Orla Ni Dhubhghaill

Lecturer
Chemistry
Room 409
Department of Chemistry
Kane Building
University College Cork
Cork, Ireland

T: +353 21 490 2270
E: o.nidhubhghaill@ucc.ie

Orla Ni Dhubhghaill is a Lecturer in Inorganic Chemistry in UCC.  She obtained both B.Sc. (Hons) and Ph.D. degrees in chemistry from U.C.C. She spent six years as a Research Fellow at Birkbeck College, University of London, with Prof. P.J. Sadler, working on projects in the area of metal-based anticancer agents, followed by two years at the University of Lausanne, Switzerland, with Prof. A.E. Merbach, where she worked as a post-doctoral research associate on a project to investigate the relaxation properties of lanthanides used as Magnetic Resonance Imaging (MRI) contrast agents. In October 1994 she returned to UCC as a temporary lecturer in Inorganic Chemistry at UCC and was appointed to a permanent  Lectureship in October 1996.

Research Interests

Research in Orla Ni Dhubhghaill's laboratory is in the area of bioinorganic chemistry, in particular in the design and synthesis of coordination complexes with biological activity. The primary focus of recent research  has been on the design and synthesis of both platinum(II) and palladium(II) complexes with mixed N, P ligands with particular emphasis on imine derivatives.  Synthetic methodologies for a variety of P,N and P,N,O ligands, including amino acid derivatives,  have been successfully developed and their complexes synthesised.  In addition, investigations on the reactivities of these complexes towards biologically relevant species such as cysteine and methionine have been carried out.  

Most recently, we have developed routes to novel cycloplatinated compounds, including complexes of platinum(IV). Literature reports on other platinum(IV) complexes suggest that while these are not in themselves biologically active, in vivo reduction to the active platinum(II) species occurs, thus platinum(IV) compounds may be considered a type of inorganic `prodrug¿.  The potential of these compounds as anticancer agents is currently being assessed via DNA binding studies of selected compounds; preliminary results for these are promising.  Thus future research is directed towards design of analogues of these to assess the factors influencing their reactivity with DNA.  Also under investigation are charged derivatives of these and related compounds; preliminary results indicate that these have different  DNA binding properties and may act as intercalating agents.

Book Chapters

YearPublication
(1993)'Gold Complexes in Cancer Chemotherapy, a Review'
Ni Dhubhghaill, O.M.; Sadler,P.J.; (1993) 'Gold Complexes in Cancer Chemotherapy, a Review' In: Keppler, B.K (eds). Metal complexes in cancer chemotherapy. [No details]

Peer Reviewed Journals

YearPublication
(2011)'Evaluation of the Bruker SMART X2S: crystallography for the nonspecialist?'
Eccles, KS,Stokes, SP,Daly, CA,Barry, NM,McSweeney, SP,O'Neill, DJ,Kelly, DM,Jennings, WB,Dhubhghaill, OMN,Moynihan, HA,Maguire, AR,Lawrence, SE; (2011) 'Evaluation of the Bruker SMART X2S: crystallography for the nonspecialist?' [DOI] [Full Text] [Details]
(2005)'Palladium(II) and platinum(II) complexes with tridentate iminophosphine ligands; synthesis and structural studies'
Ni Dhubhghaill, OM; Lennon, J; Drew, MGB; (2005) 'Palladium(II) and platinum(II) complexes with tridentate iminophosphine ligands; synthesis and structural studies' [Details]
(2001)'Dichloro-trans-bis[tris(2- cyanoethyl)phosphine]palladium(II)]'
Lawrence, Simon E.; Kelly, Maureen; Ní Dhubhghaill, Orla M. ; (2001) 'Dichloro-trans-bis[tris(2- cyanoethyl)phosphine]palladium(II)]' [Details]
(1999)'Coordination equilibrium - a clue for fast water exchange on potential magnetic resonance imaging contrast agents?'
Toth, E; Ni Dhubhghaill, OM; Besson, G.;Helm, L; Merbach, A.E; (1999) 'Coordination equilibrium - a clue for fast water exchange on potential magnetic resonance imaging contrast agents?' [Details]
(1996)'Structural and Dynamic Parameters Obtained From ^17O NMR, EPR, and NMRD Studies of Monomeric and Dimeric Gd^3+ Complexes of Interest in Magnetic Resonance Imaging an Integrated and Theoretically Self-Consistent Approach [B4903]'
Powell, D. Hugh; Ni Dhubhghaill, Orla M.; Pubanz, Dirk; Helm, Lothar; Lebedev, Yakob S.; Schlaepfer, Willi; Merbach, Andre E.; (1996) 'Structural and Dynamic Parameters Obtained From ^17O NMR, EPR, and NMRD Studies of Monomeric and Dimeric Gd^3+ Complexes of Interest in Magnetic Resonance Imaging an Integrated and Theoretically Self-Consistent Approach [B4903]' [Details]
(1995)'Solution Kinetic Behaviour of Lanthanide (III) Polyaminocarboxylates From Oxygen-17 NMR Studies [B4905]'
Powell, D. H.; Favre, M.; Graeppi, N.; Ni Dhubhghaill, O. M.; Pubanz, D.; Merbach, A. E.; (1995) 'Solution Kinetic Behaviour of Lanthanide (III) Polyaminocarboxylates From Oxygen-17 NMR Studies [B4905]' [Details]
(1995)'Cytotoxic Phosphinarsino and Diphosphino Pd(II) Complexes of Thiolate Amino Acids and Glutathione [B4899]'
Ni Dhubhghaill, O. M.; Fernandez, E. G.; Sadler, P. J.; (1995) 'Cytotoxic Phosphinarsino and Diphosphino Pd(II) Complexes of Thiolate Amino Acids and Glutathione [B4899]' [Details]
(1994)'Aquation of the Anticancer Complex Trans-[Ru(III)Cl_4(Him)_2]-(Him = Imidazole) [B4901]'
Ni Dhubhghaill, O. M.; Hagen, W. R.; Keppler, B. K.; Lipponer, K.-G.; Sadler, P. J.; (1994) 'Aquation of the Anticancer Complex Trans-[Ru(III)Cl_4(Him)_2]-(Him = Imidazole) [B4901]' [Details]
(1993)'The Structure and Bonding in Nido-X_2B_9H_9 (X = S or Se) Clusters [B332]'
Ni Dhubhghaill, O.; Reed, D.; Spalding, T. R.; (1993) 'The Structure and Bonding in Nido-X_2B_9H_9 (X = S or Se) Clusters [B332]' [Details]
(1993)'Amphiphilic bisthiolato nickel(II), palladium(II), and platinum(II) complexes with bisphosphine or phosphinoarsino ligands'
Jarrett,P.S.; Ni Dhubhghaill,O.M.; Sadler,P.J.; (1993) 'Amphiphilic bisthiolato nickel(II), palladium(II), and platinum(II) complexes with bisphosphine or phosphinoarsino ligands' [Details]
(1992)'Drug induced reactions of bovine serum albumin: 1H NMR studies of gold binding and cysteine release'
Ni Dhubhghaill,O.M.; Sadler,P.J.;Tucker,A.; (1992) 'Drug induced reactions of bovine serum albumin: 1H NMR studies of gold binding and cysteine release' [Details]
(1991)'The structure and reactivity of arsenic compounds - biological-activity and drug design'
NiDhubhghaill, OM; Sadler, PJ, ; (1991) 'The structure and reactivity of arsenic compounds - biological-activity and drug design' [Details]
(1990)'Gold(I) complexes of 1-diphenylphosphino-2-diphenylarsinoethane (dadpe): Solution studies, X-ray crystal structures and cytotoxicity of [(AuCl2dadpe].0.5 DMA and [Au(dadpe)2]Cl.2H2O'
Ni Dhubhghaill,O.M.; Sadler, P.J.; Kuroda, R.; (1990) 'Gold(I) complexes of 1-diphenylphosphino-2-diphenylarsinoethane (dadpe): Solution studies, X-ray crystal structures and cytotoxicity of [(AuCl2dadpe].0.5 DMA and [Au(dadpe)2]Cl.2H2O' [Details]
(1989)'Metallaheteroborane Chemistry. Part 5. Synthesis of closo-[2,2-(PR)2-1,2- SePtB10H10].(R = Et3, Bun3, or Me2Ph) and arachno-[9,9-(PMe2Ph)2-6,9-SePtB8H10] and their characterisation by NMR techniques: The crystal and molecular structures of closo-[2,2-(PEt3)2-2,1-SePtB10H10] and arachno-[9,9-(PMe2Ph)2-6,9- SePtB8H10]'
Faridoon; Ni Dhubhghaill, O.M.; Spalding,T.R.; Ferguson,G.; Kaitner,B.; Fontaine,X.L.R.; Kennedy, J.D.; (1989) 'Metallaheteroborane Chemistry. Part 5. Synthesis of closo-[2,2-(PR)2-1,2- SePtB10H10].(R = Et3, Bun3, or Me2Ph) and arachno-[9,9-(PMe2Ph)2-6,9-SePtB8H10] and their characterisation by NMR techniques: The crystal and molecular structures of closo-[2,2-(PEt3)2-2,1-SePtB10H10] and arachno-[9,9-(PMe2Ph)2-6,9- SePtB8H10]' [Details]
(1989)'Studies of Group VI heteroboranes'
Ni Dhubhghaill,O.M.; MacCurtain,J.; Myers,M.; Spalding, T.R.; Brint, R.P; McCabe,T.; Ferguson,G.; Reed, D. G. Ferguson, and D. Reed; (1989) 'Studies of Group VI heteroboranes' [Details]
(1988)'Metallaheteroborane Chemistry - II. Synthesis and characterisation of [Ir(dppe)2(X)2][SeB10H11] {X = O (I), H (II)} complexes. Crystal and molecular structure of cis-bis[1,2-bis(diphenylphosphino)ethane]-dihydroiridium(III)selenaundecahydrodecaborate(1-), (II)'
Ferguson,G.; Hampden-Smith,M.J.; Ni Dhubhghaill,O.M.; Spalding,T.R.; (1988) 'Metallaheteroborane Chemistry - II. Synthesis and characterisation of [Ir(dppe)2(X)2][SeB10H11] {X = O (I), H (II)} complexes. Crystal and molecular structure of cis-bis[1,2-bis(diphenylphosphino)ethane]-dihydroiridium(III)selenaundecahydrodecaborate(1-), (II)' [Details]
(1988)'The formation of the [7-SeB10H11] anion from 1-SeB11H11 and the structure of the anion studied by boron-11 COSY NMR and X-ray crystallography'
Reed,D.; Ferguson,G.; Ruhl,B.L.;Ni Dhubhghaill, O.M.; Spalding, T.R.; (1988) 'The formation of the [7-SeB10H11] anion from 1-SeB11H11 and the structure of the anion studied by boron-11 COSY NMR and X-ray crystallography' [Details]
(1988)'Metallaheteroborane chemistry .4. The synthesis of closo-[2,2-(PPh3)2-2-H-1,2-XMB10H10] (X=Se or Te, M = Rh or Ir) compounds and arachno-[9,9-(PMe2Ph)2-6,9-SePtB8H10], their characterization by nuclear magnetic-resonance techniques and the crystal and molecular-structures of the X =Te, M=Rh complex'
Faridoon; Dhubhghaill, ON; Spalding, TR; Ferguson, G; Kaitner, B; Fontaine, XLR; Kennedy, JD; Reed, D.; (1988) 'Metallaheteroborane chemistry .4. The synthesis of closo-[2,2-(PPh3)2-2-H-1,2-XMB10H10] (X=Se or Te, M = Rh or Ir) compounds and arachno-[9,9-(PMe2Ph)2-6,9-SePtB8H10], their characterization by nuclear magnetic-resonance techniques and the crystal and molecular-structures of the X =Te, M=Rh complex' [Details]
(1987)'Reactions of heteroboranes. Synthesis of [2,2-(PPh3)2-2,1-SePtB10H10].CH2Cl2, its crystal and molecular structure and that of SeB11H11'
Ferguson, G.; Parvez, M.; McCurtain, J.A.; Ni Dhubhghaill,O.M.; Spalding, T.R; Reed, D.; (1987) 'Reactions of heteroboranes. Synthesis of [2,2-(PPh3)2-2,1-SePtB10H10].CH2Cl2, its crystal and molecular structure and that of SeB11H11' [Details]
(1987)'Structure and Mössbauer spectrum of bis(tetraethylammonium)1,1´-commo-bis(decahydro-1-ferra-2-selena-closo-decaborate)'
Ferguson,G.; Ruhl,B.L.; Ni Dhubhghaill,O.M.; Spalding, T.R.; (1987) 'Structure and Mössbauer spectrum of bis(tetraethylammonium)1,1´-commo-bis(decahydro-1-ferra-2-selena-closo-decaborate)' [Details]
(1982)'Preparation of a RuO2-modified semiconductor oxide surface- an optimisation procedure of interest in energy conversion systems'
Burke, L.D.; Healy, J.F.; Ni Dhubhghaill, O.M.; (1982) 'Preparation of a RuO2-modified semiconductor oxide surface- an optimisation procedure of interest in energy conversion systems' [Details]

Conference Contributions

YearPublication
(2008)60th Irish Universities Chemistry Research Colloquium,
Ni Dhubhghaill, Orla; (2008) Organisation of Research Colloquium. [Conference Organising Committee Chairperson], 60th Irish Universities Chemistry Research Colloquium, University College Cork , 11-JUN-08 - 13-JUN-08
(2007)5th Eli Lilly postgraduate research symposium,
Terence Maguire (Ph.D. student), Ni Dhubhghaill, Orla; (2007) Design and synthesis of novel Pt(II) and Pt(IV) tridentate complexes: potential anti-cancer agents. [Oral Presentation], 5th Eli Lilly postgraduate research symposium, University College Cork , 14-SEP-07 - 14-SEP-07
(2007)1st Irish Institute for Metal-Based Drugs meeting,
Ni Dhubhghaill, Orla; (2007) Palladium and Platinum Iminophosphines: potential anticancer agents. [Oral Presentation], 1st Irish Institute for Metal-Based Drugs meeting, Royal College of Surgeons, Dublin , 20-SEP-07 - 20-SEP-07
(2006)58th Irish Universities Research Colloquium,
Terence Maguire (Ph.D. student), Ni Dhubhghaill, Orla; (2006) Cycloplatinated imonophosphine complexes; synthesis and reactivity. [Oral Presentation], 58th Irish Universities Research Colloquium, NUIG, Galway , 14-JUN-06 - 16-JUN-06
(2006)Recent advances in synthesis and chemical biology V,
Ni Dhubhghaill, Orla; (2006) Cyclometallates; what drives their formation and how do they react?. [Poster Presentation], Recent advances in synthesis and chemical biology V, Royal College of Surgeons, Dublin , 15-DEC-06 - 15-DEC-06
(2006)COST D-20 Metal complexes in cancer and viral treatment - final meeting,
Ni Dhubhghaill, Orla; (2006) Synthesis and reactivity of novel cyclometallated complexes. [Poster Presentation], COST D-20 Metal complexes in cancer and viral treatment - final meeting, Brno, Czech Republic , 15-JUN-06 - 18-JUN-06
(2005)XX Congress of the International Union of Crystallography, IUCr,
Ni Dhubhghaill, Orla; (2005) Pd(II) and Pt(II) complexes with tridentate iminophosphine ligands and their phosphine derivatives. [Poster Presentation], XX Congress of the International Union of Crystallography, IUCr, Florence, Italy , 23-AUG-05 - 31-MAR-05
(2005)10th Irish Inorganic Chemistry Conference,
Ni Dhubhghaill, Orla; (2005) Palladium(II) and Platinum(II) Complexes with Tridentate Iminophosphine Ligands: Syntheses, Structural Studies, and Reactivity. [Poster Presentation], 10th Irish Inorganic Chemistry Conference, NUIM, Maynooth , 09-SEP-05 - 11-SEP-05
(2005)1st European Conference on Chemistry for Life Sciences,
Ni Dhubhghaill, Orla; (2005) Platinum and Palladium Iminophosphines: Synthesis, Structural Studies and Reaction with Nucleosides. [Poster Presentation], 1st European Conference on Chemistry for Life Sciences, Rimini, Italy , 04-OCT-05 - 08-OCT-05
(2004)Analytical & Biological Chemistry Research Facility research day,
J. Lennon, O.M. Ni Dhubhghaill, M.G.B. Drew ; (2004) Group 10 complexes of tridentate iminophosphines: syntheses, structures and reactivity. [Poster Presentation], Analytical & Biological Chemistry Research Facility research day, UCC , 22-APR-04 - 22-APR-04
(2003)55th Irish Universities Chemistry Research Colloquium,
Joanne Lennon (Ph.D. student), Ni Dhubhgaill, Orla; (2003) Palladium(II) and Platinum(II) complexes with tridentate iminophosphine ligands and their phosphine derivatives; synthesis and structural studies. [Oral Presentation], 55th Irish Universities Chemistry Research Colloquium, TCD, Dublin , 15-MAY-03 - 16-MAY-03

Committees

 CommitteeFunctionFrom / To
SEFS Academic Programmes and Curriculum Development (APCD) Committee Chemistry representative2010 / 2012
Bord na Gaeilge (UCC) Coopted member2010 /
Coiste Gno, Bord na Gaeilge (UCC) Member/
Teaching Committee, Chemistry department Examinations coordinator2007 / 2012
Research and graduate studies commitee, Chemistry Department Member2009 / 2012

Employment

 EmployerPositionFrom / To
University College Cork Lecturer01-OCT-96 /
University of Lausanne, Switzerland Research Associate01-JAN-93 / 01-SEP-94
Birkbeck College, University of London Research Fellow01-OCT-86 / 01-NOV-92

Education

 YearInstituionQualificationSubject
1983University College Cork BScChemistry
1988University College Cork PhDChemistry

Languages

 LanguageReadingWritingSpeaking
Irish FluentFluentFluent
French FunctionalFunctionalFunctional
German FunctionalFunctionalBasic

Reviews

 JournalRole
Journal Of Coordination Chemistry Referee

Teaching Interests

Teaching interests include the following topics taught from 2nd to final year undergraduate level. 

Coordination chemistry and transition element (TE) chemistryQualitative molecular orbital theorySpectroscopic methods in inorganic chemistryTransition elements in biological systems: metalloproteins and metallodrugs

Module coordinator of and lecturer on the following modules:  CM2008 (Covalent bonding and MO theory), CM3021 (TE chemistry and inorganic spectroscopy) 
Lecturer on the following modules:  CM1100 (History of atomic theory), CM2001 (Transition element chemistry),  CM4021 (Bioinorganic chemistry), CM4109 (Inorganic drugs ), and PF4001 (Metallodrugs).

Departmental Disability Support Services representative.

Chair of Departmental Teaching Committee.
 

Modules Taught

 Term (ID))TitleLinkSubject
2014Drug Design PF4001Drug Design
2014Inorganic Chemistry CM3021Inorganic Chemistry
2014Structure, Bonding and Quantum Mechanics CM2008Structure, Bonding and Quantum Mechanics