Research Profile

Jianghuai Wang

Biography

Research Interests

Despite significant advances in our understanding of the molecular and genetic basis of sepsis and its associated immunologic response, sepsis remains a problem worldwide population.  The defining features of severe sepsis remain multi-organ dysfunctions, which leads, almost inexorably, to significant morbidity and often mortality.  Mortality rates associated with severe sepsis remain as high as 30%.  These stark facts have prompted an ongoing search for novel mediators of lethality in sepsis, as well as the identification of therapeutic modalities aimed at targeting such mediators.

The mammalian Toll-like receptor (TLR) family plays a pivotal role in host defence against bacterial infection by recognising invading microbial pathogens and initiating an inflammatory response.  However, dysregulated TLR activation with excessive release of proinflammatory cytokines may lead to the development of septic shock syndrome.  Host innate immunity against microbial infection also depends on bacterial phagocytosis and phagosome maturation after ingestion of the invading bacteria by specialised phagocytes such as macrophages.  Defects in phagocyte-mediated antimicrobial activity may result in susceptibility to microbial infection, 

 



My main research interests include: a) regulation and modulation of host innate immune response and intracellular signal transduction pathways during surgical infection and sepsis; b) cellular reprogramming: a new balance between proinflammatory response and phagocyte-mediated antimicrobial activity.  The aim of my research is to unravel the mechanisms underlying the development of microbial sepsis and to identify novel strategies for treatment of bacterial infection and sepsis in the clinic.

Publications

Peer Reviewed Journals

 YearPublication
(2013)'Less stress, more success? Oncological implications of surgery-induced oxidative stress'
O'Leary, DP,Wang, JH,Cotter, TG,Redmond, HP (2013) 'Less stress, more success? Oncological implications of surgery-induced oxidative stress'. Gut, 62 :461-470 [DOI] [Details]
(2013)'Silencing of TLR4 Increases Tumor Progression and Lung Metastasis in a Murine Model of Breast Cancer'
Ahmed, A,Wang, JH,Redmond, HP (2013) 'Silencing of TLR4 Increases Tumor Progression and Lung Metastasis in a Murine Model of Breast Cancer'. Annals of Surgical Oncology, 20 :389-396 [DOI] [Details]
(2013)'Less stress, more success? Oncological implications of surgery-induced oxidative stress'
O'Leary DP, Wang JH, Cotter TG, Redmond HP (2013) 'Less stress, more success? Oncological implications of surgery-induced oxidative stress'. Gut, 62 (3):461-470 [DOI] [Details]
(2013)'MicroRNA-146a Is Upregulated by and Negatively Regulates TLR2 Signaling'
Quinn, EM,Wang, JH,O'Callaghan, G,Redmond, HP (2013) 'MicroRNA-146a Is Upregulated by and Negatively Regulates TLR2 Signaling'. Plos One, 8 [DOI] [Details]
(2013)'Laparotomy and laparoscopy diversely affect macrophage-associated antimicrobial activity in a murine model'
Huang, SG,Li, YP,Zhang, Q,Redmond, HP,Wang, JH,Wang, J (2013) 'Laparotomy and laparoscopy diversely affect macrophage-associated antimicrobial activity in a murine model'. Bmc Immunology, 14 [DOI] [Details]
(2013)'Inefficient antimicrobial functions of innate phagocytes render infant mice more susceptible to bacterial infection'
Zhang, Q,Coveney, AP,Yu, SL,Liu, JH,Li, YP,Blankson, S,Redmond, HP,Wang, JH,Wang, J (2013) 'Inefficient antimicrobial functions of innate phagocytes render infant mice more susceptible to bacterial infection'. Eur J Immunol, 43 :1322-1332 [DOI] [Details]
(2012)'TLR-4 Signalling Accelerates Colon Cancer Cell Adhesion via NF-kappa B Mediated Transcriptional Up-Regulation of Nox-1'
O'Leary, DP,Bhatt, L,Woolley, JF,Gough, DR,Wang, JH,Cotter, TG,Redmond, HP (2012) 'TLR-4 Signalling Accelerates Colon Cancer Cell Adhesion via NF-kappa B Mediated Transcriptional Up-Regulation of Nox-1'. Plos One, 7 [DOI] [Details]
(2012)'TLR-4 signalling accelerates colon cancer cell adhesion via NF-κB mediated transcriptional up-regulation of Nox-1'
O'Leary DP, Bhatt L, Woolley JF, Gough DR, Wang JH, Cotter TG, Redmond HP (2012) 'TLR-4 signalling accelerates colon cancer cell adhesion via NF-κB mediated transcriptional up-regulation of Nox-1'. Plos One, 7 (10) [DOI] [Details]
(2010)'Surgical injury enhances the expression of genes that mediate breast cancer metastasis to the lung'
Al-Sahaf O, Wang JH, Browne TJ, Cotter TG, Redmond HP; (2010) 'Surgical injury enhances the expression of genes that mediate breast cancer metastasis to the lung'. Annals of Surgery, 252 (6):1037-1043 [DOI] [Details]
(2010)'The Evolving Role of Taurolidine in Cancer Therapy'
Neary, PM; Hallihan, P; Wang, JH; Pfirrmann, RW; Bouchier-Hayes, DJ; Redmond, HP; (2010) 'The Evolving Role of Taurolidine in Cancer Therapy'. Annals of Surgery, 17 :1135-1143 [DOI] [Details]
(2010)'Hypoxia increases the metastatic ability of breast cancer cells via upregulation of CXCR4'
Cronin, PA; Wang, JH; Redmond, HP; (2010) 'Hypoxia increases the metastatic ability of breast cancer cells via upregulation of CXCR4'. BMC Cancer, 10 [DOI] [Details]
(2010)'ST2 Negatively Regulates TLR2 Signaling, but Is Not Required for Bacterial Lipoprotein-Induced Tolerance'
Liu, JH; Buckley, JM; Redmond, HP; Wang, JH; (2010) 'ST2 Negatively Regulates TLR2 Signaling, but Is Not Required for Bacterial Lipoprotein-Induced Tolerance'. Journal of Immunology, 184 :5802-5808 [DOI] [Details]
(2010)'Inhibition of Nuclear Factor-kappa B and p38 Mitogen-Activated Protein Kinase Does Not Always Have Adverse Effects on Wound Healing'
O'Sullivan, A; O'Malley, D; Coffey, J; Wang, JH; Redmond, H; (2010) 'Inhibition of Nuclear Factor-kappa B and p38 Mitogen-Activated Protein Kinase Does Not Always Have Adverse Effects on Wound Healing'. Surgical Infections, 11 :7-11 [DOI] [Details]
(2009)'NF-KB and P38 MAPK Inhibition Improve Survival in Endotoxin Shock and in a Cecal Ligation and Puncture Model of Sepsis in Combination With Antibiotic Therapy'
O'Sullivan, AW,Wang, JH,Redmond, HP (2009) 'NF-KB and P38 MAPK Inhibition Improve Survival in Endotoxin Shock and in a Cecal Ligation and Puncture Model of Sepsis in Combination With Antibiotic Therapy'. Journal of Surgical Research, 152 :46-53 [DOI] [Details]
(2009)'Advanced glycation end products and lipopolysaccharide synergistically stimulate proinflammatory cytokine/chemokine production in endothelial cells via activation of both mitogen-activated protein kinases and nuclear factor-kappa B'
Liu, JH,Zhao, SC,Tang, J,Li, ZJ,Zhong, TY,Liu, YW,Chen, DY,Zhao, MZ,Li, YS,Gong, XW,Deng, P,Wang, JH,Jiang, Y; (2009) 'Advanced glycation end products and lipopolysaccharide synergistically stimulate proinflammatory cytokine/chemokine production in endothelial cells via activation of both mitogen-activated protein kinases and nuclear factor-kappa B'. Febs Journal, 276 :4598-4606 [DOI] [Details]
(2009)'Bacterial endotoxin enhances colorectal cancer cell adhesion and invasion through TLR-4 and NF-kappa B-dependent activation of the urokinase plasminogen activator system'
Killeen, SD,Wang, JH,Andrews, EJ,Redmond, HP; (2009) 'Bacterial endotoxin enhances colorectal cancer cell adhesion and invasion through TLR-4 and NF-kappa B-dependent activation of the urokinase plasminogen activator system'. British Journal of Cancer, 100 :1589-1602 [DOI] [Details]
(2009)'Combined Ifn-Gamma-Endostatin Gene Therapy and Radiotherapy Attenuates Primary Breast Tumor Growth and Lung Metastases Via Enhanced Ctl and Nk Cell Activation and Attenuated Tumor Angiogenesis In A Murine Model'
Liu, LL, Smith, MJ, Sun, BS, Wang, GJ, Redmond, HP, Wang, JH; (2009) 'Combined Ifn-Gamma-Endostatin Gene Therapy and Radiotherapy Attenuates Primary Breast Tumor Growth and Lung Metastases Via Enhanced Ctl and Nk Cell Activation and Attenuated Tumor Angiogenesis In A Murine Model'. Annals of Surgical Oncology, 16 (5):1403-1411 [DOI] [Details]
(2009)'Combined IFN-gamma-Endostatin Gene Therapy and Radiotherapy Attenuates Primary Breast Tumor Growth and Lung Metastases via Enhanced CTL and NK Cell Activation and Attenuated Tumor Angiogenesis in a Murine Model'
Liu, LL,Smith, MJ,Sun, BS,Wang, GJ,Redmond, HP,Wang, JH; (2009) 'Combined IFN-gamma-Endostatin Gene Therapy and Radiotherapy Attenuates Primary Breast Tumor Growth and Lung Metastases via Enhanced CTL and NK Cell Activation and Attenuated Tumor Angiogenesis in a Murine Model'. Annals of Surgery, 16 :1403-1411 [DOI] [Details]
(2009)'Advanced Glycation End Products and Lipopolysaccharide Synergistically Stimulate Proinflammatory Cytokine/Chemokine Production In Endothelial Cells Via Activation of Both Mitogen-Activated Protein Kinases and Nuclear Factor-Kappa B'
Liu, JH, Zhao, SC, Tang, J, Li, ZJ, Zhong, TY, Liu, YW, Chen, DY, Zhao, MZ, Li, YS, Gong, XW, Deng, P, Wang, JH, Jiang, Y; (2009) 'Advanced Glycation End Products and Lipopolysaccharide Synergistically Stimulate Proinflammatory Cytokine/Chemokine Production In Endothelial Cells Via Activation of Both Mitogen-Activated Protein Kinases and Nuclear Factor-Kappa B'. Febs Journal, 276 (16):4598-4606 [DOI] [Details]
(2009)'Analysis of differential gene expression in colorectal cancer and stroma using fluorescence-activated cell sorting purification'
Smith, MJ,Culhane, AC,Donovan, M,Coffey, JC,Barry, BD,Kelly, MA,Higgins, DG,Wang, JH,Kirwan, WO,Cotter, TG,Redmond, HP; (2009) 'Analysis of differential gene expression in colorectal cancer and stroma using fluorescence-activated cell sorting purification'. British Journal of Cancer, 100 :1452-1464 [DOI] [Details]
(2009)'Bacterial Endotoxin Enhances Colorectal Cancer Cell Adhesion and Invasion Through Tlr-4 and Nf-Kappa B-Dependent Activation of The Urokinase Plasminogen Activator System'
Killeen, SD, Wang, JH, Andrews, EJ, Redmond, HP; (2009) 'Bacterial Endotoxin Enhances Colorectal Cancer Cell Adhesion and Invasion Through Tlr-4 and Nf-Kappa B-Dependent Activation of The Urokinase Plasminogen Activator System'. British Journal of Cancer, 100 (10):1589-1602 [DOI] [Details]
(2009)'Analysis of Differential Gene Expression In Colorectal Cancer and Stroma Using Fluorescence-Activated Cell Sorting Purification'
Smith, MJ, Culhane, AC, Donovan, M, Coffey, JC, Barry, BD, Kelly, MA, Higgins, DG, Wang, JH, Kirwan, WO, Cotter, TG, Redmond, HP; (2009) 'Analysis of Differential Gene Expression In Colorectal Cancer and Stroma Using Fluorescence-Activated Cell Sorting Purification'. British Journal of Cancer, 100 (9):1452-1464 [DOI] [Details]
(2008)'Mechanisms Driving Local Breast Cancer Recurrence In A Model of Breast-Conserving Surgery'
Smith, MJ, Culhane, AC, Killeen, S, Kelly, MA, Wang, JH, Cotter, TG, Redmond, HP; (2008) 'Mechanisms Driving Local Breast Cancer Recurrence In A Model of Breast-Conserving Surgery'. Annals of Surgical Oncology, 15 (10):2954-2964 [DOI] [Details]
(2008)'Statin (Cerivastatin) Protects Mice Against Sepsis-Related Death via Reduced Proinflammatory Cytokines and Enhanced Bacterial Clearance'
Chaudhry, MZ,Wang, JH,Blankson, S,Redmond, HP; (2008) 'Statin (Cerivastatin) Protects Mice Against Sepsis-Related Death via Reduced Proinflammatory Cytokines and Enhanced Bacterial Clearance'. Surgical Infections, 9 :183-194 [DOI] [Details]
(2008)'Mechanisms driving local breast cancer recurrence in a model of breast-conserving surgery'
Smith, MJ,Culhane, AC,Killeen, S,Kelly, MA,Wang, JH,Cotter, TG,Redmond, HP; (2008) 'Mechanisms driving local breast cancer recurrence in a model of breast-conserving surgery'. Annals of Surgery, 15 :2954-2964 [DOI] [Details]
(2007)'Taurolidine Induces Apoptosis of Murine Melanoma Cells In Vitro and In Vivo By Modulation of The Bcl-2 Family Proteins'
Sun, BS, Wang, JH, Liu, LL, Gong, SH, Redmond, HP; (2007) 'Taurolidine Induces Apoptosis of Murine Melanoma Cells In Vitro and In Vivo By Modulation of The Bcl-2 Family Proteins'. Journal of Surgical Oncology, 96 (3):241-248 [DOI] [Details]
(2007)'Characterization of the effects of cyclooxygenase-2 inhibition in the regulation of apoptosis in human small and non-small cell lung cancer cell lines'
Alam, M,Wang, JH,Coffey, JC,Qadri, SS,O'Donnell, A,Aherne, T,Redmond, HP; (2007) 'Characterization of the effects of cyclooxygenase-2 inhibition in the regulation of apoptosis in human small and non-small cell lung cancer cell lines'. Annals of Surgery, 14 :2678-2684 [DOI] [Details]
(2007)'Inhibition of urokinase plasminogen activator with a novel enzyme inhibitor, wxc-340, ameliorates endotoxin and surgery-accelerated growth of murine metastases'
Killeen, SD,Andrews, EJ,Wang, JH,Wu, T,Schmalix, W,Muehlenweg, B,Redmond, HP; (2007) 'Inhibition of urokinase plasminogen activator with a novel enzyme inhibitor, wxc-340, ameliorates endotoxin and surgery-accelerated growth of murine metastases'. British Journal of Cancer, 96 :262-268 [DOI] [Details]
(2007)'Laparoscopic surgery protects against the oncologic adverse effects of open surgery by attenuating endothelial progenitor cell mobilization'
Condon, ET,Barry, BD,Wang, JH,Kirwan, WO,Redmond, HP; (2007) 'Laparoscopic surgery protects against the oncologic adverse effects of open surgery by attenuating endothelial progenitor cell mobilization'. Surgical Endoscopy and Other Interventional Techniques, 21 :87-90 [DOI] [Details]
(2007)'Enteric bacteria and their antigens may stimulate postoperative peritoneal adhesion formation'
Cahill, RA,Wang, JH,Redmond, HP; (2007) 'Enteric bacteria and their antigens may stimulate postoperative peritoneal adhesion formation'. Journal of Surgery, 141 :403-410 [DOI] [Details]
(2007)'Taurolidine induces apoptosis of murine melanoma cells in vitro and in vivo by modulation of the Bcl-2 family proteins'
Sun, BS,Wang, JH,Liu, LL,Gong, SH,Redmond, HP; (2007) 'Taurolidine induces apoptosis of murine melanoma cells in vitro and in vivo by modulation of the Bcl-2 family proteins'. Journal of Surgical Oncology, 96 :241-248 [DOI] [Details]
(2007)'Tolerization with BLP down-regulates HMGB1 - a critical mediator of sepsis-related lethality'
Coffey, JC,Wang, JH,Kelly, R,Romics, L,O'Callaghan, A,Fiuza, C,Redmond, HP; (2007) 'Tolerization with BLP down-regulates HMGB1 - a critical mediator of sepsis-related lethality'. Journal of Leukocyte Biology, 82 :906-914 [DOI] [Details]
(2007)'Laparoscopic Surgery Protects Against The Oncologic Adverse Effects of Open Surgery By Attenuating Endothelial Progenitor Cell Mobilization'
Condon, ET, Barry, BD, Wang, JH, Kirwan, WO, Redmond, HP; (2007) 'Laparoscopic Surgery Protects Against The Oncologic Adverse Effects of Open Surgery By Attenuating Endothelial Progenitor Cell Mobilization'. Surgical Endoscopy and Other Interventional Techniques, 21 (1):87-90 [DOI] [Details]
(2007)'Enteric Bacteria and Their Antigens May Stimulate Postoperative Peritoneal Adhesion Formation'
Cahill, RA, Wang, JH, Redmond, HP; (2007) 'Enteric Bacteria and Their Antigens May Stimulate Postoperative Peritoneal Adhesion Formation'. Journal of Surgery, 141 (3):403-410 [DOI] [Details]
(2007)'Inhibition of Urokinase Plasminogen Activator With A Novel Enzyme Inhibitor, Wxc-340, Ameliorates Endotoxin and Surgery-Accelerated Growth of Murine Metastases'
Killeen, SD, Andrews, EJ, Wang, JH, Wu, T, Schmalix, W, Muehlenweg, B, Redmond, HP; (2007) 'Inhibition of Urokinase Plasminogen Activator With A Novel Enzyme Inhibitor, Wxc-340, Ameliorates Endotoxin and Surgery-Accelerated Growth of Murine Metastases'. British Journal of Cancer, 96 (2):262-268 [DOI] [Details]
(2007)'Tolerization With Blp Down-Regulates Hmgb1 - A Critical Mediator of Sepsis-Related Lethality'
Coffey, JC, Wang, JH, Kelly, R, Romics, L, O'Callaghan, A, Fiuza, C, Redmond, HP; (2007) 'Tolerization With Blp Down-Regulates Hmgb1 - A Critical Mediator of Sepsis-Related Lethality'. Journal of Leukocyte Biology, 82 (4):906-914 [DOI] [Details]
(2007)'Characterization of The Effects of Cyclooxygenase-2 Inhibition In The Regulation of Apoptosis In Human Small and Non-Small Cell Lung Cancer Cell Lines'
Alam, M, Wang, JH, Coffey, JC, Qadri, SS, O'Donnell, A, Aherne, T, Redmond, HP; (2007) 'Characterization of The Effects of Cyclooxygenase-2 Inhibition In The Regulation of Apoptosis In Human Small and Non-Small Cell Lung Cancer Cell Lines'. Annals of Surgical Oncology, 14 (9):2678-2684 [DOI] [Details]
(2006)'Hypertonic saline attenuates colonic tumor cell metastatic potential by activating transmembrane sodium conductance'
Shields, CJ,Winter, DC,Geibel, JP,O'Sullivan, GC,Wang, JH,Redmond, HP; (2006) 'Hypertonic saline attenuates colonic tumor cell metastatic potential by activating transmembrane sodium conductance'. Journal of Membrane Biology, 211 :35-42 [DOI] [Details]
(2006)'The targeting of phosphoinositide-3 kinase attenuates pulmonary metastatic tumor growth following laparotomy'
Coffey, JC,Wang, JH,Bouchier-Hayes, D,Cotter, TG,Redmond, HP; (2006) 'The targeting of phosphoinositide-3 kinase attenuates pulmonary metastatic tumor growth following laparotomy'. Annals of Surgery, 243 :250-256 [DOI] [Details]
(2006)'Bacterial lipoprotein-induced self-tolerance and cross-tolerance to LPS are associated with reduced IRAK-1 expression and MyD88-IRAK complex formation'
Li, CH,Wang, JH,Redmond, HP; (2006) 'Bacterial lipoprotein-induced self-tolerance and cross-tolerance to LPS are associated with reduced IRAK-1 expression and MyD88-IRAK complex formation'. Journal of Leukocyte Biology, 79 :867-875 [DOI] [Details]
(2006)'Bacterial Lipoprotein-Induced Self-Tolerance and Cross-Tolerance to Lps Are Associated With Reduced Irak-1 Expression and Myd88-Irak Complex Formation'
Li, CH, Wang, JH, Redmond, HP; (2006) 'Bacterial Lipoprotein-Induced Self-Tolerance and Cross-Tolerance to Lps Are Associated With Reduced Irak-1 Expression and Myd88-Irak Complex Formation'. Journal of Leukocyte Biology, 79 (4):867-875 [DOI] [Details]
(2006)'Hypertonic Saline Attenuates Colonic Tumor Cell Metastatic Potential By Activating Transmembrane Sodium Conductance'
Shields, CJ, Winter, DC, Geibel, JP, O'Sullivan, GC, Wang, JH, Redmond, HP; (2006) 'Hypertonic Saline Attenuates Colonic Tumor Cell Metastatic Potential By Activating Transmembrane Sodium Conductance'. Journal of Membrane Biology, 211 (1):35-42 [DOI] [Details]
(2005)'Activated protein C attenuates acute ischaemia reperfusion injury in skeletal muscle'
Dillon, JP,Laing, AJ,Cahill, RA,O'Brien, GC,Street, JT,Wang, JH,Mc Guinness, A,Redmond, HP; (2005) 'Activated protein C attenuates acute ischaemia reperfusion injury in skeletal muscle'. Rna-A Publication of The Rna Society, 23 :1454-1459 [DOI] [Details]
(2005)'Bacterial lipoprotein induces resistance to gram-negative sepsis in TLR4-deficient mice via enhanced bacterial clearance'
O'Brien, GC,Wang, JH,Redmond, HP; (2005) 'Bacterial lipoprotein induces resistance to gram-negative sepsis in TLR4-deficient mice via enhanced bacterial clearance'. Journal of Immunology, 174 :1020-1026 [Details]
(2005)'Activated endothelial interleukin-1 beta, -6, and -8 concentrations and intercellular adhesion molecule-1 expression are attenuated by lidocaine'
Lan, W,Harmon, DC,Wang, JH,Shorten, GD,Redmond, PH; (2005) 'Activated endothelial interleukin-1 beta, -6, and -8 concentrations and intercellular adhesion molecule-1 expression are attenuated by lidocaine'. Anesthesia and Analgesia, 100 :409-412 [DOI] [Details]
(2004)'Hypertonic saline impedes tumor cell-endothelial cell interaction by reducing adhesion molecule and laminin expression'
Shields, CJ,Winter, DC,Wang, JH,Andrews, E,Laug, WE,Redmond, HP; (2004) 'Hypertonic saline impedes tumor cell-endothelial cell interaction by reducing adhesion molecule and laminin expression'. Journal of Surgery, 136 :76-83 [DOI] [Details]
(2004)'Surgical injury induces the mobilization of endothelial progenitor cells'
Condon, ET,Wang, JH,Redmond, HP; (2004) 'Surgical injury induces the mobilization of endothelial progenitor cells'. Journal of Surgery, 135 :657-661 [DOI] [Details]
(2004)'Bacterial lipoprotein delays apoptosis in human neutrophils through inhibition of caspase-3 activity: Regulatory roles for CD14 and TLR-2'
Power, CP,Wang, JH,Manning, B,Kell, MR,Aherne, NF,Wu, QD,Redmond, HP; (2004) 'Bacterial lipoprotein delays apoptosis in human neutrophils through inhibition of caspase-3 activity: Regulatory roles for CD14 and TLR-2'. Journal of Immunology, 173 :5229-5237 [Details]
(2004)'The effect of lidocaine on in vitro neutrophil and endothelial adhesion molecule expression induced by plasma obtained during tourniquet-induced ischaemia and reperfusion'
Lan, W,Harmon, D,Wang, JH,Ghori, K,Shorten, G,Redmond, P; (2004) 'The effect of lidocaine on in vitro neutrophil and endothelial adhesion molecule expression induced by plasma obtained during tourniquet-induced ischaemia and reperfusion'. European Journal of Anaesthesiology, 21 :892-897 [Details]
(2004)'The effect of lidocaine on neutrophil CD11b/CD18 and endothelial ICAM-1 expression and IL-1 beta concentrations induced by hypoxia-reoxygenation'
Lan, W,Harmon, D,Wang, JH,Shorten, G,Redmond, P; (2004) 'The effect of lidocaine on neutrophil CD11b/CD18 and endothelial ICAM-1 expression and IL-1 beta concentrations induced by hypoxia-reoxygenation'. European Journal of Anaesthesiology, 21 :967-972 [Details]
(2003)'Endotoxin/lipopolysaccharide activates NF-kappa B and enhances tumor cell adhesion and invasion through a beta(1) integrin-dependent mechanism'
Wang, JH,Manning, BJ,Wu, QD,Blankson, S,Bouchier-Hayes, D,Redmond, HP; (2003) 'Endotoxin/lipopolysaccharide activates NF-kappa B and enhances tumor cell adhesion and invasion through a beta(1) integrin-dependent mechanism'. Journal of Immunology, 170 :795-804 [Details]
(2003)'Excisional surgery for cancer cure: therapy at a cost'
Coffey, JC,Wang, JH,Smith, MJF,Bouchier-Hayes, D,Cotter, TG,Redmond, HP; (2003) 'Excisional surgery for cancer cure: therapy at a cost'. The Lancet Oncology, 4 :760-768 [Details]
(2002)'Induction of bacterial lipoprotein tolerance is associated with suppression of Toll-like receptor 2 expression'
Wang, JH,Doyle, M,Manning, BJ,Wu, QD,Blankson, S,Redmond, HP; (2002) 'Induction of bacterial lipoprotein tolerance is associated with suppression of Toll-like receptor 2 expression'. The Journal of Biological Chemistry, 277 :36068-36075 [DOI] [Details]
(2002)'The role of COX-2 inhibitors in lung cancer'
Qadri, SSA,Wang, JH,Redmond, KC,O'Donnell, AF,Aherne, T,Redmond, HP; (2002) 'The role of COX-2 inhibitors in lung cancer'. The Annals of Thoracic Surgery, 74 :1648-1652 [DOI] [Details]
(2001)'Role of taurine in preventing acetaminophen-induced hepatic injury in the rat'
Waters, E,Wang, JH,Redmond, HP,Wu, QD,Kay, E,Bouchier-Hayes, D; (2001) 'Role of taurine in preventing acetaminophen-induced hepatic injury in the rat'. The American Journal of Physiology, 280 :1274-1279 [Details]
(2001)'Human neutrophils facilitate tumor cell transendothelial migration'
Wu, QD,Wang, JH,Condron, C,Bouchier-Hayes, D,Redmond, HP; (2001) 'Human neutrophils facilitate tumor cell transendothelial migration'. Cell, 280 :814-822 [Details]
(2001)'Sodium hyaluronate enhances colorectal tumour cell metastatic potential in vitro and in vivo'
Tan, B,Wang, JH,Wu, QD,Kirwan, WO,Redmond, HP; (2001) 'Sodium hyaluronate enhances colorectal tumour cell metastatic potential in vitro and in vivo'. Journal of Surgery, 88 :246-250 [Details]
(2000)'Does chronic occupational exposure to volatile anesthetic agents influence the rate of neutrophil apoptosis?'
Goto, Y,Gallagher, J,Fanning, N,Wang, JH,McCusker, S,Redmond, P,Shorten, G; (2000) 'Does chronic occupational exposure to volatile anesthetic agents influence the rate of neutrophil apoptosis?'. Canadian Journal of Anaesthesia, 47 :350-353 [Details]
(1999)'Taurine prevents high-glucose-induced human vascular endothelial cell apoptosis'
Di Wu, Q,Wang, JH,Fennessy, F,Redmond, HP,Bouchier-Hayes, D; (1999) 'Taurine prevents high-glucose-induced human vascular endothelial cell apoptosis'. Cell, 277 :1229-1238 [Details]
(1999)'Involvement of tyrosine protein kinase in INF-gamma-induced human endothelial cell apoptosis'
Wang, JH,Redmond, HP,Watson, RWG,Condron, C,Bouchier-Hayes, D; (1999) 'Involvement of tyrosine protein kinase in INF-gamma-induced human endothelial cell apoptosis'. Shock, 11 :311-318 [Details]
(2000)'Is human fracture hematoma inherently angiogenic?'
Street, J,Winter, D,Wang, JH,Wakai, A,McGuinness, A,Redmond, HP (2000) 'Is human fracture hematoma inherently angiogenic?'. Clinical Orthopaedics and Related Research, :224-237 [Details]
(2012)'B7-H3 Participates in the Development of Experimental Pneumococcal Meningitis by Augmentation of the Inflammatory Response via a TLR2-Dependent Mechanism'
Chen, XQ,Quinn, EM,Ni, H,Wang, J,Blankson, S,Redmond, HP,Wang, JH,Feng, X (2012) 'B7-H3 Participates in the Development of Experimental Pneumococcal Meningitis by Augmentation of the Inflammatory Response via a TLR2-Dependent Mechanism'. Journal of immunology (Baltimore, Md. : 1950), 189 :347-355 [DOI] [Details]
(2012)'Bacterial lipoprotein-induced tolerance is reversed by overexpression of IRAK-1'
Li, CH,Liu, JH,An, MB,Redmond, HP,Wang, JH (2012) 'Bacterial lipoprotein-induced tolerance is reversed by overexpression of IRAK-1'. Immunology And Cell Biology, 90 :314-320 [DOI] [Details]
(2011)'Bacterial Superantigens Enhance the In Vitro Proinflammatory Response and In Vivo Lethality of the TLR2 Agonist Bacterial Lipoprotein'
Kearney, DE,Wang, W,Redmond, HP,Wang, JH (2011) 'Bacterial Superantigens Enhance the In Vitro Proinflammatory Response and In Vivo Lethality of the TLR2 Agonist Bacterial Lipoprotein'. Journal of Immunology, 187 :5363-5369 [DOI] [Details]
(2011)'Bacterial lipoprotein-induced tolerance is reversed by overexpression of IRAK-1'
Li CH, Liu J, An M, Redmond HP, Wang JH ; (2011) 'Bacterial lipoprotein-induced tolerance is reversed by overexpression of IRAK-1'. [Details]
(2011)'Increased Susceptibility of ST2-Deficient Mice to Polymicrobial Sepsis Is Associated with an Impaired Bactericidal Function'
Buckley, JM,Liu, JH,Li, CH,Blankson, S,Di Wu, Q,Jiang, Y,Redmond, HP,Wang, JH (2011) 'Increased Susceptibility of ST2-Deficient Mice to Polymicrobial Sepsis Is Associated with an Impaired Bactericidal Function'. Journal of Immunology, 187 :4293-4299 [DOI] [Details]
(2010)'B7-H3 Augments the Inflammatory Response and Is Associated with Human Sepsis'
Zhang, GB,Wang, JA,Kelly, J,Gu, GH,Hou, JQ,Zhou, YH,Redmond, HP,Wang, JH,Zhang, XG; (2010) 'B7-H3 Augments the Inflammatory Response and Is Associated with Human Sepsis'. Journal of Immunology, 185 :3677-3684 [DOI] [Details]
(2010)'Lipomatosis: an unusual side-effect of cytotoxic chemotherapy?'
Cronin PA, Wang JH, Redmond HP; (2010) 'Lipomatosis: an unusual side-effect of cytotoxic chemotherapy?'. 90 (3):303-304 [Details]
(2010)'The antiendotoxin agent taurolidine potentially reduces ischemia/reperfusion injury through its metabolite taurine'
Doddakula, KK,Neary, PM,Wang, JH,Sookhai, S,O'Donnell, A,Aherne, T,Bouchier-Hayes, DJ,Redmond, HP; (2010) 'The antiendotoxin agent taurolidine potentially reduces ischemia/reperfusion injury through its metabolite taurine'. Journal of Surgery, 148 :567-572 [DOI] [Details]
(2010)'Surgical Injury enhances the expression of genes that mediate breast cancer metastasis to the lung'
Al Sahaf O, Wang JH, Browne TJ, Cotter TG, Redmond HP; (2010) 'Surgical Injury enhances the expression of genes that mediate breast cancer metastasis to the lung'. Annals of surgery, 252 (6):1037-1043 [Details]
(2010)'Surgical Injury Enhances the Expression of Genes That Mediate Breast Cancer Metastasis to the Lung'
Al-Sahaf, O,Wang, JH,Browne, TJ,Cotter, TG,Redmond, HP; (2010) 'Surgical Injury Enhances the Expression of Genes That Mediate Breast Cancer Metastasis to the Lung'. Annals of Surgery, 252 :1037-1043 [DOI] [Details]
(2009)'p38 MAP Kinase Inhibition Promotes Primary Tumour Growth via VEGF Independent Mechanism'
O'Sullivan AW, Wang JH, Redmond HP ; (2009) 'p38 MAP Kinase Inhibition Promotes Primary Tumour Growth via VEGF Independent Mechanism'. 15 (7) [Details]
(2009)'The Role of P38 MAPK and PKC in BLP Induced TNF-alpha Release, Apoptosis, and NF kappa B Activation in THP-1 Monocyte Cells'
O'Sullivan, AW,Wang, JH,Redmond, HP (2009) 'The Role of P38 MAPK and PKC in BLP Induced TNF-alpha Release, Apoptosis, and NF kappa B Activation in THP-1 Monocyte Cells'. Journal of Surgical Research, 151 :138-144 [DOI] [Details]
(2009)'P38 MAP Kinase inhibition promotes primary tumour growth via VEGF independent mechanism'
O'Sullivan, AW,Wang, JH,Redmond, HP (2009) 'P38 MAP Kinase inhibition promotes primary tumour growth via VEGF independent mechanism'. World Journal Of Surgical Oncology, 7 [DOI] [Details]
(2009)'Analysis of differential gene expression in colorectal cancer and stroma using fluorescence-activated cell sorting purification'
Smith MJ, Culhane AC, Donovan M, Coffey JC, Barry BD, Kelly MA, Higgins DG, Wang JH, Kirwan WO, Cotter TG, Redmond HP; (2009) 'Analysis of differential gene expression in colorectal cancer and stroma using fluorescence-activated cell sorting purification'. British Journal of Cancer, 100 (9):1452-1464 [DOI] [Details]
(2008)'Mechanisms driving local breast cancer recurrence in a model of breast-conserving surgery'
Smith MJ, Culhane AC, Killeen S, Kelly MA, Wang JH, Cotter TG, Redmond HP; (2008) 'Mechanisms driving local breast cancer recurrence in a model of breast-conserving surgery'. Annals of Surgical Oncology, 15 (10):2954-2964 [DOI] [Details]
(2008)'Hypertonic saline reduces skeletal muscle injury and associated remote organ injury following ischemia reperfusion injury'
Dillon, JP,Laing, AJ,Chandler, JR,Shields, CJ,Wang, JH,McGuinness, A,Redmond, HP (2008) 'Hypertonic saline reduces skeletal muscle injury and associated remote organ injury following ischemia reperfusion injury'. Acta Orthopaedica, 79 :703-707 [DOI] [Details]
(2008)'Statins attenuate polymethylmethacrylate-mediated monocyte activation'
Laing, AJ,Dillon, JP,Mulhall, KJ,Wang, JH,McGuinness, AJ,Redmond, PH (2008) 'Statins attenuate polymethylmethacrylate-mediated monocyte activation'. Acta Orthopaedica, 79 :134-140 [DOI] [Details]
(2007)'Mobilization of endothelial precursor cells: Systemic vascular response to musculoskeletal trauma'
Laing, AJ,Dillon, JP,Condon, ET,Street, JT,Wang, JH,McGuinness, AJ,Redmond, HP (2007) 'Mobilization of endothelial precursor cells: Systemic vascular response to musculoskeletal trauma'. Journal Of Orthopaedic Research, 25 :44-50 [DOI] [Details]
(2007)'A systemic provascular response in bone marrow to musculoskeletal trauma in mice'
Laing, AJ,Dillon, JP,Condon, ET,Coffey, JC,Street, JT,Wang, JH,McGuinness, AJ,Redmond, HP (2007) 'A systemic provascular response in bone marrow to musculoskeletal trauma in mice'. The Journal of Bone and Joint Surgery, 89B :116-120 [DOI] [Details]
(2006)'The targeting of phosphoinositide-3 kinase attenuates pulmonary metastatic tumor growth following laparotomy'
Coffey JC, Wang JH, Bouchier-Hayes D, Cotter TG, Redmond HP; (2006) 'The targeting of phosphoinositide-3 kinase attenuates pulmonary metastatic tumor growth following laparotomy'. Annals of Surgery, 243 (2):250-256 [DOI] [Details]
(2006)'Exploitation of the Toll-like receptor system in cancer: a doubled-edged sword?'
Killeen SD, Wang JH, Andrews EJ, Redmond HP; (2006) 'Exploitation of the Toll-like receptor system in cancer: a doubled-edged sword?'. British Journal of Cancer, 95 (3):247-252 [DOI] [Details]
(2006)'Cancer surgery: risks and opportunities'
Coffey JC, Smith MJ, Wang JH, Bouchier-Hayes D, Cotter TG, Redmond HP; (2006) 'Cancer surgery: risks and opportunities'. News and Reviews In Molecular, Cellular and Developmental Biology, 28 (4):433-437 [DOI] [Details]
(2006)'Pravastatin attenuates tourniquet-induced skeletal muscle ischemia reperfusion injury'
Dillon, JP,Laing, AJ,Chandler, JRS,Wang, JH,McGuinness, A,Redmond, FP (2006) 'Pravastatin attenuates tourniquet-induced skeletal muscle ischemia reperfusion injury'. Acta Orthopaedica, 77 :27-32 [DOI] [Details]
(2006)'Mast cells facilitate local VEGF release as an early event in the pathogenesis of postoperative peritoneal adhesions'
Cahill, RA,Wang, JH,Soohkai, S,Redmond, HP (2006) 'Mast cells facilitate local VEGF release as an early event in the pathogenesis of postoperative peritoneal adhesions'. Journal of Surgery, 140 :108-112 [DOI] [Details]
(2006)'Cancer surgery: risks and opportunities'
Coffey, JC,Smith, MJF,Wang, JH,Bouchier-Hayes, D,Cotter, TG,Redmond, HP (2006) 'Cancer surgery: risks and opportunities'. Bioessays, 28 :433-437 [DOI] [Details]
(2005)'Activated protein C attenuates acute ischaemia reperfusion injury in skeletal muscle'
Dillon JP, Lang AJ, Cahill RA, O'Brien GC, Street JT, Wang JH, McGuinness A, Redmond HP; (2005) 'Activated protein C attenuates acute ischaemia reperfusion injury in skeletal muscle'. 23 (6):1454-1459 [Details]
(2005)'Phosphoinositide 3-kinase accelerates postoperative tumor growth by inhibiting apoptosis and enhancing resistance to chemotherapy-induced apoptosis. Novel role for an old enemy'
Coffey JC, Wang JH, Smith MJ, Laing A, Bouchier-Hayes D, Cotter TG, Redmond HP; (2005) 'Phosphoinositide 3-kinase accelerates postoperative tumor growth by inhibiting apoptosis and enhancing resistance to chemotherapy-induced apoptosis. Novel role for an old enemy'. The Journal of Biological Chemistry, 280 (22):20968-20977 [DOI] [Details]
(2005)'Bacterial lipoprotein induces resistance to Gram-negative sepsis in TLR4-deficient mice via enhanced bacterial clearance'
O'Brien GC, Wang JH, Redmond HP; (2005) 'Bacterial lipoprotein induces resistance to Gram-negative sepsis in TLR4-deficient mice via enhanced bacterial clearance'. Journal of Immunology, 174 (2):229-235 [Details]
(2005)'Phosphoinositide 3-kinase accelerates postoperaive tumor growth by inhibiting apoptosis and enchancing resistance to chemotherapy-induced apoptosis. Novel role for an old enemy'
Coffey JC, Wang JH, Smith MJ, Laing A, Bouchier-Hayes D, Cotter TG, Redmond HP; (2005) 'Phosphoinositide 3-kinase accelerates postoperaive tumor growth by inhibiting apoptosis and enchancing resistance to chemotherapy-induced apoptosis. Novel role for an old enemy'. Journal of Biological Chemistry, 280 (22):20968-20977 [Details]
(2005)'Activated endothelial IL-1beta and -8 concentrations and ICAM-1 expression are attenuated by lidocaine'
Lan W, Harmon DC, Wang JH, Shorten GD, Redmond HP; (2005) 'Activated endothelial IL-1beta and -8 concentrations and ICAM-1 expression are attenuated by lidocaine'. Anesthesia and Analgesia, [Details]
(2005)'Surgically induced accelerated local and distant tumor growth is significantly attenuated by selective COX-2 inhibition'
Qadri SS, Wang JH, Coffey JC, Alam M, O'Donnell A, Aherne T, Redmond HP; (2005) 'Surgically induced accelerated local and distant tumor growth is significantly attenuated by selective COX-2 inhibition'. 79 (3):990-995 [Details]
(2005)'Phosphoinositide 3-kinase accelerates postoperative tumor growth by inhibiting apoptosis and enhancing resistance to chemotherapy-induced apoptosis'
Coffey, JC,Wang, JH,Smith, MJF,Laing, A,Bouchier-Hayes, D,Cotter, TG,Redmond, HP (2005) 'Phosphoinositide 3-kinase accelerates postoperative tumor growth by inhibiting apoptosis and enhancing resistance to chemotherapy-induced apoptosis'. The Journal of Biological Chemistry, 280 :20968-20977 [Details]
(2005)'Can surgery for cancer accelerate the progresssion of secondary tumours within residual minimal disease at both local and systemic levels'
Qadri SS, Wang JH, Coffey JC, Alam M, O'Donnell A, Aherne T, Redmond HP; (2005) 'Can surgery for cancer accelerate the progresssion of secondary tumours within residual minimal disease at both local and systemic levels'. 80 (3):1046-1050 [Details]
(2004)'The effect of lidocaine on neutrophil CD11b/CD18 and endothelial ICAM-1 expression and IL-1beta concentrations induced by hypoxia reoxygenation'
Lan W, Harmon D, Wang JH, Shorten G, Redmond HP; (2004) 'The effect of lidocaine on neutrophil CD11b/CD18 and endothelial ICAM-1 expression and IL-1beta concentrations induced by hypoxia reoxygenation'. European Journal of Anaesthesiology, [Details]
(2004)'The effect of lidocaine on in vitro neutrophil and endothelial adhesion molecule expression induced by plasma obtained during tourniquet-induced ischaemia and reperfusion'
Lan W, Harmon D, Wang JH, Ghori K, Shorten G, Redmond P; (2004) 'The effect of lidocaine on in vitro neutrophil and endothelial adhesion molecule expression induced by plasma obtained during tourniquet-induced ischaemia and reperfusion'. European Journal of Anaesthesiology, 21 (11):892-897 [Details]
(2004)'Surgical injury induces the mobilization of endothelial progenitor cells'
Condon ET, Wang JH, Redmond HP; (2004) 'Surgical injury induces the mobilization of endothelial progenitor cells'. 135 (6):657-661 [Details]
(2004)'Hypertonic saline impedes tumor cell-endothelial cell interaction by reducing adhesion molecule and laminin expression'
Shields CJ, Winter DC, Wang JH, Andrews E, Laug WE, Redmond HP; (2004) 'Hypertonic saline impedes tumor cell-endothelial cell interaction by reducing adhesion molecule and laminin expression'. 136 (1):76-83 [Details]
(2004)'Significance of toll-like receptors in the pathophysiology of surgical sepsis'
Romics L Jr, Coffey JC, Wang JH, Redmond HP, Szabo G; (2004) 'Significance of toll-like receptors in the pathophysiology of surgical sepsis'. 57 (4):229-235 [Details]
(2004)'Bacterial lipoprotein delays apoptosis in human neutrophils through inhibition of caspase-3 activity: regulatory roles for CD14 and TLR-2'
Power CP, Wang JH, Manning B, Kell MR, Aherne NF, Wu QD, Redmond HP; (2004) 'Bacterial lipoprotein delays apoptosis in human neutrophils through inhibition of caspase-3 activity: regulatory roles for CD14 and TLR-2'. Journal of Immunology, 173 (8):5229-5237 [Details]
(2004)'The effect of lidocaine on in vitro neutrophil and endothelial adhesion molecule expression induced by plasma obtained during tourniquet -induced ischaemia and reperfusion'
Lan W, Harmon D, Wang JH, Ghori K, Shorten G, Redmond HP; (2004) 'The effect of lidocaine on in vitro neutrophil and endothelial adhesion molecule expression induced by plasma obtained during tourniquet -induced ischaemia and reperfusion'. European Journal of Anaesthesiology, [Details]
(2003)'Hypertonic saline infusion for pulmonary injury due to ischaemia-reperfusion'
Shields CJ, Winter DC, Manning BJ, Wang JH, Kirwan WO, Redmond HP; (2003) 'Hypertonic saline infusion for pulmonary injury due to ischaemia-reperfusion'. 138 (1):9-14 [Details]
(2003)'Inductioin of angiogenic cytokine expression in cultured RPE by ingestion of oxidized photoreceptor outer segments'
Higgins GT, Wang JH, Dockery P, Cleary PE, Redmond HP; (2003) 'Inductioin of angiogenic cytokine expression in cultured RPE by ingestion of oxidized photoreceptor outer segments'. 44 (4):1775-1782 [Details]
(2003)'Effect of sevoflurane on human neutrophil apoptosis'
Tyther R, O'Brien J, Wang JH, Redmond HP, Shorten G; (2003) 'Effect of sevoflurane on human neutrophil apoptosis'. European Journal of Anaesthetics, 20 (2):111-115 [Details]
(2003)'Gene expression profiling in biliary atresia'
Smith MJ, Coffey JC, Wang JH, Cotter TG, Redmond HP; (2003) 'Gene expression profiling in biliary atresia'. Lancet, 361 (9361):971-972 [Details]
(2003)'Excisional surgery for cancer cure: therapy at a cost'
Coffey, JC; Wang, JH; Smith, MJ; Bochier-Hayes, D; Cotter, TG; Redmond, HP; (2003) 'Excisional surgery for cancer cure: therapy at a cost'. Lancet, 4 (12):295-303 [Details]
(2003)'Endotoxin/lipopolysaccharide activates NF-kappa B and enhances tumour cell adhesion and invasion through a beta 1 integrin-dependent mechanism'
Wang JH, Manning BJ, Wu QD, Blankson S, Bouchier-Hayes D, Redmond HP; (2003) 'Endotoxin/lipopolysaccharide activates NF-kappa B and enhances tumour cell adhesion and invasion through a beta 1 integrin-dependent mechanism'. Journal of Immunology, 170 (2):795-804 [Details]
(2003)'Bacterial lipoprotein induces endotoxin-independent tolerance to septic shock'
Wang, JH,Doyle, M,Manning, BJ,Blankson, S,Wu, QD,Power, C,Cahill, R,Redmond, HP (2003) 'Bacterial lipoprotein induces endotoxin-independent tolerance to septic shock'. Journal of immunology (Baltimore, Md. : 1950), 170 :14-18 [Details]
(2003)'Excisional surgery for cancer cure: therapy at a cost'
Coffey JC, Wang JH, Smith MJ, Bouchier-Hayes D, Cotter TG, Redmond HP; (2003) 'Excisional surgery for cancer cure: therapy at a cost'. The Lancet Oncology, 4 (12):760-768 [Details]
(2003)'Hypertonic saline enhances host response to bacterial challenge by augmenting receptor-independent neutrophil intracellular superoxide formation'
Shields CJ, O'Sullivan AW, Wang JH, Winter DC, Kirwan WO, Redmond HP; (2003) 'Hypertonic saline enhances host response to bacterial challenge by augmenting receptor-independent neutrophil intracellular superoxide formation'. 238 (2):249-257 [Details]
(2003)'Cutting edge: bacterial lipoprotein induces endotoxin-independent tolerence to septic shock'
Wang JH, Doyle M, Manning BJ, Blankson S, Wu QD, Power C, Cahill R, Redmond HP; (2003) 'Cutting edge: bacterial lipoprotein induces endotoxin-independent tolerence to septic shock'. Journal of Immunology, 170 (1):14-18 [Details]
(2003)'Hypertonic saline enhances host response to bacterial challenge by augmenting receptor-independent neutrophil intracellular superoxide formation'
Shields, CJ,O'Sullivan, AW,Wang, JH,Winter, DC,Kirwan, WO,Redmond, HP (2003) 'Hypertonic saline enhances host response to bacterial challenge by augmenting receptor-independent neutrophil intracellular superoxide formation'. Annals of Surgery, 238 :249-257 [DOI] [Details]
(2003)'Excisional surgery for cancer cure: therapy at a cost?'
Coffey JC, Wang JH, Smith MJ, Bouchier-Hayes D, Cotter TG, Redmond HP; (2003) 'Excisional surgery for cancer cure: therapy at a cost?'. 4 (12):760-768 [Details]
(2003)'Gene expression profiling in biliary atresia'
Smith MJ, Coffey JC, Wang JH, Cotter TG, Redmond HP; (2003) 'Gene expression profiling in biliary atresia'. Lancet, 361 (9361):971-91 [Details]
(2002)'Induction of bacterial lipoprotein tolerance is associated with suppression of toll-like receptor 2 expression'
Wang JH, Doyle M, Manning BJ, Wu QD, Blankson S, Redmond HP; (2002) 'Induction of bacterial lipoprotein tolerance is associated with suppression of toll-like receptor 2 expression'. 277 (39):36068-36075 [Details]
(2002)'The role of COX-2 inhibitors in lung cancer'
Qadri SS, Wang JH, Redmond KC, O'Donnell AF, Aherne T, Redmond HP; (2002) 'The role of COX-2 inhibitors in lung cancer'. 74 (5):1648-1652 [Details]
(2002)'Role of the neutrophil in the development of systemic inflammatory response syndrome and sepsis following abdominal aortic surgery'
O'Sullivan AW, Wang JH, Redmond HP; (2002) 'Role of the neutrophil in the development of systemic inflammatory response syndrome and sepsis following abdominal aortic surgery'. British Journal of Surgery, 89 (7):938-938 [Details]
(2002)'Soluble interleukin 6 receptor (sIL-6R) mediates colonic tumor cell adherence to the vascular endothelium: A mechanism for metastatic initiation?'
Dowdall, JF,Winter, DC,Andrews, E,Laug, WE,Wang, JH,Redmond, HP (2002) 'Soluble interleukin 6 receptor (sIL-6R) mediates colonic tumor cell adherence to the vascular endothelium: A mechanism for metastatic initiation?'. Journal of Surgical Research, 107 :1-6 [DOI] [Details]
(2002)'Hypoxia upregulates Bcl-2 expression and suppresses interferon-gamma induced antiangiogenic activity in human tumor derived endothelial cells'
Wang JH, Wu QD, Bouchier-Hayes D, Redmond HP; (2002) 'Hypoxia upregulates Bcl-2 expression and suppresses interferon-gamma induced antiangiogenic activity in human tumor derived endothelial cells'. 94 (10):2745-2755 [Details]
(2002)'Perioperative probiotics protect against surgically induced tumour growth'
Coffey, JC and Doyle, M and Wang, JH and O'Mahony, L and Maguire, D and Shanahan, F and Collins, JK and Kirwan, WO and Redmond, HP; (2002) 'Perioperative probiotics protect against surgically induced tumour growth'. ANNALS OF SURGICAL ONCOLOGY, 9 (1, Suppl. S) [Details]
(2002)'Soluble interleukin 6 receptor (sIL-6R) mediates colonic tumor cell adherence to the vascular endothelium: a mechanism for metastatic initiation?'
Dowdall JF, Winter DC, Andrews E, Laug WE, Wang JH, Redmond HP; (2002) 'Soluble interleukin 6 receptor (sIL-6R) mediates colonic tumor cell adherence to the vascular endothelium: a mechanism for metastatic initiation?'. 107 (1):1-6 [Details]
(2002)'Probiotics confer protection against perioperative metastatic tumour growth'
Coffey, JC and Doyle, M and O'Mahony, L and Wang, JH and Maguire, D and Shanahan, F and Collins, K and Kirwan, WO and Redmond, HP; (2002) 'Probiotics confer protection against perioperative metastatic tumour growth'. BRITISH JOURNAL OF SURGERY, 89 (5) [Details]
(2001)'Upregulation of Fas-Fas-L (CD95/CD95L)-mediated epithelial apoptosis - A putative role in pouchitis?'
Coffey, JC and Bennett, MW and Wang, JH and O'Connell, J and Neary, P and Shanahan, F and Redmond, HP and Kirwan, WO; (2001) 'Upregulation of Fas-Fas-L (CD95/CD95L)-mediated epithelial apoptosis - A putative role in pouchitis?'. JOURNAL OF SURGICAL RESEARCH, 98 (1):27-32 [DOI] [Details]
(2001)'Upregulation of Fas-FasL (CD95/CD95L)-mediated epithelial apoptosis in pouchitis'
Bennett, MW and Coffey, JC and Wang, JH and Neary, P and O'Connell, J and Shanahan, F and Redmond, HP and Kirwan, WO; (2001) 'Upregulation of Fas-FasL (CD95/CD95L)-mediated epithelial apoptosis in pouchitis'. GASTROENTEROLOGY, 120 (5, Suppl. 1) [Details]
(2001)'Adenosine inhibits neutrophil vascular endothelial growth factor release and transendothelial migration via A(2B) receptor activation'
Wakai, A,Wang, JH,Winter, DC,Street, JT,O'Sullivan, RG,Redmond, HP (2001) 'Adenosine inhibits neutrophil vascular endothelial growth factor release and transendothelial migration via A(2B) receptor activation'. Shock, 15 :297-301 [Details]
(2001)'The angiogenic response to skeletal injury is preserved in the elderly'
Street JT, Wang JH, Wu QD, Wakai A, McGuinness A, Redmond HP; (2001) 'The angiogenic response to skeletal injury is preserved in the elderly'. 19 (6):1057-1066 [Details]
(2001)'Bacterial wall products induce downregulation of vascular endothelial growth factor receptors on endothelial cells via a CD14-dependent mechanism: Implications for surgical wound healing'
Power, C,Wang, JH,Sookhai, S,Street, JT,Redmond, HP (2001) 'Bacterial wall products induce downregulation of vascular endothelial growth factor receptors on endothelial cells via a CD14-dependent mechanism: Implications for surgical wound healing'. Journal of Surgical Research, 101 :138-145 [DOI] [Details]
(2001)'Upregulation of Fas/FasL (CD95/CD95L)-mediated epithelial apoptosis: a novel therapeutic target in pouchitis'
Coffey, JC and Bennett, MW and Wang, JH and Neary, P and O'Connell, J and Shanahan, F and Redmond, HP and Kirwan, WO; (2001) 'Upregulation of Fas/FasL (CD95/CD95L)-mediated epithelial apoptosis: a novel therapeutic target in pouchitis'. BRITISH JOURNAL OF SURGERY, 88 (5) [Details]
(2001)'Attenuation of pancreatitis-induced pulmonary injury by aerosolized hypertonic saline'
Shields CJ, Sookhai S, Winter DC, Dowdall JF, Kingston G, Parfrey N, Wang JH, Kirwan WO, Redmond HP; (2001) 'Attenuation of pancreatitis-induced pulmonary injury by aerosolized hypertonic saline'. 2 (3):215-224 [Details]
(2001)'Adenosine inhibits neutrophil vascular endothelial growth factor release and transendothelial migration via A2B receptor activation'
Wakai A, Wang JH, Winter DC, Street JT, O'Sullivan RG, Redmond HP; (2001) 'Adenosine inhibits neutrophil vascular endothelial growth factor release and transendothelial migration via A2B receptor activation'. 15 (4):297-301 [Details]
(2001)'Human neutrophils facilitate tumor cell transendothelial migration'
Wu QD, Wang JH, Condron C, Bouchier-Hayes D, Redmond HP; (2001) 'Human neutrophils facilitate tumor cell transendothelial migration'. 280 (4):C814-C822 [Details]
(2001)'Upregulation of Fas-Fas-L (CD95/CD95L)-mediated epithelial apoptosis- a putative role in pouchitis?'
Coffey JC, Bennett MW, Wang JH, O'Connell J, Neary P, Shanahan F, Redmond HP, Kirwan WO; (2001) 'Upregulation of Fas-Fas-L (CD95/CD95L)-mediated epithelial apoptosis- a putative role in pouchitis?'. 98 (1):27-32 [Details]
(2001)'Role of taurine in preventing acetaminophen-induced hepatic injury in the rat'
Waters E, Wang JH, Redmond HP, Wu QD, Kay E, Bouchier-Hayes D; (2001) 'Role of taurine in preventing acetaminophen-induced hepatic injury in the rat'. 280 (6):G1274-G1279 [Details]
(2001)'The effect of lidocaine on neutrophil respiratory burst during induction of general anaesthesia and tracheal intubation'
Swanton BJ, Iohom G, Wang JH, Redmond HP, Shorten GD; (2001) 'The effect of lidocaine on neutrophil respiratory burst during induction of general anaesthesia and tracheal intubation'. European Journal of Anaesthetics, 18 (8):524-529 [Details]
(2001)'Iosine attenautes tourniquet-induced skeletal muscle reperfusion injury'
Wakai A, Winter DC, Street JT, O'Sullivan RG, Wang JH, Redmond HP; (2001) 'Iosine attenautes tourniquet-induced skeletal muscle reperfusion injury'. 99 (2):311-315 [Details]
(2001)'Bacterial wall products induce downregulation of vascular endothelial growth factor receptors on endothelial cells via a CD14-dependent mechanism: implications for surgical wound healing'
Power C, Wang JH, Sookhai S, Street JT, Redmond HP; (2001) 'Bacterial wall products induce downregulation of vascular endothelial growth factor receptors on endothelial cells via a CD14-dependent mechanism: implications for surgical wound healing'. 101 (2):138-145 [Details]
(2001)'Is immunohistochemical analysis an appropriate diagnostic technique for bone marrow micrometastases?'
Redmond KC, Wang JH, Austin KK, Relihan N, McGreal G, Kirwan WO, Richardson D, Kelly J, Redmond HP; (2001) 'Is immunohistochemical analysis an appropriate diagnostic technique for bone marrow micrometastases?'. 19 (15):3589-3592 [Details]
(2001)'Tumor cell adhesion to endothelial cells is increased by endotoxin via an upregulation of beta-1 integrin expression'
Andrews, EJ,Wang, JH,Winter, DC,Laug, WE,Redmond, HP (2001) 'Tumor cell adhesion to endothelial cells is increased by endotoxin via an upregulation of beta-1 integrin expression'. Journal of Surgical Research, 97 :14-19 [DOI] [Details]
(2001)'Tourniquet-induced systemic inflammatory response in extremity surgery'
Wakai A, Wang JH, Winter DC, Street JT, O'Sullivan RG, Redmond HP; (2001) 'Tourniquet-induced systemic inflammatory response in extremity surgery'. 51 (5):922-926 [Details]
(2001)'Proinflammatory effects of bacterial lipoprotein on human neutrophil activation status, function and cytotoxic potential in vitro'
Power C, Wang JH, Sookhai S, Wu QD, Redmond HP; (2001) 'Proinflammatory effects of bacterial lipoprotein on human neutrophil activation status, function and cytotoxic potential in vitro'. 15 (6):461-466 [Details]
(2001)'Tumor cell adhesion to endothelial cells is increased by endotoxin via an upregulation of beta-1 integrin expression'
Andrews WJ, Wang JH, Winter DC, Laug WE, Redmond HP; (2001) 'Tumor cell adhesion to endothelial cells is increased by endotoxin via an upregulation of beta-1 integrin expression'. 97 (1):14-19 [Details]
(2001)'Tumor cell adhesion to endothelial cells is increased by endotoxin via an upregulation of beta-1 integrin expression'
Andrews EJ, Wang JH, Winter DC, Laug WE, Redmond HP; (2001) 'Tumor cell adhesion to endothelial cells is increased by endotoxin via an upregulation of beta-1 integrin expression'. Journal of Surgical Research, 97 (1):14-19 [DOI] [Details]
(2001)'The effect of the anaesthetic agent isoflurane on the rate of neutrophil apoptosis in vitro'
Tyther R, Fanning N, Halligan M, Wang JH, Redmond HP, Shorten G; (2001) 'The effect of the anaesthetic agent isoflurane on the rate of neutrophil apoptosis in vitro'. Irish Journal of Medical Science, 170 (1):41-44 [Details]
(2001)'Proinflammatory effects of bacterial lipoprotein on human neutrophil activation status, function and cytotoxic potential in vitro'
Power, C,Wang, JH,Sookhai, S,Wu, QD,Redmond, HP (2001) 'Proinflammatory effects of bacterial lipoprotein on human neutrophil activation status, function and cytotoxic potential in vitro'. Shock, 15 :461-466 [Details]
(2001)'Sodium hyaluronate enhances colorectal tumour cell metastatic potential in vitro and in vivo'
Tan B, Wang JH, Wu QD, Kirwan WO, Redmond HP; (2001) 'Sodium hyaluronate enhances colorectal tumour cell metastatic potential in vitro and in vivo'. British Journal of Surgery, 88 (2):246-250 [Details]
(2001)'Activated human neutrophils release hepatocyte growth factor/scatter factor'
McCourt, M,Wang, JH,Sookhai, S,Redmond, HP (2001) 'Activated human neutrophils release hepatocyte growth factor/scatter factor'. European Journal of Surgical Oncology, 27 :396-403 [Details]
(2001)'Activated human neutrophils release hepatocyte growth factor/scatter factor'
McCourt M, Wang JH, Sookhai S, Redmond HP; (2001) 'Activated human neutrophils release hepatocyte growth factor/scatter factor'. 27 (4):396-403 [Details]
(2001)'The effect of lidocaine on neutrophil respiratory burst during induction of general anaesthesia and tracheal intubation'
Swanton, BJ,Iohom, G,Wang, JH,Redmond, HP,Shorten, GD (2001) 'The effect of lidocaine on neutrophil respiratory burst during induction of general anaesthesia and tracheal intubation'. European Journal of Anaesthesiology, 18 :524-529 [Details]
(2001)'Tourniquet-induced systemic inflammatory response in extremity surgery'
Wakai, A,Wang, JH,Winter, DC,Street, JT,O'Sullivan, RG,Redmond, HP (2001) 'Tourniquet-induced systemic inflammatory response in extremity surgery'. The Journal of trauma, 51 :922-926 [Details]
(2000)'Is human fracture hematoma inherently angiogenic?'
Street J, Winter D, Wang JH, Wakai A, McGuinness A, Redmond HP; (2000) 'Is human fracture hematoma inherently angiogenic?'. 378 (*):224-237 [Details]
(2000)'Dopamine attenuates the chemoattractant effect of interleukin-8: a novel role in the systemic inflammatory response syndrome'
Sookhai S, Wang JH, Winter D, Power C, Kirwan W, Redmond HP; (2000) 'Dopamine attenuates the chemoattractant effect of interleukin-8: a novel role in the systemic inflammatory response syndrome'. 14 (3):295-299 [Details]
(2000)'Taurolidine inhibits tumor cell growth in vitro and in vivo'
McCourt, M,Wang, JH,Sookhai, S,Redmond, HP (2000) 'Taurolidine inhibits tumor cell growth in vitro and in vivo'. Annals of Surgical Oncology, 7 :685-691 [Details]
(2000)'Priming of neutrophil [Ca2+]1 signalling and oxidative burst by human fracture fluids'
Street JT, Wang JH, Power CJ, Redmond HP; (2000) 'Priming of neutrophil [Ca2+]1 signalling and oxidative burst by human fracture fluids'. 49 (1):167-168 [Details]
(2000)'Neutrophil-induced transmigration of tumour cells treated with tumour-conditioned medium is facilitated by granulocyte-macrophage colony stimulating factor'
Wu QD, Wang JH, Bouchier-Hayes D, Redmond HP; (2000) 'Neutrophil-induced transmigration of tumour cells treated with tumour-conditioned medium is facilitated by granulocyte-macrophage colony stimulating factor'. 166 (5):361-366 [Details]
(2000)'Taurolidine inhibits tumour cell growth in vitro and in vivo'
McCourt M, Wang JH, Sookhai S, Redmond HP; (2000) 'Taurolidine inhibits tumour cell growth in vitro and in vivo'. 7 (9):685-691 [Details]
(1999)'Neutrophil heat shock protien expression and activation correlate with increased apoptosis following transmigration through the endothelial barrier'
Hennigan SM, Wang JH, Redmond HP, Bouchier-Hayes D.; (1999) 'Neutrophil heat shock protien expression and activation correlate with increased apoptosis following transmigration through the endothelial barrier'. 12 (1):32-38 [Details]
(1999)'Taurine prevents high-glucose-induced human vasscular endothelial cell apoptosis'
Wu QD, Wang JH, Fennessy F, Redmond HP, Bouchier-Hayes D; (1999) 'Taurine prevents high-glucose-induced human vasscular endothelial cell apoptosis'. 277 (6 Pt 1):C1229-C1238 [Details]
(1999)'Proinflammatory mediators stimulate neutrophil-directed angiogenesis'
McCourt M, Wang JH, Sookhai S, Redmond HP; (1999) 'Proinflammatory mediators stimulate neutrophil-directed angiogenesis'. 134 (12):1325-1332 [Details]
(1999)'Dopamine induces neutrophil apoptosis through a dopamine D-1 receptor-independent mechanism'
Sookhai S, Wang JH, McCourt M, O'Connell D, Redmond HP; (1999) 'Dopamine induces neutrophil apoptosis through a dopamine D-1 receptor-independent mechanism'. 126 (2):314-322 [Details]
(1999)'Involvement of tyrosine protein kinase in IFN-gamma-induced human endothelial cell apoptosis'
Wang JH, Redmond HP, Watson RW, Condron C, Bouchier-Hayes D; (1999) 'Involvement of tyrosine protein kinase in IFN-gamma-induced human endothelial cell apoptosis'. 11 (5):311-318 [Details]
(1998)'Nitric oxide mediates hepatocyte injury'
Wang JH, Redmond HP, Wu QD, Bouchier-Hayes D; (1998) 'Nitric oxide mediates hepatocyte injury'. 275 (5 Pt 1):G1117-G1126 [Details]
(1997)'Plasma factors augment neutrophil and endothelial cell activation during aortic surgery'
Barry MC, Wang JH, Kelly CJ, Sheehan SJ, Redmond HP, Bouchier-Hayes DJ; (1997) 'Plasma factors augment neutrophil and endothelial cell activation during aortic surgery'. 13 (4):381-387 [Details]
(1997)'Intercellular adhesion molecule-1 (ICAM-1) is expressed on human neutrophils and is essential for neutrophil adherence and aggregation'
Wang JH, Sexton DM, Redmond HP, Watson RW, Croke DT, Bouchier-Hayes D; (1997) 'Intercellular adhesion molecule-1 (ICAM-1) is expressed on human neutrophils and is essential for neutrophil adherence and aggregation'. 8 (5):357-361 [Details]
(1997)'Induction of human endothelial cell apoptosis requires both heat shock and oxidative stress responses'
Wang JH, Redmond HP, Watson RW, Bouchier-Hayes D; (1997) 'Induction of human endothelial cell apoptosis requires both heat shock and oxidative stress responses'. 272 (5 Pt 1):C1543-C1551 [Details]
(1996)'The beneficial effect of taurine on the prevention of human enodthelial cell death'
Wang JH, Redmond HP, Watson RW, Condron C, Bouchier-Hayes D; (1996) 'The beneficial effect of taurine on the prevention of human enodthelial cell death'. 6 (5):331-338 [Details]
(1996)'Mechanism invovled in sodium arsenite-induced apoptosis of human neutrophils'
Watson RW, Redmond HP, Wang JH, Bouchier-Hayes D; (1996) 'Mechanism invovled in sodium arsenite-induced apoptosis of human neutrophils'. 60 (5):625-632 [Details]
(1996)'Neutrophils undergo apoptosis following ingestion of Escherichia coli'
Watson RW, Redmond HP, Wang JH, Condron C, Bouchier-Hayes D; (1996) 'Neutrophils undergo apoptosis following ingestion of Escherichia coli'. 156 (10):3986-3992 [Details]
(1996)'Taurine attenuates nitric oxide- and reactive oxygen intermediate-dependent hepatocyte injury'
Redmond HP, Wang JH, Bouchier-Hayes D; (1996) 'Taurine attenuates nitric oxide- and reactive oxygen intermediate-dependent hepatocyte injury'. 131 (12):1280-1288 [Details]
(1996)'Mechanisms involved in the induction of human endothelial cell necrosis'
Wang JH, Redmond HP, Watson RW, Duggan S, McCarthy J, Barry M, Bouchier-Hayes D; (1996) 'Mechanisms involved in the induction of human endothelial cell necrosis'. 168 (1):91-99 [Details]
(1996)'Bacterial ingestion, tumor necrosis factor-alpha, and heat induce programmed cell death in activated neutrophils'
Watson RW, Redmond HP, Wang JH, Bouchier-Hayes D; (1996) 'Bacterial ingestion, tumor necrosis factor-alpha, and heat induce programmed cell death in activated neutrophils'. 5 (1):47-51 [Details]
(1995)'Role of lipopolysaccharide and tumor necrosis factor-alpha in induction of hepatocyte necrosis'
Wang JH, Redmond HP, Watson RW, Bouchier-Hayes D; (1995) 'Role of lipopolysaccharide and tumor necrosis factor-alpha in induction of hepatocyte necrosis'. 269 (2 Pt 1):G297-G304 [Details]
(1995)'Induction of heat shock protein 72 prevents neutrophil-mediated human endothelial cell necrosis'
Wang JH, Redmond HP, Watson RW, Condron C, Bouchier-Hayes D; (1995) 'Induction of heat shock protein 72 prevents neutrophil-mediated human endothelial cell necrosis'. 130 (12):1260-1265 [Details]

Abstract

 YearPublication
(2000)Does premedication with oral diazepam influence the rate of neutrophil apoptosis?.
Goto, Y,O'Malley, C,Wang, JH,Redmond, P,Shorten, G (2000) Does premedication with oral diazepam influence the rate of neutrophil apoptosis?. Abstract [Details]
(2000)Vascular endothelial growth factor (VEGF) expression by a retinal pigment epithelial (RPE) cell line is down-regulated by UVB in normoxia, but up-regulated in hypoxia.
Higgins, GT,Wang, JH,Cleary, P,Redmond, HP (2000) Vascular endothelial growth factor (VEGF) expression by a retinal pigment epithelial (RPE) cell line is down-regulated by UVB in normoxia, but up-regulated in hypoxia. Abstract [Details]
(2001)Unfractionated heparin attenuates lipopolysaccharide-induced neutrophil activation.
Manning, BJ,Wang, JH,Redmond, HP (2001) Unfractionated heparin attenuates lipopolysaccharide-induced neutrophil activation. Abstract [Details]
(2001)Soluble interleukin 6 receptor mediates colonic tumour cell adherence to vascular endothelium: a mechanism for metastatic initiation.
Dowdall, JF,Winter, DC,Andrews, E,Lauge, WE,Wang, JH,Redmond, HP (2001) Soluble interleukin 6 receptor mediates colonic tumour cell adherence to vascular endothelium: a mechanism for metastatic initiation. Abstract [Details]
(2001)Upregulation of Fas/FasL (CD95/CD95L)-mediated epithelial apoptosis: a novel therapeutic target in pouchitis.
Coffey, JC,Bennett, MW,Wang, JH,Neary, P,O'Connell, J,Shanahan, F,Redmond, HP,Kirwan, WO (2001) Upregulation of Fas/FasL (CD95/CD95L)-mediated epithelial apoptosis: a novel therapeutic target in pouchitis. Abstract [Details]
(2001)Inosine attenuates skeletal muscle reperfusion injury.
Wakai, A,Winter, DC,Street, JT,O'Sullivan, RG,Wang, JH,Redmond, HP (2001) Inosine attenuates skeletal muscle reperfusion injury. Abstract [Details]
(2001)Angiogenic cytokines modulate bone turnover.
Street, JT,Wang, JH,Power, C,Wu, QD,Blankson, S,Wakai, A,Redmond, HP (2001) Angiogenic cytokines modulate bone turnover. Abstract [Details]
(2001)Human fracture haematoma is inherently angiogenic.
Street, JT,Wang, JH,Winter, DC,Wakai, A,Wu, QD,Blankson, S,Redmond, HP (2001) Human fracture haematoma is inherently angiogenic. Abstract [Details]
(2001)Upregulation of Fas-FasL (CD95/CD95L)-mediated epithelial apoptosis in pouchitis.
Bennett, MW,Coffey, JC,Wang, JH,Neary, P,O'Connell, J,Shanahan, F,Redmond, HP,Kirwan, WO (2001) Upregulation of Fas-FasL (CD95/CD95L)-mediated epithelial apoptosis in pouchitis. Abstract [Details]
(2001)Bacterial lipoprotein and lipopolysaccharide tolerance in macrophages is mediated by interleukin 1 receptor-associated kinase phosphorylation.
Austin, KK,Wang, JH,Redmond, KC,Sookhai, S,Redmond, HP (2001) Bacterial lipoprotein and lipopolysaccharide tolerance in macrophages is mediated by interleukin 1 receptor-associated kinase phosphorylation. Abstract [Details]
(2001)Retinal pigment epithelial cells which have phagocytosed preoxidized photoreceptor outer segments express chemotactic and angiogenic cytokines.
Higgins, GT,Wang, JH,Cleary, PE,Redmond, HP (2001) Retinal pigment epithelial cells which have phagocytosed preoxidized photoreceptor outer segments express chemotactic and angiogenic cytokines. Abstract [Details]
(2001)Nuclear factor-kappa B (NF-kappa B activation is required for endotoxin-induced tumour cell adhesion and invasion.
Manning, BJ,Wang, JH,Wu, QD,Redmond, HP (2001) Nuclear factor-kappa B (NF-kappa B activation is required for endotoxin-induced tumour cell adhesion and invasion. Abstract [Details]
(2001)Inhibition of inflammatory signal transduction in bacterial lipoprotein-tolerized human monocytes.
Doyle, M,Wang, JH,Manning, B,Wu, QD,Redmond, HP (2001) Inhibition of inflammatory signal transduction in bacterial lipoprotein-tolerized human monocytes. Abstract [Details]
(2001)Inhibition of inflammatory signal transduction in bacterial lipoprotein (BLP) tolerized human monocytes.
Doyle, M,Wang, JH,Manning, B,Wu, QD,Redmond, HP (2001) Inhibition of inflammatory signal transduction in bacterial lipoprotein (BLP) tolerized human monocytes. Abstract [Details]
(2001)Bacterial wall products enhance tumour cell proliferation and activate tumour cells directly.
Doyle, M,Wang, JH,Wu, QD,Redmond, HP (2001) Bacterial wall products enhance tumour cell proliferation and activate tumour cells directly. Abstract [Details]
(2001)Bacterial lipoprotein induces endotoxin-independent tolerance to septic shock.
Doyle, M,Wang, JH,Walsh, D,Redmond, HP (2001) Bacterial lipoprotein induces endotoxin-independent tolerance to septic shock. Abstract [Details]
(2001)Bacterial wall products enhance tumour cell production of interleukin 6 and vascular endothelial growth factor through nuclear factor-kappa B (NF-kappa B)-dependent and -independent pathways.
Doyle, M,Wang, JH,Redmond, HP (2001) Bacterial wall products enhance tumour cell production of interleukin 6 and vascular endothelial growth factor through nuclear factor-kappa B (NF-kappa B)-dependent and -independent pathways. Abstract [Details]
(2001)Elucidation of signal transduction pathways in bacterial lipoprotein tolerance.
Doyle, M,Wang, JH,Redmond, HP (2001) Elucidation of signal transduction pathways in bacterial lipoprotein tolerance. Abstract [Details]
(2001)Retinal pigment epithelial cells that have phagocytosed pre-oxidized photoreceptor outer segments express chemotactic and angiogenic cytokines.
Higgins, GT,Wang, JH,Dockery, P,Cleary, PE,Redmond, HP (2001) Retinal pigment epithelial cells that have phagocytosed pre-oxidized photoreceptor outer segments express chemotactic and angiogenic cytokines. Abstract [Details]
(2002)Bacterial superantigen enhances wound healing.
Manning, BJ,Kell, MR,Winter, DC,Wang, JH,Kirwan, WO,Redmond, HP (2002) Bacterial superantigen enhances wound healing. Abstract [Details]
(2002)A novel approach to screening epithelial tumour cells.
Redmond, KC,Wang, JH,Austin, KK,McGreal, G,Kirwan, WO,Richardson, D,Kelly, J,Redmond, HP (2002) A novel approach to screening epithelial tumour cells. Abstract [Details]
(2002)Bacterial lipoprotein activates nuclear factor kappa B and delays neutrophil apoptosis via a pathway involving p38 mitogen-activated protein kinase and phosphatidylinositol 3 '-kinase.
Manning, BJ,Wang, JH,Redmond, HP (2002) Bacterial lipoprotein activates nuclear factor kappa B and delays neutrophil apoptosis via a pathway involving p38 mitogen-activated protein kinase and phosphatidylinositol 3 '-kinase. Abstract [Details]
(2002)Novel beneficial effects of anticoagulants on neoplastic processes.
O'Sullivan, IJ,Wu, QD,Wang, JH,Kirwan, WO,Redmond, HP (2002) Novel beneficial effects of anticoagulants on neoplastic processes. Abstract [Details]
(2002)Perioperative probiotics protect against surgically induced tumour growth.
Coffey, JC,Doyle, M,Wang, JH,O'Mahony, L,Maguire, D,Shanahan, F,Collins, JK,Kirwan, WO,Redmond, HP (2002) Perioperative probiotics protect against surgically induced tumour growth. Abstract [Details]
(2002)Endotoxin tolerance reduces nuclear factor kappa B (NF kappa B)transcriptional activity and adhesion in tumor cells.
Manning, BJ,Wang, JH,Redmond, HP (2002) Endotoxin tolerance reduces nuclear factor kappa B (NF kappa B)transcriptional activity and adhesion in tumor cells. Abstract [Details]
(2002)Hypertonic saline impedes tumour cell-endothelial cell interaction by inhibiting adhesion molecule and laminin expression.
Shields, CJ,Wang, JH,Winter, DC,Andrews, EJ,Laug, WE,Kirwan, WO,Redmond, HP (2002) Hypertonic saline impedes tumour cell-endothelial cell interaction by inhibiting adhesion molecule and laminin expression. Abstract [Details]
(2002)Pulmonary injury due to ischaemia-reperfusion is ameliorated by hypertonic saline infusion.
Shields, CJ,Manning, B,Winter, DC,Wang, JH,Kirwan, WO,Redmond, HP (2002) Pulmonary injury due to ischaemia-reperfusion is ameliorated by hypertonic saline infusion. Abstract [Details]
(2002)Bacterial lipoprotein and lipopolysaccharide tolerance in macrophages is mediated by interleukin 1 receptor-associated kinase phosphorylation.
Austin, KK,Wang, JH,Redmond, KC,Sookhai, S,Redmond, HP (2002) Bacterial lipoprotein and lipopolysaccharide tolerance in macrophages is mediated by interleukin 1 receptor-associated kinase phosphorylation. Abstract [Details]
(2002)Hypertonic saline impedes tumour cell-endothelial cell interaction by inhibiting adhesion molecule and laminin expression.
Shields, CJ,Wang, JH,Winter, DC,Andrews, EJ,Laug, WE,Kirwan, WO (2002) Hypertonic saline impedes tumour cell-endothelial cell interaction by inhibiting adhesion molecule and laminin expression. Abstract [Details]
(2002)Lipopolysaccharide pretreatment reduces nuclear factor kappa B transcriptional activity and tumour cell adhesion in response to further stimulation by lipopolysaccharide.
Manning, BJ,Wang, JH,Redmond, HP (2002) Lipopolysaccharide pretreatment reduces nuclear factor kappa B transcriptional activity and tumour cell adhesion in response to further stimulation by lipopolysaccharide. Abstract [Details]
(2002)Probiotics confer protection against perioperative metastatic tumour growth.
Coffey, JC,Doyle, M,O'Mahony, L,Wang, JH,Maguire, D,Shanahan, F,Collins, K,Kirwan, WO,Redmond, HP (2002) Probiotics confer protection against perioperative metastatic tumour growth. Abstract [Details]
(2002)Novel role for toll-like receptor 2 in human neutrophil-mediated bacterial phagocytosis.
Cahill, R,Wang, JH,Power, C,Wu, QD,Blankson, S,Redmond, HP (2002) Novel role for toll-like receptor 2 in human neutrophil-mediated bacterial phagocytosis. Abstract [Details]
(2002)Nuclear factor kappa B (NF kappa B) and p38 MAP kinase inhibition improves survival in endotoxin and polymicrobial models of sepsis.
O'Sullivan, AW,Wang, JH,Redmond, HP (2002) Nuclear factor kappa B (NF kappa B) and p38 MAP kinase inhibition improves survival in endotoxin and polymicrobial models of sepsis. Abstract [Details]
(2002)Laparotomy and laparoscopy differentially affect perioperative tumour angiogenesis.
Condon, ET,Wang, JH,O'Malley, DB,Coffey, JC,Ahern, NJ,Redmond, HP (2002) Laparotomy and laparoscopy differentially affect perioperative tumour angiogenesis. Abstract [Details]
(2002)Surgery does not alter the incidence of circulating tumour cells in the bone marrow of patients with breast carcinoma.
Aherne, NJ,Redmond, KC,Wang, JH,Condon, ET,Kelly, J,Richardson, D,Redmond, HP (2002) Surgery does not alter the incidence of circulating tumour cells in the bone marrow of patients with breast carcinoma. Abstract [Details]
(2002)Improved detection of circulating tumour cells in patients with breast carcinoma.
Redmond, KC,Wang, JH,Austin, KK,McGreal, G,Aherne, N,Kirwan, WO,Richardson, D,Kelly, J,Redmond, HP (2002) Improved detection of circulating tumour cells in patients with breast carcinoma. Abstract [Details]
(2002)The antiendotoxin agent taurolidine inhibits angiogenesis.
O'Sullivan, MJ,Wang, JH,Kirwan, WO,Redmond, HP (2002) The antiendotoxin agent taurolidine inhibits angiogenesis. Abstract [Details]
(2002)The antiendotoxin agent taurolidine inhibits breast cancer in vitro and in vivo.
O'Sullivan, MJ,Wang, JH,Wu, QD,Hayes, T,Kirwan, WO,Redmond, HP (2002) The antiendotoxin agent taurolidine inhibits breast cancer in vitro and in vivo. Abstract [Details]
(2003)Inhibition of phosphatidylinositol T-kinase abrogates tumour acceleration following cytoreductive surgery.
Coffey, JC,Wang, JH,Cotter, TG,Redmond, HP (2003) Inhibition of phosphatidylinositol T-kinase abrogates tumour acceleration following cytoreductive surgery. Abstract [Details]
(2003)PI-3 kinase inhibition protects against perioperative metastatic tumour growth.
Coffey, JC,Wang, JH,Cotter, TG,Redmond, HP (2003) PI-3 kinase inhibition protects against perioperative metastatic tumour growth. Abstract [Details]
(2003)Hypertonic saline potentiates host response to Gram negative sepsis despite disruption of mitogen activated protein kinase activation.
Shields, CJ,O'Sullivan, AW,Wang, JH,Winter, DC,Kirwan, WO,Redmond, HP (2003) Hypertonic saline potentiates host response to Gram negative sepsis despite disruption of mitogen activated protein kinase activation. Abstract [Details]
(2003)Hypertonic saline attenuates tumour cell beta-1 integrin expression by sodium-dependent induction of cytoskeletal rearrangement.
Shields, CJ,Winter, DC,Wang, JH,Kirwan, WO,Redmond, HP (2003) Hypertonic saline attenuates tumour cell beta-1 integrin expression by sodium-dependent induction of cytoskeletal rearrangement. Abstract [Details]
(2003)Cytoreductive surgery enhances tumorogenicity by downregulating mitochondrial apoptosis.
Coffey, JC,Wang, JH,Cotter, TG,Redmond, HP (2003) Cytoreductive surgery enhances tumorogenicity by downregulating mitochondrial apoptosis. Abstract [Details]
(2004)Susceptibilty of TLR4-deficient mice to gram-negative sepsis is attenuated by a TLR2 agonist - Bacterial lipoprotein.
O'Brien, GC,Wang, JH,Brennan, I,Manning, BJ,Redmond, HP (2004) Susceptibilty of TLR4-deficient mice to gram-negative sepsis is attenuated by a TLR2 agonist - Bacterial lipoprotein. Abstract [Details]
(2004)Statins (cerivastatin) improve survival in sepsis due to reduced cytokine level and enhanced bacterial clearance.
Chaudhry, MZ,Wang, JH,Blankson, S,Redmond, HP (2004) Statins (cerivastatin) improve survival in sepsis due to reduced cytokine level and enhanced bacterial clearance. Abstract [Details]
(2004)Correlation between clinical stage, oestrogen receptor status and circulating tumour cell burden in patients with breast cancer.
Kelly, MA,Aherne, NJ,Redmond, KC,Relihan, N,Wang, JH,Kelly, J,Richardson, D,O'Hanlon, D,Redmond, HP (2004) Correlation between clinical stage, oestrogen receptor status and circulating tumour cell burden in patients with breast cancer. Abstract [Details]
(2004)Neutralizing vascular endothelial growth factor (VEGF) attenuates vasculogenesis and tumour growth through impaired endothelial progenitor cell proliferation.
Barry, BD,Condon, E,Wang, JH,Redmond, HP (2004) Neutralizing vascular endothelial growth factor (VEGF) attenuates vasculogenesis and tumour growth through impaired endothelial progenitor cell proliferation. Abstract [Details]
(2004)Correlation between clinical stage, oestrogen receptor (ER) status and circulating tumour cell burden in patients with breast cancer.
Kelly, MA,Aherne, NJ,Redmond, KC,Relihan, N,Wang, JH,Kelly, J,Richardson, D,O'Hanlon, D,Redmond, HP (2004) Correlation between clinical stage, oestrogen receptor (ER) status and circulating tumour cell burden in patients with breast cancer. Abstract [Details]
(2004)Induction of bacterial lipoprotein (BLP) tolerance protects Toll-like receptor (TLR) 4-cleficient mice against Gram-negative sepsis via enhanced bacterial clearance, in a process independent of the neutrophil.
O'Brien, GC,Wang, JH,Manning, BJ,Doyle, M,Redmond, HP (2004) Induction of bacterial lipoprotein (BLP) tolerance protects Toll-like receptor (TLR) 4-cleficient mice against Gram-negative sepsis via enhanced bacterial clearance, in a process independent of the neutrophil. Abstract [Details]
(2004)Nicotine stimulates IL-8 release from human retinal pigment epithelial cells.
Cosgrave, EM,Wang, JH,Cleary, PE,Redmond, HP (2004) Nicotine stimulates IL-8 release from human retinal pigment epithelial cells. Abstract [Details]
(2004)HMGB-1 the principal mediator of late mortality in sepsis, is downregulated in BLP tolerized THP-1 cells.
Coffey, JC,Wang, JH,Kelly, R,Romics, L,Redmond, HP (2004) HMGB-1 the principal mediator of late mortality in sepsis, is downregulated in BLP tolerized THP-1 cells. Abstract [Details]
(2004)NF-kappa B and p38 inhibition augment apoptosis induced by selective cyclooxygenase-2 inhibitor in human lung cancer cells in vitro.
Alam, M,Wang, JH,Qadri, SS,Coffey, JC,O'Donnell, AF,Aherne, T,Redmond, HP (2004) NF-kappa B and p38 inhibition augment apoptosis induced by selective cyclooxygenase-2 inhibitor in human lung cancer cells in vitro. Abstract [Details]
(2004)Cytoreduction of primary tumors attenuate the growth of secondary tumors within residual minimal disease.
Qadri, SS,Wang, JH,Alam, M,Coffey, CJ,O'Donnell, A,Aherne, T,Redmond, HP (2004) Cytoreduction of primary tumors attenuate the growth of secondary tumors within residual minimal disease. Abstract [Details]
(2004)Nuclear factor (NF)-kappa B and p38 mitogen-activated protein (MAP) kinase inhibition augment apoptosis induced by a selective cyclo-oxygenase 2 inhibitor in human lung cancer.
Alam, M,Wang, JH,Qadri, SS,Coffey, JC,O'Donnell, AF,Aherne, T,Redmond, HP (2004) Nuclear factor (NF)-kappa B and p38 mitogen-activated protein (MAP) kinase inhibition augment apoptosis induced by a selective cyclo-oxygenase 2 inhibitor in human lung cancer. Abstract [Details]
(2004)High-mobility group box protein (HMGB) 1 is downregulated by monocyte tolerisation with bacterial lipoprotein.
Coffey, JC,Wang, JH,McCarthy, F,Romics, L,Redmond, HP (2004) High-mobility group box protein (HMGB) 1 is downregulated by monocyte tolerisation with bacterial lipoprotein. Abstract [Details]
(2004)CUH1 - a novel dendritic cell vaccine that protects against surgically induced activation of dormant micrometastases.
Coffey, JC,Shilling, D,Smith, MJF,McCarthy, F,Wang, JH,O'Mahony, L,Kavanagh, E,Cotter, TG,Redmond, HP (2004) CUH1 - a novel dendritic cell vaccine that protects against surgically induced activation of dormant micrometastases. Abstract [Details]
(2005)Multiple HSP dendritic cell vaccination matured with bacterial cytoplasmic membranes inhibits tumor growth and metastases.
Shilling, DA,Smith, MJ,Kelly, MA,Coffey, JC,Wang, JH,OMahony, L,Redmond, HP (2005) Multiple HSP dendritic cell vaccination matured with bacterial cytoplasmic membranes inhibits tumor growth and metastases. Abstract [Details]
(2005)Upregulation of the receptor tyrosine kinase DDR1 may induce AKT activation in a model of local breast cancer recurrence.
Smith, MJ,Kelly, MA,Shilling, DA,Culhane, A,Coffey, JC,Wang, JH,Cotter, TG,Redmond, HP (2005) Upregulation of the receptor tyrosine kinase DDR1 may induce AKT activation in a model of local breast cancer recurrence. Abstract [Details]
(2005)Administration of a perioperative multiple heat shock protein dendritic cell vaccine significantly attenuates recurrent breast cancer growth in vivo.
Smith, MJ,Shilling, DA,Kelly, MA,England, KE,Culhane, A,Wang, JH,O'Mahony, L,Cotter, TG,Redmond, HP (2005) Administration of a perioperative multiple heat shock protein dendritic cell vaccine significantly attenuates recurrent breast cancer growth in vivo. Abstract [Details]
(2005)Administration of a novel perioperative multiple heat shock protein-loaded dendritic cell vaccine significantly attenuates recurrent breast cancer growth in vivo.
Smith, MJ,Shilling, DA,Killeen, S,Kelly, MA,Tyther, R,England, K,Wang, JH,Cotter, TG,O'Mahony, L,Redmond, HP (2005) Administration of a novel perioperative multiple heat shock protein-loaded dendritic cell vaccine significantly attenuates recurrent breast cancer growth in vivo. Abstract [Details]
(2007)Phosphoinositide 3-kinase inhibition negatively regulates both TLR2- and TLR4-mediated proinflammatory responses in murine peritoneal macrophages.
McSwiney, E,Wang, JH,Redmond, HP (2007) Phosphoinositide 3-kinase inhibition negatively regulates both TLR2- and TLR4-mediated proinflammatory responses in murine peritoneal macrophages. Abstract [Details]
(2007)Cellular reprogramming by bacterial lipoprotein is independant of ST2.
Buckley, J,Wang, JH,Redmond, HP (2007) Cellular reprogramming by bacterial lipoprotein is independant of ST2. Abstract [Details]
(2007)Overexpression of IRAK-1, but not TLR2, partly reverses bacterial lipoprotein-induced tolerance.
Li Li, CH,Wang, JH,Redmond, HP (2007) Overexpression of IRAK-1, but not TLR2, partly reverses bacterial lipoprotein-induced tolerance. Abstract [Details]
(2007)Inhibition of phosphoinositide 3-kinase negatively regulates TLR2-and TLR4-mediated proinflammatory response to BLP and LPS respectively, but not Gram-positive or Gram-negative bacteria.
McSwiney, EA,Wang, JH,Redmond, HP (2007) Inhibition of phosphoinositide 3-kinase negatively regulates TLR2-and TLR4-mediated proinflammatory response to BLP and LPS respectively, but not Gram-positive or Gram-negative bacteria. Abstract [Details]
(2009)High Nuclear Expression of CXCR4 Is Associated with Metastases and Decreased Survival in Hormone Sensitive Breast Cancer.
Cronin, PA,O'Connell, F,Wang, JH,Redmond, HP (2009) High Nuclear Expression of CXCR4 Is Associated with Metastases and Decreased Survival in Hormone Sensitive Breast Cancer. Abstract [Details]
(2009)CXCR4 Expression as a Potential Predictive Marker of Metastases in Breast Cancer.
Cronin, PA,O'Connell, F,Wang, JH,Redmond, HP (2009) CXCR4 Expression as a Potential Predictive Marker of Metastases in Breast Cancer. Abstract [Details]
(2009)Flow-activated cell-sorting of primary and metastatic tumour cells expressing green fluorescence protein for gene expression microarray analysis.
Al-Sahaf, O,Wang, JH,Pettigrew, C,Cotter, M,Cotter, TG,Redmond, HP (2009) Flow-activated cell-sorting of primary and metastatic tumour cells expressing green fluorescence protein for gene expression microarray analysis. Abstract [Details]
(2010)OVEREXPRESSION OF IRAK-1 PREVENTS BLP-INDUCED TOLERANCE BYPROMOTING NF-KB P65 NUCLEAR TRANSACTIVATION.
Liu, JH,Li, CH,Redmond, HP,Wang, JH (2010) OVEREXPRESSION OF IRAK-1 PREVENTS BLP-INDUCED TOLERANCE BYPROMOTING NF-KB P65 NUCLEAR TRANSACTIVATION. Abstract [Details]
(2010)UNRAVELLING A NOVEL ROLE OF MYELOID-RELATED PROTEINS 8/14 (MRP 8/14) IN SELF-TOLERANCE AND CROSS-TOLERANCE TO GRAM-NEGATIVE AND GRAM-POSITIVE BACTERIA.
Coveney, AP,Wang, JH,Redmond, HP (2010) UNRAVELLING A NOVEL ROLE OF MYELOID-RELATED PROTEINS 8/14 (MRP 8/14) IN SELF-TOLERANCE AND CROSS-TOLERANCE TO GRAM-NEGATIVE AND GRAM-POSITIVE BACTERIA. Abstract [Details]
(2010)BACTERIAL SUPERANTIGENS ENHANCE THE IN VITRO PRO-INFLAMMATORY CYTOKINE RELEASE AND IN VIVO LETHALITY OF THE TLR2 AGONIST BACTERIAL LIPOPROTEIN.
Kearney, DE,Wang, JH,Redmond, HP (2010) BACTERIAL SUPERANTIGENS ENHANCE THE IN VITRO PRO-INFLAMMATORY CYTOKINE RELEASE AND IN VIVO LETHALITY OF THE TLR2 AGONIST BACTERIAL LIPOPROTEIN. Abstract [Details]
(2010)UNRAVELLING A NOVEL ROLE OF MYELOID-RELATED PROTEINS 8/14 (Mrp 8/14) IN SELF-TOLERANCE AND CROSS TOLERANCE TO GRAM-NEGATIVE AND GRAM-POSITIVE BACTERIA.
Coveney, AP,Wang, JH,Redmond, HP (2010) UNRAVELLING A NOVEL ROLE OF MYELOID-RELATED PROTEINS 8/14 (Mrp 8/14) IN SELF-TOLERANCE AND CROSS TOLERANCE TO GRAM-NEGATIVE AND GRAM-POSITIVE BACTERIA. Abstract [Details]
(2010)SUPERANTIGENS: BACTERIAL TOXINS THAT DISRUPT IMMUNITY.
Kearney, DE,Wang, JH,Redmond, HP (2010) SUPERANTIGENS: BACTERIAL TOXINS THAT DISRUPT IMMUNITY. Abstract [Details]
(2010)CXCR4 and breast cancer, a role in metastases, a therapeutic target and a prognostic marker.
Cronin, PA,O'Connell, F,Wang, JH,Redmond, HP (2010) CXCR4 and breast cancer, a role in metastases, a therapeutic target and a prognostic marker. Abstract [Details]
(2010)THE PERI-OPERATIVE ROLE OF THE ANTINEOPLASTIC AGENT TAUROLIDINE IN COLON CANCER: A PROSPECTIVE MULTICENTRE RANDOMISED CONTROLLED TRIAL.
Neary, PM,Hallihan, P,McCourt, M,O'Riordain, MG,Kirwan, WO,O'Boyle, C,Gough, D,Eustace, JA,Ryan, K,Wang, JH,Redmond, HP (2010) THE PERI-OPERATIVE ROLE OF THE ANTINEOPLASTIC AGENT TAUROLIDINE IN COLON CANCER: A PROSPECTIVE MULTICENTRE RANDOMISED CONTROLLED TRIAL. Abstract [Details]
(2011)Toll-like receptor-4 signalling induces tumour survival and treatment resistance in colon cancer cells via an NADPH oxidase dependent mechanism.
O'Leary, DP,Gough, DR,Wang, JH,Cotter, TG,Redmond, HP (2011) Toll-like receptor-4 signalling induces tumour survival and treatment resistance in colon cancer cells via an NADPH oxidase dependent mechanism. Abstract [Details]
(2011)Toll like receptor 4: a shield for cancer cells and a weapon for host defences.
Ahmed, A,Wang, JH,Redmond, HP (2011) Toll like receptor 4: a shield for cancer cells and a weapon for host defences. Abstract [Details]
(2011)Cellular reprogramming by bacterial lipoprotein rescues ST2-deficient mice from lethal sepsis via acceleration of phagosome maturation.
Wang, JH,Buckley, JM,Liu, JH,Blankson, S,Wu, QD,Redmond, HP (2011) Cellular reprogramming by bacterial lipoprotein rescues ST2-deficient mice from lethal sepsis via acceleration of phagosome maturation. Abstract [Details]
(2011)The inhibition of glycolysis using a pyruvate dehydrogenase kinase II inhibitor reduces melanoma cell resistance in a caspase 9 dependent manner.
O'Leary, DP,Hallihan, P,Wang, JH,Redmond, HP (2011) The inhibition of glycolysis using a pyruvate dehydrogenase kinase II inhibitor reduces melanoma cell resistance in a caspase 9 dependent manner. Abstract [Details]
(2011)Toll like receptor 4-a weapon for host defences and a shield for cancer cells in breast cancer.
Ahmed, A,Wang, JH,Redmond, HP (2011) Toll like receptor 4-a weapon for host defences and a shield for cancer cells in breast cancer. Abstract [Details]
(2011)Toll like receptor 4-a double edged sword between host defences and cancer cells.
Ahmed, A,Wang, JH,Redmond, HP (2011) Toll like receptor 4-a double edged sword between host defences and cancer cells. Abstract [Details]
(2011)Cellular reprogramming by bacterial lipoprotein rescues ST2-deficient mice from lethal sepsis.
Coveney, A,Buckley, JM,Liu, JH,Redmond, HP,Wang, JH (2011) Cellular reprogramming by bacterial lipoprotein rescues ST2-deficient mice from lethal sepsis. Abstract [Details]
(2011)Induction of gram-positive bacterial lipoprotein tolerance up-regulates genes that are involved in anti-microbial function while down-regulates genes responsible for proinflammatory response.
Power, DP,Wang, JH,Redmond, HP (2011) Induction of gram-positive bacterial lipoprotein tolerance up-regulates genes that are involved in anti-microbial function while down-regulates genes responsible for proinflammatory response. Abstract [Details]
(2011)Unravelling a novel role of myeloid-related proteins 8/14 (MRP8/14) in self tolerance and cross tolerance to gram negative and gram positive bacteria.
Coveney, A,Wang, JH,Redmond, HP (2011) Unravelling a novel role of myeloid-related proteins 8/14 (MRP8/14) in self tolerance and cross tolerance to gram negative and gram positive bacteria. Abstract [Details]
(2011)Silencing of TLR4 increases tumour progression and lung metastasis in a murine model of breast cancer.
Ahmed, A,Wang, JH,Redmond, HP (2011) Silencing of TLR4 increases tumour progression and lung metastasis in a murine model of breast cancer. Abstract [Details]
(2011)The peri-operative role of the anti-neoplastic agent taurolidine in colon cancer: A prospective multicenter randomised clinical trial.
Neary, PM,O'Leary, P,Hallihan, P,McCourt, M,O'Riordain, MG,Kirwan, WO,O'Boyle, C,Gough, D,Andrews, E,Eustace, JA,Ryan, K,Wang, JH,Redmond, HP (2011) The peri-operative role of the anti-neoplastic agent taurolidine in colon cancer: A prospective multicenter randomised clinical trial. Abstract [Details]
(2011)Toll Like Receptor 4-Weapon or Shield - a Murine Breast Cancer Study.
Ahmed, A,Wang, JH,Redmond, HP (2011) Toll Like Receptor 4-Weapon or Shield - a Murine Breast Cancer Study. Abstract [Details]
(2011)The inhibition of glycolysis using a pyruvate dehydrogenase kinase II inhibitor induces apoptosis and sensitises melanoma cells to temozolomide.
O'Leary, DP,Hallihan, P,Wang, JH,Redmond, HP (2011) The inhibition of glycolysis using a pyruvate dehydrogenase kinase II inhibitor induces apoptosis and sensitises melanoma cells to temozolomide. Abstract [Details]
(2012)Toll-like receptor 4 signalling facilitates metastasis and confers chemoresistance via Nox generated reactive oxygen species in colon cancer.
O'Leary, DP,Bhatt, L,Wang, JH,Cotter, TG,Redmond, HP (2012) Toll-like receptor 4 signalling facilitates metastasis and confers chemoresistance via Nox generated reactive oxygen species in colon cancer. Abstract [Details]
(2012)Primary Human Xenografts Provide More Accurate Clinical Information Compared to Cell Line Xenografts in Vivo Chemosensitivity Testing.
Sadadcharam, G,McCourt, M,Power, DG,O'Reilly, S,Wang, JH,Redmond, HP,Andrews, EJ (2012) Primary Human Xenografts Provide More Accurate Clinical Information Compared to Cell Line Xenografts in Vivo Chemosensitivity Testing. Abstract [Details]
(2012)MicroRNA Mediated Regulation of Toll-Like Receptor 2 Signalling.
Quinn, EM,Wang, JH,Redmond, HP (2012) MicroRNA Mediated Regulation of Toll-Like Receptor 2 Signalling. Abstract [Details]
(2012)Toll-like receptor-4 signalling confers tumour survival via NOX generated reactive oxygen species in colon cancer.
O'Leary, DP,Bhatt, L,Wang, JH,Cotter, TG,Redmond, HP (2012) Toll-like receptor-4 signalling confers tumour survival via NOX generated reactive oxygen species in colon cancer. Abstract [Details]
(2012)microRNA-146a is upregulated by and negatively regulates the TLR2 signalling pathway.
Quinn, EM,Wang, JH,Redmond, HP (2012) microRNA-146a is upregulated by and negatively regulates the TLR2 signalling pathway. Abstract [Details]
(2012)Unravelling a novel role of myeloid-related proteins 8/14 (Mrp 8/14) in self-tolerance and cross-tolerance to gram-negative and gram-positive bacteria.
Coveney, AP,Wang, JH,Redmond, HP (2012) Unravelling a novel role of myeloid-related proteins 8/14 (Mrp 8/14) in self-tolerance and cross-tolerance to gram-negative and gram-positive bacteria. Abstract [Details]
(2012)microRNA-146a is upregulated by and negatively regulates the TLR2 signalling pathway.
Quinn, EM,Wang, JH,Redmond, HP (2012) microRNA-146a is upregulated by and negatively regulates the TLR2 signalling pathway. Abstract [Details]
(2012)A Phase II Clinical Trial Examining the Peri-Operative Role of the Anti-Neoplastic Agent Taurolidine in Colon Cancer a Interim Analysis.
O'Leary, DP,Neary, PM,McCourt, M,Andrews, EA,O'Riordain, MG,O'Boyle, C,Gough, D,Wang, JH,Redmond, HP (2012) A Phase II Clinical Trial Examining the Peri-Operative Role of the Anti-Neoplastic Agent Taurolidine in Colon Cancer a Interim Analysis. Abstract [Details]
(2013)Bacterial endotoxin enhances metastatic colonisation and liver metastasis in colon cancer cells via Nox derived H2O2.
O'Leary, DP,Wang, JH,Cotter, TG,Redmond, HP (2013) Bacterial endotoxin enhances metastatic colonisation and liver metastasis in colon cancer cells via Nox derived H2O2. Abstract [Details]
(2013)Mice on trial: is xenografts using human tissue a better model of cancer than xenografts formed from cell lines?.
Sadadcharam, G,O'Callaghan, G,McCourt, M,Ryan, C,O'Connor, K,Bennett, B,Power, D,O'Reilly, S,Wang, JH,Redmond, HP,Andrews, EJ (2013) Mice on trial: is xenografts using human tissue a better model of cancer than xenografts formed from cell lines?. Abstract [Details]
(2014)Pre-operative levels of interleukin-6 (IL-6) and vascular endothelial growth factor (VEGF) predict higher post-operative tumour stage in colon cancer patients.
Foley, NM,Hechtl, D,O'Leary, P,Wang, JH,Pfirrman, RW,Redmond, HP (2014) Pre-operative levels of interleukin-6 (IL-6) and vascular endothelial growth factor (VEGF) predict higher post-operative tumour stage in colon cancer patients. Abstract [Details]
(2014)M1 polarised macrophages develop a endotoxin tolerance-like phenomenon in response to bacterial stimulation.
Foley, NM,Wang, JH,Redmond, HP (2014) M1 polarised macrophages develop a endotoxin tolerance-like phenomenon in response to bacterial stimulation. Abstract [Details]
(2014)Lipopolysaccharide (LPS)-Induced Tolerisation Contributes to an Altered Metastatic Potential in Colorectal Cancer Cells.
Hechtl, D,Wang, JH,Redmond, HP (2014) Lipopolysaccharide (LPS)-Induced Tolerisation Contributes to an Altered Metastatic Potential in Colorectal Cancer Cells. Abstract [Details]
(2013)Nox-derived H2O2 mediates colon cancer cell metastatic colonisation and liver metastasis in response to bacterial endotoxin.
O'Leary, DP,Wang, JH,Cotter, TG,Redmond, HP (2013) Nox-derived H2O2 mediates colon cancer cell metastatic colonisation and liver metastasis in response to bacterial endotoxin. Abstract [Details]
(2013)Mice on trial: Is xenografts using human tissue a better model of cancer than xenografts formed from cell lines?.
Sadadcharam, G,McCourt, M,Ryan, C,O'Connor, K,Bennett, B,Power, DG,O'Reilly, S,Wang, JH,Redmond, HP,Andrews, EJ (2013) Mice on trial: Is xenografts using human tissue a better model of cancer than xenografts formed from cell lines?. Abstract [Details]
(2005)High-motility group box protein 1 is a late mediator of the local and systemic effects of acute pancreatitis.
O'Callaghan, A,Wang, JH,Redmond, HP (2005) High-motility group box protein 1 is a late mediator of the local and systemic effects of acute pancreatitis. Abstract [Details]
(2013)Macrophage Polarisation.
Foley, N,Wang, JH,Redmond, HP (2013) Macrophage Polarisation. Abstract [Details]
(2014)Diminished P38 Signalling in M1-Polarised Macrophages in Response to Bacterial Stimulation.
Foley, N,Wang, JH,Redmond, HP (2014) Diminished P38 Signalling in M1-Polarised Macrophages in Response to Bacterial Stimulation. Abstract [Details]
(2013)Mice on trial: Are xenografts using human tissue a better model of cancer than xenografts formed from cell lines?.
Sadadcharam, G,McCourt, M,Ryan, C,O'Connor, K,Bennett, MW,Power, DG,O'Reilly, S,Wang, JH,Redmond, HP,Andrews, EJ (2013) Mice on trial: Are xenografts using human tissue a better model of cancer than xenografts formed from cell lines?. Abstract [Details]

Book Reviews

 YearPublication
(2006)Cellular reprogramming by gram-positive bacterial components: a review.
Buckley, JM,Wang, JH,Redmond, HP (2006) Cellular reprogramming by gram-positive bacterial components: a review. Book Reviews [DOI] [Details]
(2006)The emerging role of toll-like receptor pathways in surgical diseases.
Romics, L,Szabo, G,Coffey, JC,Wang, JH,Redmond, HP (2006) The emerging role of toll-like receptor pathways in surgical diseases. Book Reviews [Details]
(2006)Exploitation of the Toll-like receptor system in cancer: a doubled-edged sword?.
Killeen, SD,Wang, JH,Andrews, EJ,Redmond, HP (2006) Exploitation of the Toll-like receptor system in cancer: a doubled-edged sword?. Book Reviews [DOI] [Details]
(2012)The emerging role of microRNA in regulation of endotoxin tolerance.
Quinn, EM,Wang, JH,Redmond, HP (2012) The emerging role of microRNA in regulation of endotoxin tolerance. Book Reviews [DOI] [Details]

Reviews

 YearPublication
(2013)Links between Toll-like receptor 4 and breast cancer.
Ahmed, A,Redmond, HP,Wang, JH (2013) Links between Toll-like receptor 4 and breast cancer. Reviews [DOI] [Details]

Other

 YearPublication
(1998)Nitric oxide mediates hepatocyte injury.
Wang, JH,Redmond, HP,Wu, QD,Bouchier-Hayes, D (1998) Nitric oxide mediates hepatocyte injury. Other [Details]
(1999)Dopamine induces neutrophil apoptosis through a dopamine D-1 receptor-independent mechanism.
Sookhai, S,Wang, JH,McCourt, M,O'Connell, D,Redmond, HP (1999) Dopamine induces neutrophil apoptosis through a dopamine D-1 receptor-independent mechanism. Other [Details]
(1999)Neutrophil heat shock protein expression and activation correlate with increased apoptosis following transmigration through the endothelial barrier.
Hennigan, SN,Wang, JH,Redmond, HP,Bouchier-Hayes, D (1999) Neutrophil heat shock protein expression and activation correlate with increased apoptosis following transmigration through the endothelial barrier. Other [Details]
(1999)Proinflammatory mediators stimulate neutrophil-directed angiogenesis.
McCourt, M,Wang, JH,Sookhai, S,Redmond, HP (1999) Proinflammatory mediators stimulate neutrophil-directed angiogenesis. Other [Details]
(2000)Dopamine attenuates the chemoattractant effect of interleukin-8: A novel role in the systemic inflammatory response syndrome.
Sookhai, S,Wang, JH,Winter, D,Power, C,Kirwan, W,Redmond, HP (2000) Dopamine attenuates the chemoattractant effect of interleukin-8: A novel role in the systemic inflammatory response syndrome. Other [Details]
(2000)Neutrophil-induced transmigration of tumour cells treated with tumour-conditioned medium is facilitated by granulocyte-macrophage colony-stimulating factor.
Wu, QD,Wang, JH,Bouchier-Hayes, D,Redmond, HP (2000) Neutrophil-induced transmigration of tumour cells treated with tumour-conditioned medium is facilitated by granulocyte-macrophage colony-stimulating factor. Other [Details]
(2000)Untitled.
Street, JT,Wang, JH,Power, CJ,Redmond, HP (2000) Untitled. Other [Details]
(2001)Upregulation of Fas-Fas-L (CD95/CD95L)-mediated epithelial apoptosis - A putative role in pouchitis?.
Coffey, JC,Bennett, MW,Wang, JH,O'Connell, J,Neary, P,Shanahan, F,Redmond, HP,Kirwan, WO (2001) Upregulation of Fas-Fas-L (CD95/CD95L)-mediated epithelial apoptosis - A putative role in pouchitis?. Other [DOI] [Details]
(2001)The angiogenic response to skeletal injury is preserved in the elderly.
Street, JT,Wang, JH,Wu, QD,Wakai, A,McGuinness, A,Redmond, HP (2001) The angiogenic response to skeletal injury is preserved in the elderly. Other [Details]
(2001)Inosine attenuates tourniquet-induced skeletal muscle reperfusion injury.
Wakai, A,Winter, DC,Street, JT,O'Sullivan, RG,Wang, JH,Redmond, HP (2001) Inosine attenuates tourniquet-induced skeletal muscle reperfusion injury. Other [DOI] [Details]
(2001)Sodium hyaluronate enhances colorectal tumour cell metastatic potential in vitro and in vivo (Br J Surg 2001; 88: 246-50) - Reply.
Tan, B,Wang, JH,Wu, QD,Kirwan, WO,Redmond, HP (2001) Sodium hyaluronate enhances colorectal tumour cell metastatic potential in vitro and in vivo (Br J Surg 2001; 88: 246-50) - Reply. Other [Details]
(2001)Is immunohistochemical analysis an appropriate diagnostic technique for bone marrow micrometastases?.
Redmond, KC,Wang, JH,Austin, KK,Relihan, N,McGreal, G,Kirwan, WO,Richardson, D,Kelly, J,Redmond, HP (2001) Is immunohistochemical analysis an appropriate diagnostic technique for bone marrow micrometastases?. Other [Details]
(2002)Role of the neutrophil in the development of systemic inflammatory response syndrome and sepsis following abdominal aortic surgery (Br J Surg 2001; 88 : 1583-9) - Letter 2.
O'Sullivan, AW,Wang, JH,Redmond, HP (2002) Role of the neutrophil in the development of systemic inflammatory response syndrome and sepsis following abdominal aortic surgery (Br J Surg 2001; 88 : 1583-9) - Letter 2. Other [Details]
(2002)Hypoxia upregulates Bcl-2 expression and suppresses interferon-gamma induced antiangiogenic activity in human tumor derived endothelial cells.
Wang, JH,Wu, QD,Bouchier-Hayes, D,Redmond, HP (2002) Hypoxia upregulates Bcl-2 expression and suppresses interferon-gamma induced antiangiogenic activity in human tumor derived endothelial cells. Other [DOI] [Details]
(2003)Hypertonic saline infusion for pulmonary injury due to ischemia-reperfusion.
Shields, CJ,Winter, DC,Manning, BJ,Wang, JH,Kirwan, WO,Redmond, HP (2003) Hypertonic saline infusion for pulmonary injury due to ischemia-reperfusion. Other [Details]
(2003)Induction of angiogenic cytokine expression in cultured RPE by ingestion of oxidized photoreceptor outer segments.
Higgins, GT,Wang, JH,Dockery, P,Cleary, PE,Redmond, HP (2003) Induction of angiogenic cytokine expression in cultured RPE by ingestion of oxidized photoreceptor outer segments. Other [DOI] [Details]
(2003)Gene expression profiling in biliary atresia.
Smith, MJF,Coffey, JC,Wang, JH,Cotter, TG,Redmond, HP (2003) Gene expression profiling in biliary atresia. Other [Details]
(2005)Surgically induced accelerated local and distant tumor growth is significantly attenuated by selective COX-2 inhibition.
Qadri, SSA,Wang, JH,Coffey, JC,Alam, M,O'Donnell, A,Aherne, T,Redmond, HP (2005) Surgically induced accelerated local and distant tumor growth is significantly attenuated by selective COX-2 inhibition. Other [DOI] [Details]
(2005)Can surgery for cancer accelerate the progression of secondary tumors within residual minimal disease at both local and systemic levels?.
Qadri, SSA,Wang, JH,Coffey, JC,Alam, M,O'Donnell, A,Aherne, T,Redmond, HP (2005) Can surgery for cancer accelerate the progression of secondary tumors within residual minimal disease at both local and systemic levels?. Other [DOI] [Details]
(2006)Activated protein C attenuates acute ischaemia reperfusion injury in skeletal muscle (vol 23, pg 1454, 2005).
Dillon, JP,Laing, AJ,Cahill, RA,O'Brien, GC,Street, JT,Wang, JH,Mc Guinness, A,Redmond, HP (2006) Activated protein C attenuates acute ischaemia reperfusion injury in skeletal muscle (vol 23, pg 1454, 2005). Other [DOI] [Details]
(2007)Inhibition of Phosphoinositide 3-Kinase Negatively Regulates Tlr2-And Tlr4-Mediated Proinflammatory Response to Blp and Lps Respectively, But Not Gram-Positive or Gram-Negative Bacteria.
McSwiney, EA, Wang, JH, Redmond, HP; (2007) Inhibition of Phosphoinositide 3-Kinase Negatively Regulates Tlr2-And Tlr4-Mediated Proinflammatory Response to Blp and Lps Respectively, But Not Gram-Positive or Gram-Negative Bacteria. Other [Details]
(2007)Overexpression of Irak-1, But Not Tlr2, Partly Reverses Bacterial Lipoprotein-Induced Tolerance.
Li Li, CH, Wang, JH, Redmond, HP; (2007) Overexpression of Irak-1, But Not Tlr2, Partly Reverses Bacterial Lipoprotein-Induced Tolerance. Other [Details]
(2009)Clinical Implications of the Mechanisms Driving Breast Cancer Local Recurrence.
Smith, M,Wang, JH,Cotter, T,Redmond, H (2009) Clinical Implications of the Mechanisms Driving Breast Cancer Local Recurrence. Other [DOI] [Details]
(2009)Clinical Implications of The Mechanisms Driving Breast Cancer Local Recurrence.
Smith, M, Wang, JH, Cotter, T, Redmond, H; (2009) Clinical Implications of The Mechanisms Driving Breast Cancer Local Recurrence. Other [DOI] [Details]

Professional Activities

Employment

 EmployerPositionFrom / To
Surgery / Surgical Research Laboratory, UCC College Lecturer/
RCSI Lecturer in Surgical Science01-JAN-97 / 01-JAN-98
RCSI Senior Research Fellow01-JAN-95 / 01-JAN-97

Education

 YearInstitutionQualificationSubject
1977Soochow University MB BCH BAO MEDICAL DOCTORMedicine
1982Third Medical University MDMedicine
1988Third Medical University PHDMedicine

Journal Activities

 JournalRoleTo / From
J Interferon Cytokine Res Referee-
Critical Care Medicine Referee-
Plos One Referee-
British Journal Of Surgery Referee-
Int Immunopharmacol Referee-
Ann Surg Referee-
Sci Rep-Uk Editor-
Chin J Traumatol Editor-
J Leukoc Biol Referee-
Burns Referee-

Research Information

Internal Collaborators

 NameInstituteCountry
Professor Thomas Cotter Biochemistry, UCC

External Collaborators

 NameOrganisation/ InstitutionCountry
Professor Jing Hua Liu Southern Medical UniversityCHINA
Professor Jian Wang Soochow UniversityCHINA
Professor Fu-Tong Liu University of California – DavisU.S.A.
Professor Min Zhao University of California – DavisU.S.A.
Professor Jie Fan University of Pittsburgh, Pittsburgh, PAU.S.A.

Contact details

Search profiles by name

Search profiles by topic

School of Biological, Earth and Environmental Sciences

An Scoil Eolaíochtaí Bitheolaíocha, Domhaneolaíocha agus Comhshaoil

University College Cork, Distillery Fields, North Mall, Cork, Ireland T23 N73K

Top