His current research is in the area of organic synthesis applied to biologically significant molecules. En route to these compounds, novel methodology involving organometallic and asymmetric synthesis is being employed. Dr McGlacken has authored about 80 peer-reviewed publications, in high impact journals such as Nature Catalysis, Angew. Chem. Int. Ed., Org. Lett, Chem. Commun., ACS Catalysis and Chem. Eur. J., and has received over 2900 citations. He is also a named author on a number of patents (UK and US). He has received over €3 million in competitive funding as part of the Science Foundation Ireland Research Frontiers Program (2009), the Investigators Program (2011) and others. He has also received two Technology and Innovation Development Awards from SFI. He works closely with the Pharmaceutical Industry both in Ireland and the United States and has received applied grants with Eli Lilly (2010) and Merck (2015) as part of the Enterprise Ireland Innovation Partnership program. We was award a 100%-Eli Lilly funded (LRAP) Award in 2018. He also collaborates with the large Pharma company Syngenta and has placed PhD students in Basel, Switzerland. He has collaborated with Pfizer as part of the Irish Research Council Industry Partnership Program which resulted in the funding of three PhD positions, most recently in 2021. He has been invited to give several guest lectures internationally, recently (2018) at the International Symposium on CH Activation at Keio University, Japan. Dr McGlacken was Vice-Chairman of the European COST Action CA15106 - CH Activation in Organic Synthesis (CHAOS). He was also the External Examiner for the Dundalk Institute of Technology Pharmaceutical Sciences Program from 2010-2014. Dr McGlacken's Group has been involved in a number of popular science and dissemination programs including the receipt of First Prize by PhD student Sarah Clarke in the UCC Doctoral Showcase. Dr McGlacken is a Funded Investigator within the Synthesis and Solid State Pharmaceutical Centre (SSPC) research centre. It is a Global Hub of Pharmaceutical Process Innovation and Advanced Manufacturing, and a unique collaboration between 17 industry partners, 8 academic institutions and 12 international academic collaborators. Dr McGlacken has a keen interest in the 'Research of Teaching' and treating Teaching as a discipline in itself. This has motivated him to complete a Certificate and Diploma in 'Teaching and Learning in High Education' and he has published in the Journal of Chemical Education.
In 2016, he was part of a Team which won the UCC Innovation of the Year Award.
In 2020, he was the recipient of the President's Prize for Excellence in Teaching.
In 2021, he was appointed Vice-Dean of Research and Innovation at the College of Science, Engineering and Food Science. Finally in 2021 he was also elected to the UCC Academic Council.
Biography
Dr Gerard McGlacken obtained his B.Sc. at the National University of Ireland, Galway. He remained in Galway for his Ph.D. studies where he focused on hydrazones as building blocks for asymmetric synthesis. He then moved to the University of York (UK) where his research interests diversified to organometallic transformations and molecules of biological importance with Prof. Ian J. S. Fairlamb. A year later, he took up a 'Molecular Design and Synthesis Post-Doctoral Fellowship' at Florida State University (US) working with Prof. Robert A. Holton on the total synthesis of the large polyether antibiotic lonomycin A. He obtained a Lectureship position at University College Cork in 2007 and a permanent position in 2011. He was promoted to Senior Lecturer in 2018.His current research is in the area of organic synthesis applied to biologically significant molecules. En route to these compounds, novel methodology involving organometallic and asymmetric synthesis is being employed. Dr McGlacken has authored about 80 peer-reviewed publications, in high impact journals such as Nature Catalysis, Angew. Chem. Int. Ed., Org. Lett, Chem. Commun., ACS Catalysis and Chem. Eur. J., and has received over 2900 citations. He is also a named author on a number of patents (UK and US). He has received over €3 million in competitive funding as part of the Science Foundation Ireland Research Frontiers Program (2009), the Investigators Program (2011) and others. He has also received two Technology and Innovation Development Awards from SFI. He works closely with the Pharmaceutical Industry both in Ireland and the United States and has received applied grants with Eli Lilly (2010) and Merck (2015) as part of the Enterprise Ireland Innovation Partnership program. We was award a 100%-Eli Lilly funded (LRAP) Award in 2018. He also collaborates with the large Pharma company Syngenta and has placed PhD students in Basel, Switzerland. He has collaborated with Pfizer as part of the Irish Research Council Industry Partnership Program which resulted in the funding of three PhD positions, most recently in 2021. He has been invited to give several guest lectures internationally, recently (2018) at the International Symposium on CH Activation at Keio University, Japan. Dr McGlacken was Vice-Chairman of the European COST Action CA15106 - CH Activation in Organic Synthesis (CHAOS). He was also the External Examiner for the Dundalk Institute of Technology Pharmaceutical Sciences Program from 2010-2014. Dr McGlacken's Group has been involved in a number of popular science and dissemination programs including the receipt of First Prize by PhD student Sarah Clarke in the UCC Doctoral Showcase. Dr McGlacken is a Funded Investigator within the Synthesis and Solid State Pharmaceutical Centre (SSPC) research centre. It is a Global Hub of Pharmaceutical Process Innovation and Advanced Manufacturing, and a unique collaboration between 17 industry partners, 8 academic institutions and 12 international academic collaborators. Dr McGlacken has a keen interest in the 'Research of Teaching' and treating Teaching as a discipline in itself. This has motivated him to complete a Certificate and Diploma in 'Teaching and Learning in High Education' and he has published in the Journal of Chemical Education.
In 2016, he was part of a Team which won the UCC Innovation of the Year Award.
In 2020, he was the recipient of the President's Prize for Excellence in Teaching.
In 2021, he was appointed Vice-Dean of Research and Innovation at the College of Science, Engineering and Food Science. Finally in 2021 he was also elected to the UCC Academic Council.
Research Interests
Organic Synthesis
The Irish Chemical Industry exported 44.17 billion euro worth of Pharmaceuticals in 2009. It remains one of the strongest performing industries and has been largely recession-proof. Ireland is moving away from Process Chemistry, up the value chain towards Research and Discovery. Key skills acquired during a PhD term within my group will equip researchers with the essentials to progress into this Sector.
Area 1 Asymmetric Synthesis
Importantly, 60% of all drugs now containing at least one chiral centre (this is usually a carbon atom bound to four different groups). Thus asymmetric synthesis is of upmost importance.
A: The synthesis of chiral α-substituted ketones
The introduction of such a chiral centre is challenging but potentially very useful to the Pharmaceutical Sector. (-)-Sparteine, isolated from thermopsis lanceolatais plant is chiral. We use this inbuilt chirality from nature and transfer it to ketones.
B: The synthesis of chiral amino acids.
The 1,3-hydroxyketone in a very common and important moiety in pharmaceutical compounds. This project involves the asymmetric synthesis of these compounds containing two, three or even more centres all in the one-pot experiment.
Area 2 Organometallic transformations
The abundance of the biaryl structural motif in natural products, biologically active molecules and in materials chemistry has positioned aryl-aryl (Ar-Ar) bond formation high on the agenda of synthetic chemists. For decades well-known reactions such as the Mizoroki-Heck and Suzuki-Miyaura have been the methods of choice to furnish biaryls. More recently however, alternative methods, most notably direct arylation via C-H activation, have become the focus of many research groups including ours. Compared to traditional methods, direct arylation affords ArAr compounds in fewer steps by removing the need for pre-functionalisation. Furthermore, given that either one or two hydrogens are targeted, less waste and good atom economy are features of this methodology. We use C-H activation in biologically important synthons.
Area 3 Synthesis of non-traditional antibiotics and biomarker detection
Bacteria produce small-molecule signals to help coordinate their behaviour. This communication system serves many purposes, including cooperative tasks such as the formation of protective biofilms. These protective sheets greatly impair the effectiveness of antibiotics. This, added to the growing resistance to antibiotics, necessitates an alternative look at treating bacteria infections. We prepare analogues of bacteria communication molecules to interrupt their communication systems and prevent biofilm formation. In this non-biocidal approach, developed resistance is avoided. In parallel, early detection of these molecules allows for early medical intervention.
Research Grants
| Project | Funding Body | Start Date | End Date | Award | |
|---|---|---|---|---|---|
| Suppored Nanocatalysts for the Pharmaceutical Industry. | Industry/EI Projects | 01-JAN-12 | 31-JUL-13 | €30,860.00 | |
| Direct Arylation and Fluorination using Supported Palladium Catalysts. | Enterprise Irl | 01-NOV-14 | 01-SEP-16 | €169,851.00 | |
| Heterogeneeous Catalysis for the Direct Arylation of Heterocycles. | Irish Research Council | 01-OCT-14 | 30-SEP-16 | €91,790.00 | |
| The asymmetric synthesis of 1,3 aminoalchols. | Irish Research Council for Science, Engineering & Technology (IRCSET) | 01-SEP-10 | 30-SEP-13 | €72,009.00 | |
| The asymmetric synthesis of a-substituted ketones and application to Total Synthesis. | Irish Research Council for Science, Engineering & Technology (IRCSET) | 01-SEP-10 | 31-AUG-14 | €72,009.00 | |
| Optimised detection of key biomarkers of Pseudomonas aeruginosa towards a clinical application | Science Foundation of Ireland | 01-JAN-13 | 31-MAR-14 | €128,295.00 | |
| SFI The asymmetric synthesis of 1.3-hydroxyketones using hydrazones with (-) sparteine as a chiral ligand and 1.3-aminoalcohols using an aldol-Tishchenko type reaction with sulfinylimines. | Science Foundation of Ireland | 01-SEP-09 | 31-AUG-13 | €198,831.00 | |
| New metholdology towards chiral ketones and animoalcohols. | Irish Research Council | 01-OCT-14 | 30-SEP-18 | €96,000.00 | |
| The catalytic asymmetric Alkylation of Ketones | Irish Research Council for Science, Engineering & Technology (IRCSET) | 29-AUG-11 | 28-AUG-15 | €72,000.00 | |
| The Direct Arylation of Pyrones, Courmarins. | Science Foundation of Ireland | 01-APR-13 | 31-DEC-17 | €377,092.00 | |
| Supported Nanocatgalysts for the Pharmaceutical Industry. | Enterprise Irl | 01-JAN-12 | 07-OCT-13 | €98,807.00 | |
| Direct Arylation and Fluorination using Supported Palladium Catalysts. | Industry/EI Projects | 01-NOV-14 | 01-SEP-16 | €40,854.00 | |
| The synthesis of biologically important heterocycles. | Irish Research Council | 01-OCT-13 | 30-SEP-17 | €96,000.00 |
Publications
Peer Reviewed Journals
| Year | Publication | |
|---|---|---|
| (2021) | 'Stereoselective Installation of Five Contiguous Stereogenic Centers in a Double Aldol-Tishchenko Cascade and Evaluation of the Key Transition State through DFT Calculation' Mackey P;Turlik A;Ando K;Light ME;Houk KN;McGlacken GP; (2021) 'Stereoselective Installation of Five Contiguous Stereogenic Centers in a Double Aldol-Tishchenko Cascade and Evaluation of the Key Transition State through DFT Calculation'. Organic letters, 23 (16) [DOI] [Details] | |
| (2021) | 'Mechanism and Origins of Stereoselectivity of the Aldol-Tishchenko Reaction of Sulfinimines' Turlik A;Ando K;Mackey P;Alcock E;Light M;McGlacken GP;Houk KN; (2021) 'Mechanism and Origins of Stereoselectivity of the Aldol-Tishchenko Reaction of Sulfinimines'. Journal of Organic Chemistry, 86 (5) [DOI] [Details] | |
| (2021) | 'Quinoline Ligands Improve the Classic Direct C-H Functionalisation/Intramolecular Cyclisation of Diaryl Ethers to Dibenzofurans' Mackey, K;Jones, DJ;Pardo, LM;McGlacken, GP (2021) 'Quinoline Ligands Improve the Classic Direct C-H Functionalisation/Intramolecular Cyclisation of Diaryl Ethers to Dibenzofurans'. European Journal of Organic Chemistry, [DOI] [Details] | |
| (2020) | 'Detection of Pseudomonas aeruginosa quorum sensing molecules at an electrified liquid|liquid micro-interface through facilitated proton transfer' Burgoyne, ED;Molina-Osorio, AF;Moshrefi, R;Shanahan, R;McGlacken, GP;Stockmann, TJ;Scanlon, MD (2020) 'Detection of Pseudomonas aeruginosa quorum sensing molecules at an electrified liquid|liquid micro-interface through facilitated proton transfer'. Analyst, 145 :7000-7008 [DOI] [Details] | |
| (2020) | 'Organolithium Bases in Flow Chemistry: A Review' Power, Mark; Alcock, Emma; McGlacken, Gerard P. (2020) 'Organolithium Bases in Flow Chemistry: A Review'. Organic Process Research & Development, [DOI] [Full Text] [Details] | |
| (2020) | 'One-Pot, Tandem Wittig Hydrogenation: Formal C(sp3)-C(sp3) Bond Formation with Extensive Scope' Devlin R.;Jones D.J.;McGlacken G.P. (2020) 'One-Pot, Tandem Wittig Hydrogenation: Formal C(sp3)-C(sp3) Bond Formation with Extensive Scope'. Organic letters, 22 (13):5223-5228 [DOI] [Details] | |
| (2020) | 'One-Pot, Tandem Wittig Hydrogenation: Formal C(sp3)-C(sp3) Bond Formation with Extensive Scope' Devlin R.;Jones D.J.;McGlacken G.P. (2020) 'One-Pot, Tandem Wittig Hydrogenation: Formal C(sp3)-C(sp3) Bond Formation with Extensive Scope'. Organic letters, [DOI] [Details] | |
| (2020) | 'One-Pot Cross-Coupling/C-H Functionalization Reactions: Quinoline as a Substrate and Ligand through N-Pd Interaction' Shanahan RM;Hickey A;Bateman LM;Light ME;McGlacken GP; (2020) 'One-Pot Cross-Coupling/C-H Functionalization Reactions: Quinoline as a Substrate and Ligand through N-Pd Interaction'. Journal of Organic Chemistry, [DOI] [Details] | |
| (2020) | 'A structure-function analysis of interspecies antagonism by the 2-heptyl-4-alkyl-quinolone signal molecule from Pseudomonas aeruginosa' Ramos A.F.;Woods D.F.;Shanahan R.;Cano R.;McGlacken G.P.;Serra C.;O'Gara F.;Reen F.J. (2020) 'A structure-function analysis of interspecies antagonism by the 2-heptyl-4-alkyl-quinolone signal molecule from Pseudomonas aeruginosa'. Microbiology-SGM, 166 (2):169-179 [DOI] [Details] | |
| (2019) | 'The emergence of Pd-mediated reversible oxidative addition in cross coupling, carbohalogenation and carbonylation reactions' Jones, David J.; Lautens, Mark; McGlacken, Gerard P. (2019) 'The emergence of Pd-mediated reversible oxidative addition in cross coupling, carbohalogenation and carbonylation reactions'. Nature Catalysis, 2 (10):843-851 [DOI] [Full Text] [Details] | |
| (2019) | 'Electrochemical detection of Pseudomonas aeruginosa quorum sensing molecules at a liquid|liquid interface' Burgoyne, Edward D.; Stockmann, Talia Jane; Molina-Osorio, Andrés F.; Shanahan, Rachel; McGlacken, Gerard P.; Scanlon, Micheál D. (2019) 'Electrochemical detection of Pseudomonas aeruginosa quorum sensing molecules at a liquid|liquid interface'. The Journal Of Physical Chemistry C, [DOI] [Full Text] [Details] | |
| (2019) | 'Synthesis of a Diaryliodonium Salt and Its Use in the Direct Arylation of Indole: A Two-Step Experiment for the Organic Teaching Laboratory' Prendergast A.;Shanahan R.;Hickey A.;Harrington F.;Schönbauer D.;Byrne P.;Schnürch M.;McGlacken G. (2019) 'Synthesis of a Diaryliodonium Salt and Its Use in the Direct Arylation of Indole: A Two-Step Experiment for the Organic Teaching Laboratory'. Journal Of Chemical Education, [DOI] [Details] | |
| (2018) | 'Recent advances in manganese-catalysed C–H activation: scope and mechanism' Cano, Rafael; Mackey, Katrina; McGlacken, Gerard P. (2018) 'Recent advances in manganese-catalysed C–H activation: scope and mechanism'. Catalysis Science & Technology, 8 (5):1251-1266 [DOI] [Full Text] [Details] | |
| (2018) | 'Quinolones Modulate Ghrelin Receptor Signaling: Potential for a Novel Small Molecule Scaffold in the Treatment of Cachexia' Torres-Fuentes, C;Pastor-Cavada, E;Cano, R;Kandil, D;Shanahan, R;Juan, R;Shaban, H;McGlacken, GP;Schellekens, H (2018) 'Quinolones Modulate Ghrelin Receptor Signaling: Potential for a Novel Small Molecule Scaffold in the Treatment of Cachexia'. International Journal of Molecular Sciences, 19 [DOI] [Details] | |
| (2018) | 'Synthesis of Benzofuroquinolines via Phosphine-Free Direct Arylation of 4-Phenoxyquinolines in Air' Shanahan, R.M., Hickey, A., Reen, F.J., O'Gara, F. and McGlacken, G.P. (2018) 'Synthesis of Benzofuroquinolines via Phosphine-Free Direct Arylation of 4-Phenoxyquinolines in Air'. European Journal of Organic Chemistry, [DOI] [Details] | |
| (2018) | 'Analogues of Pseudomonas aeruginosa signalling molecules to tackle infections' Ó Muimhneacháin E, Reen F.J., O'Gara F, McGlacken G.P. (2018) 'Analogues of Pseudomonas aeruginosa signalling molecules to tackle infections'. Organic and Biomolecular Chemistry, 16 (2):169-179 [DOI] [Details] | |
| (2018) | 'Rapid electrochemical detection of pseudomonas aeruginosa signaling molecules by boron-doped diamond electrode' Buzid A.;Luong J.;Reen F.;O’Gara F.;Glennon J.;McGlacken G. (2018) 'Rapid electrochemical detection of pseudomonas aeruginosa signaling molecules by boron-doped diamond electrode'. Live Cell Imaging: Methods And Protocols, 1673 :107-116 [DOI] [Details] | |
| (2018) | 'Electrochemical Sensing of Biotin Using Nafion-Modified Boron-Doped Diamond Electrode' Buzid, A;McGlacken, GP;Glennon, JD;Luong, JHT (2018) 'Electrochemical Sensing of Biotin Using Nafion-Modified Boron-Doped Diamond Electrode'. ACS Omega, 3 :7776-7782 [DOI] [Details] | |
| (2018) | 'Industry–Academia Partnership: The Synthesis and Solid-State Pharmaceutical Centre (SSPC) as a Collaborative Approach from Molecule to Medicine' McGlacken G.;Hayes S.;Maguire A.;O'Halloran J.;Hodnett K. (2018) 'Industry–Academia Partnership: The Synthesis and Solid-State Pharmaceutical Centre (SSPC) as a Collaborative Approach from Molecule to Medicine'. Chemistry - A European Journal, 24 (2):499-503 [DOI] [Details] | |
| (2018) | 'Simultaneous chemosensing of tryptophan and the bacterial signal molecule indole by boron doped diamond electrode' Buzid, A;Reen, FJ;O'Gara, F;McGlacken, GP;Glennon, JD;Luong, JHT (2018) 'Simultaneous chemosensing of tryptophan and the bacterial signal molecule indole by boron doped diamond electrode'. Electrochimica Acta, 282 :845-852 [DOI] [Details] | |
| (2018) | 'Mechanistic studies on the palladium-catalyzed cross-dehydrogenative coupling of 4-phenoxy-2-coumarins: experimental and computational insights' Prendergast, AM;Zhang, ZH;Lin, ZY;McGlacken, GP (2018) 'Mechanistic studies on the palladium-catalyzed cross-dehydrogenative coupling of 4-phenoxy-2-coumarins: experimental and computational insights'. Dalton Transactions, 47 :6049-6053 [DOI] [Details] | |
| (2017) | 'Intramolecular Direct Arylation of 1,3-Diketone-Derived Enol Ethers in a Synthesis of Tricyclic Oxoisochromene Derivatives' Muimhneachain, EO;Pardo, LM;Bateman, LM;Khandavilli, UBR;Lawrence, SE;McGlacken, GP (2017) 'Intramolecular Direct Arylation of 1,3-Diketone-Derived Enol Ethers in a Synthesis of Tricyclic Oxoisochromene Derivatives'. Advanced Synthesis and Catalysis, 359 :1529-1534 [DOI] [Details] | |
| (2017) | 'Liquid-Phase Monolayer Doping of InGaAs with Si-, S- and Sn-Containing Organic Molecular Layers' O'Connell, J., Napolitani, E., Impellizzeri, G., Glynn, C., McGlacken, G., O'Dwyer, C., Duffy, R. & Holmes, J. D. (2017) 'Liquid-Phase Monolayer Doping of InGaAs with Si-, S- and Sn-Containing Organic Molecular Layers'. ACS Omega, 2 :1750-1759 [DOI] [Full Text] [Details] | |
| (2017) | 'Regioselective Chlorination and Suzuki-Miyaura Cross-Coupling of 4-Alkoxycoumarins, 4-Alkoxy-2-pyrones, and Related Heterocycles' Prendergast, AM;McGlacken, GP (2017) 'Regioselective Chlorination and Suzuki-Miyaura Cross-Coupling of 4-Alkoxycoumarins, 4-Alkoxy-2-pyrones, and Related Heterocycles'. European Journal of Organic Chemistry, :4827-4835 [DOI] [Details] | |
| (2017) | 'The requirements at the C-3 position of alkylquinolones for signalling in Pseudomonas aeruginosa' Shanahan, R.,Reen, F. J.,Cano, R.,O'Gara, F.,McGlacken, G. P. (2017) 'The requirements at the C-3 position of alkylquinolones for signalling in Pseudomonas aeruginosa'. Org Biomol Chem, 15 (2):306-310 [DOI] [Details] | |
| (2017) | 'Direct and Rapid Electrochemical Detection of Pseudomonas aeruginosa Quorum Signaling Molecules in Bacterial Cultures and Cystic Fibrosis Sputum Samples through Cationic Surfactant-Assisted Membrane Disruption' Alyah Buzid, F. Jerry Reen, Victor K. Langsi, Eoin Ó Muimhneacháin, Fergal O'Gara, Gerard P. McGlacken, John H. T. Luong, Jeremy D. Glennon (2017) 'Direct and Rapid Electrochemical Detection of Pseudomonas aeruginosa Quorum Signaling Molecules in Bacterial Cultures and Cystic Fibrosis Sputum Samples through Cationic Surfactant-Assisted Membrane Disruption'. ChemElectroChem, 4 (3) [DOI] [Details] | |
| (2017) | 'Access to some C5-cyclised 2 pyrones and 2-pyridones via direct arylation; retention of chloride as a synthetic handle' McGlacken, Gerard P.; Fairlamb, Ian; Prendergast, Aisling; Pardo, Leticia (2017) 'Access to some C5-cyclised 2 pyrones and 2-pyridones via direct arylation; retention of chloride as a synthetic handle'. European Journal of Organic Chemistry, [DOI] [Full Text] [Details] | |
| (2017) | 'Analogues of Pseudomonas aeruginosa signalling molecules to tackle infections' O. Muimhneachain E,Reen, F. J.,O'Gara, F.,McGlacken, G. P. (2017) 'Analogues of Pseudomonas aeruginosa signalling molecules to tackle infections'. Org Biomol Chem, [DOI] [Details] | |
| (2017) | 'The Bacteroidales produce an N-acylated derivative of glycine with both cholesterol-solubilising and hemolytic activity' Lynch A;Crowley E;Casey E;Cano R;Shanahan R;McGlacken G;Marchesi JR;Clarke DJ; (2017) 'The Bacteroidales produce an N-acylated derivative of glycine with both cholesterol-solubilising and hemolytic activity'. Scientific Reports, 7 (1) [DOI] [Details] | |
| (2016) | 'The search for an easily-prepared sparteine surrogate' Foley, VM;Cano, R;McGlacken, GP (2016) 'The search for an easily-prepared sparteine surrogate'. Tetrahedron: Asymmetry, 27 :1160-1167 [DOI] [Details] | |
| (2016) | 'Harnessing Bacterial Signals for Suppression of Biofilm Formation in the Nosocomial Fungal Pathogen Aspergillus fumigatus' Reen, F. J.,Phelan, J. P.,Woods, D. F.,Shanahan, R.,Cano, R.,Clarke, S.,McGlacken, G. P.,O'Gara, F. (2016) 'Harnessing Bacterial Signals for Suppression of Biofilm Formation in the Nosocomial Fungal Pathogen Aspergillus fumigatus'. Front Microbiol, 7 [DOI] [Details] | |
| (2016) | 'Cyclization of 4-Phenoxy-2-coumarins and 2-Pyrones via a Double C-H Activation' Mackey K;Pardo LM;Prendergast AM;Nolan MT;Bateman LM;McGlacken GP; (2016) 'Cyclization of 4-Phenoxy-2-coumarins and 2-Pyrones via a Double C-H Activation'. Organic letters, 18 (11) [DOI] [Details] | |
| (2016) | 'Molecular Signature of Pseudomonas aeruginosa with Simultaneous Nanomolar Detection of Quorum Sensing Signaling Molecules at a Boron-Doped Diamond Electrode' Buzid, A.,Shang, F.,Reen, F. J.,Muimhneachain, E. O.,Clarke, S. L.,Zhou, L.,Luong, J. H.,O'Gara, F.,McGlacken, G. P.,Glennon, J. D. (2016) 'Molecular Signature of Pseudomonas aeruginosa with Simultaneous Nanomolar Detection of Quorum Sensing Signaling Molecules at a Boron-Doped Diamond Electrode'. Sci Rep, 6 [DOI] [Details] | |
| (2016) | 'Synthesis and electrochemical detection of a thiazolyl-indole natural product isolated from the nosocomial pathogen Pseudomonas aeruginosa' Buzid, A.,Muimhneachain, E. O.,Reen, F. J.,Hayes, P. E.,Pardo, L. M.,Shang, F.,O'Gara, F.,Sperry, J.,Luong, J. H.,Glennon, J. D.,McGlacken, G. P. (2016) 'Synthesis and electrochemical detection of a thiazolyl-indole natural product isolated from the nosocomial pathogen Pseudomonas aeruginosa'. Anal Bioanal Chem, 408 (23):6361-7 [DOI] [Details] | |
| (2016) | 'Palladium(II) oxide impregnated on magnetite as a catalyst for the synthesis of 4-arylcoumarins via a Heck-arylation/cyclization process' Perez, JM;Cano, R;McGlacken, GP;Ramon, DJ (2016) 'Palladium(II) oxide impregnated on magnetite as a catalyst for the synthesis of 4-arylcoumarins via a Heck-arylation/cyclization process'. RSC Advances, 6 :36932-36941 [DOI] [Details] | |
| (2016) | 'Impregnated palladium on magnetite as catalyst for direct arylation of heterocycles' Cano, R;Perez, JM;Ramon, DJ;McGlacken, GP (2016) 'Impregnated palladium on magnetite as catalyst for direct arylation of heterocycles'. Tetrahedron, 72 :1043-1050 [DOI] [Details] | |
| (2016) | 'Exploiting Interkingdom Interactions for Development of Small-Molecule Inhibitors of Candida albicans Biofilm Formation' Reen, F. J.,Phelan, J. P.,Gallagher, L.,Woods, D. F.,Shanahan, R. M.,Cano, R.,O. Muimhneachain E,McGlacken, G. P.,O'Gara, F. (2016) 'Exploiting Interkingdom Interactions for Development of Small-Molecule Inhibitors of Candida albicans Biofilm Formation'. Antimicrob Agents Chemother, 60 (10):5894-905 [DOI] [Details] | |
| (2015) | 'Pd/Pivalic Acid Mediated Direct Arylation of 2-Pyrones and Related Heterocycles' Pardo, LM;Prendergast, AM;Nolan, MT;Muimhneachain, EO;McGlacken, GP (2015) 'Pd/Pivalic Acid Mediated Direct Arylation of 2-Pyrones and Related Heterocycles'. European Journal of Organic Chemistry, :3540-3550 [DOI] [Details] | |
| (2015) | 'Asymmetric Aldol-Tishchenko Reaction of Sulfinimines' Foley, VM;McSweeney, CM;Eccles, KS;Lawrence, SE;McGlacken, GP (2015) 'Asymmetric Aldol-Tishchenko Reaction of Sulfinimines'. Organic letters, 17 :5642-5645 [DOI] [Details] | |
| (2015) | 'A structure activity-relationship study of the bacterial signal molecule HHQ reveals swarming motility inhibition in Bacillus atrophaeus' Reen, F. J.,Shanahan, R.,Cano, R.,O'Gara, F.,McGlacken, G. P. (2015) 'A structure activity-relationship study of the bacterial signal molecule HHQ reveals swarming motility inhibition in Bacillus atrophaeus'. Org Biomol Chem, 13 (19):5537-41 [DOI] [Details] | |
| (2015) | 'Direct arylation and heterogeneous catalysis; ever the twain shall meet' Cano, R;Schmidt, AF;McGlacken, GP (2015) 'Direct arylation and heterogeneous catalysis; ever the twain shall meet'. Chemical Science, 6 :5338-5346 [DOI] [Details] | |
| (2015) | 'Pd/Pivalic Acid Mediated Direct Arylation of 2-Pyrones and Related Heterocycles' Pardo, LM,Prendergast, AM,Nolan, MT,Muimhneachain, EO,McGlacken, GP (2015) 'Pd/Pivalic Acid Mediated Direct Arylation of 2-Pyrones and Related Heterocycles'. European Journal of Organic Chemistry, :3540-3550 [DOI] [Details] | |
| (2015) | 'Access to trifluoromethylated 4-alkoxy-2-pyrones, pyridones and quinolones' Clarke, SL,McGlacken, GP (2015) 'Access to trifluoromethylated 4-alkoxy-2-pyrones, pyridones and quinolones'. Tetrahedron, 71 :2906-2913 [DOI] [Details] | |
| (2014) | 'The asymmetric alkylation of dimethylhydrazones; intermolecular chirality transfer using sparteine as chiral ligand' McSweeney, CM;Foley, VM;McGlacken, GP (2014) 'The asymmetric alkylation of dimethylhydrazones; intermolecular chirality transfer using sparteine as chiral ligand'. Chemical Communications, 50 :14817-14819 [DOI] [Details] | |
| (2014) | 'One step preparation and electrochemical analysis of IQS, a cell-cell communication signal in the nosocomial pathogen Pseudomonas aeruginosa' Shang, F,Muimhneachain, EO,Reen, FJ,Buzid, A,O'Gara, F,Luong, JHT,Glennon, JD,McGlacken, GP (2014) 'One step preparation and electrochemical analysis of IQS, a cell-cell communication signal in the nosocomial pathogen Pseudomonas aeruginosa'. Bioorganic & Medicinal Chemistry Letters, 24 :4703-4707 [DOI] [Details] | |
| (2014) | 'The asymmetric alkylation of dimethylhydrazones; intermolecular chirality transfer using sparteine as chiral ligand' McSweeney, CM,Foley, VM,McGlacken, GP (2014) 'The asymmetric alkylation of dimethylhydrazones; intermolecular chirality transfer using sparteine as chiral ligand'. Chemical Communications, 50 :14817-14819 [DOI] [Details] | |
| (2014) | 'Stability, oxidation and shape evolution of PVP-capped Pd nanocrystals' Collins, G.; Schmidt, M.; McGlacken, G. P.; O’Dwyer, C.; Holmes, J. D. (2014) 'Stability, oxidation and shape evolution of PVP-capped Pd nanocrystals'. Journal of Physical Chemistry C, 118 (12):6522-6530 [DOI] [Full Text] [Details] | |
| (2014) | 'Aspirated bile: a major host trigger modulating respiratory pathogen colonisation in cystic fibrosis patients' Reen, FJ,Woods, DF,Mooij, MJ,Chroinin, MN,Mullane, D,Zhou, L,Quille, J,Fitzpatrick, D,Glennon, JD,McGlacken, GP,Adams, C,O'Gara, F (2014) 'Aspirated bile: a major host trigger modulating respiratory pathogen colonisation in cystic fibrosis patients'. European Journal of Clinical Microbiology & Infectious Diseases, 33 :1763-1771 [DOI] [Details] | |
| (2014) | 'Aspirated bile: a major host trigger modulating respiratory pathogen colonisation in cystic fibrosis patients' Reen, F. J.,Woods, D. F.,Mooij, M. J.,Chroinin, M. N.,Mullane, D.,Zhou, L.,Quille, J.,Fitzpatrick, D.,Glennon, J. D.,McGlacken, G. P.,Adams, C.,O'Gara, F. (2014) 'Aspirated bile: a major host trigger modulating respiratory pathogen colonisation in cystic fibrosis patients'. Eur J Clin Microbiol Infect Dis, 33 (10):1763-71 [DOI] [Details] | |
| (2014) | 'The origin of shape sensitivity in palladium-catalyzed Suzuki-Miyaura cross coupling reactions' Collins, G.; Schmidt, M.; O’Dwyer, C.; Holmes, J. D.; McGlacken, G. P (2014) 'The origin of shape sensitivity in palladium-catalyzed Suzuki-Miyaura cross coupling reactions'. Angewandte Chemie International Edition, 53 (16):4142-4145 [DOI] [Full Text] [Details] | |
| (2014) | 'Pd-catalysed intramolecular regioselective arylation of 2-pyrones, pyridones, coumarins and quinolones by C-H bond functionalization' Nolan, MT;Bray, JTW;Eccles, K;Cheung, MS;Lin, ZY;Lawrence, SE;Whitwood, AC;Fairlamb, IJS;McGlacken, GP (2014) 'Pd-catalysed intramolecular regioselective arylation of 2-pyrones, pyridones, coumarins and quinolones by C-H bond functionalization'. Tetrahedron, 70 :7120-7127 [DOI] [Details] | |
| (2014) | 'Enhanced Catalytic Activity of High-Index Faceted Palladium Nanoparticles in Suzuki Miyaura Coupling Due to Efficient Leaching Mechanism' Collins, G,Schmidt, M,O'Dwyer, C,McGlacken, G,Holmes, JD (2014) 'Enhanced Catalytic Activity of High-Index Faceted Palladium Nanoparticles in Suzuki Miyaura Coupling Due to Efficient Leaching Mechanism'. ACS Catalysis, 4 :3105-3111 [DOI] [Details] | |
| (2014) | 'One step preparation and electrochemical analysis of IQS, a cell-cell communication signal in the nosocomial pathogen Pseudomonas aeruginosa' Shang F, Muimhneacháin EÓ, Reen FJ, Buzid A, O'Gara F, Luong JH, Glennon JD, McGlacken GP (2014) 'One step preparation and electrochemical analysis of IQS, a cell-cell communication signal in the nosocomial pathogen Pseudomonas aeruginosa'. Bioorganic and Medicinal Chemistry Letters, 24 (19):4703-4707 [DOI] [Details] | |
| (2014) | 'The Origin of Shape Sensitivity in Palladium-Catalyzed Suzuki-Miyaura Cross Coupling Reactions' Collins, G;Schmidt, M;Dwyer, CO;Holmes, JD;McGlacken, GP (2014) 'The Origin of Shape Sensitivity in Palladium-Catalyzed Suzuki-Miyaura Cross Coupling Reactions'. Angewandte Chemie International Edition, 53 :4142-4145 [DOI] [Details] | |
| (2013) | 'Semagacestat, a gamma-secretase inhibitor, activates the growth hormone secretagogue (GHS-R1a) receptor' Schellekens, H,McNamara, O,Dinan, TG,McCarthy, JV,McGlacken, GP,Cryan, JF (2013) 'Semagacestat, a gamma-secretase inhibitor, activates the growth hormone secretagogue (GHS-R1a) receptor'. Journal of Pharmacy and Pharmacology, 65 :528-538 [DOI] [Details] | |
| (2013) | 'Semagacestat, a ¿-secretase inhibitor, activates the growth hormone secretagogue (GHS-R1a) receptor' Schellekens H, McNamara O, Dinan TG, McCarthy JV, McGlacken GP, Cryan JF (2013) 'Semagacestat, a ¿-secretase inhibitor, activates the growth hormone secretagogue (GHS-R1a) receptor'. The Journal of pharmacy and pharmacology, 65 (4):528-538 [DOI] [Details] | |
| (2013) | 'Highly Stable PEGylated Gold Nanoparticles in Water: Applications in Biology and Catalysis' Rahme K., Nolan MT., Doody T., McGlacken GP., Morris MA., O’Driscoll C and Holmes JD. (2013) 'Highly Stable PEGylated Gold Nanoparticles in Water: Applications in Biology and Catalysis'. RSC Advances, 3 :21016-21024 [Details] | |
| (2013) | 'Highly stable PEGylated gold nanoparticles in water: applications in biology and catalysis' Rahme, K;Nolan, MT;Doody, T;McGlacken, GP;Morris, MA;O'Driscoll, C;Holmes, JD (2013) 'Highly stable PEGylated gold nanoparticles in water: applications in biology and catalysis'. RSC Advances, 3 :21016-21024 [DOI] [Details] | |
| (2012) | 'Semagacestat, a g-secretase inhibitor, activates the growth hormone secretagogue (GHS-R1a) receptor' Harriët Schellekensa, Orla McNamara, Timothy G. Dinana, Justin V. McCarthy, Gerard P. McGlacken and John F. Cryan (2012) 'Semagacestat, a g-secretase inhibitor, activates the growth hormone secretagogue (GHS-R1a) receptor'. Journal of Pharmacy and Pharmacology, [Details] | |
| (2012) | 'Analysis of pseudomonas quinolone signal and other bacterial signalling molecules using capillaries coated with highly charged polyelectrolyte monolayers and boron doped diamond electrode' Zhou, L,Reen, FJ,O'Gara, F,McSweeney, CM,Clarke, SL,Glennon, JD,Luong, JHT,McGlacken, GP (2012) 'Analysis of pseudomonas quinolone signal and other bacterial signalling molecules using capillaries coated with highly charged polyelectrolyte monolayers and boron doped diamond electrode'. Journal of chromatography. A, 1251 :169-175 [DOI] [Details] | |
| (2012) | 'Analysis of Pseudomonas quinolone signal and other bacterial signalling molecules using capillaries coated with highly charged polyelectrolyte monolayers and boron doped diamond electrode' Zhou, L.,Reen, F. J.,O'Gara, F.,McSweeney, C. M.,Clarke, S. L.,Glennon, J. D.,Luong, J. H.,McGlacken, G. P. (2012) 'Analysis of Pseudomonas quinolone signal and other bacterial signalling molecules using capillaries coated with highly charged polyelectrolyte monolayers and boron doped diamond electrode'. J Chromatogr A, 1251 :169-75 [DOI] [Details] | |
| (2012) | 'Structure-function analysis of the C-3 position in analogues of microbial behavioural modulators HHQ and PQS' Reen, FJ,Clarke, SL,Legendre, C,McSweeney, CM,Eccles, KS,Lawrence, SE,O'Gara, F,McGlacken, GP (2012) 'Structure-function analysis of the C-3 position in analogues of microbial behavioural modulators HHQ and PQS'. Organic & Biomolecular Chemistry, 10 :8903-8910 [DOI] [Details] | |
| (2012) | 'Structure-function analysis of the C-3 position in analogues of microbial behavioural modulators HHQ and PQS' Reen, F. J.,Clarke, S. L.,Legendre, C.,McSweeney, C. M.,Eccles, K. S.,Lawrence, S. E.,O'Gara, F.,McGlacken, G. P. (2012) 'Structure-function analysis of the C-3 position in analogues of microbial behavioural modulators HHQ and PQS'. Org Biomol Chem, 10 (44):8903-10 [DOI] [Details] | |
| (2012) | 'Pseudomonas aeruginosa Alkyl quinolones repress hypoxia-inducible factor 1 (HIF-1) signaling through HIF-1alpha degradation' Legendre, C.,Reen, F. J.,Mooij, M. J.,McGlacken, G. P.,Adams, C.,O'Gara, F. (2012) 'Pseudomonas aeruginosa Alkyl quinolones repress hypoxia-inducible factor 1 (HIF-1) signaling through HIF-1alpha degradation'. Infect Immun, 80 (11):3985-92 [DOI] [Details] | |
| (2011) | 'The Pseudomonas quinolone signal (PQS), and its precursor HHQ, modulate interspecies and interkingdom behaviour' Reen, F. J.,Mooij, M. J.,Holcombe, L. J.,McSweeney, C. M.,McGlacken, G. P.,Morrissey, J. P.,O'Gara, F. (2011) 'The Pseudomonas quinolone signal (PQS), and its precursor HHQ, modulate interspecies and interkingdom behaviour'. FEMS Microbiol Ecol, 77 (2):413-28 [DOI] [Details] | |
| (2011) | 'Detection of the Pseudomonas Quinolone Signal (PQS) by cyclic voltammetry and amperometry using a boron doped diamond electrode' Zhou, L;Glennon, JD;Luong, JHT;Reen, FJ;O'Gara, F;McSweeney, C;McGlacken, GP (2011) 'Detection of the Pseudomonas Quinolone Signal (PQS) by cyclic voltammetry and amperometry using a boron doped diamond electrode'. Chemical Communications, 47 :10347-10349 [DOI] [Details] | |
| (2011) | 'The Pseudomonas quinolone signal (PQS), and its precursor HHQ, modulate interspecies and interkingdom behaviour' Reen, FJ,Mooij, MJ,Holcombe, LJ,McSweeney, CM,McGlacken, GP,Morrissey, JP,O'Gara, F; (2011) 'The Pseudomonas quinolone signal (PQS), and its precursor HHQ, modulate interspecies and interkingdom behaviour'. Fems Microbiology Ecology, 77 :413-428 [DOI] [Details] | |
| (2011) | 'Detection of the Pseudomonas Quinolone Signal (PQS) by cyclic voltammetry and amperometry using a boron doped diamond electrode' Zhou, L.,Glennon, J. D.,Luong, J. H.,Reen, F. J.,O'Gara, F.,McSweeney, C.,McGlacken, G. P. (2011) 'Detection of the Pseudomonas Quinolone Signal (PQS) by cyclic voltammetry and amperometry using a boron doped diamond electrode'. Chem Commun (Camb), 47 (37):10347-9 [DOI] [Details] | |
| (2011) | 'Detection of the Pseudomonas Quinolone Signal (PQS) by cyclic voltammetry and amperometry using a boron doped diamond electrode' Zhou, L., Glennon, J.D., Luong, J.H.T., Reen, F.J., O'Gara, F., McSweeney, C., and McGlacken, G.P.; (2011) 'Detection of the Pseudomonas Quinolone Signal (PQS) by cyclic voltammetry and amperometry using a boron doped diamond electrode'. Chemical Communications, 47 (37):10347-10349 [DOI] [Details] | |
| (2011) | 'The Pseudomonas quinolone signal (PQS), and its precursor HHQ, modulate interspecies and interkingdom behaviour' Reen, F.J., Mooij, M.J., Holcombe, L.J., McSweeney, C.M., McGlacken, G.P., Morrissey, J.P., and O'Gara, F.; (2011) 'The Pseudomonas quinolone signal (PQS), and its precursor HHQ, modulate interspecies and interkingdom behaviour'. FEMS Microbiol Ecol, 77 (2):413-428 [DOI] [Details] | |
| (2010) | 'Synthesis of 3-halo-analogues of HHQ, subsequent cross-coupling and first crystal structure of Pseudomonas quinolone signal (PQS)' McGlacken, GP,McSweeney, CM,O'Brien, T,Lawrence, SE,Elcoate, CJ,Reen, FJ,O'Gara, F; (2010) 'Synthesis of 3-halo-analogues of HHQ, subsequent cross-coupling and first crystal structure of Pseudomonas quinolone signal (PQS)'. Tetrahedron, 51 :5919-5921 [DOI] [Details] | |
| (2017) | 'Methyl fluorosulfonyldifluoroacetate (MFSDA): An Underutilised Reagent for Trifluoromethylation' Dr. Sarah L. Clarke and Dr. Gerard P. McGlacken (2017) 'Methyl fluorosulfonyldifluoroacetate (MFSDA): An Underutilised Reagent for Trifluoromethylation'. Chemistry - A European Journal, [DOI] [Details] | |
| (2017) | 'Intramolecular Direct Arylation of 1,3-Diketone-Derived Enol Ethers in a Synthesis of Tricyclic Oxoisochromene Derivatives' Eoin Ó Muimhneacháin, Leticia M. Pardo, Lorraine M. Bateman, U. B. Rao Khandavilli, Simon E. Lawrence and Gerard P. McGlacken (2017) 'Intramolecular Direct Arylation of 1,3-Diketone-Derived Enol Ethers in a Synthesis of Tricyclic Oxoisochromene Derivatives'. Advanced Synthesis and Catalysis, [DOI] [Details] | |
| (2017) | 'Direct Asymmetric Alkylation of Ketones: Still Unconquered' Rafael Cano, Armen Zakarian, and Gerard P. McGlacken (2017) 'Direct Asymmetric Alkylation of Ketones: Still Unconquered'. Angewandte Chemie International Edition, [DOI] [Details] | |
| (2017) | 'Liquid-phase monolayer doping of InGaAs with Si-, S- and Sn-containing organic molecular layers' O’Connell, J.; Napolitani, E.; Impellizzeri, G.; Glynn, C.; McGlacken, G. P.; O’Dwyer, C.; Duffy, R.; Holmes, J. D. (2017) 'Liquid-phase monolayer doping of InGaAs with Si-, S- and Sn-containing organic molecular layers'. ACS Omega, 2 (5):1750-1759 [DOI] [Full Text] [Details] | |
| (2017) | 'The requirements at the C-3 position of alkylquinolones for signalling in Pseudomonas aeruginosa' Shanahan, Rachel; Reen, F. Jerry; Cano, Rafael; O'Gara, Fergal; McGlacken, Gerard P. (2017) 'The requirements at the C-3 position of alkylquinolones for signalling in Pseudomonas aeruginosa'. Organic & Biomolecular Chemistry, 15 :306-310 [DOI] [Full Text] [Details] | |
| (2016) | 'Exploiting Interkingdom Interactions for Development of Small-Molecule Inhibitors of Candida albicans Biofilm Formation' Reen, FJ;Phelan, JP;Gallagher, L;Woods, DF;Shanahan, RM;Cano, R;Muimhneachain, EO;McGlacken, GP;O'Gara, F (2016) 'Exploiting Interkingdom Interactions for Development of Small-Molecule Inhibitors of Candida albicans Biofilm Formation'. Antimicrobial Agents and Chemotherapy, 60 :5894-5905 [DOI] [Full Text] [Details] | |
| (2016) | 'Synthesis and electrochemical detection of a thiazolyl-indole natural product isolated from the nosocomial pathogen Pseudomonas aeruginosa' Buzid, Alyah; Muimhneacháin, Eoin Ó; Reen, F. Jerry; Hayes, Phyllis E.; Pardo, Leticia M.; Shang, Fengjun; O’Gara, Fergal; Sperry, Jonathan; Luong, John H. T.; Glennon, Jeremy D.; McGlacken, Gerard P. (2016) 'Synthesis and electrochemical detection of a thiazolyl-indole natural product isolated from the nosocomial pathogen Pseudomonas aeruginosa'. Analytical and Bioanalytical Chemistry, 408 (23):6361-6367 [DOI] [Full Text] [Details] | |
| (2016) | 'Molecular Signature of Pseudomonas aeruginosa with Simultaneous Nanomolar Detection of Quorum Sensing Signaling Molecules at a Boron-Doped Diamond Electrode' Buzid, A;Shang, FJ;Reen, FJ;Muimhneachain, EO;Clarke, SL;Zhou, L;Luong, JHT;O'Gara, F;McGlacken, GP;Glennon, JD (2016) 'Molecular Signature of Pseudomonas aeruginosa with Simultaneous Nanomolar Detection of Quorum Sensing Signaling Molecules at a Boron-Doped Diamond Electrode'. Scientific Reports, 6 [DOI] [Details] | |
| (2016) | 'A novel non-peptidic agonist of the ghrelin receptor with orexigenic activity in vivo' Pastor-Cavada, E; Pardo, LM; Kandil, D; Torres-Fuentes, C; Clarke, SL; Shaban, H;McGlacken, GP; Schellekens, H (2016) 'A novel non-peptidic agonist of the ghrelin receptor with orexigenic activity in vivo'. Scientific Reports, 6 :1-13 [DOI] [Full Text] [Details] | |
| (2016) | 'Monolayer doping of Si with improved oxidation resistance' O’Connell, J.; Collins, G.; McGlacken, G. P.; Duffy, R.; Holmes, J. D. (2016) 'Monolayer doping of Si with improved oxidation resistance'. ACS applied materials & interfaces, 8 (6):4101-4108 [DOI] [Full Text] [Details] | |
| (2016) | 'Cyclization of 4-Phenoxy-2-coumarins and 2-Pyrones via a Double C–H Activation' Katrina Mackey, Leticia M. Pardo, Aisling M. Prendergast, Marie-T. Nolan, Lorraine M. Bateman, and Gerard P. McGlacken (2016) 'Cyclization of 4-Phenoxy-2-coumarins and 2-Pyrones via a Double C–H Activation'. Organic letters, [DOI] [Details] | |
| (2016) | 'Palladium(II) oxide impregnated on magnetite as a catalyst for the synthesis of 4-arylcoumarins via a Heck-arylation/cyclization process' Juana M. Pérez, Rafael Cano, Gerard P. McGlacken and Diego J. Ramón (2016) 'Palladium(II) oxide impregnated on magnetite as a catalyst for the synthesis of 4-arylcoumarins via a Heck-arylation/cyclization process'. RSC Advances, 6 :36932-36941 [Details] | |
| (2016) | 'Monolayer Doping of Si with Improved Oxidation Resistance' O'Connell, J;Collins, G;McGlacken, GP;Duffy, R;Holmes, JD (2016) 'Monolayer Doping of Si with Improved Oxidation Resistance'. Acs Applied Materials & Interfaces, 8 :4101-4108 [DOI] [Details] | |
| (2016) | 'Impregnated palladium on magnetite as catalyst for direct arylation of heterocycles' Rafael Cano, Juana M. Pérez, Diego J. Ramón, Gerard P. McGlacken (2016) 'Impregnated palladium on magnetite as catalyst for direct arylation of heterocycles'. Tetrahedron, 72 [Details] | |
| (2015) | 'Organo-arsenic molecular layers on silicon for high density doping' O’Connell, J.; Alessio Verni, G.; Gangnaik, A.; Shayesteh, M.; Long, B.; Georgiev, Y. M.; Petkov, N.; McGlacken, G. P.; Morris, M. A.; Duffy, R.; Holmes, J. D. (2015) 'Organo-arsenic molecular layers on silicon for high density doping'. Acs Applied Materials & Interfaces, 7 (28):15514-15521 [DOI] [Full Text] [Details] | |
| (2015) | 'Asymmetric Aldol–Tishchenko Reaction of Sulfinimines' Vera M. Foley, Christina M. McSweeney, Kevin S. Eccles, Simon E. Lawrence, and Gerard P. McGlacken (2015) 'Asymmetric Aldol–Tishchenko Reaction of Sulfinimines'. Organic letters, [DOI] [Details] | |
| (2015) | 'Direct arylation and heterogeneous catalysis; ever the twain shall meet' Rafael Cano, Alexander F. Schmidt and Gerard P. McGlacken (2015) 'Direct arylation and heterogeneous catalysis; ever the twain shall meet'. Chemical Science, [DOI] [Details] | |
| (2015) | 'Access to trifluoromethylated 4-alkoxy-2-pyrones, pyridones and quinolones' Sarah L. Clarke, Gerard P. McGlacken (2015) 'Access to trifluoromethylated 4-alkoxy-2-pyrones, pyridones and quinolones'. Tetrahedron, 71 (19):2906-2913 [Details] | |
| (2015) | 'A structure activity-relationship study of the bacterial signal molecule HHQ reveals swarming motility inhibition in Bacillus atrophaeus' Reen, J., Shanahan, R., Cano, R., O’Gara, F., and McGlacken, G.P. (2015) 'A structure activity-relationship study of the bacterial signal molecule HHQ reveals swarming motility inhibition in Bacillus atrophaeus'. Organic and Biomolecular Chemistry, :5537-5541 [Full Text] [Details] | |
| (2015) | 'Pd/Pivalic Acid Mediated Direct Arylation of 2-Pyrones and Related Heterocycles' Leticia M. Pardo, Aisling M. Prendergast, Marie-T. Nolan, Eoin Ó Muimhneacháin and Gerard P. McGlacken (2015) 'Pd/Pivalic Acid Mediated Direct Arylation of 2-Pyrones and Related Heterocycles'. European Journal of Organic Chemistry, [DOI] [Details] | |
| (2015) | 'Intramolecular Direct Arylation of 3-Halo-2-pyrones and 2-Coumarins' Marie-T. Nolan, Leticia M. Pardo, Aisling M. Prendergast, and Gerard P. McGlacken (2015) 'Intramolecular Direct Arylation of 3-Halo-2-pyrones and 2-Coumarins'. Journal of Organic Chemistry, 80 (21):10904-10913 [DOI] [Details] | |
| (2014) | 'Stability, Oxidation, and Shape Evolution of PVP-Capped Pd Nanocrystals' Collins, Gillian and Schmidt, Michael and McGlacken, Gerard P. and O'Dwyer, Colm and Holmes, Justin D. (2014) 'Stability, Oxidation, and Shape Evolution of PVP-Capped Pd Nanocrystals'. Journal of Physical Chemistry C, 118 (12):6522-6530 [Details] | |
| (2014) | 'Investigation of a novel diamine based chiral auxiliary in the asymmetric alkylation of ketones' Clarke, SL,McSweeney, CM,McGlacken, GP (2014) 'Investigation of a novel diamine based chiral auxiliary in the asymmetric alkylation of ketones'. Tetrahedron-Asymmetry, 25 :356-361 [DOI] [Details] | |
| (2014) | 'Enhanced Catalytic Activity of High Index Faceted Palladium Nanoparticles in Suzuki-Miyaura Coupling due to Efficient Leaching Mechanism' Collins, G., Schmidt, M., O’Dwyer, C., McGlacken, G. & Holmes, J. D. (2014) 'Enhanced Catalytic Activity of High Index Faceted Palladium Nanoparticles in Suzuki-Miyaura Coupling due to Efficient Leaching Mechanism'. ACS Catalysis, 4 :3105-3111 [DOI] [Full Text] [Details] | |
| (2014) | 'The asymmetric alkylation of dimethylhydrazones; intermolecular chirality transfer using sparteine as chiral ligand' Christina McSweeney, Vera Foley, Gerard P. McGlacken (2014) 'The asymmetric alkylation of dimethylhydrazones; intermolecular chirality transfer using sparteine as chiral ligand'. Chem. Commun, 50 (94) [Details] | |
| (2014) | 'Pd-catalysed intramolecular regioselective arylation of 2-pyrones, pyridones, coumarins and quinolones by C–H bond functionalization' Marie-Therese Nolan, Joshua T.W. Bray, Kevin Eccles, Man Sing Cheung, Zhenyang Lin, Simon E. Lawrence, Adrian C. Whitwood, Ian J.S. Fairlamb, Gerard P. McGlacken (2014) 'Pd-catalysed intramolecular regioselective arylation of 2-pyrones, pyridones, coumarins and quinolones by C–H bond functionalization'. Tetrahedron, 70 (40) [Details] | |
| (2014) | 'One step preparation and electrochemical analysis of IQS, a cell-cell communication signal in the nosocomial pathogen Pseudomonas aeruginosa' F. Shang, E. O'Muimhneachain, F. Jerry Reen, A. Buzid, F. O'Gara, John H. T. Luong, J. D. Glennon, Gerard P. McGlacken (2014) 'One step preparation and electrochemical analysis of IQS, a cell-cell communication signal in the nosocomial pathogen Pseudomonas aeruginosa'. Bioorganic & Medicinal Chemistry Letters, 24 (19) [Details] | |
| (2014) | 'Aspirated bile: a major host trigger modulating respiratory pathogen colonisation in cystic fibrosis patients' Reen, F.J., Woods, D.F., Mooij, M.J., Chróinín, M.N., Mullane, D., Zhou, L., Quille, J., Fitzpatrick, D., Glennon, J.D., McGlacken. G.P., Adams, C., and O'Gara, F. (2014) 'Aspirated bile: a major host trigger modulating respiratory pathogen colonisation in cystic fibrosis patients'. European Journal of Clinical Microbiology & Infectious Diseases, 33 :1763-1771 [Details] | |
| (2013) | 'Highly stable PEGylated gold nanoparticles in water: applications in biology and catalysis' Rahme, K.; Nolan, M. T.; Doody, T.; McGlacken, G. P.; Morris, M. A.; O’Driscoll. C.; Holmes, J. D. (2013) 'Highly stable PEGylated gold nanoparticles in water: applications in biology and catalysis'. RSC Advances, 3 (43):21016-21024 [DOI] [Full Text] [Details] | |
| (2013) | 'Semagacestat, a gamma-secretase inhibitor, activates the growth hormone secretagogue (GHS-R1a) receptor' Schellekens, H.,McNamara, O.,Dinan, T. G.,McCarthy, J. V.,McGlacken, G. P.,Cryan, J. F. (2013) 'Semagacestat, a gamma-secretase inhibitor, activates the growth hormone secretagogue (GHS-R1a) receptor'. J Pharm Pharmacol, 65 (44):528-38528 [Details] | |
| (2012) | 'Structure–function analysis of the C-3 position in analogues of microbial behavioural modulators HHQ and PQS' Reen, F. Jerry; Clarke, Sarah L.; Legendre, Claire; McSweeney, Christina M.; Eccles, Kevin S.; Lawrence, Simon E.; O'Gara, Fergal; McGlacken, Gerard P (2012) 'Structure–function analysis of the C-3 position in analogues of microbial behavioural modulators HHQ and PQS'. Organic and Biomolecular Chemistry, 10 (44):8903-8910 [Details] | |
| (2012) | 'Analysis of pseudomonas quinolone signal and other bacterial signalling molecules using capillaries coated with highly charged polyelectrolyte monolayers and boron doped diamond electrode' Zhou, Lin; Reen, F. Jerry; O'Gara, Fergal; McSweeney, Christina M.; Clarke, Sarah L.; Glennon, Jeremy D.; Luong, John H. T.; McGlacken, Gerard P. (2012) 'Analysis of pseudomonas quinolone signal and other bacterial signalling molecules using capillaries coated with highly charged polyelectrolyte monolayers and boron doped diamond electrode'. Journal of Chromatography A, 1251 :169-175 [Details] | |
| (2012) | 'Pseudomonas aeruginosa alkyl quinolones repress hypoxia-inducible factor 1 (HIF-1) signaling through HIF-1α degradation' Legendre, Claire; Reen, F. Jerry; Mooij, Marlies J.; McGlacken, Gerard P.; Adams, Claire; O'Gara, Fergal (2012) 'Pseudomonas aeruginosa alkyl quinolones repress hypoxia-inducible factor 1 (HIF-1) signaling through HIF-1α degradation'. Infection and Immunity, 80 (11):3985-3992 [Details] | |
| (2011) | 'Detection of Pseudomonas Quinolone Signal (PQS) by cyclic voltammetry and amperometry using a boron doped diamond electrode' Zhou, L., Glennon, J. D., Luong, J. H. T., Reen, F. J., O¿Gara, F., McSweeney, C. and *McGlacken, G. P. (2011) 'Detection of Pseudomonas Quinolone Signal (PQS) by cyclic voltammetry and amperometry using a boron doped diamond electrode'. Chem. Commun, [Details] | |
| (2011) | 'The Pseudomonas Quinolone Signal (PQS), and its precursor HHQ, modulate interspecies and interkingdom behaviour' F.J. Reen, M.J. Mooij, L.J. Holcombe, C.M. McSweeney, G.P. McGlacken, J.P. Morrissey and F. O'Gara; (2011) 'The Pseudomonas Quinolone Signal (PQS), and its precursor HHQ, modulate interspecies and interkingdom behaviour'. FEMS Microbiol Ecol, [DOI] [Details] | |
| (2011) | 'Alkoxy‒arene cleavage using Ni catalysis' Gerard P. McGlacken and Sarah L. Clarke; (2011) 'Alkoxy‒arene cleavage using Ni catalysis'. ChemCatChem, [DOI] [Details] | |
| (2010) | 'Synthesis of 3-halo-analogues of HHQ, subsequent cross-coupling and first crystal structure of Pseudomonas quinolone signal (PQS)' McGlacken, Gerard P; McSweeney, Christina M; O'Brien, Timothy; Lawrence, Simon E; Elcoate, Curtis J; Reen, Jerry F; O'Gara, Fergal; (2010) 'Synthesis of 3-halo-analogues of HHQ, subsequent cross-coupling and first crystal structure of Pseudomonas quinolone signal (PQS)'. Tetrahedron Letters, 51 (45):5919-5921 [Details] | |
| (2009) | 'Recent advances in aryl-aryl bond formation by direct arylation' McGlacken, Gerard P. and Bateman, Lorraine M.; (2009) 'Recent advances in aryl-aryl bond formation by direct arylation'. CHEMICAL SOCIETY REVIEWS, 38 (8):2447-2464 [DOI] [Details] | |
| (2009) | 'Palladium-Catalysed Cross-Coupling and Related Processes: Some Interesting Observations That Have Been Exploited in Synthetic Chemistry' McGlacken, Gerard P. and Fairlamb, Ian J. S.; (2009) 'Palladium-Catalysed Cross-Coupling and Related Processes: Some Interesting Observations That Have Been Exploited in Synthetic Chemistry'. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, (24):4011-4029 [DOI] [Details] | |
| (2008) | 'Formation of carbanions using neutral organic molecules as electron-transfer reagents: A radical concept' McGlacken, Gerard P. and Khan, Tanweer A.; (2008) 'Formation of carbanions using neutral organic molecules as electron-transfer reagents: A radical concept'. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 47 (10):1819-1823 [DOI] [Details] | |
| (2007) | 'Chiral mono- and bis-annelated cyclopentadienyl ligands derived from tartaric acid: Synthesis of [(eta(5)-cyclopentadienyl)RuCl(cod)] and [(eta(5)-cyclopentadienyl)(eta(6)-benzene)Ru]PF6 derivatives' McGlacken, Gerard P. and O'Brien, Ciara T. and Whitwood, Adrian C. and Fairlamb, Ian J. S.; (2007) 'Chiral mono- and bis-annelated cyclopentadienyl ligands derived from tartaric acid: Synthesis of [(eta(5)-cyclopentadienyl)RuCl(cod)] and [(eta(5)-cyclopentadienyl)(eta(6)-benzene)Ru]PF6 derivatives'. ORGANOMETALLICS, 26 (15):3722-3728 [DOI] [Details] | |
| (2006) | 'Ruthenium(II)-catalysed cycloisomerisation of 1,6-dienes by focused microwave dielectric heating: improved rates and selectivities leading to exo-methylenecyclopentanes' Fairlamb, IJS and McGlacken, GP and Weissberger, F; (2006) 'Ruthenium(II)-catalysed cycloisomerisation of 1,6-dienes by focused microwave dielectric heating: improved rates and selectivities leading to exo-methylenecyclopentanes'. CHEMICAL COMMUNICATIONS, (9):988-990 [DOI] [Details] | |
| (2006) | 'Exploiting noninnocent (E,E)-dibenzylideneacetone (dba) effects in palladium(0)-mediated cross-coupling reactions: Modulation of the electronic properties of dba affects catalyst activity and stability in ligand and ligand-free reaction systems' Fairlamb, Ian J. S. and Kapdi, Anant R. and Lee, Adam F. and McGlacken, Gerard P. and Weissburger, Felix and de Vries, Andre H. M. and Schmieder-van de Vondervoort, Lizette; (2006) 'Exploiting noninnocent (E,E)-dibenzylideneacetone (dba) effects in palladium(0)-mediated cross-coupling reactions: Modulation of the electronic properties of dba affects catalyst activity and stability in ligand and ligand-free reaction systems'. CHEMISTRY-A EUROPEAN JOURNAL, 12 (34):8750-8761 [DOI] [Details] | |
| (2005) | 'A highly enantioselective, moderately anti-selective aldol reaction using a novel hydrazone moiety as stereo director' McGlacken, GP and Breeden, SW; (2005) 'A highly enantioselective, moderately anti-selective aldol reaction using a novel hydrazone moiety as stereo director'. TETRAHEDRON-ASYMMETRY, 16 (22):3615-3618 [DOI] [Details] | |
| (2005) | '2-Pyrone natural products and mimetics: isolation, characterisation and biological activity' McGlacken, GP and Fairlamb, IJS; (2005) '2-Pyrone natural products and mimetics: isolation, characterisation and biological activity'. NATURAL PRODUCT REPORTS, 22 (3):369-385 [DOI] [Details] |
Book Chapters
| Year | Publication | |
|---|---|---|
| (2015) | 'Pd Nanoparticles as Catalysts in Cross-coupling Reactions and the Homogeneous vs. Heterogeneous Debate' Eoin O Muimhneachain and Gerard P. McGlacken (2015) 'Pd Nanoparticles as Catalysts in Cross-coupling Reactions and the Homogeneous vs. Heterogeneous Debate' In: Organometallic Chemistry. London: RSC. [Details] | |
| (2009) | 'Recent Advances in Direction Arlyation via C-H activation' G.P. McGlacken; (2009) 'Recent Advances in Direction Arlyation via C-H activation' In: Organometallic Chemsitry. Cambridge: RSC. [Details] |
Reviews
| Year | Publication | |
|---|---|---|
| (2020) | Organolithium Bases in Flow Chemistry: A Review. Power, M;Alcock, E;McGlacken, GP (2020) Organolithium Bases in Flow Chemistry: A Review. WASHINGTON: Reviews [DOI] [Details] | |
| (2019) | The emergence of Pd-mediated reversible oxidative addition in cross coupling, carbohalogenation and carbonylation reactions. Jones, DJ;Lautens, M;McGlacken, GP (2019) The emergence of Pd-mediated reversible oxidative addition in cross coupling, carbohalogenation and carbonylation reactions. LONDON: Reviews [DOI] [Details] | |
| (2018) | Analogues of Pseudomonas aeruginosa signalling molecules to tackle infections. Muimhneachain, EO;Reen, FJ;O'Gara, F;McGlacken, GP (2018) Analogues of Pseudomonas aeruginosa signalling molecules to tackle infections. CAMBRIDGE: Reviews [DOI] [Details] | |
| (2018) | Transition Metal Mediated C-H Activation of 2-Pyrones, 2-Pyridones, 2-Coumarins and 2-Quinolones. Prendergast, AM;McGlacken, GP (2018) Transition Metal Mediated C-H Activation of 2-Pyrones, 2-Pyridones, 2-Coumarins and 2-Quinolones. WEINHEIM: Reviews [DOI] [Details] | |
| (2018) | Recent advances in manganese-catalysed C-H activation: scope and mechanism. Cano, R;Mackey, K;McGlacken, GP (2018) Recent advances in manganese-catalysed C-H activation: scope and mechanism. CAMBRIDGE: Reviews [DOI] [Details] | |
| (2018) | The expanding horizon of alkyl quinolone signalling and communication in polycellular interactomes. Reen, FJ;McGlacken, GP;O'Gara, F (2018) The expanding horizon of alkyl quinolone signalling and communication in polycellular interactomes. OXFORD: Reviews [DOI] [Details] | |
| (2017) | Direct Asymmetric Alkylation of Ketones: Still Unconquered. Cano, R;Zakarian, A;McGlacken, GP (2017) Direct Asymmetric Alkylation of Ketones: Still Unconquered. WEINHEIM: Reviews [DOI] [Details] | |
| (2017) | Methyl fluorosulfonyldifluoroacetate (MFSDA): An Underutilised Reagent for Trifluoromethylation. Clarke, SL;McGlacken, GP (2017) Methyl fluorosulfonyldifluoroacetate (MFSDA): An Underutilised Reagent for Trifluoromethylation. WEINHEIM: Reviews [DOI] [Details] | |
| (2015) | Direct arylation and heterogeneous catalysis; Ever the twain shall meet. Cano R.;Schmidt A.;McGlacken G. (2015) Direct arylation and heterogeneous catalysis; Ever the twain shall meet. Reviews [DOI] [Details] | |
| (2009) | Recent advances in aryl-aryl bond formation by direct arylation. McGlacken, GP;Bateman, LM (2009) Recent advances in aryl-aryl bond formation by direct arylation. CAMBRIDGE: Reviews [DOI] [Details] | |
| (2009) | Palladium-Catalysed Cross-Coupling and Related Processes: Some Interesting Observations That Have Been Exploited in Synthetic Chemistry. McGlacken, GP;Fairlamb, IJS (2009) Palladium-Catalysed Cross-Coupling and Related Processes: Some Interesting Observations That Have Been Exploited in Synthetic Chemistry. WEINHEIM: Reviews [DOI] [Details] |
Professional Activities
Honours and Awards
| Year | Title | Awarding Body | |
|---|---|---|---|
| 2005 | Molecular Design and Synthesis Postdoctoral Fellowship | Florida State University |
Conference Contributions
| Year | Publication | |
|---|---|---|
| (2014) | 8th Asian-European symposium on metal-mediated efficient organic synthesis, Gerard P. McGlacken (2014) 8th Asian-European symposium on metal-mediated efficient organic synthesis. [Invited Lectures (Conference)], 8th Asian-European symposium on metal-mediated efficient organic synthesis, Izmir, Turkey , 07-SEP-14 - 10-SEP-14. [Details] | |
| (2014) | 2nd International Symposium on C-H Activation, Gerard P. McGlacken (2014) 2nd International Symposium on C-H Activation. [Invited Lectures (Conference)], 2nd International Symposium on C-H Activation, Rennes, France , 30-JUN-14 - 03-JUL-14. [Details] | |
| (2013) | MRS Meeting, Collins, G., Schmidt, M., McGlacken, G., O'Dwyer, C. and Holmes, J. D. (2013) Probing the Origin of Structure Sensitivity and Facet Dependent Reactivity of Palladium Nanocatalysts in Carbon-Carbon Coupling Reactions. [Oral Presentation], MRS Meeting, Boston MA, USA . [Details] | |
| (2013) | OMCOS17, McGlacken, G. P., Collins, G., Schmidt, M., O’Dwyer, C., Moynihan, H., deVries, K. M., May, S. A. and Holmes, J. D. (2013) Pd Nanoparticles Possessing Distinctive Facet Architecture and their Catalytic Activity in Suzuki-Miyaura Reactions. [Poster Presentation], OMCOS17, Fort Collins, Colorado, USA . [Details] |
Teaching Activities
Teaching Interests
Dr McGlacken has a keen interest in the 'Research of Teaching' and treating Teaching as a discipline in itself. This has motivated him to complete a Certificate in 'Teaching and Learning in Higher Education' and he is currently undertaking a Higher Diploma in 'Teaching and Learning in Higher Education'.
He teaches on:
CM1000 Introduction to Chemistry, which includes: Fundamental and Inorganic Chemistry: elements and compounds, structure of atoms, chemical bonding, the Periodic Table, structures of compounds and chemistry of selected elements and groups. Physical Chemistry: states of matter, energetics, solutions, equilibria, kinetics, acids and basis. Organic Chemistry: historical aspects, functional groups and classes of compounds, reaction mechanisms, functional group interconversions.
CM2006 Aromatics, Carbonyls and Alkenes, which includes: Structure, synthesis, and reactivity of aromatic compounds. Synthesis, structure and reactivity of carbonyl compounds - tautomerism, nucleophilic addition, aldol, and related condensation reactions. Reactions of alpha, beta -unsaturated carbonyl compounds. Polymerisation of alkenes under different conditions, molecular and bulk properties of polymers, industrial polymers.
CM3101 Natural Products and Reaction Mechanisms, which includes: Molecular Rearrangements. Natural Product Chemistry: classification of biological molecules on the basis of chemical structure, (carbohydrates, terpenes, etc.).
CM3022 Synthesis, Structure and Reactivity of Organic Compounds, which includes: Synthesis, structure and reactions of heterocyclic aromatic compounds including pyrrole, furan, thiophene, pyridine, pyridine N-oxide, indole quinoline and isoquinoline. Functional group chemistry of organosulphur and organophosphorus compounds. Structure and reactivity of free radicals, carbenes, nitrenes and benzynes. Introduction to the design of organic synthesis; disconnections, synthons and synthetic equivalents and survey of synthetic methods. Functional group chemistry based on oxygen and nitrogen. Advanced stereochemistry. Amino acids and related compounds. Advanced 1H NMR spectroscopy. Introduction to 13C NMR. Mass spectrometry of organic compounds).
CM4101 Physical Organic Chemistry, which includes: Review of relevant mechanistic and kinetics material, linear free energy relationships, isotope effects, kinetic versus thermodynamic control, catalysis, medium effects, bio-organic mechanisms. Essentials of QSAR, structure-reactivity principle, Hammond postulate).
He has previously taught on NU2047, CM1003, CM1005, CM3001, CM3004.
He also tutors on CM4022 Advanced Organic Synthesis, Biosynthesis and Reactivity, which includes: Modern synthetic methods, photochemical reactions of organic compounds, organophosphorus, sulphur, selenium and palladium reagents; organic synthesis; design and strategy, retrosynthetic analysis, multistep partial and total synthesis; stereoselective reactions and asymmetric synthesis; chiral auxiliaries, reagents, catalysts; concerted pericyclic reactions; analysis base on orbital symmetry considerations; synthesis and reactions of heterocyclic compounds; natural products chemistry;biosynthesis and chemical transformations; structure reactivity relationships in organic chemistry).
Dr McGlacken served as Second Year Coordinator from 2009 - 2013 and is currently the Module Coordinator for CM2006, CM3022 and for the Final Year Project in the Chemistry of Pharmaceutical Compounds Degree (CM4203).