Understanding small molecule signalling in microbial communities for ecosystem and human health: The foundation of microbial behaviour, whether the expression of virulence, persistence through community formations called biofilms, or the expression of novel biosynthetic gene clusters and natural products, is governed by cell-cell communication. The emergence of technologies that enable us to appreciate and investigate the microbial communities that colonise diverse ecological and clinical niches has led to a new understanding of disease progression. The lungs, previously considered a sterile environment periodically colonised by harmful pathogens, are now known to carry a rich and diverse microbial community. Deciphering the cell-cell communication systems that govern the interactions between these diverse species is key to delivering innovative and effective new therapies for disease management. Interactions between established and emerging pathogens is of particular interest. A major part of this discovery based programme is the development of systems-based approaches and appropriate models in which to study microbial behaviour. This will lead to a better understanding of microbial pathogenesis during infection, in light of the diversity within the polymicrobial communities that exist in these ecological niches.
Overcoming antimicrobial resistance (AMR) through chemico-biological therapeutics: As the age of the global population continues to increase year on year, the challenges in maintaining health and quality of life (QoF) continue to exercise the commercial and academic communities. We are and will continue to live longer, and this brings with it its own challenges. Antibiotic-based therapies are under severe pressure due to the continuing emergence of resistant pathogens, while conventional therapies are limited by their target specificities. Furthermore, off target effects of large biologics has led the search for more specific molecular based therapeutics. My research interests lie in pursuing chemico-biological molecular approaches to identify and develop small bioactive molecules. This then provides the basis with which to underpin innovations in therapeutic developments, new biotechnological developments, and next generation solutions, primarily for the pharmaceutical, cosmetic and medical device industries. Furthermore, these natural products also address the environmentally conscious end-user market need for eco-friendly and safe therapeutics.
Delivering solutions for ecosystem health and sustainable pharmaceutical production: For many years now there has been a significant emphasis on green chemistry approaches to drug development. Already known to be the source of a rich tapestry of bioactive potential, the marine ecosystem has also delivered a distinctive repertoire of enzymes with industrial application. Notable amongst this has been the application of biocatalysts in green chemistry approaches to drug synthesis, offering safer, more sustainable, and importantly enantioselective options for (Bio)Pharma. Our research takes a dual approach to uncovering these novel enzymes, focusing not just on their industrial application, but also investigating the natural role for these unique properties in maintaining ecosystem health in the oceans and marine life. Several first in class enzymes are already in development through molecular modelling and protein engineering. Others are at the stage of early chatracterisation.
Rewiring (Post)Transcriptional regulatory systems for industrial application: Signal perception and transduction through tightly coordinated circuits is integral to the survival and persistence of microbes in diverse ecological niches. The capacity of microbes to adapt to changes in the environment is central to their ability to thrive under adverse circumstances. Signal dependent transcriptional regulators are a key mechanism through which microbes assimilate environmental cues and mediate the appropriate adaptive response. By far the largest class of transcriptional regulator is the LysR-class, which is universally distributed among bacteria, archaea, and even eukaryotic organisms. The number of LysR-Type Transcriptional Regulators (LTTRs) varies among species with one of the largest repertoires encoded in the genome of the nosocomial pathogen Pseudomonas aeruginosa. I am interested in understanding the evolutionary basis for the emergence of this class of transcriptional regulator, and elucidating the hierarchical network that underpins their control of virulence and pathogenesis in nosocomial pathogens.
Biography
Dr F. Jerry Reen did a BSc in Biochemistry at the National University of Ireland Galway (NUIG), subsequently pursuing a PhD in the Molecular GlycoBiotechnology Group at NUIG, being awarded both an Enterprise Ireland Scholarship and an NUI Teaching Fellowship. In Oct 2002, Jerry took up a PostDoctoral position in the lab of Dr. E. Fidelma Boyd in the Department of Microbiology at University College Cork (UCC). During that time he was a visiting scientist at the Sidney Kimmel Cancer Center, San Diego, USA and was awarded an IRCSET Postdoctoral Fellowship to study bacteriophage-host interactions. He subsequently took up a fixed term lecturing position in the School of Microbiology, while also joining the BIOMERIT Research Centre where he developed an interest in small molecule research and host-microbe interactions in chronic disease. In 2011, he won the inaugural Science Foundation Ireland TIDA ‘Dragons Den’ and was hosted in Silicon Valley, San Jose by the Irish Technology Leadership Group. He has since won several awards for his research and has published over 80 peer reviewed scientific papers (h-index 26). Jerry has been a member of faculty in the School of Microbiology at UCC since 2017, where his research interests are in deciphering the communication systems underpinning polymicrobial-host interactions for human and ecosystem health, as well as delivering green sustainable solutions for the (Bio)Pharma industry. His teaching has led to several innovations based on universality, inclusivity, and neurodiversity, with particular focus on the development of student partnered virtual reality simulations as a pedagogical tool enabling access to challenging abstract concepts.Research Interests
Throughout my research career I have developed a strong interdisciplinary background in biochemistry, microbiology, chemistry, and bioinformatics. This experience has resulted in several interdisciplinary collaborations being established with colleagues from other Schools within UCC and further afield, links which I am keen to continue to develop going forward. Deciphering the common signatures that define distantly related organisms provides a unique perspective on the dynamic interactions that govern their co-existence. From a translational perspective, developing a network of compounds that modulate cellular behaviour provides the template for a synthetic diversity approach that is being used to develop antagonistic compounds for drug development.Understanding small molecule signalling in microbial communities for ecosystem and human health: The foundation of microbial behaviour, whether the expression of virulence, persistence through community formations called biofilms, or the expression of novel biosynthetic gene clusters and natural products, is governed by cell-cell communication. The emergence of technologies that enable us to appreciate and investigate the microbial communities that colonise diverse ecological and clinical niches has led to a new understanding of disease progression. The lungs, previously considered a sterile environment periodically colonised by harmful pathogens, are now known to carry a rich and diverse microbial community. Deciphering the cell-cell communication systems that govern the interactions between these diverse species is key to delivering innovative and effective new therapies for disease management. Interactions between established and emerging pathogens is of particular interest. A major part of this discovery based programme is the development of systems-based approaches and appropriate models in which to study microbial behaviour. This will lead to a better understanding of microbial pathogenesis during infection, in light of the diversity within the polymicrobial communities that exist in these ecological niches.
Overcoming antimicrobial resistance (AMR) through chemico-biological therapeutics: As the age of the global population continues to increase year on year, the challenges in maintaining health and quality of life (QoF) continue to exercise the commercial and academic communities. We are and will continue to live longer, and this brings with it its own challenges. Antibiotic-based therapies are under severe pressure due to the continuing emergence of resistant pathogens, while conventional therapies are limited by their target specificities. Furthermore, off target effects of large biologics has led the search for more specific molecular based therapeutics. My research interests lie in pursuing chemico-biological molecular approaches to identify and develop small bioactive molecules. This then provides the basis with which to underpin innovations in therapeutic developments, new biotechnological developments, and next generation solutions, primarily for the pharmaceutical, cosmetic and medical device industries. Furthermore, these natural products also address the environmentally conscious end-user market need for eco-friendly and safe therapeutics.
Delivering solutions for ecosystem health and sustainable pharmaceutical production: For many years now there has been a significant emphasis on green chemistry approaches to drug development. Already known to be the source of a rich tapestry of bioactive potential, the marine ecosystem has also delivered a distinctive repertoire of enzymes with industrial application. Notable amongst this has been the application of biocatalysts in green chemistry approaches to drug synthesis, offering safer, more sustainable, and importantly enantioselective options for (Bio)Pharma. Our research takes a dual approach to uncovering these novel enzymes, focusing not just on their industrial application, but also investigating the natural role for these unique properties in maintaining ecosystem health in the oceans and marine life. Several first in class enzymes are already in development through molecular modelling and protein engineering. Others are at the stage of early chatracterisation.
Rewiring (Post)Transcriptional regulatory systems for industrial application: Signal perception and transduction through tightly coordinated circuits is integral to the survival and persistence of microbes in diverse ecological niches. The capacity of microbes to adapt to changes in the environment is central to their ability to thrive under adverse circumstances. Signal dependent transcriptional regulators are a key mechanism through which microbes assimilate environmental cues and mediate the appropriate adaptive response. By far the largest class of transcriptional regulator is the LysR-class, which is universally distributed among bacteria, archaea, and even eukaryotic organisms. The number of LysR-Type Transcriptional Regulators (LTTRs) varies among species with one of the largest repertoires encoded in the genome of the nosocomial pathogen Pseudomonas aeruginosa. I am interested in understanding the evolutionary basis for the emergence of this class of transcriptional regulator, and elucidating the hierarchical network that underpins their control of virulence and pathogenesis in nosocomial pathogens.
Research Grants
| Project | Funding Body | Start Date | End Date | Award | |
|---|---|---|---|---|---|
| 'BioBloc' enhanced Contact LEns solutioNS (BBCLENS) | Enterprise Ireland | 27-NOV-17 | 26-NOV-18 | €138,525.00 | |
| HEACOVID19 | 01-DEC-21 | 31-OCT-22 | €19,472.00 | ||
| SFI 12/RC/2275_2 SSPC3 Pharm5 - Platform - Bursary - F. Jerry Reen (X) | Science Foundation of Ireland | 01-JUL-22 | 30-JUN-23 | €5,000.00 | |
| Targeted synthesis and biological evaluation of pyrones and related heterocycles as bacteria inhibitors | Irish Research Council | 01-OCT-21 | 30-SEP-25 | €96,000.00 | |
| Evaluating a novel macrolide based early intervention in the clinical management of chronic infections and inflammation in Cystic Fibrosis | Health Research Board | 05-NOV-18 | 05-NOV-21 | €115,000.00 | |
| Bile Acids as a host trigger of Chronic infecting Pathogens in Respiratory Disease | Health Research Board | 01-NOV-19 | 31-OCT-22 | €367,994.00 | |
| HEACOVID19 | 01-APR-21 | 31-JUL-21 | €14,239.00 | ||
| Investigating the Molecular Networks that lead Dominant Respiratory Pathogens to Emerge from within Polymicrobial Communities in Respiratory Disease. | Irish Research Council | 01-SEP-21 | 31-AUG-25 | €110,000.00 | |
| ELEVATE | Higher Education authority | 01-DEC-19 | 31-MAY-21 | €25,000.00 |
Publications
Book Chapters
| Year | Publication | |
|---|---|---|
| (2018) | 'Rapid Electrochemical Detection of Pseudomonas aeruginosa Signaling Molecules by Boron-Doped Diamond Electrode' Buzid, A.,Luong, J. H. T.,Reen, F. J.,O'Gara, F.,Glennon, J. D.,McGlacken, G. P. (2018) 'Rapid Electrochemical Detection of Pseudomonas aeruginosa Signaling Molecules by Boron-Doped Diamond Electrode' In: Methods Mol Biol. Cambridge (UK): Springer. [DOI] [Details] | |
| (2016) | 'Metagenomics as a tool for biodiscovery and enhanced production of marine bioactives' Jerry Reen F.;Dobson A.;O’Gara F. (2016) 'Metagenomics as a tool for biodiscovery and enhanced production of marine bioactives' In: The Marine Microbiome: An Untapped Source of Biodiversity and Biotechnological Potential. [DOI] [Details] | |
| (2005) | 'Vibrio species: Pathogenesis and stress response' Reen F.;Boyd E. (2005) 'Vibrio species: Pathogenesis and stress response' In: Understanding Pathogen Behaviour. [DOI] [Details] | |
| (2017) | 'Mining Microbial Signals for Enhanced Biodiscovery of Secondary Metabolites' Reen, F. J.,Gutierrez-Barranquero, J. A.,O'Gara, F. (2017) 'Mining Microbial Signals for Enhanced Biodiscovery of Secondary Metabolites' In: Methods Mol Biol. Cambridge (UK): Springer. [DOI] [Details] | |
| (2017) | 'Rapid Electrochemical Detection of Pseudomonas aeruginosa Signaling Molecules by Boron-Doped Diamond Electrode' Buzid, A., Luong, J.H.T., Reen, F.J., O’Gara, F., Glennon, J.D. and McGlacken, G.P. (2017) 'Rapid Electrochemical Detection of Pseudomonas aeruginosa Signaling Molecules by Boron-Doped Diamond Electrode' In: Leoni L., and Rampioni, G (eds). Quorum Sensing – Methods and Protocols. U.S.A: Sprinter. [DOI] [Details] | |
| (2016) | 'Metagenomics as a tool for biodiscovery and enhancement of production of bioactives' Reen F.J. and F. O’Gara. (2016) 'Metagenomics as a tool for biodiscovery and enhancement of production of bioactives' In: Stahl, L and Creitou, M.S (eds). The marine microbiome – an untold resource of biodiversity and biotechnological potential. USA: Springer. [DOI] [Details] | |
| (2016) | 'Bile Aspiration; a host factor modulating chronic respiratory infection' Flynn, S., Woods, D., Ní Chróinín, M., Mullane, D., Adams, C., Reen, F.J. & F O’Gara. (2016) 'Bile Aspiration; a host factor modulating chronic respiratory infection' In: Johnston, N. & Toohill, R.J (eds). Bile Acids: Biosynthesis, Metabolic Regulation and Biological Functions. USA: Nova Science Publishers. [Details] |
Peer Reviewed Journals
| Year | Publication | |
|---|---|---|
| (2023) | 'Structural modification of the Pseudomonas aeruginosa alkylquinoline cell-cell communication signal, HHQ, leads to benzofuranoquinolines with anti-virulence behaviour in ESKAPE pathogens' Rossetto V;Moore-Machacek A;Woods DF;Galvão HM;Shanahan RM;Hickey A;O'Leary N;O'Gara F;McGlacken GP;Reen FJ; (2023) 'Structural modification of the Pseudomonas aeruginosa alkylquinoline cell-cell communication signal, HHQ, leads to benzofuranoquinolines with anti-virulence behaviour in ESKAPE pathogens'. Microbiology-SGM, 169 (3) [DOI] [Details] | |
| (2023) | 'Uncovering the Biotechnological Importance of Geotrichum candidum' Kamiliari E., Stanton C., Reen FJ, Ross RP (2023) 'Uncovering the Biotechnological Importance of Geotrichum candidum'. Foods (Basel, Switzerland), 12 (6) [Details] | |
| (2022) | 'N-Alkyl-2-Quinolonopyrones Demonstrate Antimicrobial Activity against ESKAPE Pathogens Including Staphylococcus aureus' Moynihan, E;Mackey, K;Blaskovich, MAT;Reen, J;McGlacken, G (2022) 'N-Alkyl-2-Quinolonopyrones Demonstrate Antimicrobial Activity against ESKAPE Pathogens Including Staphylococcus aureus'. Acs Medicinal Chemistry Letters, 13 :1358-1362 [DOI] [Details] | |
| (2022) | 'Developing Student Co-Designed Immersive Virtual Reality Simulations for Teaching of Challenging Concepts in Molecular and Cellular Biology' Reen FJ., Jump O., McEvoy G., McSharry BP., Morgan J., Murphy D., O'Leary N., O'Mahony B., Scallan M., Walsh C., Supple B., (2022) 'Developing Student Co-Designed Immersive Virtual Reality Simulations for Teaching of Challenging Concepts in Molecular and Cellular Biology'. Fems Microbiology Letters, [DOI] [Details] | |
| (2021) | 'The Use of Virtual Reality in the Teaching of Challenging Concepts in Virology, Cell Culture and Molecular Biology' Reen F. Jerry, Jump Owen, McSharry Brian P., Morgan John, Murphy David, O’Leary Niall, O’Mahony Billy, Scallan Martina, Supple Briony (2021) 'The Use of Virtual Reality in the Teaching of Challenging Concepts in Virology, Cell Culture and Molecular Biology'. 2 (670909) [DOI] [Details] | |
| (2021) | 'Pyrones Identified as LuxR Signal Molecules in Photorhabdus and Their Synthetic Analogues Can Alter Multicellular Phenotypic Behavior of Bacillus atropheaus' Hickey, A;Pardo, LM;Reen, FJ;McGlacken, GP (2021) 'Pyrones Identified as LuxR Signal Molecules in Photorhabdus and Their Synthetic Analogues Can Alter Multicellular Phenotypic Behavior of Bacillus atropheaus'. ACS Omega, 6 :33141-33148 [DOI] [Details] | |
| (2021) | 'Systems Biology and Bile Acid Signalling in Microbiome-Host Interactions in the Cystic Fibrosis Lung' Woods DF;Flynn S;Caparrós-Martín JA;Stick SM;Reen FJ;O'Gara F; (2021) 'Systems Biology and Bile Acid Signalling in Microbiome-Host Interactions in the Cystic Fibrosis Lung'. Antibiotics-Basel, 10 (7) [DOI] [Details] | |
| (2021) | 'Exploring the synthetic potential of a marine transaminase including discrimination at a remote stereocentre' Schwarz, Maria; Murphy, Edel J.; Foley, Aoife M.; Woods, David F.; Castilla, Ignacio Abreu; Reen, F. Jerry; Collins, Stuart G.; O'Gara, Fergal; Maguire, Anita R. (2021) 'Exploring the synthetic potential of a marine transaminase including discrimination at a remote stereocentre'. Organic & Biomolecular Chemistry, 19 (1):188-198 [DOI] [Full Text] [Details] | |
| (2020) | 'A structure-function analysis of interspecies antagonism by the 2-heptyl-4-alkyl-quinolone signal molecule from Pseudomonas aeruginosa' Ramos A.F.;Woods D.F.;Shanahan R.;Cano R.;McGlacken G.P.;Serra C.;O'Gara F.;Reen F.J. (2020) 'A structure-function analysis of interspecies antagonism by the 2-heptyl-4-alkyl-quinolone signal molecule from Pseudomonas aeruginosa'. Microbiology-SGM, 166 (2):169-179 [DOI] [Details] | |
| (2020) | 'Bile Acid Signal Molecules Associate Temporally with Respiratory Inflammation and Microbiome Signatures in Clinically Stable Cystic Fibrosis Patients' Flynn, S;Reen, FJ;Caparros-Martin, JA;Woods, DF;Peplies, J;Ranganathan, SC;Stick, SM;O'Gara, F (2020) 'Bile Acid Signal Molecules Associate Temporally with Respiratory Inflammation and Microbiome Signatures in Clinically Stable Cystic Fibrosis Patients'. Microorganisms, 8 [DOI] [Details] | |
| (2020) | 'The detection of bile acids in the lungs of paediatric cystic fibrosis patients is associated with altered inflammatory patterns' Caparrós-Martín J.A.;Flynn S.;Reen F.J.;Woods D.F.;Agudelo-Romero P.;Ranganathan S.C.;Stick S.M.;O'Gara F. (2020) 'The detection of bile acids in the lungs of paediatric cystic fibrosis patients is associated with altered inflammatory patterns'. Diagnostics, 10 (5) [DOI] [Details] | |
| (2020) | 'Draft Genome Sequences of Three Pseudomonas fluorescens Strains Isolated from Marine Sponges Harvested off the West Coast of Ireland' Gutierrez-Barranquero, JA;Parages, ML;Dobson, ADW;Reen, FJ;O'Gara, F (2020) 'Draft Genome Sequences of Three Pseudomonas fluorescens Strains Isolated from Marine Sponges Harvested off the West Coast of Ireland'. Microbiology Resource Announcements, 9 [DOI] [Details] | |
| (2019) | 'Identification of an Esterase Isolated Using Metagenomic Technology which Displays an Unusual Substrate Scope and its Characterisation as an Enantioselective Biocatalyst' Gavin, Declan P.; Murphy, Edel J.; Foley, Aoife M.; Abreu Castilla, Ignacio; Reen, F. Jerry; Woods, David F.; Collins, Stuart G.; O'Gara, Fergal; Maguire, Anita R. (2019) 'Identification of an Esterase Isolated Using Metagenomic Technology which Displays an Unusual Substrate Scope and its Characterisation as an Enantioselective Biocatalyst'. Advanced Synthesis & Catalysis, 0 (0) [DOI] [Full Text] [Details] | |
| (2019) | 'Quorum Sensing Signaling Alters Virulence Potential and Population Dynamics in Complex Microbiome-Host Interactomes' Reen, FJ;Gutierrez-Barranquero, JA;McCarthy, RR;Woods, DF;Scarciglia, S;Adams, C;Nielsen, KF;Gram, L;O'Gara, F (2019) 'Quorum Sensing Signaling Alters Virulence Potential and Population Dynamics in Complex Microbiome-Host Interactomes'. Frontiers In Microbiology, 10 [DOI] [Details] | |
| (2019) | 'Genome mining and characterisation of a novel transaminase with remote stereoselectivity' Gavin, Declan P.; Reen, F. Jerry; Rocha-Martin, J.; Abreu-Castilla, I.;Woods, David F.;Foley, Aoife M.;Sanchez-Murcia, P. A.;Schwarz, Maria;O'Neill, P.;Maguire, Anita R.; O'Gara, Fergal (2019) 'Genome mining and characterisation of a novel transaminase with remote stereoselectivity'. Scientific Reports, 9 [DOI] [Full Text] [Details] | |
| (2019) | 'Exposure to Bile Leads to the Emergence of Adaptive Signaling Variants in the Opportunistic Pathogen Pseudomonas aeruginosa' Flynn, S;Reen, FJ;O'Gara, F (2019) 'Exposure to Bile Leads to the Emergence of Adaptive Signaling Variants in the Opportunistic Pathogen Pseudomonas aeruginosa'. Frontiers In Microbiology, 10 [DOI] [Details] | |
| (2018) | 'Analogues of Pseudomonas aeruginosa signalling molecules to tackle infections' Ó Muimhneacháin E, Reen F.J., O'Gara F, McGlacken G.P. (2018) 'Analogues of Pseudomonas aeruginosa signalling molecules to tackle infections'. Organic and Biomolecular Chemistry, 16 (2):169-179 [DOI] [Details] | |
| (2018) | 'Harnessing Marine Biocatalytic Reservoirs for Green Chemistry Applications through Metagenomic Technologies' Abreu Castilla, I., Woods, D.F., Reen, F.J. and O’Gara, F. (2018) 'Harnessing Marine Biocatalytic Reservoirs for Green Chemistry Applications through Metagenomic Technologies'. Marine Drugs, [DOI] [Details] | |
| (2018) | 'Synthesis of Benzofuroquinolines via Phosphine-Free Direct Arylation of 4-Phenoxyquinolines in Air' Shanahan, R.M., Hickey, A., Reen, F.J., O'Gara, F. and McGlacken, G.P. (2018) 'Synthesis of Benzofuroquinolines via Phosphine-Free Direct Arylation of 4-Phenoxyquinolines in Air'. European Journal of Organic Chemistry, [DOI] [Details] | |
| (2018) | 'The expanding horizon of alkyl quinolone signalling and communication in polycellular interactomes' Reen, F. Jerry; McGlacken, Gerard P.; O’Gara, Fergal (2018) 'The expanding horizon of alkyl quinolone signalling and communication in polycellular interactomes'. Fems Microbiology Letters, [DOI] [Full Text] [Details] | |
| (2018) | 'Rapid electrochemical detection of pseudomonas aeruginosa signaling molecules by boron-doped diamond electrode' Buzid A.;Luong J.;Reen F.;O’Gara F.;Glennon J.;McGlacken G. (2018) 'Rapid electrochemical detection of pseudomonas aeruginosa signaling molecules by boron-doped diamond electrode'. Live Cell Imaging: Methods And Protocols, 1673 :107-116 [DOI] [Details] | |
| (2017) | 'Statin therapy causes gut dysbiosis in mice through a PXR-dependent mechanism' Caparros-Martin, J. A.,Lareu, R. R.,Ramsay, J. P.,Peplies, J.,Reen, F. J.,Headlam, H. A.,Ward, N. C.,Croft, K. D.,Newsholme, P.,Hughes, J. D.,O'Gara, F. (2017) 'Statin therapy causes gut dysbiosis in mice through a PXR-dependent mechanism'. Microbiome, 5 (1) [DOI] [Details] | |
| (2017) | 'The requirements at the C-3 position of alkylquinolones for signalling in Pseudomonas aeruginosa' Shanahan, Rachel; Reen, F. Jerry; Cano, Rafael; O'Gara, Fergal; McGlacken, Gerard P. (2017) 'The requirements at the C-3 position of alkylquinolones for signalling in Pseudomonas aeruginosa'. Organic & Biomolecular Chemistry, 15 :306-310 [DOI] [Full Text] [Details] | |
| (2017) | 'Disruption of AHL specific signalling and virulence in clinical pathogens by marine sponge bacteria' Gutiérrez-Barranquero, J.A., Reen, F.J., McCarthy, R., Dobson, A.D.W. and O’Gara, F. (2017) 'Disruption of AHL specific signalling and virulence in clinical pathogens by marine sponge bacteria'. Microbial Biotechnology, 10.1111/1751-7915.12867 [Details] | |
| (2017) | 'Disruption of AHL specific signalling and virulence in clinical pathogens by marine sponge bacteria. Microbial Biotechnology' Gutiérrez-Barranquero, J.A., Reen, F.J., McCarthy, R., Dobson, A.D.W. and O’Gara, F. (2017) 'Disruption of AHL specific signalling and virulence in clinical pathogens by marine sponge bacteria. Microbial Biotechnology'. Microbial Biotechnology, doi: 10.1111/1751-7915.12867 [Details] | |
| (2017) | 'Mining microbial signals for enhanced biodiscovery of secondary metabolites' Reen F.;Gutiérrez-Barranquero J.;O’Gara F. (2017) 'Mining microbial signals for enhanced biodiscovery of secondary metabolites'. Live Cell Imaging: Methods And Protocols, 1539 :287-300 [DOI] [Details] | |
| (2017) | 'Rethinking the bile acid/gut microbiome axis in cancer' Phelan, J.P., Reen, F.J., Caparros-Martin, J.A., O’Connor, R., and O’Gara, F. (2017) 'Rethinking the bile acid/gut microbiome axis in cancer'. Oncotarget, 8 (70):115736-115747 [DOI] [Details] | |
| (2016) | 'Integrated (Meta) Genomic and Synthetic Biology Approaches to Develop New Biocatalysts' Parages, María L.; Gutiérrez-Barranquero, José A.; Reen, F. Jerry; Dobson, Alan D.W.; O’Gara, Fergal (2016) 'Integrated (Meta) Genomic and Synthetic Biology Approaches to Develop New Biocatalysts'. Marine Drugs, 14 (3) [DOI] [Full Text] [Details] | |
| (2016) | 'Synthesis and electrochemical detection of a thiazolyl-indole natural product isolated from the nosocomial pathogen Pseudomonas aeruginosa' Buzid, Alyah; Muimhneacháin, Eoin Ó; Reen, F. Jerry; Hayes, Phyllis E.; Pardo, Leticia M.; Shang, Fengjun; O’Gara, Fergal; Sperry, Jonathan; Luong, John H. T.; Glennon, Jeremy D.; McGlacken, Gerard P. (2016) 'Synthesis and electrochemical detection of a thiazolyl-indole natural product isolated from the nosocomial pathogen Pseudomonas aeruginosa'. Analytical and Bioanalytical Chemistry, 408 (23):6361-6367 [DOI] [Full Text] [Details] | |
| (2017) | 'Analogues of Pseudomonas aeruginosa signalling molecules to tackle infections' O. Muimhneachain E,Reen, F. J.,O'Gara, F.,McGlacken, G. P. (2017) 'Analogues of Pseudomonas aeruginosa signalling molecules to tackle infections'. Org Biomol Chem, [DOI] [Details] | |
| (2017) | 'Direct and Rapid Electrochemical Detection of Pseudomonas aeruginosa Quorum Signaling Molecules in Bacterial Cultures and Cystic Fibrosis Sputum Samples through Cationic Surfactant-Assisted Membrane Disruption' Buzid, Alyah; Reen, F. Jerry; Langsi, Victor K.; Muimhneacháin, Eoin Ó; O'Gara, Fergal; McGlacken, Gerard P.; Luong, John H. T.; Glennon, Jeremy D. (2017) 'Direct and Rapid Electrochemical Detection of Pseudomonas aeruginosa Quorum Signaling Molecules in Bacterial Cultures and Cystic Fibrosis Sputum Samples through Cationic Surfactant-Assisted Membrane Disruption'. ChemElectroChem, [DOI] [Full Text] [Details] | |
| (2017) | 'Disruption of N-acyl-homoserine lactone-specific signalling and virulence in clinical pathogens by marine sponge bacteria' Gutierrez-Barranquero, J. A.,Reen, F. J.,Parages, M. L.,McCarthy, R.,Dobson, A. D. W.,O'Gara, F. (2017) 'Disruption of N-acyl-homoserine lactone-specific signalling and virulence in clinical pathogens by marine sponge bacteria'. Microb Biotechnol, [DOI] [Details] | |
| (2017) | 'The requirements at the C-3 position of alkylquinolones for signalling in Pseudomonas aeruginosa' Shanahan, R.,Reen, F. J.,Cano, R.,O'Gara, F.,McGlacken, G. P. (2017) 'The requirements at the C-3 position of alkylquinolones for signalling in Pseudomonas aeruginosa'. Org Biomol Chem, 15 (2):306-310 [DOI] [Details] | |
| (2016) | 'Bile acids destabilise HIF-1alpha and promote anti-tumour phenotypes in cancer cell models' Phelan, J. P.,Reen, F. J.,Dunphy, N.,O'Connor, R.,O'Gara, F. (2016) 'Bile acids destabilise HIF-1alpha and promote anti-tumour phenotypes in cancer cell models'. BMC Cancer, 16 [DOI] [Details] | |
| (2016) | 'Harnessing bacterial signals for suppression of biofilm formation in the nosocomial fungal pathogen Aspergillus fumigatus' Reen, F. Jerry; Phelan,John P.; Woods, David F.; Shanahan, Rachel; Cano, Rafael; Clarke, Sarah; McGlacken, Gerard P.; O’Gara, Fergal (2016) 'Harnessing bacterial signals for suppression of biofilm formation in the nosocomial fungal pathogen Aspergillus fumigatus'. Frontiers In Microbiology, 7 (2074) [DOI] [Full Text] [Details] | |
| (2016) | 'Dissecting the regulation of bile-induced biofilm formation in Staphylococcus aureus' Ulluwishewa, Dulantha; Wang, Liang; Pereira, Callen; Flynn, Stephanie; Cain, Elizabeth; Stick, Stephen; Reen, F. Jerry; Ramsay, Joshua P.; O’Gara, Fergal (2016) 'Dissecting the regulation of bile-induced biofilm formation in Staphylococcus aureus'. Microbiology, 162 (8):1398-1406 [DOI] [Full Text] [Details] | |
| (2016) | 'Molecular Signature of Pseudomonas aeruginosa with Simultaneous Nanomolar Detection of Quorum Sensing Signaling Molecules at a Boron-Doped Diamond Electrode' Buzid, A.,Shang, F.,Reen, F. J.,Muimhneachain, E. O.,Clarke, S. L.,Zhou, L.,Luong, J. H.,O'Gara, F.,McGlacken, G. P.,Glennon, J. D. (2016) 'Molecular Signature of Pseudomonas aeruginosa with Simultaneous Nanomolar Detection of Quorum Sensing Signaling Molecules at a Boron-Doped Diamond Electrode'. Sci Rep, 6 [DOI] [Details] | |
| (2016) | 'Integrated (Meta) Genomic and Synthetic Biology Approaches to Develop New Biocatalysts' Parages, M. L.,Gutierrez-Barranquero, J. A.,Reen, F. J.,Dobson, A. D.,O'Gara, F. (2016) 'Integrated (Meta) Genomic and Synthetic Biology Approaches to Develop New Biocatalysts'. Mar Drugs, 14 (3) [DOI] [Details] | |
| (2016) | 'Is There Potential for Repurposing Statins as Novel Antimicrobials?' Hennessy, Emma; Adams, Claire; Reen, F. Jerry; O'Gara, Fergal (2016) 'Is There Potential for Repurposing Statins as Novel Antimicrobials?'. Antimicrob Agents Chemother, 60 (9):5111-21 [DOI] [Full Text] [Details] | |
| (2016) | 'Synthesis and electrochemical detection of a thiazolyl-indole natural product isolated from the nosocomial pathogen Pseudomonas aeruginosa' Buzid, A.,Muimhneachain, E. O.,Reen, F. J.,Hayes, P. E.,Pardo, L. M.,Shang, F.,O'Gara, F.,Sperry, J.,Luong, J. H.,Glennon, J. D.,McGlacken, G. P. (2016) 'Synthesis and electrochemical detection of a thiazolyl-indole natural product isolated from the nosocomial pathogen Pseudomonas aeruginosa'. Anal Bioanal Chem, 408 (23):6361-7 [DOI] [Details] | |
| (2016) | 'Bile signalling promotes chronic respiratory infections and antibiotic tolerance' Reen, F. J.,Flynn, S.,Woods, D. F.,Dunphy, N.,Chroinin, M. N.,Mullane, D.,Stick, S.,Adams, C.,O'Gara, F. (2016) 'Bile signalling promotes chronic respiratory infections and antibiotic tolerance'. Sci Rep, 6 [DOI] [Details] | |
| (2016) | 'Exploiting Interkingdom Interactions for Development of Small-Molecule Inhibitors of Candida albicans Biofilm Formation' Reen, F. J.,Phelan, J. P.,Gallagher, L.,Woods, D. F.,Shanahan, R. M.,Cano, R.,O. Muimhneachain E,McGlacken, G. P.,O'Gara, F. (2016) 'Exploiting Interkingdom Interactions for Development of Small-Molecule Inhibitors of Candida albicans Biofilm Formation'. Antimicrob Agents Chemother, 60 (10):5894-905 [DOI] [Details] | |
| (2016) | 'Comparative Genomic Analysis Reveals a Diverse Repertoire of Genes Involved in Prokaryote-Eukaryote Interactions within the Pseudovibrio Genus' Romano, S.,Fernandez-Guerra, A.,Reen, F. J.,Glockner, F. O.,Crowley, S. P.,O'Sullivan, O.,Cotter, P. D.,Adams, C.,Dobson, A. D.,O'Gara, F. (2016) 'Comparative Genomic Analysis Reveals a Diverse Repertoire of Genes Involved in Prokaryote-Eukaryote Interactions within the Pseudovibrio Genus'. Front Microbiol, 7 [DOI] [Details] | |
| (2016) | 'Determining the Influence of Small Molecules on Hypoxic Prostate Cancer Cell (DU-145) Viability Using Automated Cell Counting and a Cell Harvesting Protocol' Phelan, J.P. ,Reen, F.J. ,O’Gara, F (2016) 'Determining the Influence of Small Molecules on Hypoxic Prostate Cancer Cell (DU-145) Viability Using Automated Cell Counting and a Cell Harvesting Protocol'. Bio-Protocol, 6 (22) [Details] | |
| (2015) | 'Emerging Concepts promising New Horizons for Marine Biodiscovery and Synthetic Biology' Reen, F.J., Gutierrez-Barranquero, J., Adams, C. and O'Gara, F. (2015) 'Emerging Concepts promising New Horizons for Marine Biodiscovery and Synthetic Biology'. Marine Drugs, 13 (5):2924-2954 [DOI] [Details] | |
| (2015) | 'Deciphering the role of coumarin as a novel quorum sensing inhibitor suppressing virulence phenotypes in bacterial pathogens' Gutierrez-Barranquero, J.A., Reen, F.J., McCarthy, R.R. and O’Gara, F. (2015) 'Deciphering the role of coumarin as a novel quorum sensing inhibitor suppressing virulence phenotypes in bacterial pathogens'. Applied Microbiology and Biotechnology, :3303-3316 [DOI] [Details] | |
| (2015) | 'The Sound of Silence: Activating Silent Biosynthetic Gene Clusters in Marine Microorganisms' Reen, F. J.,Romano, S.,Dobson, A. D.,O'Gara, F. (2015) 'The Sound of Silence: Activating Silent Biosynthetic Gene Clusters in Marine Microorganisms'. Mar Drugs, 13 (8):4754-83 [DOI] [Details] | |
| (2015) | 'A structure activity-relationship study of the bacterial signal molecule HHQ reveals swarming motility inhibition in Bacillus atrophaeus' Reen, F. J.,Shanahan, R.,Cano, R.,O'Gara, F.,McGlacken, G. P. (2015) 'A structure activity-relationship study of the bacterial signal molecule HHQ reveals swarming motility inhibition in Bacillus atrophaeus'. Org Biomol Chem, 13 (19):5537-41 [DOI] [Details] | |
| (2015) | 'Minimum Information about a Biosynthetic Gene cluster' Medema, M. H.,Kottmann, R.,Yilmaz, P.,Cummings, M.,Biggins, J. B.,Blin, K.,de Bruijn, I.,Chooi, Y. H.,Claesen, J.,Coates, R. C.,Cruz-Morales, P.,Duddela, S.,Dusterhus, S.,Edwards, D. J.,Fewer, D. P.,Garg, N.,Geiger, C.,Gomez-Escribano, J. P.,Greule, A.,Hadjithomas, M.,Haines, A. S.,Helfrich, E. J.,Hillwig, M. L.,Ishida, K.,Jones, A. C.,Jones, C. S.,Jungmann, K.,Kegler, C.,Kim, H. U.,Kotter, P.,Krug, D.,Masschelein, J.,Melnik, A. V.,Mantovani, S. M.,Monroe, E. A.,Moore, M.,Moss, N.,Nutzmann, H. W.,Pan, G.,Pati, A.,Petras, D.,Reen, F. J.,Rosconi, F.,Rui, Z.,Tian, Z.,Tobias, N. J.,Tsunematsu, Y.,Wiemann, P.,Wyckoff, E.,Yan, X.,Yim, G.,Yu, F.,Xie, Y.,Aigle, B.,Apel, A. K.,Balibar, C. J.,Balskus, E. P.,Barona-Gomez, F.,Bechthold, A.,Bode, H. B.,Borriss, R.,Brady, S. F.,Brakhage, A. A.,Caffrey, (2015) 'Minimum Information about a Biosynthetic Gene cluster'. Nat Chem Biol, 11 (9):625-31 [DOI] [Details] | |
| (2014) | 'Tle Distribution and Diversity in Metagenomic Datasets Reveals Niche Specialisation' Egan, F., Reen, F.J. and O'Gara, F. (2014) 'Tle Distribution and Diversity in Metagenomic Datasets Reveals Niche Specialisation'. [Details] | |
| (2014) | 'Bile acids repress hypoxia-inducible factor-1 (HIF-1) signaling and modulate the airway immune response' Legendre, C., Mooij, M.J., Woods, D., Adams, C., Reen, F.J., and O’Gara, F. (2014) 'Bile acids repress hypoxia-inducible factor-1 (HIF-1) signaling and modulate the airway immune response'. Infection And Immunityinfection And Immunity, 82 (9) [Details] | |
| (2014) | 'Aspirated bile: a major host trigger modulating respiratory pathogen colonisation in cystic fibrosis patients' Reen, F. J.,Woods, D. F.,Mooij, M. J.,Chroinin, M. N.,Mullane, D.,Zhou, L.,Quille, J.,Fitzpatrick, D.,Glennon, J. D.,McGlacken, G. P.,Adams, C.,O'Gara, F. (2014) 'Aspirated bile: a major host trigger modulating respiratory pathogen colonisation in cystic fibrosis patients'. Eur J Clin Microbiol Infect Dis, 33 (10):1763-71 [DOI] [Details] | |
| (2014) | 'Inhibition of co-colonising cystic fibrosis-associated pathogens by Pseudomonas aeruginosa and Burkholderia multivorans' Costello, A., Reen, F.J., O’Gara, F., Callaghan, M., McClean, S. (2014) 'Inhibition of co-colonising cystic fibrosis-associated pathogens by Pseudomonas aeruginosa and Burkholderia multivorans'. Microbiology, 160 :1474-1487 [Details] | |
| (2014) | 'Characterisation of non-autoinducing tropodithietic Acid (TDA) production from marine sponge Pseudovibrio species' Harrington, C.,Reen, F. J.,Mooij, M. J.,Stewart, F. A.,Chabot, J. B.,Guerra, A. F.,Glockner, F. O.,Nielsen, K. F.,Gram, L.,Dobson, A. D.,Adams, C.,O'Gara, F. (2014) 'Characterisation of non-autoinducing tropodithietic Acid (TDA) production from marine sponge Pseudovibrio species'. Mar Drugs, 12 (12):5960-78 [DOI] [Details] | |
| (2014) | 'A new regulator of pathogenicity (bvlR) is required for full virulence and tight microcolony formation in Pseudomonas aeruginosa' McCarthy R.R., Mooij, M.J., Reen, F.J., Lesouhaitier, O., and O'Gara, F. (2014) 'A new regulator of pathogenicity (bvlR) is required for full virulence and tight microcolony formation in Pseudomonas aeruginosa'. Microbiology, 160 :1488-1500 [DOI] [Details] | |
| (2014) | 'One step preparation and electrochemical analysis of IQS, a cell-cell communication signal in the nosocomial pathogen Pseudomonas aeruginosa' Shang F, Muimhneacháin EÓ, Reen FJ, Buzid A, O'Gara F, Luong JH, Glennon JD, McGlacken GP (2014) 'One step preparation and electrochemical analysis of IQS, a cell-cell communication signal in the nosocomial pathogen Pseudomonas aeruginosa'. Bioorganic and Medicinal Chemistry Letters, 24 (19):4703-4707 [DOI] [Details] | |
| (2013) | 'Statins inhibit in vitro virulence phenotypes of Pseudomonas aeruginosa' Hennessy, E.,Mooij, M. J.,Legendre, C.,Reen, F. J.,O'Callaghan, J.,Adams, C.,O'Gara, F. (2013) 'Statins inhibit in vitro virulence phenotypes of Pseudomonas aeruginosa'. J Antibiot (Tokyo), 66 (2):99-101 [DOI] [Details] | |
| (2013) | 'A non-classical LysR-type transcriptional regulator PA2206 is required for an effective oxidative stress response in Pseudomonas aeruginosa' Reen, F. J.,Haynes, J. M.,Mooij, M. J.,O'Gara, F. (2013) 'A non-classical LysR-type transcriptional regulator PA2206 is required for an effective oxidative stress response in Pseudomonas aeruginosa'. PLoS One, 8 (1) [DOI] [Details] | |
| (2013) | 'Molecular evolution of LysR-type transcriptional regulation in Pseudomonas aeruginosa' Reen, F. J.,Barret, M.,Fargier, E.,O'Muinneachain, M.,O'Gara, F. (2013) 'Molecular evolution of LysR-type transcriptional regulation in Pseudomonas aeruginosa'. Mol Phylogenet Evol, 66 (3):1041-9 [DOI] [Details] | |
| (2012) | 'Structure-function analysis of the C-3 position in analogues of microbial behavioural modulators HHQ and PQS' Reen, F. J.,Clarke, S. L.,Legendre, C.,McSweeney, C. M.,Eccles, K. S.,Lawrence, S. E.,O'Gara, F.,McGlacken, G. P. (2012) 'Structure-function analysis of the C-3 position in analogues of microbial behavioural modulators HHQ and PQS'. Org Biomol Chem, 10 (44):8903-10 [DOI] [Details] | |
| (2012) | 'Structure–function analysis of the C-3 position in analogues of microbial behavioural modulators HHQ and PQS' Reen, F. Jerry; Clarke, Sarah L.; Legendre, Claire; McSweeney, Christina M.; Eccles, Kevin S.; Lawrence, Simon E.; O'Gara, Fergal; McGlacken, Gerard P (2012) 'Structure–function analysis of the C-3 position in analogues of microbial behavioural modulators HHQ and PQS'. Organic and Biomolecular Chemistry, 10 (44):8903-8910 [Details] | |
| (2012) | 'Pseudomonas aeruginosa Alkyl quinolones repress hypoxia-inducible factor 1 (HIF-1) signaling through HIF-1alpha degradation' Legendre, C.,Reen, F. J.,Mooij, M. J.,McGlacken, G. P.,Adams, C.,O'Gara, F. (2012) 'Pseudomonas aeruginosa Alkyl quinolones repress hypoxia-inducible factor 1 (HIF-1) signaling through HIF-1alpha degradation'. Infect Immun, 80 (11):3985-92 [DOI] [Details] | |
| (2012) | 'Analysis of Pseudomonas quinolone signal and other bacterial signalling molecules using capillaries coated with highly charged polyelectrolyte monolayers and boron doped diamond electrode' Zhou, L.,Reen, F. J.,O'Gara, F.,McSweeney, C. M.,Clarke, S. L.,Glennon, J. D.,Luong, J. H.,McGlacken, G. P. (2012) 'Analysis of Pseudomonas quinolone signal and other bacterial signalling molecules using capillaries coated with highly charged polyelectrolyte monolayers and boron doped diamond electrode'. J Chromatogr A, 1251 :169-75 [DOI] [Details] | |
| (2012) | 'Analysis of pseudomonas quinolone signal and other bacterial signalling molecules using capillaries coated with highly charged polyelectrolyte monolayers and boron doped diamond electrode' Zhou, Lin; Reen, F. Jerry; O'Gara, Fergal; McSweeney, Christina M.; Clarke, Sarah L.; Glennon, Jeremy D.; Luong, John H. T.; McGlacken, Gerard P. (2012) 'Analysis of pseudomonas quinolone signal and other bacterial signalling molecules using capillaries coated with highly charged polyelectrolyte monolayers and boron doped diamond electrode'. Journal of Chromatography A, 1251 :169-175 [Details] | |
| (2012) | 'A novel host-responsive sensor mediates virulence and type III secretion during Pseudomonas aeruginosa-host cell interactions' O'Callaghan, J.,Reen, F. J.,Adams, C.,Casey, P. G.,Gahan, C. G.,O'Gara, F. (2012) 'A novel host-responsive sensor mediates virulence and type III secretion during Pseudomonas aeruginosa-host cell interactions'. Microbiology, 158 (Pt 4):1057-70 [DOI] [Details] | |
| (2012) | 'Respiratory pathogens adopt a chronic lifestyle in response to bile' Reen, F. J.,Woods, D. F.,Mooij, M. J.,Adams, C.,O'Gara, F. (2012) 'Respiratory pathogens adopt a chronic lifestyle in response to bile'. PLoS One, 7 (9) [DOI] [Details] | |
| (2011) | 'Low oxygen induces the type III secretion system in Pseudomonas aeruginosa via modulation of the small RNAs rsmZ and rsmY' O'Callaghan, J.,Reen, F. J.,Adams, C.,O'Gara, F. (2011) 'Low oxygen induces the type III secretion system in Pseudomonas aeruginosa via modulation of the small RNAs rsmZ and rsmY'. Microbiology, 157 (Pt 12):3417-28 [DOI] [Details] | |
| (2011) | 'The Pseudomonas quinolone signal (PQS), and its precursor HHQ, modulate interspecies and interkingdom behaviour' Reen, F.J., Mooij, M.J., Holcombe, L.J., McSweeney, C.M., McGlacken, G.P., Morrissey, J.P., and O'Gara, F.; (2011) 'The Pseudomonas quinolone signal (PQS), and its precursor HHQ, modulate interspecies and interkingdom behaviour'. FEMS Microbiol Ecol, 77 (2):413-428 [DOI] [Details] | |
| (2011) | 'The Pseudomonas quinolone signal (PQS), and its precursor HHQ, modulate interspecies and interkingdom behaviour' Reen, F. J.,Mooij, M. J.,Holcombe, L. J.,McSweeney, C. M.,McGlacken, G. P.,Morrissey, J. P.,O'Gara, F. (2011) 'The Pseudomonas quinolone signal (PQS), and its precursor HHQ, modulate interspecies and interkingdom behaviour'. FEMS Microbiol Ecol, 77 (2):413-28 [DOI] [Details] | |
| (2011) | 'Detection of the Pseudomonas Quinolone Signal (PQS) by cyclic voltammetry and amperometry using a boron doped diamond electrode' Zhou, L.,Glennon, J. D.,Luong, J. H.,Reen, F. J.,O'Gara, F.,McSweeney, C.,McGlacken, G. P. (2011) 'Detection of the Pseudomonas Quinolone Signal (PQS) by cyclic voltammetry and amperometry using a boron doped diamond electrode'. Chem Commun (Camb), 47 (37):10347-9 [DOI] [Details] | |
| (2011) | 'Low oxygen induces the T3SS in Pseudomonas aeruginosa via modulation of the small RNAs, rsmZ and rsmY' O’Callaghan, J., Reen, F.J., Adams, C., and O'Gara, F. (2011) 'Low oxygen induces the T3SS in Pseudomonas aeruginosa via modulation of the small RNAs, rsmZ and rsmY'. Microbiology, [DOI] [Details] | |
| (2011) | 'Detection of the Pseudomonas Quinolone Signal (PQS) by cyclic voltammetry and amperometry using a boron doped diamond electrode' Zhou, L., Glennon, J.D., Luong, J.H.T., Reen, F.J., O'Gara, F., McSweeney, C., and McGlacken, G.P.; (2011) 'Detection of the Pseudomonas Quinolone Signal (PQS) by cyclic voltammetry and amperometry using a boron doped diamond electrode'. Chemical Communications, 47 (37):10347-10349 [DOI] [Details] | |
| (2010) | 'Synthesis of 3-halo-analogues of HHQ, subsequent cross-coupling and first crystal structure of Pseudomonas Quinolone Signal, PQS' McGlacken, Gerard P., McSweeney, Christina M., O'Brien, Timothy, Lawrence, Simon E., Elcoate, Curtis J., Reen, F. Jerry, and O'Gara, Fergal; (2010) 'Synthesis of 3-halo-analogues of HHQ, subsequent cross-coupling and first crystal structure of Pseudomonas Quinolone Signal, PQS'. Tetrahedron Letters, 51 :5919-5921 [DOI] [Details] | |
| (2009) | 'Subinhibitory concentrations of the cationic antimicrobial peptide colistin induce the pseudomonas quinolone signal in Pseudomonas aeruginosa' Cummins, J.,Reen, F. J.,Baysse, C.,Mooij, M. J.,O'Gara, F. (2009) 'Subinhibitory concentrations of the cationic antimicrobial peptide colistin induce the pseudomonas quinolone signal in Pseudomonas aeruginosa'. Microbiology, 155 (Pt 9):2826-37 [DOI] [Details] | |
| (2009) | 'Sensitive and rapid molecular detection assays for Salmonella enterica serovars Typhimurium and Heidelberg' McCarthy, N.,Reen, F. J.,Buckley, J. F.,Frye, J. G.,Boyd, E. F.,Gilroy, D. (2009) 'Sensitive and rapid molecular detection assays for Salmonella enterica serovars Typhimurium and Heidelberg'. J Food Prot, 72 (11):2350-7 [Details] | |
| (2008) | 'Rapid multiplex PCR and real-time TaqMan PCR assays for detection of Salmonella enterica and the highly virulent serovars Choleraesuis and Paratyphi C' Woods, D. F.,Reen, F. J.,Gilroy, D.,Buckley, J.,Frye, J. G.,Boyd, E. F. (2008) 'Rapid multiplex PCR and real-time TaqMan PCR assays for detection of Salmonella enterica and the highly virulent serovars Choleraesuis and Paratyphi C'. J Clin Microbiol, 46 (12):4018-22 [DOI] [Details] | |
| (2006) | 'The genomic code: inferring Vibrionaceae niche specialization' Reen, F. J.,Almagro-Moreno, S.,Ussery, D.,Boyd, E. F. (2006) 'The genomic code: inferring Vibrionaceae niche specialization'. Nat Rev Microbiol, 4 (9):697-704 [DOI] [Details] | |
| (2006) | 'Genomic island identification in Vibrio vulnificus reveals significant genome plasticity in this human pathogen' Quirke, A. M.,Reen, F. J.,Claesson, M. J.,Boyd, E. F. (2006) 'Genomic island identification in Vibrio vulnificus reveals significant genome plasticity in this human pathogen'. Bioinformatics, 22 (8):905-10 [DOI] [Details] | |
| (2006) | 'Four genomic islands that mark post-1995 pandemic Vibrio parahaemolyticus isolates' Hurley, C. C.,Quirke, A.,Reen, F. J.,Boyd, E. F. (2006) 'Four genomic islands that mark post-1995 pandemic Vibrio parahaemolyticus isolates'. BMC Genomics, 7 [DOI] [Details] | |
| (2005) | 'Genomic comparisons of Salmonella enterica serovar Dublin, Agona, and Typhimurium strains recently isolated from milk filters and bovine samples from Ireland, using a Salmonella microarray' Reen, F. J.,Boyd, E. F.,Porwollik, S.,Murphy, B. P.,Gilroy, D.,Fanning, S.,McClelland, M. (2005) 'Genomic comparisons of Salmonella enterica serovar Dublin, Agona, and Typhimurium strains recently isolated from milk filters and bovine samples from Ireland, using a Salmonella microarray'. Appl Environ Microbiol, 71 (3):1616-25 [DOI] [Details] | |
| (2005) | 'Molecular typing of epidemic and nonepidemic Vibrio cholerae isolates and differentiation of V. cholerae and V. mimicus isolates by PCR-single-strand conformation polymorphism analysis' Reen, F. J.,Boyd, E. F. (2005) 'Molecular typing of epidemic and nonepidemic Vibrio cholerae isolates and differentiation of V. cholerae and V. mimicus isolates by PCR-single-strand conformation polymorphism analysis'. J Appl Microbiol, 98 (3):544-55 [DOI] [Details] | |
| (2004) | 'The {Vibrio} seventh pandemic island-II is a 26.9 kb genomic island present in {Vibrio cholerae} El Tor and O139 serogroup isolates that shows homology to a 43.4 kb genomic island in {V. vulnificus}' O'Shea, Y.A., Finnan, S., Reen, F.J., Morrissey, J.P., O'Gara, F., and Boyd, E.F.; (2004) 'The {Vibrio} seventh pandemic island-II is a 26.9 kb genomic island present in {Vibrio cholerae} El Tor and O139 serogroup isolates that shows homology to a 43.4 kb genomic island in {V. vulnificus}'. Microbiology, 150.12 (*):4053-4063 [Details] | |
| (2004) | 'Evolutionary genetic analysis of the emergence of epidemic Vibrio cholerae isolates on the basis of comparative nucleotide sequence analysis and multilocus virulence gene profiles' O'Shea, Y. A.,Reen, F. J.,Quirke, A. M.,Boyd, E. F. (2004) 'Evolutionary genetic analysis of the emergence of epidemic Vibrio cholerae isolates on the basis of comparative nucleotide sequence analysis and multilocus virulence gene profiles'. J Clin Microbiol, 42 (10):4657-71 [DOI] [Details] | |
| (2003) | 'Molecular characterisation and expression analysis of the first hemicellulase gene (bxl1) encoding beta-xylosidase from the thermophilic fungus Talaromyces emersonii' Reen, F. J.,Murray, P. G.,Tuohy, M. G. (2003) 'Molecular characterisation and expression analysis of the first hemicellulase gene (bxl1) encoding beta-xylosidase from the thermophilic fungus Talaromyces emersonii'. Biochem Biophys Res Commun, 305 (3):579-85 [Details] |
Conference Publications
| Year | Publication | |
|---|---|---|
| (2021) | North American Cystic Fibrosis Conference Caparros-Martin, J.A., Saladie, M., Agudelo-Romero, P., Reen, F.J., Ware, R., Sly, P., Stick, S.M. and O’Gara, F. (2021) Bile acids, bacterial colonization, and lung inflammatory markers in infants with cystic fibrosis North American Cystic Fibrosis Conference , pp.S230-S231 [DOI] [Details] | |
| (2019) | Microbes in Medicine Reen, F.J. (2019) Socially messaging polycellular interactomes for innovative interventions in health and medicine Microbes in Medicine [DOI] [Details] | |
| (2015) | Irish Thoracic Society Annual Scientific Meeting Reen, F.J., Flynn, S., Woods, D., Ní Chróinín MN, Mullane D, Stick, S., Adams, C. and O’Gara, F. (2015) Intercepting the Bile Aspiration Paradigm: Innovative Intervention for Chronic Respiratory Disease Irish Thoracic Society Annual Scientific Meeting [Details] | |
| (2014) | Irish Thoracic Society Annual Scientific Meeting Reen, F.J., Woods, D., Flynn, S., Ní Chróinín MN, Mullane D, Stick, S., Adams, C. and O’Gara, F. (2014) Translational research for chronic respiratory disease: intercepting the bile aspiration paradigm Irish Thoracic Society Annual Scientific Meeting [Details] | |
| (2012) | Mycoses Morrissey, JP,Reen, J,Holcombe, L,de Vasconcelos, FNL,O'Gara, F. (2012) Interspecies signaling between Pseudomonas and Candida Mycoses [Details] | |
| (2006) | 36th Annual Research Conference on Food Nutrition and Consumer Foods McCarthy, N., Reen, F.J., Gilroy, D., Buckley, J. and E.F. Boyd. (2006) Development of PCR assays to detect and characterise Salmonella enterica isolates by utilising an integrated genomics approach 36th Annual Research Conference on Food Nutrition and Consumer Foods [Details] | |
| (2006) | 36th Annual Research Conference on Food Nutrition and Consumer Foods Woods, D., Reen, F.J., Gilroy, D., Buckley, J. and E.F. Boyd. (2006) Bioinformatic analysis of the genomes of Salmonella for the development of rapid identification by PCR 36th Annual Research Conference on Food Nutrition and Consumer Foods [Details] |
Professional Activities
Honours and Awards
| Year | Title | Awarding Body | |
|---|---|---|---|
| 2022 | Bronze LEAF Award | Green Campus University College Cork | |
| 2021 | The Disciplinary Excellence in Learning, Teaching and Assessment (DELTA) Award | National Forum for the Enhancement of Teaching and Learning | |
| 2016 | Purdy-Lucey UCC Life Sciences Invention of the Year 2015 | Office of Technology Transfer, UCC | |
| 2015 | 'You in Youtube’ Outreach Competition | School of Microbiology, UCC | |
| 2012 | Best Poster Exhibition | Royal Irish Academy | |
| 2011 | National Researcher of the Year, Silver Medal | Roche | |
| 2011 | BioSciences Researcher of the Year, Gold Medal | Roche | |
| 2011 | Technology Start-Up Entrepreneurship Programme | SFI and DCU Ryan Academy |
Professional Associations
| Association | Function | From / To | |
|---|---|---|---|
| Irish Research Council for Science Engineering and Technology | PostDoctoral Fellow | 01-OCT-04 / 01-MAR-07 | |
| Institute of Leadership Management | Scholar | 05-OCT-15 / 31-DEC-16 |
Patents
| Patent Number | Title | Granted | |
|---|---|---|---|
| WO2007091231A1 | Talaromyces emersonii enzyme systems | 22-JAN-09 | |
| 1513614.6, UCC | Small molecules for biofilm prevention | 31-JUL-16 |
Committees
| Committee | Function | From / To | |
|---|---|---|---|
| Academic Council Graduate Studies Committee | SEFS Representative | 2023 / | |
| CK402 Board of Studies | Chair, Programme Director | 2023 / | |
| Microbiology Society Scientific Conferences Panel | Member | 2022 / | |
| Microbiology Society Building Communities | Member | 2022 / | |
| SEFS Committee for External Engagement | Member | 2022 / | |
| Bord na Gaeilge | College of SEFS Representative | 2020 / | |
| Irish Division of the Microbiology Society | Chair-Elect | 2020 / | |
| School of Microbiology Graduate Studies Committee | Chair | 2019 / | |
| SEFS Graduate Studies Committee | School of Microbiology Representative | 2019 / |
Education
| Year | Institution | Qualification | Subject | |
|---|---|---|---|---|
| 2022 | University College Cork | MATLHE | The use of virtual reality for teaching and learning in molecular and cellular sciences. | |
| 2017 | Wellcome Trust and Open University | Certificate | International Funders Award | |
| 2016 | Institute of Leadership Management and UCC | Certificate | Professional Skills for Research Leaders | |
| 2015 | NUI-UCC | Postgraduate Diploma | Teaching and Learning in Higher Education | |
| 2014 | NUI-UCC | Postgraduate Certificate | Teaching and Learning in Higher Education | |
| 2013 | Confucius Centre, UCC | Certificate of Merit | Beginners Chinese | |
| 2011 | DCU Ryan Academy | Certificate of Merit | Get Started Technology Venture Entrepreneurship Programme | |
| 2007 | UCC | Certificate | Irish and UK Accreditation for Animal Research |
Languages
| Language | Reading | Writing | Speaking | |
|---|---|---|---|---|
| Gaeilge | Fluent | Fluent | Fluent | |
| English | Fluent | Fluent | Fluent |
Outreach Activities
| Description | |
|---|---|
Hosted BT Young Scientist students dealing with aspects of biofilm formation | |
A pilot programme for second level schools to explore cells and molecular structures through visual simulations in immersive virtual reality. | |
Moltóir Bleaist Eolaíochta (ESB Science Blast Judge) | |
Member of Enterprise Ireland focus group on Research Commercialisation | |
Deliver a science show at local Gaelscoil 'as gaeilge' |
Journal Activities
| Journal | Role | To / From | |
|---|---|---|---|
| Fems Microbiology Letters | Referee | - | |
| Microbial Biotechnology | Referee | - | |
| Canadian Journal Of Microbiology | Referee | - | |
| Antimicrobial Agents And Chemotherapy | Referee | - | |
| Frontiers In Microbiology | Referee | - | |
| Isme Journal | Referee | - | |
| Journal Of Medical Microbiology | Referee | - | |
| Plos One | Referee | - | |
| Journal Of Antimicrobial Chemotherapy | Referee | - |
Other Activities
| Description | |
|---|---|
Moderator of Expert Panel on Nagoya Protocol, Marine Microbiome Discovery and Innovation, Industry Conference, Berlin, Germany 2016 |
Teaching Activities
Teaching Interests
Thematic Areas:
Teaching interests reflect a strong commitment to research and innovation in medicine and health, sustainable ecosystems, and microbial biotechnology.
(i) The molecular ecological basis of how microbial communities interact with their host and their ecosystem is a key teaching interest sustained over many years, underpinned by a commitment to foster an interest amongst the students for what amount to the greatest challenges of our time.
(ii) Advanced molecular and systems biotechnology with an emphasis on microbial systems that can deliver sustainable green solutions for Pharma and Industry.
(iii) Microbe-host interactions and bi-directional signalling/communication in the context of clinical and environmental ecosystems. Small molecule signalling, signal transduction systems, and virulence control within complex polymicrobial communities.
(iv) Genetically Modified Microorganisms for Adult Continuing Education and the Pharmaceutical Industry.
Pedagogical Innovations:
Student partnered innovation in learning and assessment is a keen and sustained interest of mine.
(i) Teaching innovations developed around 'learning by doing' through e.g. signal transduction enactment, molecular jigsaws
(ii) Applied performances of understanding e.g. Molecular Canvas
(iii) Cross-discipline internationalisation
(iv) Digitalisation e,g, Bespoke award winning Virtual Reality simulations
Scholarship of Inclusive Teaching and Learning:
Commitment to the research and scholarship underpinning Universal Design for Learning and inclusive neurodiverse teaching.
(i) Publication in discipline peer-reviewed journals
(ii) Provision of student-partnered insights for digital badge initiatives
(iii) Student perspectives on how module learning outcomes can address UN SDG challenges
Teaching Portfolio 2000-present
NUI Galway – Demonstration/tutorials. Organisation and delivery of Biochemistry Laboratory induction programme for final year students.
UCC – ML6002 Biological and Clinical Perspectives of Human Disease; ML6004 Cell and Molecular Biology; MB4004 Physiology of the Bacterial Cell; GN4002/MB4016 Laboratory Research Projects; MB4026 Molecular Biology and Physiology of Bacteria; MB4025 Eukaryotic Molecular Genetics; MB4027 Research Frontiers in Microbiology; MB3007 Molecular Biology; MB3012 Transmission & Epidemiology of Infectious Disease; MB3014 Food and Industrial Microbiology II; MB3016 Microbiology Methods; MB2003 Fundamental Principles of Microbiology; MB2006 Principles of Microbiology; BL1002 Cells, Biomolecules, Genetics & Evolution.
Module Coordinator: BT4002 Biotechnology Research Projects; BT4004 Microbial Biotechnology; MB3005; The role and ecology of microbes in the environment; MB3006 Genetic Engineering and Molecular Biotechnology; MB3017 Themes in microbe-host interactions.
UCC Adult Continuing Education – DENVSP II.
UCC Skills Centre: Designed and prepared modules on scientific writing and academic poster presentation.
Pharmaceutical Industry: GMO Technology Training Course (six modules) prepared & delivered to leading Cork-based multinational pharmaceutical company (Oct/Nov 2007 and May/Jun 2008)
Recent Postgraduates
| Graduation Year | Student Name | Institution | Degree Type | Thesis Title | |
|---|---|---|---|---|---|
| 2019 | Stephanie Flynn | University College Cork | PHD | Understanding the Molecular Mechanism through which Aspirated Bile Triggers Chronic Pseudomonas aeruginosa Infections in Respiratory Disease | |
| 2009 | Noelle McCarthy | Cork Institute of Technology | PhD | Development of PCR assays to detect and characterise Salmonella isolates from cheese and meat products by utilizing an integrated genomics approach | |
| 2008 | David Woods | University College Cork | MSc | Rapid multiplex PCR and real-time TaqMan PCR assays for detection of Salmonella enterica and the highly virulent serovars Choleraesuis and Paratyphi C |
Current Postgraduate Students
| Student | Degree Type | |
|---|---|---|
| Moore-Machacek Aysha Naomi Cara | Doctoral Degree | |
| Carmody Muireann Edel | Doctoral Degree |
Research Information
Internal Collaborators
| Name | Institute | Country | |
|---|---|---|---|
| Dr Gerard McGlacken | University College Cork | IRELAND | |
| Prof. Jeremy Glennon | University College Cork | IRELAND | |
| Prof. Helena Galvao | University of Faro | PORTUGAL | |
| Dr Niall O'Leary | University College Cork | IRELAND | |
| Prof. Anita Maguire | University College Cork | IRELAND | |
| Dr Stuart Collins | University College Cork | IRELAND |
External Collaborators
| Name | Organisation / Institute | Country | |
|---|---|---|---|
| Dr Pedro A. Sanchez Murcia | Medical University of Graz | AUSTRIA | |
| Dr Claudia Serra | University de Porto | PORTUGAL | |
| Prof. Freya Harrison | University of Warwick | UNITED KINGDOM | |
| Dr Gordon Cooke | TU Dublin | IRELAND |
Contact details
- F. Jerry Reen
Senior Lecturer and Principal Investigator - j.reen@ucc.ie
- MICROBIOLOGY
University College Cork
Cork
Ireland - +353-21-490-1330