Research Profile

F.Jerry Reen

Biography

Dr. F. Jerry Reen did his BSc in Biochemistry at the National University of Ireland Galway. He subsequently pursued a PhD in the Molecular GlycoBiotechnology Group at NUIG, having being awarded both an Enterprise Ireland Scholarship and an NUI Teaching Fellowship. Upon completion of this work in Oct 2002, Jerry took up a PostDoctoral position in the lab of Dr. E. Fidelma Boyd in the Department of Microbiology at UCC. During that time he was a visiting scientist at the Sidney Kimmel Cancer Center, San Diego, USA and was awarded an IRCSET Postdoctoral Fellowship to study bacteriophage-host interactions in Vibrio cholerae. Jerry subsequently took up a lecturing position (fixed term) in the School of Microbiology, while also joining the BIOMERIT Research Centre where he begun to develop an interest in small molecule research and host-microbe interaction in chronic disease. In 2011, he won the inaugural Science Foundation Ireland TIDA ‘Dragons Den’ and was hosted in Silicon Valley, San Jose by the Irish Technology Leadership Group. He has since won several additional awards for his research and has published over 50 peer reviewed scientific papers (h-index 18). Jerry has recently been appointed as a lecturer in the School of Microbiology. His research interests are in small molecule therapeutics and microbe-host interactions in chronic lung disease.

Research Interests

Throughout my research career I have developed a strong interdisciplinary background in biochemistry, microbiology, chemistry, and bioinformatics. This experience has resulted in several interdisciplinary collaborations being established with colleagues from other Schools within UCC and further afield, links which I am keen to continue to develop going forward. Deciphering the common signatures that define distantly related organisms provides a unique perspective on the dynamic interactions that govern their co-existence. From a translational perspective, developing a network of compounds that modulate cellular behaviour provides the template for a synthetic diversity approach that is being used to develop antagonistic compounds for drug development.

Small molecule signalling in microbial communities: The foundation of microbial behaviour, whether the expression of virulence, persistence through community formations called biofilms, or the expression of novel biosynthetic gene clusters and natural products, is governed by cell-cell communication. The emergence of technologies that enable us to appreciate and investigate the microbial communities that colonise diverse ecological and clinical niches has led to a new understanding of disease progression. The lungs, previously considered a sterile environment periodically colonised by harmful pathogens, are now known to carry a rich and diverse microbial community. Deciphering the cell-cell communication systems that govern the interactions between these diverse species is key to delivering innovative and effective new therapies for disease management. Interactions between established and emerging pathogens is of particular interest. A major part of this discovery based programme is the development of systems-based approaches and appropriate models in which to study microbial behaviour. This will lead to a better understanding of microbial pathogenesis during infection, in light of the diversity within the polymicrobial communities that exist in these ecological niches.

Chemico-biological therapeutics:
As the age of the global population continues to increase year on year, the challenges in maintaining health and quality of life (QoF) continue to exercise the commercial and academic communities. We are and will continue to live longer, and this brings with it its own challenges. Antibiotic-based therapies are under severe pressure due to the continuing emergence of resistant pathogens, while conventional therapies are limited by their target specificities. Furthermore, off target effects of large biologics has led the search for more specific molecular based therapeutics. My research interests lie in pursuing chemico-biological molecular approaches to identify and develop small bioactive molecules. This then provides the basis with which to underpin innovations in therapeutic developments, new biotechnological developments, and next generation solutions, primarily for the pharmaceutical, cosmetic and medical device industries. Furthermore, these natural products also address the environmentally conscious end-user market need for eco-friendly and safe therapeutics.  

(Post)Transcriptional regulatory systems:
Signal perception and transduction through tightly coordinated circuits is integral to the survival and persistence of microbes in diverse ecological niches. The capacity of microbes to adapt to changes in the environment is central to their ability to thrive under adverse circumstances. Signal dependent transcriptional regulators are a key mechanism through which microbes assimilate environmental cues and mediate the appropriate adaptive response. By far the largest class of transcriptional regulator is the LysR-class, which is universally distributed among bacteria, archaea, and even eukaryotic organisms. The number of LysR-Type Transcriptional Regulators (LTTRs) varies among species with one of the largest repertoires encoded in the genome of the nosocomial pathogen Pseudomonas aeruginosa. I am interested in understanding the evolutionary basis for the emergence of this class of transcriptional regulator, and elucidating the hierarchical network that underpins their control of virulence and pathogenesis in nosocomial pathogens.

Research Grants

 ProjectFunding
Body
Start DateEnd DateAward
'BioBloc' enhanced Contact LEns solutioNS (BBCLENS)Enterprise Ireland27-NOV-1726-NOV-18€138,525.00

Publications

Book Chapters

 YearPublication
(2018)'Rapid Electrochemical Detection of Pseudomonas aeruginosa Signaling Molecules by Boron-Doped Diamond Electrode'
Buzid, A.,Luong, J. H. T.,Reen, F. J.,O'Gara, F.,Glennon, J. D.,McGlacken, G. P. (2018) 'Rapid Electrochemical Detection of Pseudomonas aeruginosa Signaling Molecules by Boron-Doped Diamond Electrode' In: Methods Mol Biol. Cambridge (UK): Springer.   [DOI] [Details]
(2017)'Mining Microbial Signals for Enhanced Biodiscovery of Secondary Metabolites'
Reen, F. J.,Gutierrez-Barranquero, J. A.,O'Gara, F. (2017) 'Mining Microbial Signals for Enhanced Biodiscovery of Secondary Metabolites' In: Methods Mol Biol. Cambridge (UK): Springer.   [DOI] [Details]
(2017)'Rapid Electrochemical Detection of Pseudomonas aeruginosa Signaling Molecules by Boron-Doped Diamond Electrode'
Buzid, A., Luong, J.H.T., Reen, F.J., O’Gara, F., Glennon, J.D. and McGlacken, G.P. (2017) 'Rapid Electrochemical Detection of Pseudomonas aeruginosa Signaling Molecules by Boron-Doped Diamond Electrode' In: Leoni L., and Rampioni, G (eds). Quorum Sensing – Methods and Protocols. U.S.A: Sprinter. [DOI] [Details]
(2016)'Metagenomics as a tool for biodiscovery and enhancement of production of bioactives'
Reen F.J. and F. O’Gara. (2016) 'Metagenomics as a tool for biodiscovery and enhancement of production of bioactives' In: Stahl, L and Creitou, M.S (eds). The marine microbiome – an untold resource of biodiversity and biotechnological potential. USA: Springer. [DOI] [Details]
(2016)'Bile Aspiration; a host factor modulating chronic respiratory infection'
Flynn, S., Woods, D., Ní Chróinín, M., Mullane, D., Adams, C., Reen, F.J. & F O’Gara. (2016) 'Bile Aspiration; a host factor modulating chronic respiratory infection' In: Johnston, N. & Toohill, R.J (eds). Bile Acids: Biosynthesis, Metabolic Regulation and Biological Functions. USA: Nova Science Publishers. [Details]

Peer Reviewed Journals

 YearPublication
(2017)'Statin therapy causes gut dysbiosis in mice through a PXR-dependent mechanism'
Caparros-Martin, J. A.,Lareu, R. R.,Ramsay, J. P.,Peplies, J.,Reen, F. J.,Headlam, H. A.,Ward, N. C.,Croft, K. D.,Newsholme, P.,Hughes, J. D.,O'Gara, F. (2017) 'Statin therapy causes gut dysbiosis in mice through a PXR-dependent mechanism'. Microbiome, 5 (1)   [DOI] [Details]
(2017)'Analogues of Pseudomonas aeruginosa signalling molecules to tackle infections'
O. Muimhneachain E,Reen, F. J.,O'Gara, F.,McGlacken, G. P. (2017) 'Analogues of Pseudomonas aeruginosa signalling molecules to tackle infections'. Org Biomol Chem,   [DOI] [Details]
(2017)'Direct and Rapid Electrochemical Detection of Pseudomonas aeruginosa Quorum Signaling Molecules in Bacterial Cultures and Cystic Fibrosis Sputum Samples through Cationic Surfactant-Assisted Membrane Disruption'
Buzid, Alyah; Reen, F. Jerry; Langsi, Victor K.; Muimhneacháin, Eoin Ó; O'Gara, Fergal; McGlacken, Gerard P.; Luong, John H. T.; Glennon, Jeremy D. (2017) 'Direct and Rapid Electrochemical Detection of Pseudomonas aeruginosa Quorum Signaling Molecules in Bacterial Cultures and Cystic Fibrosis Sputum Samples through Cationic Surfactant-Assisted Membrane Disruption'. ChemElectroChem,   [DOI] [CORA Link] [Details]
(2017)'Disruption of N-acyl-homoserine lactone-specific signalling and virulence in clinical pathogens by marine sponge bacteria'
Gutierrez-Barranquero, J. A.,Reen, F. J.,Parages, M. L.,McCarthy, R.,Dobson, A. D. W.,O'Gara, F. (2017) 'Disruption of N-acyl-homoserine lactone-specific signalling and virulence in clinical pathogens by marine sponge bacteria'. Microb Biotechnol,   [DOI] [Details]
(2017)'The requirements at the C-3 position of alkylquinolones for signalling in Pseudomonas aeruginosa'
Shanahan, R.,Reen, F. J.,Cano, R.,O'Gara, F.,McGlacken, G. P. (2017) 'The requirements at the C-3 position of alkylquinolones for signalling in Pseudomonas aeruginosa'. Org Biomol Chem, 15 (2):306-310   [DOI] [Details]
(2016)'Bile acids destabilise HIF-1alpha and promote anti-tumour phenotypes in cancer cell models'
Phelan, J. P.,Reen, F. J.,Dunphy, N.,O'Connor, R.,O'Gara, F. (2016) 'Bile acids destabilise HIF-1alpha and promote anti-tumour phenotypes in cancer cell models'. BMC Cancer, 16   [DOI] [Details]
(2016)'Harnessing bacterial signals for suppression of biofilm formation in the nosocomial fungal pathogen Aspergillus fumigatus'
Reen, F. Jerry; Phelan,John P.; Woods, David F.; Shanahan, Rachel; Cano, Rafael; Clarke, Sarah; McGlacken, Gerard P.; O’Gara, Fergal (2016) 'Harnessing bacterial signals for suppression of biofilm formation in the nosocomial fungal pathogen Aspergillus fumigatus'. Frontiers In Microbiology, 7 (2074) [DOI] [CORA Link] [Details]
(2016)'Dissecting the regulation of bile-induced biofilm formation in Staphylococcus aureus'
Ulluwishewa, D.,Wang, L.,Pereira, C.,Flynn, S.,Cain, E.,Stick, S.,Reen, F. J.,Ramsay, J. P.,O'Gara, F. (2016) 'Dissecting the regulation of bile-induced biofilm formation in Staphylococcus aureus'. Microbiology, 162 (8):1398-406   [DOI] [Details]
(2016)'Molecular Signature of Pseudomonas aeruginosa with Simultaneous Nanomolar Detection of Quorum Sensing Signaling Molecules at a Boron-Doped Diamond Electrode'
Buzid, A.,Shang, F.,Reen, F. J.,Muimhneachain, E. O.,Clarke, S. L.,Zhou, L.,Luong, J. H.,O'Gara, F.,McGlacken, G. P.,Glennon, J. D. (2016) 'Molecular Signature of Pseudomonas aeruginosa with Simultaneous Nanomolar Detection of Quorum Sensing Signaling Molecules at a Boron-Doped Diamond Electrode'. Sci Rep, 6   [DOI] [Details]
(2016)'Integrated (Meta) Genomic and Synthetic Biology Approaches to Develop New Biocatalysts'
Parages, M. L.,Gutierrez-Barranquero, J. A.,Reen, F. J.,Dobson, A. D.,O'Gara, F. (2016) 'Integrated (Meta) Genomic and Synthetic Biology Approaches to Develop New Biocatalysts'. Mar Drugs, 14 (3)   [DOI] [Details]
(2016)'Is There Potential for Repurposing Statins as Novel Antimicrobials?'
Hennessy, E.,Adams, C.,Reen, F. J.,O'Gara, F. (2016) 'Is There Potential for Repurposing Statins as Novel Antimicrobials?'. Antimicrob Agents Chemother, 60 (9):5111-21   [DOI] [Details]
(2016)'Synthesis and electrochemical detection of a thiazolyl-indole natural product isolated from the nosocomial pathogen Pseudomonas aeruginosa'
Buzid, A.,Muimhneachain, E. O.,Reen, F. J.,Hayes, P. E.,Pardo, L. M.,Shang, F.,O'Gara, F.,Sperry, J.,Luong, J. H.,Glennon, J. D.,McGlacken, G. P. (2016) 'Synthesis and electrochemical detection of a thiazolyl-indole natural product isolated from the nosocomial pathogen Pseudomonas aeruginosa'. Anal Bioanal Chem, 408 (23):6361-7   [DOI] [Details]
(2016)'Bile signalling promotes chronic respiratory infections and antibiotic tolerance'
Reen, F. J.,Flynn, S.,Woods, D. F.,Dunphy, N.,Chroinin, M. N.,Mullane, D.,Stick, S.,Adams, C.,O'Gara, F. (2016) 'Bile signalling promotes chronic respiratory infections and antibiotic tolerance'. Sci Rep, 6   [DOI] [Details]
(2016)'Exploiting Interkingdom Interactions for Development of Small-Molecule Inhibitors of Candida albicans Biofilm Formation'
Reen, F. J.,Phelan, J. P.,Gallagher, L.,Woods, D. F.,Shanahan, R. M.,Cano, R.,O. Muimhneachain E,McGlacken, G. P.,O'Gara, F. (2016) 'Exploiting Interkingdom Interactions for Development of Small-Molecule Inhibitors of Candida albicans Biofilm Formation'. Antimicrob Agents Chemother, 60 (10):5894-905   [DOI] [Details]
(2016)'Comparative Genomic Analysis Reveals a Diverse Repertoire of Genes Involved in Prokaryote-Eukaryote Interactions within the Pseudovibrio Genus'
Romano, S.,Fernandez-Guerra, A.,Reen, F. J.,Glockner, F. O.,Crowley, S. P.,O'Sullivan, O.,Cotter, P. D.,Adams, C.,Dobson, A. D.,O'Gara, F. (2016) 'Comparative Genomic Analysis Reveals a Diverse Repertoire of Genes Involved in Prokaryote-Eukaryote Interactions within the Pseudovibrio Genus'. Front Microbiol, 7   [DOI] [Details]
(2016)'Determining the Influence of Small Molecules on Hypoxic Prostate Cancer Cell (DU-145) Viability Using Automated Cell Counting and a Cell Harvesting Protocol'
Phelan, J.P. ,Reen, F.J. ,O’Gara, F (2016) 'Determining the Influence of Small Molecules on Hypoxic Prostate Cancer Cell (DU-145) Viability Using Automated Cell Counting and a Cell Harvesting Protocol'. Bio-Protocol, 6 (22) [Details]
(2015)'Emerging Concepts promising New Horizons for Marine Biodiscovery and Synthetic Biology'
Reen, F.J., Gutierrez-Barranquero, J., Adams, C. and O'Gara, F. (2015) 'Emerging Concepts promising New Horizons for Marine Biodiscovery and Synthetic Biology'. Marine Drugs, 13 (5):2924-2954 [DOI] [Details]
(2015)'Deciphering the role of coumarin as a novel quorum sensing inhibitor suppressing virulence phenotypes in bacterial pathogens'
Gutierrez-Barranquero, J.A., Reen, F.J., McCarthy, R.R. and O’Gara, F. (2015) 'Deciphering the role of coumarin as a novel quorum sensing inhibitor suppressing virulence phenotypes in bacterial pathogens'. Applied Microbiology and Biotechnology, :3303-3316 [DOI] [Details]
(2015)'The Sound of Silence: Activating Silent Biosynthetic Gene Clusters in Marine Microorganisms'
Reen, F. J.,Romano, S.,Dobson, A. D.,O'Gara, F. (2015) 'The Sound of Silence: Activating Silent Biosynthetic Gene Clusters in Marine Microorganisms'. Mar Drugs, 13 (8):4754-83   [DOI] [Details]
(2015)'A structure activity-relationship study of the bacterial signal molecule HHQ reveals swarming motility inhibition in Bacillus atrophaeus'
Reen, F. J.,Shanahan, R.,Cano, R.,O'Gara, F.,McGlacken, G. P. (2015) 'A structure activity-relationship study of the bacterial signal molecule HHQ reveals swarming motility inhibition in Bacillus atrophaeus'. Org Biomol Chem, 13 (19):5537-41   [DOI] [Details]
(2015)'Minimum Information about a Biosynthetic Gene cluster'
Medema, M. H.,Kottmann, R.,Yilmaz, P.,Cummings, M.,Biggins, J. B.,Blin, K.,de Bruijn, I.,Chooi, Y. H.,Claesen, J.,Coates, R. C.,Cruz-Morales, P.,Duddela, S.,Dusterhus, S.,Edwards, D. J.,Fewer, D. P.,Garg, N.,Geiger, C.,Gomez-Escribano, J. P.,Greule, A.,Hadjithomas, M.,Haines, A. S.,Helfrich, E. J.,Hillwig, M. L.,Ishida, K.,Jones, A. C.,Jones, C. S.,Jungmann, K.,Kegler, C.,Kim, H. U.,Kotter, P.,Krug, D.,Masschelein, J.,Melnik, A. V.,Mantovani, S. M.,Monroe, E. A.,Moore, M.,Moss, N.,Nutzmann, H. W.,Pan, G.,Pati, A.,Petras, D.,Reen, F. J.,Rosconi, F.,Rui, Z.,Tian, Z.,Tobias, N. J.,Tsunematsu, Y.,Wiemann, P.,Wyckoff, E.,Yan, X.,Yim, G.,Yu, F.,Xie, Y.,Aigle, B.,Apel, A. K.,Balibar, C. J.,Balskus, E. P.,Barona-Gomez, F.,Bechthold, A.,Bode, H. B.,Borriss, R.,Brady, S. F.,Brakhage, A. A.,Caffrey, (2015) 'Minimum Information about a Biosynthetic Gene cluster'. Nat Chem Biol, 11 (9):625-31   [DOI] [Details]
(2014)'Tle Distribution and Diversity in Metagenomic Datasets Reveals Niche Specialisation'
Egan, F., Reen, F.J. and O'Gara, F. (2014) 'Tle Distribution and Diversity in Metagenomic Datasets Reveals Niche Specialisation'. [Details]
(2014)'Bile acids repress hypoxia-inducible factor-1 (HIF-1) signaling and modulate the airway immune response'
Legendre, C., Mooij, M.J., Woods, D., Adams, C., Reen, F.J., and O’Gara, F. (2014) 'Bile acids repress hypoxia-inducible factor-1 (HIF-1) signaling and modulate the airway immune response'. Infection And Immunityinfection And Immunity, 82 (9) [Details]
(2014)'Aspirated bile: a major host trigger modulating respiratory pathogen colonisation in cystic fibrosis patients'
Reen, F. J.,Woods, D. F.,Mooij, M. J.,Chroinin, M. N.,Mullane, D.,Zhou, L.,Quille, J.,Fitzpatrick, D.,Glennon, J. D.,McGlacken, G. P.,Adams, C.,O'Gara, F. (2014) 'Aspirated bile: a major host trigger modulating respiratory pathogen colonisation in cystic fibrosis patients'. Eur J Clin Microbiol Infect Dis, 33 (10):1763-71   [DOI] [Details]
(2014)'Inhibition of co-colonising cystic fibrosis-associated pathogens by Pseudomonas aeruginosa and Burkholderia multivorans'
Costello, A., Reen, F.J., O’Gara, F., Callaghan, M., McClean, S. (2014) 'Inhibition of co-colonising cystic fibrosis-associated pathogens by Pseudomonas aeruginosa and Burkholderia multivorans'. Microbiology, 160 :1474-1487 [Details]
(2014)'Characterisation of non-autoinducing tropodithietic Acid (TDA) production from marine sponge Pseudovibrio species'
Harrington, C.,Reen, F. J.,Mooij, M. J.,Stewart, F. A.,Chabot, J. B.,Guerra, A. F.,Glockner, F. O.,Nielsen, K. F.,Gram, L.,Dobson, A. D.,Adams, C.,O'Gara, F. (2014) 'Characterisation of non-autoinducing tropodithietic Acid (TDA) production from marine sponge Pseudovibrio species'. Mar Drugs, 12 (12):5960-78   [DOI] [Details]
(2014)'A new regulator of pathogenicity (bvlR) is required for full virulence and tight microcolony formation in Pseudomonas aeruginosa'
McCarthy R.R., Mooij, M.J., Reen, F.J., Lesouhaitier, O., and O'Gara, F. (2014) 'A new regulator of pathogenicity (bvlR) is required for full virulence and tight microcolony formation in Pseudomonas aeruginosa'. Microbiology, 160 :1488-1500 [DOI] [Details]
(2014)'One step preparation and electrochemical analysis of IQS, a cell-cell communication signal in the nosocomial pathogen Pseudomonas aeruginosa'
Shang F, Muimhneacháin EÓ, Reen FJ, Buzid A, O'Gara F, Luong JH, Glennon JD, McGlacken GP (2014) 'One step preparation and electrochemical analysis of IQS, a cell-cell communication signal in the nosocomial pathogen Pseudomonas aeruginosa'. Bioorganic and Medicinal Chemistry Letters, 24 (19):4703-4707 [DOI] [Details]
(2013)'Statins inhibit in vitro virulence phenotypes of Pseudomonas aeruginosa'
Hennessy, E.,Mooij, M. J.,Legendre, C.,Reen, F. J.,O'Callaghan, J.,Adams, C.,O'Gara, F. (2013) 'Statins inhibit in vitro virulence phenotypes of Pseudomonas aeruginosa'. J Antibiot (Tokyo), 66 (2):99-101   [DOI] [Details]
(2013)'A non-classical LysR-type transcriptional regulator PA2206 is required for an effective oxidative stress response in Pseudomonas aeruginosa'
Reen, F. J.,Haynes, J. M.,Mooij, M. J.,O'Gara, F. (2013) 'A non-classical LysR-type transcriptional regulator PA2206 is required for an effective oxidative stress response in Pseudomonas aeruginosa'. PLoS One, 8 (1)   [DOI] [Details]
(2013)'Molecular evolution of LysR-type transcriptional regulation in Pseudomonas aeruginosa'
Reen, F. J.,Barret, M.,Fargier, E.,O'Muinneachain, M.,O'Gara, F. (2013) 'Molecular evolution of LysR-type transcriptional regulation in Pseudomonas aeruginosa'. Mol Phylogenet Evol, 66 (3):1041-9   [DOI] [Details]
(2012)'Structure-function analysis of the C-3 position in analogues of microbial behavioural modulators HHQ and PQS'
Reen, F. J.,Clarke, S. L.,Legendre, C.,McSweeney, C. M.,Eccles, K. S.,Lawrence, S. E.,O'Gara, F.,McGlacken, G. P. (2012) 'Structure-function analysis of the C-3 position in analogues of microbial behavioural modulators HHQ and PQS'. Org Biomol Chem, 10 (44):8903-10   [DOI] [Details]
(2012)'Structure–function analysis of the C-3 position in analogues of microbial behavioural modulators HHQ and PQS'
Reen, F. Jerry; Clarke, Sarah L.; Legendre, Claire; McSweeney, Christina M.; Eccles, Kevin S.; Lawrence, Simon E.; O'Gara, Fergal; McGlacken, Gerard P (2012) 'Structure–function analysis of the C-3 position in analogues of microbial behavioural modulators HHQ and PQS'. Organic and Biomolecular Chemistry, 10 (44):8903-8910   [Details]
(2012)'Pseudomonas aeruginosa Alkyl quinolones repress hypoxia-inducible factor 1 (HIF-1) signaling through HIF-1alpha degradation'
Legendre, C.,Reen, F. J.,Mooij, M. J.,McGlacken, G. P.,Adams, C.,O'Gara, F. (2012) 'Pseudomonas aeruginosa Alkyl quinolones repress hypoxia-inducible factor 1 (HIF-1) signaling through HIF-1alpha degradation'. Infect Immun, 80 (11):3985-92   [DOI] [Details]
(2012)'Analysis of Pseudomonas quinolone signal and other bacterial signalling molecules using capillaries coated with highly charged polyelectrolyte monolayers and boron doped diamond electrode'
Zhou, L.,Reen, F. J.,O'Gara, F.,McSweeney, C. M.,Clarke, S. L.,Glennon, J. D.,Luong, J. H.,McGlacken, G. P. (2012) 'Analysis of Pseudomonas quinolone signal and other bacterial signalling molecules using capillaries coated with highly charged polyelectrolyte monolayers and boron doped diamond electrode'. J Chromatogr A, 1251 :169-75   [DOI] [Details]
(2012)'Analysis of pseudomonas quinolone signal and other bacterial signalling molecules using capillaries coated with highly charged polyelectrolyte monolayers and boron doped diamond electrode'
Zhou, Lin; Reen, F. Jerry; O'Gara, Fergal; McSweeney, Christina M.; Clarke, Sarah L.; Glennon, Jeremy D.; Luong, John H. T.; McGlacken, Gerard P. (2012) 'Analysis of pseudomonas quinolone signal and other bacterial signalling molecules using capillaries coated with highly charged polyelectrolyte monolayers and boron doped diamond electrode'. Journal of Chromatography A, 1251 :169-175   [Details]
(2012)'A novel host-responsive sensor mediates virulence and type III secretion during Pseudomonas aeruginosa-host cell interactions'
O'Callaghan, J.,Reen, F. J.,Adams, C.,Casey, P. G.,Gahan, C. G.,O'Gara, F. (2012) 'A novel host-responsive sensor mediates virulence and type III secretion during Pseudomonas aeruginosa-host cell interactions'. Microbiology, 158 (Pt 4):1057-70   [DOI] [Details]
(2012)'Respiratory pathogens adopt a chronic lifestyle in response to bile'
Reen, F. J.,Woods, D. F.,Mooij, M. J.,Adams, C.,O'Gara, F. (2012) 'Respiratory pathogens adopt a chronic lifestyle in response to bile'. PLoS One, 7 (9)   [DOI] [Details]
(2011)'Low oxygen induces the type III secretion system in Pseudomonas aeruginosa via modulation of the small RNAs rsmZ and rsmY'
O'Callaghan, J.,Reen, F. J.,Adams, C.,O'Gara, F. (2011) 'Low oxygen induces the type III secretion system in Pseudomonas aeruginosa via modulation of the small RNAs rsmZ and rsmY'. Microbiology, 157 (Pt 12):3417-28   [DOI] [Details]
(2011)'The Pseudomonas quinolone signal (PQS), and its precursor HHQ, modulate interspecies and interkingdom behaviour'
Reen, F.J., Mooij, M.J., Holcombe, L.J., McSweeney, C.M., McGlacken, G.P., Morrissey, J.P., and O'Gara, F.; (2011) 'The Pseudomonas quinolone signal (PQS), and its precursor HHQ, modulate interspecies and interkingdom behaviour'. FEMS Microbiol Ecol, 77 (2):413-428   [DOI] [Details]
(2011)'The Pseudomonas quinolone signal (PQS), and its precursor HHQ, modulate interspecies and interkingdom behaviour'
Reen, F. J.,Mooij, M. J.,Holcombe, L. J.,McSweeney, C. M.,McGlacken, G. P.,Morrissey, J. P.,O'Gara, F. (2011) 'The Pseudomonas quinolone signal (PQS), and its precursor HHQ, modulate interspecies and interkingdom behaviour'. FEMS Microbiol Ecol, 77 (2):413-28   [DOI] [Details]
(2011)'Detection of the Pseudomonas Quinolone Signal (PQS) by cyclic voltammetry and amperometry using a boron doped diamond electrode'
Zhou, L.,Glennon, J. D.,Luong, J. H.,Reen, F. J.,O'Gara, F.,McSweeney, C.,McGlacken, G. P. (2011) 'Detection of the Pseudomonas Quinolone Signal (PQS) by cyclic voltammetry and amperometry using a boron doped diamond electrode'. Chem Commun (Camb), 47 (37):10347-9   [DOI] [Details]
(2011)'Low oxygen induces the T3SS in Pseudomonas aeruginosa via modulation of the small RNAs, rsmZ and rsmY'
O’Callaghan, J., Reen, F.J., Adams, C., and O'Gara, F. (2011) 'Low oxygen induces the T3SS in Pseudomonas aeruginosa via modulation of the small RNAs, rsmZ and rsmY'. Microbiology, [DOI] [Details]
(2011)'Detection of the Pseudomonas Quinolone Signal (PQS) by cyclic voltammetry and amperometry using a boron doped diamond electrode'
Zhou, L., Glennon, J.D., Luong, J.H.T., Reen, F.J., O'Gara, F., McSweeney, C., and McGlacken, G.P.; (2011) 'Detection of the Pseudomonas Quinolone Signal (PQS) by cyclic voltammetry and amperometry using a boron doped diamond electrode'. Chemical Communications, 47 (37):10347-10349 [DOI] [Details]
(2010)'Synthesis of 3-halo-analogues of HHQ, subsequent cross-coupling and first crystal structure of Pseudomonas Quinolone Signal, PQS'
McGlacken, Gerard P., McSweeney, Christina M., O'Brien, Timothy, Lawrence, Simon E., Elcoate, Curtis J., Reen, F. Jerry, and O'Gara, Fergal; (2010) 'Synthesis of 3-halo-analogues of HHQ, subsequent cross-coupling and first crystal structure of Pseudomonas Quinolone Signal, PQS'. Tetrahedron Letters, 51 :5919-5921   [DOI] [Details]
(2009)'Subinhibitory concentrations of the cationic antimicrobial peptide colistin induce the pseudomonas quinolone signal in Pseudomonas aeruginosa'
Cummins, J.,Reen, F. J.,Baysse, C.,Mooij, M. J.,O'Gara, F. (2009) 'Subinhibitory concentrations of the cationic antimicrobial peptide colistin induce the pseudomonas quinolone signal in Pseudomonas aeruginosa'. Microbiology, 155 (Pt 9):2826-37   [DOI] [Details]
(2009)'Sensitive and rapid molecular detection assays for Salmonella enterica serovars Typhimurium and Heidelberg'
McCarthy, N.,Reen, F. J.,Buckley, J. F.,Frye, J. G.,Boyd, E. F.,Gilroy, D. (2009) 'Sensitive and rapid molecular detection assays for Salmonella enterica serovars Typhimurium and Heidelberg'. J Food Prot, 72 (11):2350-7   [Details]
(2008)'Rapid multiplex PCR and real-time TaqMan PCR assays for detection of Salmonella enterica and the highly virulent serovars Choleraesuis and Paratyphi C'
Woods, D. F.,Reen, F. J.,Gilroy, D.,Buckley, J.,Frye, J. G.,Boyd, E. F. (2008) 'Rapid multiplex PCR and real-time TaqMan PCR assays for detection of Salmonella enterica and the highly virulent serovars Choleraesuis and Paratyphi C'. J Clin Microbiol, 46 (12):4018-22   [DOI] [Details]
(2006)'The genomic code: inferring Vibrionaceae niche specialization'
Reen, F. J.,Almagro-Moreno, S.,Ussery, D.,Boyd, E. F. (2006) 'The genomic code: inferring Vibrionaceae niche specialization'. Nat Rev Microbiol, 4 (9):697-704   [DOI] [Details]
(2006)'Genomic island identification in Vibrio vulnificus reveals significant genome plasticity in this human pathogen'
Quirke, A. M.,Reen, F. J.,Claesson, M. J.,Boyd, E. F. (2006) 'Genomic island identification in Vibrio vulnificus reveals significant genome plasticity in this human pathogen'. Bioinformatics, 22 (8):905-10   [DOI] [Details]
(2006)'Four genomic islands that mark post-1995 pandemic Vibrio parahaemolyticus isolates'
Hurley, C. C.,Quirke, A.,Reen, F. J.,Boyd, E. F. (2006) 'Four genomic islands that mark post-1995 pandemic Vibrio parahaemolyticus isolates'. BMC Genomics, 7   [DOI] [Details]
(2005)'Genomic comparisons of Salmonella enterica serovar Dublin, Agona, and Typhimurium strains recently isolated from milk filters and bovine samples from Ireland, using a Salmonella microarray'
Reen, F. J.,Boyd, E. F.,Porwollik, S.,Murphy, B. P.,Gilroy, D.,Fanning, S.,McClelland, M. (2005) 'Genomic comparisons of Salmonella enterica serovar Dublin, Agona, and Typhimurium strains recently isolated from milk filters and bovine samples from Ireland, using a Salmonella microarray'. Appl Environ Microbiol, 71 (3):1616-25   [DOI] [Details]
(2005)'Molecular typing of epidemic and nonepidemic Vibrio cholerae isolates and differentiation of V. cholerae and V. mimicus isolates by PCR-single-strand conformation polymorphism analysis'
Reen, F. J.,Boyd, E. F. (2005) 'Molecular typing of epidemic and nonepidemic Vibrio cholerae isolates and differentiation of V. cholerae and V. mimicus isolates by PCR-single-strand conformation polymorphism analysis'. J Appl Microbiol, 98 (3):544-55   [DOI] [Details]
(2004)'The {Vibrio} seventh pandemic island-II is a 26.9 kb genomic island present in {Vibrio cholerae} El Tor and O139 serogroup isolates that shows homology to a 43.4 kb genomic island in {V. vulnificus}'
O'Shea, Y.A., Finnan, S., Reen, F.J., Morrissey, J.P., O'Gara, F., and Boyd, E.F.; (2004) 'The {Vibrio} seventh pandemic island-II is a 26.9 kb genomic island present in {Vibrio cholerae} El Tor and O139 serogroup isolates that shows homology to a 43.4 kb genomic island in {V. vulnificus}'. Microbiology, 150.12 (*):4053-4063 [Details]
(2004)'Evolutionary genetic analysis of the emergence of epidemic Vibrio cholerae isolates on the basis of comparative nucleotide sequence analysis and multilocus virulence gene profiles'
O'Shea, Y. A.,Reen, F. J.,Quirke, A. M.,Boyd, E. F. (2004) 'Evolutionary genetic analysis of the emergence of epidemic Vibrio cholerae isolates on the basis of comparative nucleotide sequence analysis and multilocus virulence gene profiles'. J Clin Microbiol, 42 (10):4657-71   [DOI] [Details]
(2003)'Molecular characterisation and expression analysis of the first hemicellulase gene (bxl1) encoding beta-xylosidase from the thermophilic fungus Talaromyces emersonii'
Reen, F. J.,Murray, P. G.,Tuohy, M. G. (2003) 'Molecular characterisation and expression analysis of the first hemicellulase gene (bxl1) encoding beta-xylosidase from the thermophilic fungus Talaromyces emersonii'. Biochem Biophys Res Commun, 305 (3):579-85   [Details]

Professional Activities

Honours and Awards

 YearTitleAwarding Body
2016Purdy-Lucey UCC Life Sciences Invention of the Year 2015 Office of Technology Transfer, UCC
2015'You in Youtube’ Outreach Competition School of Microbiology, UCC
2012Best Poster Exhibition Royal Irish Academy
2011National Researcher of the Year, Silver Medal Roche
2011BioSciences Researcher of the Year, Gold Medal Roche
2011Technology Start-Up Entrepreneurship Programme SFI and DCU Ryan Academy

Professional Associations

 AssociationFunctionFrom / To
Irish Research Council for Science Engineering and Technology PostDoctoral Fellow01-OCT-04 / 01-MAR-07
Institute of Leadership Management Scholar05-OCT-15 / 31-DEC-16

Patents

 Patent NumberTitleGranted
1513614.6, UCCSmall molecules for biofilm prevention 31-JUL-16

Education

 YearInstitutionQualificationSubject
2013Confucius Centre, UCC Certificate of MeritBeginners Chinese
2007UCC CertificateIrish and UK Accreditation for Animal Research
2017Wellcome Trust and Open University CertificateInternational Funders Award
2014NUI-UCC Postgraduate CertificateTeaching and Learning in Higher Education
2011DCU Ryan Academy Certificate of MeritGet Started Technology Venture Entrepreneurship Programme
2016Institute of Leadership Management and UCC CertificateProfessional Skills for Research Leaders
2015NUI-UCC Postgraduate DiplomaTeaching and Learning in Higher Education

Languages

 LanguageReadingWritingSpeaking
Gaeilge FluentFluentFluent
English FluentFluentFluent

Outreach Activities

 Description

Hosted BT Young Scientist students dealing with aspects of biofilm formation

Member of Enterprise Ireland focus group on Research Commercialisation

Deliver a science show at local Gaelscoil 'as gaeilge'

Journal Activities

 JournalRoleTo / From
Fems Microbiology Letters Referee-
Canadian Journal Of Microbiology Referee-
Antimicrobial Agents And Chemotherapy Referee-
Frontiers In Microbiology Referee-
Isme Journal Referee-
Journal Of Medical Microbiology Referee-
Plos One Referee-
Journal Of Antimicrobial Chemotherapy Referee-

Other Activities

 Description

Moderator of Expert Panel on Nagoya Protocol, Marine Microbiome Discovery and Innovation, Industry Conference, Berlin, Germany 2016

Contact details

Search profiles by name

Search profiles by topic

School of Microbiology

Scoil na Micribhitheolaíochta

Microbiology Office, Room FSB452 4th Floor Food Science & Technology Building University College Cork, Cork

Top