BIOGRAPHY
Research Interests
In eukaryotic cells, endosomal trafficking is an essential cellular process which controls the uptake, transport, recycling and degradation of various cellular material. Among the material that is trafficked through endosomes are proteins such as growth factor receptors as well as a further class of cell surface receptors, termed integrins, which mediate cell attachment to its surrounding tissues. When aberrant endosomal trafficking occurs, this sometimes results in altered trafficking of key endosomal-cargo which can contribute to carcinogenesis by altering processes such as the down regulation of growth factor signalling or enhancing integrin-mediated invasive migration of cancer cells which is required for cancer metastasis.
My principal research interests lie in the area of Rab GTPase-mediated control of endosomal trafficking during physiological cellular processes as well as during invasive migration of cancer cells. I am particularly interested in a protein termed Rab25, which regulates endosomal trafficking events in epithelial cells and has also been shown to drive receptor-recycling during invasive cancer cell migration.
Publications
Book Chapters
| Year | Publication | |
|---|---|---|
| (2005) | 'Purification and functional properties of Rab11-FIP3' Horgan CP, Zurawski TH, McCaffrey MW; (2005) 'Purification and functional properties of Rab11-FIP3' In: Methods in enzymology. [DOI] [Details] |
Peer Reviewed Journals
| Year | Publication | |
|---|---|---|
| (2012) | 'Endosomal trafficking in animal cytokinesis' Horgan CP, McCaffrey MW (2012) 'Endosomal trafficking in animal cytokinesis' [Details] | |
| (2011) | 'Rab GTPases and microtubule motors' Horgan CP, McCaffrey MW; (2011) 'Rab GTPases and microtubule motors' [DOI] [Details] | |
| (2011) | 'Dynein LIC1 localizes to the mitotic spindle and midbody and LIC2 localizes to spindle poles during cell division' Horgan, CP,Hanscom, SR,McCaffrey, MW; (2011) 'Dynein LIC1 localizes to the mitotic spindle and midbody and LIC2 localizes to spindle poles during cell division' [DOI] [Details] | |
| (2011) | 'The role of endosomal-recycling in long-term potentiation' Kelly EE, Horgan CP, McCaffrey MW, Young P; (2011) 'The role of endosomal-recycling in long-term potentiation' [DOI] [Details] | |
| (2010) | 'Rab11-FIP3 binds dynein light intermediate chain 2 and its overexpression fragments the Golgi complex' Horgan, CP; Hanscom, SR; Jolly, RS; Futter, CE; McCaffrey, MW; (2010) 'Rab11-FIP3 binds dynein light intermediate chain 2 and its overexpression fragments the Golgi complex' [DOI] [Details] | |
| (2010) | 'Rab11-FIP3 links the Rab11 GTPase and cytoplasmic dynein to mediate transport to the endosomal-recycling compartment' Horgan, CP; Hanscom, SR; Jolly, RS; Futter, CE; McCaffrey, MW; (2010) 'Rab11-FIP3 links the Rab11 GTPase and cytoplasmic dynein to mediate transport to the endosomal-recycling compartment' [DOI] [Details] | |
| (2009) | 'The dynamic Rab11-FIPs' Horgan, CP; McCaffrey, MW; (2009) 'The dynamic Rab11-FIPs' [DOI] [Details] | |
| (2010) | 'Class I Rab11-Family Interacting Proteins are binding targets for the Rab14 GTPase' Kelly EE, Horgan CP, Adams C, Patzer TM, Ní Shúilleabháin DM, Norman JC, McCaffrey MW; (2010) 'Class I Rab11-Family Interacting Proteins are binding targets for the Rab14 GTPase' [DOI] [Details] | |
| (2007) | 'Rab11-FIP3 is critical for the structural integrity of the endosomal recycling compartment' Horgan CP, Oleksy A, Zhdanov AV, Lall PY, White IJ, Khan AR, Futter CE, McCaffrey JG, McCaffrey MW; (2007) 'Rab11-FIP3 is critical for the structural integrity of the endosomal recycling compartment' [DOI] [Details] |
Conference Contributions
| Year | Publication | |
|---|---|---|
| (2011) | Biochemical Society / Wellcome Trust Focused Meeting – Cellular cytoskeletal motor proteins, Horgan CP* and McCaffrey MW (2011) FIP3 mediates transport of material to the endosomal-recycling compartment by linking the Rab11 GTPase to cytoplasmic dynein. [Oral Presentation], Biochemical Society / Wellcome Trust Focused Meeting – Cellular cytoskeletal motor proteins, Cambridge, England , 30-MAR-11 - 01-APR-11 | |
| (2010) | 4th Annual UCC Biochemistry Department 'Talking Science' Research Day, Horgan CP*, Hanscom SR and McCaffrey MW (2010) FIP3 Mediates Transport of Material to the Endosomal-Recycling Compartment by Linking the Rab11 GTPase to Cytoplasmic Dynein. [Poster Presentation], 4th Annual UCC Biochemistry Department 'Talking Science' Research Day, Cork, Ireland , 25-FEB-10 - 25-FEB-10 | |
| (2009) | National Roche Researcher of the Year Competition and Ceremony 2009, Horgan CP* (2009) Investigation of the Functional Interplay between Cytoplasmic Dynein and the Rab11 Effector Protein FIP3. [Invited Oral Presentation], National Roche Researcher of the Year Competition and Ceremony 2009, Dublin, Ireland , 26-NOV-09 - 26-NOV-09 | |
| (2009) | Joint Biochemical Society/British Society for Cell Biology Meeting - ‘The Dynamic Cell’, Horgan CP*, Hanscom SR and McCaffrey MW (2009) FIP3 Mediates Transport of Material to the Endosomal-Recycling Compartment by Linking the Rab11 GTPase to Cytoplasmic Dynein. [Poster Presentation], Joint Biochemical Society/British Society for Cell Biology Meeting - ‘The Dynamic Cell’, Edinburgh, Scotland , 01-APR-09 - 04-APR-09 | |
| (2009) | BioSciences Institute Postdoctoral Researcher of the Year Competition and Award, Horgan CP* (2009) Investigation of the Functional Interplay between Cytoplasmic Dynein and the Rab11 Effector Protein FIP3. [Invited Oral Presentation], BioSciences Institute Postdoctoral Researcher of the Year Competition and Award, Cork, Ireland , 09-NOV-09 - 09-NOV-09 | |
| (2009) | 3rd UCC Biochemistry Department 'Talking Science' Research Day, Horgan CP*, Hanscom SR and McCaffrey MW (2009) FIP3 Mediates Transport of Material to the Endosomal-Recycling Compartment by Linking the Rab11 GTPase to Cytoplasmic Dynein. [Poster Presentation], 3rd UCC Biochemistry Department 'Talking Science' Research Day, Cork, Ireland , 09-APR-09 - 09-APR-09 | |
| (2008) | 2nd UCC Biochemistry Department 'Talking Science' Research Day, Horgan CP*, Oleksy A, Zhdanov AV, Lall PY, White IJ, Khan AR, Futter CE, McCaffrey JG and McCaffrey MW (2008) Rab11-FIP3 is an Indispensable Component of the Endosomal-Recycling Compartment Machinery. [Poster Presentation], 2nd UCC Biochemistry Department 'Talking Science' Research Day, Cork, Ireland , 15-AUG-08 - 15-AUG-08 | |
| (2008) | Science Foundation Ireland (SFI) Science Summit 2008, Horgan CP, Hanscom SR and McCaffrey MW* (2008) FIP3 Mediates Transport of Material to the Endosomal-Recycling Compartment by Linking the Rab11 GTPase to Cytoplasmic Dynein. [Poster Presentation], Science Foundation Ireland (SFI) Science Summit 2008, Kilkenny, Ireland , 17-NOV-08 - 18-NOV-08 | |
| (2008) | Inaugural UCC Biochemistry Department 'Talking Science' Research Day, Oleksy A*, Horgan CP, Zhdanov AV, Lall PY, White IJ, Khan AR, Futter CE, McCaffrey JG and McCaffrey MW (2008) Rab11-FIP3 serves a critical role in maintaining the structural integrity of the endosomal-recycling compartment (ERC). [Poster Presentation], Inaugural UCC Biochemistry Department 'Talking Science' Research Day, Cork, Ireland , 08-FEB-08 - 08-FEB-08 | |
| (2008) | Beatson Institute Workshop – Vesicular Transport and Cancer, Horgan CP*, Hanscom SR and McCaffrey MW (2008) FIP3 Mediates Transport of Material to the Endosomal-Recycling Compartment by Linking the Rab11 GTPase to Cytoplasmic Dynein. [Poster Presentation], Beatson Institute Workshop – Vesicular Transport and Cancer, Glasgow, Scotland , 21-SEP-08 - 23-SEP-08 | |
| (2008) | Inaugural UCC Biochemistry Department 'Talking Science' Research Day, Horgan CP* and McCaffrey MW (2008) Rab11-FIP3 – A Lot Done, More to Do. [Invited Oral Presentation], Inaugural UCC Biochemistry Department 'Talking Science' Research Day, Cork, Ireland , 08-FEB-08 - 08-FEB-08 | |
| (2007) | Irish Association for Cancer Research (IACR) Annual Meeting, Horgan CP* and McCaffrey MW (2007) Rab11-FIP3 couples Rab11 and ARF6 to deliver endosomally-derived material to the cleavage furrow/midbody during cytokinesis. [Poster Presentation], Irish Association for Cancer Research (IACR) Annual Meeting, Cork, Ireland , 02-MAR-07 - 03-MAR-07 | |
| (2007) | Joint American Society for Cell Biology (ASCB)/European Cytoskeleton Forum (ECF) Summer Meeting. “Dynamic Interplay between Cytoskeletal and Membrane Systems, Horgan CP*, Oleksy A, Zhdanov AV, Lall PY, White IJ, Khan AR, Futter CE, McCaffrey JG and McCaffrey MW (2007) A Rab11-Mediated Role for Rab11-FIP3 in Maintaining the Structural Integrity of the Endosomal-Recycling Compartment. [Poster Presentation], Joint American Society for Cell Biology (ASCB)/European Cytoskeleton Forum (ECF) Summer Meeting. “Dynamic Interplay between Cytoskeletal and Membrane Systems, Dijon, France , 27-JUN-07 - 30-JUN-07 | |
| (2007) | Science Foundation Ireland (SFI) Science Summit 2007, Horgan CP*, Oleksy A, Zhdanov AV, Lall PY, White IJ, Khan AR, Futter CE, McCaffrey JG and McCaffrey MW (2007) A Rab11-Mediated Role for Rab11-FIP3 in Maintaining the Structural Integrity of the Endosomal-Recycling Compartment. [Poster Presentation], Science Foundation Ireland (SFI) Science Summit 2007, Dublin, Ireland , 26-NOV-07 - 27-NOV-07 | |
| (2007) | EMBO workshop: 'Endocytic systems: mechanism and function', Oleksy A*, Horgan CP, Zhdanov AV, Lall PY, White IJ, Khan AR, Futter CE, McCaffrey JG and McCaffrey MW (2007) Rab11-FIP3 serves a critical role in maintaining the structural integrity of the endosomal-recycling compartment (ERC). [Poster Presentation], EMBO workshop: 'Endocytic systems: mechanism and function', Geneva, Switzerland , 18-SEP-07 - 23-SEP-07 | |
| (2006) | Royal Microscopical Society – British Society for Cell Biology (RMS-BSCB), Imaging Membrane Dynamics Meeting, Horgan CP*, Zhdanov AV, Oleksy A, Lall PY, McCaffrey JG and McCaffrey MW (2006) Rab11-FIP3 is critical for the structural integrity of the endosomal-recycling compartment. [Oral Presentation], Royal Microscopical Society – British Society for Cell Biology (RMS-BSCB), Imaging Membrane Dynamics Meeting, Egham, England , 14-SEP-06 - 17-SEP-06 | |
| (2006) | The American Society for Cell Biology (ASCB) Annual Meeting, Horgan CP, Lindsay AJ*, Zhdanov AV, Oleksy A, Lall PY, McCaffrey JG and McCaffrey MW (2006) Rab11-FIP3 is required to maintain the endosomal-recycling compartment. [Poster Presentation], The American Society for Cell Biology (ASCB) Annual Meeting, San Diego, California, USA , 09-DEC-06 - 13-DEC-06 | |
| (2005) | Irish Area Section (IAS) Biochemical Society Pre-doctoral Meeting, Horgan CP* and McCaffrey MW (2005) Characterisation of the Rab11-FIP3 protein in endosomal-recycling and cytokinesis. [Invited Oral Presentation], Irish Area Section (IAS) Biochemical Society Pre-doctoral Meeting, Maynooth, Ireland , 07-OCT-05 - 07-OCT-05 | |
| (2005) | Irish Research Council for Science, Engineering and Technology (IRCSET) National Research Symposium, Horgan CP* and McCaffrey MW (2005) Characterisation of the Rab11-Family Interacting Protein 3 (Rab11-FIP3) in Eukaryotic membrane trafficking. [Poster Presentation], Irish Research Council for Science, Engineering and Technology (IRCSET) National Research Symposium, Dublin, Ireland , 03-NOV-05 - 03-NOV-05 | |
| (2004) | Joint EMBO/FEBS Workshop, organised by the EURESCO Office - European Science Foundation (ESF) 'Frontiers of Cellular Microbiology and Cell Biology; Spatial and Temporal Dynamics of the Endomembrane System', Horgan CP*, Walsh M, Zurawski TH and McCaffrey MW (2004) Rab11-FIP3, an endosomal-recycling compartment associated protein, relocates to the cleavage furrow during cytokinesis. [Poster Presentation], Joint EMBO/FEBS Workshop, organised by the EURESCO Office - European Science Foundation (ESF) 'Frontiers of Cellular Microbiology and Cell Biology; Spatial and Temporal Dynamics of the Endomembrane System', San Feliu de Guixols, Spain , 16-OCT-04 - 21-OCT-04 | |
| (2004) | The American Society for Cell Biology (ASCB) Summer Meeting on Cytokinesis, Horgan CP, Walsh M, Zurawski TH and McCaffrey MW* (2004) Rab11-FIP3 localises to a Rab11-positive pericentrosomal compartment during interphase and to the cleavage furrow during cytokinesis. [Poster Presentation], The American Society for Cell Biology (ASCB) Summer Meeting on Cytokinesis, Burlington, USA , 22-JUL-04 - 25-JUL-04 | |
| (2004) | Irish Research Council for Science, Engineering and Technology (IRCSET) National Research Symposium, Horgan CP*, Walsh M, Zurawski TH and McCaffrey MW (2004) Rab11-FIP3, an endosomal-recycling compartment associated protein, relocates to the cleavage furrow during cytokinesis. [Poster Presentation], Irish Research Council for Science, Engineering and Technology (IRCSET) National Research Symposium, Dublin, Ireland , 02-NOV-04 - 02-NOV-04 | |
| (2004) | Biosciences Institute (BSI) Seminar Series 2004, Horgan CP* and McCaffrey MW (2004) Towards an understanding of Rab11-FIP3 function…. [Invited Oral Presentation], Biosciences Institute (BSI) Seminar Series 2004, Cork, Ireland , 05-OCT-04 - 05-OCT-04 | |
| (2003) | Irish Research Council for Science, Engineering and Technology (IRCSET) National Research Symposium, Horgan CP* and McCaffrey MW (2003) Characterisation of the Rab11-FIP3 protein in eukaryotic membrane trafficking. [Poster Presentation], Irish Research Council for Science, Engineering and Technology (IRCSET) National Research Symposium, Dublin, Ireland , 07-NOV-03 - 07-NOV-03 | |
| (2002) | EMBL PhD Student International Symposium 'Life within Boundaries - Membranes & Compartments in Biology', Horgan CP* (2002) EMBL PhD Student International Symposium. [Other], EMBL PhD Student International Symposium 'Life within Boundaries - Membranes & Compartments in Biology', Heidelberg, Germany , 14-NOV-02 - 16-NOV-02 |
Professional Activities
Honours and Awards
| Year | Title | Awarding Body | |
|---|---|---|---|
| 2011 | Irish Cancer Society Research Fellowship Recipient | Irish Cancer Society (ICS) | |
| 2010 | Best poster presentation prize recipient at the 4th Annual UCC Biochemistry Department Research Day | UCC Biochemistry Department | |
| 2009 | Winner of the BioSciences Institute Postdoctoral Researcher of the Year Award | Roche Diagnostics/University College Cork | |
| 2007 | Poster presentation prize recipient at the Irish Association for Cancer Research Annual Meeting | Irish Association for Cancer Research | |
| 2002 | Irish Research Council for Science, Engineering and Technology (IRCSET) Postgraduate Research Scholarship Recipient | Irish Research Council for Science, Engineering and Technology (IRCSET) |
Associations
| Assocation | Function | From / To | |
|---|---|---|---|
| The Biochemical Society | Member | / |
Employment
| Employer | Position | From / To | |
|---|---|---|---|
| University College Cork | Research Fellow | 01-NOV-11 / | |
| University College Cork | Post-Doctoral Researcher | 01-OCT-06 / 31-OCT-11 |
Other Activities
| Description | |
|---|---|
Workshop Attendance: Inaugural Irish Cancer Society Grant Writing Workshop. Dublin, Ireland. 11 January, 2011 | |
Workshop Attendance: Health Research Board (HRB) and British Council Science Writing Workshop. Cork, Ireland. 23-24 May, 2005 |
Contact details
- Conor Horgan
Research Fellow - Conor.Horgan@ucc.ie
- Biosciences Instittute
University College Cork
Cork
Ireland - +353-21-490-3000
- Irish Cancer Society Research Fellow
- conor.horgan@ucc.ie
- Biosciences Institute (Bsi)
330
Molecular Cell Biology Laboratory, Biochemistry Department, Biosciences Institute
University College Cork
Cork
Ireland - +353-21-490-1367