activities

  Description

Reviewer for grant application from "The Israel Science Foundation (ISF)"

Reviewer assigment for grant applications for “The Broad Medical Research Program, IBD Grants, The Eli and Edythe L. Broad Foundation”

Recent Postgraduates

  Graduation Year Student Name Institution Degree Type Thesis Title
2014 Jerzy Woznicki University College Cork PHD Molecular mechanisms underpinning IFN-g and TNF-a synergy in intestinal epithelial cells
2014 Trevor Darby University College Cork PHD Molecular analysis of inflammatory mechanisms associated with Escherichia coli and Inflammatory Bowel Diseases
2012 Carola T Murphy University College Cork PHD Investigation of the mechanisms underpinning leukocyte trafficking in animal models of intestinal inflammation
2014 Ruth Bourke University College Cork MSc Molecular analysis of macrophage and adipocyte responses in mice fed high fat diet and its contribution to experimental colitis progression
2014 Leanne O’ Riordan University College Cork MSc Bioinformatics Translational analysis of fecal microbiota composition in animal models of colitis to Inflammatory Bowel Disease patients
2014 Siobhan McDonnell University College Cork MSc An Analysis of the Immune Responses Provoked by Crohn’s Disease Associated Adherent Invasive Escherichia coli in Intestinal Epithelial Cells

Current Postgraduate Students

  Student Degree Type Primary
Barrett Kevin Paul Masters Degree by Research No

Internal Collaborators

  Name Institute Country
Prof Caitriona O'Driscoll School of Pharmacy IRELAND
Dr. Paul Cotter Teagasc Moorepark IRELAND
Dr Justin McCarthy Dept of Biochemistry IRELAND
Prof. Dmitri Papkovsky Dept of Biochemistry IRELAND
Dr Susan Joyce School of Medicine IRELAND
Dr Ken Nally Dept of Biochemistry IRELAND
Dr David Clarke Microbiology IRELAND

External Collaborators

  Name Organisation/ Institution Country
Dr Christine Loscher Dublin City Univeristy IRELAND
Prof Paul Moynagh National University of Ireland Maynooth IRELAND
Prof Marie-Louise Hammarstrom Umea University SWEDEN
Dr Ken Cadwell NYU U.S.A.
Prof Johan D Soderholm Linkoping University SWEDEN
Dr Ed Lavell Trinity College Dublin IRELAND