Professor Ruth Massey has a B.A. in Natural Sciences and a Ph.D. in Molecular Microbiology from Trinity College Dublin. She worked as a postdoctoral researcher in the UK at both the University of Oxford and Bath, and it was in Oxford where her interest in Gram positive bacterial pathogen began. Ruth’s first independent position was in the Zoology Dept. in Oxford, where Wellcome Trust funding allowed her to set up her first lab, which subsequently moved to Bath in 2007. In 2017 Ruth moved to the University of Bristol and in 2019 was awarded a Wellcome Trust Investigator Award and promoted to Professor of Microbial Pathogenicity. In 2021 Ruth became the SALI Professor for Microbiome and Health Sciences at UCC. In July 2023 she was inducted as a Member into the prestigious European Molecular Biology Organization (EMBO).
Infectious diseases are among the greatest causes of morbidity and mortality globally. With a dwindling pool of effective antibiotics, pharmaceutical companies shutting down their antibiotic development facilities, and many pathogens remaining recalcitrant to effective vaccine development, new and innovative approaches to infection management and treatment regimens are desperately needed. But without a greater understanding of how bacteria cause disease, we are largely working in the dark, and addressing this has been the focus of Ruth’s research career.
Understanding the interconnectivity between bacterial virulence and antibiotic resistance. There is a delicate balance to be reached by bacterial pathogens between being highly virulent or fully antibiotic resistant, as they are rarely able to be both due to the energetic costs associated both bacterial strategies. Work by Ruth and her team uncovered much of this for the major human pathogen Staphylococcus aureus, where detailed molecular analysis revealed the in-built redundancies and interconnectivity between these strategies that have contributed to the design of clinical trials of potential anti-virulence strategies.
Developing the use of genome sequence data to define bacterial phenotypes and predict patient outcome following infection. One of Ruth’s major scientific contributions to date began as a concept that molecular and computational approaches could be used to study bacterial phenotypes at a population level, through the development of novel functional genomics approaches. Her team’s first demonstration of the utility of these functional genomics approach with empirical data was published two years later where they successfully predicted the toxicity of individual MRSA isolates from their genome sequence, a seminal paper that has been recommended by Faculty 1000 (https://f1000.com/prime/718345576). To date Ruth’s team’s research approach has facilitated the identification over a dozen novel pathogenicity affecting loci. As they characterise the molecular detail of how each of these loci affect the ability of S. aureus to produce toxins, they are uncovering hidden depths to the complexity that is involved and identifying novel pathways for future therapeutic intervention.
Development of functional genomics approaches to predict patient outcome following infection. Since Ruth’s early publications in the arena, her research team and have been building upon the complexity of what they are trying to understand about bacterial pathogens. By including information on the source of the infection, they have uncovered hidden subtleties about specific conditions such as the development of and outcome following S. aureus bacteraemia. With the inclusion of patient meta-data they have also been successful in both predicting individual patient mortality, but also identifying several novel features associated with this, including several previously uncharacterised S. aureus proteins. Her most recent work has applied this approach to COVID-19 patient samples demonstrating its utility to combine AMR, host immunity as well as bacterial virulence to understand disease development.
Biography
BiographyProfessor Ruth Massey has a B.A. in Natural Sciences and a Ph.D. in Molecular Microbiology from Trinity College Dublin. She worked as a postdoctoral researcher in the UK at both the University of Oxford and Bath, and it was in Oxford where her interest in Gram positive bacterial pathogen began. Ruth’s first independent position was in the Zoology Dept. in Oxford, where Wellcome Trust funding allowed her to set up her first lab, which subsequently moved to Bath in 2007. In 2017 Ruth moved to the University of Bristol and in 2019 was awarded a Wellcome Trust Investigator Award and promoted to Professor of Microbial Pathogenicity. In 2021 Ruth became the SALI Professor for Microbiome and Health Sciences at UCC. In July 2023 she was inducted as a Member into the prestigious European Molecular Biology Organization (EMBO).
Research Interests
Research InterestsInfectious diseases are among the greatest causes of morbidity and mortality globally. With a dwindling pool of effective antibiotics, pharmaceutical companies shutting down their antibiotic development facilities, and many pathogens remaining recalcitrant to effective vaccine development, new and innovative approaches to infection management and treatment regimens are desperately needed. But without a greater understanding of how bacteria cause disease, we are largely working in the dark, and addressing this has been the focus of Ruth’s research career.
Understanding the interconnectivity between bacterial virulence and antibiotic resistance. There is a delicate balance to be reached by bacterial pathogens between being highly virulent or fully antibiotic resistant, as they are rarely able to be both due to the energetic costs associated both bacterial strategies. Work by Ruth and her team uncovered much of this for the major human pathogen Staphylococcus aureus, where detailed molecular analysis revealed the in-built redundancies and interconnectivity between these strategies that have contributed to the design of clinical trials of potential anti-virulence strategies.
Developing the use of genome sequence data to define bacterial phenotypes and predict patient outcome following infection. One of Ruth’s major scientific contributions to date began as a concept that molecular and computational approaches could be used to study bacterial phenotypes at a population level, through the development of novel functional genomics approaches. Her team’s first demonstration of the utility of these functional genomics approach with empirical data was published two years later where they successfully predicted the toxicity of individual MRSA isolates from their genome sequence, a seminal paper that has been recommended by Faculty 1000 (https://f1000.com/prime/718345576). To date Ruth’s team’s research approach has facilitated the identification over a dozen novel pathogenicity affecting loci. As they characterise the molecular detail of how each of these loci affect the ability of S. aureus to produce toxins, they are uncovering hidden depths to the complexity that is involved and identifying novel pathways for future therapeutic intervention.
Development of functional genomics approaches to predict patient outcome following infection. Since Ruth’s early publications in the arena, her research team and have been building upon the complexity of what they are trying to understand about bacterial pathogens. By including information on the source of the infection, they have uncovered hidden subtleties about specific conditions such as the development of and outcome following S. aureus bacteraemia. With the inclusion of patient meta-data they have also been successful in both predicting individual patient mortality, but also identifying several novel features associated with this, including several previously uncharacterised S. aureus proteins. Her most recent work has applied this approach to COVID-19 patient samples demonstrating its utility to combine AMR, host immunity as well as bacterial virulence to understand disease development.
Research Grants
Project | Funding Body | Start Date | End Date | Award | |
---|---|---|---|---|---|
Science Foundation of Ireland | 01-DEC-22 | 30-NOV-27 | €1,274,004.00 | ||
An integrative approach to characterise colonisation-to-disease progression in hospital-acquired inf | Enterprise Irl | 22-JUL-21 | 21-JUL-22 | €15,489.00 |
Contract Researchers
Researcher Name | Project | Role | Funding Body | |
---|---|---|---|---|
Dr Samuel Fenn | Attack and Defence: defining key bacterial pathogenic strategies to identify targets for therapeutic intervention | Postdoctoral Researcher | Science Foundation Ireland | |
Dr Lizzie Legend | Attack and Defence: defining key bacterial pathogenic strategies to identify targets for therapeutic intervention | Postdoctoral Researcher | Science Foundation Ireland |
Publications
Peer Reviewed Journals
Year | Publication | |
---|---|---|
(2024) | 'Lipoteichoic acid biosynthesis by Staphylococcus aureus is controlled by the MspA protein' Bonini D;Duggan S;Alnahari A;Brignoli T;Strahl H;Massey RC; (2024) 'Lipoteichoic acid biosynthesis by Staphylococcus aureus is controlled by the MspA protein'. Mbio, 15 (8) [DOI] [Details] | |
(2024) | 'PBP4 is required for serum-induced cell wall thickening and antibiotic tolerance in Staphylococcus aureus' Ledger EVK;Massey RC; (2024) 'PBP4 is required for serum-induced cell wall thickening and antibiotic tolerance in Staphylococcus aureus'. Antimicrobial Agents and Chemotherapy, 68 (11) [DOI] [Details] | |
(2023) | 'Extensive re-modelling of the cell wall during the development of Staphylococcus aureus bacteraemia' Douglas EJA;Palk N;Brignoli T;Altwiley D;Boura M;Laabei M;Recker M;Cheung GYC;Liu R;Hsieh RC;Otto M;Oâ Brien E;McLoughlin RM;Massey RC; (2023) 'Extensive re-modelling of the cell wall during the development of Staphylococcus aureus bacteraemia'. Biorxiv : The Preprint Server For Biology, [DOI] [Details] | |
(2023) | 'Triclosan-resistant small-colony variants of Staphylococcus aureus produce less capsule, less phenol-soluble modulins, and are attenuated in a Galleria mellonella model of infection' Altwiley D;Brignoli T;Duggan S;Massey RC; (2023) 'Triclosan-resistant small-colony variants of Staphylococcus aureus produce less capsule, less phenol-soluble modulins, and are attenuated in a Galleria mellonella model of infection'. Microbiology-SGM, 169 (1) [DOI] [Details] | |
(2023) | 'Questioning the fetal microbiome illustrates pitfalls of low-biomass microbial studies' Kennedy KM;de Goffau MC;Perez-Muñoz ME;Arrieta MC;Bäckhed F;Bork P;Braun T;Bushman FD;Dore J;de Vos WM;Earl AM;Eisen JA;Elovitz MA;Ganal-Vonarburg SC;Gänzle MG;Garrett WS;Hall LJ;Hornef MW;Huttenhower C;Konnikova L;Lebeer S;Macpherson AJ;Massey RC;McHardy AC;Koren O;Lawley TD;Ley RE;O'Mahony L;O'Toole PW;Pamer EG;Parkhill J;Raes J;Rattei T;Salonen A;Segal E;Segata N;Shanahan F;Sloboda DM;Smith GCS;Sokol H;Spector TD;Surette MG;Tannock GW;Walker AW;Yassour M;Walter J; (2023) 'Questioning the fetal microbiome illustrates pitfalls of low-biomass microbial studies'. Nature, 613 (7945) [DOI] [Details] | |
(2022) | 'Wall Teichoic Acids Facilitate the Release of Toxins from the Surface of Staphylococcus aureus' Brignoli, T;Douglas, E;Duggan, S;Fagunloye, OG;Adhikari, R;Aman, MJ;Massey, RC (2022) 'Wall Teichoic Acids Facilitate the Release of Toxins from the Surface of Staphylococcus aureus'. Microbiology Spectrum, [DOI] [Details] | |
(2022) | 'Diagnostic MALDI-TOF MS can differentiate between high and low toxic Staphylococcus aureus bacteraemia isolates as a predictor of patient outcome' Brignoli, Tarcisio; Recker, Mario; Lee, Winnie W. Y.; Dong, Tim; Bhamber, Ranjeet; Albur, Mahableshwar; Williams, Philip; Dowsey, Andrew W.; Massey, Ruth C. (2022) 'Diagnostic MALDI-TOF MS can differentiate between high and low toxic Staphylococcus aureus bacteraemia isolates as a predictor of patient outcome'. Microbiology (Reading, England), 168 (8):1-6 [DOI] [Full Text] [Details] | |
(2022) | 'Targeted control of pneumolysin production by a mobile genetic element in Streptococcus pneumoniae' Stevens, Emily J.; Morse, Daniel J.; Bonini, Dora; Duggan, Seana; Brignoli, Tarcisio; Recker, Mario; Lees, John A.; Croucher, Nicholas J.; Bentley, Stephen; Wilson, Daniel J.; Earle, Sarah G.; Dixon, Robert; Nobbs, Angela; Jenkinson, Howard; van Opijnen, Tim; Thibault, Derek; Wilkinson, Oliver J.; Dillingham, Mark S.; Carlile, Simon; McLoughlin, Rachel M.; Massey, Ruth C. (2022) 'Targeted control of pneumolysin production by a mobile genetic element in Streptococcus pneumoniae'. Microbial Genomics, 8 (4):1-14 [DOI] [Full Text] [Details] | |
(2021) | 'A functional menadione biosynthesis pathway is required for capsule production by Staphylococcus aureus' Altwiley, D.; Brignoli, T.; Edwards, A.; Recker, M.; Lee, J. C.; Massey, R. C. (2021) 'A functional menadione biosynthesis pathway is required for capsule production by Staphylococcus aureus'. Microbiology (Reading, England), 167 (11):1-11 [DOI] [Full Text] [Details] | |
(2021) | 'Significant variability exists in the cytotoxicity of global methicillin-resistant Staphylococcus aureus lineages' Laabei M;Peacock SJ;Blane B;Baines SL;Howden BP;Stinear TP;Massey RC; (2021) 'Significant variability exists in the cytotoxicity of global methicillin-resistant Staphylococcus aureus lineages'. Microbiology-SGM, 167 (12) [DOI] [Details] | |
(2021) | 'The MpsB protein contributes to both the toxicity and immune evasion capacity of Staphylococcus aureus' Douglas, Edward J. A.; Duggan, Seána, Brignoli, Tarcisio; Massey, Ruth C. (2021) 'The MpsB protein contributes to both the toxicity and immune evasion capacity of Staphylococcus aureus'. Microbiology (Reading, England), 167 (10):1-8 [DOI] [Full Text] [Details] | |
(2020) | 'Post-acute COVID-19 associated with evidence of bystander T-cell activation and a recurring antibiotic-resistant bacterial pneumonia' Gregorova M;Morse D;Brignoli T;Steventon J;Hamilton F;Albur M;Arnold D;Thomas M;Halliday A;Baum H;Rice C;Avison MB;Davidson AD;Santopaolo M;Oliver E;Goenka A;Finn A;Wooldridge L;Amulic B;Boyton RJ;Altmann DM;Butler DK;McMurray C;Stockton J;Nicholls S;Cooper C;Loman N;Cox MJ;Rivino L;Massey RC; (2020) 'Post-acute COVID-19 associated with evidence of bystander T-cell activation and a recurring antibiotic-resistant bacterial pneumonia'. Elife, 9 [DOI] [Details] | |
(2020) | 'A Small Membrane Stabilizing Protein Critical to the Pathogenicity of Staphylococcus aureus' Duggan S;Laabei M;Alnahari AA;O'Brien EC;Lacey KA;Bacon L;Heesom K;Fu CL;Otto M;Skaar E;McLoughlin RM;Massey RC; (2020) 'A Small Membrane Stabilizing Protein Critical to the Pathogenicity of Staphylococcus aureus'. Infection and Immunity, 88 (9) [DOI] [Details] | |
(2019) | 'Genomic identification of cryptic susceptibility to penicillins and ß-lactamase inhibitors in methicillin-resistant Staphylococcus aureus' Harrison EM;Ba X;Coll F;Blane B;Restif O;Carvell H;Köser CU;Jamrozy D;Reuter S;Lovering A;Gleadall N;Bellis KL;Uhlemann AC;Lowy FD;Massey RC;Grilo IR;Sobral R;Larsen J;Rhod Larsen A;Vingsbo Lundberg C;Parkhill J;Paterson GK;Holden MTG;Peacock SJ;Holmes MA; (2019) 'Genomic identification of cryptic susceptibility to penicillins and ß-lactamase inhibitors in methicillin-resistant Staphylococcus aureus'. Nature Microbiology, 4 (10) [DOI] [Details] | |
(2019) | 'Evolution and Global Transmission of a Multidrug-Resistant, Community-Associated Methicillin-Resistant Staphylococcus aureus Lineage from the Indian Subcontinent' Steinig EJ;Duchene S;Robinson DA;Monecke S;Yokoyama M;Laabei M;Slickers P;Andersson P;Williamson D;Kearns A;Goering RV;Dickson E;Ehricht R;Ip M;O'Sullivan MVN;Coombs GW;Petersen A;Brennan G;Shore AC;Coleman DC;Pantosti A;de Lencastre H;Westh H;Kobayashi N;Heffernan H;Strommenger B;Layer F;Weber S;Aamot HV;Skakni L;Peacock SJ;Sarovich D;Harris S;Parkhill J;Massey RC;Holden MTG;Bentley SD;Tong SYC; (2019) 'Evolution and Global Transmission of a Multidrug-Resistant, Community-Associated Methicillin-Resistant Staphylococcus aureus Lineage from the Indian Subcontinent'. Mbio, 10 (6) [DOI] [Details] | |
(2019) | 'Timing Is Everything: Impact of Naturally Occurring Staphylococcus aureus AgrC Cytoplasmic Domain Adaptive Mutations on Autoinduction' Sloan TJ;Murray E;Yokoyama M;Massey RC;Chan WC;Bonev BB;Williams P; (2019) 'Timing Is Everything: Impact of Naturally Occurring Staphylococcus aureus AgrC Cytoplasmic Domain Adaptive Mutations on Autoinduction'. Journal of Bacteriology, 201 (20) [DOI] [Details] | |
(2018) | 'Epistasis analysis uncovers hidden antibiotic resistance-associated fitness costs hampering the evolution of MRSA' Yokoyama M;Stevens E;Laabei M;Bacon L;Heesom K;Bayliss S;Ooi N;O'Neill AJ;Murray E;Williams P;Lubben A;Reeksting S;Meric G;Pascoe B;Sheppard SK;Recker M;Hurst LD;Massey RC; (2018) 'Epistasis analysis uncovers hidden antibiotic resistance-associated fitness costs hampering the evolution of MRSA'. Genome Biology, 19 (1) [DOI] [Details] | |
(2018) | 'Genomic exploration of sequential clinical isolates reveals a distinctive molecular signature of persistent Staphylococcus aureus bacteraemia' Giulieri SG;Baines SL;Guerillot R;Seemann T;Gonçalves da Silva A;Schultz M;Massey RC;Holmes NE;Stinear TP;Howden BP; (2018) 'Genomic exploration of sequential clinical isolates reveals a distinctive molecular signature of persistent Staphylococcus aureus bacteraemia'. Genome Medicine, 10 (1) [DOI] [Details] | |
(2018) | 'Disease-associated genotypes of the commensal skin bacterium Staphylococcus epidermidis' Méric G;Mageiros L;Pensar J;Laabei M;Yahara K;Pascoe B;Kittiwan N;Tadee P;Post V;Lamble S;Bowden R;Bray JE;Morgenstern M;Jolley KA;Maiden MCJ;Feil EJ;Didelot X;Miragaia M;de Lencastre H;Moriarty TF;Rohde H;Massey R;Mack D;Corander J;Sheppard SK; (2018) 'Disease-associated genotypes of the commensal skin bacterium Staphylococcus epidermidis'. Nature Communications, 9 (1) [DOI] [Details] | |
(2017) | 'Clonal differences in Staphylococcus aureus bacteraemia-associated mortality' Recker M;Laabei M;Toleman MS;Reuter S;Saunderson RB;Blane B;Török ME;Ouadi K;Stevens E;Yokoyama M;Steventon J;Thompson L;Milne G;Bayliss S;Bacon L;Peacock SJ;Massey RC; (2017) 'Clonal differences in Staphylococcus aureus bacteraemia-associated mortality'. Nature Microbiology, 2 (10) [DOI] [Details] | |
(2017) | 'Bacterial toxins: Offensive, defensive, or something else altogether?' Rudkin, Justine K.; McLoughlin, Rachel M.; Preston, Andrew; Massey, Ruth C. (2017) 'Bacterial toxins: Offensive, defensive, or something else altogether?'. Plos Pathogens, 13 (9) [DOI] [Full Text] [Details] | |
(2017) | 'Cytolytic toxin production by Staphylococcus aureus is dependent upon the activity of the protoheme IX farnesyltransferase' Stevens E;Laabei M;Gardner S;Somerville GA;Massey RC; (2017) 'Cytolytic toxin production by Staphylococcus aureus is dependent upon the activity of the protoheme IX farnesyltransferase'. Scientific Reports, 7 (1) [DOI] [Details] | |
(2017) | 'Promiscuous bacteria have staying power' Massey RC;Wilson DJ; (2017) 'Promiscuous bacteria have staying power'. Elife, 6 [DOI] [Details] | |
(2017) | 'Severe infections emerge from commensal bacteria by adaptive evolution' Young BC;Wu CH;Gordon NC;Cole K;Price JR;Liu E;Sheppard AE;Perera S;Charlesworth J;Golubchik T;Iqbal Z;Bowden R;Massey RC;Paul J;Crook DW;Peto TE;Walker AS;Llewelyn MJ;Wyllie DH;Wilson DJ; (2017) 'Severe infections emerge from commensal bacteria by adaptive evolution'. Elife, 6 [DOI] [Details] | |
(2016) | 'Natural mutations in a Staphylococcus aureus virulence regulator attenuate cytotoxicity but permit bacteremia and abscess formation' Das S;Lindemann C;Young BC;Muller J;Österreich B;Ternette N;Winkler AC;Paprotka K;Reinhardt R;Förstner KU;Allen E;Flaxman A;Yamaguchi Y;Rollier CS;van Diemen P;Blättner S;Remmele CW;Selle M;Dittrich M;Müller T;Vogel J;Ohlsen K;Crook DW;Massey R;Wilson DJ;Rudel T;Wyllie DH;Fraunholz MJ; (2016) 'Natural mutations in a Staphylococcus aureus virulence regulator attenuate cytotoxicity but permit bacteremia and abscess formation'. Proceedings of The National Academy of Sciences of The United States of America, 113 (22) [DOI] [Details] | |
(2016) | 'Using functional genomics to decipher the complexity of microbial pathogenicity' Laabei M;Massey R; (2016) 'Using functional genomics to decipher the complexity of microbial pathogenicity'. Current Genetics, 62 (3) [DOI] [Details] | |
(2015) | 'Evolutionary Trade-Offs Underlie the Multi-faceted Virulence of Staphylococcus aureus' Laabei M;Uhlemann AC;Lowy FD;Austin ED;Yokoyama M;Ouadi K;Feil E;Thorpe HA;Williams B;Perkins M;Peacock SJ;Clarke SR;Dordel J;Holden M;Votintseva AA;Bowden R;Crook DW;Young BC;Wilson DJ;Recker M;Massey RC; (2015) 'Evolutionary Trade-Offs Underlie the Multi-faceted Virulence of Staphylococcus aureus'. PloS Biology, 13 (9) [DOI] [Details] | |
(2015) | 'Manipulation of Autophagy in Phagocytes Facilitates Staphylococcus aureus Bloodstream Infection' O'Keeffe KM;Wilk MM;Leech JM;Murphy AG;Laabei M;Monk IR;Massey RC;Lindsay JA;Foster TJ;Geoghegan JA;McLoughlin RM; (2015) 'Manipulation of Autophagy in Phagocytes Facilitates Staphylococcus aureus Bloodstream Infection'. Infection and Immunity, 83 (9) [DOI] [Details] | |
(2014) | 'Evidence for steric regulation of fibrinogen binding to Staphylococcus aureus fibronectin-binding protein A (FnBPA)' Stemberk V;Jones RP;Moroz O;Atkin KE;Edwards AM;Turkenburg JP;Leech AP;Massey RC;Potts JR; (2014) 'Evidence for steric regulation of fibrinogen binding to Staphylococcus aureus fibronectin-binding protein A (FnBPA)'. Journal of Biological Chemistry, 289 (18) [DOI] [Details] | |
(2014) | 'Staphylococcus aureus interaction with phospholipid vesicles--a new method to accurately determine accessory gene regulator (agr) activity' Laabei M;Jamieson WD;Massey RC;Jenkins AT; (2014) 'Staphylococcus aureus interaction with phospholipid vesicles--a new method to accurately determine accessory gene regulator (agr) activity'. Plos One, 9 (1) [DOI] [Details] | |
(2014) | 'Predicting the virulence of MRSA from its genome sequence' Laabei M;Recker M;Rudkin JK;Aldeljawi M;Gulay Z;Sloan TJ;Williams P;Endres JL;Bayles KW;Fey PD;Yajjala VK;Widhelm T;Hawkins E;Lewis K;Parfett S;Scowen L;Peacock SJ;Holden M;Wilson D;Read TD;van den Elsen J;Priest NK;Feil EJ;Hurst LD;Josefsson E;Massey RC; (2014) 'Predicting the virulence of MRSA from its genome sequence'. Genome Research, 24 (5) [DOI] [Details] | |
(2014) | 'Oxacillin alters the toxin expression profile of community-associated methicillin-resistant Staphylococcus aureus' Rudkin JK;Laabei M;Edwards AM;Joo HS;Otto M;Lennon KL;O'Gara JP;Waterfield NR;Massey RC; (2014) 'Oxacillin alters the toxin expression profile of community-associated methicillin-resistant Staphylococcus aureus'. Antimicrobial Agents and Chemotherapy, 58 (2) [DOI] [Details] | |
(2014) | 'Characterizing the genetic basis of bacterial phenotypes using genome-wide association studies: a new direction for bacteriology' Read TD;Massey RC; (2014) 'Characterizing the genetic basis of bacterial phenotypes using genome-wide association studies: a new direction for bacteriology'. Genome Medicine, 6 (11) [DOI] [Details] | |
(2012) | 'Staphylococcus aureus extracellular adherence protein triggers TNFa release, promoting attachment to endothelial cells via protein A' Edwards AM;Bowden MG;Brown EL;Laabei M;Massey RC; (2012) 'Staphylococcus aureus extracellular adherence protein triggers TNFa release, promoting attachment to endothelial cells via protein A'. Plos One, 7 (8) [DOI] [Details] | |
(2012) | 'Molecular mechanisms of Staphylococcus aureus nasopharyngeal colonization' Edwards AM;Massey RC;Clarke SR; (2012) 'Molecular mechanisms of Staphylococcus aureus nasopharyngeal colonization'. Molecular Oral Microbiology, 27 (1) [DOI] [Details] | |
(2012) | 'Methicillin resistance reduces the virulence of healthcare-associated methicillin-resistant Staphylococcus aureus by interfering with the agr quorum sensing system' Rudkin JK;Edwards AM;Bowden MG;Brown EL;Pozzi C;Waters EM;Chan WC;Williams P;O'Gara JP;Massey RC; (2012) 'Methicillin resistance reduces the virulence of healthcare-associated methicillin-resistant Staphylococcus aureus by interfering with the agr quorum sensing system'. Journal of Infectious Diseases, 205 (5) [DOI] [Details] | |
(2012) | 'Methicillin resistance alters the biofilm phenotype and attenuates virulence in Staphylococcus aureus device-associated infections' Pozzi C;Waters EM;Rudkin JK;Schaeffer CR;Lohan AJ;Tong P;Loftus BJ;Pier GB;Fey PD;Massey RC;O'Gara JP; (2012) 'Methicillin resistance alters the biofilm phenotype and attenuates virulence in Staphylococcus aureus device-associated infections'. Plos Pathogens, 8 (4) [DOI] [Details] | |
(2011) | 'Invasion of human cells by a bacterial pathogen' Edwards AM;Massey RC; (2011) 'Invasion of human cells by a bacterial pathogen'. Journal of visualized experiments : JoVE, (49) [DOI] [Details] | |
(2011) | 'How does Staphylococcus aureus escape the bloodstream?' Edwards AM;Massey RC; (2011) 'How does Staphylococcus aureus escape the bloodstream?'. Trends In Microbiology, 19 (4) [DOI] [Details] | |
(2011) | 'Staphylococcus aureus keratinocyte invasion is dependent upon multiple high-affinity fibronectin-binding repeats within FnBPA' Edwards AM;Potter U;Meenan NA;Potts JR;Massey RC; (2011) 'Staphylococcus aureus keratinocyte invasion is dependent upon multiple high-affinity fibronectin-binding repeats within FnBPA'. Plos One, 6 (4) [DOI] [Details] | |
(2010) | 'Offsetting virulence and antibiotic resistance costs by MRSA' Collins J;Rudkin J;Recker M;Pozzi C;O'Gara JP;Massey RC; (2010) 'Offsetting virulence and antibiotic resistance costs by MRSA'. ISME Journal, 4 (4) [DOI] [Details] | |
(2010) | 'Staphylococcus aureus host cell invasion and virulence in sepsis is facilitated by the multiple repeats within FnBPA' Edwards AM;Potts JR;Josefsson E;Massey RC; (2010) 'Staphylococcus aureus host cell invasion and virulence in sepsis is facilitated by the multiple repeats within FnBPA'. Plos Pathogens, 6 (6) [DOI] [Details] | |
(2008) | 'Identification of factors contributing to T-cell toxicity of Staphylococcus aureus clinical isolates' Collins J;Buckling A;Massey RC; (2008) 'Identification of factors contributing to T-cell toxicity of Staphylococcus aureus clinical isolates'. Journal of Clinical Microbiology, 46 (6) [DOI] [Details] | |
(2008) | 'The Staphyloccous aureus Eap protein activates expression of proinflammatory cytokines' Scriba TJ;Sierro S;Brown EL;Phillips RE;Sewell AK;Massey RC; (2008) 'The Staphyloccous aureus Eap protein activates expression of proinflammatory cytokines'. Infection and Immunity, 76 (5) [DOI] [Details] | |
(2008) | 'Interspecific competition and siderophore-mediated cooperation in Pseudomonas aeruginosa' Harrison F;Paul J;Massey RC;Buckling A; (2008) 'Interspecific competition and siderophore-mediated cooperation in Pseudomonas aeruginosa'. ISME Journal, 2 (1) [DOI] [Details] | |
(2007) | 'Use of peptide-major histocompatibility complex tetramer technology to study interactions between Staphylococcus aureus proteins and human cells' Massey RC;Scriba TJ;Brown EL;Phillips RE;Sewell AK; (2007) 'Use of peptide-major histocompatibility complex tetramer technology to study interactions between Staphylococcus aureus proteins and human cells'. Infection and Immunity, 75 (12) [DOI] [Details] | |
(2006) | 'Agr interference between clinical Staphylococcus aureus strains in an insect model of virulence' Fleming V;Feil E;Sewell AK;Day N;Buckling A;Massey RC; (2006) 'Agr interference between clinical Staphylococcus aureus strains in an insect model of virulence'. Journal of Bacteriology, 188 (21) [DOI] [Details] | |
(2006) | 'Antagonistic coevolution with parasites increases the cost of host deleterious mutations' Buckling A;Wei Y;Massey RC;Brockhurst MA;Hochberg ME; (2006) 'Antagonistic coevolution with parasites increases the cost of host deleterious mutations'. Proceedings of The Royal Society B-Biological Sciences, 273 (1582) [DOI] [Details] | |
(2006) | 'The evolution and maintenance of virulence in Staphylococcus aureus: a role for host-to-host transmission?' Massey RC;Horsburgh MJ;Lina G;Höök M;Recker M; (2006) 'The evolution and maintenance of virulence in Staphylococcus aureus: a role for host-to-host transmission?'. Nature Reviews. Microbiology, 4 (12) [DOI] [Details] | |
(2005) | 'Clonal distribution and phase-variable expression of a major histocompatibility complex analogue protein in Staphylococcus aureus' Buckling A;Neilson J;Lindsay J;ffrench-Constant R;Enright M;Day N;Massey RC; (2005) 'Clonal distribution and phase-variable expression of a major histocompatibility complex analogue protein in Staphylococcus aureus'. Journal of Bacteriology, 187 (8) [DOI] [Details] | |
(2005) | 'Clonal distribution and phase-variable expression of a major histocompatibility complex analogue protein in Staphylococcus aureus' Buckling A;Neilson J;Lindsay J;ffrench-Constant R;Enright M;Day N;Massey RC; (2005) 'Clonal distribution and phase-variable expression of a major histocompatibility complex analogue protein in Staphylococcus aureus'. Journal of Bacteriology, 187 (8) [DOI] [Details] | |
(2004) | 'Interference competition and parasite virulence' Massey RC;Buckling A;ffrench-Constant R; (2004) 'Interference competition and parasite virulence'. Proceedings of The Royal Society B-Biological Sciences, 271 (1541) [DOI] [Details] | |
(2004) | 'Clumping factor B, a fibrinogen-binding MSCRAMM (microbial surface components recognizing adhesive matrix molecules) adhesin of Staphylococcus aureus, also binds to the tail region of type I cytokeratin 10' Walsh EJ;O'Brien LM;Liang X;Hook M;Foster TJ; (2004) 'Clumping factor B, a fibrinogen-binding MSCRAMM (microbial surface components recognizing adhesive matrix molecules) adhesin of Staphylococcus aureus, also binds to the tail region of type I cytokeratin 10'. Journal of Biological Chemistry, 279 (49) [DOI] [Details] | |
(2003) | 'Characterization of novel LPXTG-containing proteins of Staphylococcus aureus identified from genome sequences' Roche FM;Massey R;Peacock SJ;Day NPJ;Visai L;Speziale P;Lam A;Pallen M;Foster TJ; (2003) 'Characterization of novel LPXTG-containing proteins of Staphylococcus aureus identified from genome sequences'. Microbiology-SGM, 149 (Pt 3) [DOI] [Details] | |
(2003) | 'Genes encoding a cellulosic polymer contribute toward the ecological success of Pseudomonas fluorescens SBW25 on plant surfaces' Gal M;Preston GM;Massey RC;Spiers AJ;Rainey PB; (2003) 'Genes encoding a cellulosic polymer contribute toward the ecological success of Pseudomonas fluorescens SBW25 on plant surfaces'. Molecular Ecology, 12 (11) [DOI] [Details] | |
(2002) | 'The ica operon and biofilm production in coagulase-negative Staphylococci associated with carriage and disease in a neonatal intensive care unit' de Silva GD;Kantzanou M;Justice A;Massey RC;Wilkinson AR;Day NP;Peacock SJ; (2002) 'The ica operon and biofilm production in coagulase-negative Staphylococci associated with carriage and disease in a neonatal intensive care unit'. Journal of Clinical Microbiology, 40 (2) [DOI] [Details] | |
(2002) | 'Antibiotic-resistant sub-populations of the pathogenic bacterium Staphylococcus aureus confer population-wide resistance' Massey RC;Peacock SJ; (2002) 'Antibiotic-resistant sub-populations of the pathogenic bacterium Staphylococcus aureus confer population-wide resistance'. Current Biology, 12 (20) [DOI] [Details] | |
(2002) | 'Environmental regulation of mutation rates at specific sites' Massey RC;Buckling A; (2002) 'Environmental regulation of mutation rates at specific sites'. Trends In Microbiology, 10 (12) [DOI] [Details] | |
(2002) | 'Staphylococcus aureus clumping factor B (ClfB) promotes adherence to human type I cytokeratin 10: implications for nasal colonization' O'Brien LM;Walsh EJ;Massey RC;Peacock SJ;Foster TJ; (2002) 'Staphylococcus aureus clumping factor B (ClfB) promotes adherence to human type I cytokeratin 10: implications for nasal colonization'. Cellular Microbiology, 4 (11) [DOI] [Details] | |
(2002) | 'Functional blocking of Staphylococcus aureus adhesins following growth in ex vivo media' Massey RC;Dissanayeke SR;Cameron B;Ferguson D;Foster TJ;Peacock SJ; (2002) 'Functional blocking of Staphylococcus aureus adhesins following growth in ex vivo media'. Infection and Immunity, 70 (10) [DOI] [Details] | |
(2001) | 'Fibronectin-binding protein A of Staphylococcus aureus has multiple, substituting, binding regions that mediate adherence to fibronectin and invasion of endothelial cells' Massey RC;Kantzanou MN;Fowler T;Day NP;Schofield K;Wann ER;Berendt AR;Höök M;Peacock SJ; (2001) 'Fibronectin-binding protein A of Staphylococcus aureus has multiple, substituting, binding regions that mediate adherence to fibronectin and invasion of endothelial cells'. Cellular Microbiology, 3 (12) [DOI] [Details] | |
(2001) | 'Phenotypic switching of antibiotic resistance circumvents permanent costs in Staphylococcus aureus' Massey RC;Buckling A;Peacock SJ; (2001) 'Phenotypic switching of antibiotic resistance circumvents permanent costs in Staphylococcus aureus'. Current Biology, 11 (22) [DOI] [Details] | |
(2000) | 'The virulence plasmid of Salmonella typhimurium contains an autoregulated gene, rlgA, that codes for a resolvase-like DNA binding protein' Massey RC;Bowe F;Sheehan BJ;Dougan G;Dorman CJ; (2000) 'The virulence plasmid of Salmonella typhimurium contains an autoregulated gene, rlgA, that codes for a resolvase-like DNA binding protein'. Plasmid, 44 (1) [DOI] [Details] | |
(1999) | 'Environmentally constrained mutation and adaptive evolution in Salmonella' Massey RC;Rainey PB;Sheehan BJ;Keane OM;Dorman CJ; (1999) 'Environmentally constrained mutation and adaptive evolution in Salmonella'. Current Biology, 9 (24) [DOI] [Details] |
Reviews
Year | Publication | |
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(2012) | From genotype to phenotype: can systems biology be used to predict Staphylococcus aureus virulence?. Priest NK;Rudkin JK;Feil EJ;van den Elsen JM;Cheung A;Peacock SJ;Laabei M;Lucks DA;Recker M;Massey RC; (2012) From genotype to phenotype: can systems biology be used to predict Staphylococcus aureus virulence?. Reviews [DOI] [Details] |
Professional Activities
Honours and Awards
Year | Title | Awarding Body | |
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2023 | Elected Member EMBO | European Molecular Biology Organization (EMBO) |