Professor
Microbiology
University College Cork
Cork
Ireland

T: +353-21-490-3000
F: +353 21 490 3997
E: pwotoole@ucc.ie
Web Page

The overall goal of my research is the understanding of bacterial associations with the human gut, and how this impacts on health and disease. Though different bacterial species are examined, there is a unifying theme of genetics, genomics and metagenomics to investigate how bacteria colonize, persist and interact in the human gut.

Lactobacillus.

In collaboration with colleagues at UCC and the Alimentary Pharmabiotic Research Centre, we are using functional genomics to identify genes and proteins which contribute to the probiotic effect exerted by these bacteria. To accomplish this, we have sequenced the genome of Lactobacillus salivarius UCC118. We have completed a bioinformatics analysis of putative adhesins and surface proteins, and we have tested their function by gene knock-outs and a variety of functional assays. We are using custom microarrays for global transcript analysis, and developing genetic tools to facilitate functional assay of genes and proteins suspected of involvement in host interaction. Using L. salivarius as a discovery platform, we are extending these analyses to other commensal or probiotic lactobacilli, and we are re-examining the classification of Lactobacilli based upon phylogenomic approaches. We are also developing a metagenomics platform, to allow us to determine the effect of selected commensal bacteria on gut flora in model systems. The lactobacillus sequencing activity from my lab is acknowledged as at the forefront of the field by invited reviews and conference talks.

Helicobacter pylori.

We are using molecular genetics, biochemistry, and structural biology (X-ray crystallography) to study how flagellar proteins interact to accomplish export and controlled assembly of the flagellum on the cell surface. We are currently examining the production and export of adhesins of Helicobacter pylori, using a combination of microarrays, proteomics, high-throughput mutagenesis, and in vitro adhesion assay. In collaboration with the Pathogen Sequencing Unit of the Wellcome Trust Sanger Institute, we are undertaking a genomic analysis of Helicobacter mustelae (http://www.sanger.ac.uk/Projects/H_mustelae). H. mustelae infection of ferrets is the only natural model of Helicobacter-associated ulcer disease. Comparative and functional genomic studies will provide new insights into the molecular pathogenesis of human gastric disease. My lab is one of a small number that leads publications on H. pylori motility studies.

Metagenomics.

I am a PI in the ELDERMET project which is a metagenomics analysis of the intestinal microbiota in several hundred elderly subjects. I am currently negotiating membership of this project in the International Human Microbiome Consortium. This will put the Irish national metagenomics project at the forefront of international initiatives in this area.

Book Chapters

 YearPublication
(2009)'Comparative and functional genomics of the genus Lactobacillus'
Van Pijkeren, J-P., and P.W. O¿Toole. ; (2009) 'Comparative and functional genomics of the genus Lactobacillus' In: A. Ljungh, and T. Wadstrom (eds). Lactobacillus Molecular Biology: From Genomics to Probiotics. Norfolk, UK: Caister Academic Press. [No details]
(2008)'The influence of probiotics on the intestinal microbiota'
O¿Toole, P.W. and J.C. Cooney. ; (2008) 'The influence of probiotics on the intestinal microbiota' In: Koch. V.B. Young, and R.A. Britton (eds). The Human Microbiome and Infectious Diseases: Beyond. '': Interdisc. Perspect. Inf. Dis. [No details]
(2001)'H. pylori Cell Envelope'
O’Toole, P.W. Clyne, M.; (2001) 'H. pylori Cell Envelope' In: Mobley, H.L.T. Hazell, S. Mendz, G (eds). Helicobacter pylori: Physiology and Genetics. [No details]
(1997)'Molecular characterization of H. pylori surface antigens'
Doig, P., O'Toole, P.W. Trust, T.J.; (1997) 'Molecular characterization of H. pylori surface antigens' In: Clayton, C.L. Mobley, H.L.T (eds). Helicobacter pylori protocols; Methods in Molecular Medicine. [No details]
(1988)'Construction of gene libraries in bacteriophage lambda vectors. In ed.'s. Elsevier Amsterdam, New York'
O'Toole, P. W. Foster, T.J.; (1988) 'Construction of gene libraries in bacteriophage lambda vectors. In ed.'s. Elsevier Amsterdam, New York' In: Owen, P. Foster, T.J (eds). Immunochemical and molecular genetic analysis of bacterial pathogens. [No details]
(1988)'Screening lambda libraries and detection of recombinants'
O'Reilly, M. O'Toole, P.W. Foster, T.J.; (1988) 'Screening lambda libraries and detection of recombinants' In: Owen, P. Foster, T.J (eds). Immunochemical and molecular genetic analysis of bacterial pathogens. [No details]
(1988)'Genetic analysis of Staphylococcus aureus virulence'
Foster, T, J.O'Toole, P.W.O'Reilly, M.; (1988) 'Genetic analysis of Staphylococcus aureus virulence' In: * (eds). FEMS Symposium 40 (Immunochem. Mol. Genet. Anal. Bact. Pathog.). '': ''. [No details]

Peer Reviewed Journals

 YearPublication
(2006)'Diversity of the genus Lactobacillus revealed by comparative genomics of five species'
Canchaya C, Claesson MJ, Fitzgerald GF, van Sinderen D, O'Toole PW (2006) 'Diversity of the genus Lactobacillus revealed by comparative genomics of five species' [Details]
(2006)'Multireplicon genome architecture of Lactobacillus salivarius'
Claesson MJ, Li Y, Leahy S, Canchaya C, van Pijkeren JP, Cerdeño-Tárraga AM, Parkhill J, Flynn S, O'Sullivan GC, Collins JK, Higgins D, Shanahan F, Fitzgerald GF, van Sinderen D, O'Toole PW (2006) 'Multireplicon genome architecture of Lactobacillus salivarius' [Details]
(2007)'The genus Lactobacillus--a genomic basis for understanding its diversity'
Claesson MJ, van Sinderen D, O'Toole PW (2007) 'The genus Lactobacillus--a genomic basis for understanding its diversity' [Details]
(2008)'Lactobacillus phylogenomics--towards a reclassification of the genus'
Claesson MJ, van Sinderen D, O'Toole PW (2008) 'Lactobacillus phylogenomics--towards a reclassification of the genus' [Details]
(2008)'Characterization of endogenous plasmids from Lactobacillus salivarius UCC118'
Fang F, Flynn S, Li Y, Claesson MJ, van Pijkeren JP, Collins JK, van Sinderen D, O'Toole PW (2008) 'Characterization of endogenous plasmids from Lactobacillus salivarius UCC118' [Details]
(2009)'Comparative analysis of pyrosequencing and a phylogenetic microarray for exploring microbial community structures in the human distal intestine'
Claesson MJ, O'Sullivan O, Wang Q, Nikkilä J, Marchesi JR, Smidt H, de Vos WM, Ross RP, O'Toole PW (2009) 'Comparative analysis of pyrosequencing and a phylogenetic microarray for exploring microbial community structures in the human distal intestine' [Details]
(2010)'Gut microbiota: Changes throughout the lifespan from infancy to elderly'
O'Toole PW, Claesson MJ (2010) 'Gut microbiota: Changes throughout the lifespan from infancy to elderly' [Details]
(2011)'Correlation of rRNA gene amplicon pyrosequencing and bacterial culture for microbial compositional analysis of faecal samples from elderly Irish subjects'
O'Sullivan Ó, Coakley M, Lakshminarayanan B, Claesson MJ, Stanton C, O'Toole PW, Ross RP (2011) 'Correlation of rRNA gene amplicon pyrosequencing and bacterial culture for microbial compositional analysis of faecal samples from elderly Irish subjects' [DOI] [Details]
(2011)'Composition, variability, and temporal stability of the intestinal microbiota of the elderly'
Claesson, MJ,Cusack, S,O'Sullivan, O,Greene-Diniz, R,de Weerd, H,Flannery, E,Marchesi, JR,Falush, D,Dinan, T,Fitzgerald, G,Stanton, C,van Sinderen, D,O'Connor, M,Harnedy, N,O'Connor, K,Henry, C,O'Mahony, D,Fitzgerald, AP,Shanahan, F,Twomey, C,Hill, C,Ross, RP,O'Toole, PW (2011) 'Composition, variability, and temporal stability of the intestinal microbiota of the elderly' [DOI] [Details]
(2011)'Functional genome analysis of Bifidobacterium breve UCC2003 reveals type IVb tight adherence (Tad) pili as an essential and conserved host-colonization factor'
O'Connell Motherway M, Zomer A, Leahy SC, Reunanen J, Bottacini F, Claesson MJ, O'Brien F, Flynn K, Casey PG, Munoz JA, Kearney B, Houston AM, O'Mahony C, Higgins DG, Shanahan F, Palva A, de Vos WM, Fitzgerald GF, Ventura M, O'Toole PW, van Sinderen D (2011) 'Functional genome analysis of Bifidobacterium breve UCC2003 reveals type IVb tight adherence (Tad) pili as an essential and conserved host-colonization factor' [Details]
(2011)'Composition, variability, and temporal stability of the intestinal microbiota of the elderly'
Claesson MJ, Cusack S, O'Sullivan O, Greene-Diniz R, de Weerd H, Flannery E, Marchesi JR, Falush D, Dinan T, Fitzgerald G, Stanton C, van Sinderen D, O'Connor M, Harnedy N, O'Connor K, Henry C, O'Mahony D, Fitzgerald AP, Shanahan F, Twomey C, Hill C, Ross RP, O'Toole PW (2011) 'Composition, variability, and temporal stability of the intestinal microbiota of the elderly' [Details]
(2012)'Diversity of Bifidobacteria within the Infant Gut Microbiota'
Turroni, F,Peano, C,Pass, DA,Foroni, E,Severgnini, M,Claesson, MJ,Kerr, C,Hourihane, J,Murray, D,Fuligni, F,Gueimonde, M,Margolles, A,De Bellis, G,O'Toole, PW,van Sinderen, D,Marchesi, JR,Ventura, M (2012) 'Diversity of Bifidobacteria within the Infant Gut Microbiota' [DOI] [Details]
(2012)'gamma-Aminobutyric acid production by culturable bacteria from the human intestine'
Barrett, E,Ross, RP,O'Toole, PW,Fitzgerald, GF,Stanton, C (2012) 'gamma-Aminobutyric acid production by culturable bacteria from the human intestine' [DOI] [Details]
(2012)'Characterization of Pro-Inflammatory Flagellin Proteins Produced by Lactobacillus ruminis and Related Motile Lactobacilli'
Neville, BA,Forde, BM,Claesson, MJ,Darby, T,Coghlan, A,Nally, K,Ross, RP,O'Toole, PW (2012) 'Characterization of Pro-Inflammatory Flagellin Proteins Produced by Lactobacillus ruminis and Related Motile Lactobacilli' [DOI] [Details]
(2012)'Changes in the intestinal microbiota from adulthood through to old age'
O'Toole, PW (2012) 'Changes in the intestinal microbiota from adulthood through to old age' [DOI] [Details]
(2012)'An irritable bowel syndrome subtype defined by species-specific alterations in faecal microbiota'
Jeffery, IB,O'Toole, PW,Ohman, L,Claesson, MJ,Deane, J,Quigley, EMM,Simren, M (2012) 'An irritable bowel syndrome subtype defined by species-specific alterations in faecal microbiota' [DOI] [Details]
(2012)'Resource partitioning in relation to cohabitation of Lactobacillus species in the mouse forestomach'
Tannock, GW,Wilson, CM,Loach, D,Cook, GM,Eason, J,O'Toole, PW,Holtrop, G,Lawley, B (2012) 'Resource partitioning in relation to cohabitation of Lactobacillus species in the mouse forestomach' [DOI] [Details]
(2012)'Effect of Lactobacillus salivarius Bacteriocin Abp118 on the Mouse and Pig Intestinal Microbiota'
Riboulet-Bisson, E,Sturme, MHJ,Jeffery, IB,O'Donnell, MM,Neville, BA,Forde, BM,Claesson, MJ,Harris, H,Gardiner, GE,Casey, PG,Lawlor, PG,O'Toole, PW,Ross, RP (2012) 'Effect of Lactobacillus salivarius Bacteriocin Abp118 on the Mouse and Pig Intestinal Microbiota' [DOI] [Details]
(2012)'Draft Genome Sequences of Helicobacter pylori Strains 17874 and P79'
Clancy, CD,Forde, BM,Moore, SA,O'Toole, PW (2012) 'Draft Genome Sequences of Helicobacter pylori Strains 17874 and P79' [DOI] [Details]
(2012)'Influence of Adhesion and Bacteriocin Production by Lactobacillus salivarius on the Intestinal Epithelial Cell Transcriptional Response'
O'Callaghan, J,Butto, LF,MacSharry, J,Nally, K,O'Toole, PW (2012) 'Influence of Adhesion and Bacteriocin Production by Lactobacillus salivarius on the Intestinal Epithelial Cell Transcriptional Response' [DOI] [Details]
(2012)'Mechanism of protection of transepithelial barrier function by Lactobacillus salivarius: strain dependence and attenuation by bacteriocin production'
Miyauchi, E,O'Callaghan, J,Butto, LF,Hurley, G,Melgar, S,Tanabe, S,Shanahan, F,Nally, K,O'Toole, PW (2012) 'Mechanism of protection of transepithelial barrier function by Lactobacillus salivarius: strain dependence and attenuation by bacteriocin production' [DOI] [Details]
(2012)'Diversity of bifidobacteria within the infant gut microbiota'
Turroni, F.,Peano, C.,Pass, D. A.,Foroni, E.,Severgnini, M.,Claesson, M. J.,Kerr, C.,Hourihane, J.,Murray, D.,Fuligni, F.,Gueimonde, M.,Margolles, A.,De Bellis, G.,O'Toole, P. W.,van Sinderen, D.,Marchesi, J. R.,Ventura, M. (2012) 'Diversity of bifidobacteria within the infant gut microbiota' [Details]
(2012)'Alterations in intestinal microbiota of elderly Irish subjects post-antibiotic therapy'
O'Sullivan, O.,Coakley, M.,Lakshminarayanan, B.,Conde, S.,Claesson, M. J.,Cusack, S.,Fitzgerald, A. P.,O'Toole, P. W.,Stanton, C.,Ross, R. P. (2012) 'Alterations in intestinal microbiota of elderly Irish subjects post-antibiotic therapy' [Details]
(2012)'Transcriptional and Metabolomic Consequences of luxS Inactivation Reveal a Metabolic Rather than Quorum-Sensing Role for LuxS in Lactobacillus reuteri 100-23'
Wilson, CM,Aggio, RBM,O'Toole, PW,Villas-Boas, S,Tannock, GW (2012) 'Transcriptional and Metabolomic Consequences of luxS Inactivation Reveal a Metabolic Rather than Quorum-Sensing Role for LuxS in Lactobacillus reuteri 100-23' [DOI] [Details]
(2012)'Clostridium difficile Carriage in Elderly Subjects and Associated Changes in the Intestinal Microbiota'
Rea, MC,O'Sullivan, O,Shanahan, F,O'Toole, PW,Stanton, C,Ross, RP,Hill, C (2012) 'Clostridium difficile Carriage in Elderly Subjects and Associated Changes in the Intestinal Microbiota' [DOI] [Details]
(2012)'Gut microbiota composition correlates with diet and health in the elderly'
Claesson, M. J.,Jeffery, I. B.,Conde, S.,Power, S. E.,O'Connor, E. M.,Cusack, S.,Harris, H. M.,Coakley, M.,Lakshminarayanan, B.,O'Sullivan, O.,Fitzgerald, G. F.,Deane, J.,O'Connor, M.,Harnedy, N.,O'Connor, K.,O'Mahony, D.,van Sinderen, D.,Wallace, M.,Brennan, L.,Stanton, C.,Marchesi, J. R.,Fitzgerald, A. P.,Shanahan, F.,Hill, C.,Ross, R. P.,O'Toole, P. W. (2012) 'Gut microbiota composition correlates with diet and health in the elderly' [Details]
(2012)'Fibrinogen-binding and platelet-aggregation activities of a Lactobacillus salivarius septicaemia isolate are mediated by a novel fibrinogen-binding protein'
Collins, J.,van Pijkeren, J. P.,Svensson, L.,Claesson, M. J.,Sturme, M.,Li, Y.,Cooney, J. C.,van Sinderen, D.,Walker, A. W.,Parkhill, J.,Shannon, O.,O'Toole, P. W. (2012) 'Fibrinogen-binding and platelet-aggregation activities of a Lactobacillus salivarius septicaemia isolate are mediated by a novel fibrinogen-binding protein' [Details]
(2012)'Bifidobacterium breve with alpha-Linolenic Acid and Linoleic Acid Alters Fatty Acid Metabolism in the Maternal Separation Model of Irritable Bowel Syndrome'
Barrett, E,Fitzgerald, P,Dinan, TG,Cryan, JF,Ross, RP,Quigley, EM,Shanahan, F,Kiely, B,Fitzgerald, GF,O'Toole, PW,Stanton, C (2012) 'Bifidobacterium breve with alpha-Linolenic Acid and Linoleic Acid Alters Fatty Acid Metabolism in the Maternal Separation Model of Irritable Bowel Syndrome' [DOI] [Details]
(2012)'Structure of ribose 5-phosphate isomerase from the probiotic bacterium Lactobacillus salivarius UCC118'
Lobley, CMC,Aller, P,Douangamath, A,Reddivari, Y,Bumann, M,Bird, LE,Nettleship, JE,Brandao-Neto, J,Owens, RJ,O'Toole, PW,Walsh, MA (2012) 'Structure of ribose 5-phosphate isomerase from the probiotic bacterium Lactobacillus salivarius UCC118' [DOI] [Details]
(2012)'The effect of environmental conditions on expression of Bacteroides fragilis and Bacteroides thetaiotaomicron C10 protease genes'
Thornton, RF,Murphy, EC,Kagawa, TF,O'Toole, PW,Cooney, JC (2012) 'The effect of environmental conditions on expression of Bacteroides fragilis and Bacteroides thetaiotaomicron C10 protease genes' [DOI] [Details]
(2012)'Fibrinogen-binding and platelet-aggregation activities of a Lactobacillus salivarius septicaemia isolate are mediated by a novel fibrinogen-binding protein'
Collins, J,van Pijkeren, JP,Svensson, L,Claesson, MJ,Sturme, M,Li, Y,Cooney, JC,van Sinderen, D,Walker, AW,Parkhill, J,Shannon, O,O'Toole, PW (2012) 'Fibrinogen-binding and platelet-aggregation activities of a Lactobacillus salivarius septicaemia isolate are mediated by a novel fibrinogen-binding protein' [DOI] [Details]
(2012)'Gut microbiota composition correlates with diet and health in the elderly'
Claesson, MJ,Jeffery, IB,Conde, S,Power, SE,O'Connor, EM,Cusack, S,Harris, HMB,Coakley, M,Lakshminarayanan, B,O'Sullivan, O,Fitzgerald, GF,Deane, J,O'Connor, M,Harnedy, N,O'Connor, K,O'Mahony, D,van Sinderen, D,Wallace, M,Brennan, L,Stanton, C,Marchesi, JR,Fitzgerald, AP,Shanahan, F,Hill, C,Ross, RP,O'Toole, PW (2012) 'Gut microbiota composition correlates with diet and health in the elderly' [DOI] [Details]
(2012)'Diet drives gut microbiota variation in the elderly which correlates with health'
Claesson MJ, Jeffery IB, Conde S, Power SE, O’Connor EM, Cusack S, Harris H, Coakley M, Laks B, O’Sullivan O, Fitzgerald G, Deane J, Harnedy N, O’Connor K, O’Mahony D, van Sinderen D, Wallace M, Brennan L, Stanton C, Marchesi JR, Fitzgerald AP, Shanahan F, Hill C, R Ross P, O’Toole PW (2012) 'Diet drives gut microbiota variation in the elderly which correlates with health' [Details]
(2006)'Comparative genomics and transcriptional analysis of prophages identified in the genomes of Lactobacillus gasseri, Lactobacillus salivarius, and Lactobacillus casei'
Ventura M, Canchaya C, Bernini V, Altermann E, Barrangou R, McGrath S, Claesson MJ, Li Y, Leahy S, Walker CD, Zink R, Neviani E, Steele J, Broadbent J, Klaenhammer TR, Fitzgerald GF, O'toole PW, van Sinderen D (2006) 'Comparative genomics and transcriptional analysis of prophages identified in the genomes of Lactobacillus gasseri, Lactobacillus salivarius, and Lactobacillus casei' [DOI] [Details]
(2007)'Bacteriocin production as a mechanism for the antiinfective activity of Lactobacillus salivarius UCC118'
Corr, S.C. and Li, Y. and Riedel, C.U. and O'Toole, P.W. and Hill, C. and Gahan, C.G.M. (2007) 'Bacteriocin production as a mechanism for the antiinfective activity of Lactobacillus salivarius UCC118' [Details]
(2009)'The Bifidobacterium dentium Bd1 genome sequence reflects its genetic adaptation to the human oral cavity'
Ventura M, Turroni F, Zomer A, Foroni E, Giubellini V, Bottacini F, Canchaya C, Claesson MJ, He F, Mantzourani M, Mulas L, Ferrarini A, Gao B, Delledonne M, Henrissat B, Coutinho P, Oggioni M, Gupta RS, Zhang Z, Beighton D, Fitzgerald GF, O'Toole PW, van Sinderen D (2009) 'The Bifidobacterium dentium Bd1 genome sequence reflects its genetic adaptation to the human oral cavity' [DOI] [Details]
(2009)'Genome-scale analyses of health-promoting bacteria: probiogenomics'
Ventura M, O'Flaherty S, Claesson MJ, Turroni F, Klaenhammer TR, van Sinderen D, O'Toole PW (2009) 'Genome-scale analyses of health-promoting bacteria: probiogenomics' [DOI] [Details]
(2010)'Evaluating the latest high-throughput molecular techniques for the exploration of microbial gut communities'
Claesson MJ, O'Toole PW (2010) 'Evaluating the latest high-throughput molecular techniques for the exploration of microbial gut communities' [DOI] [Details]
(2010)'Comparison of two next-generation sequencing technologies for resolving highly complex microbiota composition using tandem variable 16S rRNA gene regions'
Claesson MJ, Wang Q, O'Sullivan O, Greene-Diniz R, Cole JR, Ross RP, O'Toole PW (2010) 'Comparison of two next-generation sequencing technologies for resolving highly complex microbiota composition using tandem variable 16S rRNA gene regions' [DOI] [Details]
(2011)'Composition, variability, and temporal stability of the intestinal microbiota of the elderly'
Claesson, Marcus J. and Cusack, Siobhan and O'Sullivan, Orla and Greene-Diniz, Rachel and de Weerd, Heleen and Flannery, Edel and Marchesi, Julian R. and Falush, Daniel and Dinan, Timothy and Fitzgerald, Gerald and Stanton, Catherine and van Sinderen, Douwe and O'Connor, Michael and Harnedy, Norma and O'Connor, Kieran and Henry, Colm and O'Mahony, Denis and Fitzgerald, Anthony P. and Shanahan, Fergus and Twomey, Cillian and Hill, Colin and Ross, R. Paul and O'Toole, Paul W. (2011) 'Composition, variability, and temporal stability of the intestinal microbiota of the elderly' [Details]
(2011)'Correlation of rRNA gene amplicon pyrosequencing and bacterial culture for microbial compositional analysis of faecal samples from elderly Irish subjects'
O'Sullivan Ó, Coakley M, Lakshminarayanan B, Claesson MJ, Stanton C, O'Toole PW, Ross RP (2011) 'Correlation of rRNA gene amplicon pyrosequencing and bacterial culture for microbial compositional analysis of faecal samples from elderly Irish subjects' [DOI] [Details]
(2011)'Genome sequences and comparative genomics of two Lactobacillus ruminis strains from the bovine and human intestinal tracts'
Forde BM, Neville BA, O'Donnell MM, Riboulet-Bisson E, Claesson MJ, Coghlan A, Ross RP, O'Toole PW (2011) 'Genome sequences and comparative genomics of two Lactobacillus ruminis strains from the bovine and human intestinal tracts' [DOI] [Full Text] [Details]
(2012)'Diversity of Bifidobacteria within the Infant Gut Microbiota'
Turroni F, Peano C, Pass DA, Foroni E, Severgnini M, Claesson MJ, Kerr C, Hourihane J, Murray D, Fuligni F, Gueimonde M, Margolles A, De Bellis G, O'Toole PW, van Sinderen D, Marchesi JR, Ventura M (2012) 'Diversity of Bifidobacteria within the Infant Gut Microbiota' [DOI] [Details]
(2012)'An irritable bowel syndrome subtype defined by species-specific alterations in faecal microbiota'
Jeffery IB, O'Toole PW, Ohman L, Claesson MJ, Deane J, Quigley EM, Simrén M (2012) 'An irritable bowel syndrome subtype defined by species-specific alterations in faecal microbiota' [DOI] [Details]
(2012)'Effect of Lactobacillus salivarius bacteriocin Abp118 on the mouse and pig intestinal microbiota'
Riboulet-Bisson E, Sturme MH, Jeffery IB, O'Donnell MM, Neville BA, Forde BM, Claesson MJ, Harris H, Gardiner GE, Casey PG, Lawlor PG, O'Toole PW, Ross RP (2012) 'Effect of Lactobacillus salivarius bacteriocin Abp118 on the mouse and pig intestinal microbiota' [DOI] [Full Text] [Details]
(2012)'Clostridium difficile Carriage in Elderly Subjects and Associated Changes in the Intestinal Microbiota'
Rea, Mary C. and O'Sullivan, Orla and Shanahan, Fergus and O'Toole, Paul W. and Stanton, Catherine and Ross, R. Paul and Hill, Colin (2012) 'Clostridium difficile Carriage in Elderly Subjects and Associated Changes in the Intestinal Microbiota' [Details]
(2011)'Functional genome analysis of Bifidobacterium breve UCC2003 reveals type IVb tight adherence (Tad) pili as an essential and conserved host-colonization factor'
O'Connell Motherway M, Zomer A, Leahy SC, Reunanen J, Bottacini F, Claesson MJ, O'Brien F, Flynn K, Casey PG, Munoz JA, Kearney B, Houston AM, O'Mahony C, Higgins DG, Shanahan F, Palva A, de Vos WM, Fitzgerald GF, Ventura M, O'Toole PW, van Sinderen D (2011) 'Functional genome analysis of Bifidobacterium breve UCC2003 reveals type IVb tight adherence (Tad) pili as an essential and conserved host-colonization factor' [DOI] [Details]
(2011)'Genomic Diversity of Lactobacillus salivarius'
Raftis, EJ,Salvetti, E,Torriani, S,Felis, GE,O'Toole, PW; (2011) 'Genomic Diversity of Lactobacillus salivarius' [DOI] [Details]
(2010)'The dissemination of C10 cysteine protease genes in Bacteroides fragilis by mobile genetic elements'
Thornton, RF,Kagawa, TF,O'Toole, PW,Cooney, JC; (2010) 'The dissemination of C10 cysteine protease genes in Bacteroides fragilis by mobile genetic elements' [DOI] [Details]
(2010)'Comparative genomics and proteomics of Helicobacter mustelae, an ulcerogenic and carcinogenic gastric pathogen'
O'Toole, PW,Snelling, WJ,Canchaya, C,Forde, BM,Hardie, KR,Josenhans, C,Graham, RLJ,McMullan, G,Parkhill, J,Belda, E,Bentley, SD; (2010) 'Comparative genomics and proteomics of Helicobacter mustelae, an ulcerogenic and carcinogenic gastric pathogen' [DOI] [Full Text] [Details]
(2010)'The human intestinal microbiota, diet and health From infancy to old age'
Cusack, S,O'Toole, PW; (2010) 'The human intestinal microbiota, diet and health From infancy to old age' [Details]
(2010)'Composition and energy harvesting capacity of the gut microbiota: relationship to diet, obesity and time in mouse models'
Murphy, EF,Cotter, PD,Healy, S,Marques, TM,O'Sullivan, O,Fouhy, F,Clarke, SF,O'Toole, PW,Quigley, EM,Stanton, C,Ross, PR,O'Doherty, RM,Shanahan, F; (2010) 'Composition and energy harvesting capacity of the gut microbiota: relationship to diet, obesity and time in mouse models' [DOI] [Details]
(2010)'The 2.2-angstrom Structure of the HP0958 Protein from Helicobacter pylori Reveals a Kinked Anti-Parallel Coiled-Coil Hairpin Domain and a Highly Conserved Zn-Ribbon Domain'
Caly, DL,O'Toole, PW,Moore, SA; (2010) 'The 2.2-angstrom Structure of the HP0958 Protein from Helicobacter pylori Reveals a Kinked Anti-Parallel Coiled-Coil Hairpin Domain and a Highly Conserved Zn-Ribbon Domain' [DOI] [Details]
(2010)'Comparison of two next-generation sequencing technologies for resolving highly complex microbiota composition using tandem variable 16S rRNA gene regions'
Claesson, MJ,Wang, QO,O'Sullivan, O,Greene-Diniz, R,Cole, JR,Ross, RP,O'Toole, PW; (2010) 'Comparison of two next-generation sequencing technologies for resolving highly complex microbiota composition using tandem variable 16S rRNA gene regions' [DOI] [Details]
(2010)'The HP0256 gene product is involved in motility and cell envelope architecture of Helicobacter pylori'
Douillard, FP,Ryan, KA,Lane, MC,Caly, DL,Moore, SA,Penn, CW,Hinds, J,O'Toole, PW; (2010) 'The HP0256 gene product is involved in motility and cell envelope architecture of Helicobacter pylori' [DOI] [Full Text] [Details]
(2009)'Microbial Diversity In The Human Intestine and Novel Insights From Metagenomics'
Ventura, M, Turroni, F, Canchaya, C, Vaughan, EE, O'Toole, PW, van Sinderen, D; (2009) 'Microbial Diversity In The Human Intestine and Novel Insights From Metagenomics' [DOI] [Full Text] [Details]
(2009)'Effect of Flik Mutation On The Transcriptional Activity of The Sigma(54) Sigma Factor Rpon In Helicobacter Pylori'
Douillard, Francois P.; Ryan, Kieran A.; Hinds, Jason; O'Toole, Paul W.; (2009) 'Effect of Flik Mutation On The Transcriptional Activity of The Sigma(54) Sigma Factor Rpon In Helicobacter Pylori' [DOI] [Details]
(2009)'Lactobacillus Salivarius Modulates Cytokine Induction and Virulence Factor Gene Expression In Helicobacter Pylori'
Ryan, Kieran A.; O'Hara, Ann M.; Pijkeren, Jan-Peter van; Douillard, François P.; O'Toole, Paul W.; (2009) 'Lactobacillus Salivarius Modulates Cytokine Induction and Virulence Factor Gene Expression In Helicobacter Pylori' [DOI] [Details]
(2009)'Microbial diversity in the human intestine and novel insights from metagenomics'
Ventura, M,Turroni, F,Canchaya, C,Vaughan, EE,O'Toole, PW,van Sinderen, D; (2009) 'Microbial diversity in the human intestine and novel insights from metagenomics' [DOI] [Details]
(2009)'Effect of FliK mutation on the transcriptional activity of the sigma(54) sigma factor RpoN in Helicobacter pylori'
Douillard, FP,Ryan, KA,Hinds, J,O'Toole, PW; (2009) 'Effect of FliK mutation on the transcriptional activity of the sigma(54) sigma factor RpoN in Helicobacter pylori' [DOI] [Details]
(2009)'Model for Substrate Interactions in C5a Peptidase from Streptococcus pyogenes: A 1.9 angstrom Crystal Structure of the Active Form of ScpA'
Kagawa, TF,O'Connell, MR,Mouat, P,Paoli, M,O'Toole, PW,Cooney, JC; (2009) 'Model for Substrate Interactions in C5a Peptidase from Streptococcus pyogenes: A 1.9 angstrom Crystal Structure of the Active Form of ScpA' [DOI] [Details]
(2009)'Allelic Variation of Bile Salt Hydrolase Genes in Lactobacillus salivarius Does Not Determine Bile Resistance Levels'
Fang, F,Li, Y,Bumann, M,Raftis, EJ,Casey, PG,Cooney, JC,Walsh, MA,O'Toole, PW; (2009) 'Allelic Variation of Bile Salt Hydrolase Genes in Lactobacillus salivarius Does Not Determine Bile Resistance Levels' [DOI] [Details]
(2009)'Lactobacillus salivarius modulates cytokine induction and virulence factor gene expression in Helicobacter pylori'
Ryan, KA,O'Hara, AM,van Pijkeren, JP,Douillard, FP,O'Toole, PW; (2009) 'Lactobacillus salivarius modulates cytokine induction and virulence factor gene expression in Helicobacter pylori' [DOI] [Details]
(2009)'Comparative Analysis of Pyrosequencing and a Phylogenetic Microarray for Exploring Microbial Community Structures in the Human Distal Intestine'
Claesson, MJ,O'Sullivan, O,Wang, Q,Nikkila, J,Marchesi, JR,Smidt, H,de Vos, WM,Ross, RP,O'Toole, PW; (2009) 'Comparative Analysis of Pyrosequencing and a Phylogenetic Microarray for Exploring Microbial Community Structures in the Human Distal Intestine' [DOI] [Details]
(2009)'The Bifidobacterium dentium Bd1 Genome Sequence Reflects Its Genetic Adaptation to the Human Oral Cavity'
Ventura, Marco; Turroni, Francesca; Zomer, Aldert; Foroni, Elena; Giubellini, Vanessa; Bottacini, Francesca; Canchaya, Carlos; Claesson, Marcus J; He, Fei; Mantzourani, Maria; Mulas, Laura; Ferrarini, Alberto; Gao, Beile; Delledonne, Massimo; Henrissat, Bernard; Coutinho, Pedro; Oggioni, Marco; Gupta, Radhey S; Zhang, Ziding; Beighton, David; Fitzgerald, Gerald F; O'Toole, Paul W; van Sinderen, Douwe; (2009) 'The Bifidobacterium dentium Bd1 Genome Sequence Reflects Its Genetic Adaptation to the Human Oral Cavity' [DOI] [Details]
(2009)'Model For Substrate Interactions In C5a Peptidase From Streptococcus Pyogenes: A 1.9 Angstrom Crystal Structure of The Active Form of Scpa'
Kagawa, TF, O'Connell, MR, Mouat, P, Paoli, M, O'Toole, PW, Cooney, JC; (2009) 'Model For Substrate Interactions In C5a Peptidase From Streptococcus Pyogenes: A 1.9 Angstrom Crystal Structure of The Active Form of Scpa' [DOI] [Details]
(2009)'Comparative analysis of pyrosequencing and a phylogenetic microarray for exploring microbial community structures in the human distal intestine'
Claesson MJ, O'Sullivan O, Wang Q, Nikkil� J, Marchesi JR, Smidt H, de Vos WM, Ross RP, O'Toole PW; (2009) 'Comparative analysis of pyrosequencing and a phylogenetic microarray for exploring microbial community structures in the human distal intestine' [DOI] [Details]
(2009)'Microbial diversity in the human intestine: benefits of a metagenomics approach'
Ventura, M., Turroni, F., Canchaya, C., Vaughan, E., O¿Toole, P.W. and D. van Sinderen. ; (2009) 'Microbial diversity in the human intestine: benefits of a metagenomics approach' [Details]
(2009)'Allelic Variation of Bile Salt Hydrolase Genes In Lactobacillus Salivarius Does Not Determine Bile Resistance Levels'
Fang, F, Li, Y, Bumann, M, Raftis, EJ, Casey, PG, Cooney, JC, Walsh, MA, O'Toole, PW; (2009) 'Allelic Variation of Bile Salt Hydrolase Genes In Lactobacillus Salivarius Does Not Determine Bile Resistance Levels' [DOI] [Details]
(2008)'Isolation of Lactobacilli With Probiotic Properties From The Human Stomach'
Ryan, KA, Jayaraman, T, Daly, P, Canchaya, C, Curran, S, Fang, F, Quigley, EM, O'Toole, PW; (2008) 'Isolation of Lactobacilli With Probiotic Properties From The Human Stomach' [DOI] [Full Text] [Details]
(2008)'Isolation of lactobacilli with probiotic properties from the human stomach. Lett Appl Microbiol'
Ryan, K. A.,Jayaraman, T.,Daly, P.,Canchaya, C.,Curran, S.,Fang, F.,Quigley, E. M.,O'Toole, P. W.; (2008) 'Isolation of lactobacilli with probiotic properties from the human stomach. Lett Appl Microbiol' [Details]
(2008)'Strain-Specific Inhibition of Helicobacter Pylori By Lactobacillus Salivarius and Other Lactobacilli'
Ryan, KA, Daly, P, Li, Y, Hooton, C, O'Toole, PW; (2008) 'Strain-Specific Inhibition of Helicobacter Pylori By Lactobacillus Salivarius and Other Lactobacilli' [DOI] [Details]
(2008)'Lactobacillus phylogenomics--towards a reclassification of the genus'
Claesson MJ, van Sinderen D, O'Toole PW; (2008) 'Lactobacillus phylogenomics--towards a reclassification of the genus' [DOI] [Details]
(2008)'Strain-specific inhibition of Helicobacter pylori by Lactobacillus salivarius and other lactobacilli'
Ryan, KA,Daly, P,Li, Y,Hooton, C,O'Toole, PW; (2008) 'Strain-specific inhibition of Helicobacter pylori by Lactobacillus salivarius and other lactobacilli' [DOI] [Details]
(2008)'Characterization of endogenous plasmids from Lactobacillus salivarius UCC118'
Fang, F,Flynn, S,Li, Y,Claesson, MJ,van Pijkeren, JP,Collins, JK,van Sinderen, D,O'Toole, PW; (2008) 'Characterization of endogenous plasmids from Lactobacillus salivarius UCC118' [DOI] [Details]
(2008)'Isolation of lactobacilli with probiotic properties from the human stomach'
Ryan, KA,Jayaraman, T,Daly, P,Canchaya, C,Curran, S,Fang, F,Quigley, EM,O'Toole, PW; (2008) 'Isolation of lactobacilli with probiotic properties from the human stomach' [DOI] [Details]
(2008)'Lactobacillus phylogenomics - towards a reclassification of the genus'
Claesson, MJ,van Sinderen, D,O'Toole, PW; (2008) 'Lactobacillus phylogenomics - towards a reclassification of the genus' [DOI] [Details]
(2008)'Posttranscriptional Regulation of Flagellin Synthesis in Helicobacter pylori by the RpoN Chaperone HP0958'
Douillard, FP,Ryan, KA,Caly, DL,Hinds, J,Witney, AA,IIusain, SE,O'Toole, PW; (2008) 'Posttranscriptional Regulation of Flagellin Synthesis in Helicobacter pylori by the RpoN Chaperone HP0958' [DOI] [Details]
(2008)'Characterization of endogenous plasmids from Lactobacillus salivarius UCC118'
Fang F, Flynn S, Li Y, Claesson MJ, van Pijkeren JP, Collins JK, van Sinderen D, O'Toole PW; (2008) 'Characterization of endogenous plasmids from Lactobacillus salivarius UCC118' [DOI] [Details]
(2008)'Lactobacillus Phylogenomics - Towards A Reclassification of The Genus'
Claesson, MJ, van Sinderen, D, O'Toole, PW; (2008) 'Lactobacillus Phylogenomics - Towards A Reclassification of The Genus' [DOI] [Details]
(2008)'Posttranscriptional Regulation of Flagellin Synthesis In Helicobacter Pylori By The Rpon Chaperone Hp0958'
Douillard, FP, Ryan, KA, Caly, DL, Hinds, J, Witney, AA, IIusain, SE, O'Toole, PW; (2008) 'Posttranscriptional Regulation of Flagellin Synthesis In Helicobacter Pylori By The Rpon Chaperone Hp0958' [DOI] [Details]
(2008)'Characterization of Endogenous Plasmids From Lactobacillus Salivarius Ucc118'
Fang, F, Flynn, S, Li, Y, Claesson, MJ, van Pijkeren, JP, Collins, JK, van Sinderen, D, O'Toole, PW; (2008) 'Characterization of Endogenous Plasmids From Lactobacillus Salivarius Ucc118' [DOI] [Details]
(2007)'Bacteriocin production as a mechanism for the antiinfective activity of Lactobacillus salivarius UCC118'
Corr SC, Li Y, Riedel CU, O'Toole PW, Hill C, Gahan CG; (2007) 'Bacteriocin production as a mechanism for the antiinfective activity of Lactobacillus salivarius UCC118' [DOI] [Details]
(2007)'Bacteriocin Production As A Mechanism For The Antfinfective Activity of Lactobacillus Salivarius Ucc118'
Corr, SC, Li, Y, Riedel, CU, O'Toole, PW, Hill, C, Gahan, CGM; (2007) 'Bacteriocin Production As A Mechanism For The Antfinfective Activity of Lactobacillus Salivarius Ucc118' [DOI] [Details]
(2007)'Horb (Hp0127) Is A Gastric Epithelial Cell Adhesin'
Snelling, WJ, Moran, AP, Ryan, KA, Scully, P, McGourty, K, Cooney, JC, Annuk, H, O'Toole, PW; (2007) 'Horb (Hp0127) Is A Gastric Epithelial Cell Adhesin' [Details]
(2007)'Distribution of Megaplasmids In Lactobacillus Salivarius and Other Lactobacilli'
Li, Y, Canchaya, C, Fang, F, Raftis, E, Ryan, KA, van Pijkeren, JP, van Sinderen, D, O'Toole, PW; (2007) 'Distribution of Megaplasmids In Lactobacillus Salivarius and Other Lactobacilli' [DOI] [Details]
(2007)'The Genus Lactobacillus - A Genomic Basis For Understanding Its Diversity'
Claesson, MJ, van Sinderen, D, O'Toole, PW; (2007) 'The Genus Lactobacillus - A Genomic Basis For Understanding Its Diversity' [DOI] [Details]
(2007)'The genus Lactobacillus - a genomic basis for understanding its diversity'
Claesson, MJ,van Sinderen, D,O'Toole, PW; (2007) 'The genus Lactobacillus - a genomic basis for understanding its diversity' [DOI] [Details]
(2007)'HorB (HP0127) is a gastric epithelial cell adhesin'
Snelling, WJ,Moran, AP,Ryan, KA,Scully, P,McGourty, K,Cooney, JC,Annuk, H,O'Toole, PW; (2007) 'HorB (HP0127) is a gastric epithelial cell adhesin' [Details]
(2007)'Bacteriocin production as a mechanism for the antfinfective activity of Lactobacillus salivarius UCC118'
Corr, SC,Li, Y,Riedel, CU,O'Toole, PW,Hill, C,Gahan, CGM; (2007) 'Bacteriocin production as a mechanism for the antfinfective activity of Lactobacillus salivarius UCC118' [DOI] [Details]
(2007)'Distribution of megaplasmids in Lactobacillus salivarius and other Lactobacilli'
Li, Y,Canchaya, C,Fang, F,Raftis, E,Ryan, KA,van Pijkeren, JP,van Sinderen, D,O'Toole, PW; (2007) 'Distribution of megaplasmids in Lactobacillus salivarius and other Lactobacilli' [DOI] [Details]
(2007)'The genus Lactobacillus--a genomic basis for understanding its diversity'
Claesson MJ, van Sinderen D, O'Toole PW; (2007) 'The genus Lactobacillus--a genomic basis for understanding its diversity' [DOI] [Details]
(2007)'Distribution of megaplasmids in Lactobacillus salivarius and other lactobacilli'
Ryan KA, van Pijkeren JP, van Sinderen D, O'Toole PW, Li Y, Canchaya C, Fang F, Raftis E; (2007) 'Distribution of megaplasmids in Lactobacillus salivarius and other lactobacilli' [DOI] [Details]
(2007)'(From the cover) Bacteriocin production as a mechanism for the anti-infective activity of Lactobacillus salivarius UCC118'
Corr SC, Li Y, Riedel CU, O’Toole PW, Hill C and Gahan CGM; (2007) '(From the cover) Bacteriocin production as a mechanism for the anti-infective activity of Lactobacillus salivarius UCC118' [Details]
(2006)'Diversity of the genus Lactobacillus revealed by comparative genomics of five species'
Canchaya, C. Claesson, M.J. Fitzgerald, G.F. van Sinderen, D. O'Toole, P.W.; (2006) 'Diversity of the genus Lactobacillus revealed by comparative genomics of five species' [Details]
(2006)'Genomics and transcriptional analysis of prophages identified in the genomes of Lactobacillus gasseri, Lactobacillus salivarius and Lactobacillus casei'
Ventura, M. Canchaya, C. Bernini, V. Altermann, E. Barrangou, R. McGrath, S. Claesson, M. Li, Y. Leahy, S. Walker, C.D. Zink, R. Neviani, E. Steele, J. Broadbent, J. Klaenhammer, T.R. Fitzgerald, F.F. O'Toole, P.W. van Sinderen, D.; (2006) 'Genomics and transcriptional analysis of prophages identified in the genomes of Lactobacillus gasseri, Lactobacillus salivarius and Lactobacillus casei' [Details]
(2006)'Diversity of the genus Lactobacillus revealed by comparative genomics of five species'
Canchaya, C,Claesson, MJ,Fitzgerald, GF,van Sinderen, D,O'Toole, PW; (2006) 'Diversity of the genus Lactobacillus revealed by comparative genomics of five species' [DOI] [Details]
(2006)'Diversity of The Genus Lactobacillus Revealed By Comparative Genomics of Five Species'
Canchaya, C, Claesson, MJ, Fitzgerald, GF, van Sinderen, D, O'Toole, PW; (2006) 'Diversity of The Genus Lactobacillus Revealed By Comparative Genomics of Five Species' [DOI] [Details]
(2006)'Molecular basis of the interaction between the flagellar export proteins FliI and FliH from Helicobacter pylori'
Lane, M.C. O’Toole, P.W. Moore, S.A.; (2006) 'Molecular basis of the interaction between the flagellar export proteins FliI and FliH from Helicobacter pylori' [Details]
(2006)'Comparative genomics and transcriptional analysis of prophages identified in the Genomes of Lactobacillus gasseri, Lactobacillus salivarius, and Lactobacillus casei'
Ventura, M,Canchaya, C,Bernini, V,Altermann, E,Barrangou, R,McGrath, S,Claesson, MJ,Li, Y,Leahy, S,Walker, CD,Zink, R,Neviani, E,Steele, J,Broadbent, J,Klaenhammer, TR,Fitzgerald, GF,O'Toole, PW,van Sinderen, D; (2006) 'Comparative genomics and transcriptional analysis of prophages identified in the Genomes of Lactobacillus gasseri, Lactobacillus salivarius, and Lactobacillus casei' [DOI] [Details]
(2006)'Molecular basis of the interaction between the flagellar export proteins FliI and FliH from Helicobacter pylori'
Lane, MC,O'Toole, PW,Moore, SA; (2006) 'Molecular basis of the interaction between the flagellar export proteins FliI and FliH from Helicobacter pylori' [DOI] [Details]
(2006)'Multireplicon genome architecture of Lactobacillus salivarius'
Claesson, MJ,Li, Y,Leahy, S,Canchaya, C,van Pijkeren, JP,Cerdeno-Tarraga, AM,Parkhill, J,Flynn, S,O'Sullivan, GC,Collins, JK,Higgins, D,Shanahan, F,Fitzgerald, GF,van Sinderen, D,O'Toole, PW; (2006) 'Multireplicon genome architecture of Lactobacillus salivarius' [DOI] [Details]
(2006)'Comparative and functional analysis of sortase-dependent proteins in the predicted secretome of Lactobacillus salivarius UCC118'
van Pijkeren, JP,Canchaya, C,Ryan, KA,Li, Y,Claesson, MJ,Sheil, B,Steidler, L,O'Mahony, L,Fitzgerald, GF,van Sinderen, D,O'Toole, PW; (2006) 'Comparative and functional analysis of sortase-dependent proteins in the predicted secretome of Lactobacillus salivarius UCC118' [DOI] [Details]
(2006)'Polyphasic analysis indicates that Lactobacillus salivarius subsp salivarius and Lactobacillus salivarius subsp salicinius do not merit separate subspecies status'
Li, Y,Raftis, E,Canchaya, C,Fitzgerald, GF,van Sinderen, D,O'Toole, PW; (2006) 'Polyphasic analysis indicates that Lactobacillus salivarius subsp salivarius and Lactobacillus salivarius subsp salicinius do not merit separate subspecies status' [DOI] [Details]
(2006)'Multireplicon genome architecture of Lactobacillus salivarius'
Claesson MJ, Li Y, Leahy S, Canchaya C, van Pijkeren JP, Cerde�o-T�rraga AM, Parkhill J, Flynn S, O'Sullivan GC, Collins JK, Higgins D, Shanahan F, Fitzgerald GF, van Sinderen D, O'Toole PW; (2006) 'Multireplicon genome architecture of Lactobacillus salivarius' [DOI] [Details]
(2006)'Comparative and functional analysis of sortase-dependent proteins in the predicted secretome of Lactobacillus salivarius UCC118'
van Pijkeren JP, Canchaya C, Ryan KA, Li Y, Claesson MJ, Sheil B, Steidler L, O'Mahony L, Fitzgerald GF, van Sinderen D, O'Toole PW; (2006) 'Comparative and functional analysis of sortase-dependent proteins in the predicted secretome of Lactobacillus salivarius UCC118' [DOI] [Details]
(2006)'Polyphasic analysis indicates that Lactobacillus salivarius subsp. salivarius and Lactobacillus salivarius subsp. salicinius do not merit separate subspecies status'
Li Y, Raftis E, Canchaya C, Fitzgerald GF, van Sinderen D, O'Toole PW; (2006) 'Polyphasic analysis indicates that Lactobacillus salivarius subsp. salivarius and Lactobacillus salivarius subsp. salicinius do not merit separate subspecies status' [DOI] [Details]
(2006)'Diversity of the genus Lactobacillus revealed by comparative genomics of five species'
Canchaya C, Claesson MJ, Fitzgerald GF, van Sinderen D, O'Toole PW; (2006) 'Diversity of the genus Lactobacillus revealed by comparative genomics of five species' [DOI] [Details]
(2006)'Polyphasic analysis indicates that Lactobacillus salivarius subsp. salivarius and Lactobacillus salivarius subsp. salicinius do not merit separate subspecies status'
Li, Y. Raftis, E. Canchaya, C. Fitzgerald, G.F. van Sinderen, D. O’Toole, P.W.; (2006) 'Polyphasic analysis indicates that Lactobacillus salivarius subsp. salivarius and Lactobacillus salivarius subsp. salicinius do not merit separate subspecies status' [Details]
(2006)'Comparative and functional analysis of sortase-dependent proteins in the predicted secretome of Lactobacillus salivarius UCC118'
Van Pijkeren, J-P. Canchaya, C. Ryan, K.A. Li, Y. Claesson, M.J. Sheil, B. Steidler, L. O’Mahony, L. Fitzgerald, G.F. van Sinderen, D. O’Toole, P.W.; (2006) 'Comparative and functional analysis of sortase-dependent proteins in the predicted secretome of Lactobacillus salivarius UCC118' [Details]
(2006)'Comparative and functional analysis of sortase-dependent proteins in the predicted secretome of Lactobacillus salivarius UCC118'
Van Pijkeren, J-P., C. Canchaya, K. A. Ryan, Y. Li, M. J. Claesson, B. Sheil, L. Steidler, L. O¿Mahony, G. F. Fitzgerald, D. van Sinderen and P. W. O¿Toole. ; (2006) 'Comparative and functional analysis of sortase-dependent proteins in the predicted secretome of Lactobacillus salivarius UCC118' [Details]
(2006)'Molecular basis of the interaction between the flagellar export proteins FliI and FliH from Helicobacter pylori'
Lane, M.C., P.W. O¿Toole, and S.A. Moore. ; (2006) 'Molecular basis of the interaction between the flagellar export proteins FliI and FliH from Helicobacter pylori' [Details]
(2006)'Polyphasic Analysis Indicates That Lactobacillus Salivarius Subsp Salivarius and Lactobacillus Salivarius Subsp Salicinius Do Not Merit Separate Subspecies Status'
Li, Y, Raftis, E, Canchaya, C, Fitzgerald, GF, van Sinderen, D, O'Toole, PW; (2006) 'Polyphasic Analysis Indicates That Lactobacillus Salivarius Subsp Salivarius and Lactobacillus Salivarius Subsp Salicinius Do Not Merit Separate Subspecies Status' [DOI] [Details]
(2006)'Multi-replicon genome architecture of Lactobacillus salivarius'
Claesson, M.J. Li, Y. Leahy, S. Canchaya, C. van Pijkeren, J-P. Cerdeño-Tárraga, A.M. Parkhill, J. Flynn, S. O’Sullivan, G.C. Collins, J.K. Higgins, D. Shanahan, F. Fitzgerald, G.F. van Sinderen D. O'Toole, P.W.; (2006) 'Multi-replicon genome architecture of Lactobacillus salivarius' [Details]
(2006)'Multi-replicon genome architecture of Lactobacillus salivarius'
Claesson, M.J. Li, Y. Leahy, S. Canchaya, C. van Pijkeren, J-P. Cerdeño-Tárraga, A.M. Parkhill, J. Flynn, S. O’Sullivan, G.C. Collins, J.K. Higgins, D. Shanahan, F. Fitzgerald, G.F. van Sinderen D. O'Toole, P.W.; (2006) 'Multi-replicon genome architecture of Lactobacillus salivarius' [Details]
(2005)'HP0958 is an essential motility gene in Helicobacter pylori'
Ryan, K. A. Karim, Q.N. Worku, M. Moore, S.A. Penn, C.W. O'Toole, P.W.; (2005) 'HP0958 is an essential motility gene in Helicobacter pylori' [Details]
(2005)'HP0958 is an essential motility gene in Helicobacter pylori'
Ryan, KA,Karim, N,Worku, M,Moore, SA,Penn, CW,O'Toole, PW; (2005) 'HP0958 is an essential motility gene in Helicobacter pylori' [DOI] [Details]
(2005)'Helicobacter pylori flagellar hook-filament transition is controlled by a FliK functional homolog encoded by the gene HP0906'
Ryan, KA,Karim, N,Worku, M,Penn, CW,O'Toole, PW; (2005) 'Helicobacter pylori flagellar hook-filament transition is controlled by a FliK functional homolog encoded by the gene HP0906' [DOI] [Details]
(2005)'SpeB-Spi: a novel protease-inhibitor pair from Streptococcus pyogenes'
Kagawa, TF,O'Toole, PW,Cooney, JC; (2005) 'SpeB-Spi: a novel protease-inhibitor pair from Streptococcus pyogenes' [DOI] [Details]
(2005)'Helicobacter pylori flagellar hook-filament transition is controlled by a FliK functional homolog encoded by the gene HP0906'
Ryan, K.A Karim, Q.N. Worku, M. Penn, C.W. O’Toole, P.W.; (2005) 'Helicobacter pylori flagellar hook-filament transition is controlled by a FliK functional homolog encoded by the gene HP0906' [Details]
(2005)'SpeB-Spi: a novel protease-inhibitor pair from Streptococcus pyogenes'
Kagawa, T.F. O’Toole, P.W. Cooney, J.C.; (2005) 'SpeB-Spi: a novel protease-inhibitor pair from Streptococcus pyogenes' [Details]
(2005)'Helicobacter pylori flagellar hook-filament transition is controlled by a FliK functional homolog encoded by the gene HP0906'
Ryan, K.A, Karim, Q.N., Worku, M., Penn, C.W. and P.W. O¿Toole; (2005) 'Helicobacter pylori flagellar hook-filament transition is controlled by a FliK functional homolog encoded by the gene HP0906' [Details]
(2005)'SpeB-Spi: a novel protease-inhibitor pair from Streptococcus pyogenes'
Kagawa, T.F., P.W. O¿Toole, and J.C. Cooney; (2005) 'SpeB-Spi: a novel protease-inhibitor pair from Streptococcus pyogenes' [Details]
(2005)'Isolation of lactococcal prolate phage-phage recombinants by an enrichment strategy reveals two novel host range determinants'
Rakonjac, J. O'Toole, P.W. Lubbers, M.; (2005) 'Isolation of lactococcal prolate phage-phage recombinants by an enrichment strategy reveals two novel host range determinants' [Details]
(2004)'Essentiality of the early transcript in the replication origin of the lactococcal prolate phage c2'
Schiemann, A., Rakonjac, M., Callanan, J., Gordon, K., Polzin, K., Lubbers, NW., O'Toole, PW; (2004) 'Essentiality of the early transcript in the replication origin of the lactococcal prolate phage c2' [Details]
(2004)'Novel chromosomally encoded multidrug efflux transporter MdeA in Staphylococcus aureus'
Huang, J., O'Toole, P.W., Shen, W., Madsen, .A., Jiang, X., Lobo, N., Palmer, L.M., Voelker, L., Fan, F., Gwynn, M., and D. McDevitt. ; (2004) 'Novel chromosomally encoded multidrug efflux transporter MdeA in Staphylococcus aureus' [Details]
(2004)'Essentiality of the early transcript in the replication origin of the lactococcal prolate phage c2'
Schiemann, AH,Rakonjac, J,Callanan, M,Gordon, J,Polzin, K,Lubbers, MW,O'Toole, PW; (2004) 'Essentiality of the early transcript in the replication origin of the lactococcal prolate phage c2' [DOI] [Details]
(2003)'Detection and isolation of helicobacter mustelae from stoats in New Zealand'
Forester, NT., Lumsden, K., Parton, P., Cowan, P., O'Toole, PW.; (2003) 'Detection and isolation of helicobacter mustelae from stoats in New Zealand' [Details]
(2003)'Sequence diversity and functional conservation of the origin of replication in lactococcal prolate phages'
Rakonjac, J., Ward, L., Schiemann, A., Gardner, P., Lubbers, M., O'Toole, PW.; (2003) 'Sequence diversity and functional conservation of the origin of replication in lactococcal prolate phages' [Details]
(2003)'Failure of surface ring-mutant strains of helicobacter mustelae to persistently infect the ferret stomach'
Patterson, M., O'Toole, PW., Forrester, NT., Noonan, B., Trust, TJ., XU, S., Taylor, NS., Marini, Ihrig, M., Fox, JG.; (2003) 'Failure of surface ring-mutant strains of helicobacter mustelae to persistently infect the ferret stomach' [Details]
(2002)'Novel chromosomally encoded multidrug efflux transporter MdeA in Staphylococcus aureus'
Huang, J. O'Toole, P.W. Shen, W. Madsen, A. Jiang, X. Lobo, N. Palmer, L. Voelker, L. Fan, F. Gwynn, M. McDevitt, D.; (2002) 'Novel chromosomally encoded multidrug efflux transporter MdeA in Staphylococcus aureus' [Details]
(2002)'Cloning and expression of an oligopeptidase, Pep O, with novel specificity from Lactobacillus rhamnosus HN001 (DR20TM)'
Christensson, C. Bratt, H. Collins, L. Coolbear, T. Holland, R. Lubbers, M.W. O’Toole, P.W. Reid, J.R.; (2002) 'Cloning and expression of an oligopeptidase, Pep O, with novel specificity from Lactobacillus rhamnosus HN001 (DR20TM)' [Details]
(2002)'. Cloning and expression of an oligopeptidase, Pep O, with novel specificity from Lactobacillus rhamnosus HN001 (DR20TM)'
Christensson, C., H. Bratt, L. Collins, T. Coolbear, R. Holland, M. W. Lubbers, P. W. O¿Toole, and J. R. Reid. ; (2002) '. Cloning and expression of an oligopeptidase, Pep O, with novel specificity from Lactobacillus rhamnosus HN001 (DR20TM)' [Details]
(2002)'Phenotypic variation of Helicobacter pylori isolates from geographically distinct regions detected by lectin typing'
Hynes, SO., Broutet, N., Wadstrom, T., Mikelsaar, M., O'Toole, PW., Telford, J., Engstrand, L., Kamiya, S., Mentis, AF., Moran, AP; (2002) 'Phenotypic variation of Helicobacter pylori isolates from geographically distinct regions detected by lectin typing' [Details]
(2001)'Examination of lactococcal bacteriophage c2 DNA replication using two-dimensional agarose gel electrophoresis'
Callanan, M.J., O'Toole, P.W. Lubbers, M.W. Polzin, K.M.; (2001) 'Examination of lactococcal bacteriophage c2 DNA replication using two-dimensional agarose gel electrophoresis' [Details]
(2001)'Identification of Yersinia-infected blood donors by anti-Yop IgA immunoassay'
Kendrick, C.J. Morriss, A.J. O’Toole, P.W.; (2001) 'Identification of Yersinia-infected blood donors by anti-Yop IgA immunoassay' [Details]
(2001)'Nucleotide sequence and characterisation of the cell envelope proteinase plasmid in Lactococcus lactis subsp. cremoris HP'
Christensson, C., Pillidge, C.J. Ward, L.J.H. O’Toole, P.W.; (2001) 'Nucleotide sequence and characterisation of the cell envelope proteinase plasmid in Lactococcus lactis subsp. cremoris HP' [Details]
(2001)'Sequence and antigenic variability of the Helicobacter mustelae surface ring protein Hsr'
Forester, N.T., Lumsden, J.S. O'Croinín, T. O’Toole, P.W.; (2001) 'Sequence and antigenic variability of the Helicobacter mustelae surface ring protein Hsr' [Details]
(2007)'The genus Lactobacillus - a genomic basis for understanding its diversity'
Claesson, M.J., van Sinderen, D., and P.W. O'Toole. ; (2007) 'The genus Lactobacillus - a genomic basis for understanding its diversity' [Details]
(2001)'Identification of Yersinia-infected blood donors by anti-Yop IgA immunoassay'
Kendrick, C.J., B. Baker, A.J. Morriss & P.W. O¿Toole. ; (2001) 'Identification of Yersinia-infected blood donors by anti-Yop IgA immunoassay' [Details]
(2001)'Nucleotide sequence and characterisation of the cell envelope proteinase plasmid in Lactococcus lactis subsp. cremoris'
Christensson, C., C.J. Pillidge, L.J.H. Ward and P.W. O¿Toole; (2001) 'Nucleotide sequence and characterisation of the cell envelope proteinase plasmid in Lactococcus lactis subsp. cremoris' [Details]
(2001)'Sequence and antigenic variability of the Helicobacter mustelae surface ring protein'
Forester, N.T., Lumsden, J.S., T. O'Croinín, and P.W. O¿Toole. ; (2001) 'Sequence and antigenic variability of the Helicobacter mustelae surface ring protein' [Details]
(2000)'Isolation of Helicobacter mustelae from ferrets in New Zealand'
Forester, N.T. Parton, K. Lumsden, J.S. O'Toole, P.W.; (2000) 'Isolation of Helicobacter mustelae from ferrets in New Zealand' [Details]
(2000)'Helicobacter pylori motility'
O¿Toole, P.W., M. Lane and S. Porwollik. ; (2000) 'Helicobacter pylori motility' [Details]
(2000)'Helicobacter pylori motility'
O’Toole, P.W. M. Lane S. Porwollik.; (2000) 'Helicobacter pylori motility' [Details]
(1999)'Molecular characterization of a flagellar export locus of Helicobacter pylori'
Porwollik, P., B. Noonan, and P.W. O¿Toole. ; (1999) 'Molecular characterization of a flagellar export locus of Helicobacter pylori' [Details]
(1999)'Potentiation of methicillin activity against methicillin-resistant Staphylococcus aureus by diterpenes'
Nicolson, K. Evans, G. O’Toole, P.W.; (1999) 'Potentiation of methicillin activity against methicillin-resistant Staphylococcus aureus by diterpenes' [Details]
(1999)'Potentiation of methicillin activity against methicillin-resistant Staphylococcus aureus by diterpenes'
Nicolson, K., G. Evans, and P.W. O¿Toole. ; (1999) 'Potentiation of methicillin activity against methicillin-resistant Staphylococcus aureus by diterpenes' [Details]
(1999)'Molecular characterization of a flagellar export locus of Helicobacter pylori'
Porwollik, P. Noonan, B. O’Toole, P.W.; (1999) 'Molecular characterization of a flagellar export locus of Helicobacter pylori' [Details]
(1997)'Evidence for ethnic tropism of Helicobacter pylori'
Campbell, S., B. Holliss, A.G. Fraser, J. Schmid & P.W. O¿Toole. ; (1997) 'Evidence for ethnic tropism of Helicobacter pylori' [Details]
(1997)'Evidence for ethnic tropism of Helicobacter pylori'
Campbell, S. Holliss, B. Fraser, A.G. Schmid, J. O’Toole, P.W.; (1997) 'Evidence for ethnic tropism of Helicobacter pylori' [Details]
(1995)'Stimulation of interleukin-8 production in cultured epithelial cells by Helicobacter pylori'
Huang, J. O'Toole, P.W. Doig, P. Trust, T.J.; (1995) 'Stimulation of interleukin-8 production in cultured epithelial cells by Helicobacter pylori' [Details]
(1995)'The putative neuraminyllactose-binding hemagglutinin HpaA of Helicobacter pylori CCUG 17874 is a lipoprotein'
O'Toole, P.W. Janzon, L. Doig, P. Huang, J. Kostrzynska, M. Trust, T.J.; (1995) 'The putative neuraminyllactose-binding hemagglutinin HpaA of Helicobacter pylori CCUG 17874 is a lipoprotein' [Details]
(1995)'The complex flagella of gastric Helicobacter species'
O¿Toole, P.W. and T.J. Trust. ; (1995) 'The complex flagella of gastric Helicobacter species' [Details]
(1994)'Identification and molecular characterization of a major ring-forming surface protein of the gastric pathogen Helicobacter mustelae'
O'Toole, P.W. Austin, J.W. Trust, T.J.; (1994) 'Identification and molecular characterization of a major ring-forming surface protein of the gastric pathogen Helicobacter mustelae' [Details]
(1994)'Non-motile mutants of Helicobacter pylori and Helicobacter mustelae defective in flagellar hook production'
O'Toole, P.W. Kostrzynska, M. Trust, T.J.; (1994) 'Non-motile mutants of Helicobacter pylori and Helicobacter mustelae defective in flagellar hook production' [Details]
(1994)'Identification and molecular characterization of a conserved lipoprotein of the gastric pathogen Helicobacter pylori'
Kostrzynska, M. O'Toole, P.W. Trust, T.J.; (1994) 'Identification and molecular characterization of a conserved lipoprotein of the gastric pathogen Helicobacter pylori' [Details]
(1994)'Molecular characterization of protein Sir, a streptococcal cell surface protein that binds both Immunoglobulin A and Immunoglobulin G'
Stenberg, L. O'Toole, P.W. Mestecky, J. Lindahl, G.; (1994) 'Molecular characterization of protein Sir, a streptococcal cell surface protein that binds both Immunoglobulin A and Immunoglobulin G' [Details]
(1993)'The gamma hemolysin locus of Staphylococcus aureus comprises three linked genes, two of which are identical to the genes for the F and S components of leukocidin'
Cooney, J. Foster, T.J. O'Toole, P.W.; (1993) 'The gamma hemolysin locus of Staphylococcus aureus comprises three linked genes, two of which are identical to the genes for the F and S components of leukocidin' [Details]
(1992)'Adhesive properties conferred by the plasminogen activator of Yersinia pestis'
Kienle, Z. Emödy, L. Swanborg, C. O'Toole, P.W.; (1992) 'Adhesive properties conferred by the plasminogen activator of Yersinia pestis' [Details]
(1992)'Rapid detection of Helicobacter pylori in gastric biopsy material by the polymerase chain reaction'
Hammar, M., Tyszkievicz, T. Wadström T. O'Toole, P.W.; (1992) 'Rapid detection of Helicobacter pylori in gastric biopsy material by the polymerase chain reaction' [Details]
(1992)'Many group A streptococcal strains express two different immunoglobulin-binding proteins, encoded by closely linked genes: characterization of the proteins expressed by four strains of different M-type'
Stenberg, L., P. O'Toole and G. Lindahl. ; (1992) 'Many group A streptococcal strains express two different immunoglobulin-binding proteins, encoded by closely linked genes: characterization of the proteins expressed by four strains of different M-type' [Details]
(1992)'Two major classes in the M protein family in group A streptococci'
O'Toole, P.W., Stenberg, L. Rissler, M. Lindahl, G.; (1992) 'Two major classes in the M protein family in group A streptococci' [Details]
(1991)'Isolation, biochemical and molecular analyses of a species-specific protein antigen from the gastric pathogen Helicobacter pylori'
O'Toole, P.W. Logan, S. Kostrzynska, M. Wadström T. Trust, T.J.; (1991) 'Isolation, biochemical and molecular analyses of a species-specific protein antigen from the gastric pathogen Helicobacter pylori' [Details]
(1991)'High affinity binding of the basement membrane proteins collagen type IV and laminin to the gastric pathogen Helicobacter pylori'
Trust, T.J., P. Doig, L. Emödy, Z. Kienle, T. Wadström and P. O'Toole. ; (1991) 'High affinity binding of the basement membrane proteins collagen type IV and laminin to the gastric pathogen Helicobacter pylori' [Details]
(1989)'Binding to collagen by Yersinia enterocolitica and Yersinia pseudotuberculosis: Evidence for YOPA-mediated and chromosomally encoded mechanisms'
Emödy, L., Heesemann, J. Wolf-Watz, H. Skurnik, M Kapperud, G. O'Toole, P.W. Wadström, T.; (1989) 'Binding to collagen by Yersinia enterocolitica and Yersinia pseudotuberculosis: Evidence for YOPA-mediated and chromosomally encoded mechanisms' [Details]
(1988)'Molecular cloning and expression of the coagulase gene of Staphylococcus aureus 8325-4'
Phonimdaeng, P., O'Reilly, M. O'Toole, P.W. Foster, T.J.; (1988) 'Molecular cloning and expression of the coagulase gene of Staphylococcus aureus 8325-4' [Details]
(1988)'Molecular cloning and expression of the coagulase gene of Staphylococcus aureus'
Phonimdaeng, P., M. O'Reilly, P.W. O'Toole and T.J. Foster. ; (1988) 'Molecular cloning and expression of the coagulase gene of Staphylococcus aureus' [Details]
(1987)'Nucleotide sequence of the epidermolytic toxin A gene of Staphylococcus aureus'
O'Toole, P.W. Foster, T.J.; (1987) 'Nucleotide sequence of the epidermolytic toxin A gene of Staphylococcus aureus' [Details]
(1986)'Epidermolytic toxin serotype B of Staphylococcus aureus is plasmid encoded. FEMS Microbiol. Letts. 36: 311-314'
O'Toole, P.W. Foster, T.J.; (1986) 'Epidermolytic toxin serotype B of Staphylococcus aureus is plasmid encoded. FEMS Microbiol. Letts. 36: 311-314' [Details]
(1986)'Molecular cloning and expression of the epidermolytic toxin A gene of Staphylococcus aureus'
O'Toole, P.W. T.J. Foster.; (1986) 'Molecular cloning and expression of the epidermolytic toxin A gene of Staphylococcus aureus' [Details]

Other Journals

 YearPublication
(2010)'Evaluating the latest high-throughput molecular techniques for the exploration of microbial gut communities'
Claesson MJ, O'Toole PW (2010) 'Evaluating the latest high-throughput molecular techniques for the exploration of microbial gut communities' Gut Microbes, . [Details]
(2008)'Lactobacillus salivarius modulates cytokine induction and virulence factor gene expression in Helicobacter pylori'
Ryan, K.A., O¿Hara, A.M., van Pijkeren, J.P., J.-P., Douillard, F., Li, Y., and P. W. O¿Toole; (2008) 'Lactobacillus salivarius modulates cytokine induction and virulence factor gene expression in Helicobacter pylori' '', . [Details]

Conference Publications

 YearPublication
(2010)Proc Natl Acad Sci U S A
Claesson, MJ; Cusack, S; O'Sullivan, O; Greene-Diniz, R; de Weerd, H; Flannery, E; Marchesi, JR; Falush, D; Dinan, T; Fitzgerald, G; Stanton, C; van Sinderen, D; O'Connor, M; Harnedy, N; O'Connor, K; Henry, C; O'Mahony, D; Fitzgerald, AP; Shanahan, F; Twomey, C;Hill, C; Ross, RP; O'Toole, PW; (2010) Microbes and Health Sackler Colloquium: Composition, variability, and temporal stability of the intestinal microbiota of the elderly Proc Natl Acad Sci U S A [Details]
(2010)Gastroenterology
OMahony SM; Savignac HM; O'Brien T; Scully P; Quigley EM; Marchesi, J; O'Toole, PW; Dinan TG; Cryan JF; (2010) Early-life Dysbiosis-Induced Visceral Hypersensitivity in Adulthood Gastroenterology [Details]
(2010)Microbes and Health Sackler Colloquium
Claesson, M. J; Cusack, S; O'Sullivan, O; Greene-Diniz, R; de Weerd, H; Flannery, E; Marchesi, J. R; Falush, D; Dinan, T; Fitzgerald, G; Stanton, C; van Sinderen, D; O'Connor, M; Harnedy, N; O'Connor, K; Henry, C; O'Mahony, D; Fitzgerald, A. P; Shanahan, F; Twomey, C; Hill, C; Ross, R. P; O'Toole, P. W.; (2010) Composition, variability, and temporal stability of the intestinal microbiota of the elderly Microbes and Health Sackler Colloquium [Details]
(2010)Microbes and Health Sackler Colloquium
Claesson, MJ; Cusack, S; O'Sullivan, O; Greene-Diniz, R; de Weerd, H; Flannery, E; Marchesi, JR; Falush, D; Dinan, T; Fitzgerald, G; Stanton, C; van Sinderen, D; O'Connor, M; Harnedy, N; O'Connor, K; Henry, C; O'Mahony, D; Fitzgerald, AP; Shanahan, F; Twomey, C;Hill, C; Ross, RP; O'Toole, PW; (2010) Composition, variability, and temporal stability of the intestinal microbiota of the elderly Microbes and Health Sackler Colloquium [DOI] [Details]

Conference Contributions

 YearPublication
(2006)Society for General Microbiology, Annual Meeting,
Claesson, M. Y Li S. Leahy C. Canchaya J.P. van Pijkeren Ana M. Cerdeño-Tárraga J. Parkhill S. Flynn G.C. O’Sullivan J. K. Collins D. Higgins F. Shanahan G. J. Fitzgerald D. van Sinderen P. W. O'Toole.; (2006) Multi-replicon genome architecture of Lactobacillus salivarius. [Poster Presentation], Society for General Microbiology, Annual Meeting, Univ. Warwick, UK , 02-APR-06 - 05-APR-06
(2005)Irish-Dutch Gut Health Research Meeting, with the Wageningen Centre for Food Sciences,
O'Toole, P.W. van Sinderen, D.; (2005) A new look at old friends: Genomes of Lactobacillus salivarius UCC118 and B. breve. [Invited Oral Presentation], Irish-Dutch Gut Health Research Meeting, with the Wageningen Centre for Food Sciences, University College Cork , 22-APR-05 - 22-APR-05
(2005)LAB8: Eighth symposium on Lactic Acid Bacteria,
O'Toole, P.W. . Claesson Y. Li S. Leahy S. Flynn G. Fitzgerald D. Van Sinderen.; (2005) Comparative genomics of the probiotic Lactobacillus salivarius subsp. salivarius strain UCC118. [Poster Presentation], LAB8: Eighth symposium on Lactic Acid Bacteria, Egmond aan Zee, Holland , 28-AUG-05 - 01-SEP-05
(2005)13th International Workshop on Campylobacter, Helicobacter and Related Organisms,
A.P. Moran W.J. Snelling J.J. McGovern P.W. O'Toole H. Annuk; (2005) Influence of knockouts in horB (HP0127) and virB11 (HP1421) on O-chain synthesis by lipopolysaccharide of Helicobacter pylori. [Poster Presentation], 13th International Workshop on Campylobacter, Helicobacter and Related Organisms, Queensland, Australia , 04-SEP-05 - 08-SEP-05
(2004)Bed to bedside,
O'Toole, P.W.; (2004) *. [Invited Oral Presentation], Bed to bedside, Mercy University Hospital , 09-MAR-04 - 09-MAR-04
(2004)Comparative Genomics of Gastric pathogens,
O'Toole, P.W.; (2004) 6th International Workshop on Pathogenesis and host response in Helicobacter Infections. [Invited Oral Presentation], Comparative Genomics of Gastric pathogens, Helsingor, Denmark , 23-JUN-04 - 26-JUN-04
(2004)Society for General Microbiology UK, Irish Branch Meeting,
Snelling, W. Moran, A. O'Toole, P.W.; (2004) Comparative analysis of the H. pylori an dHmustelae proteomes. [Poster Presentation], Society for General Microbiology UK, Irish Branch Meeting, NUI Galway, Ireland , 15-APR-04 - 16-APR-04
(2004)Digestive Disease Week,
Snelling, W. Ryan, K. Moran, A.P. O'Toole, P.W.; (2004) Role of VirB11 in the gastric pathogen Helicobacter pylori. [Poster Presentation], Digestive Disease Week, New Orleans , 05-MAY-04 - 06-MAY-04
(2004)SGM, Annual meeting,
Snelling, W. Moran, A.P. O'Toole, P.W.; (2004) Role of VirB11 in the gastric pathogen Helicobacter pylori: Comparative proteomics of H pylori and H mustelae, Preliminary comparative genomic analysis of Helicobacter mustelae. [Poster Presentation], SGM, Annual meeting, Trinity College Dublin , 02-SEP-04 - 02-SEP-04
(2003)Society for Applied Microbiology Irish branch annual meeting,
Snelling, W. Moran, A.P. O'Toole, P.W.; (2003) Role of VirB11 in the gastric pathogen Helicobacter pylori: Comparative proteomics of H pylor and H mustelae. [Poster Presentation], Society for Applied Microbiology Irish branch annual meeting, Cork , 02-JUL-03 - 05-JUL-03
(2002)Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC),
Huang, J. O'Toole, P.W., Shen, W. Madsen, .A. Jiang, X. Lobo, N. Palmer, L.M. Voelker, L. Fan, F. Gwynn, M. D. McDevitt.; (2002) Identification of a novel multi-drug transporter MdeA in Staphylococcus aureus. [Poster Presentation], Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), San Diego, USA , 01-SEP-02 - 02-SEP-02
(2002)Seventh symposium on lactic acid bacteria,
Schiemann, A Rakonjac, R. Lubbers, M. O'Toole, P.W.; (2002) The role of transcription in lactococcal phage replication. [Poster Presentation], Seventh symposium on lactic acid bacteria, Egmond aan Zee, Holland , 29-SEP-02 - 30-SEP-02
(1999)IRCSET meeting,
Snelling, W. Moran, A.P. O'Toole, P.W.; (1999) Role of VirB11 in the gastric pathogen Helicobacter pylori. [Invited Oral Presentation], IRCSET meeting, Royal Kilmainham Hospital , 30-DEC-99 - 30-DEC-99

Abstract

 YearPublication
(2007)Lactobacillus-mediated modulation of gastric epithelial responses to Helicobacter pylori.
Ryan, KA,van Pijkeren, JP,O'Hara, AM,Li, Y,O'Toole, PW (2007) Lactobacillus-mediated modulation of gastric epithelial responses to Helicobacter pylori. Abstract [Details]
(2005)Influence of knockouts in HorB (HP1421) and virB11 (HP0127) on O-chain synthesis by lipopolysaccharide of Helicobacter pylori.
Moran, AP,Snelling, WJ,McGovern, JJ,O'Toole, PW,Annuk, H (2005) Influence of knockouts in HorB (HP1421) and virB11 (HP0127) on O-chain synthesis by lipopolysaccharide of Helicobacter pylori. Abstract [Details]
(2005)HP0906 controls flagellar hook-filament transition in Helicobacter pylori.
Ryan, KA,Karim, N,Worku, M,Penn, CW,O'Toole, PW (2005) HP0906 controls flagellar hook-filament transition in Helicobacter pylori. Abstract [Details]

Book Review

 YearPublication
(2007)The FliK protein and flagellar hook-length control.
Waters, RC,O'Toole, PW,Ryan, KA (2007) The FliK protein and flagellar hook-length control. Book Reviews [DOI] [Details]
(2009)Genetic tools for investigating the biology of commensal lactobacilli.
Fang, F,O'Toole, PW (2009) Genetic tools for investigating the biology of commensal lactobacilli. Book Reviews [DOI] [Details]
(2009)Genome-scale analyses of health-promoting bacteria: probiogenomics.
Ventura, M,O'Flaherty, S,Claesson, MJ,Turroni, F,Klaenhammer, TR,van Sinderen, D,O'Toole, PW (2009) Genome-scale analyses of health-promoting bacteria: probiogenomics. Book Reviews [DOI] [Details]
(2010)Gut microbiota: Changes throughout the lifespan from infancy to elderly.
O'Toole, PW,Claesson, MJ (2010) Gut microbiota: Changes throughout the lifespan from infancy to elderly. Book Reviews [DOI] [Details]
(2010)Probiotic properties of Lactobacillus salivarius and closely related Lactobacillus species.
Neville, BA,O'Toole, PW (2010) Probiotic properties of Lactobacillus salivarius and closely related Lactobacillus species. Book Reviews [DOI] [Details]
(2012)Categorization of the gut microbiota: enterotypes or gradients?.
Jeffery, IB,Claesson, MJ,O'Toole, PW,Shanahan, F (2012) Categorization of the gut microbiota: enterotypes or gradients?. Book Reviews [DOI] [Details]
(2012)Techniques used to characterize the gut microbiota: a guide for the clinician.
Fraher, MH,O'Toole, PW,Quigley, EMM (2012) Techniques used to characterize the gut microbiota: a guide for the clinician. Book Reviews [DOI] [Details]

Editorial

 YearPublication
(2010)Special issue: The Human Intestinal Microbiota.
Flint, HJ,O'Toole, PW,Walker, AW; (2010) Special issue: The Human Intestinal Microbiota. Editorial [DOI] [Details]

Honours and Awards

 YearTitleAwarding Body
2002Best poster award Interscience Conference on Antimicrobial Agents and Chemotherapy, San Diego
2006Nestle Award for phage research published in the Journal of Bacteriology Nestle Research

Associations

 AssocationFunctionFrom / To
Journal of Microbiology Associate Editor/

Patents

 Patent NumberTitleInventorGranted
Ser No. 634,238Genes of Lactobacillus rhamnosus and their predicted gene products and their use in engineering properties of food microorganisms. Glenn, M., Havukkala, I.J., Bloksberg, L.N., Lubbers, M.W., Dekker, J., Christensson, A.C., Holland, R., O'Toole, P.W., Reid, J.R., and T.C. Coolbear.01-JAN-02
A1 20020214Lactobacillus rhamnosus polynucleotides and their encoded polypeptides and their use in manufacture of dairy products and anti-infection agents Glenn, M., Havukkala, I.J., Bloksberg, L.N., Lubbers, M.W., Dekker, J., Christensson, A.C., Holland, R., O'Toole, P.W., Reid, J.R., and T.C. Coolbear.01-JAN-02
WO2007020617A product; Megaplasmid and sortase proteins ¿ megaplasmid of Lactobacillus salivarius UCC118. O¿Toole, P.W. and G.J. Fitzgerald01-AUG-05

Employment

 EmployerPositionFrom / To
Department of Biochem. & Microbiol., Univ. of Victoria, BC, Canada. Research Associate01-JUN-92 / 01-JUN-94
Microbiology, UCC Senior Lecturer01-JUL-02 / 31-DEC-10
Anti-Infectives and Drug Discovery, GlaxoSmithKline R&D, Collegeville, Pennsylvania, Visiting Scientist01-JAN-01 / 31-DEC-01
Massey University, Palmerston North, New Zealand Senior Lecturer01-JUN-95 / 01-JUN-01

Education

 YearInstituionQualificationSubject
1984Trinity College Dublin BANat. Science
1987Trinity College Dublin PHD''

Other Activities

 Description

Visiting Academics

Jan-July 2008: Prof Yifang Zhang. Kunming University, China. Sabbatical visit.

Jan-Dec 2008: Ms. Elisa Salvetti, Univ. Verona. Diploma lab placement.




Research Talks

• "The role of transcription in lactococcal phage replication".Seventh symposium on lactic acid bacteria, Egmond aan Zee, Holland, September 2002 (Poster communication)

• "Identification of a novel multi-drug transporter MdeA in Staphylococcus aureus". Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), San Diego, September 2002 (Poster presentation)

• "Bacterial efflux proteins, and other obstacles to genomics-based antibiotic discovery". Department of Microbiology, UCC, December 2002 (formal seminar)

• "Genomics of Drug Discovery and Drug efflux". Department of Chemical and Environmental Sciences, Univ. Limerick, February, 2003 (Invited seminar)

• "Bacterial Genomics and Drug Discovery". Department of Microbiology, NUI Galway, February 2003 (Invited seminar)

• Society for General Microbiology, 153rd meeting, Manchester 8-11 September 2003 (workshop delegate).

• Irish Research Council for Science, Engineering and Technology, annual symposium, Royal Hospital Kilmainham, Dublin. November 2003 (poster presentation)

• "The genus Helicobacter: Game, set and match?". Mercy University Hospital Bench to bedside Seminar series, Mercy Hospital, March 9th 2004 (Invited lecture)

• Society for General Microbiology UK, Irish Branch Meeting, Galway April 15-16th 2004 (two poster presentations)

• Digestive Disease Week, New Orleans USA, May 15-20th 2004. Adhesin functions of the outer membrane protein HorB in the human gastric pathogen H. pylori. (poster)

• Comparative Genomic Analysis of Helicobacter mustelae and Helicobacter pylori. 6th International Workshop on Pathogenesis and Host Response in Helicobacter Infections, Helsingor, Denmark, June 23-26 2004. Julian Parkhill, Karen Mungall, Ian Goodhead and Paul W. O'Toole (Invited lecture plus associated publication; two poster presentations)

• Society for Applied Microbiology UK, 2004 Summer Conference, July 12-15, 2004, Cork (two posters)

• Society for General Microbiology, General Meeting, Trinity College Dublin, 6th-9th September 2004 (three posters)

• IRCSET Embark Initiative National Sympsium, Croke Park, Dublin. November 2nd, 2004 (two posters)

• A new look at old friends: Genomes of Lactobacillus salivarius UCC118 and B. breve. Irish-Dutch Gut Health Research Meeting, with the Wageningen Centre for Food Sciences. Kane G-19, April 22nd 2005 (Invited lecture).

• Society for General Microbiology UK, Irish Branch Meeting, Cork, April 28-29th 2005 (two posters)

• World Congress of Gastroenterology, Montreal, Sept 10-14, 2005. Poster presentation. HP0906 encodes a Helicobacter pylori FliK functional homologue. Kieran A. Ryan, Najma Karim, Muguleeta Worku, Ann M. O'Hara, Charles Penn, and Paul W. O'Toole.

• O'Toole, P.W., M. Claesson, Y. Li, S. Leahy, S. Flynn, G. Fitzgerald, and D. Van Sinderen. (2005). Comparative genomics of the probiotic Lactobacillus salivarius subsp. salivarius strain UCC118. LAB8: Eighth symposium on Lactic Acid Bacteria, Egmond aan Zee, Holland, August 28th-September 1st, 2005. Poster.

• Li, Y.,, G. Mulcahy, D. Van Sinderen, P. W. O'Toole. (2005). Production of ABP-118, a bacteriocin identified in Lactobacillus salivarius UCC118, is a relatively common feature of L. salivarius strains from chicken gastrointestinal tracts. LAB8: Eighth symposium on Lactic Acid Bacteria, Egmond aan Zee, Holland, August 28th-September 1st, 2005. Poster.

• Van Pijkeren, J.P., Y. Li, M. Claesson, B. Sheil,S. Leahy, K. A. Ryan, C. Canchaya, L. Steidler, L. O'Mahony, G. Fitzgerald, D. van Sinderen and P. W. O'Toole. (2005). Functional genomics of surface proteins in the probiotic bacterium Lactobacillus salivarius subsp. salivarius strain UCC118. LAB8: Eighth symposium on Lactic Acid Bacteria, Egmond aan Zee, Holland, August 28th-September 1st, 2005. Poster.

• HP0906 controls flagellar hook-filament transition in Helicobacter pylori. Ryan, K.A., Karim, N., Worku, M., Penn, C.W. and O'Toole, P.W. Presented at the European Helicobacter Study Group, Copenhagen, Denmark, October 2005 (Invited lecture).

• O'Toole, P.W. (2005). Helicobacter pylori comparative genomics - what has it taught us? Union of European Gastroenterology Week (UEGW) 2005, Copenhagen, Denmark, October 18th 2005 (Invited lecture)

• A.P. Moran, W.J. Snelling, J.J. McGovern, P.W. O'Toole and H. Annuk
Influence of knockouts in horB (HP0127) and virB11 (HP1421) on O-chain
synthesis by lipopolysaccharide of Helicobacter pylori In: Abstracts of the 13th International Workshop on Campylobacter, Helicobacter and Related Organisms, pg. 95, Abstract G14 (September 4-8, 2005; Queensland, Australia). Poster.

• O'Toole, P.W. 2006. Genetics and biochemistry of Helicobacter pylori flagellum biogenesis. Conway Institute, University College Dublin, Invited seminar. February 22nd, 2006.

• O'Toole, P.W. 2006. Comparative and functional genomics of the probiotic bacterium Lactobacillus salivarius UCC118. Division of Structural Biology, The Henry Wellcome Center for Genomic Medicine, Univ. Oxford. Invited seminar, March 21st, 2006.

• M. O'Connell, P. Mouat, K. McGourty, K. Lynch, P. W.O'Toole, M. Paoli, T. Kagawa, and J.C. Cooney. 2006. Structural Analysis of a cell envelope protease. Society for General Microbiology, Irish Branch Meeting, Trinity College Dublin, April 27-28th 2006 (poster).

• Kieran A. Ryan, Kieran McGourty, Najma Karim and Paul W. O'Toole. Adhesion and cytokine induction profiles of two Helicobacter pylori motility mutants. Society for General Microbiology, Irish Branch Meeting, Trinity College Dublin, April 27-28th 2006. (poster)

• Claesson, M., Y Li, S. Leahy, C. Canchaya, J.P. van Pijkeren, Ana M. Cerdeño-Tárraga, J. Parkhill, S. Flynn, G.C. O'Sullivan, J. K. Collins, D. Higgins, F. Shanahan, G. J. Fitzgerald, D. van Sinderen and P. W. O'Toole. Multi-replicon genome architecture of Lactobacillus salivarius. Society for General Microbiology, Annual Meeting, Univ. Warwick, UK, 2nd - 5th April 2006 (poster)

• Molecular Pathogenesis of gastric and enterohepatic Helicobacter species. Infectious Diseases Symposium, UCC Faculty of Medicine and Faculty of Science, Brookfield Health Science Complex, April 6th 2006. Seminar.

• O'Toole, P.W. 2006. Molecular genetics of pathogenic and probiotic bacteria: an overview. Symposium, Dept. Chemical and Environmental Sciences & Materials and Surface Sciences Institute, Univ. Limerick, May 25th, 2006. Invited seminar.

• O'Toole, P.W. 2006. Genomics of protein secretion in probiotic lactobacilli. 4th meeting of the International Scientific Association for Probiotics and Prebiotics. Coleraine, Northern Ireland, June 16-18, 2006. Invited speaker.

• O'Toole, P.W. 2006. Comparative and functional genomics of the probiotic Lactobacillus salivarius strain UCC118. Invited seminar, School of Biosciences, Univ. of Birmingham, UK., October 18th, 2006.

• O'Toole, P.W. 2006. Comparative and functional genomics of the probiotic Lactobacillus salivarius strain UCC118. Invited seminar, Department of Microbiology, Trinity College Dublin, November 3rd, 2006.

• O'Toole, P.W. 2006. Comparative & functional genomics of the probiotic bacterium Lactobacillus salivarius UCC118. Invited seminar, AgResearch Ltd., Palmerston North, New Zealand, November 27th, 2006.

• O'Toole, P.W. 2006. Comparative & functional genomics of the probiotic bacterium Lactobacillus salivarius UCC118. Invited seminar, Dept. Microbiology, Univ. of Otago, Dunedin, New Zealand, December 7th, 2006.

• O'Toole, P.W. 2007. Comparative & functional genomics of the probiotic bacterium Lactobacillus salivarius UCC118. Invited seminar, Materials and Surface Sciences Institute, Univ. Limerick, February 8th, 2007

• O'Toole, P.W. 2007. Comparative & functional genomics of the probiotic bacterium Lactobacillus salivarius UCC118. Invited seminar, Dept. Cell and Organismal Biology, University of Lund, Sweden, March 14h, 2007.

• O'Toole, P.W. 2007. Comparative & functional genomics of the probiotic bacterium Lactobacillus salivarius UCC118. Invited seminar, Dept. Microbiology, Swedish Agricultural University, March 15th, 2007.

• Claesson, M.J., van Sinderen, D. and P. W. O'Toole. Expanded phylogenetic analysis of the Lactobacillus genus. 6th European Conference on Computational Biology (ECCB), Vienna, Austria: July 21-25, 2007, poster communication

• O'Toole, P.W. 2007. Comparative genomics of Lactobacillus species. 107th General Meeting of the American Society for Microbiology, May 23rd 2007, Toronto, Canada. Invited speaker.

• O'Toole, P.W. 2007. Functional genomics of the human probiotic bacterium Lactobacillus salivarius UCC118. Invited seminar, Department of Biochemistry, Univ. of Saskatchewan, Saskatoon, Canada, May 24th 2007.

• Ryan, K.A., van Pijkeren, J.P., O'Hara, A.M., Li, Y. and O'Toole, P.W. 2007. Lactobacillus-mediated modulation of gastric epithelial responses to Helicobacter pylori. 20th International Workshop of the European Helicobacter Study Group - EHPSG: Helicobacter and related bacteria in chronic digestive inflammation. Istanbul, Turkey, 20-22 September, 2007. Helicobacter 12(4):406. Poster.

• O'Toole, P.W. 2007. Comparative & functional genomics of a probiotic Lactobacillus. Queenstown Molecular Biology Society Meeting, Queenstown New Zealand, August 28th -31st 2007. Invited plenary lecture.

• Fang Fang, Douwe van Sinderen, and Paul W. O'Toole. 2007. Characterization and adaptation of plasmids in Lactobacillus salivarius. International Yakult Symposium: The Gut, Immune Modulation and Probiotics. Verona November 22nd - 23rd, 2007. Poster.

• Intraspecies diversity of Lactobacillus salivarius. Emma Raftis and P.W. O'Toole. International Yakult Symposium: The Gut, Immune Modulation and Probiotics. Verona November 22nd - 23rd, 2007. Poster.

• Claesson, M.J., D. van Sinderen and P.W. O'Toole. Phylogenomic analysis of the genus lactobacillus as a basis for its reclassification. LAB9 Symposium on lactic acid bacteria, Egmond aan Zee, Holland, August 31-September 4, 2008. Poster.

• E. Raftis and P.W. O'Toole. Genomic diversity in L. salivarius. LAB9 Symposium on lactic acid bacteria, Egmond aan Zee, Holland, August 31-September 4, 2008. Poster.

• Blastxtract2 - improving the early exploitation of (meta)genomic sequences by intuitive visualization and management. LAB9 Symposium on lactic acid bacteria, Egmond aan Zee, Holland, August 31-September 4, 2008. Poster.

• F. Fang, D. van Sinderen and P.W. O'Toole. Development and applicatio of novel egentic tools for Lactobacillus salivarius. LAB9 Symposium on lactic acid bacteria, Egmond aan Zee, Holland, August 31-September 4, 2008. Poster.

• C.M. Wilson, P.W. O'Toole, and G.W. Tannock. Lactobacillus dialogues: the impact of cell signalling on gene expression and ecological behavious of a gut commensal. LAB9 Symposium on lactic acid bacteria, Egmond aan Zee, Holland, August 31-September 4, 2008. Poster

• Mangan, W.D, and P.W. O'Toole. The interaction between the replicons of Lactobacillus salivarius UCC118 during growth under diverse conditions. LAB9 Symposium on lactic acid bacteria, Egmond aan Zee, Holland, August 31-September 4, 2008. Poster.

• O'Toole, P.W. Gut microbiota as an indicator and agent of nutritional health in elderly Irish subjects. International Human Microbiome Consortium meeting, Heidelberg, October 15-16, 2008. Poster.


List of Expert Assignments

2004 - Reviewer, Dutch Innovation-Oriented Research Program (IOP). Holland and Ireland.
2004 - Medical Research Council (UK), Infections and Immunity panel, research grant reviewer. UK and Ireland.
2005 - Reviewer and Panel Leader, European Commission 6th Framework (FP6) LIFESCIHEALTH-6. Brussels.
2006 - Biotechnology and Biological Sciences Research Council (UK) Research Grant application Genes and Developmental Biology section. UK and Ireland.
2007 - Reviewer European Commission 7th Framework (FP7). Brussels.

Clarke SiobhanDoctoral DegreeCo-SupervisedPower Susan EleanorDoctoral DegreeCo-SupervisedLakshminarayanan BhuvaneswariDoctoral DegreeO Donnell Michelle MarieDoctoral DegreeCo-SupervisedButto LudovicaDoctoral DegreeClancy Ceara Ann De LacyDoctoral Degree
 Term (ID))TitleLinkSubject
2014Literature Project on Genetics GN3002Literature Project on Genetics
2014Research Frontiers in Microbiology MB4027Research Frontiers in Microbiology
2014Research Project MB4002Research Project
2014Research Project GN4002Research Project
2014Genetics and Society GN4004Genetics and Society
2014Current Perspectives in Genetics GN2001Current Perspectives in Genetics
2014Principles and Methods in Genetics GN6006Principles and Methods in Genetics
2014Principles and Methods in Genetics GN1006Principles and Methods in Genetics
2014Genomics and Applications GN4003Genomics and Applications