Senior Lecturer
Microbiology
University College Cork
Cork
Ireland

T: +353-21-490-3000
F: +353 21 490 1363
E: C.Gahan@ucc.ie
W: http://www.ucc.ie/
Senior Lecturer
Microbiology
School of Microbiology
& School of Pharmacy
University College Cork

T: +353 21 490 1363
F: +353 21 490 3101
E: C.Gahan@ucc.ie

Overview

Dr. Cormac Gahan graduated in 1996 with a PhD in Immunology and Microbiology from University College Cork. He has since published 114 peer-reviewed articles and book chapters in journals including PNAS, Molecular Microbiology, Infection and Immunity, Vaccine and Journal of Bacteriology. His current h-index is 43 (i10-index is 78) with total career citations of 5685

Recent work has examined the use of live L. monocytogenes and L. lactis vectors as gene and protein delivery platforms for novel vaccination and therapeutic approaches. This work has been carried out in collaboration with Dr. Mark Tangney at the Cork Cancer Research Centre and Dr. Brendan Griffin in the School of Pharmacy, UCC. Dr. Gahan led the Infectious Disease programme with Prof. Colin Hill within the Alimentary Pharmabiotic Centre (Globe iconhttp://apc.ucc.ie ) from 2003-2013 and now leads the Bile Research Group within the APC with Dr. Susan Joyce. He is funded by further grants from Science Foundation Ireland, the Health Research Board and the EU (FP7 and H2020).

Dr. Gahan is currently on the Editorial Board of the Journal of Pathogens andApplied and Environmental Microbiology and was on the editorial board of Journal of Applied Microbiology & Letters in Applied Microbiology from 2004-2010.  Dr. Gahan directed the SFI funded UREKA programme entitled Microbe-Host Interactions that provided laboratory training for undergraduate students (Globe iconhttp://ureka.ucc.ie ) from 2006-2011.

 Academic Career

1986-1990: BSc

1990-1995: PhD Immunology & Microbiology

2011: PG Cert in TLHE

Additional Positions and Awards

1995-1998: Postdoctoral Researcher, Department of Microbiology, UCC

1998-2001: Health Research Board Postdoctoral Research Fellow, UCC

2001-2003: Principal Investigator, Listeria pathogenesis, UCC

2002-2004: Temporary Lecturer, Department of Microbiology, UCC

2004-Present: Faculty Appointment, School of Pharmacy & Department of Microbiology, UCC

2006: Enterprise Ireland International Collaboration Award to visit collaborators (Dr. Jonathan Hardy and Prof. Chris Contag) at Stanford University Medical School

2006-Present: Director of UREKA undergraduate research programme (Microbe-Host Interactions, UCC) funded by SFI

2005-Present: Member of editorial board of Journal of Applied Microbiology and Letters in Applied Microbiology

Teaching areas

Microbiology – an Introduction for Pharmacy Students (MB2444)Clinical Microbiology for Pharmacy Students (PF3444)Advanced Medical Microbiology (MB4007)Advanced Immunology (MB4009)Pharmaceutical Biotechnology (PF4109 & PF6205)Pharmaceutical Microbiology & Sterile Manufacturing (PF6203)

Research interests and expertise

Bile acids as mediators of host-microbe signalling in the gutDevelopment of live bacterial vaccine and DNA delivery vectorsUnderstanding microbial pathogenesis in gut pathogens (Listeria monocytogenes & Clostridium difficile)Culture-independent approaches to understanding the gut microbiota

Research Interests

Research Overview

My research group is dedicated to understanding the molecular interactions between bacteria and the host in the gastrointestinal tract. Our work has examined the pathogenesis of specific gut pathogens (in particular Listeria monocytogenes and Clostridium difficile) as well as the specific interactions that occur between gut commensals and the host organism. A complete understanding of the mechanisms governing host-pathogen interactions in the GI tract can be used to inform vaccine or DNA delivery strategies, to combat infections or to exploit the unique properties of these organisms as live vectors for the delivery of novel therapeutics. For example in collaboration with Dr. Mark Tangney at the Cork Cancer Research Centre we have recently exploited attenuated L. monocytogenes as a gene delivery vehicle for targeting tumour cells (van Pijkeren et al, 2010, Human Gene Therapy). In addition, benign L. lactis bacteria can be used to express a protein from L. monocytogenes that improves the ability of the organism to act as a vaccine delivery vector (in collaboration with Dr. Brendan Griffin; Bahey-el-din et al., 2008, Vaccine).

L. monocytogenes shares much in common with normal harmless bacteria that reside as commensals in the human GI tract. We have utilized culture-independent approaches (metagenomics) to examine one such activity (bile salt hydrolase (BSH)) that is abundant throughout the entire population of organisms in the GI tract (Jones et al., 2008, Proceedings of the National Academy of Sciences). More recent work in my group (with Dr. Susan Joyce) has demonstrated the significant impact exerted by bacterial BSH activity in the gut (Joyce et al. 2014, Proceedings of the National Academy of Sciences). The work demonstrates the potential for gut bacteria to significantly alter host physiological parameters (including immune function, lipid metabolism and circadian rhythm) by coordinating changes to host bile acid profiles. Ongoing work in our Bile Research Group is further examining the impact of microbially-altered bile acid profiles upon disease states using appropriate models.

Key Publications (*corresponding author):

MICROBIAL BILE ACID METABOLISM

Joyce SA, MacSharry J, Casey PG, Kinsella M, Murphy EF, Shanahan F, Hill C, Gahan CG*. 2014. Regulation of host weight gain and lipid metabolism by bacterial bile acid modification in the gut. Proc Natl Acad Sci U S A. 111(20):7421-6.

Pereira-Fantini PM, Lapthorne S, Joyce SA, Dellios NL, Wilson G, Fouhy F, Thomas SL, Scurr M, Hill C, Gahan CG, Cotter PD, Fuller PJ, Hardikar W, Bines JE. 2014. Altered FXR signaling is associated with bile acid dysmetabolism in short bowel syndrome-associated liver disease. J Hepatol. 61(5):1115-25

Joyce SA and Gahan CG*. 2014. The gut microbiota and the metabolic health of the host. Curr Opin Gastroenterol. 30(2):120-7

Dowd G, Joyce SA, Hill C, Gahan CG*. 2011. (From the cover) Investigation of the mechanisms by which Listeria monocytogenes grows in porcine gall bladder bile. Infection & Immunity. 79(1):369-79

Jones BV, Begley M, Hill C, Gahan CGM*, Marchesi JR. 2008. Functional and comparative metagenomic analysis of bile salt hydrolase activity in the human gut microbiome. Proc Natl Acad Sci U S A. 105(36):13580-5.

Begley M, CGM Gahan* and C Hill. 2005. The interaction between bacteria and bile. FEMS Microbiology Reviews. 29(4):625-51

BACTERIAL VACCINATION & TUMOUR TARGETING

van Pijkeren JP, Morrissey D, Cronin M, Rajendran S, O’Sullivan G, Gahan CG*, Tangney M. 2010. A novel Listeria monocytogenes-based system for cancer gene therapy. Human Gene Therapy. 21(4):405-16

Bahey-el-din M, Casey PG, Griffin BT, Gahan CG. 2010. Efficacy of a Lactococcus lactis delta-pyrG vaccine delivery platform expressing chromosomally integrated hly from Listeria monocytogenes. BioEngineered. 1(1):66-74.

Bahey-El-Din M, Casey PG, Griffin BT and CGM Gahan. 2008. Lactococcus lactis expressing Listeriolysin O (LLO) provides protection and specific CD8+ T cells against Listeria monocytogenes in the murine infection model. Vaccine. 26(41):5311-21.

MICROBIAL PATHOGENESIS

Cummins J, Casey PG, Joyce SA, Gahan CG*. 2013. A Mariner Transposon-Based Signature-Tagged Mutagenesis System for the Analysis of Oral Infection by Listeria monocytogenes. PLoS One. 8(9):e75437

Heuston S, Begley M, Davey MS, Eberl M, Casey PG, Hill C, Gahan CG. 2012. HmgR, a key enzyme in the mevalonate pathway for isoprenoid biosynthesis, is essential for growth of Listeria monocytogenes EGDe. Microbiology. 158(Pt 7):1684-93.

McLaughlin HP, Xiao Q, Rea RB, Pi H, Casey PG, Darby T, Charbit A, Sleator RD, Joyce SA, Cowart RE, Hill C, Klebba PE, Gahan CG*. 2012. A putative P-type ATPase required for virulence and resistance to haem toxicity in Listeria monocytogenes. Plos One ;7(2):e30928.

Joyce SA, Gahan CG*. 2010. The molecular pathogenesis of Listeria monocytogenes in the alternative model host Galleria mellonella. Microbiology. 156(Pt 11):3456-68.

Ryan S, Begley M, Gahan CGM* and Hill C. 2009. Molecular characterization of the arginine deiminase (ADI) system in Listeria monocytogenes: regulation and role in acid tolerance. Environmental Microbiology. 11(2):432-45.

Corr SC, Li Y, Riedel CU, O’Toole PW, Hill C, Gahan CGM. 2007. (From the cover) Bacteriocin production as a mechanism for the anti-infective activity of Lactobacillus salivarius UCC118. Proc. Natl. Acad. Sci. (USA). 104(18): 7617-7621.

RESEARCH FUNDING & GRANTS

Current:

EU FP7 Industry Academia Partnerships & Pathways grant. Co-ordinated and led by Dr. Mark Tangney, Cork Cancer Research Centre (CCRC) and with partners in Italy and Switzerland.

EU Horizon 2020 Initial training Network. 2014-2017. Co-ordinated and led by Dr. Pascal Piveteau, University of Dijon including partners from NUIGalway, University of Copenhagen and Wageningen University.

Health Research Board, Health Research Award. 2013-2016. Lead PI Dr. Cormac Gahan with co-PIs Dr. Susan Joyce and Prof Fergus Shanahan and collaborator Dr. Marcus Claesson.

Alimentary Pharmabiotic Centre (APC). SFI Centres Award. 2013-2018. Bile Acid Group (Targeted Project 4) led by Dr. Cormac Gahan and Dr. Susan Joyce.

Department of Agriculture & The Marine FIRM Programme. Dec 2012-2016. TransListeria: Translating fundamental research on Listeria monocytogenes for the benefit of a multi-sectoral ready-to-eat food industry. Project led by Dr. Kieran Jordan, Teagasc, Moorepark. Budget to UCC (Dr. Cormac Gahan) is €345,996

Expired:
• IRCSET Post-graduate Research Fellowship (to James Nolan), (2010-2013)
• SFI Research Frontiers Programme Grant, (2008-2011) Functional genetic analysis of Listeria monocytogenes infection of the GI tract 08/RFP/GEN1320
• SFI CSET , the Alimentary Pharmabiotic Centre, UCC, (2008-2013), co-leader of the Pathogenicity Programme (with Prof. Colin Hill) and one of 22 principal investigators associated with the scientific research programme. For details see http://apc.ucc.ie
• Microbe-Host Interactions UREKA Site for Undergraduate Research projects, (2009-2011), SFI. 09/UR/B1527. For details see http://ureka.ucc.ie
• SFI Research Frontiers Programme Grant ,‘ Listeria monocytogenes as a vector for cancer gene therapy', (2007-2008), co-leader with Dr. Mark Tangney (lead applicant)
• IRCSET Post-graduate Research Fellowship (to Sinead Heuston), (2006-2009) with Prof. Colin Hill (co-supervisor)
• IRCSET Post-graduate Research Fellowship (to Heather McLaughlin), (2006-2009) with Prof. Colin Hill (co-supervisor)
• TRAMWAYS: Transfer of knowledge in microbial signal transduction pathways and metagenomics', European Union, Marie-Curie Host Fellowships for the Transfer of Knowledge (TOK) Development Host Schemes, (2007-2009) with members of the Department of Microbiology (lead applicant is Prof. Alan Dobson).
• Exploitation of in vivo -induced antigen technology (IVIAT) in Clostridium difficile: a rational approach to vaccine development, HRB Research Project Grant , (2006-2009)
• RP/2006/23SFI Research Frontiers Programme Grant, (2005-2008) The influence of bile tolerance on the pathogenesis and immunogenicity of Listeria monocytogenes , 05/RFP/GEN022

Peer Reviewed Journals

YearPublication
(2014)'Listeria monocytogenes: survival and adaptation in the gastrointestinal tract'
Gahan CG, Hill C (2014) 'Listeria monocytogenes: survival and adaptation in the gastrointestinal tract'. Frontiers in cellular and infection microbiology, 4 [DOI] [Details]
(2014)'Regulation of host weight gain and lipid metabolism by bacterial bile acid modification in the gut'
Joyce, SA,MacSharry, J,Casey, PG,Kinsella, M,Murphy, EF,Shanahan, F,Hill, C,Gahan, CGM (2014) 'Regulation of host weight gain and lipid metabolism by bacterial bile acid modification in the gut'. Proceedings of The National Academy of Sciences of The United States of America, 111 :7421-7426 [DOI] [Details]
(2014)'Divergent Evolution of the Activity and Regulation of the Glutamate Decarboxylase Systems in Listeria monocytogenes EGD-e and 10403S: Roles in Virulence and Acid Tolerance'
Feehily C, Finnerty A, Casey PG, Hill C, Gahan CG, O'Byrne CP, Karatzas KA (2014) 'Divergent Evolution of the Activity and Regulation of the Glutamate Decarboxylase Systems in Listeria monocytogenes EGD-e and 10403S: Roles in Virulence and Acid Tolerance'. Plos One, 9 (11) [DOI] [Details]
(2014)'The gut microbiota and the metabolic health of the host'
Joyce SA, Gahan CG (2014) 'The gut microbiota and the metabolic health of the host'. Current opinion in gastroenterology, 30 (2):120-127 [DOI] [Details]
(2014)'Vaccination studies: detection of a Listeria monocytogenes-specific T cell immune response using the ELISPOT technique'
Bahey-El-Din M, Gahan CG (2014) 'Vaccination studies: detection of a Listeria monocytogenes-specific T cell immune response using the ELISPOT technique'. Methods in molecular biology (Clifton, N.J.), 1157 :263-274 [DOI] [Details]
(2014)'Two-tiered biological containment strategy for Lactococcus lactis-based vaccine or immunotherapy vectors'
Hanin A; Culligan EP; Casey PG; Bahey-El-Din M; Hill C; Gahan CG (2014) 'Two-tiered biological containment strategy for Lactococcus lactis-based vaccine or immunotherapy vectors'. Human Vaccines & Immunotherapeutics, [Details]
(2014)'Bacterial systems for gene delivery to systemic tumors'
Cummins J, Cronin M, van Pijkeren JP, Gahan CG, Tangney M (2014) 'Bacterial systems for gene delivery to systemic tumors'. Methods in molecular biology (Clifton, N.J.), 1141 :201-209 [DOI] [Details]
(2014)'Altered FXR signaling is associated with bile acid dysmetabolism in short bowel syndrome-associated liver disease'
Pereira-Fantini PM, Lapthorne S, Joyce SA, Dellios NL, Wilson G, Fouhy F, Thomas SL, Scurr M, Hill C, Gahan CG, Cotter PD, Fuller PJ, Hardikar W, Bines JE (2014) 'Altered FXR signaling is associated with bile acid dysmetabolism in short bowel syndrome-associated liver disease'. Journal of hepatology, [DOI] [Details]
(2013)'Virulence aspects of Listeria monocytogenes LO28 high pressure-resistant variants'
Van Boeijen IK; Casey PG; Hill C; Moezelaar R; Zwietering MH; Gahan CG; Abee T (2013) 'Virulence aspects of Listeria monocytogenes LO28 high pressure-resistant variants'. Microbial Pathogenesis, [Details]
(2013)'Mobile genetic elements of the human gastrointestinal tract: potential for spread of antibiotic resistance genes'
Broaders E, Gahan CG, Marchesi JR (2013) 'Mobile genetic elements of the human gastrointestinal tract: potential for spread of antibiotic resistance genes'. Gut microbes, 4 (4):271-280 [DOI] [Details]
(2013)'Influence of internalin A murinisation on host resistance to orally acquired listeriosis in mice'
Bergmann S, Beard PM, Pasche B, Lienenklaus S, Weiss S, Gahan CG, Schughart K, Lengeling A (2013) 'Influence of internalin A murinisation on host resistance to orally acquired listeriosis in mice'. BMC Microbiology, 13 [DOI] [Details]
(2013)'A Mariner Transposon-Based Signature-Tagged Mutagenesis System for the Analysis of Oral Infection by Listeria monocytogenes'
Cummins, J,Casey, PG,Joyce, SA,Gahan, CGM (2013) 'A Mariner Transposon-Based Signature-Tagged Mutagenesis System for the Analysis of Oral Infection by Listeria monocytogenes'. Plos One, 8 [DOI] [Details]
(2013)'A mutant in the Listeria monocytogenes Fur-regulated virulence locus (frvA) induces cellular immunity and confers protection against listeriosis in mice'
McLaughlin HP; Bahey-El-Din M; Casey PG; Hill C; Gahan CG (2013) 'A mutant in the Listeria monocytogenes Fur-regulated virulence locus (frvA) induces cellular immunity and confers protection against listeriosis in mice'. Journal of Medical Microbiology, [Details]
(2012)'Isoprenoid biosynthesis in bacterial pathogens'
Heuston S, Begley M, Gahan CG, Hill C (2012) 'Isoprenoid biosynthesis in bacterial pathogens'. Microbiology (Reading, England), 158 (Pt 6):1389-1401 [DOI] [Details]
(2012)'A putative P-type ATPase required for virulence and resistance to haem toxicity in Listeria monocytogenes'
McLaughlin HP; Xiao Q; Rea RB; Pi H; Casey PG; Darby T; Charbit A; Sleator RD; Joyce SA; Cowart RE; Hill C; Klebba PE; Gahan CG (2012) 'A putative P-type ATPase required for virulence and resistance to haem toxicity in Listeria monocytogenes'. Plos One, [Details]
(2012)'Investigation of the role of ZurR in the physiology and pathogenesis of Listeria monocytogenes'
Dowd, G.C. and Casey, P.G. and Begley, M. and Hill, C. and Gahan, C.G.M. (2012) 'Investigation of the role of ZurR in the physiology and pathogenesis of Listeria monocytogenes'. Fems Microbiology Letters, [Details]
(2012)'The bacterial lux reporter system: applications in bacterial localisation studies'
Gahan CG (2012) 'The bacterial lux reporter system: applications in bacterial localisation studies'. Current Gene Therapy, 12 (1):12-19 [Details]
(2012)'A novel host-responsive sensor mediates virulence and type III secretion during Pseudomonas aeruginosa-host cell interactions'
O'Callaghan J; Reen FJ; Adams C; Casey PG; Gahan CG; O'Gara F (2012) 'A novel host-responsive sensor mediates virulence and type III secretion during Pseudomonas aeruginosa-host cell interactions'. Microbiology, [Details]
(2012)'HmgR, a key enzyme in the mevalonate pathway for isoprenoid biosynthesis, is essential for growth of Listeria monocytogenes EGDe'
Heuston S; Begley M; Davey MS; Eberl M; Casey PG; Hill C; Gahan CG (2012) 'HmgR, a key enzyme in the mevalonate pathway for isoprenoid biosynthesis, is essential for growth of Listeria monocytogenes EGDe'. Microbiology, [Details]
(2012)'Signature tagged mutagenesis in the functional genetic analysis of gastrointestinal pathogens'
Cummins J, Gahan CG (2012) 'Signature tagged mutagenesis in the functional genetic analysis of gastrointestinal pathogens'. Gut, 3 (2):93-103 [DOI] [Details]
(2012)'Human Microbiota in Health and Disease'
De Vos W, Engstrand L, Drago L, Reid G, Schauber J, Hay R, Mendling W, Schaller M, Spiller R, Gahan CG, Rowland I. (2012) 'Human Microbiota in Health and Disease'. Biofeedback and self-regulation, 5 (5):100-115 [Details]
(2012)'High Resolution In Vivo Bioluminescent Imaging For The Study Of Bacterial Tumour Targeting'
Cronin, M. C.,Akin, A. R.,Collins, S. A.,Meganck, J.,Kim, J-B.,Baban, C. K.,Joyce, S. A.,van Dam, G. M.,Zhang, N.,van Sinderen, D.,O'Sullivan, G. C.,Kasahara, N.,Gahan, C. G.,Francis, K. P.,Tangney, M. (2012) 'High Resolution In Vivo Bioluminescent Imaging For The Study Of Bacterial Tumour Targeting'. PLoS One, 7 (11) [Full Text] [Details]
(2012)'A mutant in the Listeria monocytogenes Fur-regulated virulence locus (frvA) induces cellular immunity and confers protection against listeriosis in mice'
McLaughlin HP, Bahey-El-Din M, Casey PG, Hill C, Gahan CG (2012) 'A mutant in the Listeria monocytogenes Fur-regulated virulence locus (frvA) induces cellular immunity and confers protection against listeriosis in mice'. Journal of Medical Microbiology, [DOI] [Details]
(2011)'The impact of iron on Listeria monocytogenes; inside and outside the host'
McLaughlin HP, Hill C, Gahan CG; (2011) 'The impact of iron on Listeria monocytogenes; inside and outside the host'. Current opinion in biotechnology, 22 (2):194-199 [DOI] [Details]
(2011)'Lactococcus lactis based vaccines: current status and future perspectives'
Bahey-el-din M and Gahan CG (2011) 'Lactococcus lactis based vaccines: current status and future perspectives'. Human Vaccines, 7 (1):106-109 [Details]
(2011)'Human neutrophil clearance of bacterial pathogens triggers anti-microbial gamma\delta T cell responses in early infection'
Davey, M.S. and Lin, C.Y. and Roberts, G.W. and Heuston, S. and Brown, A.C. and Chess, J.A. and Toleman, M.A. and Gahan, C.G.M. and Hill, C. and Parish, T. and others (2011) 'Human neutrophil clearance of bacterial pathogens triggers anti-microbial gamma\delta T cell responses in early infection'. Plos Pathogens, 7 (5) [Full Text] [Details]
(2011)'Investigation of the Mechanisms by Which Listeria monocytogenes Grows in Porcine Gallbladder Bile'
Dowd, G.C. and Joyce, S.A. and Hill, C. and Gahan, C.G.M. (2011) 'Investigation of the Mechanisms by Which Listeria monocytogenes Grows in Porcine Gallbladder Bile'. Infection and immunity, 79 (1) [Details]
(2011)'E. coli O104: H4: Social media and the characterisation of an emerging pathogen'
Casey, P.G. and Hill, C. and Gahan, CG (2011) 'E. coli O104: H4: Social media and the characterisation of an emerging pathogen'. Bioengineered bugs, 2 (4) [Details]
(2011)'Factors affecting survival of Listeria monocytogenes and Listeria innocua in soil samples'
McLaughlin, HP,Casey, PG,Cotter, J,Gahan, CGM,Hill, C (2011) 'Factors affecting survival of Listeria monocytogenes and Listeria innocua in soil samples'. Archives of Microbiology, 193 :775-785 [DOI] [Details]
(2010)'Lactococcus lactis as a cell factory for delivery of therapeutic proteins'
Bahey-El-Din, M; Gahan, CG; Griffin, BT; (2010) 'Lactococcus lactis as a cell factory for delivery of therapeutic proteins'. Current Gene Therapy, 10 (1):34-45 [Details]
(2010)'Efficacy of a Lactococcus lactis ΔpyrG vaccine delivery platform expressing chromosomally integrated hly from Listeria monocytogenes'
Bahey-EL-Din, M; Caset, PG; Griffin, BT; Gahan, C; (2010) 'Efficacy of a Lactococcus lactis ΔpyrG vaccine delivery platform expressing chromosomally integrated hly from Listeria monocytogenes'. Bioengineered Bugs, 1 (1):66-74 Globe icon [Details]
(2010)'The truncated phage lysin CHAP(k) eliminates Staphylococcus aureus in the nares of mice'
Fenton M, Casey PG, Hill C, Gahan CG, Ross RP, McAuliffe O, O'Mahony J, Maher F, Coffey A (2010) 'The truncated phage lysin CHAP(k) eliminates Staphylococcus aureus in the nares of mice'. Bioengineered Bugs, [Details]
(2010)'Lactococcus lactis: From the Dairy Industry to Antigen and Therapeutic Protein Delivery'
Bahey-El-Din, M,Gahan, CGM (2010) 'Lactococcus lactis: From the Dairy Industry to Antigen and Therapeutic Protein Delivery'. Discovery Medicine, 48 :455-461 [Details]
(2010)'Expression of two Listeria monocytogenes antigens (P60 and LLO) in Lactococcus lactis and examination for use as live vaccine vectors'
Bahey-El-Din M, Casey PG, Griffin BT, Gahan CG (2010) 'Expression of two Listeria monocytogenes antigens (P60 and LLO) in Lactococcus lactis and examination for use as live vaccine vectors'. Journal of Medical Microbiology, [Details]
(2010)'Molecular pathogenesis of Listeria monocytogenes in the alternative model host Galleria mellonella'
Joyce SA, Gahan CG; (2010) 'Molecular pathogenesis of Listeria monocytogenes in the alternative model host Galleria mellonella'. Microbiology, 156 (Pt 11):3456-3468 [DOI] [Details]
(2010)'Innate crosstalk of gamma delta T cells, neutrophils and monocytes in response to HMB-PP producing bacteria [Abstract]'
Davey, Martin S and Heuston, S and Brown, A and Walsh, Timothy Rutland and Toleman, Mark Alexander Howard and Gahan, CGM and Hill, C and Parish, T and Moser, Bernhard and Eberl, Matthias and others (2010) 'Innate crosstalk of gamma delta T cells, neutrophils and monocytes in response to HMB-PP producing bacteria [Abstract]'. Immunology Today, 131 :63-63 [Details]
(2010)'The use of Listeria monocytogenes as a DNA delivery vector for cancer gene therapy'
Tangney, M.,van Pijkeren, J. P.,Gahan, C. G.; (2010) 'The use of Listeria monocytogenes as a DNA delivery vector for cancer gene therapy'. Bioeng Bugs, 1 (44):284-7284 Globe icon [Details]
(2010)'A five-gene stress survival islet (SSI-1) that contributes to the growth of Listeria monocytogenes in suboptimal conditions'
Ryan, S and Begley, M and Hill, C and Gahan, CGM (2010) 'A five-gene stress survival islet (SSI-1) that contributes to the growth of Listeria monocytogenes in suboptimal conditions'. Journal of Applied Microbiology, 109 (3):984-995 [Details]
(2010)'A novel Listeria monocytogenes-based DNA delivery system for cancer gene therapy'
van Pijkeren, JP; Morrissey, D; Monk, IR; Cronin, M; Rajendran, S; O'Sullivan, GC; Gahan, CG; Tangney, M; (2010) 'A novel Listeria monocytogenes-based DNA delivery system for cancer gene therapy'. Human Gene Therapy, 21 (4):405-416 [DOI] [Details]
(2010)'Directed evolution and targeted mutagenesis to murinize Listeria monocytogenes internalin A for enhanced infectivity in the murine oral infection model'
Monk IR, Casey PG, Hill C, Gahan CG (2010) 'Directed evolution and targeted mutagenesis to murinize Listeria monocytogenes internalin A for enhanced infectivity in the murine oral infection model'. BMC Microbiology, [Details]
(2010)'Listeria monocytogenes as a vector for anti-cancer therapies'
Tangney, M; Gahan, CG; (2010) 'Listeria monocytogenes as a vector for anti-cancer therapies'. Current Gene Therapy, 10 (1):46-55 [Details]
(2010)'Bacterial vectors for gene and cell therapy'
Tangney T and Gahan CG (2010) 'Bacterial vectors for gene and cell therapy'. Current Gene Therapy, 10 (1):1-2 [Details]
(2009)'AgrD-dependent quorum sensing affects biofilm formation, invasion, virulence and global gene expression profiles in Listeria monocytogenes'
Riedel CU, Monk IR, Casey PG, Waidmann MS, Gahan CG, Hill C (2009) 'AgrD-dependent quorum sensing affects biofilm formation, invasion, virulence and global gene expression profiles in Listeria monocytogenes'. Molecular Microbiology, [Details]
(2009)'Evaluation of colostrum-derived human mammary-associated serum amyloid A3 (M-SAA3) protein and peptide derivatives for the prevention of enteric infection: in vitro and in murine models of intestinal disease'
Gardiner, G.E. and O'Flaherty, S. and Casey, P.G. and Weber, A. and McDonald, T.L. and Cronin, M. and Hill, C. and Ross, R.P. and Gahan, C.G.M. and Shanahan, F. (2009) 'Evaluation of colostrum-derived human mammary-associated serum amyloid A3 (M-SAA3) protein and peptide derivatives for the prevention of enteric infection: in vitro and in murine models of intestinal disease'. FEMS Immunology \& Medical Microbiology, 55 (3):404-413 [Details]
(2009)'Understanding the mechanisms by which probiotics inhibit gastrointestinal pathogens'
Corr, S.C. and Hill, C. and Gahan, C.G.M. (2009) 'Understanding the mechanisms by which probiotics inhibit gastrointestinal pathogens'. Advances in Food and Nutrition Research, 56 :1-15 [Details]
(2009)'The interaction between Listeria monocytogenes and the host gastrointestinal tract'
Sleator, R.D. and Watson, D. and Hill, C. and Gahan, C.G.M. (2009) 'The interaction between Listeria monocytogenes and the host gastrointestinal tract'. Microbiology, 155 (8) [Details]
(2009)'Specific osmolyte transporters mediate bile tolerance in Listeria monocytogenes'
Watson, D; Sleator, RD; Casey, PG; Hill, C; Gahan, CG; (2009) 'Specific osmolyte transporters mediate bile tolerance in Listeria monocytogenes'. Infection and Immunity, 77 (11):4895-4904 [DOI] [Details]
(2009)'Molecular characterization of the arginine deiminase system in Listeria monocytogenes: regulation and role in acid tolerance'
Ryan, S. and Begley, M. and Gahan, C.G.M. and Hill, C. (2009) 'Molecular characterization of the arginine deiminase system in Listeria monocytogenes: regulation and role in acid tolerance'. Environmental Microbiology, 11 (2):432-445 [Details]
(2008)'Functional and comparative metagenomic analysis of bile salt hydrolase activity in the human gut microbiome'
Jones, B.V. and Begley, M. and Hill, C. and Gahan, C.G.M. and Marchesi, J.R. (2008) 'Functional and comparative metagenomic analysis of bile salt hydrolase activity in the human gut microbiome'. Proceedings of the National Academy of Sciences, 105 (36) [Details]
(2008)'Tools for functional postgenomic analysis of Listeria monocytogenes'
Monk, I.R. and Gahan, C.G.M. and Hill, C. (2008) 'Tools for functional postgenomic analysis of Listeria monocytogenes'. Applied and environmental microbiology, 74 (13):3921-3934 [Details]
(2008)'3 Stress Responses'
Stack, H.M. and Hill, C. and Gahan, C.G.M. (2008) '3 Stress Responses'. Handbook of Listeria monocytogenes, [Details]
(2008)'Enhancing Bile Tolerance Improves Survival and Persistence of Bifidobacterium and Lactococcus In The Murine Gastrointestinal Tract'
Watson, D, Sleator, RD, Hill, C, Gahan, CGM; (2008) 'Enhancing Bile Tolerance Improves Survival and Persistence of Bifidobacterium and Lactococcus In The Murine Gastrointestinal Tract'. BMC Microbiology, 8 (NA) [DOI] [Details]
(2008)'Nisin inducible production of listeriolysin O in Lactococcus lactis NZ9000'
Bahey-El-Din M, Griffin BT, Gahan CG; (2008) 'Nisin inducible production of listeriolysin O in Lactococcus lactis NZ9000'. Microbial Cell Factories, 7 [DOI] [Full Text] [Details]
(2008)'Pseudomonas aeruginosa RsmA plays an important role during murine infection by influencing colonization, virulence, persistence, and pulmonary inflammation'
Mulcahy H, O'Callaghan J, O'Grady EP, Maciá MD, Borrell N, Gómez C, Casey PG, Hill C, Adams C, Gahan CG, Oliver A, O'Gara F; (2008) 'Pseudomonas aeruginosa RsmA plays an important role during murine infection by influencing colonization, virulence, persistence, and pulmonary inflammation'. Infection and Immunity, 76 (2):632-638 [DOI] [Details]
(2008)'Development of Multiple Strain Competitive Index Assays For Listeria Monocytogenes Using Pimc; A New Site-Specific Integrative Vector'
Monk, IR, Casey, PG, Cronin, M, Gahan, CG, Hill, C; (2008) 'Development of Multiple Strain Competitive Index Assays For Listeria Monocytogenes Using Pimc; A New Site-Specific Integrative Vector'. BMC Microbiology, 8 (NA) [DOI] [Details]
(2008)'Lactococcus lactis-expressing listeriolysin O (LLO) provides protection and specific CD8(+) T cells against Listeria monocytogenes in the murine infection model'
Bahey-El-Din, M,Casey, PG,Griffin, BT,Gahan, CGM; (2008) 'Lactococcus lactis-expressing listeriolysin O (LLO) provides protection and specific CD8(+) T cells against Listeria monocytogenes in the murine infection model'. Vaccine, 26 :5304-5314 [DOI] [Details]
(2008)'Analysis of the Isoprenoid Biosynthesis Pathways in Listeria monocytogenes Reveals a Role for the Alternative 2-C-Methyl-D-Erythritol 4-Phosphate Pathway in Murine Infection'
Begley, M,Bron, PA,Heuston, S,Casey, PG,Englert, N,Wiesner, J,Jomaa, H,Gahan, CGM,Hill, C; (2008) 'Analysis of the Isoprenoid Biosynthesis Pathways in Listeria monocytogenes Reveals a Role for the Alternative 2-C-Methyl-D-Erythritol 4-Phosphate Pathway in Murine Infection'. Infection and Immunity, 76 :5392-5401 [DOI] [Details]
(2008)'A significant role for Sigma B in the detergent stress response of Listeria monocytogenes'
Ryan, EM and Gahan, CGM and Hill, C (2008) 'A significant role for Sigma B in the detergent stress response of Listeria monocytogenes'. Letters of Applied Microbiology, 46 (2):148-154 [Details]
(2008)'Emergency physicians' obligations to managed care patients under cobra'
Ryan, EM and Gahan, CGM and Hill, C (2008) 'Emergency physicians' obligations to managed care patients under cobra'. Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, [Details]
(2008)'Pseudomonas aeruginosa RsmA plays an important role during murine infection by influencing colonization, virulence, persistence, and pulmonary inflammation'
Mulcahy, H. and O'Callaghan, J. and O'Grady, E.P. and Macia, M.D. and Borrell, N. and Gomez, C. and Casey, P.G. and Hill, C. and Adams, C. and Gahan, C.G.M. and others (2008) 'Pseudomonas aeruginosa RsmA plays an important role during murine infection by influencing colonization, virulence, persistence, and pulmonary inflammation'. Infection and immunity, 76 (2) [Details]
(2008)'M-cells: origin, morphology and role in mucosal immunity and microbial pathogenesis'
Corr, S.C. and Gahan, C.G.M. and Hill, C. (2008) 'M-cells: origin, morphology and role in mucosal immunity and microbial pathogenesis'. Fems Immunology and Medical Microbiology, 52 (1):2-12 [Details]
(2008)'Acid Stress Responses in Listeria monocytogenes'
Ryan, S. and Hill, C. and Gahan, C.G.M. (2008) 'Acid Stress Responses in Listeria monocytogenes'. Advances In Applied Microbiology, 65 :67-91 [Details]
(2007)'An improved luciferase tagging system for Listeria monocytogenes allows real-time monitoring in vivo and in vitro'
Riedel CU, Monk IR, Casey PG, Morrissey D, O'Sullivan GC, Tangney M, Hill C and Gahan CGM.; (2007) 'An improved luciferase tagging system for Listeria monocytogenes allows real-time monitoring in vivo and in vitro'. Applied and Environmental Microbiology, 73 (9):3091-3094 [Details]
(2007)'Construction of p16Slux, a Novel Vector for Improved Bioluminescent Labelling of Gram-Negative Bacteria'
Riedel CU, Casey PG, Mulcahy H, O'Gara F, Gahan CGM and Hill C.; (2007) 'Construction of p16Slux, a Novel Vector for Improved Bioluminescent Labelling of Gram-Negative Bacteria'. Applied Environmental Microbiology, 73 (21):7092-7095 [Details]
(2007)'Bacteriocin production as a mechanism for the antiinfective activity of Lactobacillus salivarius UCC118'
Corr, S.C. and Li, Y. and Riedel, C.U. and O'Toole, P.W. and Hill, C. and Gahan, C.G.M. (2007) 'Bacteriocin production as a mechanism for the antiinfective activity of Lactobacillus salivarius UCC118'. Proceedings of the National Academy of Sciences, 104 (18) [Details]
(2007)'Impact of selected Lactobacillus and Bifidobacterium species on Listeria monocytogenes infection and the mucosal immune response'
Corr, S.C. and Gahan, C.G.M. and Hill, C. (2007) 'Impact of selected Lactobacillus and Bifidobacterium species on Listeria monocytogenes infection and the mucosal immune response'. FEMS Immunology \& Medical Microbiology, 50 (3):380-388 [Details]
(2007)'The Glutamate Decarboxylase Acid Resistance Mechanism Affects Survival of Listeria Monocytogenes Lo28 In Modified Atmosphere-Packaged Foods'
Francis, GA, Scollard, J, Meally, A, Bolton, DJ, Gahan, CGM, Cotter, PD, Hill, C, O'Beirne, D; (2007) 'The Glutamate Decarboxylase Acid Resistance Mechanism Affects Survival of Listeria Monocytogenes Lo28 In Modified Atmosphere-Packaged Foods'. Journal of Applied Microbiology, 103 (6):2316-2324 [DOI] [Details]
(2007)'A novel promoter trap identifies Listeria monocytogenes promoters expressed at a low pH within the macrophage phagosome'
Stack HM, Gahan CG, Hill C; (2007) 'A novel promoter trap identifies Listeria monocytogenes promoters expressed at a low pH within the macrophage phagosome'. Fems Microbiology Letters, 274 (1):139-147 [DOI] [Details]
(2007)'Induction of epithelial cell Cc120 by Listeria monocytogenes is dependent upon entry to the host cell cytosol'
Corr, S. C.,O'hara, A. M.,O'mahony, L.,Shanahan, F.,Hill, C.,Gahan, C. G. (2007) 'Induction of epithelial cell Cc120 by Listeria monocytogenes is dependent upon entry to the host cell cytosol'. Gastroenterology, 132 (44) Globe icon [Details]
(2006)'An in vitro cell-culture model demonstrates internalin- and hemolysin-independent translocation of Listeria monocytogenes across M cells'
Corr S, Hill C, Gahan CG; (2006) 'An in vitro cell-culture model demonstrates internalin- and hemolysin-independent translocation of Listeria monocytogenes across M cells'. Microbial Pathogenesis, 41 (6):241-250 [DOI] [Details]
(2006)'Bile salt hydrolase activity in probiotics'
Begley M, Hill C, Gahan CG; (2006) 'Bile salt hydrolase activity in probiotics'. Applied and Environmental Microbiology, 72 (3):1729-1738 [DOI] [Details]
(2006)'A novel luciferase reporter system for monitoring in vitro and organ-specific differential gene expression in Listeria monocytogenes'
Bron PA, IR Monk, SC Corr, C Hill and CGM Gahan.; (2006) 'A novel luciferase reporter system for monitoring in vitro and organ-specific differential gene expression in Listeria monocytogenes'. Applied and Environmental Microbiology, 72 (4):2876-2884 [Details]
(2006)'Removal of digoxin from the circulation using immobilized monoclonal antibodies'
Ryan, EM and Gahan, CGM and Hill, C (2006) 'Removal of digoxin from the circulation using immobilized monoclonal antibodies'. Journal of Pharmaceutical Sciences, [Details]
(2006)'INCIDENCE OF BSH ACTIVITY AMONG BACTERIA'
Begley, M. and Hill, C. and Gahan, C.G.M. (2006) 'INCIDENCE OF BSH ACTIVITY AMONG BACTERIA'. Appl Environ Microbiol, 72 (3):1729-1738 [Details]
(2005)'PATHOGENS AND PATHOGENICITY-The Dps-like protein Fri of Listeria monocytogenes promotes stress tolerance and intracellular multiplication in macrophage-like cells'
Olsen, KN and Larsen, MH and Gahan, CGM and Kallipolitis, B. and Wolf, XA and Rea, R. and Hill, C. and Ingmer, H. (2005) 'PATHOGENS AND PATHOGENICITY-The Dps-like protein Fri of Listeria monocytogenes promotes stress tolerance and intracellular multiplication in macrophage-like cells'. Microbiology-Reading, 151 (3):925-934 [Details]
(2005)'The Dps-like protein Fri of Listeria monocytogenes promotes stress tolerance and intracellular multiplication in macrophage-like cells'
Olsen, K.N. and Larsen, M.H. and Gahan, C.G.M. and Kallipolitis, B. and Wolf, X.A. and Rea, R. and Hill, C. and Ingmer, H. (2005) 'The Dps-like protein Fri of Listeria monocytogenes promotes stress tolerance and intracellular multiplication in macrophage-like cells'. Microbiology, 151 (3) [Details]
(2005)'Contribution of three bile-associated loci, bsh, pva, and btlB, to gastrointestinal persistence and bile tolerance of Listeria monocytogenes. '
Begley M, Sleator RD, Gahan* CG, Hill C.; (2005) 'Contribution of three bile-associated loci, bsh, pva, and btlB, to gastrointestinal persistence and bile tolerance of Listeria monocytogenes. '. Infection and Immunity, 73 (2):894-904 [Details]
(2005)'Presence of GadD1 glutamate decarboxylase in selected Listeria monocytogenes strains is associated with an ability to grow at low pH'
Cotter, PD,Ryan, S,Gahan, CGM,Hill, C; (2005) 'Presence of GadD1 glutamate decarboxylase in selected Listeria monocytogenes strains is associated with an ability to grow at low pH'. Applied and Environmental Microbiology, 71 :2832-2839 [DOI] [Details]
(2005)'Listeria monocytogenes PerR mutants display a small-colony phenotype, increased sensitivity to hydrogen peroxide, and significantly reduced murine virulence'
Rea, R,Hill, C,Gahan, CGM; (2005) 'Listeria monocytogenes PerR mutants display a small-colony phenotype, increased sensitivity to hydrogen peroxide, and significantly reduced murine virulence'. Applied and Environmental Microbiology, 71 :8314-8322 [DOI] [Details]
(2005)'Role for HtrA in stress induction and virulence potential in Listeria monocytogenes'
Stack, HM,Sleator, RD,Bowers, M,Hill, C,Gahan, CGM; (2005) 'Role for HtrA in stress induction and virulence potential in Listeria monocytogenes'. Applied and Environmental Microbiology, 71 :4241-4247 [DOI] [Details]
(2005)'Gastrointestinal phase of Listeria monocytogenes infection'
Gahan CG, Hill C; (2005) 'Gastrointestinal phase of Listeria monocytogenes infection'. Journal of Applied Microbiology, 98 (6):1345-1353 [DOI] [Details]
(2005)'The interaction between bacteria and bile'
Begley M, Gahan CG, Hill C; (2005) 'The interaction between bacteria and bile'. Fems Microbiology Reviews, 29 (4):625-651 [DOI] [Details]
(2005)'Listeria monocytogenes PerR mutants display a small-colony phenotype, increased sensitivity to hydrogen peroxide, and significantly reduced murine virulence'
Rea R, Hill C, Gahan CG; (2005) 'Listeria monocytogenes PerR mutants display a small-colony phenotype, increased sensitivity to hydrogen peroxide, and significantly reduced murine virulence'. Applied and Environmental Microbiology, 71 (12):8314-8322 [DOI] [Details]
(2005)'A PrfA-regulated bile exclusion system (BilE) is a novel virulence factor in Listeria monocytogenes'
Sleator RD, Wemekamp-Kamphuis HH, Gahan CG, Abee T, Hill C.; (2005) 'A PrfA-regulated bile exclusion system (BilE) is a novel virulence factor in Listeria monocytogenes'. Molecular Microbiology, 55 (4):1183-1195 [Details]
(2004)'Disruption of putative regulatory loci in Listeria monocytogenes demonstrates a significant role for fur and PerR in virulence'
Rea, RB,Gahan, CGM,Hill, C; (2004) 'Disruption of putative regulatory loci in Listeria monocytogenes demonstrates a significant role for fur and PerR in virulence'. Infection and Immunity, 72 :717-727 [DOI] [Details]
(2004)'The interplay between classical and alternative isoprenoid biosynthesis controls gammadelta T cell bioactivity of Listeria monocytogenes'
Begley M, Gahan CG, Kollas AK, Hintz M, Hill C, Jomaa H, Eberl M; (2004) 'The interplay between classical and alternative isoprenoid biosynthesis controls gammadelta T cell bioactivity of Listeria monocytogenes'. Febs Letters, 561 (1-3):99-104 [DOI] [Details]
(2003)'Analysis of the contribution of betaine and carnitine uptake systems to the growth and survival of listeria monocytogenes in foods and during infection'
Sleator, RD., Francis, GA., O'Beirne, DD., Gahan*, C., Hill,C.; (2003) 'Analysis of the contribution of betaine and carnitine uptake systems to the growth and survival of listeria monocytogenes in foods and during infection'. Journal of Applied Microbiology, 95 (4):839-846 [Details]
(2003)'Bacterial stress response in listeria monocytogenes: jumping the hurdles inposed by minimal processing'
Hill, C., Cotter, PD., Sleator, RD., Gahan, C.; (2003) 'Bacterial stress response in listeria monocytogenes: jumping the hurdles inposed by minimal processing'. International Dairy Journal, 12 (*):273-283 [Details]
(2003)'Identification and disruption of bt1A a locus involved in bile tolerance and general stress resistance in listeia monocytogenes'
Begley, M., Gahan, C., Hill, C.; (2003) 'Identification and disruption of bt1A a locus involved in bile tolerance and general stress resistance in listeia monocytogenes'. Fems Microbiology Letters, 218 (*):31-38 [Details]
(2003)'CesRK, a two-component signal transduction system in Listeria monocytogenes, responds to the presence of cell wall-acting antibiotics and affects $$beta$\$-lactam resistance'
Kallipolitis, B.H. and Ingmer, H. and Gahan, C.G. and Hill, C. and Sogaard-Andersen, L. (2003) 'CesRK, a two-component signal transduction system in Listeria monocytogenes, responds to the presence of cell wall-acting antibiotics and affects $$beta$\$-lactam resistance'. Antimicrobial agents and chemotherapy, 47 (11) [Details]
(2003)'BACTERIAL OSMOADAPTATION'
Sleator, R.D. and Gahan, C.G.M. and Hill, C. (2003) 'BACTERIAL OSMOADAPTATION'. Appl Environ Microbiol, 69 (1):1-9 [Details]
(2003)'The CtsR regulator of Listeria monocytogenes contains a variant glycine repeat region that affects piezotolerance, stress resistance, motility and virulence'
Karatzas, K.A.G. and Wouters, J.A. and Gahan, C.G.M. and Hill, C. and Abee, T. and Bennik, M.H.J. (2003) 'The CtsR regulator of Listeria monocytogenes contains a variant glycine repeat region that affects piezotolerance, stress resistance, motility and virulence'. Molecular microbiology, 49 (5):1227-1238 [Details]
(2003)'Betaine and carnitine uptake systems in Listeria monocytogenes affect growth and survival in foods and during infection'
Sleator, RD and Francis, GA and O'Beirne, D. and Gahan, CGM and Hill, C. (2003) 'Betaine and carnitine uptake systems in Listeria monocytogenes affect growth and survival in foods and during infection'. Journal of applied microbiology, 95 (4):839-846 [Details]
(2003)'A postgenomic appraisal of osmotolerance in Listeria monocytogenes'
Sleator, RD and Gahan, CGM and Hill, C; (2003) 'A postgenomic appraisal of osmotolerance in Listeria monocytogenes'. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 69 (1):1-9 [DOI] [Details]
(2003)'A two component signal transduction system in listeria monocytogenes responds to the presence of cell wall acting antobiotics and affects betalactam resistance'
Kallipolitis, BH., Ingmer, H., Gahan, C., Hill, C., Sogaard-Andersen, L.; (2003) 'A two component signal transduction system in listeria monocytogenes responds to the presence of cell wall acting antobiotics and affects betalactam resistance'. Antimicrobial Agents and Chemotherapy, 47 (11):3421-3429 [Details]
(2003)'A single amino acid deletion in the glycine rich region of CtsrR affects motilit, piezotolerance and virulence of listeria monocytogenes'
Karatzas, KAD, Wouters, C., Gahan, C., Hill, C., Abee, T., Bennik, MHJ.; (2003) 'A single amino acid deletion in the glycine rich region of CtsrR affects motilit, piezotolerance and virulence of listeria monocytogenes'. Molecular Microbiology, 49 (*):1227-1238 [Details]
(2003)'Identification and disruption of btlA, a locus involved in bile tolerance and general stress resistance in Listeria monocytogenes'
Begley, M,Hill, C,Gahan, CGM; (2003) 'Identification and disruption of btlA, a locus involved in bile tolerance and general stress resistance in Listeria monocytogenes'. Fems Microbiology Letters, 218 :31-38 [DOI] [Details]
(2002)'Bile stress response in Listeria monocytogenes LO28: adaptation, cross-protection, and identification of genetic loci involved in bile resistance'
Begley M, Gahan CG, Hill C; (2002) 'Bile stress response in Listeria monocytogenes LO28: adaptation, cross-protection, and identification of genetic loci involved in bile resistance'. Applied and Environmental Microbiology, 68 (12):6005-6012 [Details]
(2002)'Multiple deletions of the osmolyte transporters BetL, Gbu, and OpuC of Listeria monocytogenes affect virulence and growth at high osmolarity'
Wemekamp-Kamphuis, H.H. and Wouters, J.A. and Sleator, R.D. and Gahan, C.G.M. and Hill, C. and Abee, T. (2002) 'Multiple deletions of the osmolyte transporters BetL, Gbu, and OpuC of Listeria monocytogenes affect virulence and growth at high osmolarity'. Applied and environmental microbiology, 68 (10) [Details]
(2002)'Bacterial stress response in Listeria monocytogenes: jumping the hurdles imposed by minimal processing'
Hill, C and Cotter, PD and Sleator, RD and Gahan, CGM; (2002) 'Bacterial stress response in Listeria monocytogenes: jumping the hurdles imposed by minimal processing'. INTERNATIONAL DAIRY JOURNAL, 12 (2-3, Sp. Iss. SI):273-283 [Details]
(2001)'A glutamate decarboxylase system protects Listeria monocytogenes in gastric fluid'
Cotter, PD,Gahan, CGM,Hill, C; (2001) 'A glutamate decarboxylase system protects Listeria monocytogenes in gastric fluid'. Molecular Microbiology, 40 :465-475 [Details]
(2001)'Characterization of the groESL operon in Listeria monocytogenes: Utilization of two reporter systems (gfp and hly) for evaluating in vivo expression'
Gahan, CGM,O'Mahony, J,Hill, C; (2001) 'Characterization of the groESL operon in Listeria monocytogenes: Utilization of two reporter systems (gfp and hly) for evaluating in vivo expression'. Infection and Immunity, 69 :3924-3932 [Details]
(2001)'Identification and disruption of the proBA locus in Listeria monocytogenes: Role of proline biosynthesis in salt tolerance and murine infection'
Sleator, RD,Gahan, CGM,Hill, C; (2001) 'Identification and disruption of the proBA locus in Listeria monocytogenes: Role of proline biosynthesis in salt tolerance and murine infection'. Applied and Environmental Microbiology, 67 :2571-2577 [Details]
(2001)'Mutations in the listerial proB gene leading to proline overproduction: Effects on salt tolerance and murine infection'
Sleator, RD,Gahan, CGM,Hill, C; (2001) 'Mutations in the listerial proB gene leading to proline overproduction: Effects on salt tolerance and murine infection'. Applied and Environmental Microbiology, 67 :4560-4565 [Details]
(2001)'Analysis of the role of OpuC, an osmolyte transport system, in salt tolerance and virulence potential of Listeria monocytogenes. '
Sleator RD, Wouters J, Gahan CG, Abee T, Hill C.; (2001) 'Analysis of the role of OpuC, an osmolyte transport system, in salt tolerance and virulence potential of Listeria monocytogenes. '. Applied Environmental Microbiology, 67 (6):2692-2698 [Details]
(2001)'PHYSIOLOGY AND BIOTECHNOLOGY-Identification and Disruption of the proBA Locus in Listeria monocytogenes: Role of Proline Biosynthesis in Salt Tolerance and Murine Infection'
Sleator, R.D. and Gahan, C.G.M. and Hill, C. (2001) 'PHYSIOLOGY AND BIOTECHNOLOGY-Identification and Disruption of the proBA Locus in Listeria monocytogenes: Role of Proline Biosynthesis in Salt Tolerance and Murine Infection'. Applied and Environmental Microbiology, 67 (6):2571-2577 [Details]
(2001)'MOLECULAR PATHOGENESIS-Characterization of the groESL Operon in Listeria monocytogenes: Utilization of Two Reporter Systems (gfp and hly) for Evaluating In Vivo Expression'
Gahan, C.G.M. and O'Mahony, J. and Hill, C. (2001) 'MOLECULAR PATHOGENESIS-Characterization of the groESL Operon in Listeria monocytogenes: Utilization of Two Reporter Systems (gfp and hly) for Evaluating In Vivo Expression'. Infection and Immunity, 69 (6):3924-3932 [Details]
(2000)'The use of listeriolysin to identify in vivo induced genes in the Gram-positive intracellular pathogen Listeria monocytogenes'
Gahan, C.G.M. and Hill, C. (2000) 'The use of listeriolysin to identify in vivo induced genes in the Gram-positive intracellular pathogen Listeria monocytogenes'. Molecular Microbiology, 36 (2):498-507 [Details]
(2000)'Analysis of the role of the Listeria monocytogenes F0F1-ATPase operon in the acid tolerance response'
Cotter, P.D. and Gahan, C.G.M. and Hill, C. (2000) 'Analysis of the role of the Listeria monocytogenes F0F1-ATPase operon in the acid tolerance response'. International journal of food microbiology, 60 (2-3):137-146 [Details]
(2000)'Analysis of the role of betL in contributing to the growth and survival of Listeria monocytogenes LO28. '
Sleator RD, Gahan CGM, O'Driscoll B, Hill C.; (2000) 'Analysis of the role of betL in contributing to the growth and survival of Listeria monocytogenes LO28. '. International Journal of Food Microbiology, 60 (2-3):261-268 [Details]
(2000)'Listeria monocytogenes: role of stress in virulence and survival in food'
Hill, C and C. Gahan.; (2000) 'Listeria monocytogenes: role of stress in virulence and survival in food'. Irish Journal of Agricultural Food Research, 39 (*):195-202 [Details]
(1999)'Identification and disruption of lisRK, a genetic locus encoding a two-component signal transduction system involved in stress tolerance and virulence in Listeria monocytogenes'
Cotter PD, Emerson N, Gahan CG, Hill C; (1999) 'Identification and disruption of lisRK, a genetic locus encoding a two-component signal transduction system involved in stress tolerance and virulence in Listeria monocytogenes'. Journal of Bacteriology, 181 (21):6840-6843 [Details]
(1999)'GENETICS AND MOLECULAR BIOLOGY-Identification and Disruption of BetL, a Secondary Glycine Betaine Transport System Linked to the Salt Tolerance of Listeria monocytogenes LO28'
Sleator, R.D. and Gahan, C.G.M. and Abee, T. and Hill, C. (1999) 'GENETICS AND MOLECULAR BIOLOGY-Identification and Disruption of BetL, a Secondary Glycine Betaine Transport System Linked to the Salt Tolerance of Listeria monocytogenes LO28'. Applied and Environmental Microbiology, 65 (5):2078-2083 [Details]
(1999)'Identification and disruption of BetL, a secondary glycine betaine transport system linked to the salt tolerance of Listeria monocytogenes LO28. '
Sleator RD, Gahan CG, Abee T, Hill C.; (1999) 'Identification and disruption of BetL, a secondary glycine betaine transport system linked to the salt tolerance of Listeria monocytogenes LO28. '. Applied Environmental Microbiology, 65 (5):2078-2083 [Details]
(1999)'Acid-adapted Listeria monocytogenes displays enhanced tolerance against the lantibiotics nisin and lacticin 3147'
Van Schaik, W. and Gahan, C.G.M. and Hill, C. (1999) 'Acid-adapted Listeria monocytogenes displays enhanced tolerance against the lantibiotics nisin and lacticin 3147'. Journal of Food Protection, 62 (5):536-540 [Details]
(1999)'The relationship between acid stress responses and virulence in Salmonella typhimurium and Listeria monocytogenes'
Gahan, CGM and Hill, C; (1999) 'The relationship between acid stress responses and virulence in Salmonella typhimurium and Listeria monocytogenes'. INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY, 50 (1-2):93-100 [Details]
(1997)'Two Dimensional protein analysis of the acid tolerance response in Listeria monocytogenes L028'
O'Driscoll, B.; Gahan, C.; Hill, Colin; (1997) 'Two Dimensional protein analysis of the acid tolerance response in Listeria monocytogenes L028'. Applied and Environmental Microbiology, 63 (*):2679-2685 [Details]
(1997)'Innate Resistance to Listeria Monocytogenes in Tumor-Bearing Mice [B2319]'
Gahan, C.; Barrett, M.; O'Brien, M.; O'Sullivan, G.; Shanahan, F.; Collins, J. K.; (1997) 'Innate Resistance to Listeria Monocytogenes in Tumor-Bearing Mice [B2319]'. Journal of Leukocyte Biology, 62 :726-732 [Details]
(1997)'Innate resistance to Listeria monocytogenes in tumor-bearing mice'
Gahan, C. G. M. and Barrett, J. R. and Obrien, M. G. and Osullivan, G. C. and Shanahan, F. and Collins, J. K. (1997) 'Innate resistance to Listeria monocytogenes in tumor-bearing mice'. Journal of Leukocyte Biology, 62 (6):726-732 [Details]
(1997)'A mutant of Listeria monocytogenes LO28 unable to induce an acid tolerance response displays diminished virulence in a murine model. '
Marron L, Emerson N, Gahan CG, Hill C.; (1997) 'A mutant of Listeria monocytogenes LO28 unable to induce an acid tolerance response displays diminished virulence in a murine model. '. Applied and Environmental Microbiology, 63 (12):4945-4947 [Details]
(1997)'Two-dimensional polyacrylamide gel electrophoresis analysis of the acid tolerance response in Listeria monocytogenes LO28'
O'Driscoll, B. and Gahan, C.G.M. and Hill, C. (1997) 'Two-dimensional polyacrylamide gel electrophoresis analysis of the acid tolerance response in Listeria monocytogenes LO28'. Applied and environmental microbiology, 63 (7) [Details]
(1997)'Innate Resistance to {Listeria Monocytogenes} in Tumor-Bearing Mice [B1646]'
Gahan, C. G.; Barrett, J. R.; O'Brien, M. G.; O'Sullivan, G. C.; Shanahan, F.; Collins, J. K.; (1997) 'Innate Resistance to {Listeria Monocytogenes} in Tumor-Bearing Mice [B1646]'. Journal of Leukocyte Biology, 62 :726-732 [Details]
(1996)'Acid Adaptation of Listeria Monocytogenes Can Enhance Survival in Acidic Foods and During Milk Fermentation [B2351]'
Gahan, C.; O'Driscoll, B.; Hill, Colin; (1996) 'Acid Adaptation of Listeria Monocytogenes Can Enhance Survival in Acidic Foods and During Milk Fermentation [B2351]'. Applied and Environmental Microbiology, 62 (*):3128-2132 [Details]
(1996)'Adaptive Acid Tolerance Response in {Listeria Monocytogenes}: Isolation of an Acid-Tolerant Mutant Which Demonstrates Increased Virulence [B2350]'
O'Driscoll, B.; Gahan, C.; Hill, Colin; (1996) 'Adaptive Acid Tolerance Response in {Listeria Monocytogenes}: Isolation of an Acid-Tolerant Mutant Which Demonstrates Increased Virulence [B2350]'. Applied and Environmental Microbiology, :1693-1698 [Details]
(1995)'Vaccination of mice with attenuated mutants of Listeria monocytogenes : requirement for induction of macrophage Ia expression'
Gahan CG and JK Collins; (1995) 'Vaccination of mice with attenuated mutants of Listeria monocytogenes : requirement for induction of macrophage Ia expression'. Microbial Pathogenesis, 18 :417-422 [Details]
(1995)'Non-dystrophic 129 REJ mice are susceptible to i.p. infection with Listeria monocytogenes despite an ability to recruit inflammatory neutrophils to the peritoneal cavity'
Gahan CG and JK Collins; (1995) 'Non-dystrophic 129 REJ mice are susceptible to i.p. infection with Listeria monocytogenes despite an ability to recruit inflammatory neutrophils to the peritoneal cavity'. Microbial Pathogenesis, 18 :355-364 [Details]
(1991)'Listeriosis: Biology and implications for the food industry'
Gahan CG and JK Collins; (1991) 'Listeriosis: Biology and implications for the food industry'. Trends in Food Science & Technology, 2 :89-93 [Details]

Book Chapters

YearPublication
(2014)'Vaccination studies: Detection of a Listeria monocytogenes specific T cell immune response using the ELISPOT technique'
Bahey-el-din M and CGM Gahan (2014) 'Vaccination studies: Detection of a Listeria monocytogenes specific T cell immune response using the ELISPOT technique' In: Methods in Molecular Biology – Listeria mo. USA: Springer. [Details]
(2013)'Functional and comparative metagenomic analysis of bile salt hydrolase activity'
Jones BV and Gahan C.G.M. (2013) 'Functional and comparative metagenomic analysis of bile salt hydrolase activity' In: Encyclopedia of Metagenomics. USA: Springer. [Details]
(2011)'The gut microbiota, probiotics and infectious disease'
Gahan CG, O’Sullivan GC and JK Collins (2011) 'The gut microbiota, probiotics and infectious disease' In: Probiotic Bacteria and Enteric Infections. USA: Springer. [Details]
(2010)'Responses of Listeria monocytogenes to different stresses'
Dowd G, Hill C and CGM Gahan; (2010) 'Responses of Listeria monocytogenes to different stresses' In: Stress responses in foodborne pathogens. New York: Nova Science Publishers. [Details]
(2008)'Attack and counter-attack: targeted immunomodulation using bacterial virulence factors'
Bahey-El-Din M, Griffin BT and CGM Gahan; (2008) 'Attack and counter-attack: targeted immunomodulation using bacterial virulence factors' In: Patho-Biotechnology. Austin: Landes BioSciences. [Details]
(2008)'Listeria monocytogenes: stress responses'
Stack, HM, Hill C, CGM Gahan; (2008) 'Listeria monocytogenes: stress responses' In: Handbook of Listeria monocytogenes. Cambridge: CRC Press. [Details]
(2006)'Specific immune mechanisms of defence against foodborne pathogens'
Gahan CG; (2006) 'Specific immune mechanisms of defence against foodborne pathogens' In: Food consumption and disease risk. Cambridge: CRC Press. [Details]
(2003)'Microbial adaptation to stress and safety of new generation foods¿. (Yousef, A. E. and V. Juneja; Eds.)'
Gahan, C., and C. Hill. ; (2003) 'Microbial adaptation to stress and safety of new generation foods¿. (Yousef, A. E. and V. Juneja; Eds.)' In: Relationship of stress adaptation and virulence in foodborne pathogenic bacteria. CRC Press, Florida, USA: CRC Press. [Details]
(2003)'Relationship between stress adaptation and virulence in foodborne pathogenic bacteria'
Gahan CG and C Hill; (2003) 'Relationship between stress adaptation and virulence in foodborne pathogenic bacteria' In: Microbial Stress Adaptation and Food Safety. [Details]

Other Journals

YearPublication
(2010)'photoaddition of phenanthraquinone to alkyl-substituted (alkylthio) acetylenes†. chemistry of acetylenic ethers 109'
Ryan, EM and Gahan, CGM and Hill, C (2010) 'photoaddition of phenanthraquinone to alkyl-substituted (alkylthio) acetylenes†. chemistry of acetylenic ethers 109' Recueil des Travaux Chimiques des Pays-Bas, . [Details]
(2004)'cytoarchitecture of the frontal lobe of the squirrel monkey'
Ryan, EM and Gahan, CGM and Hill, C (2004) 'cytoarchitecture of the frontal lobe of the squirrel monkey' The Journal of Comparative Neurology, . [Details]

Conference Publications

YearPublication
(2013)JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
Pereira-Fantini, PM and Lapthorne, S and Joyce, SA and Dellios, NL and Wilson, G and Fouhy, F and Thomas, SL and Scurr, M and Hill, C and Gahan, CGM and others (2013) Disturbed bile acid metabolism as a cause of intestinal failure-associated liver disease in a piglet model of short bowel syndrome JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY , pp.14-15 [Details]
(2008)DDW 2008; Gastroenterology
Corr, S. C.,O'Hara, A.,O'Mahony, L.,Nally, K.,Shanahan, F.,Hill, C.,Gahan, C. G. (2008) Mechanism of epithelial CCL20 response to listeria DDW 2008; Gastroenterology Globe icon [Details]
(2007)INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY
Riedel, CU and Monk, IR and Casey, P and Gahan, CGM and Hill, C (2007) Role of agrD for biofim formation and virulence in L. monocytogenes INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY , pp.137-137 [Details]
(2007)Pseudomonas 2007 (ASM Conference)
O'Callaghan, J and Mulcahy, H and Casey, Pg and Baysse, Christine and O'grady, EP and Hill, C and Adams, C and Gahan, Cg and O'gara, F and others (2007) Comparative analysis of Pseudomonas aeruginosa strains, altered in their ability to cause acute infection, in response to bronchial epithelial cells Pseudomonas 2007 (ASM Conference) [Details]

Abstract

YearPublication
(2012)Influence of Internalin A murinization on host resistance to orally acquired listeriosis in mice.
Bergmann, S,Beard, P,Pasche, B,Lienenklaus, S,Weiss, S,Gahan, CGM,Schughart, K,Lengeling, A (2012) Influence of Internalin A murinization on host resistance to orally acquired listeriosis in mice. Abstract [Details]
(2010)Innate crosstalk of gamma delta T cells, neutrophils and monocytes in response to HMB-PP producing bacteria.
Davey, MS,Heuston, S,Brown, AC,Walsh, TR,Toleman, MA,Gahan, CGM,Hill, C,Parish, T,Moser, B,Eberl, M (2010) Innate crosstalk of gamma delta T cells, neutrophils and monocytes in response to HMB-PP producing bacteria. Abstract [Details]
(2010)Non-pathogenic bacteria as cell therapy vectors for cancer treatment.
Cronin, M,Collins, S,Inagaki, A,Hiraoka, K,Kasahara, N,Gahan, CGM,O'Sullivan, GC,Tangney, M (2010) Non-pathogenic bacteria as cell therapy vectors for cancer treatment. Abstract [Details]
(2007)Role of agrD for biofim formation and virulence in L. monocytogenes.
Riedel, CU,Monk, IR,Casey, P,Gahan, CGM,Hill, C (2007) Role of agrD for biofim formation and virulence in L. monocytogenes. Abstract [Details]

Book Reviews

YearPublication
(2012)The Bacterial lux Reporter System: Applications in Bacterial Localisation Studies.
Gahan, CGM (2012) The Bacterial lux Reporter System: Applications in Bacterial Localisation Studies. Book Reviews [Details]
(2012)Isoprenoid biosynthesis in bacterial pathogens.
Heuston, S,Begley, M,Gahan, CGM,Hill, C (2012) Isoprenoid biosynthesis in bacterial pathogens. Book Reviews [DOI] [Details]
(2011)The impact of iron on Listeria monocytogenes; inside and outside the host.
McLaughlin, HP,Hill, C,Gahan, CGM (2011) The impact of iron on Listeria monocytogenes; inside and outside the host. Book Reviews [DOI] [Details]
(2010)Listeria monocytogenes as a Vector for Anti-Cancer Therapies.
Tangney, M,Gahan, CGM (2010) Listeria monocytogenes as a Vector for Anti-Cancer Therapies. Book Reviews [Details]
(2010)Lactococcus lactis as a Cell Factory for Delivery of Therapeutic Proteins.
Bahey-El-Din, M,Gahan, CGM,Griffin, BT (2010) Lactococcus lactis as a Cell Factory for Delivery of Therapeutic Proteins. Book Reviews [Details]
(2009)The interaction between Listeria monocytogenes and the host gastrointestinal tract.
Sleator, RD,Watson, D,Hill, C,Gahan, CGM (2009) The interaction between Listeria monocytogenes and the host gastrointestinal tract. Book Reviews [DOI] [Details]
(2008)Acid Stress Responses in Listeria monocytogenes.
Ryan, S,Hill, C,Gahan, CGM (2008) Acid Stress Responses in Listeria monocytogenes. Book Reviews [DOI] [Details]
(2006)Bile salt hydrolase activity in probiotics.
Begley, M,Hill, C,Gahan, CGM (2006) Bile salt hydrolase activity in probiotics. Book Reviews [DOI] [Details]
(2005)The interaction between bacteria and bile.
Begley, M,Gahan, CGM,Hill, C (2005) The interaction between bacteria and bile. Book Reviews [DOI] [Details]
(2003)A postgenomic appraisal of osmotolerance in Listeria monocytogenes.
Sleator, RD,Gahan, CGM,Hill, C (2003) A postgenomic appraisal of osmotolerance in Listeria monocytogenes. Book Reviews [DOI] [Details]

Other

YearPublication
(2002)Bacterial stress response in Listeria monocytogenes: jumping the hurdles imposed by minimal processing.
Hill, C,Cotter, PD,Sleator, RD,Gahan, CGM (2002) Bacterial stress response in Listeria monocytogenes: jumping the hurdles imposed by minimal processing. Other [DOI] [Details]
(2000)Analysis of the role of the Listeria monocytogenes F0F1-ATPase operon in the acid tolerance response.
Cotter, PD,Gahan, CGM,Hill, C (2000) Analysis of the role of the Listeria monocytogenes F0F1-ATPase operon in the acid tolerance response. Other [Details]
(2000)Analysis of the role of betL in contributing to the growth and survival of Listeria monocytogenes LO28.
Sleator, RD,Gahan, CGM,O'Driscoll, B,Hill, C (2000) Analysis of the role of betL in contributing to the growth and survival of Listeria monocytogenes LO28. Other [Details]
(2000)Listeria monocytogenes: role of stress in virulence and survival in food.
Hill, C,Gahan, C (2000) Listeria monocytogenes: role of stress in virulence and survival in food. Other [Details]
(1999)The relationship between acid stress responses and virulence in Salmonella typhimurium and Listeria monocytogenes.
Gahan, CGM,Hill, C (1999) The relationship between acid stress responses and virulence in Salmonella typhimurium and Listeria monocytogenes. Other [Details]

Reviews

YearPublication
(2014)Two-tiered biological containment strategy for Lactococcus lactis-based vaccine or immunotherapy vectors.
Hanin, A,Culligan, EP,Casey, PG,Bahey-El-Din, M,Hill, C,Gahan, CGM (2014) Two-tiered biological containment strategy for Lactococcus lactis-based vaccine or immunotherapy vectors. Reviews [DOI] [Details]
(2014)The gut microbiota and the metabolic health of the host.
Joyce, SA,Gahan, CGM (2014) The gut microbiota and the metabolic health of the host. Reviews [DOI] [Details]
(2014)Listeria monocytogenes: survival and adaptation in the gastrointestinal tract.
Gahan, CGM,Hill, C (2014) Listeria monocytogenes: survival and adaptation in the gastrointestinal tract. Reviews [DOI] [Details]

Honours and Awards

 YearTitleAwarding Body
2013APC Scientist of the Year Alimentary Pharmabiotic Centre

Professional Associations

 AssociationFunctionFrom / To
Society for General Microbiology Member/
American Society for Microbiology Member/

Conference Contributions

YearPublication
(2014)The Synthetic Biology Future: SynBio International Conference,
Gahan, CG (2014) BioMedical Applications in Synthetic Microbiology. [Oral Presentation], The Synthetic Biology Future: SynBio International Conference, County Hall, Cork, Ireland , 13-MAR-14. [Details]
(2014)International Scientific Association for Probiotics and Prebiotics (ISAPP) meeting, ROWETT/INRA/ISAPP joint meeting,
Gahan, CG (2014) Hot Topic: Regulation of host metabolism by bacterial bile acid modification in the gut. [Oral Presentation], International Scientific Association for Probiotics and Prebiotics (ISAPP) meeting, ROWETT/INRA/ISAPP joint meeting, Aberdeen Scotland , 18-JUN-14 - 20-JUN-14. [Details]
(2014)Bifidobacteria: applications in infection, inflammation & cance,
Gahan CG (2014) Bifidobacteria delivery and Infection Resistance: Bile acid modification in the gut. [Oral Presentation], Bifidobacteria: applications in infection, inflammation & cance, Summer School. Ulm University, Ulm, Germany , 28-JUL-14 - 01-AUG-14. [Details]
(2013)International Scientific Association for Probiotics and Prebiotics (ISAPP) meeting, New York Acad. Sci,
Gahan, CG (2013) Regulation of host weight gain and lipid metabolism by bacterial bile acid modification in the gut. [Oral Presentation], International Scientific Association for Probiotics and Prebiotics (ISAPP) meeting, New York Acad. Sci, New York , 12-JUN-13 - 14-JUN-13. [Details]
(2013)Driving the Pharmacy Research Agenda: Connecting the laboratory to the bedside,
Gahan, CG (2013) Bile, bacteria and energy metabolism: towards designer probiotics for weight management. [Oral Presentation], Driving the Pharmacy Research Agenda: Connecting the laboratory to the bedside, School of Pharmacy, University College Cork, Cork, Ireland , 27-SEP-14. [Details]
(2013)APC celebration of science and launch of next phase,
Gahan, CG (2013) Bugs and Bile Acids. Scientist of the year presentation. [Oral Presentation], APC celebration of science and launch of next phase, UCC Cork , 21-JUN-13. [Details]
(2013)ISOPOL (International Symposium on Problems of Listeriosis,
Gahan, CG (2013) Probiotics and listeriosis: lessons from the Listeria infection model. [Oral Presentation], ISOPOL (International Symposium on Problems of Listeriosis, Goa, India , 19-SEP-13 - 27-SEP-13. [Details]
(2013)Annual Public Lecture series,
Gahan, CG (2013) Modern antibiotic use: with great power comes great responsibility. [Oral Presentation], Annual Public Lecture series, UCC Cork , 06-MAR-13. [Details]
(2012)Hot Topics in Biomedical Science Research,
Gahan, CG (2012) Microbial bile salt hydrolase enzymes: functions in pathogens. [Oral Presentation], Hot Topics in Biomedical Science Research, NUI Galway , 29-JUN-12. [Details]
(2012)The 17th Conference (5th International) of the Medical Research Institute,
Gahan, CG (2012) The gastrointestinal microbiota, obesity and bile metabolism. [Oral Presentation], The 17th Conference (5th International) of the Medical Research Institute, Alexandria Egypt , 13-NOV-12 - 16-NOV-12. [Details]
(2012)Society for General Microbiolgy, UK General Meeting,
Gahan, CG (2012) Iron metabolism in Listeria monocytogenes: inside and outside the host. [Oral Presentation], Society for General Microbiolgy, UK General Meeting, Conference Centre, Dublin , 26-MAR-12 - 28-MAR-12. [Details]
(2012)Pharos University Seminar,,
Gahan, CG (2012) Gut microbiota and probiotic research. [Oral Presentation], Pharos University Seminar,, Alexandria, Egypt , 10-DEC-12. [Details]
(2011)Bayer Symposium on Microbiota,
Gahan, CG (2011) Trends in probiotics: targets and mechanisms of action. [Oral Presentation], Bayer Symposium on Microbiota, London , 27-NOV-11 - 28-NOV-11. [Details]
(2011)European Caliper Owners Group Meeting,
Gahan, CG (2011) Vectors for in vivo imaging of bacteria: pathogens and commensals. [Oral Presentation], European Caliper Owners Group Meeting, Leiden University, The Netherlands , 18-JUN-11. [Details]
(2011)Listeria surveillance network meeting. Teagasc,
Gahan, CG (2011) Listeria monocytogenes strain variation: are all strains equally pathogenic?. [Oral Presentation], Listeria surveillance network meeting. Teagasc, Moorepark, Fermoy , 16-MAY-11. [Details]
(2011)UK Caliper Owners Group Meeting,,
Gahan, CG (2011) Vectors for in vivo imaging of bacteria: pathogens and commensals. [Oral Presentation], UK Caliper Owners Group Meeting,, London , 15-SEP-11. [Details]
(2010)SGM Session. Cheltenham Science Festival,
Gahan, CG (2010) Breaking the GM taboo. [Oral Presentation], SGM Session. Cheltenham Science Festival, UK , 09-JUN-10 - 13-JUN-10. [Details]
(2009)Food Nutrition and Consumer Sciences,
Gahan, CG (2009) . An introduction to the Alimentary Pharmabiotic Centre. [Oral Presentation], Food Nutrition and Consumer Sciences, University College Cork , 03-AUG-09 - 04-AUG-09. [Details]
(2009)Trinity College Dublin Department of Microbiology Seminar Series,
Gahan, CG (2009) Microbial bile salt degradation in the human GI tract: from commensals to cheats and pathogens. [Oral Presentation], Trinity College Dublin Department of Microbiology Seminar Series, TCD , 06-MAR-09. [Details]
(2009)School of Pharmacy Seminar Series,
Gahan, CG (2009) . Beginning to see the light: Listeria pathogenesis and real-time imaging in the mouse. [Oral Presentation], School of Pharmacy Seminar Series, University of Brighton , 15-APR-09. [Details]
(2009)FEMS 2009 Microbiology Congress,
Broaders E, Gahan CG, Marchesi JR. Winner best poster; (2009) Investigation and characterisation of plasmid DNA from the healthy human gut. [Poster Presentation], FEMS 2009 Microbiology Congress, Gothenburg, Sweden , 28-JUN-09 - 02-JUL-09. [Details]
(2009)FEMS 2009 Microbiology Congress,
Dowd CG, Hill C and Gahan CG; (2009) Investigation of the molecular mechanisms by which Listeria monocytogenes grows in the mammalian gall bladder. [Poster Presentation], FEMS 2009 Microbiology Congress, Gothenburg, Sweden , 28-JUN-09 - 02-JUL-09. [Details]
(2009)FEMS 2009 Microbiology Congress,
McLaughlin, H, Sleator RD, Hill C and Gahan CG; (2009) Characterization of an MgtC-like Protein in L. monocytogenes EGDe. [Poster Presentation], FEMS 2009 Microbiology Congress, Gothenburg, Sweden , 28-JUN-09 - 02-JUL-09. [Details]
(2009)Invited Seminar,
Cormac GM Gahan; (2009) Beginning to see the light: bioluminescence imaging of bacterial infections. [Invited Seminars/Guest Lectures], Invited Seminar, School of Pharmacy, UCC , 15-DEC-09 - 15-DEC-09. [Details]
(2009)Invited Seminar,
Cormac GM Gahan; (2009) Bioluminescence imaging: a new research tool for visualising Listeria monocytogenes in vivo. [Invited Seminars/Guest Lectures], Invited Seminar, Department of Microbiology, NUI Galway , 04-DEC-09 - 04-DEC-09. [Details]
(2009)Invited Seminar,
Cormac GM Gahan; (2009) Microbial bile salt degradation in the human GI tract: from commensals to cheats and pathogens. [Invited Seminars/Guest Lectures], Invited Seminar, Department of Microbiology, Trinity College Dublin, , 06-MAR-09 - 06-MAR-09. [Details]
(2009)Invited seminar,
Cormac GM Gahan; (2009) Real-time bioluminescence imaging applications in models of microbial pathogenesis. [Invited Seminars/Guest Lectures], Invited seminar, School of Pharmacy, University of Brighton, UK , 15-APR-09 - 15-APR-09. [Details]
(2009)Society for General Microbiology,
Mohammed Bahey-El-Din, Pat G Casey, Brendan T Griffin and Cormac GM Gahan; (2009) Lactococcus lactis beyond the food industry: A promising delivery vector for antigens, immunomodulatory and therapeutic proteins. [Poster Presentation], Society for General Microbiology, University College Cork , 23-APR-09 - 24-APR-09. [Details]
(2009)All Ireland Schools of Pharmacy Conference,
Mohammed Bahey-El-Din, Pat G Casey, Brendan T Griffin and Cormac GM Gahan. ; (2009) Lactococcus lactis beyond the food industry: A promising delivery vector for antigens, immunomodulatory and therapeutic proteins. [Poster Presentation], All Ireland Schools of Pharmacy Conference, Ireland , 27-APR-09 - 27-APR-09. [Details]
(2009)Society for General Microbiology,,
Cormac GM Gahan; (2009) Functional and comparative metagenomic analysis of bile salt hydrolase activity in the human gut microbiome: pathogens & commensals. [Oral Presentation], Society for General Microbiology,, Harrogate, UK , 30-MAR-09 - 02-APR-09. [Details]
(2009)Conference on Listeria monocytogenes,
Cormac GM Gahan; (2009) Bioluminescence imaging: a new research tool for visualising Listeria in vivo. [Invited Oral Presentation], Conference on Listeria monocytogenes, Moorepark Food Research Centre , 21-SEP-09 - 22-SEP-09. [Details]
(2009)Conference on Listeria monocytogenes,
Cormac GM Gahan; (2009) Bioluminescence imaging: a new research tool for visualising Listeria in vivo. [Invited Oral Presentation], Conference on Listeria monocytogenes, Moorepark Food Research Centre , 21-SEP-09 - 22-SEP-09. [Details]
(2009)39th Annual research Conference, Food Nutrition and Consumer Sciences,,
Cormac GM Gahan; (2009) An introduction to the Alimentary Pharmabiotic Centre. [Invited Oral Presentation], 39th Annual research Conference, Food Nutrition and Consumer Sciences,, University College Cork , 03-SEP-09 - 04-SEP-09. [Details]
(2009)Society for General Microbiology (SGM) Irish Branch Meeting,
Gahan, CG (2009) Beginning to see the light: Listeria pathogenesis and real-time imaging in the mouse. [Oral Presentation], Society for General Microbiology (SGM) Irish Branch Meeting, Irish Branch Meeting , 23-APR-09 - 24-APR-09. [Details]
(2009)Society for General Microbiology,
Cormac GM Gahan; (2009) Beginning to see the light: Listeria pathogenesis and real-time imaging in the mouse. [Invited Oral Presentation], Society for General Microbiology, University College Cork , 23-APR-09 - 24-APR-09. [Details]
(2009)Society for General Microbiology,
Cormac GM Gahan; (2009) Real-time non-invasive monitoring of bacterial infections in vivo. [Invited Oral Presentation], Society for General Microbiology, Heriot-Watt University Edinburgh 7th-10th September 2009 , 07-SEP-09 - 10-SEP-09. [Details]
(2009)Society for General Microbiology,
Cormac GM Gahan; (2009) Real-time non-invasive monitoring of bacterial infections in vivo. [Invited Oral Presentation], Society for General Microbiology, Heriot-Watt University Edinburgh 7th-10th September 2009 , 07-SEP-09 - 10-SEP-09. [Details]
(2009)NUI Galway Department of Microbiology Seminar Series,
Gahan, CG (2009) Bioluminescence imaging: a new tool for visualizing Listeria monocytogenes in vivo. [Oral Presentation], NUI Galway Department of Microbiology Seminar Series, NUI Galway , 04-DEC-09. [Details]
(2009)School of Pharmacy Seminar Series,
Gahan, CG (2009) Bioluminescence imaging of bacterial infections. [Oral Presentation], School of Pharmacy Seminar Series, UCC Cork , 15-DEC-09. [Details]
(2008)University of Cardiff School of Medicine Seminar Series,
Gahan, CG (2008) Microbial bile salt degradation in the human GI tract: from commensals to cheats and pathogens. [Oral Presentation], University of Cardiff School of Medicine Seminar Series, University of Cardiff , 04-DEC-08. [Details]
(2008)The 7th Annual Meeting of the Irish Epithelial Physiology Group,
Gahan CG* and Joyce SA (2008) Bile acid modifications at the microbe-host interface. [Oral Presentation], The 7th Annual Meeting of the Irish Epithelial Physiology Group, NewPark Hotel, Kilkenny, Ireland , 23-OCT-14 - 14-OCT-14. [Details]
(2007)Pseudomonas 2007,
O'callaghan, J. and Mulcahy, H. and Casey, P. and Baysse, C. and O'grady, EP and Hill, C. and Adams, C. and Gahan, C. and O'gara, F. (2007) Comparative analysis of Pseudomonas aeruginosa strains, altered in their ability to cause acute infection, in response to bronchial epithelial cells. [N/A], Pseudomonas 2007, Seattle . [Details]

Committees

 CommitteeFunctionFrom / To
Research & Graduate Studies Pharmacy Chair/
Research Committee Microbiology Member/
Research Quality Review Committee Microbiology Member/
Seminar Series Co-ordinator Microbiology Co-ordinator/
Microbe-Host Interactions UREKA Site Co-ordinator/

Employment

 EmployerPositionFrom / To
University College Cork Post-Doctoral Researcher02-JAN-95 / 01-JAN-97
University College Cork HRB Post-Doctoral Fellow01-JAN-98 / 01-JAN-02
University College Cork Temporary Lecturer01-SEP-02 / 01-SEP-04
University College Cork Lecturer (Above the bar)01-SEP-04 /

Education

 YearInstitutionQualificationSubject
1990University College Cork BSCUnknown
1996University College Cork PHDUnknown
2011University College Cork Postgraduate Cert in Higher EducationTeaching & Learning

Outreach Activities

 Description

Outreach activities through the Alimentary Pharmabiotic Centre (http://apc.ucc.ie) include: School visits, School lectures (leaving cert), UREKA Microbe-Host Interactions Site

Other Activities

 Description

Recent Seminar/Conference Presentations (*Indicates Presenting Author) Invited Oral Presentations (* presenting author) Gahan CG* and Joyce SA* (two presenters). 2014. Bile acid modifications at the microbe-host interface. The 7th Annual Meeting of the Irish Epithelial Physiology Group. NewPark Hotel, Kilkenny, Ireland. 23rd-24th October 2014. Gahan CG*. 2014. Bifidobacteria delivery and Infection Resistance: Bile acid modification in the gut. Bifidobacteria: applications in infection, inflammation & cancer. Summer School. Ulm University, Ulm, Germany. 28th July-1st August 2014. Gahan CG*. 2014. Hot Topic: Regulation of host metabolism by bacterial bile acid modification in the gut. International Scientific Association for Probiotics and Prebiotics (ISAPP) meeting, ROWETT/INRA/ISAPP joint meeting. Aberdeen, UK. June 18-20, 2014. Gahan CG*. 2014. BioMedical Applications in Synthetic Microbiology. The Synthetic Biology Future: SynBio International Conference. County Hall, Cork, Ireland. 13th March 2014. Gahan CG*. 2013. Bile, bacteria and energy metabolism: towards designer probiotics for weight management. Driving the Pharmacy Research Agenda: Connecting the laboratory to the bedside. School of Pharmacy, University College Cork, Cork, Ireland. 27th September 2013. Gahan CG*. 2013. Probiotics and listeriosis: lessons from the Listeria infection model. ISOPOL (International Symposium on Problems of Listeriosis), Goa, India. 19th-22nd September 2013. Gahan CG*. 2013. Bugs and Bile Acids. Scientist of the year presentation. APC celebration of science and launch of next phase. University College Cork, Cork. June 21st 2013. Gahan CG*. 2013. Regulation of host weight gain and lipid metabolism by bacterial bile acid modification in the gut. International Scientific Association for Probiotics and Prebiotics (ISAPP) meeting, New York Acad. Sci, New York, 12th-14th June 2013. Gahan CG*. 2013. Modern antibiotic use: with great power comes great responsibility. Annual Public Lecture series (2013), University College Cork, Cork, Ireland. 6th March 2013. Gahan CG*. 2012. Gut microbiota and probiotic research. Pharos University Seminar, Alexandria, Egypt. 10th December 2012. Gahan CG*. 2012. The gastrointestinal microbiota, obesity and bile metabolism. The 17th Conference (5th International) of the Medical Research Institute Alexandria University. Advances in Medical Research OBESITY. Alexandria, Egypt. 13th-16th November 2012. Gahan CG*. 2012. Microbial bile salt hydrolase enzymes: functions in pathogens, commensals and beyond. Hot Topics in Biomedical Science Research. NUI Galway. 29th June 2012. Gahan CG*. 2012. Iron metabolism in Listeria monocytogenes: inside and outside the host. Society for General Microbiolgy, UK General Meeting, Conference Centre, Dublin. 26th-28th March 2012. Gahan CG*. 2011. Trends in probiotics: targets and mechanisms of action. Bayer Symposium on Microbiota. London 27th-28th October 2011. Gahan CG*. 2011. Vectors for in vivo imaging of bacteria: pathogens and commensals. UK Caliper Owners Group Meeting, London 15th September 2011. Gahan CG*. 2011. Vectors for in vivo imaging of bacteria: pathogens and commensals. European Caliper Owners Group Meeting, 6th European Molecular Imaging Conference, Leiden University, The Netherlands 18th June 2011. Gahan CG*. 2011. Listeria monocytogenes strain variation: are all strains equally pathogenic? Listeria surveillance network meeting. Teagasc Moorepark, Fermoy. 16th May 2011. Gahan CG*. 2010. Breaking the GM taboo. SGM Session. Cheltenham Science Festival. 9th-13th June 2010 Gahan CG*. 2009. Bioluminescence imaging of bacterial infections. School of Pharmacy Seminar Series, University College Cork. 15th December 2009. Gahan CG*. 2009. Bioluminescence imaging: a new tool for visualizing Listeria monocytogenes in vivo. NUI Galway Department of Microbiology Seminar Series. 4th December 2009. Gahan CG*. 2009. Bioluminescence imaging: a new research tool for visualising Listeria in vivo. Conference on Listeria monocytogenes, Moorepark Food Research Centre, 21st-22nd September, 2009. Gahan CG*. 2009. Real-time non-invasive monitoring of bacterial infections in vivo. Society for General Microbiology, Heriot-Watt University Edinburgh 7th-10th September 2009. Gahan CG*. 2009. An introduction to the Alimentary Pharmabiotic Centre. 39th Annual research Conference, Food Nutrition and Consumer Sciences, University College Cork, 3rd-4th September 2009. Gahan CG*. 2009. Beginning to see the light: Listeria pathogenesis and real-time imaging in the mouse. University of Brighton, School of Pharmacy Seminar Series. 15th April 2009. Gahan CG*. 2009. Beginning to see the light: Listeria pathogenesis and real-time imaging in the mouse. Society for General Microbiology (SGM) Irish Branch Meeting. 23rd- 24th April 2009. Gahan CG*. 2009. Microbial bile salt degradation in the human GI tract: from commensals to cheats and pathogens. Trinity College Dublin Department of Microbiology Seminar Series. 6th March 2009. Gahan CG*. 2008. Microbial bile salt degradation in the human GI tract: from commensals to cheats and pathogens. University of Cardiff School of Medicine Seminar Series. 4th December 2008. Gahan CG*. 2007. Seminar: Beginning to see the light: bioluminescence imaging applications in Listeria monocytogenes, The Royal Veterinary & Agricultural University, Copenhagen, Denmark. 29th November 2007. Gahan CG*. 2007. Listeria monocytogenes: acid stress responses in foods and beyond. Society for General Microbiology 160th Meeting, University of Manchester, 26th-29th March 2007. Gahan CG*. 2006. Seminar: Pathogenesis of foodborne pathogens – adaptation within complex systems, University of Dijon, 7th December 2006. Gahan CG*. 2006. Seminar: Pathogenesis of foodborne pathogens – adaptation within complex systems, Stanford University School of Medicine seminar, 10th October 2006 Gahan CG*. 2004. The gastrointestinal phase of Listeria monocytogenes infection. Society for Applied Microbiology Summer Conference, Jury’s Hotel Cork. 12th-15th July 2004. Gahan CG*. Mining the gut flora for novel therapeutics. SFI-IBIA Research Networking Event, Dublin. 12th November 2004. Gahan CG*. 2004. Identifying genetic loci responsible for bile resistance and pathogenesis of Listeria monocytogenes. NUI Galway Department of Microbiology Seminar Series. 16th January 2004. Offered Oral presentations (including student presentations) (* presenting author) Nolan J*, Gahan CG, Hill C, Joyce SA et al. 2014. Rosuvastatin significantly alters the community structure of the murine gastrointestinal microbiota. College of Medicine & Health Annual Research Day. Food, Microbes and Molecular Medicine. University College Cork, Cork, Ireland. 18th June 2014. Gahan CG*. 2012. Escherichia coli MG1655 as a model delivery vehicle to study host commensalism. International Scientific Conference on Probiotics and Prebiotics Košice, Slovakia. 12th-15th June 2012. Gahan CG*, Jones, BV, Begley, M, Hill, C, Marchesi J. 2009. Functional and comparative metagenomic analysis of bile salt hydrolase activity in the human gut microbiome: pathogens & commensals. SGM UK Meeting Harrogate. 30th April-2nd March 2009. Bahey-el-din M*, Casey PG, Griffin BT and CG Gahan. 2009. Lactococcus lactis beyond the food industry: A promising delivery vector for antigens, immunomodulatory and therapeutic proteins. All Ireland Schools of Pharmacy meeting. Trinity College Dublin, Ireland. 26-27th March 2009. Bahey-el-din M*, Griffin BT and CG Gahan. 2008. From Yoghurt to vaccine development: Lactococcus lactis as a live vaccine vector against Listeriosis. All Ireland Schools of Pharmacy Meeting. University College Cork, Cork, Ireland. 3rd-4th April 2008. Gahan CG*. Jones, BV, Begley, M, Hill, C, Marchesi J. 2008. Evolution of bile acid modification in the human gut microbiome. Gut Microbiology; INRA-Rowett Conference, Clermont-Ferrand, France. 18th-20th June, 2008. Begley, M*, Heuston, S, Bron, P, Jomaa, H, Gahan, CGM and C Hill. 2008. Analysis of isoprenoid biosynthesis pathways in Listeria monocytogenes. Gut Microbiology; INRA-Rowett Conference, Clermont-Ferrand, France. 18th-20th June, 2008. Begley, M*, Jones, BV, Hill, C, Gahan, CGM and J. Marchesi. 2008. Metagenomic analysis of intestinal BSH activity. LAB 9, 9th Symposium on Lactic Acid Bacteria, Health, Evolution and Systems Biology. Egmond aan Zee, Holland, 30th Aug – 4th Sept, 2008. Heuston, S*, Gahan CGM and C Hill. 2008. Analysis of the isoprenoid biosynthesis pathways in Listeria reveals a role for the alternative MEP pathway in murine infection. Society for General Microbiology Irish Branch Meeting, National University of Ireland, University College Galway, 27th - 28th March 2008 Sinead won second prize for best oral presentation. Corr, SC* Hill C and Gahan CGM. 2007. Probiotics as anti-infectives: protecting against Listeria infection through bacteriocin production. Irish Soc of Gastroenterology. Spring Meeting Killarney, 19-20th April, 2007. Winner Best Oral Presentation. Corr, SC*, Li Y, O’Toole P, Gahan CGM, Hill, C. 2007. Probiotics as anti-infectives: protecting against Listeria infection through bacteriocin production. Society for General Microbiology, 161st Meeting, Edinburgh, Scotland, September 3-6th 2007. Represented Irish SGM in Student Awards. Finished in second position in UK & Ireland overall competition. Corr SC; Gahan CG et al. 2007. Induction of epithelial cell CCL20 by Listeria monocytogenes is dependent upon entry to the host cell cytosol. Digestive Disease Week, Washington DC, USA, 19th-24th May, 2007 Corr, SC*, Hill, C and Gahan CGM. 2006. An in vitro cell-culture model shows internalin- and hemolysin-independent translocation of Listeria monocytogenes across M cells. SGM Irish Branch Meeting, TCD, April 27-28th, 2006. Winner best student presentation. Corr, S*, Hill, C and Gahan CG. 2006. Probiotic bacteria impede Listeria monocytogenes infection and modulate the mucosal immune response. Fifth joint RRI-INRA Gastrointestinal Tract Microbiology Symposium. 21-23 June, 2006, Aberdeen, Scotland. Joint-Winner, Best Oral Student Presentation. Gahan CGM* and C Hill. 2004. Links between stress tolerance and gastrointestinal persistence of Listeria monocytogenes. International Symposium on problems of Listeriosis (ISOPOL), Uppsala, Sweden 12th-15th September 2004 Monk IR*, Cook GM, Bremer PJ, Monk BC, Gahan CGM and C Hill. 2004. Morphotypic variation in Listeria monocytogenes biofilms. International Symposium on problems of Listeriosis (ISOPOL), Uppsala, Sweden 12th-15th September 2004 Rea R*, Hill C and CGM Gahan. 2004. Dissecting the Fur regulon in Listeria monocytogenes: role of Fur-regulated genes in growth under iron-limiting conditions and during murine infection. International Symposium on problems of Listeriosis (ISOPOL), Uppsala, Sweden 12th-15th September 2004

Recent Poster presentations (* presenting author) Morgan CA*, Hill C and CG Gahan. 2014. Functional characterisation of virulence potential in Irish Listeria monocytogenes strains. Imperial College London / University College Cork joint symposium. Imperial College London, UK. 24th-26th September 2014. Joyce SA*, Govindarajan K, Connelly C, Kinsella M, Casey PG, Hill C and CG Gahan. 2014. Bile salt signalling adjustment and inferred impact on signalling by the pathogen Listeria monocytogenes. Exploring human host-microbiome interactions in health and disease, Welcome Trust Scientific Conference, Welcome Trust Genome Campus, Hinxton, UK. 14th-16th April 2014. Hanin A*, Culligan E, Hill C and CG Gahan. 2012. Enabling oral delivery of prophylactic molecules by modifying the colonisation ability of Lactococcus lactis. Young Microbiologists Symposium on Microbial Signalling, Organisation & Pathogenesis. SGM, University College Cork, Cork, Ireland. 21st-22nd June 2012. Nolan J, Hill C and CG Gahan. 2012. The effects of Rosuvastatin on bacterial viability and growth: targeting the mevalonate pathway of isoprenoid biosynthesis. Young Microbiologists Symposium on Microbial Signalling, Organisation & Pathogenesis. SGM, University College Cork, Cork, Ireland. 21st-22nd June 2012. CGM Gahan*, Joyce S, Casey PG, Hill C and GC Dowd. 2011. Investigation of the mechanisms underpinning bacterial gall bladder infection: the Listeria monocytogenes model. International Union of Microbiological Societies (IUMS) Congress. Sapporo, Japan. 6th-10th September 2011. Dowd G, Joyce S, Hill C and CGM Gahan*. 2011. Investigation of the mechanisms underpinning bacterial gall bladder infection: the Listeria monocytogenes model. FEMS Congress, Geneva. 26th-30th June 2011. Winner Best Poster, Day 2 Cummins J* and CG Gahan. 2011. Development of a murinized Listeria monocytogenes strain for improved murine infection. FEMS Congress, Geneva. 26th-30th June 2011. Dowd G, Joyce S, Hill C and CGM Gahan*. 2010. Investigation of the molecular mechanisms by which Listeria monocytogenes grows in the mammalian gall bladder. International Symposium on Problems of Listeriosis (ISOPOL), Porto, Portugal 5th-8th May 2010. Joyce SA and CG Gahan. 2010. Listeria infection of the insect model system Galleria mellonella. International Symposium on Problems of Listeriosis (ISOPOL), Porto, Portugal 5th-8th May 2010. Cummins J* and CG Gahan. 2010. Development of a murinized Listeria monocytogenes strain for improved murine infection. International Symposium on Problems of Listeriosis (ISOPOL), Porto, Portugal 5th-8th May 2010. Bahey-el-din M*, Casey P, Griffin BT and CG Gahan. 2009. Lactococcus lactis, from food industry to antigen delivery: A potential vaccine vector against Listeria monocytogenes infection. Society for General Microbiology (SGM) Irish Branch Meeting. UCC, Cork, Ireland. 23rd- 24th April 2009. Casey PG*, Gahan CG and C Hill. 2009. Lightening your load: the use of bioluminescence technology in designing more efficient in vivo virulence experiments. Society for General Microbiology (SGM) Irish Branch Meeting. UCC, Cork, Ireland. 23rd- 24th April 2009. Dowd G, Joyce S, Hill C and CGM Gahan*. 2009. Investigation of the molecular mechanisms by which Listeria monocytogenes grows in the mammalian gall bladder. Science Foundation Ireland Summit 2009. Hodson Bay Hotel, Athlone. 9th-10th November 2009. Broaders E*, Gahan CG and J Marchesi. 2009. Investigation and characterization of plasmid DNA from the healthy human gut. FEMS Congress. Gothenburg, Sweden. 28th June to 2 nd July 2009. Dowd G*, Hill C and CG Gahan. 2009. Investigation of the molecular mechanisms by which Listeria monocytogenes grows in the mammalian gall bladder. FEMS Congress. Gothenburg, Sweden. 28th June to 2 nd July 2009. McLaughlin H*, Hill C and CG Gahan. 2009. Characterization of an MgtC-like Protein in L. monocytogenes EGDe. FEMS Congress. Gothenburg, Sweden. 28th June to 2nd July 2009. Bahey-el-din M*, Casey PG, Griffin BT and CG Gahan. 2009. Lactococcus lactis, from food industry to antigen delivery: A potential vaccine vector against Listeria monocytogenes infection. Translational Health Research Conference. College of Medicine and Health, UCC, Cork, Ireland. June 24th 2009 Jones, BV, Begley M, Hill, C, Marchesi, JR and CGM Gahan*. Functional metagenomic analysis of bile acid degradation in the human gut microbiota: evolution from commensals to cheats and pathogens. Irish Society of Gastroenterology, Spring Meeting, Sligo Clarion, 24th-25th April, 2008. Begley, M*, Jones, BV, Hill, C, Gahan, CGM and J. Marchesi. Functional and comparative metagenomic analysis of BSH activity in the human gut microbiome. LAB 9, 9th Symposium on Lactic Acid Bacteria, Health, Evolution and Systems Biology. Egmond aan Zee, Holland, 30th Aug – 4th Sept, 2008. *Maire Begley was chosen for an oral presentation and won best poster of almost 600 posters. Dowd G*, Hill C and CG Gahan. 2008. The role of Zur in regulating environmental stress resistance and virulence potential in Listeria monocytogenes. Society for General Microbiology (SGM) Irish Branch Meeting. NUIGalway, Galway, Ireland. 23rd- 24th April 2008. McLaughlin H*, Sleator RD, Rea R, Hill C and CG Gahan. 2008. Iron acquisition, an essential feature of Listeria monocytogenes infection. Society for General Microbiology (SGM) Irish Branch Meeting. NUIGalway, Galway, Ireland. 23rd- 24th April 2008. Riedel C, Begley M, Sleator RD, Monk IR, Bron P, Watson D, Dowd G, Casey PG, Joyce S, Hill C and CG Gahan*. Gastrointestinal pathogenesis of Listeria monocytogenes; bile tolerance, gall bladder infection and asymptomatic carriage. Science Foundation Ireland Science Summit 2007. Citywest Hotel, Dublin. 26th-28th November, 2007 Begley, M*, Kerr, C, Stack, H, Gahan, CGM and C. Hill. 2008. A Hitchhikers guide to the gut; lessons learned from Listeria monocytogenes infection. Society for General Microbiology Irish Branch Meeting, National University of Ireland, University College Galway, 27th - 28th March 2008 McLaughlin, H*, Sleator, RD, Rea, R, Hill, C and CGM Gahan. Iron acquisition, an essential feature of Listeria monocytogenes infection. Society for General Microbiology Irish Branch Meeting, National University of Ireland, University College Galway, 27th - 28th March 2008 Dowd, G*, Hill, C and CGM Gahan. The role of Zur in regulating environmental stress resistance and virulence potential in Listeria monocytogenes. Society for General Microbiology Irish Branch Meeting, National University of Ireland, University College Galway, 27th - 28th March 2008 Heuston, S*, Begley, M, Bron, P, Gahan CGM and C Hill. Analysis of the isoprenoid biosynthesis pathways in Listeria reveals a role for the alternative MEP pathway in murine infection. Society for General Microbiology Irish Branch Meeting, National University of Ireland, University College Galway, 27th - 28th March 2008 Corr, SC*, O'Hara, A, O'Mahony, L, Nally, K, Shanahan, F, Hill, C and CG Gahan. Mechanism of Epithelial CCL20 Response to Listeria. Digestive Disease Week, San Diego, California, May 17-22, 2008 Heuston, S*, Begley, M, Bron, P, Gahan, CGM and C Hill. 2007. Analysis of isoprenoid biosynthesis pathways in Listeria monocytogenes. Irish Society of Gastroenterology Winter meeting, Clontarf, Dublin. 29th-30th Nov 2007 Riedel, C*, Monk, IR, Casey, PG, Gahan CG and C Hill. Role of agrD for biofim formation and virulence in L. monocytogenes. DGHM, Gottingen, Germany, 30th Sept-4th Oct 2007. Casey PG*, Hill C, Gahan CG. Lightening your load: the use of bioluminescence technology in designing more efficient in vivo virulence experiments. 2nd International Clostridium difficile Symposium, Maribor, Slovenia. June 6th - 9th, 2007 Deegan L*, Sexton R, Monk I, Hill C and Gahan CGM. Putative cell wall associated proteins which may aid in the adherence of Clostridium difficile to the colonic epithelium. 2nd International Clostridium difficile Symposium, Maribor, Slovenia, June 6th-9th 2007 McLaughlin H*, Sleator RD, Rea R, Hill C and Gahan CGM. Iron acquisition, an essential feature of Listeria monocytogenes infection’ Society for General Microbiology, 161st Meeting, Edinburgh, Scotland, September 3-6th 2007 Dowd G*, Hill C and Gahan CGM. The role of Zur in regulating environmental stress resistance and virulence potential in Listeria monocytogenes. Society for General Microbiology, 161st Meeting, Edinburgh, Scotland, September 3-6th 2007 Heuston S*, Bron P, Begley M, Eberl M, Jomaa H, Gahan CGM, Hill C. Two Pathways of IPP Biosynthesis in Listeria monocytogenes influence Vγ9/Vδ2 T-Cell Activation. Keystone Symposia, Regulatory T cells, Vancouver, Canada, Feb 1st-6th, 2007 Watson, D*, Sleator RD, Hill C and Gahan CGM. Harnessing stress response systems to enhance Bifidobacteria survival and persistence in the gastrointestinal tract. 2nd International symposium on Propionibacteria and Bifidobacteria: dairy and probiotic applications, Wadahl, Norway, June 2007

Journal Activities

 JournalRoleTo / From
Applied And Environmental Microbiologyapplied And Environmental Microbiology Member of Editorial Board-

Teaching Interests

Recent Postgraduates

 Graduation YearStudent NameInstitutionDegree TypeThesis Title
2015James Nolan UCCPHD
2012Neasa O Leary Wallace UCCMSc
2012Eileen Broaders UCCPHDInvestigating Mobile Genetic Elements in the Human Gut Environment
2011Sinead Heuston UCCPHDMolecular Analysis of Isoprenoid Biosynthetic Pathways in Listeria monocytogenes
2011Georgina Dowd UCCPHD
2010Heather McLaughlin UCCPHD
2010Bahey El-Din UCCPHD
2009Debbie Watson UCCPHD
2008Lynn Naughton UCCPHD
2008Ian Monk UCCPHD
2007Sheila Ryan UCCPHD
2007Eleanor Ryan UCCMSc
2007Helena Stack UCCPHD

Current Postgraduate Students

 StudentDegree Type
Nolan James Anthony Doctoral Degree
Leong Dara Doctoral Degree
Morgan Ciara Amy Doctoral Degree

Modules Taught

 Term (ID))TitleLinkSubject
2015Advanced Immunology MB4009Advanced Immunology
2015Advanced Medical Microbiology MB4007Advanced Medical Microbiology
2015Literature Project on Genetics GN3002Literature Project on Genetics
2015Research Project MB4002Research Project
2015Research Frontiers in Microbiology MB4027Research Frontiers in Microbiology
2015Biopharmaceuticals: Formulation Design, Secondary Processing and Regulatory compliance PF6301Biopharmaceuticals: Formulation Design, Secondary Processing and Regulatory compliance
2015Clinical Microbiology PF3444Clinical Microbiology
2015Microbiology MB2444Microbiology
2015Research Dissertation MB6303Research Dissertation
2015Research Frontiers in Food Microbiology MB6027Research Frontiers in Food Microbiology