Research Profile

Jane English

Biography

Jane received her PhD in Molecular Psychiatry and Proteomics from the Royal College of Surgeons in Ireland (RCSI) in 2008. Jane subsequently joined the M.J. Dunn laboratory as a post-doctoral researcher at the University College Dublin (UCD) Conway Institute, where she developed proteomic methods to study biologically relevant sub-proteomes in post-mortem brain from patients with Schizophrenia. In 2013, Jane took on the role of Programme Manager for a HRB funded Biomarker Discovery Programme in Psychosis in the DR Cotter laboratory, RCSI. In this capacity, her research focused on using mass spectrometry based -discovery and -targeted workflows to identify and verify blood-based protein biomarkers which predict the onset of psychotic disorder in children with “at risk mental state”. In 2017, Jane was awarded a Science Foundation Ireland - Industry Fellowship to gain industry experience in personalised diagnostics and the development of commercial biomarker assays at Inform Bioscience Ltd., Co. Cork; http://www.informbio.com/. In 2017, Jane was awarded a prestigious Health Research Board -Emerging Investigator Award and is the Principal Investigator of a Biomarker Discovery Programme in Autism Spectrum Disorder, at INFANT http://www.infantcentre.ie/. In 2018, Jane was appointed Lecturer in the Department of Anatomy and Neuroscience, UCC; https://www.ucc.ie/en/anatomy/. For full publication metrics visit google scholar https://scholar.google.com/citations?user=h7x0IQoAAAAJ&hl=en.

Research Interests

Dr English’s research focuses on the application of proteomics, bioinformatics, and systems biology approaches to study molecular pathways implicated in human health and disease, with a focus on neurodevelopmental and neuropsychiatric disorders.

Research Grants

 ProjectFunding
Body
Start DateEnd DateAward
Biomarker Discovery in Ultra High Risk for Psychosis: towards prediction of psychotic disorder, non-psychotic mental disorders and recovery.Health Research Board01-FEB-18€370,000.00
BIOMARKER VERIFICATION AND VALIDATION FOR PREECLAMPSIAScience Foundation Ireland01-MAY-1701-MAR-18€53,831.00
Iron regulation in the brain and its relationship to myelin pathology in schizophreniaHealth Research Board01-OCT-10€285,000.00
“Biomarker Discovery and Validation in Autism Spectrum DisorderHealth Research Board01-APR-1801-APR-22€800,000.00

Publications

Peer Reviewed Journals

 YearPublication
(2018)'Blood-Based Protein Changes in Childhood Are Associated With Increased Risk for Later Psychotic Disorder: Evidence From a Nested Case-Control Study of the ALSPAC Longitudinal Birth Cohort'
English JA;Lopez LM;O'Gorman A;Föcking M;Hryniewiecka M;Scaife C;Sabherwal S;Wynne K;Dicker P;Rutten BPF;Lewis G;Zammit S;Cannon M;Cagney G;Cotter DR; (2018) 'Blood-Based Protein Changes in Childhood Are Associated With Increased Risk for Later Psychotic Disorder: Evidence From a Nested Case-Control Study of the ALSPAC Longitudinal Birth Cohort'. Schizophrenia bulletin, 44 (2) [DOI] [Details]
(2016)'Dataset of mouse hippocampus profiled by LC-MS/MS for label-free quantitation'
English JA;Scaife C;Harauma A;Focking M;Wynne K;Cagney G;Moriguchi T;Cotter DR; (2016) 'Dataset of mouse hippocampus profiled by LC-MS/MS for label-free quantitation'. Data In Brief, 7 [DOI] [Details]
(2016)'Dysregulation of miRNA-9 in a Subset of Schizophrenia Patient-Derived Neural Progenitor Cells'
Topol A;Zhu S;Hartley BJ;English J;Hauberg ME;Tran N;Rittenhouse CA;Simone A;Ruderfer DM;Johnson J;Readhead B;Hadas Y;Gochman PA;Wang YC;Shah H;Cagney G;Rapoport J;Gage FH;Dudley JT;Sklar P;Mattheisen M;Cotter D;Fang G;Brennand KJ; (2016) 'Dysregulation of miRNA-9 in a Subset of Schizophrenia Patient-Derived Neural Progenitor Cells'. Cell Reports, 15 (5) [DOI] [Details]
(2016)'Blood biomarker discovery in drug-free schizophrenia: the contributionof proteomics and multiplex immunoassays'
Sabherwal S;English JA;Föcking M;Cagney G;Cotter DR; (2016) 'Blood biomarker discovery in drug-free schizophrenia: the contributionof proteomics and multiplex immunoassays'. Expert Review Of Proteomics, 13 (12) [DOI] [Details]
(2015)'Proteomic and genomic evidence implicates the postsynaptic density in schizophrenia'
Föcking M;Lopez LM;English JA;Dicker P;Wolff A;Brindley E;Wynne K;Cagney G;Cotter DR; (2015) 'Proteomic and genomic evidence implicates the postsynaptic density in schizophrenia'. Molecular Psychiatry, 20 (4) [DOI] [Details]
(2015)'Increased abundance of translation machinery in stem cell-derived neural progenitor cells from four schizophrenia patients'
Topol A;English JA;Flaherty E;Rajarajan P;Hartley BJ;Gupta S;Desland F;Zhu S;Goff T;Friedman L;Rapoport J;Felsenfeld D;Cagney G;Mackay-Sim A;Savas JN;Aronow B;Fang G;Zhang B;Cotter D;Brennand KJ; (2015) 'Increased abundance of translation machinery in stem cell-derived neural progenitor cells from four schizophrenia patients'. Translational Psychiatry, 5 [DOI] [Details]
(2015)'Maternal immune activation induces changes in myelin and metabolic proteins, some of which can be prevented with risperidone in adolescence'
Farrelly L;Föcking M;Piontkewitz Y;Dicker P;English J;Wynne K;Cannon M;Cagney G;Cotter DR; (2015) 'Maternal immune activation induces changes in myelin and metabolic proteins, some of which can be prevented with risperidone in adolescence'. Developmental Neuroscience, 37 (1) [DOI] [Details]
(2015)'Reduced protein synthesis in schizophrenia patient-derived olfactory cells'
English JA;Fan Y;Föcking M;Lopez LM;Hryniewiecka M;Wynne K;Dicker P;Matigian N;Cagney G;Mackay-Sim A;Cotter DR; (2015) 'Reduced protein synthesis in schizophrenia patient-derived olfactory cells'. Translational Psychiatry, 5 [DOI] [Details]
(2014)'Targeted proteomics for validation of biomarkers in early psychosis'
English JA;Wynne K;Cagney G;Cotter DR; (2014) 'Targeted proteomics for validation of biomarkers in early psychosis'. Biological Psychiatry, 76 (6) [DOI] [Details]
(2014)'Adolescent Risperidone treatment alters protein expression associated with protein trafficking and cellular metabolism in the adult rat prefrontal cortex'
Farrelly LA;Dicker P;Wynne K;English J;Cagney G;Föcking M;Cotter DR; (2014) 'Adolescent Risperidone treatment alters protein expression associated with protein trafficking and cellular metabolism in the adult rat prefrontal cortex'. Journal of Proteomics, 14 (12) [DOI] [Details]
(2013)'Omega-3 fatty acid deficiency disrupts endocytosis, neuritogenesis, and mitochondrial protein pathways in the mouse hippocampus'
English JA;Harauma A;Föcking M;Wynne K;Scaife C;Cagney G;Moriguchi T;Cotter DR; (2013) 'Omega-3 fatty acid deficiency disrupts endocytosis, neuritogenesis, and mitochondrial protein pathways in the mouse hippocampus'. Frontiers In Genetics, 4 [DOI] [Details]
(2012)'Partitioning the proteome: phase separation for targeted analysis of membrane proteins in human post-mortem brain'
English JA;Manadas B;Scaife C;Cotter DR;Dunn MJ; (2012) 'Partitioning the proteome: phase separation for targeted analysis of membrane proteins in human post-mortem brain'. Plos One, 7 (6) [DOI] [Details]
(2011)'The neuroproteomics of schizophrenia'
English JA;Pennington K;Dunn MJ;Cotter DR; (2011) 'The neuroproteomics of schizophrenia'. Biological Psychiatry, 69 (2) [DOI] [Details]
(2011)'Common proteomic changes in the hippocampus in schizophrenia and bipolar disorder and particular evidence for involvement of cornu ammonis regions 2 and 3'
Föcking M;Dicker P;English JA;Schubert KO;Dunn MJ;Cotter DR; (2011) 'Common proteomic changes in the hippocampus in schizophrenia and bipolar disorder and particular evidence for involvement of cornu ammonis regions 2 and 3'. Archives of General Psychiatry, 68 (5) [DOI] [Details]
(2010)'Image analysis tools and emerging algorithms for expression proteomics'
Dowsey AW;English JA;Lisacek F;Morris JS;Yang GZ;Dunn MJ; (2010) 'Image analysis tools and emerging algorithms for expression proteomics'. Journal of Proteomics, 10 (23) [DOI] [Details]
(2010)'Peptide fractionation in proteomics approaches'
Manadas B;Mendes VM;English J;Dunn MJ; (2010) 'Peptide fractionation in proteomics approaches'. Expert Review Of Proteomics, 7 (5) [DOI] [Details]
(2009)'Assessing the use of thermal treatment to preserve the intact proteomes of post-mortem heart and brain tissue'
Robinson AA;Westbrook JA;English JA;Borén M;Dunn MJ; (2009) 'Assessing the use of thermal treatment to preserve the intact proteomes of post-mortem heart and brain tissue'. Journal of Proteomics, 9 (19) [DOI] [Details]
(2009)'Comparative analysis of OFFGel, strong cation exchange with pH gradient, and RP at high pH for first-dimensional separation of peptides from a membrane-enriched protein fraction'
Manadas B;English JA;Wynne KJ;Cotter DR;Dunn MJ; (2009) 'Comparative analysis of OFFGel, strong cation exchange with pH gradient, and RP at high pH for first-dimensional separation of peptides from a membrane-enriched protein fraction'. Journal of Proteomics, 9 (22) [DOI] [Details]
(2009)'2-D DIGE analysis implicates cytoskeletal abnormalities in psychiatric disease'
English JA;Dicker P;Föcking M;Dunn MJ;Cotter DR; (2009) '2-D DIGE analysis implicates cytoskeletal abnormalities in psychiatric disease'. Journal of Proteomics, 9 (12) [DOI] [Details]
(2008)'Prominent synaptic and metabolic abnormalities revealed by proteomic analysis of the dorsolateral prefrontal cortex in schizophrenia and bipolar disorder'
Pennington K;Beasley CL;Dicker P;Fagan A;English J;Pariante CM;Wait R;Dunn MJ;Cotter DR; (2008) 'Prominent synaptic and metabolic abnormalities revealed by proteomic analysis of the dorsolateral prefrontal cortex in schizophrenia and bipolar disorder'. Molecular Psychiatry, 13 (12) [DOI] [Details]
(2006)'Examination of 2-DE in the Human Proteome Organisation Brain Proteome Project pilot studies with the new RAIN gel matching technique'
Dowsey AW;English J;Pennington K;Cotter D;Stuehler K;Marcus K;Meyer HE;Dunn MJ;Yang GZ; (2006) 'Examination of 2-DE in the Human Proteome Organisation Brain Proteome Project pilot studies with the new RAIN gel matching technique'. Journal of Proteomics, 6 (18) [DOI] [Details]

Conference Publications

 YearPublication
(2009)5th BSPR-EBI meeting, proteomics: from Technology to New Biology 8-10 July 2008, Wellcome Trust Conference Centre, Hinxton, Cambridge, UK
English JA;Polden J;Robinson AA; (2009) Report 5th BSPR-EBI meeting, proteomics: from Technology to New Biology 8-10 July 2008, Wellcome Trust Conference Centre, Hinxton, Cambridge, UK [DOI] [Details]
(2008)1st Irish proteomics workshop April 17th 2008, University College Dublin, Conway Institute, Dublin, Ireland
McManus CA;English JA; (2008) Report 1st Irish proteomics workshop April 17th 2008, University College Dublin, Conway Institute, Dublin, Ireland [DOI] [Details]

Contact details

  • Jane English
    Lecturer
  • jane.english@ucc.ie
  • Western Gateway Building
    Western Rd,
    University College Cork
    Ireland

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