Senior Lecturer
Microbiology
University College Cork
Cork
Ireland

T: +353-21-490-3000
F: +353 21 490 1363
E: C.Gahan@ucc.ie
W: http://www.ucc.ie/
Senior Lecturer
Microbiology
School of Microbiology
& School of Pharmacy
University College Cork

T: +353 21 490 1363
F: +353 21 490 3101
E: C.Gahan@ucc.ie

Overview

Dr. Cormac Gahan graduated in 1996 with a PhD in Immunology and Microbiology from University College Cork. He has since published over 90 peer-reviewed articles and book chapters in journals including PNAS, Molecular Microbiology, Infection and Immunity, Vaccine and Journal of Bacteriology. His current h-index is 34. Recent work has examined the use of live L. monocytogenes and L. lactis vectors as gene and protein delivery platforms for novel vaccination and therapeutic approaches. This work has been carried out in collaboration with Dr. Mark Tangney at the Cork Cancer Research Centre and Dr. Brendan Griffin in the School of Pharmacy, UCC. Dr. Gahan leads the Infectious Disease programme with Prof. Colin Hill within the Alimentary Pharmabiotic Centre (Globe iconhttp://apc.ucc.ie ) and is funded by further grants from Science Foundation Ireland and the Health Research Board.

Dr. Gahan is currently on the Editorial Board of the Journal of Pathogens andApplied and Environmental Microbiology and was on the editorial board of Journal of Applied Microbiology & Letters in Applied Microbiology from 2004-2010.  Dr. Gahan directed the SFI funded UREKA programme entitled Microbe-Host Interactions that provided laboratory training for undergraduate students (Globe iconhttp://ureka.ucc.ie ) from 2006-2011.

 Academic Career

1986-1990: BSc

1990-1995: PhD Immunology & Microbiology

Additional Positions and Awards

1995-1998: Postdoctoral Researcher, Department of Microbiology, UCC

1998-2001: Health Research Board Postdoctoral Research Fellow, UCC

2001-2003: Principal Investigator, Listeria pathogenesis, UCC

2002-2004: Temporary Lecturer, Department of Microbiology, UCC

2004-Present: Faculty Appointment, School of Pharmacy & Department of Microbiology, UCC

2006: Enterprise Ireland International Collaboration Award to visit collaborators (Dr. Jonathan Hardy and Prof. Chris Contag) at Stanford University Medical School

2006-Present: Director of UREKA undergraduate research programme (Microbe-Host Interactions, UCC) funded by SFI

2005-Present: Member of editorial board of Journal of Applied Microbiology and Letters in Applied Microbiology

Teaching areas

  • Microbiology – an Introduction for Pharmacy Students (MB2444)
  • Clinical Microbiology for Pharmacy Students (PF3444)
  • Advanced Medical Microbiology (MB4007)
  • Advanced Immunology (MB4009)
  • Pharmaceutical Biotechnology (PF4109 & PF6205)
  • Pharmaceutical Microbiology & Sterile Manufacturing (PF6203)

Research interests and expertise

  • Development of live bacterial vaccine and DNA delivery vectors
  • Understanding microbial pathogenesis in gut pathogens (Listeria monocytogenes & Clostridium difficile)
  • Culture-independent approaches to understanding the gut microbiota
  • Microbe-host signaling and bile degradation in the human GI tract

Research Overview

My research group is dedicated to understanding the microbial pathogenesis of specific gut pathogens (in particular Listeria monocytogenes and Clostridium difficile). A complete understanding of the mechanisms governing host-pathogen interactions in the GI tract can be used to inform vaccine or DNA delivery strategies, to combat infections or to exploit the unique properties of these organisms as live vectors for the delivery of novel therapeutics. For example in collaboration with Dr. Mark Tangney at the Cork Cancer Research Centre we have recently exploited attenuated L. monocytogenes as a gene delivery vehicle for targeting tumour cells (van Pijkeren et al, 2010, Human Gene Therapy). In addition, benign L. lactis bacteria can be used to express a protein from L. monocytogenes that improves the ability of the organism to act as a vaccine delivery vector (Bahey-el-din et al., 2008, Vaccine). L. monocytogenes shares much in common with normal harmless bacteria that reside as commensals in the human GI tract. We have recently utilized culture-independent approaches (metagenomics) to examine one such activity (bile salt hydrolase) that is abundant throughout the entire population of organisms in the GI tract (Jones et al., 2008, Proceedings of the National Academy of Sciences). This metagenomics approach is currently being expanded in order to identify potentially novel therapeutics from the gut microbiota.

Key Publications:

van Pijkeren JP, Morrissey D, Cronin M, Rajendran S, O’Sullivan G, Gahan CG*, Tangney M. 2010. A novel Listeria monocytogenes-based system for cancer gene therapy. Human Gene Therapy. 21(4):405-16

Tangney M, Gahan CG. 2010. Listeria monocytogenes as a vector for anti-cancer therapies. Current Gene Therapy. 10(1):46-55.

Bahey-el-din M, Casey PG, Griffin BT, Gahan CG. 2010. Efficacy of a Lactococcus lactis delta-pyrG vaccine delivery platform expressing chromosomally integrated hly from Listeria monocytogenes. BioEngineered Bugs. 1(1):66-74.

Bahey-El-Din M, Casey PG, Griffin BT and CGM Gahan. 2008. Lactococcus lactis expressing Listeriolysin O (LLO) provides protection and specific CD8+ T cells against Listeria monocytogenes in the murine infection model. Vaccine. 26(41):5311-21.

Jones BV, Begley M, Hill C, Gahan CGM*, Marchesi JR. 2008. Functional and comparative metagenomic analysis of bile salt hydrolase activity in the human gut microbiome. Proc Natl Acad Sci U S A. 105(36):13580-5.

Corr SC, Li Y, Riedel CU, O’Toole PW, Hill C, Gahan CGM. 2007. (From the cover) Bacteriocin production as a mechanism for the anti-infective activity of Lactobacillus salivarius UCC118. Proc. Natl. Acad. Sci. (USA). 104(18): 7617-7621.

Research funding and grants
• IRCSET Post-graduate Research Fellowship (to James Nolan), (2010-2013)
• SFI Research Frontiers Programme Grant, (2008-2011) Functional genetic analysis of Listeria monocytogenes infection of the GI tract 08/RFP/GEN1320
• SFI CSET , the Alimentary Pharmabiotic Centre, UCC, (2008-2013), co-leader of the Pathogenicity Programme (with Prof. Colin Hill) and one of 22 principal investigators associated with the scientific research programme. For details see http://apc.ucc.ie
• Microbe-Host Interactions UREKA Site for Undergraduate Research projects, (2009-2011), SFI. 09/UR/B1527. For details see http://ureka.ucc.ie
• SFI Research Frontiers Programme Grant ,‘ Listeria monocytogenes as a vector for cancer gene therapy', (2007-2008), co-leader with Dr. Mark Tangney (lead applicant)
• IRCSET Post-graduate Research Fellowship (to Sinead Heuston), (2006-2009) with Prof. Colin Hill (co-supervisor)
• IRCSET Post-graduate Research Fellowship (to Heather McLaughlin), (2006-2009) with Prof. Colin Hill (co-supervisor)
• TRAMWAYS: Transfer of knowledge in microbial signal transduction pathways and metagenomics', European Union, Marie-Curie Host Fellowships for the Transfer of Knowledge (TOK) Development Host Schemes, (2007-2009) with members of the Department of Microbiology (lead applicant is Prof. Alan Dobson).
• Exploitation of in vivo -induced antigen technology (IVIAT) in Clostridium difficile: a rational approach to vaccine development, HRB Research Project Grant , (2006-2009)
• RP/2006/23SFI Research Frontiers Programme Grant, (2005-2008) The influence of bile tolerance on the pathogenesis and immunogenicity of Listeria monocytogenes , 05/RFP/GEN022

Peer Reviewed Journals

 YearPublication
(2013)'Virulence aspects of Listeria monocytogenes LO28 high pressure-resistant variants'
Van Boeijen IK, Casey PG, Hill C, Moezelaar R, Zwietering MH, Gahan CG, Abee T (2013) 'Virulence aspects of Listeria monocytogenes LO28 high pressure-resistant variants'. Microbial Pathogenesis, 59-60 :48-51 [DOI] [Details]
(2013)'Influence of internalin A murinisation on host resistance to orally acquired listeriosis in mice'
Bergmann S, Beard PM, Pasche B, Lienenklaus S, Weiss S, Gahan CG, Schughart K, Lengeling A (2013) 'Influence of internalin A murinisation on host resistance to orally acquired listeriosis in mice'. BMC Microbiology, 13 [DOI] [Details]
(2013)'Mobile genetic elements of the human gastrointestinal tract: potential for spread of antibiotic resistance genes'
Broaders E, Gahan CG, Marchesi JR (2013) 'Mobile genetic elements of the human gastrointestinal tract: potential for spread of antibiotic resistance genes'. Gut microbes, 4 (4):271-280 [DOI] [Details]
(2013)'A mariner transposon-based signature-tagged mutagenesis system for the analysis of oral infection by Listeria monocytogenes'
Cummins J, Casey PG, Joyce SA, Gahan CG (2013) 'A mariner transposon-based signature-tagged mutagenesis system for the analysis of oral infection by Listeria monocytogenes'. Plos One, 8 (9) [DOI] [Details]
(2013)'A mutant in the Listeria monocytogenes Fur-regulated virulence locus (frvA) induces cellular immunity and confers protection against listeriosis in mice'
McLaughlin, HP,Bahey-El-Din, M,Casey, PG,Hill, C,Gahan, CGM (2013) 'A mutant in the Listeria monocytogenes Fur-regulated virulence locus (frvA) induces cellular immunity and confers protection against listeriosis in mice'. Journal of Medical Microbiology, 62 :185-190 [DOI] [Details]
(2012)'The bacterial lux reporter system: applications in bacterial localisation studies'
Gahan CG (2012) 'The bacterial lux reporter system: applications in bacterial localisation studies'. Current Gene Therapy, 12 (1):12-19 [Details]
(2012)'A mutant in the Listeria monocytogenes Fur-regulated virulence locus (frvA) induces cellular immunity and confers protection against listeriosis in mice'
McLaughlin HP, Bahey-El-Din M, Casey PG, Hill C, Gahan CG (2012) 'A mutant in the Listeria monocytogenes Fur-regulated virulence locus (frvA) induces cellular immunity and confers protection against listeriosis in mice'. Journal of Medical Microbiology, [DOI] [Details]
(2012)'Signature tagged mutagenesis in the functional genetic analysis of gastrointestinal pathogens'
Cummins J, Gahan CG (2012) 'Signature tagged mutagenesis in the functional genetic analysis of gastrointestinal pathogens'. Gut, 3 (2):93-103 [DOI] [Details]
(2012)'Isoprenoid biosynthesis in bacterial pathogens'
Heuston S, Begley M, Gahan CG, Hill C (2012) 'Isoprenoid biosynthesis in bacterial pathogens'. Microbiology (Reading, England), 158 (Pt 6):1389-1401 [DOI] [Details]
(2012)'Investigation of the role of ZurR in the physiology and pathogenesis of Listeria monocytogenes'
Dowd, G.C. and Casey, P.G. and Begley, M. and Hill, C. and Gahan, C.G.M. (2012) 'Investigation of the role of ZurR in the physiology and pathogenesis of Listeria monocytogenes'. Fems Microbiology Letters, [Details]
(2012)'HmgR, a key enzyme in the mevalonate pathway for isoprenoid biosynthesis, is essential for growth of Listeria monocytogenes EGDe'
Heuston S, Begley M, Davey MS, Eberl M, Casey PG, Hill C, Gahan CG (2012) 'HmgR, a key enzyme in the mevalonate pathway for isoprenoid biosynthesis, is essential for growth of Listeria monocytogenes EGDe'. Microbiology (Reading, England), 158 (Pt 7):1684-1693 [DOI] [Details]
(2012)'Investigation of the role of ZurR in the physiology and pathogenesis of Listeria monocytogenes'
Dowd, GC,Casey, PG,Begley, M,Hill, C,Gahan, CGM (2012) 'Investigation of the role of ZurR in the physiology and pathogenesis of Listeria monocytogenes'. Fems Microbiology Letters, 327 :118-125 [DOI] [Details]
(2012)'A novel host-responsive sensor mediates virulence and type III secretion during Pseudomonas aeruginosa-host cell interactions'
O'Callaghan, J,Peen, FJ,Adams, C,Casey, PG,Gahan, CGM,O'Gara, F (2012) 'A novel host-responsive sensor mediates virulence and type III secretion during Pseudomonas aeruginosa-host cell interactions'. Microbiology-SGM, 158 :1057-1070 [DOI] [Details]
(2012)'A Putative P-Type ATPase Required for Virulence and Resistance to Haem Toxicity in Listeria monocytogenes'
McLaughlin, HP,Xiao, QB,Rea, RB,Pi, HL,Casey, PG,Darby, T,Charbit, A,Sleator, RD,Joyce, SA,Cowart, RE,Hill, C,Klebba, PE,Gahan, CGM (2012) 'A Putative P-Type ATPase Required for Virulence and Resistance to Haem Toxicity in Listeria monocytogenes'. Plos One, 7 [DOI] [Full Text] [Details]
(2012)'High Resolution In Vivo Bioluminescent Imaging For The Study Of Bacterial Tumour Targeting'
Cronin, M. C.,Akin, A. R.,Collins, S. A.,Meganck, J.,Kim, J-B.,Baban, C. K.,Joyce, S. A.,van Dam, G. M.,Zhang, N.,van Sinderen, D.,O'Sullivan, G. C.,Kasahara, N.,Gahan, C. G.,Francis, K. P.,Tangney, M. (2012) 'High Resolution In Vivo Bioluminescent Imaging For The Study Of Bacterial Tumour Targeting'. PLoS One, 7 (11) [Full Text] [Details]
(2011)'Investigation of the Mechanisms by Which Listeria monocytogenes Grows in Porcine Gallbladder Bile'
Dowd, G.C. and Joyce, S.A. and Hill, C. and Gahan, C.G.M. (2011) 'Investigation of the Mechanisms by Which Listeria monocytogenes Grows in Porcine Gallbladder Bile'. Infection and immunity, 79 (1) [Details]
(2011)'E. coli O104: H4: Social media and the characterisation of an emerging pathogen'
Casey, P.G. and Hill, C. and Gahan, CG (2011) 'E. coli O104: H4: Social media and the characterisation of an emerging pathogen'. Bioengineered bugs, 2 (4) [Details]
(2011)'The impact of iron on Listeria monocytogenes; inside and outside the host'
McLaughlin HP, Hill C, Gahan CG; (2011) 'The impact of iron on Listeria monocytogenes; inside and outside the host'. Current opinion in biotechnology, 22 (2):194-199 [DOI] [Details]
(2011)'Lactococcus lactis based vaccines: current status and future perspectives'
Bahey-el-din M and Gahan CG (2011) 'Lactococcus lactis based vaccines: current status and future perspectives'. Human Vaccines, 7 (1):106-109 [Details]
(2011)'Human neutrophil clearance of bacterial pathogens triggers anti-microbial $\gamma$$\delta$ T cell responses in early infection'
Davey, M.S. and Lin, C.Y. and Roberts, G.W. and Heuston, S. and Brown, A.C. and Chess, J.A. and Toleman, M.A. and Gahan, C.G.M. and Hill, C. and Parish, T. and others (2011) 'Human neutrophil clearance of bacterial pathogens triggers anti-microbial $\gamma$$\delta$ T cell responses in early infection'. Plos Pathogens, 7 (5) [Full Text] [Details]
(2011)'Factors affecting survival of Listeria monocytogenes and Listeria innocua in soil samples'
McLaughlin, H.P. and Casey, P.G. and Cotter, J. and Gahan, C.G.M. and Hill, C. (2011) 'Factors affecting survival of Listeria monocytogenes and Listeria innocua in soil samples'. Archives of Microbiology, :1-11 [Details]
(2010)'Lactococcus lactis as a cell factory for delivery of therapeutic proteins'
Bahey-El-Din, M; Gahan, CG; Griffin, BT; (2010) 'Lactococcus lactis as a cell factory for delivery of therapeutic proteins'. Current Gene Therapy, 10 (1):34-45 [Details]
(2010)'Bacterial vectors for gene and cell therapy'
Tangney T and Gahan CG (2010) 'Bacterial vectors for gene and cell therapy'. Current Gene Therapy, 10 (1):1-2 [Details]
(2010)'Lactococcus lactis: from the dairy industry to antigen and therapeutic protein delivery'
Bahey-el-Din, M an Gahan, CGM; (2010) 'Lactococcus lactis: from the dairy industry to antigen and therapeutic protein delivery'. Discovery medicine, 9 (48):455-461 Globe icon [Details]
(2010)'Molecular pathogenesis of Listeria monocytogenes in the alternative model host Galleria mellonella'
Joyce SA, Gahan CG; (2010) 'Molecular pathogenesis of Listeria monocytogenes in the alternative model host Galleria mellonella'. Microbiology, 156 (Pt 11):3456-3468 [DOI] [Details]
(2010)'Directed evolution and targeted mutagenesis to murinize listeria monocytogenes internalin A for enhanced infectivity in the murine oral infection model'
Monk, IR,Casey, PG,Hill, C,Gahan, CGM; (2010) 'Directed evolution and targeted mutagenesis to murinize listeria monocytogenes internalin A for enhanced infectivity in the murine oral infection model'. BMC Microbiology, 10 [DOI] [Details]
(2010)'Efficacy of a Lactococcus lactis ΔpyrG vaccine delivery platform expressing chromosomally integrated hly from Listeria monocytogenes'
Bahey-EL-Din, M; Caset, PG; Griffin, BT; Gahan, C; (2010) 'Efficacy of a Lactococcus lactis ΔpyrG vaccine delivery platform expressing chromosomally integrated hly from Listeria monocytogenes'. Bioengineered Bugs, 1 (1):66-74 Globe icon [Details]
(2010)'The truncated phage lysin CHAPk eliminates Staphylococcus aureus in the nares of mice'
Fenton M, Casey PG, Hill C, Gahan CG, Ross RP, McAuliffe O, O’Mahony J, Maher F, Coffey A (2010) 'The truncated phage lysin CHAPk eliminates Staphylococcus aureus in the nares of mice'. Bioengineered Bugs, 1 (6):1-4 [Details]
(2010)'The use of Listeria monocytogenes as a DNA delivery vector for cancer gene therapy'
Tangney M, van Pijkeren JP, Gahan CG; (2010) 'The use of Listeria monocytogenes as a DNA delivery vector for cancer gene therapy'. Bioengineered Bugs, 1 (4):284-287 [DOI] [Details]
(2010)'A novel Listeria monocytogenes-based DNA delivery system for cancer gene therapy'
van Pijkeren, JP; Morrissey, D; Monk, IR; Cronin, M; Rajendran, S; O'Sullivan, GC; Gahan, CG; Tangney, M; (2010) 'A novel Listeria monocytogenes-based DNA delivery system for cancer gene therapy'. Human Gene Therapy, 21 (4):405-416 [DOI] [Details]
(2010)'A five-gene stress survival islet (SSI-1) that contributes to the growth of Listeria monocytogenes in suboptimal conditions'
Ryan, S; Begley, M; Hill, C; Gahan, CG; (2010) 'A five-gene stress survival islet (SSI-1) that contributes to the growth of Listeria monocytogenes in suboptimal conditions'. Journal of Applied Microbiology, [DOI] [Details]
(2010)'Listeria monocytogenes as a vector for anti-cancer therapies'
Tangney, M; Gahan, CG; (2010) 'Listeria monocytogenes as a vector for anti-cancer therapies'. Current Gene Therapy, 10 (1):46-55 [Details]
(2010)'The use of Listeria monocytogenes as a DNA delivery vector for cancer gene therapy'
Tangney, M.,van Pijkeren, J. P.,Gahan, C. G.; (2010) 'The use of Listeria monocytogenes as a DNA delivery vector for cancer gene therapy'. Bioeng Bugs, 1 (44):284-7284 Globe icon [Details]
(2010)'Expression of two Listeria monocytogenes antigens (P60 and LLO) in Lactococcus lactis and examination for use as live vaccine vectors'
Bahey-EL-Din, M; Caset PG; Griffin, BT; Gahan, C; (2010) 'Expression of two Listeria monocytogenes antigens (P60 and LLO) in Lactococcus lactis and examination for use as live vaccine vectors'. Journal of Medical Microbiology, [DOI] [Details]
(2009)'Evaluation of colostrum-derived human mammary-associated serum amyloid A3 (M-SAA3) protein and peptide derivatives for the prevention of enteric infection: in vitro and in murine models of intestinal disease'
Gardiner, GE,O'Flaherty, S,Casey, PG,Weber, A,McDonald, TL,Cronin, M,Hill, C,Ross, RP,Gahan, CGM,Shanahan, F; (2009) 'Evaluation of colostrum-derived human mammary-associated serum amyloid A3 (M-SAA3) protein and peptide derivatives for the prevention of enteric infection: in vitro and in murine models of intestinal disease'. Fems Immunology and Medical Microbiology, 55 :404-413 [DOI] [Details]
(2009)'The interaction between Listeria monocytogenes and the host gastrointestinal tract'
Sleator RD, Watson D, Hill C, Gahan CG; (2009) 'The interaction between Listeria monocytogenes and the host gastrointestinal tract'. Microbiology, 155 (Pt 8):2463-2475 [DOI] [Details]
(2009)'Specific osmolyte transporters mediate bile tolerance in Listeria monocytogenes'
Watson, D; Sleator, RD; Casey, PG; Hill, C; Gahan, CG; (2009) 'Specific osmolyte transporters mediate bile tolerance in Listeria monocytogenes'. Infection and Immunity, 77 (11):4895-4904 [DOI] [Details]
(2009)'AgrD-dependent quorum sensing affects biofilm formation, invasion, virulence and global gene expression profiles in Listeria monocytogenes'
Riedel, CU,Monk, IR,Casey, PG,Waidmann, MS,Gahan, CGM,Hill, C; (2009) 'AgrD-dependent quorum sensing affects biofilm formation, invasion, virulence and global gene expression profiles in Listeria monocytogenes'. Molecular Microbiology, 71 :1177-1189 [DOI] [Details]
(2009)'Molecular characterization of the arginine deiminase system in Listeria monocytogenes: regulation and role in acid tolerance'
Ryan, S,Begley, M,Gahan, CGM,Hill, C; (2009) 'Molecular characterization of the arginine deiminase system in Listeria monocytogenes: regulation and role in acid tolerance'. Environmental Microbiology, 11 :432-445 [DOI] [Details]
(2008)'Tools for functional postgenomic analysis of Listeria monocytogenes'
Monk, IR,Gahan, CGM,Hill, C; (2008) 'Tools for functional postgenomic analysis of Listeria monocytogenes'. Applied and Environmental Microbiology, 74 :3921-3934 [DOI] [Details]
(2008)'Nisin inducible production of listeriolysin O in Lactococcus lactis NZ9000'
Bahey-El-Din M, Griffin BT, Gahan CG; (2008) 'Nisin inducible production of listeriolysin O in Lactococcus lactis NZ9000'. Microbial Cell Factories, 7 [DOI] [Full Text] [Details]
(2008)'Pseudomonas aeruginosa RsmA plays an important role during murine infection by influencing colonization, virulence, persistence, and pulmonary inflammation'
Mulcahy H, O'Callaghan J, O'Grady EP, Maciá MD, Borrell N, Gómez C, Casey PG, Hill C, Adams C, Gahan CG, Oliver A, O'Gara F; (2008) 'Pseudomonas aeruginosa RsmA plays an important role during murine infection by influencing colonization, virulence, persistence, and pulmonary inflammation'. Infection and Immunity, 76 (2):632-638 [DOI] [Details]
(2008)'Development of Multiple Strain Competitive Index Assays For Listeria Monocytogenes Using Pimc; A New Site-Specific Integrative Vector'
Monk, IR, Casey, PG, Cronin, M, Gahan, CG, Hill, C; (2008) 'Development of Multiple Strain Competitive Index Assays For Listeria Monocytogenes Using Pimc; A New Site-Specific Integrative Vector'. BMC Microbiology, 8 (NA) [DOI] [Details]
(2008)'Functional and comparative metagenomic analysis of bile salt hydrolase activity in the human gut microbiome'
Jones BV, Begley M, Hill C, Gahan CG, Marchesi JR; (2008) 'Functional and comparative metagenomic analysis of bile salt hydrolase activity in the human gut microbiome'. Proceedings of The National Academy of Sciences of The United States of America, 105 (36):13580-13585 [DOI] [Details]
(2008)'M-cells: origin, morphology and role in mucosal immunity and microbial pathogenesis'
Corr SC, Gahan CC, Hill C; (2008) 'M-cells: origin, morphology and role in mucosal immunity and microbial pathogenesis'. Fems Immunology and Medical Microbiology, 52 (1):2-12 [DOI] [Details]
(2008)'Acid stress responses in Listeria monocytogenes'
Ryan S, Hill C, Gahan CG; (2008) 'Acid stress responses in Listeria monocytogenes'. Advances In Applied Microbiology, 65 :67-91 [DOI] [Details]
(2008)'Analysis of The Isoprenoid Biosynthesis Pathways In Listeria Monocytogenes Reveals A Role For The Alternative 2-C-Methyl-D-Erythritol 4-Phosphate Pathway In Murine Infection'
Begley, M, Bron, PA, Heuston, S, Casey, PG, Englert, N, Wiesner, J, Jomaa, H, Gahan, CGM, Hill, C; (2008) 'Analysis of The Isoprenoid Biosynthesis Pathways In Listeria Monocytogenes Reveals A Role For The Alternative 2-C-Methyl-D-Erythritol 4-Phosphate Pathway In Murine Infection'. Infection and Immunity, 76 (11):5392-5401 [DOI] [Details]
(2008)'A Significant Role For Sigma B In The Detergent Stress Response of Listeria Monocytogenes'
Ryan, EM, Gahan, CGM, Hill, C; (2008) 'A Significant Role For Sigma B In The Detergent Stress Response of Listeria Monocytogenes'. Letters In Applied Microbiology, 46 (2):148-154 [DOI] [Details]
(2008)'Tools For Functional Postgenomic Analysis of Listeria Monocytogenes'
Monk, IR, Gahan, CGM, Hill, C; (2008) 'Tools For Functional Postgenomic Analysis of Listeria Monocytogenes'. Applied and Environmental Microbiology, 74 (13):3921-3934 [DOI] [Details]
(2008)'Enhancing Bile Tolerance Improves Survival and Persistence of Bifidobacterium and Lactococcus In The Murine Gastrointestinal Tract'
Watson, D, Sleator, RD, Hill, C, Gahan, CGM; (2008) 'Enhancing Bile Tolerance Improves Survival and Persistence of Bifidobacterium and Lactococcus In The Murine Gastrointestinal Tract'. BMC Microbiology, 8 (NA) [DOI] [Details]
(2008)'Lactococcus lactis-expressing listeriolysin O (LLO) provides protection and specific CD8(+) T cells against Listeria monocytogenes in the murine infection model'
Bahey-El-Din, M,Casey, PG,Griffin, BT,Gahan, CGM; (2008) 'Lactococcus lactis-expressing listeriolysin O (LLO) provides protection and specific CD8(+) T cells against Listeria monocytogenes in the murine infection model'. Vaccine, 26 :5304-5314 [DOI] [Details]
(2008)'Analysis of the Isoprenoid Biosynthesis Pathways in Listeria monocytogenes Reveals a Role for the Alternative 2-C-Methyl-D-Erythritol 4-Phosphate Pathway in Murine Infection'
Begley, M,Bron, PA,Heuston, S,Casey, PG,Englert, N,Wiesner, J,Jomaa, H,Gahan, CGM,Hill, C; (2008) 'Analysis of the Isoprenoid Biosynthesis Pathways in Listeria monocytogenes Reveals a Role for the Alternative 2-C-Methyl-D-Erythritol 4-Phosphate Pathway in Murine Infection'. Infection and Immunity, 76 :5392-5401 [DOI] [Details]
(2007)'A novel promoter trap identifies Listeria monocytogenes promoters expressed at a low pH within the macrophage phagosome'
Stack HM, Gahan CG, Hill C; (2007) 'A novel promoter trap identifies Listeria monocytogenes promoters expressed at a low pH within the macrophage phagosome'. Fems Microbiology Letters, 274 (1):139-147 [DOI] [Details]
(2007)'The Glutamate Decarboxylase Acid Resistance Mechanism Affects Survival of Listeria Monocytogenes Lo28 In Modified Atmosphere-Packaged Foods'
Francis, GA, Scollard, J, Meally, A, Bolton, DJ, Gahan, CGM, Cotter, PD, Hill, C, O'Beirne, D; (2007) 'The Glutamate Decarboxylase Acid Resistance Mechanism Affects Survival of Listeria Monocytogenes Lo28 In Modified Atmosphere-Packaged Foods'. Journal of Applied Microbiology, 103 (6):2316-2324 [DOI] [Details]
(2007)'Construction of p16Slux, a Novel Vector for Improved Bioluminescent Labelling of Gram-Negative Bacteria'
Riedel CU, Casey PG, Mulcahy H, O'Gara F, Gahan CGM and Hill C.; (2007) 'Construction of p16Slux, a Novel Vector for Improved Bioluminescent Labelling of Gram-Negative Bacteria'. Applied Environmental Microbiology, 73 (21):7092-7095 [Details]
(2007)'An improved luciferase tagging system for Listeria monocytogenes allows real-time monitoring in vivo and in vitro'
Riedel CU, Monk IR, Casey PG, Morrissey D, O'Sullivan GC, Tangney M, Hill C and Gahan CGM.; (2007) 'An improved luciferase tagging system for Listeria monocytogenes allows real-time monitoring in vivo and in vitro'. Applied and Environmental Microbiology, 73 (9):3091-3094 [Details]
(2007)'(From the cover) Bacteriocin production as a mechanism for the anti-infective activity of Lactobacillus salivarius UCC118'
Corr SC, Li Y, Riedel CU, O’Toole PW, Hill C and Gahan CGM; (2007) '(From the cover) Bacteriocin production as a mechanism for the anti-infective activity of Lactobacillus salivarius UCC118'. Proceedings of The National Acadamy of Sciences, 104 (18):7617-7621 [Details]
(2007)'Improved luciferase tagging system for Listeria monocytogenes allows real-time monitoring in vivo and in vitro'
Riedel, CU,Monk, IR,Casey, PG,Morrissey, D,O'Sullivan, GC,Tangney, M,Hill, C,Gahan, CGM; (2007) 'Improved luciferase tagging system for Listeria monocytogenes allows real-time monitoring in vivo and in vitro'. Applied and Environmental Microbiology, 73 :3091-3094 [DOI] [Details]
(2007)'Impact of selected Lactobacillus and Bifidobacterium species on Listeria monocytogenes infection and the mucosal immune response'
Corr, SC,Gahan, CGM,Hill, C; (2007) 'Impact of selected Lactobacillus and Bifidobacterium species on Listeria monocytogenes infection and the mucosal immune response'. Fems Immunology and Medical Microbiology, 50 :380-388 [DOI] [Details]
(2006)'Novel luciferase reporter system for in vitro and organ-specific monitoring of differential gene expression in Listetia monocytogenes'
Bron, PA,Monk, IR,Corr, SC,Hill, C,Gahan, CGM; (2006) 'Novel luciferase reporter system for in vitro and organ-specific monitoring of differential gene expression in Listetia monocytogenes'. Applied and Environmental Microbiology, 72 :2876-2884 [DOI] [Details]
(2006)'A novel luciferase reporter system for monitoring in vitro and organ-specific differential gene expression in Listeria monocytogenes'
Bron PA, IR Monk, SC Corr, C Hill and CGM Gahan.; (2006) 'A novel luciferase reporter system for monitoring in vitro and organ-specific differential gene expression in Listeria monocytogenes'. Applied and Environmental Microbiology, 72 (4):2876-2884 [Details]
(2006)'An in vitro cell-culture model demonstrates internalin- and hemolysin-independent translocation of Listeria monocytogenes across M cells'
Corr S, Hill C, Gahan CG; (2006) 'An in vitro cell-culture model demonstrates internalin- and hemolysin-independent translocation of Listeria monocytogenes across M cells'. Microbial Pathogenesis, 41 (6):241-250 [DOI] [Details]
(2006)'Bile salt hydrolase activity in probiotics'
Begley M, Hill C, Gahan CG; (2006) 'Bile salt hydrolase activity in probiotics'. Applied and Environmental Microbiology, 72 (3):1729-1738 [DOI] [Details]
(2005)'A PrfA-regulated bile exclusion system (BilE) is a novel virulence factor in Listeria monocytogenes'
Sleator RD, Wemekamp-Kamphuis HH, Gahan CG, Abee T, Hill C.; (2005) 'A PrfA-regulated bile exclusion system (BilE) is a novel virulence factor in Listeria monocytogenes'. Molecular Microbiology, 55 (4):1183-1195 [Details]
(2005)'Contribution of three bile-associated loci, bsh, pva, and btlB, to gastrointestinal persistence and bile tolerance of Listeria monocytogenes. '
Begley M, Sleator RD, Gahan* CG, Hill C.; (2005) 'Contribution of three bile-associated loci, bsh, pva, and btlB, to gastrointestinal persistence and bile tolerance of Listeria monocytogenes. '. Infection and Immunity, 73 (2):894-904 [Details]
(2005)'Listeria monocytogenes PerR mutants display a small-colony phenotype, increased sensitivity to hydrogen peroxide, and significantly reduced murine virulence'
Rea R, Hill C, Gahan CG; (2005) 'Listeria monocytogenes PerR mutants display a small-colony phenotype, increased sensitivity to hydrogen peroxide, and significantly reduced murine virulence'. Applied and Environmental Microbiology, 71 (12):8314-8322 [DOI] [Details]
(2005)'The interaction between bacteria and bile'
Begley M, Gahan CG, Hill C; (2005) 'The interaction between bacteria and bile'. Fems Microbiology Reviews, 29 (4):625-651 [DOI] [Details]
(2005)'Role for HtrA in stress induction and virulence potential in Listeria monocytogenes'
Stack HM, Sleator RD, Bowers M, Hill C, Gahan CG; (2005) 'Role for HtrA in stress induction and virulence potential in Listeria monocytogenes'. Applied and Environmental Microbiology, 71 (8):4241-4247 [DOI] [Details]
(2005)'Presence of GadD1 glutamate decarboxylase in selected Listeria monocytogenes strains is associated with an ability to grow at low pH'
Cotter PD, Ryan S, Gahan CG, Hill C; (2005) 'Presence of GadD1 glutamate decarboxylase in selected Listeria monocytogenes strains is associated with an ability to grow at low pH'. Applied and Environmental Microbiology, 71 (6):2832-2839 [DOI] [Details]
(2005)'Gastrointestinal phase of Listeria monocytogenes infection'
Gahan CG, Hill C; (2005) 'Gastrointestinal phase of Listeria monocytogenes infection'. Journal of Applied Microbiology, 98 (6):1345-1353 [DOI] [Details]
(2005)'Role for HtrA in stress induction and virulence potential in Listeria monocytogenes'
Stack, HM,Sleator, RD,Bowers, M,Hill, C,Gahan, CGM; (2005) 'Role for HtrA in stress induction and virulence potential in Listeria monocytogenes'. Applied and Environmental Microbiology, 71 :4241-4247 [DOI] [Details]
(2005)'The Dps-like protein Fri of Listeria monocytogenes promotes stress tolerance and intracellular multiplication in macrophage-like cells'
Olsen, KN,Larsen, MH,Gahan, CGM,Kallipolitis, B,Wolf, XA,Rea, R,Hill, C,Ingmer, H; (2005) 'The Dps-like protein Fri of Listeria monocytogenes promotes stress tolerance and intracellular multiplication in macrophage-like cells'. Microbiology-SGM, 151 :925-933 [DOI] [Details]
(2005)'Listeria monocytogenes PerR mutants display a small-colony phenotype, increased sensitivity to hydrogen peroxide, and significantly reduced murine virulence'
Rea, R,Hill, C,Gahan, CGM; (2005) 'Listeria monocytogenes PerR mutants display a small-colony phenotype, increased sensitivity to hydrogen peroxide, and significantly reduced murine virulence'. Applied and Environmental Microbiology, 71 :8314-8322 [DOI] [Details]
(2005)'Presence of GadD1 glutamate decarboxylase in selected Listeria monocytogenes strains is associated with an ability to grow at low pH'
Cotter, PD,Ryan, S,Gahan, CGM,Hill, C; (2005) 'Presence of GadD1 glutamate decarboxylase in selected Listeria monocytogenes strains is associated with an ability to grow at low pH'. Applied and Environmental Microbiology, 71 :2832-2839 [DOI] [Details]
(2004)'Disruption of putative regulatory loci in Listeria monocytogenes demonstrates a significant role for fur and PerR in virulence'
Rea, RB,Gahan, CGM,Hill, C; (2004) 'Disruption of putative regulatory loci in Listeria monocytogenes demonstrates a significant role for fur and PerR in virulence'. Infection and Immunity, 72 :717-727 [DOI] [Details]
(2004)'The interplay between classical and alternative isoprenoid biosynthesis controls gammadelta T cell bioactivity of Listeria monocytogenes'
Begley M, Gahan CG, Kollas AK, Hintz M, Hill C, Jomaa H, Eberl M; (2004) 'The interplay between classical and alternative isoprenoid biosynthesis controls gammadelta T cell bioactivity of Listeria monocytogenes'. Febs Letters, 561 (1-3):99-104 [DOI] [Details]
(2003)'CesRK, a two-component signal transduction system in Listeria monocytogenes, responds to the presence of cell wall-acting antibiotics and affects beta-lactam resistance'
Kallipolitis, BH,Ingmer, H,Gahan, CG,Hill, C,Sogaard-Andersen, L; (2003) 'CesRK, a two-component signal transduction system in Listeria monocytogenes, responds to the presence of cell wall-acting antibiotics and affects beta-lactam resistance'. Antimicrobial Agents and Chemotherapy, 47 :3421-3429 [DOI] [Details]
(2003)'Identification and disruption of bt1A a locus involved in bile tolerance and general stress resistance in listeia monocytogenes'
Begley, M., Gahan, C., Hill, C.; (2003) 'Identification and disruption of bt1A a locus involved in bile tolerance and general stress resistance in listeia monocytogenes'. Fems Microbiology Letters, 218 (*):31-38 [Details]
(2003)'A single amino acid deletion in the glycine rich region of CtsrR affects motilit, piezotolerance and virulence of listeria monocytogenes'
Karatzas, KAD, Wouters, C., Gahan, C., Hill, C., Abee, T., Bennik, MHJ.; (2003) 'A single amino acid deletion in the glycine rich region of CtsrR affects motilit, piezotolerance and virulence of listeria monocytogenes'. Molecular Microbiology, 49 (*):1227-1238 [Details]
(2003)'Bacterial stress response in listeria monocytogenes: jumping the hurdles inposed by minimal processing'
Hill, C., Cotter, PD., Sleator, RD., Gahan, C.; (2003) 'Bacterial stress response in listeria monocytogenes: jumping the hurdles inposed by minimal processing'. International Dairy Journal, 12 (*):273-283 [Details]
(2003)'A postgenomic appraisal of osmotolerance in listeria monocytogenes'
Sleator, RD., Gahan, C., Hill, C.; (2003) 'A postgenomic appraisal of osmotolerance in listeria monocytogenes'. Applied and Environmental Microbiology, 69 (1):1-9 [Details]
(2003)'Analysis of the contribution of betaine and carnitine uptake systems to the growth and survival of listeria monocytogenes in foods and during infection'
Sleator, RD., Francis, GA., O'Beirne, DD., Gahan*, C., Hill,C.; (2003) 'Analysis of the contribution of betaine and carnitine uptake systems to the growth and survival of listeria monocytogenes in foods and during infection'. Journal of Applied Microbiology, 95 (4):839-846 [Details]
(2003)'a two component signal transduction system in listeria monocytogenes responds to the presence of cell wall acting antobiotics and affects betalactam resistance'
Kallipolitis, BH., Ingmer, H., Gahan, C., Hill, C., Sogaard-Andersen, L.; (2003) 'a two component signal transduction system in listeria monocytogenes responds to the presence of cell wall acting antobiotics and affects betalactam resistance'. Antimicrobial Agents and Chemotherapy, 47 (11):3421-3429 [Details]
(2003)'Betaine and carnitine uptake systems in listeria monocytogenes affect growth and survival in foods and during infection'
Sleator, R., Francis, G., O'Beirne, D, Gahan, C.G.M, and Hill, C.; (2003) 'Betaine and carnitine uptake systems in listeria monocytogenes affect growth and survival in foods and during infection'. Journal of Applied Microbiology, 95 (*):829-845 [Details]
(2003)'A postgenomic appraisal of osmotolerance in Listeria monocytogenes'
Sleator RD, Gahan CG, Hill C; (2003) 'A postgenomic appraisal of osmotolerance in Listeria monocytogenes'. Applied and Environmental Microbiology, 69 (1):1-9 [Details]
(2003)'CesRK, a two-component system in listeria monocytogenes responds to the presence of cell wall antibiotics and affects lactam resistance'
Kallipollitis, B., Ingmer, H., Gahan, C., Hill,C., Sogaard-Anderson, L.; (2003) 'CesRK, a two-component system in listeria monocytogenes responds to the presence of cell wall antibiotics and affects lactam resistance'. Molecular Microbiology, 47 (*):3241-3249 [Details]
(2003)'A postgenomic appraisal of osmotolerance in Listeria monocytogenes'
Sleator, RD and Gahan, CGM and Hill, C; (2003) 'A postgenomic appraisal of osmotolerance in Listeria monocytogenes'. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 69 (1):1-9 [DOI] [Details]
(2003)'Identification and disruption of btlA, a locus involved in bile tolerance and general stress resistance in Listeria monocytogenes'
Begley, M,Hill, C,Gahan, CGM; (2003) 'Identification and disruption of btlA, a locus involved in bile tolerance and general stress resistance in Listeria monocytogenes'. Fems Microbiology Letters, 218 :31-38 [DOI] [Details]
(2003)'Betaine and carnitine uptake systems in Listeria monocytogenes affect growth and survival in foods and during infection'
Sleator, RD,Francis, GA,O'Beirne, D,Gahan, CGM,Hill, C; (2003) 'Betaine and carnitine uptake systems in Listeria monocytogenes affect growth and survival in foods and during infection'. Journal of Applied Microbiology, 95 :839-846 [Details]
(2003)'The CtsR regulator of Listeria monocytogenes contains a variant glycine repeat region that affects piezotolerance, stress resistance, motility and virulence'
Karatzas, KAG,Wouters, JA,Gahan, CGM,Hill, C,Abee, T,Bennik, MHJ; (2003) 'The CtsR regulator of Listeria monocytogenes contains a variant glycine repeat region that affects piezotolerance, stress resistance, motility and virulence'. Molecular Microbiology, 49 :1227-1238 [DOI] [Details]
(2002)'Multiple deletions of the osmolyte transporters BetL, Gbu, and OpuC of Listeria monocytogenes affect virulence and growth at high osmolarity'
Wemekamp-Kamphuis, HH,Wouters, JA,Sleator, RD,Gahan, CGM,Hill, C,Abee, T; (2002) 'Multiple deletions of the osmolyte transporters BetL, Gbu, and OpuC of Listeria monocytogenes affect virulence and growth at high osmolarity'. Applied and Environmental Microbiology, 68 :4710-4716 [DOI] [Details]
(2002)'Bacterial stress response in Listeria monocytogenes: jumping the hurdles imposed by minimal processing'
Hill C, Cotter PD, Sleator RD and Gahan CG; (2002) 'Bacterial stress response in Listeria monocytogenes: jumping the hurdles imposed by minimal processing'. International Dairy Journal, 12 :273-283 [Details]
(2002)'Bile stress response in Listeria monocytogenes LO28: adaptation, cross-protection, and identification of genetic loci involved in bile resistance'
Begley M, Gahan CG, Hill C; (2002) 'Bile stress response in Listeria monocytogenes LO28: adaptation, cross-protection, and identification of genetic loci involved in bile resistance'. Applied and Environmental Microbiology, 68 (12):6005-6012 [Details]
(2002)'Bacterial stress response in Listeria monocytogenes: jumping the hurdles imposed by minimal processing'
Hill, C and Cotter, PD and Sleator, RD and Gahan, CGM; (2002) 'Bacterial stress response in Listeria monocytogenes: jumping the hurdles imposed by minimal processing'. INTERNATIONAL DAIRY JOURNAL, 12 (2-3, Sp. Iss. SI):273-283 [Details]
(2001)'Characterization of the groESL operon in Listeria monocytogenes: Utilization of two reporter systems (gfp and hly) for evaluating in vivo expression'
Gahan, CGM,O'Mahony, J,Hill, C; (2001) 'Characterization of the groESL operon in Listeria monocytogenes: Utilization of two reporter systems (gfp and hly) for evaluating in vivo expression'. Infection and Immunity, 69 :3924-3932 [Details]
(2001)'A glutamate decarboxylase system protects Listeria monocytogenes in gastric fluid'
Cotter, PD,Gahan, CGM,Hill, C; (2001) 'A glutamate decarboxylase system protects Listeria monocytogenes in gastric fluid'. Molecular Microbiology, 40 :465-475 [Details]
(2001)'Mutations in the listerial proB gene leading to proline overproduction: Effects on salt tolerance and murine infection'
Sleator, RD,Gahan, CGM,Hill, C; (2001) 'Mutations in the listerial proB gene leading to proline overproduction: Effects on salt tolerance and murine infection'. Applied and Environmental Microbiology, 67 :4560-4565 [Details]
(2001)'Analysis of the role of OpuC, an osmolyte transport system, in salt tolerance and virulence potential of Listeria monocytogenes. '
Sleator RD, Wouters J, Gahan CG, Abee T, Hill C.; (2001) 'Analysis of the role of OpuC, an osmolyte transport system, in salt tolerance and virulence potential of Listeria monocytogenes. '. Applied Environmental Microbiology, 67 (6):2692-2698 [Details]
(2001)'Identification and disruption of the proBA locus in Listeria monocytogenes: role of proline biosynthesis in salt tolerance and murine infection'
Sleator RD, Gahan CG, Hill C; (2001) 'Identification and disruption of the proBA locus in Listeria monocytogenes: role of proline biosynthesis in salt tolerance and murine infection'. Applied and Environmental Microbiology, 67 (6):2571-2577 [DOI] [Details]
(2001)'Analysis of the role of OpuC, an osmolyte transport system, in salt tolerance and virulence potential of Listeria monocytogenes'
Sleator, RD,Wouters, J,Gahan, CGM,Abee, T,Hill, C; (2001) 'Analysis of the role of OpuC, an osmolyte transport system, in salt tolerance and virulence potential of Listeria monocytogenes'. Applied and Environmental Microbiology, 67 :2692-2698 [Details]
(2001)'Identification and disruption of the proBA locus in Listeria monocytogenes: Role of proline biosynthesis in salt tolerance and murine infection'
Sleator, RD,Gahan, CGM,Hill, C; (2001) 'Identification and disruption of the proBA locus in Listeria monocytogenes: Role of proline biosynthesis in salt tolerance and murine infection'. Applied and Environmental Microbiology, 67 :2571-2577 [Details]
(2000)'The use of listeriolysin to identify in vivo induced genes in the gram-positive intracellular pathogen Listeria monocytogenes'
Gahan CG, Hill C.; (2000) 'The use of listeriolysin to identify in vivo induced genes in the gram-positive intracellular pathogen Listeria monocytogenes'. Molecular Microbiology, 36 (2):498-507 [Details]
(2000)'Analysis of the role of the Listeria monocytogenes F0F1 -AtPase operon in the acid tolerance response. '
Cotter PD, Gahan CG, Hill C.; (2000) 'Analysis of the role of the Listeria monocytogenes F0F1 -AtPase operon in the acid tolerance response. '. International Journal of Food Microbiology, 60 (2-3):137-146 [Details]
(2000)'Analysis of the role of betL in contributing to the growth and survival of Listeria monocytogenes LO28. '
Sleator RD, Gahan CGM, O'Driscoll B, Hill C.; (2000) 'Analysis of the role of betL in contributing to the growth and survival of Listeria monocytogenes LO28. '. International Journal of Food Microbiology, 60 (2-3):261-268 [Details]
(2000)'Listeria monocytogenes: role of stress in virulence and survival in food'
Hill, C and C. Gahan.; (2000) 'Listeria monocytogenes: role of stress in virulence and survival in food'. Irish Journal of Agricultural Food Research, 39 (*):195-202 [Details]
(2000)'Analysis of the role of the Listeria monocytogenes F0F1-ATPase operon in the acid tolerance response'
Cotter, PD and Gahan, CGM and Hill, C; (2000) 'Analysis of the role of the Listeria monocytogenes F0F1-ATPase operon in the acid tolerance response'. INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY, 60 (2-3, Sp. Iss. SI):137-146 [Details]
(2000)'The use of listeriolysin to identify in vivo induced genes in the gram-positive intracellular pathogen Listeria monocytogenes'
Gahan CG, Hill C; (2000) 'The use of listeriolysin to identify in vivo induced genes in the gram-positive intracellular pathogen Listeria monocytogenes'. Molecular Microbiology, 36 (2):498-507 [Details]
(1999)'Identification and disruption of BetL, a secondary glycine betaine transport system linked to the salt tolerance of Listeria monocytogenes LO28'
Sleator RD, Gahan CG, Abee T, Hill C; (1999) 'Identification and disruption of BetL, a secondary glycine betaine transport system linked to the salt tolerance of Listeria monocytogenes LO28'. Applied and Environmental Microbiology, 65 (5):2078-2083 [Details]
(1999)'The relationship between acid stress responses and virulence in Salmonella typhimurium and Listeria monocytogenes'
Gahan CG, Hill C; (1999) 'The relationship between acid stress responses and virulence in Salmonella typhimurium and Listeria monocytogenes'. International Journal of Food Microbiology, 50 (1-2):93-100 [Details]
(1999)'Identification and disruption of lisRK, a genetic locus encoding a two-component signal transduction system involved in stress tolerance and virulence in Listeria monocytogenes'
Cotter PD, Emerson N, Gahan CG, Hill C; (1999) 'Identification and disruption of lisRK, a genetic locus encoding a two-component signal transduction system involved in stress tolerance and virulence in Listeria monocytogenes'. Journal of Bacteriology, 181 (21):6840-6843 [Details]
(1999)'The relationship between acid stress responses and virulence in Salmonella typhimurium and Listeria monocytogenes'
Gahan, CGM and Hill, C; (1999) 'The relationship between acid stress responses and virulence in Salmonella typhimurium and Listeria monocytogenes'. INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY, 50 (1-2):93-100 [Details]
(1999)'Identification and disruption of lisRK, a genetic locus encoding a two-component signal transduction system involved in stress tolerance and virulence in Listeria monocytogenes. '
Cotter PD, Emerson N, Gahan CG, Hill C.; (1999) 'Identification and disruption of lisRK, a genetic locus encoding a two-component signal transduction system involved in stress tolerance and virulence in Listeria monocytogenes. '. Journal of Bacteriology, 181 (21):6840-6843 [Details]
(1999)'Identification and disruption of BetL, a secondary glycine betaine transport system linked to the salt tolerance of Listeria monocytogenes LO28. '
Sleator RD, Gahan CG, Abee T, Hill C.; (1999) 'Identification and disruption of BetL, a secondary glycine betaine transport system linked to the salt tolerance of Listeria monocytogenes LO28. '. Applied Environmental Microbiology, 65 (5):2078-2083 [Details]
(1999)'Acid-adapted Listeria monocytogenes displays enhanced tolerance against the lantibiotics nisin and lacticin 3147'
van Schaik, W,Gahan, CGM,Hill, C; (1999) 'Acid-adapted Listeria monocytogenes displays enhanced tolerance against the lantibiotics nisin and lacticin 3147'. Journal of Food Protection, 62 :536-539 [Details]
(1999)'Identification and disruption of BetL, a secondary glycine betaine transporter important in salt tolerance of Listeria monocytogenes LO28'
Sleator, R., Gahan, C. Abee, T. and Hill, C.; (1999) 'Identification and disruption of BetL, a secondary glycine betaine transporter important in salt tolerance of Listeria monocytogenes LO28'. Applied Environmental Microbiology, 65 (*):2078-2083 [Details]
(1997)'A mutant of Listeria monocytogenes LO28 unable to induce an acid tolerance response displays diminished virulence in a murine model. '
Marron L, Emerson N, Gahan CG, Hill C.; (1997) 'A mutant of Listeria monocytogenes LO28 unable to induce an acid tolerance response displays diminished virulence in a murine model. '. Applied and Environmental Microbiology, 63 (12):4945-4947 [Details]
(1997)'Innate Resistance to Listeria Monocytogenes in Tumor-Bearing Mice [B2319]'
Gahan, C.; Barrett, M.; O'Brien, M.; O'Sullivan, G.; Shanahan, F.; Collins, J. K.; (1997) 'Innate Resistance to Listeria Monocytogenes in Tumor-Bearing Mice [B2319]'. Journal of Leukocyte Biology, 62 :726-732 [Details]
(1997)'Two Dimensional protein analysis of the acid tolerance response in Listeria monocytogenes L028'
O'Driscoll, B.; Gahan, C.; Hill, Colin; (1997) 'Two Dimensional protein analysis of the acid tolerance response in Listeria monocytogenes L028'. Applied and Environmental Microbiology, 63 (*):2679-2685 [Details]
(1996)'Adaptive acid tolerance response in Listeria monocytogenes: isolation of an acid-tolerant mutant which demonstrates increased virulence. '
O'Driscoll B, Gahan CG, Hill C.; (1996) 'Adaptive acid tolerance response in Listeria monocytogenes: isolation of an acid-tolerant mutant which demonstrates increased virulence. '. Applied Environmental Microbiology, 62 (5):1693-1698 [Details]
(1996)'Acid Adaptation of Listeria Monocytogenes Can Enhance Survival in Acidic Foods and During Milk Fermentation [B2351]'
Gahan, C.; O'Driscoll, B.; Hill, Colin; (1996) 'Acid Adaptation of Listeria Monocytogenes Can Enhance Survival in Acidic Foods and During Milk Fermentation [B2351]'. Applied and Environmental Microbiology, 62 (*):3128-2132 [Details]
(1996)'Adaptive Acid Tolerance Response in {Listeria Monocytogenes}: Isolation of an Acid-Tolerant Mutant Which Demonstrates Increased Virulence [B2350]'
O'Driscoll, B.; Gahan, C.; Hill, Colin; (1996) 'Adaptive Acid Tolerance Response in {Listeria Monocytogenes}: Isolation of an Acid-Tolerant Mutant Which Demonstrates Increased Virulence [B2350]'. Applied and Environmental Microbiology, :1693-1698 [Details]
(1995)'Vaccination of mice with attenuated mutants of Listeria monocytogenes : requirement for induction of macrophage Ia expression'
Gahan CG and JK Collins; (1995) 'Vaccination of mice with attenuated mutants of Listeria monocytogenes : requirement for induction of macrophage Ia expression'. Microbial Pathogenesis, 18 :417-422 [Details]
(1995)'Non-dystrophic 129 REJ mice are susceptible to i.p. infection with Listeria monocytogenes despite an ability to recruit inflammatory neutrophils to the peritoneal cavity'
Gahan CG and JK Collins; (1995) 'Non-dystrophic 129 REJ mice are susceptible to i.p. infection with Listeria monocytogenes despite an ability to recruit inflammatory neutrophils to the peritoneal cavity'. Microbial Pathogenesis, 18 :355-364 [Details]
(1991)'Listeriosis: Biology and implications for the food industry'
Gahan CG and JK Collins; (1991) 'Listeriosis: Biology and implications for the food industry'. Trends in Food Science & Technology, 2 :89-93 [Details]
(0)'Innate Resistance to {Listeria Monocytogenes} in Tumor-Bearing Mice [B1646]'
Gahan, C. G.; Barrett, J. R.; O'Brien, M. G.; O'Sullivan, G. C.; Shanahan, F.; Collins, J. K.; (0) 'Innate Resistance to {Listeria Monocytogenes} in Tumor-Bearing Mice [B1646]'. Journal of Leukocyte Biology, 62 :726-732 [Details]

Book Chapters

 YearPublication
(2010)'Responses of Listeria monocytogenes to different stresses'
Dowd G, Hill C and CGM Gahan; (2010) 'Responses of Listeria monocytogenes to different stresses' In: Stress responses in foodborne pathogens. New York: Nova Science Publishers. [Details]
(2008)'Listeria monocytogenes: stress responses'
Stack, HM, Hill C, CGM Gahan; (2008) 'Listeria monocytogenes: stress responses' In: Handbook of Listeria monocytogenes. Cambridge: CRC Press. [Details]
(2008)'Attack and counter-attack: targeted immunomodulation using bacterial virulence factors'
Bahey-El-Din M, Griffin BT and CGM Gahan; (2008) 'Attack and counter-attack: targeted immunomodulation using bacterial virulence factors' In: Patho-Biotechnology. Austin: Landes BioSciences. [Details]
(2006)'Specific immune mechanisms of defence against foodborne pathogens'
Gahan CG; (2006) 'Specific immune mechanisms of defence against foodborne pathogens' In: Food consumption and disease risk. Cambridge: CRC Press. [Details]
(2003)'Microbial adaptation to stress and safety of new generation foods¿. (Yousef, A. E. and V. Juneja; Eds.)'
Gahan, C., and C. Hill. ; (2003) 'Microbial adaptation to stress and safety of new generation foods¿. (Yousef, A. E. and V. Juneja; Eds.)' In: Relationship of stress adaptation and virulence in foodborne pathogenic bacteria. CRC Press, Florida, USA: CRC Press. [Details]
(2003)'Relationship between stress adaptation and virulence in foodborne pathogenic bacteria'
Gahan CG and C Hill; (2003) 'Relationship between stress adaptation and virulence in foodborne pathogenic bacteria' In: Microbial Stress Adaptation and Food Safety. [Details]

Abstract

 YearPublication
(2010)Innate crosstalk of gamma delta T cells, neutrophils and monocytes in response to HMB-PP producing bacteria.
Davey, MS,Heuston, S,Brown, AC,Walsh, TR,Toleman, MA,Gahan, CGM,Hill, C,Parish, T,Moser, B,Eberl, M (2010) Innate crosstalk of gamma delta T cells, neutrophils and monocytes in response to HMB-PP producing bacteria. Abstract [Details]
(2010)Non-pathogenic bacteria as cell therapy vectors for cancer treatment.
Cronin, M,Collins, S,Inagaki, A,Hiraoka, K,Kasahara, N,Gahan, CGM,O'Sullivan, GC,Tangney, M (2010) Non-pathogenic bacteria as cell therapy vectors for cancer treatment. Abstract [Details]
(2007)Role of agrD for biofim formation and virulence in L. monocytogenes.
Riedel, CU,Monk, IR,Casey, P,Gahan, CGM,Hill, C (2007) Role of agrD for biofim formation and virulence in L. monocytogenes. Abstract [Details]

Professional Associations

 AssociationFunctionFrom / To
Society for General Microbiology Member/
American Society for Microbiology Member/

Conference Contributions

 YearPublication
(2009)Society for General Microbiology,
Cormac GM Gahan; (2009) Beginning to see the light: Listeria pathogenesis and real-time imaging in the mouse. [Invited Oral Presentation], Society for General Microbiology, University College Cork , 23-APR-09 - 24-APR-09. [Details]
(2009)Society for General Microbiology,
Cormac GM Gahan; (2009) Real-time non-invasive monitoring of bacterial infections in vivo. [Invited Oral Presentation], Society for General Microbiology, Heriot-Watt University Edinburgh 7th-10th September 2009 , 07-SEP-09 - 10-SEP-09. [Details]
(2009)39th Annual research Conference, Food Nutrition and Consumer Sciences,,
Cormac GM Gahan; (2009) An introduction to the Alimentary Pharmabiotic Centre. [Invited Oral Presentation], 39th Annual research Conference, Food Nutrition and Consumer Sciences,, University College Cork , 03-SEP-09 - 04-SEP-09. [Details]
(2009)Conference on Listeria monocytogenes,
Cormac GM Gahan; (2009) Bioluminescence imaging: a new research tool for visualising Listeria in vivo. [Invited Oral Presentation], Conference on Listeria monocytogenes, Moorepark Food Research Centre , 21-SEP-09 - 22-SEP-09. [Details]
(2009)Society for General Microbiology,,
Cormac GM Gahan; (2009) Functional and comparative metagenomic analysis of bile salt hydrolase activity in the human gut microbiome: pathogens & commensals. [Oral Presentation], Society for General Microbiology,, Harrogate, UK , 30-MAR-09 - 02-APR-09. [Details]
(2009)All Ireland Schools of Pharmacy Conference,
Mohammed Bahey-El-Din, Pat G Casey, Brendan T Griffin and Cormac GM Gahan. ; (2009) Lactococcus lactis beyond the food industry: A promising delivery vector for antigens, immunomodulatory and therapeutic proteins. [Poster Presentation], All Ireland Schools of Pharmacy Conference, Ireland , 27-APR-09 - 27-APR-09. [Details]
(2009)FEMS 2009 Microbiology Congress,
Broaders E, Gahan CG, Marchesi JR. Winner best poster; (2009) Investigation and characterisation of plasmid DNA from the healthy human gut. [Poster Presentation], FEMS 2009 Microbiology Congress, Gothenburg, Sweden , 28-JUN-09 - 02-JUL-09. [Details]
(2009)Invited seminar,
Cormac GM Gahan; (2009) Real-time bioluminescence imaging applications in models of microbial pathogenesis. [Invited Seminars/Guest Lectures], Invited seminar, School of Pharmacy, University of Brighton, UK , 15-APR-09 - 15-APR-09. [Details]
(2009)Invited Seminar,
Cormac GM Gahan; (2009) Microbial bile salt degradation in the human GI tract: from commensals to cheats and pathogens. [Invited Seminars/Guest Lectures], Invited Seminar, Department of Microbiology, Trinity College Dublin, , 06-MAR-09 - 06-MAR-09. [Details]
(2009)Invited Seminar,
Cormac GM Gahan; (2009) Bioluminescence imaging: a new research tool for visualising Listeria monocytogenes in vivo. [Invited Seminars/Guest Lectures], Invited Seminar, Department of Microbiology, NUI Galway , 04-DEC-09 - 04-DEC-09. [Details]
(2009)Invited Seminar,
Cormac GM Gahan; (2009) Beginning to see the light: bioluminescence imaging of bacterial infections. [Invited Seminars/Guest Lectures], Invited Seminar, School of Pharmacy, UCC , 15-DEC-09 - 15-DEC-09. [Details]
(2009)FEMS 2009 Microbiology Congress,
McLaughlin, H, Sleator RD, Hill C and Gahan CG; (2009) Characterization of an MgtC-like Protein in L. monocytogenes EGDe. [Poster Presentation], FEMS 2009 Microbiology Congress, Gothenburg, Sweden , 28-JUN-09 - 02-JUL-09. [Details]
(2009)FEMS 2009 Microbiology Congress,
Dowd CG, Hill C and Gahan CG; (2009) Investigation of the molecular mechanisms by which Listeria monocytogenes grows in the mammalian gall bladder. [Poster Presentation], FEMS 2009 Microbiology Congress, Gothenburg, Sweden , 28-JUN-09 - 02-JUL-09. [Details]
(2009)Society for General Microbiology,
Mohammed Bahey-El-Din, Pat G Casey, Brendan T Griffin and Cormac GM Gahan; (2009) Lactococcus lactis beyond the food industry: A promising delivery vector for antigens, immunomodulatory and therapeutic proteins. [Poster Presentation], Society for General Microbiology, University College Cork , 23-APR-09 - 24-APR-09. [Details]

Committees

 CommitteeFunctionFrom / To
Research & Graduate Studies Pharmacy Member/
Research Committee Microbiology Member/
Research Quality Review Committee Microbiology Member/
Seminar Series Co-ordinator Microbiology Co-ordinator/
Microbe-Host Interactions UREKA Site Co-ordinator/

Employment

 EmployerPositionFrom / To
University College Cork Post-Doctoral Researcher02-JAN-95 / 01-JAN-97
University College Cork HRB Post-Doctoral Fellow01-JAN-98 / 01-JAN-02
University College Cork Temporary Lecturer01-SEP-02 / 01-SEP-04
University College Cork Lecturer (Above the bar)01-SEP-04 /

Education

 YearInstituionQualificationSubject
1990University College Cork BSCUnknown
1996University College Cork PHDUnknown

Outreach Activities

 Description

Outreach activities through the Alimentary Pharmabiotic Centre (http://apc.ucc.ie) include: School visits, School lectures (leaving cert), UREKA Microbe-Host Interactions Site

 StudentDegree TypePrimary
Nolan James Anthony Doctoral DegreeYes
 Term (ID))TitleLinkSubject
2015Advanced Immunology MB4009Advanced Immunology
2015Advanced Medical Microbiology MB4007Advanced Medical Microbiology
2015Literature Project on Genetics GN3002Literature Project on Genetics
2015Research Project MB4002Research Project
2015Research Frontiers in Microbiology MB4027Research Frontiers in Microbiology
2015Biopharmaceuticals: Formulation Design, Secondary Processing and Regulatory compliance PF6301Biopharmaceuticals: Formulation Design, Secondary Processing and Regulatory compliance
2015Clinical Microbiology PF3444Clinical Microbiology
2015Microbiology MB2444Microbiology