• To identify novel molecular mechanisms associated to host (immune and non-immune cells) and bacteria interactions and their relevance in health and in intestinal disorders such as inflammatory bowel disease (IBD), colorectal cancer
Biography
Silvia Melgar research interests lie in mucosal immunology. She received a B.Sc. in Molecular Biology and a Ph.D. in Immunology from Umeå University, Sweden. In 2002, Dr Melgar joined AstraZeneca R&D, Sweden, as a post-doctoral fellow followed by a position as Senior Research Scientist within the disease area of inflammatory bowel diseases. In 2008, she joined the Alimentary Pharmabiotic Centre (APC) at UCC under the GlaxoSmithKline (GSK)-APC collaboration as In vivo Coordinator/Principal scientist. In 2012, she became Senior Research Co-ordinator in the APC and member of the APC faculty. To date Dr Melgar has published 36 full length articles and 5 reviews in the areas of immunology, gastroenterology, pharmacology and microbiology. Her research is funded by the APC and Science Foundation Ireland.
Research Interests
My research interests include -• To identify novel molecular mechanisms associated to host (immune and non-immune cells) and bacteria interactions and their relevance in health and in intestinal disorders such as inflammatory bowel disease (IBD), colorectal cancer
• To elucidate the contribution of the immune system, environmental stimuli (such as stress and diet) and the microbiota to intestinal health and disease development in experimental models of inflammation and its translation to human diseases.
• Pre-clinical evaluation in animal models and in in vitro systems of novel therapies for inflammatory and malignant conditions of the gastrointestinal tract.
Publications
Conference Publications
| Year | Publication | |
|---|---|---|
| (2012) | Digestive Disease Week Ambrose M, Moloney G, Heuston S, Rahman A, Davies JM, Murphy C, Hurley G, Quinlan A, Karras J, Hessel EM, Prinjha R, Lee K, Hyland NP, Shanahan F, Hammarstrom M-L, Melgar S, Nally K (2012) MiR-375 is a Key Regulator of Intestinal Homeostasis in Response to Inflammatory Stress Digestive Disease Week [Details] | |
| (2011) | DDW, Chicago Moloney G, Fanning A, O’ Malley D, Scanlan N, Melgar S, Nally K (2011) An Altered Immune Profile in IBS Patients? DDW, Chicago [Details] | |
| (2012) | DDW 2012; Gastroenterology Beltran, C.,Fanning, A.,Moloney, G.,Grenham, S.,Heuston, S.,Melgar, S.,Nally, K.,Cryan, J. F.,Dinan, T. G.,Quigley, E. M. (2012) The Role of IL-9/Il9r in Irritable Bowel Syndrome DDW 2012; Gastroenterology [Details] | |
| (2013) | DDW, Orlando 2013 Lindsay J. Hall Carola T. Murphy, Aoife Quinlan, Grainne Hurley, Fergus Shanahan, Kenneth Nally, Silvia Melgar (2013) NK cells protect mice during acute experimental colitis by regulating neutrophil function via NKG2A-dependent mechanisms DDW, Orlando 2013 [Details] | |
| (2014) | DDW, Chicago 2014 Darby T, Smith E, Quinlan A, Hurley G, Clarke D, Shanahan F, Nally K, Melgar S. (2014) The colonic adherent-invasive Escherichia coli strain HM605 induces anti-apoptotic responses in intestinal epithelial cells, reduces barrier integrity and worsens experimental colitis DDW, Chicago 2014 [Details] | |
| (2014) | DDW, Chicago 2014 O’Mahony C, Clarke SF, Hurley G, O'Sullivan O, Gavin A, Quinlan A, Houston A, Mahmoud A, Bennett MW, Cotter PD, Shanahan F and Melgar S. (2014) High fat feeding alters gut microbiota and protects mice from colitis and colitis-associated colorectal cancer DDW, Chicago 2014 [Details] | |
| (2011) | DDW, San Diego 2011 Carola T. Murphy, Lindsay J. Hall, Grainne Hurley, Aoife Quinlan, Fergus Shanahan, Kenneth Nally, Silvia Melgar (2011) The Immunomodulatory Drug FTY720 Prevents Clearance of Citrobacter rodentium Infection in Mice DDW, San Diego 2011 [Details] |
Peer Reviewed Journals
| Year | Publication | |
|---|---|---|
| (2012) | 'Modelling of Mouse Experimental Colitis by Global Property Screens: A Holistic Approach to Assess Drug Effects in Inflammatory Bowel Disease' Gottfries, J,Melgar, S,Michaelsson, E (2012) 'Modelling of Mouse Experimental Colitis by Global Property Screens: A Holistic Approach to Assess Drug Effects in Inflammatory Bowel Disease'. Plos One, 7 [DOI] [Details] | |
| (2010) | 'Technical Advance: Function and efficacy of an alpha(4)-integrin antagonist using bioluminescence imaging to detect leukocyte trafficking in murine experimental colitis' Murphy, CT,Moloney, G,MacSharry, J,Haynes, A,Faivre, E,Quinlan, A,McLean, PG,Lee, K,O'Mahony, L,Shanahan, F,Melgar, S,Nally, K (2010) 'Technical Advance: Function and efficacy of an alpha(4)-integrin antagonist using bioluminescence imaging to detect leukocyte trafficking in murine experimental colitis'. Journal of Leukocyte Biology, 88 :1271-1278 [DOI] [Details] | |
| (2010) | 'IL-1 Receptor-associated Kinase M Downregulates DSS-induced Colitis' Berglund, M,Melgar, S,Kobayashi, KS,Flavell, RA,Hornquist, EH,Hultgren, OH; (2010) 'IL-1 Receptor-associated Kinase M Downregulates DSS-induced Colitis'. Inflammatory Bowel Diseases, 16 :1778-1786 [DOI] [Details] | |
| (2009) | 'Gender Dependent Importance of Irak-1 In Dextran Sulfate Sodium Induced Colitis' Berglund, M, Thomas, JA, Fredin, MF, Melgar, S, Hornquist, EH, Hultgren, OH; (2009) 'Gender Dependent Importance of Irak-1 In Dextran Sulfate Sodium Induced Colitis'. Cellular Immunology, 259 (1):27-32 [DOI] [Details] | |
| (2008) | 'The application and relevance of ex vivo culture systems for assessment of IBD treatment in murine models of colitis' Fritsch Fredin M, Vidal A, Utkovic H, Götlind YY, Willén R, Jansson L, Hultgren Hörnquist E, Melgar S. (2008) 'The application and relevance of ex vivo culture systems for assessment of IBD treatment in murine models of colitis'. Pharmacological Research, 58 (3-4):222-231 [Details] | |
| (2008) | 'Intra-colonic administration of the TLR7 agonist R-848 induces an acute local and systemic inflammation in mice' Karlsson, A,Jagervall, A,Utkovic, H,Karlsson, L,Rehnstrom, E,Fredin, MF,Gillberg, PG,Jansson, L,Michaelsson, E,Melgar, S; (2008) 'Intra-colonic administration of the TLR7 agonist R-848 induces an acute local and systemic inflammation in mice'. Biochemical and Biophysical Research Communications, 367 :242-248 [DOI] [Details] | |
| (2007) | 'Mice with experimental colitis show an altered metabolism with decreased metabolic rate' Melgar S, Bjursell M, Gerdin AK, Svensson L, Michaëlsson E, Bohlooly-Y M. (2007) 'Mice with experimental colitis show an altered metabolism with decreased metabolic rate'. American Journal of Physiology - Gastrointestinal and Liver Physiology, 292 (1):G165-172 [Details] | |
| (2006) | 'Magnetic resonance imaging of experimental mouse colitis and association with inflammatory activity' Larsson AE, Melgar S, Rehnström E, Michaëlsson E, Svensson L, Hockings P, Olsson LE. (2006) 'Magnetic resonance imaging of experimental mouse colitis and association with inflammatory activity'. Inflammatory Bowel Diseases, 12 (6):478-485 [Details] | |
| (2005) | 'Acute colitis induced by dextran sulfate sodium progresses to chronicity in C57BL/6 but not in BALB/c mice: correlation between symptoms and inflammation' Melgar S, Karlsson A, Michaëlsson E. (2005) 'Acute colitis induced by dextran sulfate sodium progresses to chronicity in C57BL/6 but not in BALB/c mice: correlation between symptoms and inflammation'. American Journal of Physiology - Gastrointestinal and Liver Physiology, 288 (6):G1328-1338 [Details] | |
| (2003) | 'Over-expression of interleukin 10 in mucosal T cells of patients with active ulcerative colitis' Melgar S, Yeung MM, Bas A, Forsberg G, Suhr O, Oberg A, Hammarstrom S, Danielsson A, Hammarstrom ML. (2003) 'Over-expression of interleukin 10 in mucosal T cells of patients with active ulcerative colitis'. Clinical and Experimental Immunology, 134 (1):127-137 [Details] | |
| (2002) | 'Paradoxical coexpression of proinflammatory and down-regulatory cytokines in intestinal T cells in childhood celiac disease' Forsberg G, Hernell O, Melgar S, Israelsson A, Hammarström S, Hammarström ML. (2002) 'Paradoxical coexpression of proinflammatory and down-regulatory cytokines in intestinal T cells in childhood celiac disease'. Gastroenterology, 123 (3):667-678 [Details] | |
| (2000) | 'Characterisation of mucosal lymphoid aggregates in ulcerative colitis: immune cell phenotype and TcR-gammadelta expression' Yeung MM, Melgar S, Baranov V, Oberg A, Danielsson A, Hammarström S, Hammarström ML. (2000) 'Characterisation of mucosal lymphoid aggregates in ulcerative colitis: immune cell phenotype and TcR-gammadelta expression'. Gut, 47 (2):215-227 [Details] | |
| (1999) | 'An apoptotic response by J774 macrophage cells is common upon infection with diarrheagenic Escherichia coli' Lai XH, Xu JG, Melgar S, Uhlin BE. (1999) 'An apoptotic response by J774 macrophage cells is common upon infection with diarrheagenic Escherichia coli'. Fems Microbiology Letters, [Details] | |
| (1996) | 'Intraepithelial lymphocytes in human gut have lytic potential and a cytokine profile that suggest T helper 1 and cytotoxic functions' Lindqvist C, Melgar S, Yeung MM, Hammarström S, Hammarström ML. (1996) 'Intraepithelial lymphocytes in human gut have lytic potential and a cytokine profile that suggest T helper 1 and cytotoxic functions'. Journal of Immunology, 157 (5):1926-1934 [Details] | |
| (2013) | 'Bcl-deficiency protects against dextran-sodium sulphate-induced colitis in the mouse' O'Carroll, C.,Moloney, G.,Hurley, G.,Melgar, S.,Brint, E.,Nally, K.,Nibbs, R. J.,Shanahan, F.,Carmody, R. J. (2013) 'Bcl-deficiency protects against dextran-sodium sulphate-induced colitis in the mouse'. Clin Exp Immunol, 173 (22):332-342332 [Details] | |
| (2013) | 'Natural killer cells protect mice from DSS-induced colitis by regulating neutrophil function via the NKG2A receptor' Hall LJ, Murphy CT, Quinlan A, Hurley G, Shanahan F, Nally K, Melgar S (2013) 'Natural killer cells protect mice from DSS-induced colitis by regulating neutrophil function via the NKG2A receptor'. Mucosal immunology, [DOI] [Details] | |
| (2008) | 'Psychological stress reactivates dextran sulfate sodium-induced chronic colitis in mice' Melgar S, Engström K, Jägervall A, Martinez V. (2008) 'Psychological stress reactivates dextran sulfate sodium-induced chronic colitis in mice'. Stress (Amsterdam, Netherlands), 11 (5) [Details] | |
| (2008) | 'Validation of murine dextran sulfate sodium-induced colitis using four therapeutic agents for human inflammatory bowel disease' Melgar S, Karlsson L, Rehnström E, Karlsson A, Utkovic H, Jansson L, Michaëlsson E. (2008) 'Validation of murine dextran sulfate sodium-induced colitis using four therapeutic agents for human inflammatory bowel disease'. International immunopharmacology, 8 (6) [Details] | |
| (2008) | 'Predicting and monitoring colitis development in mice by micro-computed tomography' Fredin MF, Hultin L, Hyberg G, Rehnström E, Hultgren Hörnquist E, Melgar S, Jansson L. (2008) 'Predicting and monitoring colitis development in mice by micro-computed tomography'. Inflammatory Bowel Diseases, 14 (4) [Details] | |
| (2004) | 'Cytolytic capabilities of lamina propria and intraepithelial lymphocytes in normal and chronically inflamed human intestine' Melgar S, Hammarström S, Oberg A, Danielsson A, Hammarström ML. (2004) 'Cytolytic capabilities of lamina propria and intraepithelial lymphocytes in normal and chronically inflamed human intestine'. [Details] | |
| (2012) | 'Mechanism of protection of transepithelial barrier function by Lactobacillus salivarius: strain dependence and attenuation by bacteriocin production' Miyauchi, E.,O'Callaghan, J.,Butto, L. F.,Hurley, G.,Melgar, S.,Tanabe, S.,Shanahan, F.,Nally, K.,O'Toole, P. W. (2012) 'Mechanism of protection of transepithelial barrier function by Lactobacillus salivarius: strain dependence and attenuation by bacteriocin production'. American Journal of Physiology-Gastrointestinal and Liver Physiology, 303 (99) [Details] | |
| (2011) | 'Induction and Activation of Adaptive Immune Populations During Acute and Chronic Phases of a Murine Model of Experimental Colitis' Hall, L. J.,Faivre, E.,Quinlan, A.,Shanahan, F.,Nally, K.,Melgar, S. (2011) 'Induction and Activation of Adaptive Immune Populations During Acute and Chronic Phases of a Murine Model of Experimental Colitis'. Dig Dis Sci, 56 (11):79-8979 [Details] | |
| (2010) | 'Use of bioluminescence imaging to track neutrophil migration and its inhibition in experimental colitis' Murphy, C. T.,Moloney, G.,Hall, L. J.,Quinlan, A.,Faivre, E.,Casey, P.,Shanahan, F.,Melgar, S.,Nally, K. (2010) 'Use of bioluminescence imaging to track neutrophil migration and its inhibition in experimental colitis'. Clin Exp Immunol, 162 (11):188-196188 [Details] | |
| (2012) | 'The Sphingosine-1-Phosphate Analogue FTY720 Impairs Mucosal Immunity and Clearance of the Enteric Pathogen Citrobacter rodentium' Murphy, C. T.,Hall, L. J.,Hurley, G.,Quinlan, A.,MacSharry, J.,Shanahan, F.,Nally, K.,Melgar, S. (2012) 'The Sphingosine-1-Phosphate Analogue FTY720 Impairs Mucosal Immunity and Clearance of the Enteric Pathogen Citrobacter rodentium'. Infect Immun, 80 (88):2712-27232712 [Details] | |
| (2014) | 'Activation of liver X receptor suppresses the production of the IL-12 family of cytokines by blocking nuclear translocation of NF-kappa Bp50' Canavan, M,McCarthy, C,Ben Larbi, N,Dowling, JK,Collins, L,O'Sullivan, F,Hurley, G,Murphy, C,Quinlan, A,Moloney, G,Darby, T,MacSharry, J,Kagechika, H,Moynagh, P,Melgar, S,Loscher, CE (2014) 'Activation of liver X receptor suppresses the production of the IL-12 family of cytokines by blocking nuclear translocation of NF-kappa Bp50'. Innate Immunity, 20 :675-687 [DOI] [Details] | |
| (2013) | 'Natural Killer Cells Protect against Mucosal and Systemic Infection with the Enteric Pathogen Citrobacter rodentium' Hall, LJ,Murphy, CT,Hurley, G,Quinlan, A,Shanahan, F,Nally, K,Melgar, S (2013) 'Natural Killer Cells Protect against Mucosal and Systemic Infection with the Enteric Pathogen Citrobacter rodentium'. Infection and Immunity, 81 :460-469 [DOI] [Details] | |
| (2008) | 'Predicting and monitoring colitis development in mice by Micro-Computed Tomography' Fritsch Fredin M, Hultin L, Hyberg G, Hultgren Hörnquist E, Melgar S, Jansson L (2008) 'Predicting and monitoring colitis development in mice by Micro-Computed Tomography'. Inflammatory Bowel Diseases, 14 (4):491-499 [Details] | |
| (2008) | 'Lack of visceral-inflammation in Nav1.9 KO mice' Martinez V and Melgar S (2008) 'Lack of visceral-inflammation in Nav1.9 KO mice'. European Journal of Pain, 12 (7):934-944 [Details] | |
| (2007) | '“Dextran sulfate sodium induced colitis generates a transient thymic involution - impact on thymocyte subsets' Fritsch MF, Elgbratt K, Svensson D, Jansson L, Melgar S, Hultgren-Hörnquist E. (2007) '“Dextran sulfate sodium induced colitis generates a transient thymic involution - impact on thymocyte subsets'. Scandinavian journal of infectious diseases. Supplementum, [Details] | |
| (2013) | 'Gene silencing of TNF-alpha in a murine model of acute colitis using a modified cyclodextrin delivery system' McCarthy, J,O'Neill, MJ,Bourre, L,Walsh, D,Quinlan, A,Hurley, G,Ogier, J,Shanahan, F,Melgar, S,Darcy, R,O'Driscoll, CM (2013) 'Gene silencing of TNF-alpha in a murine model of acute colitis using a modified cyclodextrin delivery system'. Journal of controlled release : official journal of the Controlled Release Society, 168 :28-34 [DOI] [Details] | |
| (2008) | '“Dextran sodium sulphate induces acute colitis and alters hepatic function in hamsters”' Karlsson A, Jägervall Å, Pettersson M, Andersson A-K, Gillberg P-G, Melgar S. (2008) '“Dextran sodium sulphate induces acute colitis and alters hepatic function in hamsters”'. International immunopharmacology, 8 :20-27 [Details] | |
| (2008) | '“High throughput magnetic resonance imaging in murine colonic inflammation”' Melgar S, Gillberg P-G, Hockings PD, and Olsson LE. (2008) '“High throughput magnetic resonance imaging in murine colonic inflammation”'. Biochemical Biophysical Research Communications, 355 :1102-1107 [Details] | |
| (2000) | 'Neuroendocrine changes in colon of mice with a disrupted IL-2 gene' Qian BF, El-Salhy M, Melgar S, Hammarstrom ML, Danielsson A (2000) 'Neuroendocrine changes in colon of mice with a disrupted IL-2 gene'. Clinical and Experimental Immunology, 120 (3):424-433 [Details] | |
| (2006) | '“Local production of chemokines and prostaglandin E2 in the acute, chronic and recovery phase of murine experimental colitis' Melgar S, Drmotova M, Rehnström E, Jansson L, Michaёlsson E. (2006) '“Local production of chemokines and prostaglandin E2 in the acute, chronic and recovery phase of murine experimental colitis'. Cytokine, [Details] | |
| (2014) | 'Effects of anti-inflammatory therapy on bursting pressure of colonic anastomosis in murine dextran sulfate sodium induced colitis' Myrelid P, Salim S, Darby T, Melgar S, Andersson P, Söderholm JD (2014) 'Effects of anti-inflammatory therapy on bursting pressure of colonic anastomosis in murine dextran sulfate sodium induced colitis'. Scandinavian Journal of Gastroenterology, [Details] | |
| (2013) | 'Pellino3 ubiquitinates RIP2 and mediates Nod2-induced signaling and protective effects in colitis' Yang, S,Wang, BW,Humphries, F,Jackson, R,Healy, ME,Bergin, R,Aviello, G,Hall, B,McNamara, D,Darby, T,Quinlan, A,Shanahan, F,Melgar, S,Fallon, PG,Moynagh, PN (2013) 'Pellino3 ubiquitinates RIP2 and mediates Nod2-induced signaling and protective effects in colitis'. Nature immunology, 14 [DOI] [Details] |
Review Articles
| Year | Publication | |
|---|---|---|
| (2012) | Pattern recognition receptors-Molecular orchestrators of inflammation in inflammatory bowel disease. Walsh D, McCarthy J, O'Driscoll C, Melgar S. (2012) Pattern recognition receptors-Molecular orchestrators of inflammation in inflammatory bowel disease. http://www.sciencedirect.com/science/article/pii/S1359610112000779: Review Articles [Details] | |
| (2012) | Shining a Light on Intestinal Traffic. Murphy, CT,Nally, K,Shanahan, F,Melgar, S (2012) Shining a Light on Intestinal Traffic. Review Articles [DOI] [Details] | |
| (2011) | Intestinal delivery of non-viral gene therapeutics: physiological barriers and preclinical models. O'Neill, MJ,Bourre, L,Melgar, S,O'Driscoll, CM (2011) Intestinal delivery of non-viral gene therapeutics: physiological barriers and preclinical models. Review Articles [DOI] [Details] | |
| (2010) | Inflammatory bowel disease-From mechanisms to treatment strategies. Melgar, S,Shanahan, F (2010) Inflammatory bowel disease-From mechanisms to treatment strategies. Review Articles [DOI] [Details] | |
| (2014) | The complex role of inflammasomes in the pathogenesis of Inflammatory Bowel Diseases - Lessons learned from experimental models”. Aguilera M, Darby T, Melgar S (2014) The complex role of inflammasomes in the pathogenesis of Inflammatory Bowel Diseases - Lessons learned from experimental models”. Review Articles [Details] |
Professional Activities
Honours and Awards
| Year | Title | Awarding Body | |
|---|---|---|---|
| 2001 | Travel Award | Umea University-Washington University Scientific exchange programme | |
| 2000 | Travel Award | JC Kempes Akademiska fond and JC Kempes Minnes Akademiska Forsknings fond, Umea, Sweden | |
| 1999 | Travel Award | Medical Facultity, Umea University, Sweden | |
| 2001 | Travel Award | Medical Faculty, Umea University, Sweden |
Professional Associations
| Association | Function | From / To | |
|---|---|---|---|
| American Gastroenterology Association | Member | / | |
| Society of Mucosal Immunology | Member | / | |
| European Crohn's and Colitis Organisation | Member | / |
Committees
| Committee | Function | From / To | |
|---|---|---|---|
| PhD Examinor Ms.Caitlin O’Mahony | Internal Examinor | 2009 / | |
| PhD Examiner Juan F. Burgueno Banus | PhD Examiner | 2014 / 2014 |
Employment
| Employer | Position | From / To | |
|---|---|---|---|
| AstraZeneca R&D Molndal, Sweden | Post-doctoral Fellow | 01-FEB-02 / 31-MAY-05 | |
| AstraZeneca R&D Molndal, Sweden | Senior Research Scientist | 01-JUN-06 / 31-DEC-07 | |
| GlaxoSmithKline, Cork | Principal Scientist | 07-JAN-08 / 20-JAN-12 |
Education
| Year | Institution | Qualification | Subject | |
|---|---|---|---|---|
| 1995 | Umea Univerisity, Sweden | BSC | Molecular Biology | |
| 2002 | Umea University, Sweden | PHD I NIMMUNOLOGY | Immunology |
Languages
| Language | Reading | Writing | Speaking | |
|---|---|---|---|---|
| French | Basic | Basic | Basic | |
| English | Fluent | Fluent | Fluent | |
| Swedish | Fluent | Fluent | Fluent | |
| Spanish | Fluent | Fluent | Fluent |
Journal Activities
| Journal | Role | To / From | |
|---|---|---|---|
| Journal Of Dairy Research | Referee | - | |
| Expert Opinion On Investigational Drugs | Referee | - | |
| Physiology And Behaviour | Referee | - | |
| Journal Of Gene Medicine | Referee | - | |
| Life Sciences | Referee | - | |
| Journal Of Biomedicine And Biotechnology | Referee | - | |
| Digestive Diseases And Sciences | Referee | - | |
| Gastroenterology | Referee | - | |
| British Journal Of Pharmacology | Referee | - | |
| Molecular Medicine | Referee | - | |
| Autophagy | Referee | - | |
| Gut | Referee | - | |
| J Immunol | Referee | - | |
| Bmc Gastroenterol | Referee | - | |
| J Crohns Colitis | Referee | - |
Other Activities
| Description | |
|---|---|
Reviewer for grant application from "The Israel Science Foundation (ISF)" | |
Reviewer assigment for grant applications for “The Broad Medical Research Program, IBD Grants, The Eli and Edythe L. Broad Foundation” |
Teaching Activities
Recent Postgraduates
| Graduation Year | Student Name | Institution | Degree Type | Thesis Title | |
|---|---|---|---|---|---|
| 2014 | Jerzy Woznicki | University College Cork | PHD | Molecular mechanisms underpinning IFN-g and TNF-a synergy in intestinal epithelial cells | |
| 2014 | Trevor Darby | University College Cork | PHD | Molecular analysis of inflammatory mechanisms associated with Escherichia coli and Inflammatory Bowel Diseases | |
| 2012 | Carola T Murphy | University College Cork | PHD | Investigation of the mechanisms underpinning leukocyte trafficking in animal models of intestinal inflammation | |
| 2014 | Ruth Bourke | University College Cork | MSc | Molecular analysis of macrophage and adipocyte responses in mice fed high fat diet and its contribution to experimental colitis progression | |
| 2014 | Leanne O’ Riordan | University College Cork | MSc Bioinformatics | Translational analysis of fecal microbiota composition in animal models of colitis to Inflammatory Bowel Disease patients | |
| 2014 | Siobhan McDonnell | University College Cork | MSc | An Analysis of the Immune Responses Provoked by Crohn’s Disease Associated Adherent Invasive Escherichia coli in Intestinal Epithelial Cells |
Current Postgraduate Students
| Student | Degree Type | Primary | |
|---|---|---|---|
| Barrett Kevin Paul | Masters Degree by Research | No |
Research Information
Internal Collaborators
| Name | Institute | Country | |
|---|---|---|---|
| Prof Caitriona O'Driscoll | School of Pharmacy | IRELAND | |
| Dr. Paul Cotter | Teagasc Moorepark | IRELAND | |
| Dr Justin McCarthy | Dept of Biochemistry | IRELAND | |
| Prof. Dmitri Papkovsky | Dept of Biochemistry | IRELAND | |
| Dr Susan Joyce | School of Medicine | IRELAND | |
| Dr Ken Nally | Dept of Biochemistry | IRELAND | |
| Dr David Clarke | Microbiology | IRELAND |
External Collaborators
| Name | Organisation/ Institution | Country | |
|---|---|---|---|
| Dr Christine Loscher | Dublin City Univeristy | IRELAND | |
| Prof Paul Moynagh | National University of Ireland Maynooth | IRELAND | |
| Prof Marie-Louise Hammarstrom | Umea University | SWEDEN | |
| Dr Ken Cadwell | NYU | U.S.A. | |
| Prof Johan D Soderholm | Linkoping University | SWEDEN | |
| Dr Ed Lavell | Trinity College Dublin | IRELAND |
Contact details
- Silvia Melgar
Senior Research Co-Ordinator - S.Melgar@ucc.ie
- Alimentary Pharmabotic Centre (Apc)
University College Cork
Cork
Ireland - +353-21-490-3000