Research Profile

Biography

                         

Humphrey Moynihan is Senior Lecturer in Organic Chemistry (Pharmaceutical/Medicinal) in the Dept. of Chemistry, UCC, and is also a PI in the Analytical and Biological Chemistry Research Facility, UCC.  He received BSc and PhD degrees from UCC and carried out postdoctoral research at the Universities of Exeter and Bristol before joining Liverpool John Moores University in 1994 as Lecturer in Organic Chemistry.  He returned to UCC in 2002.

Dr. Moynihan carried out PhD research in heterocyclic synthesis (under Dr. D. G. McCarthy) and postdoctoral work on the medicinal chemistry of vasodilators (with Prof. S. M. Roberts) and opioids (Dr. J. W. Lewis).  He recognised the importance of physical properties in the manufacturing and formulation of pharmaceuticals and bio-active chemicals, especially of solid state properties such as crystal polymorphism, crystallisation process design, crystal morphology and size distribution.  Based on this, he developed research programmes which interfaced synthetic organic chemistry with crystallisation and crystal chemistry.  Often, this research is in collaboration with Dr. S. E. Lawrence in the area of crystallography.  The strategic importance of the organic chemistry / solid state interface developed by Dr. Moynihan is evidenced by a series of significant research funding awards, especially the following:

-SFI Research Centre funding (the Synthesis and Solid-state Pharmaceutical Centre, commenced 2013, in collaboration with UL [Prof. B. K. Hodnett], NUIG, TCD, UCD and several pharmaceutical companies) Total award >€20M (>4M to UCC)

-SFI Strategic Research Cluster funding (the Solid State Pharmaceutical Cluster 2008-2012; in collaboration with UL, NUIG, TCD, UCD and nine PharmaChemical companies). Total award > €5M (>€1M to UCC)

-FP6 Marie Curie Transfer of Knowledge funding (Developing Expertise in Pharmaceutical Materials and Biomaterials) €500K

Dr. Moynihan has participated in securing €7.7M of research funding for UCC, of which >€6M was since 2008. 

Examples of Dr. Moynihan's research include development of highly efficient crystallisation additives [CrystEngComm, 2007, 9, 72-77] and crystal engineering of functionalised carbohydrates [Carbohydr. Res., 2014, 388, 67-72.], as well as collaborative research in analytical chemistry [Electrochimica Acta, 2009, 54, 1919-1924] and medicinal chemistry [J. Med. Chem., 2012, 55, 9868-6874.].

He has over 50 peer reviewed publications (20 since 2008) in journals such as Crystal Growth & Design, CrystEngComm, Journal of Medicinal Chemistry and Carbohydrate Research.  His h-index is currently 12.  He has one patent and one licensing agreement, in the area of crystal polymorphs of commercial pigments.  He has received awards from Enterprise Ireland and UCC for research commercialisation.  He has successfully supervised 14 postgraduate students and 7 postdoctoral researchers.  A key aspect of his postgraduate supervision is the development of skills in both synthetic chemistry and solid state issues such as polymorphism, crystal habit and particle size distribution.

Dr. Moynihan is Coordinator of the BSc Chemistry of Pharmaceutical Compound degree and has developed new research-inspired undergraduate modules in Pharmaceutical Solids and Technology (CM3110 with Dr. S. E. Lawrence) and the Physicochemical Basis of Pharmaceuticals (PF1010 with Dr. A. Crean).  He has served as an undergraduate External Examiner at Liverpool John Moores University (Chemistry modules on the ACAPS Programme) and as postgraduate External Examiner in the Universities of Bristol, Bath and DCU. 


Research Interests

Crystallisation and crystal chemistry of organic compounds. Also medicinal, organic and analytical chemistry.

Most pharmaceuticals, foodstuffs and fine chemicals are crystalline solids in their pure forms. Crystallization provides a method of isolating pure compounds in a convenient physical form. Many compounds crystallize in more than one form, i.e. crystal polymorphs and solvates. Crystals can also differ in their shape (morphology, habit), size and size distribution. Controlling crystal form and morphology is very important for pharmaceuticals, foods, pigments and many other high-value fine chemicals.

Dr. Moynihan's research into crystallisation and crystal chemistry of organic includes crystal engineering, crystallisation method development and crystal nucleation studies. The research is often in collaboration with Dr. Simon Lawrence and Prof. Anita Maguire.

Major grant awards for this team include:

-SFI Research Centre funding (Synthesis and Solid-state Pharmaceutical Centre, commenced 2013, in collaboration with UL [Prof. B. K. Hodnett], NUIG, TCD, UCD and several pharmaceutical companies) Total award >€20M

-SFI Strategic Research Cluster funding (Solid State Pharmaceutical Cluster 2008-2012; in collaboration with UL, NUIG, TCD, UCD and nine PharmaChemical companies). Total award > €5M

-FP6 Marie Curie Transfer of Knowledge funding (DEPMaB) €500K

-SFI UREKA Site funding, €250M

-Enterprise Ireland Commercialisation Fund Proof of Concept awards >€100K

-IRCSET and other awards.

Specific projects and selected outputs include:

-Research into 'tailor-made' additives for the control of crystal polymorphism:

[Monomeric and polymeric derivatives of 5-aminoisophthalic acid as selective inhibitors of the beta-polymorph of L-glutamic acid, Joanne M. Kelleher, Simon E. Lawrence, Marie T. McAuliffe and Humphrey A. Moynihan, CrystEngComm, 2007, 9(1), 72-77.]

-Crystal engineering with functionalised sugars:

[Supramolecular stacking motifs in the solid state of amide and triazole derivatives of cellobiose, John A. Hayes, Kevin S. Eccles, Simon J. Coles, Simon E. Lawrence, Humphrey A. Moynihan, Carbohydrate Research, 2014, 388, 67-72.]

-Crystallisation process development:

[Humphrey A. Moynihan and Dawn M. Kelly (September 2012). Phenacetin Crystallization: Cooling Regimes and Crystal Morphology, Crystallization - Science and Technology, Marcello Rubens Barsi Andreeta (Ed.), ISBN: 978-953-51-0757-6, InTech]

Since 2002, 7 postgraduate students have obtained PhDs in molecular crystallisation research in my group and are now working in the pharmaceutical industry. 4 Postdoctoral reserchers have worked on these projects.

Other research interests include:

-Synthetic organic chemistry:

[Cyclisations of Benzenesulfanyl Chloride Adducts with Conjugated Silyloxyenones: A New Stereoselective Reaction in the Synthesis of 4,5-Dihydro-3(2H)-Furanones,  Conor C. Collins, Michael F. Cronin, Humphrey A. Moynihan and Daniel G. McCarthy, J. Chem. Soc., Perkin Transactions 1, 1997, 1267 – 1269]

-Medicinal chemistry:

[Fumaroylamino-4,5-epoxymorphinans and Related Opioids with Irreversible m Opioid Receptor Antagonist Effects, Humphrey A. Moynihan, Ian Derrick, Jillian H. Broadbear, Benjamin M. Greedy, Mario D. Aceto, Louis S. Harris, Lauren C. S. Purington, Mark P. Thomas, James H. Woods, John R. Traynor, Stephen M. Husbands, and John W. Lewis, J. Med. Chem., 2012, 55, 9868-6874]

-Analytical chemistry:

[“Spin-Labelling with the Second Hydrogen Radioisotope: Radicals Formed from Squalene by Muonium Addition, Christopher J. Rhodes, Timothy C. Dintinger, Humphrey A. Moynihan and Ivan D. Reid, Free Radical Research, 2000, 33, 75-79; Electrochemistry of dopamine at the polarised liquid/liquid facilitated by an homo-oxo-calix[3]arene ionophore, Grégoire Herzog, Brian McMahon, Myriam Lefoix, Nicholas D. Mullins, Courtney J. Collins, Humphrey A. Moynihan, Damien W. M. Arrigan, J. Electroanal. Chem. 2008, 622(1), 109-114.]

8 Postgraduate students and 4 postdoctoral researchers have worked on these projects.

Research funding active or awarded since 2008

May 2005; Polymorph-selective crystal nucleation inhibition using dendritic 'tailor-made' additives; Irish Research Council for Science, Engineering and Technology EMBARK Postgraduate Scholarships, H. A. Moynihan (PI) and A. L. Ryan; Postgraduate Support; €57,150; €12,002 (6 Month’s Extension Oct 2008)

August 2005; Developing Expertise in Pharmaceutical Materials and Biomaterials (DEPMaB); L. Addadi (Weizmann Institute of Science, Israel), A. M. Crean (UCC), W. Jiskoot (University of Leiden, The Netherlands), M. Lahav (Weizmann Institute of Science, Israel), S. E. Lawrence (UCC), A. R. Maguire (UCC), H. A. Moynihan (UCC, Co-ordinator), C. M. O'Driscoll (UCC); EU Framework Programme 6 Human Resources and Mobility Actions Marie Curie Fellowships for Transfer of Knowledge – Development; Postdoctoral Fellowships and Placements; Contract No. MTKD-CT-2005-029896; €526,873

October 2005; Development of an ion flux generator as an alternative neuro stimulator - Work Package 2; J. Alderman, D. W. M. Arrigan, H. A. Moynihan (collaborator on synthesis), T. Wood, N. MacCarthy; Enterprise Ireland Commercialisation Fund 2005 Technology Development Phase; Postdoctoral Support; (Work Package 2- H. A. Moynihan & PDRA), €75,000

May 2006; Probing and controlling crystal nucleation in aqueous media; Irish Research Council for Science, Engineering and Technology EMBARK Postgraduate Scholarships; H. A. Moynihan (PI) and D. M. Kelly; Postgraduate Support; €72,009

January 2007;  Undergraduate PharmaChemical Research Opportunities; Science Foundation Ireland Undergraduate Research Experience and Knowledge Awards (UREKA) Sites [07/UR/B1077]; D. W. M. Arrigan, A. M. Crean, J. D. Glennon, B. Griffin, W. B. Jennings, J. J. Keating, S. E. Lawrence, A. R. Maguire, D. G. McCarthy, F. O. McCarthy, H. A. Moynihan (co-PI), O. M. Ni Dhubhghaill, C. M. O'Driscoll; Undergraduate Summer Research Studentships; €235,800

October 2007; Obtaining commercial metastable forms by crystal engineering: Pigment Blue 15:0; H. A. Moynihan (PI); Enterprise Ireland Commercialisation Fund - Proof of Concept Phase 2007 [PC/2007/129]; Postdoctoral Support; €83,426

October 2007; Hydrogen-bond patterns and crystal polymorphism: identifying and exploiting differences; Irish Research Council for Science, Engineering and Technology EMBARK Postgraduate Scholarships; H. A. Moynihan (PI) and R. J. Austin; Postgraduate Support; €72,009

November 2007; Solid State Pharmaceutical Cluster; Science Foundation Ireland Strategic Research Clusters [07/SRC/B1158]; O. I. Corrigan (TCD), A. Crean (UCC), B. Glennon (UCD), A.-M. Healy (TCD), B. K. Hodnett (UL, Lead PI), S. E. Lawrence (UCC), A. R. Maguire (UCC), P. McArdle (NUIG), H. A. Moynihan (UCC, UCC Lead PI); Nine PharmaChemical Companies; Postgraduate, postdoctoral and equipment funding; Total Award €7M; UCC Portion: €1,470,033

November 2009; Powder Diffraction of Pharmaceutical Cocrystals; Science Foundation Ireland Technology and Innovation Development Award Programme 2009 [05/PICA/B802 TIDA 09]; A. R. Maguire, S. E. Lawrence, H. A. Moynihan (co-PI), Almac Sciences (N. Hamill & L. McCausland); Postdoctoral support; €73,800

February 2010; Optimized crystal morphologies for active pharmaceutical ingredients; Irish Research Council for Science, Engineering and Technology Enterprise Partnership Scheme & Clarochem Ireland Limited; H. A. Moynihan (PI) and Danielle Horgan; Postgraduate support; €72,009

November 2010; Gentamicin degradation and release of coated surfaces; Enterprise Ireland Innovation Partnership Programme 2010, A. R. Maguire, H. A. Moynihan (co-PI), S. E. Lawrence, F. O.McCarthy, A. M. Crean, Depuy (Ireland) Ltd.; IP-2010-0068 from September 2011 – August 2013 €249,193

February 2013; Synthesis and Solid-state Pharmaceutical Centre; Science Foundation Ireland Research Centres; B. K. Hodnett (UL), P. Frawley (UL), K. Ryan (UL), E. Magner (UL), Å Rasmuson (UL), G. Walker (UL) A. Erxleben (NUIG), A. Ryder (NUIG), P. McArdle (NUIG), S. J. Connon (TCD), A. M. Healy (TCD), L. Tajber (TCD), B. Glennon (UCD), P. Guiry (UCD), M. Albrecht (UCD), D. Gilheany (UCD), N. Gathergood (DCU), A. R. Maguire (UCC), A. Crean (UCC), G. P. McGlacken (UCC), S. E. Lawrence (UCC), H. A. Moynihan, (UCC, co-FI), A. Dobson (UCC), F. O'Gara (UCC); 13 Pharmaceutical and related companies; Postdoctoral and postgraduate support; equipment; Total award: €22M (UCC portion: €4,393,451)

 Smaller awards include IP and grant preparation support and contract research projects for industry.

 





Publications

Peer Reviewed Journals

 YearPublication
(2019)'Stepwise dissolution and composition determination of samples of multiple crystals using a dissolution medium containing aqueous alcohol and fluorocarbon phases'
Moynihan H.;Armstrong D. (2019) 'Stepwise dissolution and composition determination of samples of multiple crystals using a dissolution medium containing aqueous alcohol and fluorocarbon phases'. RSC Advances, 9 (37):21405-21417 [DOI] [Full Text] [Details]
(2018)'Determination of composition distributions of multi-particle crystalline samples by sequential dissolution with concomitant particle sizing and solution analysis'
Moynihan, Humphrey A.; Armstrong, Declan (2018) 'Determination of composition distributions of multi-particle crystalline samples by sequential dissolution with concomitant particle sizing and solution analysis'. CrystEngComm, 20 :2617-2633   [DOI] [Full Text] [Details]
(2017)'Impurity occurrence and removal in crystalline products from process reactions'
Moynihan, Humphrey A.; Horgan, Danielle E. (2017) 'Impurity occurrence and removal in crystalline products from process reactions'. Organic Process Research & Development, 21 (5):689-704 [DOI] [Full Text] [Details]
(2016)'The impact of storage conditions upon gentamicin coated antimicrobial implant'
Nicholas D. Mullins, Benjamin J. Deadman, Humphrey A. Moynihan, Florence O. McCarthy, Simon E. Lawrence, Jonathan Thompson, Anita R. Maguire (2016) 'The impact of storage conditions upon gentamicin coated antimicrobial implant'. Journal Of Pharmaceutical Analysis, 6 (6):374-381 [Details]
(2016)'Methyl tetra-O-acetyl-α-D-glucopyranuronate: crystal structure and influence on the crystallization of the beta anomer'
John A. Hayes, Kevin S. Eccles, Simon E. Lawrence, Humphrey A. Moynihan (2016) 'Methyl tetra-O-acetyl-α-D-glucopyranuronate: crystal structure and influence on the crystallization of the beta anomer'. Carbohydrate Research, 425 :35-39 [DOI] [Full Text] [Details]
(2016)'Development of a continuous process for α-thio-β-chloroacrylamide synthesis with enhanced control of a cascade transformation'
Dennehy, O.C.; Cacheux, V.M.Y.; Deadman, B.J.; Lynch, D.; Collins, S.G.; Moynihan, H.A.; Maguire, A.R. (2016) 'Development of a continuous process for α-thio-β-chloroacrylamide synthesis with enhanced control of a cascade transformation'. Beilstein Journal Of Organic Chemistrybeilstein Journal Of Organic Chemistry, 12 :2511-2522 [DOI] [Full Text] [Details]
(2015)'Demonstrating the influence of solvent choice and crystallization conditions on phenacetin crystal habit and particle size distribution'
Croker, Denise; Kelly, Dawn M.; Hodnett, Benjamin K.; Lawrence, Simon E.; Horgan, Danielle E.; Moynihan, Humphrey A..; Rasmusson, Ake (2015) 'Demonstrating the influence of solvent choice and crystallization conditions on phenacetin crystal habit and particle size distribution'. Organic Process Research & Development, 19 (12):1826-1836 [DOI] [Details]
(2014)'Supramolecular stacking motifs in the solid state of amide and triazole derivatives of cellobiose'
John A. Hayes, Kevin S. Eccles, Simon J. Coles, Simon E. Lawrence, Humphrey A. Moynihan (2014) 'Supramolecular stacking motifs in the solid state of amide and triazole derivatives of cellobiose'. Carbohydrate Research, 388 :67-72 [Full Text] [Details]
(2013)'Hydrogen bonding in crystal forms of primary amide functionalized glucose and cellobiose'
Humphrey A. Moynihan, John A. Hayes, Kevin S. Eccles, Simon J. Coles, Simon E. Lawrence (2013) 'Hydrogen bonding in crystal forms of primary amide functionalized glucose and cellobiose'. Carbohydrate Research, 374 :29-39 [Full Text] [Details]
(2013)'Crystal Polymorphism of Methyl 2,3,4-tri-O-acetyl-1-O-(trichloroacetimidoyl)-α-d-glucopyranouronate'
John A. Hayes, Kevin S. Eccles, Curtis J. Elcoate, Carla A. Daly, Simon E. Lawrence and Humphrey A. Moynihan (2013) 'Crystal Polymorphism of Methyl 2,3,4-tri-O-acetyl-1-O-(trichloroacetimidoyl)-α-d-glucopyranouronate'. Journal Of Chemical Crystallography, 43 (3):138-143 [DOI] [Full Text] [Details]
(2012)'Fumaroylamino-4,5-epoxymorphinans and Related Opioids with Irreversible mu Opioid Receptor Antagonist Effects'
Humphrey A. Moynihan, Ian Derrick, Jillian H. Broadbear, Benjamin M. Greedy, Mario D. Aceto, Louis S. Harris, Lauren C. S. Purington, Mark P. Thomas, James H. Woods, John R. Traynor, Stephen M. Husbands, and John W. Lewis (2012) 'Fumaroylamino-4,5-epoxymorphinans and Related Opioids with Irreversible mu Opioid Receptor Antagonist Effects'. Journal of Medicinal Chemistry, 55 :9868-9874 [Details]
(2012)'Preparation and characterisation of solid state forms of paracetamol-O-glucuronide'
John A. Hayes, Kevin S. Eccles, Simon E. Lawrence, Humphrey A. Moynihan (2012) 'Preparation and characterisation of solid state forms of paracetamol-O-glucuronide'. Carbohydrate Research, 349 :108-112 [Full Text] [Details]
(2012)'Utilizing Sulfoxide...Iodine Halogen Bonding for Cocrystallization'
Eccles, Kevin; Morrison, Robin; Stokes, Stephen; O'Mahony, Graham; Hayes, John; Kelly, Dawn; O'Boyle, Noel; Fabian, Laszlo; Moynihan, H.; Maguire, Anita; Lawrence, Simon E. (2012) 'Utilizing Sulfoxide...Iodine Halogen Bonding for Cocrystallization'. Crystal Growth and Design, 12 (6):2969-2977 [Full Text] [Details]
(2011)'Cocrystals of fenamic acids with nicotinamide'
Fabian, Laszlo; Hamill, Noel; Eccles, Kevin; Moynihan, H.; Maguire, Anita; McCausland, Linda; Lawrence, Simon E; (2011) 'Cocrystals of fenamic acids with nicotinamide'. Crystal Growth and Design, 11 :3522-3528 [DOI] [Full Text] [Details]
(2011)'Evaluation of the Bruker SMART X2S: crystallography for the nonspecialist?'
Eccles, KS,Stokes, SP,Daly, CA,Barry, NM,McSweeney, SP,O'Neill, DJ,Kelly, DM,Jennings, WB,Dhubhghaill, OMN,Moynihan, HA,Maguire, AR,Lawrence, SE; (2011) 'Evaluation of the Bruker SMART X2S: crystallography for the nonspecialist?'. Journal of Applied Crystallography, 44 :213-215 [DOI] [Full Text] [Details]
(2010)'Crystal polymorphs and transformations of 2-iodo-4-nitroaniline'
Moynihan, H; Kelly, Dawn; Eccles, Kevin; Elcoate, Curtis; Lawrence, Simon E; (2010) 'Crystal polymorphs and transformations of 2-iodo-4-nitroaniline'. Crystal Growth and Design, 10 :4303-4309 [DOI] [Full Text] [Details]
(2010)'Direction of copper phthalocyanine crystallization using in situ generated tethered phthalocyanines'
Moynihan, Humphrey A; Claudon, Geraldine; (2010) 'Direction of copper phthalocyanine crystallization using in situ generated tethered phthalocyanines'. CrystEngComm, [DOI] [Full Text] [Details]
(2010)'Synthesis and evaluation of fully (5-amidoisophthalic acid)- functionalised polyacrylamides as selective inhibitors of the beta crystal polymorph of L-glutamic acid'
Kelly, Dawn M; Moynihan, Humphrey A; (2010) 'Synthesis and evaluation of fully (5-amidoisophthalic acid)- functionalised polyacrylamides as selective inhibitors of the beta crystal polymorph of L-glutamic acid'. Tetrahedron, [DOI] [Details]
(2010)'Mimics of a R22(8) hydrogen-bond dimer motif: synthesis and influence on the crystallisation of sulfathiazole and sulfapyridine'
Lawrence, SE; McAuliffe, MT; Moynihan HA; (2010) 'Mimics of a R22(8) hydrogen-bond dimer motif: synthesis and influence on the crystallisation of sulfathiazole and sulfapyridine'. European Journal of Organic Chemistry, 6 :1134-1141 [Details]
(2010)'Interaction of acridine-calix[4]arene with DNA at the electrified liqui|liquid interface'
Kivlehan, Francine; Lefoix, Myriam; Moynihan, Humphrey A; Thompson, Damien; Ogurtsov, Vladimir I; Herzog, Gregoire; Arrigan, Damien WM; (2010) 'Interaction of acridine-calix[4]arene with DNA at the electrified liqui|liquid interface'. Electrochimica Acta, 55 (9):3348-3354 [Details]
(2009)'Study of electrochemical phosphate sensing systems: Spectrometric, potentiometric and voltammetric evaluation'
Francine Kivlehan, Wade J. Mace, Humphrey A. Moynihan*, Damien W. M. Arrigan; (2009) 'Study of electrochemical phosphate sensing systems: Spectrometric, potentiometric and voltammetric evaluation'. Electrochimica Acta, 54 :1919-1924 [Details]
(2009)'14beta-O-Cinnamoylnaltrexone and Related Dihydrocodeinones are Mu Opioid Partial Agonists with predominant Antagonist Activity'
H. Moynihan, A. R. Jules, B. M. Greedy, D. Rennison, J. H. Broadbear, L. Purington, J. R. Traynor, J. H. Woods, J. W. Lewis, and S. M. Husbands; (2009) '14beta-O-Cinnamoylnaltrexone and Related Dihydrocodeinones are Mu Opioid Partial Agonists with predominant Antagonist Activity'. Journal of medicinal chemistry, 52 (6):1553-1557 [Details]
(2009)'Selective Nonomolar Detection of Dopamine Using a Boron-Doped Diamond Electrode Modified with an Electropolymerized Sulfobutylether-beta-cyclodextrin-Doped Poly(N-acetyltyramine) and Polypyrrole Composite Film'
F. J. Shang, :L. Zhou, K. A. Mahmoud, S. Hrapovic, Y. L. Liu, H. A. Moynihan, J. D. Glennon, J. H. T. Luong (2009) 'Selective Nonomolar Detection of Dopamine Using a Boron-Doped Diamond Electrode Modified with an Electropolymerized Sulfobutylether-beta-cyclodextrin-Doped Poly(N-acetyltyramine) and Polypyrrole Composite Film'. Analytical Chemistry, 81 (10):4089-4098 [Details]
(2008)'Electrochemistry of dopamine at the polarised liquid/liquid facilitated by an homo-oxo-calix[3]arene ionophore'
, Grégoire Herzog, Brian McMahon, Myriam Lefoix, Nicholas D. Mullins, Courtney J. Collins, Humphrey A. Moynihan, Damien W. M. Arrigan; (2008) 'Electrochemistry of dopamine at the polarised liquid/liquid facilitated by an homo-oxo-calix[3]arene ionophore'. J. Electroanal. Chem, 622 (1):109-114 [Details]
(2008)'Effect of 1-Deoxy-D-lactose upon the Crystallization of D-Lactose'
Kevin P. Guiry, Simon J. Coles, Humphrey A. Moynihan, and Simon E. Lawrence; (2008) 'Effect of 1-Deoxy-D-lactose upon the Crystallization of D-Lactose'. Crystal Growth and Design, 8 (11):3927-3934 [DOI] [Full Text] [Details]
(2007)'Monomeric and polymeric derivatives of 5-aminoisophthalic acid as selective inhibitors of the beta-polymorph of L-glutamic acid'
J.M. Kelleher, S.E. Lawrence, M.T. McAuliffe and H.A. Moynihan; (2007) 'Monomeric and polymeric derivatives of 5-aminoisophthalic acid as selective inhibitors of the beta-polymorph of L-glutamic acid'. CrystEngComm, 9 (1):72-77 [Details]
(2007)'Potentiometric evaluation of calix[4]arene anion receptors in membrane electrodes: Phosphate detection'
Francine Kivlehan; Wade J. Mace; Humphrey A. Moynihan, Damien W. M. Arrigan; (2007) 'Potentiometric evaluation of calix[4]arene anion receptors in membrane electrodes: Phosphate detection'. Anal. Chim. Acta, 585 :154-160 [Details]
(2007)'Crystal polymorphism of pharmceuticals: probing crystal nucleation at the molecular level'
Guiry, K.P.; Kelleher, J.M.; Lawrence, S.E.; McAuliffe, M.T.; Moynihan, H.A; Ryan, A.L.;; (2007) 'Crystal polymorphism of pharmceuticals: probing crystal nucleation at the molecular level'. Journal of Enzyme Inhibition and Medicinal Chemistry, in press (*):*-* [Details]
(2007)'Biotransformation and stereoselective synthesis of pharmaceutical molecules from linoleic acid'
O. Muhammad Nor, N. N. Nor, H. Moynihan, R. Hamilton (2007) 'Biotransformation and stereoselective synthesis of pharmaceutical molecules from linoleic acid'. Biotechnology, 6 (2):283-287 [Details]
(2006)'Effect of the steric demand and hydrogen bonding capacity of additives on the crystal polymorphism of sulfathiazole'
, Joanne M. Kelleher, Simon E. Lawrence and Humphrey A. Moynihan; (2006) 'Effect of the steric demand and hydrogen bonding capacity of additives on the crystal polymorphism of sulfathiazole'. CrystEngComm, 8 :327-332 [Details]
(2006)'Alginate-Chitosan Beads: Determining the Influence of Processing Parameters on Bead Formation'
Blackshields, C. A, Oliveira, J., Moynihan, H.A., Crean, A.M; (2006) 'Alginate-Chitosan Beads: Determining the Influence of Processing Parameters on Bead Formation'. J. Pharm. Pharmacol, Supplement 1 [Details]
(2006)'Structural Determinants of Opioid Activity in Derivatives of 14-Aminomorphinones: Effect of Substitution in the Aromatic Ring of Cinnamoylaminomorphinones and Codeinones'
, Nick P. R. Nieland, Humphrey A. Moynihan, Simon Carrington, Jillian Broadbear, James H. Woods, John R. Traynor, Stephen M. Husbands*, and John W. Lewis; (2006) 'Structural Determinants of Opioid Activity in Derivatives of 14-Aminomorphinones: Effect of Substitution in the Aromatic Ring of Cinnamoylaminomorphinones and Codeinones'. J. Med. Chem, 49 (17):5333-5338 [Details]
(2006)'Structural determinants of opioid activity in derivatives of 14-aminomorphinones: Effects of changes to the chain linking of the C-14-amino group to the aryl ring'
David Rennison, Humphrey Moynihan, John R. Traynor, John W. Lewis, Stephen M. Husbands*,; (2006) 'Structural determinants of opioid activity in derivatives of 14-aminomorphinones: Effects of changes to the chain linking of the C-14-amino group to the aryl ring'. J. Med. Chem, 49 (20):6104-6110 [Details]
(2005)'Preparation and stereochemical integrity of certain thioesters of 2-arylpropionic acids and related compounds'
Patrick E. Hanrahan and Humphrey A. Moynihan; (2005) 'Preparation and stereochemical integrity of certain thioesters of 2-arylpropionic acids and related compounds'. J. Pharm. Pharmacol, 57 :1619-1627 [Details]
(2003)'Scaling-up the production of 13S-hydroxy-9Z,11E-octadecadienoic acid (13S-HODE) through chemoenzymatic technique'
Muhammad N. Omar, Humphrey A. Moynihan and Richard J. Hamilton*,; (2003) 'Scaling-up the production of 13S-hydroxy-9Z,11E-octadecadienoic acid (13S-HODE) through chemoenzymatic technique'. Bulletin of the Korean Chemical Society, 24 (3):397-399 [Details]
(2003)'Asymmetric Sharpless epoxidation of 13S-hydroxy-9Z,11E-octadecadienoic acid'
Muhammad N. Omar, Humphrey A. Moynihan and Richard J. Hamilton; (2003) 'Asymmetric Sharpless epoxidation of 13S-hydroxy-9Z,11E-octadecadienoic acid'. European Journal of Lipid Science and Technology, 105 (1):43-44 [Details]
(2003)'Stereoselective preparations of epoxy-, fluoro- and related derivatives of ricinoleic acid and 13(S)-hydroxyoctadeca-9(Z),11(E)-dienoic acid'
Muhammad Nor Bin Omar, Richard J. Hamilton and Humphrey A. Moynihan; (2003) 'Stereoselective preparations of epoxy-, fluoro- and related derivatives of ricinoleic acid and 13(S)-hydroxyoctadeca-9(Z),11(E)-dienoic acid'. ARKIVOC, (7):190-199 [Details]
(2002)'Spectroscopic characterisation of orthorhombic and monoclinic paracetamol'
, Humphrey. A. Moynihan* and Iain. P. O'Hare; (2002) 'Spectroscopic characterisation of orthorhombic and monoclinic paracetamol'. International Journal of Pharmaceutics, 247 :179-185 [Details]
(2001)'Synthesis and hydrolytic behaviour of glycerol-1,2-diibuprofenate-3-nitrate, a putative pro-drug of ibuprofen and glycerol-1-nitrate'
M. J. Ingram, H. A. Moynihan*, M. W. Powell, C. Rostron; (2001) 'Synthesis and hydrolytic behaviour of glycerol-1,2-diibuprofenate-3-nitrate, a putative pro-drug of ibuprofen and glycerol-1-nitrate'. J. Pharm. Pharmacol, 53 :345-350 [Details]
(2001)'Self-reactivity of s-triazine and its radical cation: an electron/proton transfer process driven by ionizing radiation'
C. J. Rhodes* and H. A. Moynihan; (2001) 'Self-reactivity of s-triazine and its radical cation: an electron/proton transfer process driven by ionizing radiation'. Magnetic Resonance in Chemistry, 39 (3):133-136 [Details]
(2000)'Compaction and thermal properties of a series of ibuprofen salts'
Madeline R. Whelan, Matthew J. Ingram, Claire Madden, James L. Ford*, Humphrey A. Moynihan; (2000) 'Compaction and thermal properties of a series of ibuprofen salts'. J.Pharm. Pharmacol, 52 (Supplement) [Details]
(2000)'Spin-Labelling with the Second Hydrogen Radioisotope: Radicals Formed from Squalene by Muonium Addition'
Christopher J. Rhodes*, Timothy C. Dintinger, Humphrey A. Moynihan and Ivan D. Reid, ; (2000) 'Spin-Labelling with the Second Hydrogen Radioisotope: Radicals Formed from Squalene by Muonium Addition'. Free Radical Research, 33 :75-79 [Details]
(2000)'Radiolabelling Studies of Free Radical Reactions using Muonium (the Second Hydrogen Radioisotope): Evidence of a Direct Antioxidant Role for Vitamin K in Repair of Oxidative Damage to Lipids'
, Christopher J. Rhodes*, Timothy C. Dintinger and Humphrey A. Moynihan; (2000) 'Radiolabelling Studies of Free Radical Reactions using Muonium (the Second Hydrogen Radioisotope): Evidence of a Direct Antioxidant Role for Vitamin K in Repair of Oxidative Damage to Lipids'. Magnetic Resonance in Chemistry, 38 :646-649 [Details]
(2000)'14-Cinnamoyl and fumaroyl derivatives of naltrexone'
S. M. Husbands, H. Moynihan, J. H. Woods, J. R. Traynor, J. Broadbear, H. Plumer, J. W. Lewis (2000) '14-Cinnamoyl and fumaroyl derivatives of naltrexone'. Drug and alcohol dependence, 60 (Supplementary 1):S96-S97 [Details]
(1999)'Hydrolysis of ibuprofen propyl ester in a physiologically-based model with direct analysis by reverse phase HPLC'
. J. Ingram, H. A. Moynihan*, M. W. Powell and C. Rostron; (1999) 'Hydrolysis of ibuprofen propyl ester in a physiologically-based model with direct analysis by reverse phase HPLC'. J. Pharm. Pharmacol, 51 (Supplement) [Details]
(1998)'Improved Selective Protections of L-Arginine'
Humphrey A. Moynihan and WeipingYu,; (1998) 'Improved Selective Protections of L-Arginine'. Synthetic Communications, 28 :17-23 [Details]
(1998)'Guanidino-substituted arginines via N-silyl intermediates'
, H. A. Moynihan* and W. Yu, ; (1998) 'Guanidino-substituted arginines via N-silyl intermediates'. J. Pharm. Pharmacol, 50 (Supplement) [Details]
(1998)'Synthesis and nitration of ibuprofen 1-monoglyceride'
M. J. Ingram, H. A. Moynihan and C. Rostron, ; (1998) 'Synthesis and nitration of ibuprofen 1-monoglyceride'. J. Pharm. Pharmacol, 50 (Supplement) [Details]
(1998)'Alkoxycarbonylation and Selective Deprotection of N-Silyl Derivatives of L-Arginine'
Humphrey A. Moynihan+ and Weiping Yu; (1998) 'Alkoxycarbonylation and Selective Deprotection of N-Silyl Derivatives of L-Arginine'. Tetrahedron Letters, 39 :3349-3352 [Details]
(1997)'Cyclisations of Benzenesulfanyl Chloride Adducts with Conjugated Silyloxyenones: A New Stereoselective Reaction in the Synthesis of 4,5-Dihydro-3(2H)-Furanones'
Conor C. Collins, Michael F. Cronin, Humphrey A. Moynihan and Daniel G. McCarthy; (1997) 'Cyclisations of Benzenesulfanyl Chloride Adducts with Conjugated Silyloxyenones: A New Stereoselective Reaction in the Synthesis of 4,5-Dihydro-3(2H)-Furanones'. J. Chem. Soc., Perkin Transactions 1, :1267-1269 [Details]
(1996)'Potential Irreversible Ligands for Opioid Receptors. Cinnamoyl Derivatives of -Naltrexamine'
, Ian Derrick, John W. Lewis*, Humphrey A. Moynihan, Gillian Broadbear and James H. Woods; (1996) 'Potential Irreversible Ligands for Opioid Receptors. Cinnamoyl Derivatives of -Naltrexamine'. J. Pharm. Pharmacol, 48 :192-196 [Details]
(1996)'6N-Cinnamoyl -Naltrexamine and its para-Nitro Derivatives. High Efficacy -Opiate Agonists with Weak Antagonist Action'
Ian Derrick, Humphrey A. Moynihan and John W. Lewis; (1996) '6N-Cinnamoyl -Naltrexamine and its para-Nitro Derivatives. High Efficacy -Opiate Agonists with Weak Antagonist Action'. Bio-organic and Medicinal Chemistry Letters, 6 :167-172 [Details]
(1995)'Molecular Modelling of Fumarimido and Cinnamoylamido Derivatives in Epoxy- Morphinans. Correlation with Pharmacological Profiles'
Neil G. Piggot, Ian Derrick, Humphrey A. Moynihan, Stephen M. Husbands, John W. Lewis* and James H. Woods; (1995) 'Molecular Modelling of Fumarimido and Cinnamoylamido Derivatives in Epoxy- Morphinans. Correlation with Pharmacological Profiles'. Analgesia, 1 :386-389 [Details]
(1994)'Synthesis and Biological Activity of the Novel Nitric Oxide Synthase Inhibitor N'-Hydroxy-N-methyl-L-arginine'
Humphrey A. Moynihan, Stanley M. Roberts*, Hazel Weldon Graham H. Allcock, Erik E. Anggard and Timothy D. Warner; (1994) 'Synthesis and Biological Activity of the Novel Nitric Oxide Synthase Inhibitor N'-Hydroxy-N-methyl-L-arginine'. J. Chem. Soc.,Perkin Transactions 1, :769-771 [Details]
(1994)'Preparation of Some Novel S-Nitroso Compounds as Potential Slow-release Agents of Nitric Oxide in vivo'
Humphrey A. Moynihan and Stanley M. Roberts; (1994) 'Preparation of Some Novel S-Nitroso Compounds as Potential Slow-release Agents of Nitric Oxide in vivo'. J. Chem. Soc.,Perkin Transactions 1, :797-805 [Details]

Book Chapters

 YearPublication
(2015)'Impurity exclusion and retention during crystallisation and recrystallisation; the phenacetin by ethylation of paracetamol process'
Horgan, Danielle E.; Crowley, Lorraine M.; Stokes, Stephen P.; Lawrence, Simon E.; Moynihan, Humphrey A. (2015) 'Impurity exclusion and retention during crystallisation and recrystallisation; the phenacetin by ethylation of paracetamol process' In: Mastai, Yitzhak (eds). Advanced topics in crystallization. Rijeka: InTech.   [DOI] [Full Text] [Details]
(2012)'Phenacetin Crystallization: Cooling Regimes and Crystal Morphology'
Humphrey A. Moynihan and Dawn M. Kelly (2012) 'Phenacetin Crystallization: Cooling Regimes and Crystal Morphology' In: Crystallization Science and Technology. Croatia: InTech. [Details]
(2005)'Comprehensive Organic Functional Group Transformations'
Humphrey A. Moynihan; (2005) 'Comprehensive Organic Functional Group Transformations' In: Alkyl Metals. Oxford: Elsevier. [Details]

Books

 YearPublication
(2009)The Physicochemical Basis of Pharmaceuticals.
Humphrey Moynihan and Abina Crean; (2009) The Physicochemical Basis of Pharmaceuticals. Oxford: Oxford University Press. [Details]

Professional Activities

Conference Contributions

 YearPublication
(2014)XXIIth European Conference of the Groupement des Pharmacochimistes de l’Arc Atlantique,
D. E. Horgan and H. A. Moynihan (2014) Ketoprofen Tris and Related Salts: Phase Behaviour and Pharmaceutical Potential. [Poster Presentation], XXIIth European Conference of the Groupement des Pharmacochimistes de l’Arc Atlantique, University of Nantes . [Details]
(2014)Quarterly Technical Meeting of the SFI Synthesis and Solid-state Pharmaceutical Centre,
Danielle Horgan and Humphrey Moynihan (2014) T5 Impurity Effects in Crystallisation. [Oral Presentation], Quarterly Technical Meeting of the SFI Synthesis and Solid-state Pharmaceutical Centre, UCC , 03-DEC-14. [Details]
(2014)SFI Synthesis and Solid State Pharmaceutical Centre Quarterly Technical Meeting,
Humphrey Moynihan, Åke Rasmuson, Kieran Hodnett, Alan Ryder, Simon Lawrence, Andrea Erxleben, John Hayes, Danielle Horgan, Boyan Li, Hien Nguyen (2014) T5 Impurity Effects in Crystallisation. [Oral Presentation], SFI Synthesis and Solid State Pharmaceutical Centre Quarterly Technical Meeting, University College Dublin . [Details]
(2014)XXIIth European Conference of the Groupement des Pharmacochimistes de l’Arc Atlantique,
L. M. Shanahan and H. A. Moynihan (2014) N,N’’-Bisalkyl Quinacridones: Solubilised Pigments for Pharmaceutical and Biological Application. [Poster Presentation], XXIIth European Conference of the Groupement des Pharmacochimistes de l’Arc Atlantique, University of Nantes . [Details]
(2014)SFI Synthesis and Solid State Pharmaceutical Centre Quarterly Technical Meeting,
Louise Shanahan and Humphrey Moynihan (2014) P5 Crystallisation Kinetics WP1 Solution Structure WP2 Nucleation. [Oral Presentation], SFI Synthesis and Solid State Pharmaceutical Centre Quarterly Technical Meeting, UCC , 03-DEC-14. [Details]
(2013)3rd Almac/UCC Joint Symposium,
Humphrey Moynihan (2013) Crystal Chemistry of Sugar Derivatives. [Oral Presentation], 3rd Almac/UCC Joint Symposium, University College Cork , 09-SEP-13. [Details]
(2013)21st European Conferences of the Groupment des Pharmacochimistes de l'Arc Atlantiques,
Danielle Horgan, Kevin Eccles, Humphrey Moynihan (2013) Impurity impact on crystallisation of an active pharmaceutical ingredient. [Poster Presentation], 21st European Conferences of the Groupment des Pharmacochimistes de l'Arc Atlantiques, Lille , 05-JUN-13 - 07-JUN-13. [Details]
(2013)21st European Conferences of the Groupment des Pharmacochimistes de l'Arc Atlantiques,
Lorna Lennon, Humphrey Moynihan (2013) Deoxycellodextrins as putative isostructures of cellulose polymorphs. [Poster Presentation], 21st European Conferences of the Groupment des Pharmacochimistes de l'Arc Atlantiques, Lille , 05-JUN-13 - 07-JUN-13. [Details]
(2013)21st European Conferences of the Groupment des Pharmacochimistes de l'Arc Atlantiques,
John A. Hayes and Humphrey A. Moynihan (2013) The synthesis of some alanine and phenylglycine oligopeptides and polyarginine carboxylates. [Poster Presentation], 21st European Conferences of the Groupment des Pharmacochimistes de l'Arc Atlantiques, Lille , 05-JUN-13 - 07-JUN-13. [Details]
(2013)1st Technical Meeting of the Synthesis and Solid-State Pharmaceutical Centre,
Humphrey A. Moynihan (2013) T5 Impurities in Crystallisation: Overview and Recent Work. [Oral Presentation], 1st Technical Meeting of the Synthesis and Solid-State Pharmaceutical Centre, University College Cork , 10-DEC-13. [Details]
(2012)10th International Workshop on the Crystal Growth of Organic Materials,
Lorna A. Lennon, Dawn M. Kelly, Kevin S. Eccles, Simon E. Lawrence and Humphrey A. Moynihan (2012) Building a common structural motif for glycoside derivatives. [Poster Presentation], 10th International Workshop on the Crystal Growth of Organic Materials, University of Limerick , 11-JUN-12 - 14-JUN-12. [Details]
(2012)Symposium on Recent Advances in Synthesis and Chemical Biology XI,
Lorna A. Lennon, Humphrey A. Moynihan (2012) Small scale analogues of cellulose as isostructures of cellulose polymorphs. [Poster Presentation], Symposium on Recent Advances in Synthesis and Chemical Biology XI, Royal College of Surgeons, Dublin , 14-DEC-12 - 14-DEC-12. [Details]
(2012)10th International Workshop on the Crystal Growth of Organic Materials,
Humphrey A. Moynihan, John Hayes, Lorna Lennon, Kevin Eccles, Simon E. Lawrence (2012) Approaches to crystal engineering with functionalised sugars. [Oral Presentation], 10th International Workshop on the Crystal Growth of Organic Materials, University of Limerick , 11-JUN-12 - 14-JUN-12. [Details]
(2012)10th International Workshop on the Crystal Growth of Organic Materials,
John A. Hayes, Humphrey A. Moynihan (2012) Supramolecular motifs in glucose oligosaccharides bearing primary amides on the glycosidic side chains. [Poster Presentation], 10th International Workshop on the Crystal Growth of Organic Materials, University of Limerick , 11-JUN-12 - 14-JUN-12. [Details]
(2012)Symposium on Recent Advances in Synthesis and Chemical Biology XI,
Humphrey A. Moynihan and John Hayes (2012) The synthesis of some alanine and phenylglycine oligopeptides and polyarginine carboxylates. [Poster Presentation], Symposium on Recent Advances in Synthesis and Chemical Biology XI, Royal College of Surgeons, Dublin , 14-DEC-12 - 14-DEC-12. [Details]
(2011)XXth Conference of the Groupment des Pharmacochimistes de l'Arc Atlantiques,
L. A. Lennon, K. S. Eccles, S. E. Lawrence, H. A. Moynihan (2011) Crystal structures of aryl glycosides, glucuronides and cellobiosides. [Poster Presentation], XXth Conference of the Groupment des Pharmacochimistes de l'Arc Atlantiques, UCC , 01-SEP-11 - 02-SEP-11. [Details]
(2011)RSC Carbohydrate & Bioorganic Groups Joint Spring Meeting,
John Hayes, Humphrey A. Moynihan, Simon E. Lawrence, Kevin Eccles (2011) Synthetic methodologies, crystallisation and solid state investigations of glucuronides and their intermediates. [Poster Presentation], RSC Carbohydrate & Bioorganic Groups Joint Spring Meeting, King's College London , 05-APR-11. [Details]
(2011)Bruker/ABCRF Structure Solutions Seminar,
Humphrey Moynihan (2011) Crystal Chemistry of some Bio-active Sugars. [Oral Presentation], Bruker/ABCRF Structure Solutions Seminar, UCC , 17-NOV-11. [Details]
(2011)XXth Conference of the Groupment des Pharmacochimistes de l'Arc Atlantiques,
J. A. Hayes, H. A. Moynihan, S. E. Lawrence, K. S. Eccles (2011) Synthesis and solid-state characterisation of N-substituted derivatives of cellobiose. [Poster Presentation], XXth Conference of the Groupment des Pharmacochimistes de l'Arc Atlantiques, UCC , 01-SEP-11 - 02-SEP-11. [Details]
(2011)RSC Carbohydrate & Bioorganic Groups Joint Spring Meeting,
Dawn M. Kelly, Lorna A. Lennon, Matthew M. O'Neill, Kevin S. Eccles, Simon E. Lawrence and Humphrey A. Moynihan (2011) Crystal structures of glycoside derivatives on route to glucuronide formation via TEMPO oxidation. [Poster Presentation], RSC Carbohydrate & Bioorganic Groups Joint Spring Meeting, King's College London, , 05-APR-11. [Details]
(2011)British Association for Crystal Growth Annual Conference 2011,
D. M. Kelly, L. A. Lennon, M. M. O'Neill, K. S. Eccles, S. E. Lawrence, H. A. Moynihan (2011) Crystal Structures of Aryl Glycosides, Glucuronides and Cellobiosides. [Poster Presentation], British Association for Crystal Growth Annual Conference 2011, University College London , 10-JUL-11 - 12-JUL-11. [Details]
(2011)Control and Prediction of the Organic Solid State Open Meeting,
L. Fábián, N. Hamill, K. S. Eccles, H. A. Moynihan, A. R. Maguire, L. McCausland, S. E. Lawrence (2011) Fenamic acid nicotinamide cocrystals: What can we predict?,. [Poster Presentation], Control and Prediction of the Organic Solid State Open Meeting, UCL London , 30-MAR-11. [Details]
(2011)5th CPOSS Open day,
L. Fabian, N. Hamill, K. S. Eccles, H. A. Moynihan, A. R. Maguire, L. McCausland, S. E. Lawrence (2011) Fenamic acid nicotinamide cocrystals: what can we predict?. [Poster Presentation], 5th CPOSS Open day, University College London . [Details]
(2010)19th European Conference of the Group of Medicinal Chemists of the Atlantic Arc - GP2A,
Lennon, L.A., Moynihan, H.A., (2010) The preparation of glucuronide derivatives. [Poster Presentation], 19th European Conference of the Group of Medicinal Chemists of the Atlantic Arc - GP2A, Rouen , 01-SEP-10 - 02-SEP-11. [Details]
(2010)19th European Conference of the Group of Medicinal Chemists of the Atlantic Arc - GP2A,
John Hayes, Humphrey A. Moynihan, Simon Lawrence, Curtis Elcoate and Kevin Eccles (2010) Synthetic methodologies, crystallisation and solid state investigations of glucuronides and their intermediates. [Poster Presentation], 19th European Conference of the Group of Medicinal Chemists of the Atlantic Arc - GP2A, Rouen , 01-SEP-10 - 02-SEP-10. [Details]
(2010)Almac/UCC Joint Symposium on Pharmaceutical Polymorphs and Cocrystallization,
Dawn Kelly and H. A. Moynihan (2010) Crystallization using the HEL AutoLab and LaserTrack system. [Oral Presentation], Almac/UCC Joint Symposium on Pharmaceutical Polymorphs and Cocrystallization, UCC , 28-APR-10. [Details]
(2010)19th European Conference of the Group of Medicinal Chemists of the Atlantic Arc - GP2A,
Dawn M. Kelly, Curtis Elcoate, Kevin Eccles, Simon E. Lawrence, Humphrey A. Moynihan (2010) Optimising pharmaceutical solids; a critical step on the route from molecules to medicines. [Oral Presentation], 19th European Conference of the Group of Medicinal Chemists of the Atlantic Arc - GP2A, Rouen , 01-SEP-10 - 02-SEP-10. [Details]
(2010)UCC College of Medicine and Health Conference,
Dawn M. Kelly and Humphrey A. Moynihan (2010) Optimizing pharmaceutical solids; a critical step on the route from molecules to medicines. [Oral Presentation], UCC College of Medicine and Health Conference, UCC , 16-JUN-10. [Details]
(2009)7th Annual Eli Lilly Research Symposium in Organic & Pharmaceutical Chemistry,
Dawn Kelly and H. A. Moynihan (2009) PXRD and NMR studies on the crystallization of paracetamol derivatives. [Oral Presentation], 7th Annual Eli Lilly Research Symposium in Organic & Pharmaceutical Chemistry, UCC , 02-OCT-09. [Details]
(2009)British Association of Crystal Growth, 40th Anniversary Conference,
J. Hayes, H. A. Moynihan (2009) Crystallisation and crystal forms of Paracetamol-O-glucuronide. [Poster Presentation], British Association of Crystal Growth, 40th Anniversary Conference, University of Bristol , 06-SEP-09 - 08-SEP-09. [Details]
(2009)British Association of Crystal Growth, 40th Anniversary Conference,
G. Claudon, H. A. Moynihan (2009) New process for the preparation of the alpha polymorph of copper phthalocyanine. [Poster Presentation], British Association of Crystal Growth, 40th Anniversary Conference, University of Bristol , 06-SEP-09 - 08-SEP-09. [Details]
(2009)British Association of Crystal Growth, 40th Anniversary Conference,
D. M. Kelly and H. A. Moynihan (2009) Probing and controlling the crystallisation of 2-iodo-4-nitroaniline. [Poster Presentation], British Association of Crystal Growth, 40th Anniversary Conference, University of Bristol , 06-SEP-09 - 08-SEP-09. [Details]
(2009)Quaterly Technical Meeting of the Solid State Pharmaceutical Cluster,
John Hayes and H. A. Moynihan (2009) The Synthesis, Crystallisation and Crystal Forms of Paracetamol-O-Glucuronide. [Oral Presentation], Quaterly Technical Meeting of the Solid State Pharmaceutical Cluster, University of Limerick , 03-SEP-09. [Details]
(2009)British Association of Crystal Growth, 40th Anniversary Conference,
S. P. McSweeney, H. A. Moynihan, S. E. Lawrence (2009) Investigations into the crystal chemistry of sulfonilamides and their phenol and thiophenol analogues. [Poster Presentation], British Association of Crystal Growth, 40th Anniversary Conference, University of Bristol , 06-SEP-09 - 08-SEP-09. [Details]
(2009)Synthesis of Biologically Active Molecules V,
Humphrey A. Moynihan (2009) Bioactive molecules in the crystalline solid state. [Oral Presentation], Synthesis of Biologically Active Molecules V, UCC , 14-MAY-09. [Details]
(2009)SSPC Quarterly Technical Meeting,
Dawn Kelly and H. A. Moynihan (2009) PXRD and NMR studies on the crystallization of paracetamol derivatives. [Oral Presentation], SSPC Quarterly Technical Meeting, NUI Galway , 10-MAR-09. [Details]
(2009)Polymorphism & Crystallisation Conference,,
Andrea L. Ryan, Marie T. McAuliffe and H.A. Moynihan (2009) Tailor-made polymeric additives as crystallisation controlling agents. [Poster Presentation], Polymorphism & Crystallisation Conference,, Brussels , 19-MAR-09 - 20-MAR-09. [Details]
(2009)Polymorphism & Crystallisation Conference,
Kevin P. Guiry, S. E. Lawrence and H. A. Moynihan (2009) Aspects of lactose crystallisation. [Poster Presentation], Polymorphism & Crystallisation Conference, Brussels , 19-MAR-09 - 20-MAR-09. [Details]
(2009)Electrochemistry conference organised by the Société Française de Chimie,
Grégoire Herzog, Francine Kivlehan, Myriam Lefoix, Jörg Strutwolf, Damien Thompson, Vladimir I. Ogurtsov, Humphrey A. Moynihan, Damien W.M. Arrigan (2009) DNA and calix[4]arene-acridine interactions at the liquid | liquid interface. [Poster Presentation], Electrochemistry conference organised by the Société Française de Chimie, Romania , 02-SEP-09 - 04-SEP-09. [Details]
(2009)Institute of Chemistry of Ireland Annual Congress,
H. A. Moynihan (2009) Molecular crystalline solids; the physical form of the chemistry – biology interface. [Oral Presentation], Institute of Chemistry of Ireland Annual Congress, University College Dublin , 22-MAY-09. [Details]
(2008)Solid State Pharmaceutical Cluster, General Meeting,
Marie T. McAuliffe and Humphrey A. Moynihan; (2008) Effect on sulfathiazole crystallization of mimics of the R22(8) hydrogen bond motif. [Oral Presentation], Solid State Pharmaceutical Cluster, General Meeting, University of Limerick , 09-MAY-08 - 09-MAY-08. [Details]
(2007)Arrigan 58th Annual Meeting of the International Society of Electrochemistry,
Grégoire Herzog, Brian McMahon, Myriam Lefoix, Humphrey Moynihan, Damien W.M; (2007) Dopamine detection at the polarised liquid-liquid interface using an oxacalixarene. [Oral Presentation], Arrigan 58th Annual Meeting of the International Society of Electrochemistry, Banff, Canada , 09-SEP-07 - 14-SEP-07. [Details]
(2007)British Association for Crystal Growth & Irish Association for Crystal Growth Conference 2007,
Sharon McSweeney, S. E. Lawrence & H. A. Moynihan; (2007) Hydrogen bonding and polymorphism in sulfanilamide-like sulfonamides. [Oral Presentation], British Association for Crystal Growth & Irish Association for Crystal Growth Conference 2007, University College Dublin , 03-SEP-07 - 04-SEP-07. [Details]
(2007)British Association for Crystal Growth & Irish Association for Crystal Growth, Conference 2007,,
Dawn Kelly, Marie McAuliffe and H. A. Moynihan; (2007) Probing the effect of additives on the crystallization of L-Glutamic acid. [Oral Presentation], British Association for Crystal Growth & Irish Association for Crystal Growth, Conference 2007,, University College Dublin, , 03-SEP-07 - 04-SEP-07. [Details]
(2007)British Association for Crystal Growth & Irish Association for Crystal Growth, Conference 2007,,
Humphrey A. Moynihan; (2007) Molecular-level approaches to crystal polymorph control. [Oral Presentation], British Association for Crystal Growth & Irish Association for Crystal Growth, Conference 2007,, University College Dublin , 03-SEP-07 - 04-SEP-07. [Details]
(2007)59th Irish Universities Chemistry Research Colloquium,
K.P. Guiry, S.E. Lawrence & Humphrey A. Moynihan; (2007) Aspects of D-lactose crystallization,. [Oral Presentation], 59th Irish Universities Chemistry Research Colloquium, Dublin City University , 13-JUN-07 - 15-JUN-07. [Details]
(2007)29th All-Ireland Schools of Pharmacy Research Seminar,
K.P. Guiry, S.J. Coles, S.E. Lawrence, & H.A. Moynihan; (2007) Aspects of D-Lactose Crystallization. [Oral Presentation], 29th All-Ireland Schools of Pharmacy Research Seminar, RCSI Dublin , 02-APR-07 - 03-APR-07. [Details]
(2007)European Federation of Chemical Engineers Working Party on Crystallization, Technical Meeting,
K.P. Guiry, S.J. Coles, S.E. Lawrence, & H.A. Moynihan; (2007) Aspects of D-Lactose Crystallization. [Oral Presentation], European Federation of Chemical Engineers Working Party on Crystallization, Technical Meeting, University College Dublin , 23-MAR-07 - 23-MAR-07. [Details]
(2006)Developing Expertise in Pharmaceutical Materials and Bio-materials,
Humphrey A. Moynihan; (2006) Developing Expertise in Pharmaceutical Materials and Bio-materials. [Oral Presentation], Developing Expertise in Pharmaceutical Materials and Bio-materials, Weizmann Institute of Science, Israel , 24-SEP-06 - 24-SEP-07. [Details]
(2006)Groupement des Pharmacochimistes de l'Arc Atlantique, 15th Conference,
K.P. Guiry, S.E. Lawrence, & H.A. Moynihan; (2006) Characterisation of crystalline forms of D-lactose,. [Oral Presentation], Groupement des Pharmacochimistes de l'Arc Atlantique, 15th Conference, University of Bath , 07-SEP-06 - 08-SEP-06. [Details]
(2006)Groupement des Pharmacochimistes de l'Arc Atlantique, 15th Conference,,
Andrea L. Ryan and Humphrey A. Moynihan; (2006) EDTA-conjugates as crystallization-controlling agents. [Oral Presentation], Groupement des Pharmacochimistes de l'Arc Atlantique, 15th Conference,, University of Bath , 07-SEP-06 - 08-SEP-07. [Details]
(2006)2006 All-Ireland Schools of Pharmacy 28th Research Seminar,
K.P. Guiry, H.A. Moynihan & S.E. Lawrence; (2006) Crystallography and crystallization of D-lactose. [Oral Presentation], 2006 All-Ireland Schools of Pharmacy 28th Research Seminar, Queen's University Belfast, School of Pharmacy , 10-APR-06 - 11-APR-06. [Details]
(2006), 2006 All-Ireland Schools of Pharmacy 28th Research Seminar,
A. L. Ryan and H. A. Moynihan; (2006) EDTA-conjugates as crystallization controlling agents. [Oral Presentation], , 2006 All-Ireland Schools of Pharmacy 28th Research Seminar, Queen's University Belfast School of Pharmacy, , 10-APR-06 - 11-APR-06. [Details]
(2006)2006 All-Ireland Schools of Pharmacy 28th Research Seminar,
Caroline A. Blackshields, Jorge Oliveira, Humphrey A. Moynihan and Abina M. Crean; (2006) Alginate-Chitosan Beads: Determining the Influence of Processing Parameters on Bead Formation. [Invited Oral Presentation], 2006 All-Ireland Schools of Pharmacy 28th Research Seminar, Queen's University Belfast School of Pharmacy , 10-APR-06 - 11-APR-06. [Details]
(2006), 2006 All-Ireland Schools of Pharmacy 28th Research Seminar,
Marie McAuliffe and H. A. Moynihan; (2006) The effects of polymeric versus monomeric additives on the nucleation of L-glutamic acid. [Oral Presentation], , 2006 All-Ireland Schools of Pharmacy 28th Research Seminar, Queen's University Belfast School of Pharmacy, , 10-APR-06 - 11-APR-06. [Details]
(2005)Eli Lilly Postgraduate Research Symposium,
J.M. Kelleher, S.E. Lawrence & H.A. Moynihan; (2005) Influence of additives on crystal polymorphism and morphology: probing the effects of hydrogen bonding, conformational mimicry and co-operative binding. [Oral Presentation], Eli Lilly Postgraduate Research Symposium, University College Cork , 15-SEP-05 - 15-SEP-05. [Details]
(2005)XX Congress of the International Union of Crystallography,
J.M. Kelleher, S.E. Lawrence & H.A. Moynihan; (2005) Effect of Additive structure on Crystal Nucleation: Sulfathiazole. [Oral Presentation], XX Congress of the International Union of Crystallography, Florence, Italy , 23-AUG-05 - 31-AUG-05. [Details]
(2005)Crean Schools of Pharmacy Research Seminar,
Caroline A. Blackshields, Ken J. Devine, Humphrey. A. Moynihan, Abina M; (2005) The effect of pH on Levobupivacaine free base solubility and retention on reverse phase HPLC. [Oral Presentation], Crean Schools of Pharmacy Research Seminar, Trinity College Dublin, , 21-MAR-05 - 22-MAR-05. [Details]
(2005)Joint Queen's University Belfast/Trinity College Dublin Pharmacy Research Seminar,
Colman Carroll and Humphrey A. Moynihan; (2005) The preparation of O, S and novel N-linked derivatives of glucuronic acid. [Oral Presentation], Joint Queen's University Belfast/Trinity College Dublin Pharmacy Research Seminar, Trinity College Dublin , 21-MAR-05 - 22-MAR-05. [Details]
(2004)University College Cork/Royal Society of Chemistry Republic of Ireland Section/Analytical Division 3rd Biennial Conference on Analytical Sciences in Ireland,
Wade J. Mace, Emer K. Kelly, Humphrey A. Moynihan, Damien W. M. Arrigan; (2004) Liquid/Liquid Electrochemistry of Calixarene-Based Anion Receptors. [Oral Presentation], University College Cork/Royal Society of Chemistry Republic of Ireland Section/Analytical Division 3rd Biennial Conference on Analytical Sciences in Ireland, University College Cork , 09-SEP-04 - 10-SEP-04. [Details]
(2004)Eli Lilly Postgraduate Research 2nd Annual Symposium in Organic Chemistry,
H. A. Moynihan and P. E. Hanrahan; (2004) Synthesis and stereochemical integrity of 2-arylpropionate thioesters. [Oral Presentation], Eli Lilly Postgraduate Research 2nd Annual Symposium in Organic Chemistry, University College Cork , 07-SEP-04 - 07-SEP-04. [Details]
(2004)RSC Organic Reaction Mechanisms Group/Centre for Synthesis and Chemical Biology: Reaction Mechanisms VII,
P.E. Hanrahan, H.A. Moynihan; (2004) Synthesis and Stereochemical integrity of 2-arylpropionate thioesters and related compounds. [Oral Presentation], RSC Organic Reaction Mechanisms Group/Centre for Synthesis and Chemical Biology: Reaction Mechanisms VII, University College Dublin , 04-JUL-04 - 08-JUL-04. [Details]
(2004)Inaugural Analytical and Biological Chemistry Research Facility Research Day,
J. M. Kelleher, S. E. Lawrence and H. A. Moynihan; (2004) Probing the effects of steric demand and cooperative binding on crystal nucleation. [Oral Presentation], Inaugural Analytical and Biological Chemistry Research Facility Research Day, University College Cork, , 22-APR-04 - 22-APR-04. [Details]
(2004)RSC Organic Reaction Mechanisms Group/Centre for Synthesis and Chemical Biology: Reaction Mechanisms VII,
Wade J. Mace, Emer K. Kelly, Humphrey A. Moynihan, Damien W. M. Arrigan; (2004) Calixarene-Based Anion Receptors for Liquid/Liquid Electrochemistry. [Oral Presentation], RSC Organic Reaction Mechanisms Group/Centre for Synthesis and Chemical Biology: Reaction Mechanisms VII, University College Dublin , 04-JUL-04 - 08-JUL-04. [Details]
(2004)Inaugural Analytical and Biological Chemistry Research Facility Research Day,
H. A. Moynihan and P. E. Hanrahan; (2004) Synthesis and stereochemical integrity of 2-arylpropionate thioesters. [Oral Presentation], Inaugural Analytical and Biological Chemistry Research Facility Research Day, University College Cork , 22-APR-04 - 22-APR-04. [Details]
(2004)Inaugural Analytical and Biological Chemistry Research Facility Research Day,
Colman Carroll and Humphrey A. Moynihan; (2004) Synthesis of 1-amino-D-glucuronic acid and related compounds. [Oral Presentation], Inaugural Analytical and Biological Chemistry Research Facility Research Day, University College Cork , 22-APR-04 - 22-APR-04. [Details]
(2004)Inaugural Analytical and Biological Chemistry Research Facility Research Day,
Wade Mace, Emer K. Kelly, Humphrey A. Moynihan, Damien W. M. Arrigan; (2004) Calixarene-based Anion Receptors for Liquid/Liquid Electrochemistry. [Oral Presentation], Inaugural Analytical and Biological Chemistry Research Facility Research Day, University College Cork, , 22-APR-04 - 22-APR-04. [Details]
(2004)Joint Queen's University Belfast/Trinity College Dublin Pharmacy Research Seminar,
J. M. Kelleher, S. E. Lawrence and H. A. Moynihan; (2004) Probing the effects of steric demand and cooperative binding on pharmaceutical crystal nucleation. [Oral Presentation], Joint Queen's University Belfast/Trinity College Dublin Pharmacy Research Seminar, Queen's University Belfast, , 20-APR-04 - 21-APR-04. [Details]
(2004)Crystallisation of Organic Compounds,
Humphrey A. Moynihan; (2004) Crystallisation of Organic Compounds. [Oral Presentation], Crystallisation of Organic Compounds, Pfizer Pharmaceuticals (Ireland), Ringaskiddy, Cork , 24-SEP-04 - 24-SEP-04. [Details]
(2006)Groupement des Pharmacochimistes de l'Arc Atlantique, 15th Conference,
Humphrey A. Moynihan; (2006) Probing pharmaceutical crystal nucleation at the molecular level. [Oral Presentation], Groupement des Pharmacochimistes de l'Arc Atlantique, 15th Conference, University of Bath , 07-SEP-06 - 08-SEP-06. [Details]
(2008)Synthesis of Bioactive Molecules IV,
Humphrey A. Moynihan; (2008) . [Conference Organising Committee Member], Synthesis of Bioactive Molecules IV, University College Cork , 01-JUL-08 - 01-JUL-08. [Details]
(2007)Synthesis of Bioactive Molecules III,
Humphrey A. Moynihan ; (2007) . [Conference Organising Committee Member], Synthesis of Bioactive Molecules III, University College Cork , 20-APR-07 - 20-APR-07. [Details]
(2005)Synthesis of Bioactive Molecules II,
Humphrey A. Moynihan ; (2005) . [Conference Organising Committee Member], Synthesis of Bioactive Molecules II, University College Cork , 17-FEB-05 - 17-FEB-05. [Details]
(2004)Half-Day Seminar of Organic Chemistry, Royal Society of Chemistry/Analytical and Biological Chemistry Research, Facility, UCC,
Humphrey A. Moynihan ; (2004) . [Conference Organising Committee Member], Half-Day Seminar of Organic Chemistry, Royal Society of Chemistry/Analytical and Biological Chemistry Research, Facility, UCC, University College Cork , 22-APR-04 - 22-APR-04. [Details]
(2003)Analysis of Materials and Bio-materials, Royal Society of Chemistry/UCC Department of Chemistry Half-day Semina,
Humphrey A. Moynihan ; (2003) . [Conference Organising Committee Member], Analysis of Materials and Bio-materials, Royal Society of Chemistry/UCC Department of Chemistry Half-day Semina, University College Cork , 10-SEP-03 - 10-SEP-03. [Details]
(2007)European Federation of Chemical Engineers Working Party on Crystallization, Technical Meeting,
Guiry, K. P.; Coles, S. J.; Lawrence, S. E.; Moynihan, H. A; (2007) Aspects of D-Lactose Crystallization. [Oral Presentation], European Federation of Chemical Engineers Working Party on Crystallization, Technical Meeting, University College Dublin , 23-MAR-07 - 23-MAR-07. [Details]
(1995)Abstracts of European Chemical Society Symposium, Louvain La Neuve, Belgium (August),
Collins, C.; Cronin, M.; O'Flynn, K.; Moynihan, H.; McCarthy, D. G.; (1995) *. [N/A], Abstracts of European Chemical Society Symposium, Louvain La Neuve, Belgium (August), New Routes to Substituted Furanones [B382] , 01-JAN-95 - 30-DEC-99. [Details]

Patents

 Patent NumberTitleGranted
PCT/EP2008/0621Process for the preparation of the alpha crystal polymorph of metal phthalocyanines, 12-SEP-08

Honours and Awards

 YearTitleAwarding Body
2009Enterprise Ireland Award in recognition of the licensing Enterprise Ireland
2010UCC 1st Annual Research Commercialisation Award UCC

Employment

 EmployerPositionFrom / To
Department of Chemistry,University College Cork Lecturer in Organic Chemistry01-JAN-02 /
Liverpool John Moores University Lecturer in Organic Chemistry01-SEP-94 / 01-DEC-01
University of Bristol Postdoctoral Research Assistant01-OCT-92 / 01-AUG-94
University of Exeter Postdoctoral Research Fellow01-OCT-90 / 01-SEP-92

Education

 YearInstitutionQualificationSubject
1986University College Cork BSc HonsChemistry
1992University College Cork Ph.D.Organic Chemistry

Journal Activities

 JournalRoleTo / From
Carbohydrate Research Referee-
Crystal Engineering Communications Referee-
Journal Of Pharmacy And Pharmacology Referee-
Organic And Medicinal Chemistry Letters Referee-
Crystal Growth And Design Referee-

Teaching Activities

Teaching Interests

CM3110 Pharmaceutical Solids and Technology: A research inspired module on the pharmaceutical solid state delivered to 3rd year Chemistry of Pharmaceutical Compounds students. 

PF1010 Physicochemical Basis of Pharmaceuticals: An innovative module combining pharmaceutical chemistry and pharmaceutics to present the scientific underpinnings of medicines as materials to Pharmacy students.

CM2002/CM3030 Fundamentals of Organic Chemistry: Teaches core stereochemistry to 2nd year Science students (Chemistry, CPC, Chem Forensics, Biological Sciences and 3rd yr Process Engineers)

CM1006 Introductory Chemistry for Food and Nutritional Scientists: Presents the fundamentals of organic chemistry, molecular structure, functional groups,naming and reactions, to 1st year Food and Nutritional Science students. 

CM3102/PF2101 Introduction to Pharmaceutical Chemistry/Pharmaceutical Chemistry 2: Covers the fundamental principles for medicinal chemistry for Chemistry/CPC/CFS/Pharmacy students; including receptors, agonists, antagonists , physicochemical properties, adrenergic ligands and histamine receptor ligands.

CM3022 Synthesis Structure and Reactivity of Organic Compounds: advanced stereochemistry and core oxygen and nitrogen functional group chemistry for 3rd year Chemistry/CPC/CFS students.

Programme Coordinator BSc Chemistry of Pharmaceutical Compounds (CPC): Degree offers all core modules in Chemistry, Biochemistry, Physiology and Pharmacology; with special focus on Organic and Pharmaceutical Chemistry; 5 month industry work placement. Collaboration between the Departments of Chemistry, Biochemistry, Physiology, Pharmacology and the Careers Service. Excellent pharmaceutical industry engagement and strong recruitment. 

Recent Postgraduates

 Graduation YearStudent NameInstitutionDegree TypeThesis Title
2015Danielle Horgan UCCPHDOptimised crystal morphologies for active pharmaceutical ingredients and related studies
2010Andrea L. Ryan UCCPHDPolymorph-selective Crystal Nucleation Control Using Dendritic 'Tailor-made' Additives and Reactive Crystallisations
2012John A. Hayes UCCPHDStudies on the Crystallisation of Organic Compounds (Carbohydrates)
2011Dawn M. Kelly UCCPHDProbing and Controlling Crystal Nucleation and Growth
2009Marie T. McAuliffe UCCPHDDesign and Synthesis of Tailor-made Additives for the Control of Crystal Polymorphism
2011Kevin P. Guiry UCCPHDStudies on the Crystallisation of Lactose and Related Compunds
2014Lorna Lennon UCCPHDCrystallisation and crystal forms of carbohydrate derivatives

Modules Taught

 Term (ID))TitleLinkSubject
2020Introduction to Pharmaceutical Chemistry CM3102Introduction to Pharmaceutical Chemistry

Research Information

Internal Collaborators

 NameInstituteCountry
Dr. Simon E. Lawrence UCCIRELAND
Dr. Abina Crean UCCIRELAND
Prof. A. R. Maguire UCCIRELAND

External Collaborators

 NameOrganisation / InstituteCountry
Prof. Damien W. M. Arrigan Curtin Univerisity, Perth, AustraliaIRELAND
Prof. C. J. Rhodes Liverpool John Moores UniversityUNITED KINGDOM
Prof. R. J. Hamilton Liverpool John Moores UniversityUNITED KINGDOM

Contact details

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School of Food and Nutritional Sciences

School of Food and Nutritional Sciences, Room 240 Food Science Building, University College, Cork

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