Research Profile

Patrick Forde

Biography

Dr Patrick Forde BSc, PhD.
Principal Investigator at the Cancer Research at UCC (Former Cork Cancer Research Centre) where I head a research focused team developing physical and immune-based therapies. 








Research Interests

- immunogenic control of cancer
- novel cancer therapies
- Physical therapies
- Gene and drug delivery

Research Grants

 ProjectFunding
Body
Start DateEnd DateAward
Harnessing the immune system to target primary and secondary pancreatic cancerOther: Not Listed30-NOV-1401-NOV-17€240,000.56
lung electrochemotherapy and immunotherapyMedical Research Council16-JAN-1915-JAN-22€158,293.00
Harnessing the immune system to target primary and secondary pancreatic cancer.Foreign Research Institute02-APR-1522-AUG-19€227,036.00
Making Therapy more effective for Pancreatic Cancer using ElectrochemotherapyIrish Funded Research01-JUN-1831-MAY-20€78,713.00
Novartis C&CRA 2018/027 (via CUF): Retrospective Analysis Examining the Effect of Macrophages & Gene Expression on Patient Responses to Treatment for MelanomaFoundation Funded Research09-JAN-1830-APR-19€16,000.00
Cancers of Poor Prognosis: Immunogenic PathwaysIrish Funded Research01-MAY-1830-APR-20€78,540.00
Osteosarcoma- Combination of Electroporation of Metabolic Modulcators with Low Dose Chemotherapy.Irish Funded Research01-DEC-1730-NOV-18€17,770.00

Publications

Book Chapters

 YearPublication
(2018)'Biomaterial-Mediated Drug Delivery in Primary and Metastatic Cancers of the Bone'
Patrick F. Forde and Katie B. Ryan (2018) 'Biomaterial-Mediated Drug Delivery in Primary and Metastatic Cancers of the Bone' In: Li, Bingyun, Webster, Thomas (Eds.) (eds). Orthopedic Biomaterials. USA: Springer. [Details]
(2011)'Minimally Invasive Intraluminal Tumor Ablation'
Patrick F. Forde, Michael G. Bourke, Slawomir Salwa, Gerald C. O’Sullivan, Declan M. Soden: (2011) 'Minimally Invasive Intraluminal Tumor Ablation' In: Clinical aspects of Electroporation. New York: Springer-Verlag New York. [Details]
(2011)'Clinical Application of Electrochemotherapy – An Adjunct to Surgery Clinical Aspects of Eletroporation'
Mira Sadadcharam, Patrick Forde, Declan M Soden, Gerald C O’ Sullivan (2011) 'Clinical Application of Electrochemotherapy – An Adjunct to Surgery Clinical Aspects of Eletroporation' In: Electroporation in Laboratory and Clinical Investigations. US: novapublishers. [Details]
(2010)'Combined Electrical Field and Ultrasound'
Patrick F Forde, Ciara Twomey, Gerald C O'Sullivan, Declan M Soden (2010) 'Combined Electrical Field and Ultrasound' In: Advanced Electroporation Techniques in Biology and Medicine. US: CRC Press. [Details]

Peer Reviewed Journals

 YearPublication
(2018)'ICOS activation in combination with electrochemotherapy generates effective anti-cancer immunological responses in murine models of primary, secondary and metastatic disease'
Liam F. Tremble, Morgan A. O'Brien, Patrick F.Forde, Declan M.Soden (2018) 'ICOS activation in combination with electrochemotherapy generates effective anti-cancer immunological responses in murine models of primary, secondary and metastatic disease'. Cancer Letters, 420 :109-115 [DOI] [Details]
(2018)'Electrochemotherapy with cisplatin increases survival and induces immunogenic responses in murine models of lung cancer and colorectal cancer'
Tremble LF;O'Brien MA;Forde PF; (2018) 'Electrochemotherapy with cisplatin increases survival and induces immunogenic responses in murine models of lung cancer and colorectal cancer'. Cancer Letters, [DOI] [Details]
(2018)'Combination of electroporation delivered metabolic modulators with low-dose chemotherapy in Osteosarcoma'
KS. Gill, P Fernandes, B Bird, Declan M. Soden, Patrick F. Forde (2018) 'Combination of electroporation delivered metabolic modulators with low-dose chemotherapy in Osteosarcoma'. Oncotarget, 59 (9):31473-31489 [DOI] [Details]
(2018)'Expressional changes in stemness markers post electrochemotherapy in pancreatic cancer cells'
Ali, Shahzad; Gill, Kheshwant S.; Saglio. Giuseppe; Cilloni, Daniela; Soden, Declan M.; Forde, Patrick F. (2018) 'Expressional changes in stemness markers post electrochemotherapy in pancreatic cancer cells'. Bioelectrochemistry,   [DOI] [CORA Link] [Details]
(2016)'Preclinical evaluation of an endoscopic electroporation system'
Patrick F Forde, Mira Sadadcharam, Michael G Bourke, Thomas A Conway, Shane R Gurein, Marcel de Kruijf, Gerald O' Sullivan, Joseph Impellizeri, Anthony James P Clover, Declan M Soden (2016) 'Preclinical evaluation of an endoscopic electroporation system'. Endoscopy, [Details]
(2016)'Glycolysis inhibition as a cancer treatment and its role in an anti-tumour immune response'
Kheswant S Gill, Philana Fernades, Tracey R O' Donovan, Sharon L Mckenna, Kishore K Daddakula, Derek G Power, Declan M Soden, Patrick F Forde (2016) 'Glycolysis inhibition as a cancer treatment and its role in an anti-tumour immune response'. BBA Biochimica et Biophysica Acta, [Details]
(2016)'Antitumour responses induced by a cell-based Reovirus vaccine in murine lung and melanoma models'
Ciorsdan Campion, Declan M Soden, Patrick F Forde (2016) 'Antitumour responses induced by a cell-based Reovirus vaccine in murine lung and melanoma models'. BMC Cancer, 16 (1) [Details]
(2015)'Successful Management of an Occult Cardiac Tamponade with Prompt Surgical Intervention and a Novel, Defined Pericardial Irrigation Protocol'
Saleem Janheer, Rebecca E Gardiner, Patrcik Fode, John Hinchion (2015) 'Successful Management of an Occult Cardiac Tamponade with Prompt Surgical Intervention and a Novel, Defined Pericardial Irrigation Protocol'. Journal Of Thoracic And Cardiovascular Surgery, [Details]
(2015)'Low immunogenicity in non-small cell lung cancer; do new developments and novel treatments have a role?'
Rebecca E Gardiner, Saleem Jahangeer, Patrick F Forde, Arlizan B Ariffin, Brian Bird, Declan M Soden, John Hinchion (2015) 'Low immunogenicity in non-small cell lung cancer; do new developments and novel treatments have a role?'. SpringerPlus, 34 (1):129-144 [Details]
(2014)'Enhancement of electroporation facilitated immunogene therapy via T-reg depletion'
Patrick F Forde, Mira Sadadcharam, Tracey R O’Donovan, Lindsay J Hall, Marcel de Kruijf, William L Byrne, Gerald C O’Sullivan, Declan M. Soden. (2014) 'Enhancement of electroporation facilitated immunogene therapy via T-reg depletion'. Cancer Gene Therapy, [Details]
(2014)'Development and characterization of an enhanced nonviral expression vector for electroporation cancer treatment'
Patrick F. Forde, Lindsay J. Hall, Mira Sadadcharam, Marcle de Kruijf, Gerald C. O’Sullivan, Declan M. Soden (2014) 'Development and characterization of an enhanced nonviral expression vector for electroporation cancer treatment'. Molecular Therapy, [Details]
(2014)'Releasing Pressure in Tumors: What Do We Know So Far and Where Do We Go from Here? A Review'
Arlizan B Ariffin, Patrick F Forde, Saleem Jahangeer, Declan M Soden, John Hinchion (2014) 'Releasing Pressure in Tumors: What Do We Know So Far and Where Do We Go from Here? A Review'. Cancer Research, [Details]
(2014)'Non-viral immune electrogene therapy induces potent antitumour responses and has a curative effect in murine colon adenocarcinoma and melanoma cancer models'
Patrick F Forde, Lindsay J Hall, Marcel de Kruijf, M G Bourke, Timothy Doddy, M Sadadcharam, Declan M. Soden. (2014) 'Non-viral immune electrogene therapy induces potent antitumour responses and has a curative effect in murine colon adenocarcinoma and melanoma cancer models'. Cancer Gene Therapy, [Details]
(2014)'Tumour Ablative Therapies: Opportunities for Maximising Immune Engagement and Activation'
Morgan A. O’Brien, Derek G. Power, A. James P. Clover, Brian Bird, Declan M. Soden, Patrick F. Forde. (2014) 'Tumour Ablative Therapies: Opportunities for Maximising Immune Engagement and Activation'. BBA Biochimica et Biophysica Acta, [Details]
(2013)'Electrochemotherapy for the treatment of ocular basal cell carcinoma; a novel adjunct in the disease management'
S P Salwa, M G Bourke, P F Forde, M O'Shaughnessy, S T O'Sullivan, E J Kelly, D M Soden, A J P Clover (2013) 'Electrochemotherapy for the treatment of ocular basal cell carcinoma; a novel adjunct in the disease management'. British Journal of Plastic Surgery, [Details]
(2011)'The emerging role of viruses in the treatment of solid tumours'
Bourke, M. G.,Salwa, S.,Harrington, K. J.,Kucharczyk, M. J.,Forde, P. F.,de Kruijf, M.,Soden, D.,Tangney, M.,Collins, J. K.,O'Sullivan, G. C.; (2011) 'The emerging role of viruses in the treatment of solid tumours'. Cancer Treat Rev,   [Details]
(2011)'The emerging role of viruses in the treatment of solid tumours.. Cancer Treatment Reviews'
M G Bourke, S Salwa, K J Harrington, M J Kucharczyk, P F Forde, M de Kruijf, D Soden, M Tangney, J K Collins, G C O'Sullivan (2011) 'The emerging role of viruses in the treatment of solid tumours.. Cancer Treatment Reviews'. Cancer Treatment Reviews, [Details]

Abstract

 YearPublication
(2013)Pre-clinical validationof electrochemotherapy (ECT) in the treatment of lung tumours.
Jahangeer, S,Forde, P,Soden, D,Hinchion, J (2013) Pre-clinical validationof electrochemotherapy (ECT) in the treatment of lung tumours. Abstract [Details]
(2013)PRE-CLINICAL VALIDATION OF ELECTROCHEMOTHERAPY (ECT) IN THE TREATMENT OF LUNG TUMOURS.
Jahangeer, S;Forde, P;Soden, D;Hinchion, J (2013) PRE-CLINICAL VALIDATION OF ELECTROCHEMOTHERAPY (ECT) IN THE TREATMENT OF LUNG TUMOURS. PHILADELPHIA: Abstract [Details]
(2012)Reconditioning the Tumour Microenvironment with Immunogene Therapy Suppresses Tumour Development and Progression.
Bourke, MG;Forde, P;de Kruijf, M;O'Donovan, T;Casey, G;Soden, DM;O'Sullivan, GC (2012) Reconditioning the Tumour Microenvironment with Immunogene Therapy Suppresses Tumour Development and Progression. LONDON: Abstract [Details]
(2012)Lentiviral-mediated cell-specific RNA interference in regulatory T cells.
Byrne, WL;Forde, P;O'Sullivan, G (2012) Lentiviral-mediated cell-specific RNA interference in regulatory T cells. PHILADELPHIA: Abstract [DOI] [Details]
(2010)DEVELOPMENT OF AN ENDOSCOPICALLY DELIVERED ABLATIVE TREATMENT FOR GASTROINTESTINAL TUMOURS.
Bourke, MG;Salwa, S;Sadadcharam, M;Forde, P;O'Sullivan, GC;Soden, D (2010) DEVELOPMENT OF AN ENDOSCOPICALLY DELIVERED ABLATIVE TREATMENT FOR GASTROINTESTINAL TUMOURS. LONDON: Abstract [Details]
(2012)Reconditioning the Tumour Microenvironment with Immunogene Therapy Suppresses Tumour Development and Progression.
Bourke, MG,Forde, P,de Kruijf, M,O'Donovan, T,Casey, G,Soden, DM,O'Sullivan, GC (2012) Reconditioning the Tumour Microenvironment with Immunogene Therapy Suppresses Tumour Development and Progression. Abstract [Details]
(2010)DEVELOPMENT OF AN ENDOSCOPICALLY DELIVERED ABLATIVE TREATMENT FOR GASTROINTESTINAL TUMOURS.
Bourke, MG,Salwa, S,Sadadcharam, M,Forde, P,O'Sullivan, GC,Soden, D (2010) DEVELOPMENT OF AN ENDOSCOPICALLY DELIVERED ABLATIVE TREATMENT FOR GASTROINTESTINAL TUMOURS. Abstract [Details]

Reviews

 YearPublication
(2016)Electroporation in veterinary oncology.
Impellizeri, J;Aurisicchio, L;Forde, P;Soden, DM (2016) Electroporation in veterinary oncology. OXFORD: Reviews [DOI] [Details]
(2015)Low immunogenicity in non-small cell lung cancer; do new developments and novel treatments have a role?.
Gardiner, RE;Jahangeer, S;Forde, P;Ariffin, AB;Bird, B;Soden, D;Hinchion, J (2015) Low immunogenicity in non-small cell lung cancer; do new developments and novel treatments have a role?. DORDRECHT: Reviews [DOI] [Details]
(2013)Review of current thermal ablation treatment for lung cancer and the potential of electrochemotherapy as a means for treatment of lung tumours.
Jahangeer, S;Forde, P;Soden, D;Hinchion, J (2013) Review of current thermal ablation treatment for lung cancer and the potential of electrochemotherapy as a means for treatment of lung tumours. OXFORD: Reviews [DOI] [Details]

Professional Activities

Honours and Awards

 YearTitleAwarding Body
2014Pancreatic Cancer Research Fund, UK Pancreatic Cancer Research Fund, UK
2014Pfizer Award for Innovation through Teamwork Pfizer Award for Innovation through Teamwork

Other Activities

 Description


Completed Professional Skills for Research Leaders online programme in 2016. Received Certificate Institute of Leadership and Management

Teaching Activities

Recent Postgraduates

 Graduation YearStudent NameInstitutionDegree TypeThesis Title
2015Arlizan B Ariffin University College CorkMDTumour interstitial pressure and its modulation
2016Morgan A O' Brien University College CorkPhDImmunotherapy for the treatment of poor prognosis cancers

Current Postgraduate Students

 StudentDegree Type
Gill Kheshwant Singh Doctoral Degree
Murphy Joseph Doctoral Degree
Tremble Liam Friel Doctoral Degree

Contact details

  • Patrick Forde
    Principal Investigator
  • p.forde@ucc.ie
  • Cancer Research @UCC
    Western Gateway Building
    University College Cork
    Irelan
  • 0214205706

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School of Biological, Earth and Environmental Sciences

An Scoil Eolaíochtaí Bitheolaíocha, Domhaneolaíocha agus Comhshaoil

University College Cork, Distillery Fields, North Mall, Cork, Ireland T23 N73K

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