Deputy Director of Graduate Entry Medicine
Medical School
Rm 4.22
Food Science Building, School of Microbiology
University College Cork
Cork
Ireland

T: +353-21-490-2642
E: j.macsharry@ucc.ie

Alimentary Pharmabotic Centre (Apc)

Dr John Mac Sharry graduated with a B.Sc. in Microbiology and a Ph.D. in Mucosal Immunology from University College Cork. He worked with Alimentary Health Ltd as Molecular Biology section head collaborating with several multinational research partners. In 2008 he joined the APC Host Response core as a Post-Doctoral researcher and collaborated on research with GlaxoSmithKline. John was a guest researcher at the Meakins Christie Laboratories, McGill University in Montreal, Canada as part of an SFI fellowship in 2009 and 2010. John has also lectured and supervised part-time in the CIT. John was recently appointed as a Lecturer in Molecular Microbiology and Assistant director of the GEM programme with the School of Medicine with an affiliation to the School ofMicrobiology. His research interests are in host-microbe interactions with particular focus on the immune sampling and response in the gut and the lungs.


E-mail:j.macsharry@ucc.ie

Web: http://www.ucc.ie/en/medical/gradentry/

Research Interests

I am interested in the role mucosal immune sampling plays in systemic immune processes, with particular focus on the areas of host commensal/pathogen interactions. My main areas of scientific interest is in the interactions of the microbes with human host and the engagement with the immune system with particular interest in the interactions of commensal and pathogenic microbes with the mucosal immune system of both the gut and lung.  I have studied the areas of bacterial sampling via M cells in the intestine have also worked on the role of probiotic commensals in various in vitro and animal models of inflammation and immune disease. I have also performed human biopsy studies to determine and differentiate the gene expression and cytokine signature of IBD and IBS patients. Through collaboration with Prof James G. Martin, in Montreal, Canada, and Dr Des Murphy in CUH I have developed an interest in Asthma and the role of bacterial feeding on lung immunology and also the study of the microbial ecology of the lung.  As a Post Doctoral Scientist in the APC I developed a model of mucosal dendritic cells and we deciphered the unique mRNA and miRNA expression profiles of these cells using microarray and bioinformatic methods.  In collaboration with GSK we studied drug  mechanisms of action using gene expression, protein, flow cytometric, CHiP and microscopy techniques. I would like to bring these skill sets together to study role of the immune system in disease linking the mucosal and systemic immune system to understand the tolerance to antigen load at the mucosal barrier and the reactivity in the systemic site.

Peer Reviewed Journals

YearPublication
(2014)'The single intradermal cervical comparative test interferes with Johne’s disease ELISA diagnostics'
Kennedy, Aideen E and Da Silva, Ana T and Byrne, Noel and Govender, Rodney and MacSharry, John and O’Mahony, Jim and Sayers, Riona G (2014) 'The single intradermal cervical comparative test interferes with Johne’s disease ELISA diagnostics'. Molecular Innate Immunity, 5 [Details]
(2014)'Tracing innate immune defences along the path of Listeria monocytogenes infection'
Regan T, Macsharry J, Brint E (2014) 'Tracing innate immune defences along the path of Listeria monocytogenes infection'. Immunology And Cell Biology, [DOI] [Details]
(2014)'TLR2 located in subcellular compartments negatively regulates TLR4-mediated inflammatory response of macrophages to internalized bacteria'
L Butto, S Melgar, J O'Callaghan, I Jeffery, H Harris, J MacSharry, F Shanahan, P O'Toole, K Nally (2014) 'TLR2 located in subcellular compartments negatively regulates TLR4-mediated inflammatory response of macrophages to internalized bacteria'. [Details]
(2014)'Activation of liver X receptor suppresses the production of the IL-12 family of cytokines by blocking nuclear translocation of NF-kappa Bp50'
Canavan, M,McCarthy, C,Ben Larbi, N,Dowling, JK,Collins, L,O'Sullivan, F,Hurley, G,Murphy, C,Quinlan, A,Moloney, G,Darby, T,MacSharry, J,Kagechika, H,Moynagh, P,Melgar, S,Loscher, CE (2014) 'Activation of liver X receptor suppresses the production of the IL-12 family of cytokines by blocking nuclear translocation of NF-kappa Bp50'. Innate Immunity, 20 :675-687 [DOI] [Details]
(2014)'Regulation of host weight gain and lipid metabolism by bacterial bile acid modification in the gut'
Joyce, SA,MacSharry, J,Casey, PG,Kinsella, M,Murphy, EF,Shanahan, F,Hill, C,Gahan, CGM (2014) 'Regulation of host weight gain and lipid metabolism by bacterial bile acid modification in the gut'. Proceedings of The National Academy of Sciences of The United States of America, 111 :7421-7426 [DOI] [Details]
(2014)'Concomitant Exposure to Ovalbumin and Endotoxin Augments Airway Inflammation but Not Airway Hyperresponsiveness in a Murine Model of Asthma'
Mac Sharry, John and Shalaby, Karim H and Marchica, Cinzia and Farahnak, Soroor and Chieh-Li, Tien and Lapthorne, Susan and Qureshi, Salman T and Shanahan, Fergus and Martin, James G (2014) 'Concomitant Exposure to Ovalbumin and Endotoxin Augments Airway Inflammation but Not Airway Hyperresponsiveness in a Murine Model of Asthma'. Plos One, 9 (6) [Details]
(2013)'Identification of TLR10 as a Key Mediator of the Inflammatory Response to Listeria monocytogenes in Intestinal Epithelial Cells and Macrophages'
Regan, T,Nally, K,Carmody, R,Houston, A,Shanahan, F,MacSharry, J,Brint, E (2013) 'Identification of TLR10 as a Key Mediator of the Inflammatory Response to Listeria monocytogenes in Intestinal Epithelial Cells and Macrophages'. Journal of immunology (Baltimore, Md. : 1950), 191 :6084-6092 [DOI] [Details]
(2013)'Bifidobacterium infantis suppression of Peyer's patch MIP-1 alpha and MIP-1 beta secretion during Salmonella infection correlates with increased local CD4+CD25+T cell numbers'
Scully, P,MacSharry, J,O'Mahony, D,Lyons, A,O'Brien, F,Murphy, S,Shanahan, F,O'Mahony, L (2013) 'Bifidobacterium infantis suppression of Peyer's patch MIP-1 alpha and MIP-1 beta secretion during Salmonella infection correlates with increased local CD4+CD25+T cell numbers'. Cell Immunology, 281 :134-140 [DOI] [Details]
(2013)'Bifidobacterium Infantis 35624 Administration and Peyer's Patch Immune Response Following Salmonella Infection: The Role of Regulatory T-Cells and Chemokine Secretion'
Scully, P.,MacSharry, J.,O'Mahony, D.,Murphy, S.,O'Brien, F.,Shanahan, F.,O'Mahony, L. (2013) 'Bifidobacterium Infantis 35624 Administration and Peyer's Patch Immune Response Following Salmonella Infection: The Role of Regulatory T-Cells and Chemokine Secretion'. Gastroenterology, 144 (55) Globe icon [Details]
(2013)'Codon optimisation to improve expression of a Mycobacterium avium ssp. paratuberculosis-specific membrane-associated antigen by Lactobacillus salivarius'
Johnston, Christopher and Douarre, Pierre E and Soulimane, Tewfik and Pletzer, Daniel and Weingart, Helge and MacSharry, John and Coffey, Aidan and Sleator, Roy D and O'Mahony, Jim (2013) 'Codon optimisation to improve expression of a Mycobacterium avium ssp. paratuberculosis-specific membrane-associated antigen by Lactobacillus salivarius'. Pathogens And Disease, 68 (1):27-38 [Details]
(2012)'Immunomodulatory effects of feeding with Bifidobacterium longum on allergen-induced lung inflammation in the mouse'
MacSharry, J,O'Mahony, C,Shalaby, KH,Sheil, B,Karmouty-Quintana, H,Shanahan, F,Martin, JG (2012) 'Immunomodulatory effects of feeding with Bifidobacterium longum on allergen-induced lung inflammation in the mouse'. Pulmonary Pharmacology & Therapeutics, 25 :325-334 [DOI] [Details]
(2012)'Influence of Adhesion and Bacteriocin Production by Lactobacillus salivarius on the Intestinal Epithelial Cell Transcriptional Response'
O'Callaghan, J,Butto, LF,MacSharry, J,Nally, K,O'Toole, PW (2012) 'Influence of Adhesion and Bacteriocin Production by Lactobacillus salivarius on the Intestinal Epithelial Cell Transcriptional Response'. Applied and Environmental Microbiology, 78 :5196-5203 [DOI] [Details]
(2012)'Bifidobacterial surface-exopolysaccharide facilitates commensal-host interaction through immune modulation and pathogen protection'
Fanning, S,Hall, LJ,Cronin, M,Zomer, A,MacSharry, J,Goulding, D,Motherway, MO,Shanahan, F,Nally, K,Dougan, G,van Sinderen, D (2012) 'Bifidobacterial surface-exopolysaccharide facilitates commensal-host interaction through immune modulation and pathogen protection'. Proceedings of The National Academy of Sciences of The United States of America, 109 :2108-2113 [DOI] [Details]
(2012)'Host-microbe interactions that facilitate gut colonization by commensal bifidobacteria'
Ventura, M.,Turroni, F.,Motherway, M. O.,MacSharry, J.,van Sinderen, D. (2012) 'Host-microbe interactions that facilitate gut colonization by commensal bifidobacteria'. Trends Microbiol, 20 (1010):467-76467 Globe icon [Details]
(2012)'Bifidobacterium infantis 35624 protects against salmonella-induced reductions in digestive enzyme activity in mice by attenuation of the host inflammatory response'
Symonds, Erin L and O'Mahony, Caitlin and Lapthorne, Susan and O'Mahony, David and Mac Sharry, John and O'Mahony, Liam and Shanahan, Fergus (2012) 'Bifidobacterium infantis 35624 protects against salmonella-induced reductions in digestive enzyme activity in mice by attenuation of the host inflammatory response'. Clinical and translational gastroenterology, 3 (5) [Details]
(2012)'The Sphingosine-1-Phosphate Analogue FTY720 Impairs Mucosal Immunity and Clearance of the Enteric Pathogen Citrobacter rodentium'
Murphy, C. T.,Hall, L. J.,Hurley, G.,Quinlan, A.,MacSharry, J.,Shanahan, F.,Nally, K.,Melgar, S. (2012) 'The Sphingosine-1-Phosphate Analogue FTY720 Impairs Mucosal Immunity and Clearance of the Enteric Pathogen Citrobacter rodentium'. Infect Immun, 80 (88):2712-27232712 Globe icon [Details]
(2012)'Differential intestinal M-cell gene expression response to gut commensals'
Lapthorne, S.,MacSharry, J.,Scully, P.,Nally, K.,Shanahan, F. (2012) 'Differential intestinal M-cell gene expression response to gut commensals'. Immunology, 136 (33):312-324312 Globe icon [Details]
(2012)'A Conserved Two-Component Signal Transduction System Controls the Response to Phosphate Starvation in Bifidobacterium breve UCC2003'
Alvarez-Martin, P,Fernandez, M,O'Connell-Motherway, M,O'Connell, KJ,Sauvageot, N,Fitzgerald, GF,MacSharry, J,Zomer, A,van Sinderen, D (2012) 'A Conserved Two-Component Signal Transduction System Controls the Response to Phosphate Starvation in Bifidobacterium breve UCC2003'. Applied and Environmental Microbiology, 78 :5258-5269 [DOI] [Details]
(2011)'Differential expression of toll-like receptors in patients with irritable bowel syndrome'
Brint EK, MacSharry J, Fanning A, Shanahan F, Quigley EM (2011) 'Differential expression of toll-like receptors in patients with irritable bowel syndrome'. The American Journal of Gastroenterology, 106 (2):329-336 [DOI] [Details]
(2011)'Cellodextrin utilization by Bifidobacterium breve UCC2003'
Pokusaeva, Karina and O'Connell-Motherway, Mary and Zomer, Aldert and MacSharry, John and Fitzgerald, Gerald F and van Sinderen, Douwe (2011) 'Cellodextrin utilization by Bifidobacterium breve UCC2003'. Applied and Environmental Microbiology, 77 (5):1681-1690 [Details]
(2010)'Function and efficacy of an {alpha}4-integrin antagonist using bioluminescence imaging to detect leukocyte trafficking in murine experimental colitis'
Murphy CT, Moloney G, Macsharry J, Haynes A, Faivre E, Quinlan A, McLean PG, Lee K, O'Mahony L, Shanahan F, Melgar S, Nally K. (2010) 'Function and efficacy of an {alpha}4-integrin antagonist using bioluminescence imaging to detect leukocyte trafficking in murine experimental colitis'. Journal of Leukocyte Biology, 88 (6):1271-1278 Globe icon [Details]
(2010)'Asymptomatic carriage of Clostridium difficile in an Irish continuing care institution for the elderly: prevalence and characteristics'
Ryan, J,Murphy, C,Twomey, C,Ross, RP,Rea, MC,MacSharry, J,Sheil, B,Shanahan, F (2010) 'Asymptomatic carriage of Clostridium difficile in an Irish continuing care institution for the elderly: prevalence and characteristics'. Irish Journal of Medical Science, 179 :245-250 [DOI] [Details]
(2010)'Differential regulation of Toll-like receptor signalling in spleen and Peyer's patch dendritic cells'
Davies, JM,MacSharry, J,Shanahan, F (2010) 'Differential regulation of Toll-like receptor signalling in spleen and Peyer's patch dendritic cells'. The Journal of Immunology, 131 :438-448 [DOI] [Details]
(2010)'Technical Advance: Function and efficacy of an alpha(4)-integrin antagonist using bioluminescence imaging to detect leukocyte trafficking in murine experimental colitis'
Murphy, CT,Moloney, G,MacSharry, J,Haynes, A,Faivre, E,Quinlan, A,McLean, PG,Lee, K,O'Mahony, L,Shanahan, F,Melgar, S,Nally, K (2010) 'Technical Advance: Function and efficacy of an alpha(4)-integrin antagonist using bioluminescence imaging to detect leukocyte trafficking in murine experimental colitis'. Journal of Leukocyte Biology, 88 :1271-1278 [DOI] [Details]
(2010)'Bacterial strain-specific induction of Foxp3+T regulatory cells is protective in murine allergy models'
Lyons, A; O'Mahony, D; O'Brien, F; MacSharry, J; Sheil, B; Ceddia, M; Russell, WM; Forsythe, P; Bienenstock, J; Kiely, B; Shanahan, F; O'Mahony, L; (2010) 'Bacterial strain-specific induction of Foxp3+T regulatory cells is protective in murine allergy models'. Allergy, 40 :811-819 [DOI] [Details]
(2010)'Differential expression of toll-like receptors in patients with irritable bowel syndrome'
Brint, Elizabeth K and MacSharry, John and Fanning, Aine and Shanahan, Fergus and Quigley, Eamonn MM (2010) 'Differential expression of toll-like receptors in patients with irritable bowel syndrome'. The American Journal of Gastroenterology, 106 (2):329-336 [Details]
(2010)'Ribose utilization by the human commensal Bifidobacterium breve UCC2003'
Pokusaeva, Karina and Neves, Ana Rute and Zomer, Aldert and O'Connell-Motherway, Mary and MacSharry, John and Curley, Peter and Fitzgerald, Gerald F and Van Sinderen, Douwe (2010) 'Ribose utilization by the human commensal Bifidobacterium breve UCC2003'. Microbial Biotechnology, 3 (3):311-323 [Details]
(2009)'Portrait of a canine probiotic Bifidobacterium-From gut to gut'
O'Mahony, D; Murphy, K. Barry; MacSharry, J; Boileau, T; Sunvold, G; Reinhart, G; Kiely, B; Shanahan, F; O'Mahony, L.; (2009) 'Portrait of a canine probiotic Bifidobacterium-From gut to gut'. Veterinary microbiology, 139 (1-2):106-112 [DOI] [Details]
(2009)'Differential Expression of Toll-Like Receptors (TLRS)in Irritable Bowel Syndrome (IBS)'
Brint, E.,MacSharry, J.,Shanahan, F.,Quigley, E. M. (2009) 'Differential Expression of Toll-Like Receptors (TLRS)in Irritable Bowel Syndrome (IBS)'. Gastroenterology, 136 (55) Globe icon [Details]
(2008)'Mucosal cytokine imbalance in irritable bowel syndrome'
Macsharry, J,O'Mahony, L,Fanning, A,Bairead, E,Sherlock, G,Tiesman, J,Fulmer, A,Kiely, B,Dinan, T,Shanahan, F,Quigley, E; (2008) 'Mucosal cytokine imbalance in irritable bowel syndrome'. Scandinavian Journal of Gastroenterology, 43 :1467-1476 [DOI] [Details]
(2008)'Commensal-Induced Regulatory T Cells Mediate Protection Against Pathogen-Stimulated Nf-Kappa B Activation'
O'Mahony, C, Scully, P, O'Mahony, D, Murphy, S, O'Brien, F, Lyons, A, Sherlock, G, MacSharry, J, Kiely, B, Shanahan, F, O'Mahony, L; (2008) 'Commensal-Induced Regulatory T Cells Mediate Protection Against Pathogen-Stimulated Nf-Kappa B Activation'. Plos Pathogens, 4 (8) [DOI] [Details]
(2007)'Modulation of the commensal flora by probiotic feeding delays the onset and decreases the severity of disease in the collagen-induced arthritis (CIA) model in a strain-dependent manner'
Sheil, B.,Macsharry, J.,O'mahony, L.,Shanahan, F.,Kiely, B. (2007) 'Modulation of the commensal flora by probiotic feeding delays the onset and decreases the severity of disease in the collagen-induced arthritis (CIA) model in a strain-dependent manner'. Gastroenterology, 132 (44) Globe icon [Details]
(2007)'Commensal microbiota, including probiotics, promote T regulatory cells and attenuation of inflammatory responses to murine Salmonella infection'
O'mahony, C.,Scully, P.,O'mahony, D.,Lyons, A.,O'sullivan, D.,Macsharry, J.,Kiely, B.,Shanahan, F.,O'mahony, L. (2007) 'Commensal microbiota, including probiotics, promote T regulatory cells and attenuation of inflammatory responses to murine Salmonella infection'. Gastroenterology, 132 (44) Globe icon [Details]
(2006)'Functional modulation of human intestinal epithelial cell responses by Bifidobacterium infantis and Lactobacillus salivarius'
O'Hara, AM,O'Regan, P,Fanning, A,O'Mahony, C,MacSharry, J,Lyons, A,Bienenstock, J,O'Mahony, L,Shanahan, F (2006) 'Functional modulation of human intestinal epithelial cell responses by Bifidobacterium infantis and Lactobacillus salivarius'. The Journal of Immunology, 118 :202-215 [DOI] [Details]
(2006)'Consumption of the probiotic Bifidobacterium infantis 35624 influences subsequent immune responses to in vitro challenge of isolated murine Peyer's patch cells with bacterial stimuli'
Shed, B.,MacSharry, J.,O'Callaghan, L.,O'Riordan, A.,Waters, A.,Morgan, J.,Collins, J. K.,O'Mahony, L.,Shanahan, F. (2006) 'Consumption of the probiotic Bifidobacterium infantis 35624 influences subsequent immune responses to in vitro challenge of isolated murine Peyer's patch cells with bacterial stimuli'. Gastroenterology, 130 (44) Globe icon [Details]
(2006)'Role of interleukin (IL-10) in probiotic-mediated immune modulation: an assessment in wild-type and IL-10 knock-out mice'
Sheil, B,MacSharry, J,O'Callaghan, L,O'Riordan, A,Waters, A,Morgan, J,Collins, JK,O'Mahony, L,Shanahan, F; (2006) 'Role of interleukin (IL-10) in probiotic-mediated immune modulation: an assessment in wild-type and IL-10 knock-out mice'. Clinical and Experimental Immunology, 144 :273-280 [DOI] [Details]
(2005)'Changes in the immunoregulatory gene profile in ibs subjects following problotic treatment: Investigating a mechanism of action'
Bairead, E.,MacSharry, J.,Scully, P.,Fanning, A.,Kiely, B.,O'Mahony, S.,Shanahan, F.,O'Mahony, L.,Quigley, E. (2005) 'Changes in the immunoregulatory gene profile in ibs subjects following problotic treatment: Investigating a mechanism of action'. Endoscopy, 37 (1212):1270-12821270 Globe icon [Details]
(2005)'Serial culture-independent analysis of the enteric microbial community in Crohn's disease and disease controls'
Marchesi, J.,Scanlan, P.,Codling, C.,MacSharry, J.,Kiely, B.,O'Mahony, L.,Collins, J. K.,Quigley, E.,Shanahan, F. (2005) 'Serial culture-independent analysis of the enteric microbial community in Crohn's disease and disease controls'. Gastroenterology, 128 (44) Globe icon [Details]
(2005)'Alterations in immunological gene expression from colonic biopsies of female IBS patients following probintic consumption'
Bairead, E.,O'Mahony, L.,MacSharry, J.,Scully, P.,Fanning, A.,Kiely, B.,O'Mahony, S.,Shanahan, F.,Quigley, E. (2005) 'Alterations in immunological gene expression from colonic biopsies of female IBS patients following probintic consumption'. Gastroenterology, 128 (44) Globe icon [Details]
(2005)'Modulatory impact of commensal probiotics on intestinal epithelial cell responses to pro-inflammatory stimuli'
O'Hara, A.,Fanning, A.,Caitlin, O.,O'Regan, P.,MacSharry, J.,O'Mahony, L.,Shanahan, F. (2005) 'Modulatory impact of commensal probiotics on intestinal epithelial cell responses to pro-inflammatory stimuli'. Gastroenterology, 128 (44) Globe icon [Details]
(2005)'Effect of probiotic feeding on Salmonella translocation in a mouse model'
Sommerfield, D.,MacSharry, J.,O'Mahony, D.,O'Mahony, L.,Kiely, B.,Shanahan, F.,Quigley, E. (2005) 'Effect of probiotic feeding on Salmonella translocation in a mouse model'. Gastroenterology, 128 (44) Globe icon [Details]
(2004)'Mechanism of probiotic/commensal mediated protection against invasive salmonella infection'
O'Mahony, L.,Sheil, B.,MacSharry, J.,O'Callaghan, L.,Collins, J. K.,O'Sullivan, G.,Kiely, B.,Shanahan, F. (2004) 'Mechanism of probiotic/commensal mediated protection against invasive salmonella infection'. Gastroenterology, 126 (44) Globe icon [Details]
(2004)'Cytokine responses in different lymphoid compartments in IL-10/ko mice fed Bifidobacterium infantis'
O'Callaghan, L.,Sheil, B.,MacSharry, J.,Collins, J. K.,O'Mahony, L.,Shanahan, F. (2004) 'Cytokine responses in different lymphoid compartments in IL-10/ko mice fed Bifidobacterium infantis'. Gastroenterology, 126 (44) Globe icon [Details]
(2003)'Diversity of epithelial cell gene expression in response to different lactobacilli'
O'Regan, P.,Powers, A.,Macsharry, J.,Kiely, B.,Collins, J. K.,O'Mahony, L.,Shanahan, F. (2003) 'Diversity of epithelial cell gene expression in response to different lactobacilli'. Gastroenterology, 124 (44) Globe icon [Details]
(2003)'Plasticity of epithelial cell cytokine responses to commensal and pathogenic species'
O'Regan, P.,Powers, A.,Macsharry, J.,O'Sullivan, G.,Kiely, B.,Collins, J. K.,O'Mahony, L.,Shanahan, F. (2003) 'Plasticity of epithelial cell cytokine responses to commensal and pathogenic species'. Gastroenterology, 124 (44) Globe icon [Details]
(2000)'Probiotics, mononuclear cells, and epithelial cells: An anti-inflammatory network'
O'Mahony, L.,Feeney, M.,MacSharry, J.,Kiely, B.,McCarthy, J.,O'Sullivan, G. C.,Shanahan, F. L.,Collins, J. K. (2000) 'Probiotics, mononuclear cells, and epithelial cells: An anti-inflammatory network'. Gastroenterology, 118 (44) Globe icon [Details]

Conference Publications

YearPublication
(2013)Immunology 2013
Regan, T.,Nally, K.,Brint, E.,MacSharry, J. (2013) Toll-like receptor 10 mediates the inflammatory response to Listeria monocytogenes infection Immunology 2013 Globe icon [Details]
(2013)ICMI Vancouver, Canada 2013
J Mac Sharry et al (2013) Disconnect between LPS-induced cytokine mRNAs and secreted protein in Dendritic cells tolerised by intestinal Epithelia ICMI Vancouver, Canada 2013 [Details]
(2012)DDW 2012; Gastroenterology
Fanning, A.,Moloney, G.,MacSharry, J.,Ambrose, M.,Quigley, E. M.,Shanahan, F.,Melgar, S.,Nally, K. (2012) Elevated Expression of the Cytosolic DNA Sensors AIM2 and ZBP1/DAI in Active Ulcerative Colitis but Not Crohn's Disease Colonic Tissue DDW 2012; Gastroenterology Globe icon [Details]
(2012)DDW 2012; Gastroenterology
Fanning, A.,Moloney, G.,MacSharry, J.,Ambrose, M.,Prinjha, R.,Lee, K.,Quigley, E. M.,Shanahan, F.,Melgar, S.,Nally, K. (2012) Differential Expression of Epigenetic Modifier Genes in Inflammatory Bowel Disease Colonic Tissue-PRDM1 and PRDM8 are up-Regulated in Active Ulcerative Colitis DDW 2012; Gastroenterology Globe icon [Details]
(2012)EMIG
J Mac Sharry et al (2012) Disconnect between LPS-induced cytokine mRNAs and secreted protein in Dendritic cells tolerised by intestinal Epithelia EMIG [Details]
(2012)FASEB JOURNAL
Mitmesser, Susan Hazels and Russell, William Michael and O'Mahony, David and MacSharry, John and Ceddia, Michael and O'Mahony, Liam (2012) BACTERIAL STRAIN-SPECIFIC EFFECTS ON IMMUNE MARKERS IN RSV INFECTED MICE FASEB JOURNAL [Details]
(2012)FASEB JOURNAL
Mitmesser, Susan Hazels and Russell, William Michael and O'Mahny, David and MacSharry, John and Lyons, Anne and Ceddia, Michael and O'Mahony, Liam (2012) EFFECTS OF SELECT HUMAN MICROBES ON CITROBACTER RODENTIUM INFECTION IN MICE FASEB JOURNAL [Details]
(2011)DDW 2011; Gastroenterology
Lapthorne, S.,MacSharry, J.,Scully, P.,Nally, K.,Shanahan, F. (2011) The Discriminatory Intelligence of M Cells - Beyond a Simple Translocation Portal DDW 2011; Gastroenterology Globe icon [Details]
(2006)DDW 2006; Gastroenterology
Nally, K.,O'Brien, D.,MacSharry, J.,Bairead, E.,O'Sullivan, G. C.,O'Connell, J.,Shanahan, F. (2006) IFN gamma and TNF alpha synergize to induce maximal NF-kappa B activation, NF-kappa B mediated trail expression and apoptosis of colonic epithelial cells DDW 2006; Gastroenterology Globe icon [Details]

Abstract

YearPublication
(2013)Toll-like receptor 10 mediates the inflammatory response to Listeria monocytogenes infection.
Regan, T,Nally, K,Brint, E,MacSharry, J (2013) Toll-like receptor 10 mediates the inflammatory response to Listeria monocytogenes infection. Abstract [Details]
(2000)Probiotics, mononuclear cells, and epithelial cells: An anti-inflammatory network.
O'Mahony, L,Feeney, M,MacSharry, J,Kiely, B,McCarthy, J,O'Sullivan, GC,Shanahan, FL,Collins, JK (2000) Probiotics, mononuclear cells, and epithelial cells: An anti-inflammatory network. Abstract [Details]

Book Reviews

YearPublication
(2012)Host-microbe interactions that facilitate gut colonization by commensal bifidobacteria.
Ventura, M,Turroni, F,Motherway, MO,MacSharry, J,van Sinderen, D (2012) Host-microbe interactions that facilitate gut colonization by commensal bifidobacteria. Book Reviews [DOI] [Details]

Reviews

YearPublication
(2014)Tracing innate immune defences along the path of Listeria monocytogenes infection.
Regan, T,MacSharry, J,Brint, E (2014) Tracing innate immune defences along the path of Listeria monocytogenes infection. Reviews [DOI] [Details]

Honours and Awards

 YearTitleAwarding Body
2011Best Poster award Irish Society Of Immunology
2008ERS Young Scientist Award European Respiratory Society
2009SFI Short Term Travel Fellowship SFI

Professional Associations

 AssociationFunctionFrom / To
Society For Mucosal Immunology Member/

Patents

 Patent NumberTitleInventorGranted
US 8557233 B2Probiotic bifidobacterium strains John MacSharry Liam O'Mahony David O'Sullivan Barry Kiely31-OCT-13
WO 2008117267 AProbiotic bifidobacterium strains Barry Kiely, John Macsharry, Liam O'mahony, David O'sullivan27-NOV-08
CA 2607949 CFeline probiotic bifidobacteria Thomas William-Maxwell Boileau, Barry Pius Kiely, Liam Diarmuid O'mahony, John Macsharry, Gregory Dean Sunvold, The Iams Company, Alimentary Health Ltd.25-SEP-12

Committees

 CommitteeFunctionFrom / To
Graduate Entry to Medicine Working group GEM Deputy Director2014 /
Graduate Entry to Medicine (GEM) Teaching and Oversight Committee Deputy Director2013 /

Employment

 EmployerPositionFrom / To
CIT Part time Lecturer01-SEP-12 / 31-JAN-13
School of Medicine, UCC Deputy Director of Graduate Entry Medicine, Lecturer in Molecular Medical Microbiology01-FEB-13 /
Alimentary Health Ltd. Molecular Biology Section Head01-FEB-03 / 30-APR-08
UCC Research fellow01-MAY-08 / 31-JAN-13
UCC Post Doctoral Researcher01-FEB-01 / 31-JAN-03

Languages

 LanguageReadingWritingSpeaking
French BasicBasicFunctional

Consultancy

 ClientDescription
Smart cells
Adipocyte Screening Assay consultant

Outreach Activities

 Description

Educational  School visits to Scoil Padraig Naofa, Rochestown, Cork

Primary School Science visits and presentations with the APC Ed&O team

Other Activities

 Description

External Examiner for MSc in Computational Biology (CIT, Cork, Ireland)

External Examiner for PhD (University of British Columbia, Canada)

Internal Examiner for MSc and PhD (UCC)

Teaching Interests

Medical Microbiology Mucosal Immunology

UCC Modules Contributed to: 


Undergraduate:


MB4002: 4th Year Microbiology Research Project
MB4027: Research Frontiers in Microbiology

MB4009: Current Advances in Immunology

MB3016: Microbiology 3rd Year Literature Project

Postgraduate:

Graduate Entry to Medicine:

GM1001: Fundamentals of Medicine I

GM1002: Fundamentals of Medicine II

GM1003: Fundamentals of Medicine III

GM2001: Fundamentals of Medicine IV

School of Medicine USMLE Supplementary Tutorials


Recent Postgraduates

 Graduation YearStudent NameInstitutionDegree TypeThesis Title
2014Tim Regan UCCPhDIdentification of Novel Innate Immune Mechanisms Regulating Inflammation in the Gastrointestinal Tract

Internal Collaborators

 NameInstituteCountry
Prof Mike Prentice Pathology, UCCIRELAND
Dr Des Murphy CUHIRELAND
Dr Mary O'Connell Motherway UCCIRELAND
Prof Fergus Shanahan CUHIRELAND
Dr Beth Brint UCCIRELAND
Dr Cormac Gahan UCCIRELAND
Dr Ger O'Keefe UCCIRELAND

External Collaborators

 NameOrganisation/ InstitutionCountry
Dr Lindsay Hall Norwich Medical SchoolUNITED KINGDOM
Dr Ed Lavelle TCDIRELAND
Dr Christian Reidel University of UlmGERMANY
Dr Chris Ward Newcastle UniversityUNITED KINGDOM
Dr Aidan Coffey CITIRELAND
Dr Jim O'Mahony CITIRELAND
Prof James G Martin McGill UniversityCANADA