Research Profile

Gerardene Meade-Murphy

Biography

Dr. Gerardene Meade-Murphy graduated with her PhD at the Biochemistry Department, University College Cork (1999). In 2000, she took up a postdoctoral post with the platelet research group at the Department of Clinical Pharmacology, the Royal College of Surgeons in Ireland (RCSI, Dublin) and was awarded a Health Research Board grant in 2001 to study platelet adhesion in thrombosis. From 2005-2012, Gerardene worked on the development of clinical diagnostic assays of platelet function in cardiovascular disease, funded through two SFI-CSET programmes SFI-CSET at the Department of Molecular & Cellular Therapeutics (RCSI), and in affiliation with the Biomedical Diagnostics Institute (BDI, DCU). In 2012, she moved to the Centre for Preventative Medicine, School of Health & Human Performance, DCU, where she worked with the Vascular Research Group. From 2014-2015, Gerardene worked with the Translational Oncology Research Group, at the All Ireland Cooperative Oncology Research Group (ICORG, now Cancer Trials Ireland, Dublin) before taking a short career break. In February 2017, Gerardene took up her post as lecturer (part-time) at the Department of Pharmacology and Therapeutics, University College Cork. Her current work focuses on teaching into the BSc programme in Paramedic studies and establishing her research group in the area of Platelet and Cardiovascular Biology.

Publications

Peer Reviewed Journals

 YearPublication
(2017)'Moesin and merlin regulate urokinase receptor-dependent endothelial cell migration, adhesion and angiogenesis'
Bernard Degryse, Mishan Britto, Chun Xu Shan, Robert G. Wallace, Keith D. Rochfort, Philip M. Cummins, Gerardene Meade, Ronan P. Murphy (2017) 'Moesin and merlin regulate urokinase receptor-dependent endothelial cell migration, adhesion and angiogenesis'. The International Journal of Biochemistry & Cell Biology, 88 :14-22 [DOI] [Details]
(2013)'Assaying the efficacy of dual-antiplatelet therapy: use of a controlled-shear-rate microfluidic device with a well-defined collagen surface to track dynamic platelet adhesion'
Lucitt MB, O'Brien S, Cowman J, Meade G, Basabe-Desmonts L, Somers M, Kent N, Ricco AJ, Kenny D. (2013) 'Assaying the efficacy of dual-antiplatelet therapy: use of a controlled-shear-rate microfluidic device with a well-defined collagen surface to track dynamic platelet adhesion'. Analytical and Bioanalytical Chemistry, 405 (14):4823-4834 [DOI] [Details]
(2013)'Canonical Wnt signaling in megakaryocytes regulates proplatelet formation'
Macaulay IC, Thon JN, Tijssen MR, Steele BM, MacDonald BT, Meade G, Burns P, Rendon A, Salunkhe V, Murphy RP, Bennett C, Watkins NA, He X, Fitzgerald DJ, Italiano JE Jr, Maguire PB. (2013) 'Canonical Wnt signaling in megakaryocytes regulates proplatelet formation'. Blood, 121 (1):188-196 [DOI] [Details]
(2012)'Inhibition of platelet adhesion by peptidomimetics mimicking the interactive β-hairpin of glycoprotein Ibα'
Bernard E., Buckley V., Moman E., Coleman L., Meade G., Kenny D., Devocelle M. (2012) 'Inhibition of platelet adhesion by peptidomimetics mimicking the interactive β-hairpin of glycoprotein Ibα'. Bioorganic & Medicinal Chemistry Letters, 22 (9):3323-3326 [DOI] [Details]
(2012)'Effective Hydrodynamic Shaping of Sample Streams in a Microfluidic Parallel-Plate Flow-Assay Device: Matching Whole Blood Dynamic Viscosity'
Sinead O’Brien, Nigel J. Kent, Margaret Lucitt, Antonio J. Ricco, Colm McAtamney, Dermot Kenny, and Gerardene Meade (2012) 'Effective Hydrodynamic Shaping of Sample Streams in a Microfluidic Parallel-Plate Flow-Assay Device: Matching Whole Blood Dynamic Viscosity'. IEEE Transactions On Biomedical Engineering, 59 (2):374-382 [DOI] [Details]
(2011)'Shear-Mediated Platelet Adhesion Analysis in Less Than 100 μL of Blood: Toward a POC Platelet Diagnostic'
Nigel J. Kent*, Sinead O’Brien, Lourdes Basabe-Desmonts, Gerardene R. Meade, Brian D. MacCraith, Brian G. Corcoran, Dermot Kenny, and Antonio J. Ricco* (2011) 'Shear-Mediated Platelet Adhesion Analysis in Less Than 100 μL of Blood: Toward a POC Platelet Diagnostic'. IEEE Transactions On Biomedical Engineering, 58 (3):826-830 [DOI] [Details]
(2010)'Single-Step Separation of Platelets from Whole Blood Coupled with Digital Quantification by Interfacial Platelet Cytometry (iPC)'
L. Basabe-Desmonts†∥, S. Ramstrom‡∥, G. Meade‡, S. O’Neill‡, AL. Basabe-Desmonts†∥, S. Ramstrom‡∥, G. Meade‡, S. O’Neill‡, A. Riaz†, L. P. Lee*†§, A. J. Ricco*†, and D. Kenny*‡ (2010) 'Single-Step Separation of Platelets from Whole Blood Coupled with Digital Quantification by Interfacial Platelet Cytometry (iPC)'. Langmuir, 26 (18):14700-14706 [DOI] [Details]
(2010)'New trends in bioanalytical microdevices to assess platelet function'
Basabe-Desmonts L, Meade G, Kenny D. (2010) 'New trends in bioanalytical microdevices to assess platelet function'. Expert Review Of Molecular Diagnostics, 10 (7):869-874 [Details]
(2010)'Microfluidic device to study arterial shear-mediated platelet-surface interactions in whole blood: reduced sample volumes and well-characterised protein surfaces'
Kent NJ, Basabe-Desmonts L, Meade G, MacCraith BD, Corcoran BG, Kenny D and Ricco AJ. (2010) 'Microfluidic device to study arterial shear-mediated platelet-surface interactions in whole blood: reduced sample volumes and well-characterised protein surfaces'. Biomedical microdevices, 12 (6):987-1000 [DOI] [Details]
(2010)'Integrated system investigating shear-mediated platelet interactions with von Willebrand factor using microliters of whole blood'
Lincoln B, Ricco AJ, Kent NJ, Basabe-Desmonts L, Lee LP, MacCraith BD, Kenny D, Meade G. (2010) 'Integrated system investigating shear-mediated platelet interactions with von Willebrand factor using microliters of whole blood'. Analytical Biochemistry, 405 (2):174-183 [DOI] [Details]
(2008)'Molecular Basis for Staphylococcus aureus–Mediated Platelet Aggregate Formation Under Arterial Shear In Vitro'
Steven W. Kerrigan, Niamh Clarke, Anthony Loughman, Gerardene Meade, Timothy J. Foster, Dermot Cox (2008) 'Molecular Basis for Staphylococcus aureus–Mediated Platelet Aggregate Formation Under Arterial Shear In Vitro'. Arteriosclerosis Thrombosis and Vascular Biology, 28 (2):335-340 [DOI] [Details]
(2007)'Regulation of bovine brain microvascular endothelial tight junction assembly and barrier function by laminar shear stress'
Colgan OC, Ferguson G, Collins NT, Murphy RP, Meade G, Cahill PA, Cummins PM (2007) 'Regulation of bovine brain microvascular endothelial tight junction assembly and barrier function by laminar shear stress'. American Journal of Physiology - Heart and Circulatory Physiology, 292 :H3190-H3197 [DOI] [Details]
(2007)'Bioinformatic discovery of novel bioactive peptides'
Edwards RJ, Moran N, Devocelle M, Kiernan A, Meade G, Signac W, Foy M, Park SD, Dunne E, Kenny D, Shields DC. (2007) 'Bioinformatic discovery of novel bioactive peptides'. Nature Chemical Biology, 3 (2):108-112 [DOI] [Details]
(2006)'Evidence for a differential functional regulation of the two beta 3-integrins alpha(v)beta(3) and alpha(IIb)beta(3)'
Ahrens, IG;Moran, N;Aylward, K;Meade, G;Moser, M;Assefa, D;Fitzgerald, DJ;Bode, C;Peter, K (2006) 'Evidence for a differential functional regulation of the two beta 3-integrins alpha(v)beta(3) and alpha(IIb)beta(3)'. Experimental Cell Research, 312 :925-937 [DOI] [Details]
(2006)'A novel functional role for the highly conserved alpha-subunit KVGFFKR motif distinct from integrin alphaIIbbeta3 activation processes'
Aylward K, Meade G, Ahrens I, Devocelle M, Moran N. (2006) 'A novel functional role for the highly conserved alpha-subunit KVGFFKR motif distinct from integrin alphaIIbbeta3 activation processes'. Journal of Thrombosis and Haemostasis, 4 (8):1804-1812 [Details]
(2006)'Conformation-specific blockade of the integrin GPIIb/IIIa: a novel antiplatelet strategy that selectively targets activated platelets'
Schwarz M, Meade G, Stoll P, Ylanne J, Bassler N, Chen YC, Hagemeyer CE, Ahrens I, Moran N, Kenny D, Fitzgerald D, Bode C, Peter K. (2006) 'Conformation-specific blockade of the integrin GPIIb/IIIa: a novel antiplatelet strategy that selectively targets activated platelets'. Circulation Research, 99 (1):25-33 [DOI] [Details]
(2006)'Cyclic strain-mediated regulation of vascular endothelial occludin and ZO-1 - Influence on intercellular tight junction assembly and function'
Collins, NT;Cummins, PM;Colgan, OC;Ferguson, G;Birney, YA;Murphy, RP;Meade, G;Cahill, PA (2006) 'Cyclic strain-mediated regulation of vascular endothelial occludin and ZO-1 - Influence on intercellular tight junction assembly and function'. Arteriosclerosis Thrombosis and Vascular Biology, 26 :62-68 [DOI] [Details]
(2005)'A serine-rich glycoprotein of Streptococcus sanguis mediates adhesion to platelets via GPIb'
Plummer C, Wu H, Kerrigan SW, Meade G, Cox D, Ian Douglas CW. (2005) 'A serine-rich glycoprotein of Streptococcus sanguis mediates adhesion to platelets via GPIb'. British Journal of Haematology, 129 (1):101-109 [DOI] [Details]
(2004)'Shear stress modulates the interaction of platelet-secreted matrix proteins with tumor cells through the integrin alpha(v)beta(3)'
Lawler, K;Meade, G;O'Sullivan, G;Kenny, D (2004) 'Shear stress modulates the interaction of platelet-secreted matrix proteins with tumor cells through the integrin alpha(v)beta(3)'. American Journal of Physiology - Cell Physiology, 287 :1320-1327 [DOI] [Details]
(2003)'A palmitylated peptide derived from the glycoprotein Ibb cytoplasmic tail inhibits platelet activation'
Martin K., Meade G., Moran N., Shields D.C., Kenny D. (2003) 'A palmitylated peptide derived from the glycoprotein Ibb cytoplasmic tail inhibits platelet activation'. Journal of Thrombosis and Haemostasis, 1 (1212):2643-2652   [Details]
(2001)'Structure, function and evolution of glutathione transferases: implications for classification of non-mammalian members of an ancient enzyme superfamily'
Sheehan D, Meade G, Foley VM, Dowd CA; (2001) 'Structure, function and evolution of glutathione transferases: implications for classification of non-mammalian members of an ancient enzyme superfamily'. The Biochemical Journal, 360 (Pt 1):1-16 [Details]
(2000)'Chemical modulation of chemotherapy resistance in cultured oesophageal carcinoma cells'
Sheehan, D; Meade, G; (2000) 'Chemical modulation of chemotherapy resistance in cultured oesophageal carcinoma cells'. Biochemical Society Transactions, 28 (*):27-32 [Details]
(2000)'Chemical modulation of chemotherapy resistance in cultured oesophageal carcinoma cells'
Sheehan D, Meade G; (2000) 'Chemical modulation of chemotherapy resistance in cultured oesophageal carcinoma cells'. Biochemical Society Transactions, 28 (2):27-32 [Details]

Conference Publications

 YearPublication
(2011)Oral Communication XXIII Congress of The International Society of Thrombosis & Haemostasis
Meade GR, O'Brien S, Somers M, Plukett G, McAtamney C, Ricco AJ, Kenny D. (2011) Platelet behaviour on von Willebrand Factor under arterial fluid shear differs between healthy individuals and patients with cardiovascular disease on dual anti-platelet therapy Oral Communication XXIII Congress of The International Society of Thrombosis & Haemostasis [Details]
(2000)BIOCHEMICAL SOCIETY TRANSACTIONS
Sheehan, D;Meade, G (2000) Chemical modulation of chemotherapy resistance in cultured oesophageal carcinoma cells BIOCHEMICAL SOCIETY TRANSACTIONS , pp.27-32 [Details]

Abstract

 YearPublication
(2002)The platelet secreteome potentiates the invasiveness of metastatic cells at venous shear rates: An effect that is inhibited by aspirin.
Lawler, K,Meade, G,O'Sullivan, G,Kenny, D (2002) The platelet secreteome potentiates the invasiveness of metastatic cells at venous shear rates: An effect that is inhibited by aspirin. Abstract [Details]

Book Reviews

 YearPublication
(2001)Structure, function and evolution of glutathione transferases: implications for classification of non-mammalian members of an ancient enzyme superfamily.
Sheehan, D,Meade, G,Foley, VM,Dowd, CA (2001) Structure, function and evolution of glutathione transferases: implications for classification of non-mammalian members of an ancient enzyme superfamily. Book Reviews [Details]

Professional Activities

Professional Associations

 AssociationFunctionFrom / To
Irish Association of Pharmacologists Member20-JUN-17 /
The North Amercian Vascular Biology Organization Member02-JAN-08 / 31-DEC-10
Cancer Trials Ireland (Formerly ICORG) Member02-JAN-14 / 31-DEC-15
The Irish Society for Gene & Cell Therapeutics Member02-JAN-08 / 31-DEC-10
The International Society of Thorombosis & Haemostasis Member02-JAN-03 / 31-DEC-14

Committees

 CommitteeFunctionFrom / To
Undergraduate Committee BSc Paramedic Studies Member2017 / 2020
MRes/PhD Student Programme - Royal College of Surgeons in Ireland Reviewer2005 / 2012

Employment

 EmployerPositionFrom / To
Biochemistry Department and National Food & Biotechnology Centre (NFBC), UCC Research Assistant (Part-Time)02-JAN-96 / 31-MAY-97
Royal College of Surgeons in Ireland Post-Doctoral Researcher02-JAN-00 / 31-DEC-04
University College Cork Research Assistant (Internship)02-JAN-99 / 31-DEC-00
University College Cork Lecturer27-FEB-17 /
Royal College of Surgeons in Ireland Manager - Imaging Microscopy31-DEC-04 / 31-DEC-05
Royal College of Surgeons in Ireland Senior Research Scientist and Scheduled Lecturer31-DEC-05 / 31-DEC-12
Royal College of Surgeons in Ireland Senior Research Scientist and Scheduled Lecturer31-DEC-05 / 31-DEC-12
Cancer Trials Ireland Clinical Research Associate (Trainee)30-SEP-14 / 31-AUG-15
Dublin City University Senior Research Scientist and Scheduled Lecturer31-MAR-12 / 31-MAR-14
Buckeye Technologies Ireland QC Analyst (Part-Time)02-JAN-98 / 31-DEC-98

Journal Activities

 JournalRoleTo / From
Thrombosis And Haemostasis Referee-

Other Activities

 Description

External Reviewer: MSc-PhD Transfer Waterford Institute of Technology

Contact details

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School of Biological, Earth and Environmental Sciences

An Scoil Eolaíochtaí Bitheolaíocha, Domhaneolaíocha agus Comhshaoil

University College Cork, Distillery Fields, North Mall, Cork, Ireland T23 N73K

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