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Chemistry

Research Profiles

Dr Humphrey Moynihan BSc, PhD

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Dr Humphrey Moynihan BSc, PhD

Books

Humphrey Moynihan and Abina Crean; (2009) The Physicochemical Basis of Pharmaceuticals. Oxford: Oxford University Press. [Details]

Book Chapters

Humphrey A. Moynihan and Dawn M. Kelly (2012) 'Phenacetin Crystallization: Cooling Regimes and Crystal Morphology' In: Marcello Rubens Barsi Andreeta (eds). Crystallization Science and Technology. Croatia: InTech. [Details]
Humphrey A. Moynihan; (2005) 'Comprehensive Organic Functional Group Transformations' In: Alkyl Metals. Oxford: Elsevier. [Details]
 

Peer Reviewed Journals

Humphrey A. Moynihan, Ian Derrick, Jillian H. Broadbear, Benjamin M. Greedy, Mario D. Aceto, Louis S. Harris, Lauren C. S. Purington, Mark P. Thomas, James H. Woods, John R. Traynor, Stephen M. Husbands, and John W. Lewis (2012) 'Fumaroylamino-4,5-epoxymorphinans and Related Opioids with Irreversible mu Opioid Receptor Antagonist Effects'. Journal of Medicinal Chemistry, 55 :9868-9874. [Details]
John A. Hayes, Kevin S. Eccles, Simon E. Lawrence, Humphrey A. Moynihan (2012) 'Preparation and characterisation of solid state forms of paracetamol-O-glucuronide'. Carbohydrate Research, 349 :108-112. [Details]
Eccles, Kevin; Morrison, Robin; Stokes, Stephen; O'Mahony, Graham; Hayes, John; Kelly, Dawn; O'Boyle, Noel; Fabian, Laszlo; Moynihan, H.; Maguire, Anita; Lawrence, Simon E. (2012) 'Utilizing Sulfoxide...Iodine Halogen Bonding for Cocrystallization'. Crystal Growth and Design, 12 (6):2969-2977. [Full Text] [Details]
K.P. Guiry, J.M. Kelleher, S.E. Lawrence, M.T. McAuliffe, H.A. Moynihan and A.L. Ryan; (2007) 'Crystal polymorphism of pharmaceuticals: probing crystal nucleation at the molecular level'. J. Enz. Inhib. Med. Chem, 22 (5):550-555. [Details]
J.M. Kelleher, S.E. Lawrence, M.T. McAuliffe and H.A. Moynihan; (2007) 'Monomeric and polymeric derivatives of 5-aminoisophthalic acid as selective inhibitors of the beta-polymorph of L-glutamic acid'. CrystEngComm, 9 (1):72-77. [Details]
Fabian, Laszlo; Hamill, Noel; Eccles, Kevin; Moynihan, H.; Maguire, Anita; McCausland, Linda; Lawrence, Simon E; (2011) 'Cocrystals of fenamic acids with nicotinamide'. Crystal Growth and Design, 11 :3522-3528. [Details]
Eccles, KS,Stokes, SP,Daly, CA,Barry, NM,McSweeney, SP,O'Neill, DJ,Kelly, DM,Jennings, WB,Dhubhghaill, OMN,Moynihan, HA,Maguire, AR,Lawrence, SE; (2011) 'Evaluation of the Bruker SMART X2S: crystallography for the nonspecialist?'. Journal of Applied Crystallography, 44 :213-215. [DOI] [Full Text] [Details]
Moynihan, H; Kelly, Dawn; Eccles, Kevin; Elcoate, Curtis; Lawrence, Simon E; (2010) 'Crystal polymorphs and transformations of 2-iodo-4-nitroaniline'. Crystal Growth and Design, 10 :4303-4309. [DOI] [Details]
Moynihan, Humphrey A; Claudon, Geraldine; (2010) 'Direction of copper phthalocyanine crystallization using in situ generated tethered phthalocyanines'. CrystEngComm, . [DOI] [Details]
Kelly, Dawn M; Moynihan, Humphrey A; (2010) 'Synthesis and evaluation of fully (5-amidoisophthalic acid)- functionalised polyacrylamides as selective inhibitors of the beta crystal polymorph of L-glutamic acid'. Tetrahedron, . [DOI] [Details]
Lawrence, SE; McAuliffe, MT; Moynihan HA; (2010) 'Mimics of a R22(8) hydrogen-bond dimer motif: synthesis and influence on the crystallisation of sulfathiazole and sulfapyridine'. European Journal of Organic Chemistry, 6 :1134-1141. [Details]
Kivlehan, Francine; Lefoix, Myriam; Moynihan, Humphrey A; Thompson, Damien; Ogurtsov, Vladimir I; Herzog, Gregoire; Arrigan, Damien WM; (2010) 'Interaction of acridine-calix[4]arene with DNA at the electrified liqui|liquid interface'. Electrochimica Acta, 55 (9):3348-3354. [Details]
Francine Kivlehan, Wade J. Mace, Humphrey A. Moynihan*, Damien W. M. Arrigan; (2009) 'Study of electrochemical phosphate sensing systems: Spectrometric, potentiometric and voltammetric evaluation'. Electrochimica Acta, 54 :1919-1924. [Details]
H. Moynihan, A. R. Jules, B. M. Greedy, D. Rennison, J. H. Broadbear, L. Purington, J. R. Traynor, J. H. Woods, J. W. Lewis, and S. M. Husbands; (2009) '14beta-O-Cinnamoylnaltrexone and Related Dihydrocodeinones are Mu Opioid Partial Agonists with predominant Antagonist Activity'. Journal of medicinal chemistry, 52 (6):1553-1557. [Details]
, Grégoire Herzog, Brian McMahon, Myriam Lefoix, Nicholas D. Mullins, Courtney J. Collins, Humphrey A. Moynihan, Damien W. M. Arrigan; (2008) 'Electrochemistry of dopamine at the polarised liquid/liquid facilitated by an homo-oxo-calix[3]arene ionophore'. J. Electroanal. Chem, 622 (1):109-114. [Details]
Kevin P. Guiry, Simon J. Coles, Humphrey A. Moynihan, and Simon E. Lawrence; (2008) 'Effect of 1-Deoxy-D-lactose upon the Crystallization of D-Lactose'. Crystal Growth and Design, 10 . [Details]
Francine Kivlehan; Wade J. Mace; Humphrey A. Moynihan, Damien W. M. Arrigan; (2007) 'Potentiometric evaluation of calix[4]arene anion receptors in membrane electrodes: Phosphate detection'. Anal. Chim. Acta, 585 :154-160. [Details]
Joanne M. Kelleher, Marie T. McAuliffe, Humphrey A. Moynihan* and Nicholas D. Mullins; (2007) 'Studies on the preparation and crystal polymorphism of 2-acetamidobenzamide and related compounds'. ARKIVOC, (16):209-226. [Details]
, Joanne M. Kelleher, Simon E. Lawrence and Humphrey A. Moynihan; (2006) 'Effect of the steric demand and hydrogen bonding capacity of additives on the crystal polymorphism of sulfathiazole'. CrystEngComm, 8 :327-332. [Details]
Blackshields, C. A, Oliveira, J., Moynihan, H.A., Crean, A.M; (2006) 'Alginate-Chitosan Beads: Determining the Influence of Processing Parameters on Bead Formation'. J. Pharm. Pharmacol, Supplement 1 . [Details]
, Nick P. R. Nieland, Humphrey A. Moynihan, Simon Carrington, Jillian Broadbear, James H. Woods, John R. Traynor, Stephen M. Husbands*, and John W. Lewis; (2006) 'Structural Determinants of Opioid Activity in Derivatives of 14-Aminomorphinones: Effect of Substitution in the Aromatic Ring of Cinnamoylaminomorphinones and Codeinones'. J. Med. Chem, 49 (17):5333-5338. [Details]
David Rennison, Humphrey Moynihan, John R. Traynor, John W. Lewis, Stephen M. Husbands*,; (2006) 'Structural determinants of opioid activity in derivatives of 14-aminomorphinones: Effects of changes to the chain linking of the C-14-amino group to the aryl ring'. J. Med. Chem, 49 (20):6104-6110. [Details]
Patrick E. Hanrahan and Humphrey A. Moynihan; (2005) 'Preparation and stereochemical integrity of certain thioesters of 2-arylpropionic acids and related compounds'. J. Pharm. Pharmacol, 57 :1619-1627. [Details]
Muhammad N. Omar, Humphrey A. Moynihan and Richard J. Hamilton*,; (2003) 'Scaling-up the production of 13S-hydroxy-9Z,11E-octadecadienoic acid (13S-HODE) through chemoenzymatic technique'. Bulletin of the Korean Chemical Society, 24 (3):397-399. [Details]
Muhammad N. Omar, Humphrey A. Moynihan and Richard J. Hamilton; (2003) 'Asymmetric Sharpless epoxidation of 13S-hydroxy-9Z,11E-octadecadienoic acid'. European Journal of Lipid Science and Technology, 105 (1):43-44. [Details]
Muhammad Nor Bin Omar, Richard J. Hamilton and Humphrey A. Moynihan; (2003) 'Stereoselective preparations of epoxy-, fluoro- and related derivatives of ricinoleic acid and 13(S)-hydroxyoctadeca-9(Z),11(E)-dienoic acid'. ARKIVOC, (7):190-199. [Details]
, Humphrey. A. Moynihan* and Iain. P. O'Hare; (2002) 'Spectroscopic characterisation of orthorhombic and monoclinic paracetamol'. International Journal of Pharmaceutics, 247 :179-185. [Details]
M. J. Ingram, H. A. Moynihan*, M. W. Powell, C. Rostron; (2001) 'Synthesis and hydrolytic behaviour of glycerol-1,2-diibuprofenate-3-nitrate, a putative pro-drug of ibuprofen and glycerol-1-nitrate'. J. Pharm. Pharmacol, 53 :345-350. [Details]
Blackshields, C. A, Oliveira, J., Moynihan, H.A., Crean, A.M; (2006) 'Alginate-Chitosan Beads: Determining the Influence of Processing Parameters on Bead Formation'. Journal of Pharmacy and Pharmacology, * (Supplement 1):A49-*. [Details]
Guiry, K.P.; Kelleher, J.M.; Lawrence, S.E.; McAuliffe, M.T.; Moynihan, H.A; Ryan, A.L.;; (2007) 'Crystal polymorphism of pharmceuticals: probing crystal nucleation at the molecular level'. Journal of Enzyme Inhibition and Medicinal Chemistry, in press (*):*-*. [Details]
Collins C.C, Cronin M.F, Moynihan H.A, McCarthy D.G; (1997) 'Cyclisation of benzenesulfenyl chloride adducts with conjugated silyloxyenones: a new stereoselective reaction in the synthesis of 4,5-dihydrofuran-3(2H)-ones'. Journal of The Chemical Society, Perkin Transactions 1, * (*):1267-1269. [Details]
Madeline R. Whelan, Matthew J. Ingram, Claire Madden, James L. Ford*, Humphrey A. Moynihan; (2000) 'Compaction and thermal properties of a series of ibuprofen salts'. J.Pharm. Pharmacol, 52 (Supplement). [Details]
. J. Ingram, H. A. Moynihan*, M. W. Powell and C. Rostron; (1999) 'Hydrolysis of ibuprofen propyl ester in a physiologically-based model with direct analysis by reverse phase HPLC'. J. Pharm. Pharmacol, 51 (Supplement). [Details]
Humphrey A. Moynihan and WeipingYu,; (1998) 'Improved Selective Protections of L-Arginine'. Synthetic Communications, 28 :17-23. [Details]
, H. A. Moynihan* and W. Yu, ; (1998) 'Guanidino-substituted arginines via N-silyl intermediates'. J. Pharm. Pharmacol, 50 (Supplement) . [Details]
M. J. Ingram, H. A. Moynihan and C. Rostron, ; (1998) 'Synthesis and nitration of ibuprofen 1-monoglyceride'. J. Pharm. Pharmacol, 50 (Supplement) . [Details]
Humphrey A. Moynihan+ and Weiping Yu; (1998) 'Alkoxycarbonylation and Selective Deprotection of N-Silyl Derivatives of L-Arginine'. Tetrahedron Letters, 39 :3349-3352. [Details]
Conor C. Collins, Michael F. Cronin, Humphrey A. Moynihan and Daniel G. McCarthy; (1997) 'Cyclisations of Benzenesulfanyl Chloride Adducts with Conjugated Silyloxyenones: A New Stereoselective Reaction in the Synthesis of 4,5-Dihydro-3(2H)-Furanones'. J. Chem. Soc., Perkin Transactions 1, :1267-1269. [Details]
, Ian Derrick, John W. Lewis*, Humphrey A. Moynihan, Gillian Broadbear and James H. Woods; (1996) 'Potential Irreversible Ligands for Opioid Receptors. Cinnamoyl Derivatives of -Naltrexamine'. J. Pharm. Pharmacol, 48 :192-196. [Details]
Ian Derrick, Humphrey A. Moynihan and John W. Lewis; (1996) '6N-Cinnamoyl -Naltrexamine and its para-Nitro Derivatives. High Efficacy -Opiate Agonists with Weak Antagonist Action'. Bio-organic and Medicinal Chemistry Letters, 6 :167-172. [Details]
Neil G. Piggot, Ian Derrick, Humphrey A. Moynihan, Stephen M. Husbands, John W. Lewis* and James H. Woods; (1995) 'Molecular Modelling of Fumarimido and Cinnamoylamido Derivatives in Epoxy- Morphinans. Correlation with Pharmacological Profiles'. Analgesia, 1 :386-389. [Details]
C. J. Rhodes* and H. A. Moynihan; (2001) 'Self-reactivity of s-triazine and its radical cation: an electron/proton transfer process driven by ionizing radiation'. Magnetic Resonance in Chemistry, 39 (3):133-136. [Details]
Humphrey A. Moynihan, Stanley M. Roberts*, Hazel Weldon Graham H. Allcock, Erik E. Anggard and Timothy D. Warner; (1994) 'Synthesis and Biological Activity of the Novel Nitric Oxide Synthase Inhibitor N'-Hydroxy-N-methyl-L-arginine'. J. Chem. Soc.,Perkin Transactions 1, :769-771. [Details]
Christopher J. Rhodes*, Timothy C. Dintinger, Humphrey A. Moynihan and Ivan D. Reid, ; (2000) 'Spin-Labelling with the Second Hydrogen Radioisotope: Radicals Formed from Squalene by Muonium Addition'. Free Radical Research, 33 :75-79. [Details]
Humphrey A. Moynihan and Stanley M. Roberts; (1994) 'Preparation of Some Novel S-Nitroso Compounds as Potential Slow-release Agents of Nitric Oxide in vivo'. J. Chem. Soc.,Perkin Transactions 1, :797-805. [Details]
, Christopher J. Rhodes*, Timothy C. Dintinger and Humphrey A. Moynihan; (2000) 'Radiolabelling Studies of Free Radical Reactions using Muonium (the Second Hydrogen Radioisotope): Evidence of a Direct Antioxidant Role for Vitamin K in Repair of Oxidative Damage to Lipids'. Magnetic Resonance in Chemistry, 38 :646-649. [Details]
                                                                                                                                                                     
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