Research Profile

Joseph O'Shea

Biography

Dr. Joey O'Shea is a Lecturer in Pharmaceutics in the School of Pharmacy, University College Cork. 
He completed his Bachelor of Pharmacy degree in UCC in 2012 and Master of Pharmacy degree in the Royal College of Surgeons in Ireland in 2013. Dr O'Shea completed his Ph.D. in the School of Pharmacy in UCC in 2018. The focus of his doctoral work was on the biopharmaceutical aspects of solid oral dose formulation performance and the predictive capacity of various in vitro, in vivo and in silico methods of characterisation for oral bio-enabling formulations. Following completion of his PhD, Dr O'Shea held numerous positions in the pharmaceutical industry in Ireland, including in formulation development, clinical and regulatory affairs and in process development and technical support. Dr O'Shea returned to academia in November 2019, taking up a role as Lecturer in Pharmaceutics in the School of Pharmacy, UCC. He currently teaches on the M.Pharm. undergraduate programme and on the MSc in Pharmaceutical Technology and Quality Systems, an on line masters course designed to train graduates working in the pharmaceutical industry to become a Qualified Person (QP). 

Publications

Book Chapters

 YearPublication
(2022)'Lipid‐based Formulations'
Joseph P O'Shea, Caitriona M O'Driscoll, Brendan T Griffin (2022) 'Lipid‐based Formulations' In: Edmund S. Kostewicz, Maria Vertzoni, Heather A. E. Benson, Michael S. Roberts (eds). Oral Drug Delivery for Modified Release Formulations. NJ, USA: John Wiley & Sons, Inc.   [DOI] [Details]

Peer Reviewed Journals

 YearPublication
(2022)'Best practices in current models mimicking drug permeability in the gastrointestinal tract - an UNGAP review'
O'Shea JP;Augustijns P;Brandl M;Brayden DJ;Brouwers J;Griffin BT;Holm R;Jacobsen AC;Lennernäs H;Vinarov Z;O'Driscoll CM; (2022) 'Best practices in current models mimicking drug permeability in the gastrointestinal tract - an UNGAP review'. European Journal of Pharmaceutical Sciences, 170 :106098-106133 [DOI] [Details]
(2021)'Exploring porcine gastric and intestinal fluids using microscopic and solubility estimates: Impact of placebo self-emulsifying drug delivery system administration to inform bio-predictive in vitro tools'
Bennett-Lenane, Harriet; Jørgensen, Jacob R.; Koehl, Niklas J.; Henze, Laura J.; O'Shea, Joseph P.; Müllertz, Anette; Griffin, Brendan T. (2021) 'Exploring porcine gastric and intestinal fluids using microscopic and solubility estimates: Impact of placebo self-emulsifying drug delivery system administration to inform bio-predictive in vitro tools'. European Journal of Pharmaceutical Sciences, 161 [DOI] [Full Text] [Details]
(2021)'Artificial neural networks to predict the apparent degree of supersaturation in supersaturated lipid-based formulations: A pilot study'
Bennett-Lenane, Harriet; O'Shea, Joseph P.; Murray, Jack D.; Ilie, Alexandra-Roxana; Holm, René; Kuentz, Martin; Griffin, Brendan T. (2021) 'Artificial neural networks to predict the apparent degree of supersaturation in supersaturated lipid-based formulations: A pilot study'. Pharmaceutics, 13 (9):1-14 [DOI] [Full Text] [Details]
(2021)'Machine learning methods for prediction of food effects on bioavailability: A comparison of support vector machines and artificial neural networks'
Bennett-Lenane, Harriet; Griffin, Brendan T.; O'Shea, Joseph P. (2021) 'Machine learning methods for prediction of food effects on bioavailability: A comparison of support vector machines and artificial neural networks'. European Journal of Pharmaceutical Sciences, [DOI] [Full Text] [Details]
(2021)'Combining species specific in vitro & in silico models to predict in vivo food effect in a preclinical stage – case study of Venetoclax'
Henze, Laura J.; Koehl, Niklas J.; O'Shea, Joseph P.; Holm, René; Vertzoni, Maria; Griffin, Brendan T. (2021) 'Combining species specific in vitro & in silico models to predict in vivo food effect in a preclinical stage – case study of Venetoclax'. European Journal of Pharmaceutical Sciences, 162 [DOI] [Full Text] [Details]
(2020)'A Retrospective Biopharmaceutical Analysis of >800 Approved Oral Drug Products: Are Drug Properties of Solid Dispersions and Lipid-Based Formulations Distinctive?'
Bennett-Lenane H.;O'Shea J.P.;O'Driscoll C.M.;Griffin B.T. (2020) 'A Retrospective Biopharmaceutical Analysis of >800 Approved Oral Drug Products: Are Drug Properties of Solid Dispersions and Lipid-Based Formulations Distinctive?'. Journal of Pharmaceutical Sciences, [DOI] [Details]
(2020)'Pre-clinical evaluation of a modified cyclodextrin-based nanoparticle for intestinal delivery of Liraglutide'
Presas E;Tovar S;Cuñarro J;O'Shea JP;O'Driscoll CM; (2020) 'Pre-clinical evaluation of a modified cyclodextrin-based nanoparticle for intestinal delivery of Liraglutide'. Journal of Pharmaceutical Sciences, [DOI] [Details]
(2020)'Applying computational predictions of biorelevant solubility ratio upon self-emulsifying lipid-based formulations dispersion to predict dose number'
Bennett-Lenane, Harriet; Koehl, Niklas J.; O'Dwyer, Patrick J.; Box, Karl J.; O'Shea, Joseph P.; Griffin, Brendan T. (2020) 'Applying computational predictions of biorelevant solubility ratio upon self-emulsifying lipid-based formulations dispersion to predict dose number'. Journal of Pharmaceutical Sciences, [DOI] [Full Text] [Details]
(2019)'Food for thought: formulating away the food effect - a PEARRL review'
O'Shea JP;Holm R;O'Driscoll CM;Griffin BT; (2019) 'Food for thought: formulating away the food effect - a PEARRL review'. Journal of Pharmacy and Pharmacology, 71 (4)   [DOI] [Full Text] [Details]
(2019)'Toward the establishment of a standardized pre-clinical porcine model to predict food effects - case studies on Fenofibrate and Paracetamol'
Henze, Laura J.; Koehl, Niklas J.; O'Shea, Joseph P.; Holm, René; Vertzoni, Maria; Griffin, Brendan T. (2019) 'Toward the establishment of a standardized pre-clinical porcine model to predict food effects - case studies on Fenofibrate and Paracetamol'. International Journal Of Pharmaceutics: X,   [DOI] [Full Text] [Details]
(2019)'The pig as a preclinical model for predicting oral bioavailability and in vivo performance of pharmaceutical oral dosage forms: a PEARRL review'
Henze, Laura J.; Koehl, Niklas J.; O'Shea, Joseph P.; Kostewicz, Edmund S.; Holm, René; Griffin, Brendan T. (2019) 'The pig as a preclinical model for predicting oral bioavailability and in vivo performance of pharmaceutical oral dosage forms: a PEARRL review'. Journal of Pharmacy and Pharmacology, [Details]
(2017)'Mesoporous silica based dosage forms improve bioavailability of poorly soluble drugs in pigs: case example fenofibrate'
Joseph P. O’Shea, Kalpa Nagarsekar, Alena Wieber, Vanessa Witt3, Elisabeth Herbert, Caitriona M. O’Driscoll, Christoph Saal, Dieter Lubda, Brendan T. Griffin, Jennifer B. Dressman (2017) 'Mesoporous silica based dosage forms improve bioavailability of poorly soluble drugs in pigs: case example fenofibrate'. Journal of Pharmacy and Pharmacology,   [DOI] [Details]
(2017)'In vitro dissolutionmodels for the prediction of in vivo performance of an oral mesoporous silica formulation'
McCarthy, CA;Faisal, W;O'Shea, JP;Murphy, C;Ahern, RJ;Ryan, KB;Griffin, BT;Crean, AM (2017) 'In vitro dissolutionmodels for the prediction of in vivo performance of an oral mesoporous silica formulation'. Journal Of Controlled Release, 250 :86-95 [DOI] [Details]
(2016)'Folate-targeted amphiphilic cyclodextrin.siRNA nanoparticles for prostate cancer therapy exhibit PSMA mediated uptake, therapeutic gene silencing in vitro and prolonged circulation in vivo'
Evans, J. C.,Malhotra, M.,Guo, J.,O'Shea, J. P.,Hanrahan, K.,O'Neill, A.,Landry, W. D.,Griffin, B. T.,Darcy, R.,Watson, R. W.,O'Driscoll, C. M. (2016) 'Folate-targeted amphiphilic cyclodextrin.siRNA nanoparticles for prostate cancer therapy exhibit PSMA mediated uptake, therapeutic gene silencing in vitro and prolonged circulation in vivo'. Nanomedicine, 12 (8):2341-2351   [DOI] [Details]
(2015)'Lipidic dispersion to reduce food dependent oral bioavailability of fenofibrate: In vitro, in vivo and in silico assessments'
O'Shea, JP;Faisal, W;Ruane-O'Hora, T;Devine, KJ;Kostewicz, ES;O'Driscoll, CM;Griffin, BT (2015) 'Lipidic dispersion to reduce food dependent oral bioavailability of fenofibrate: In vitro, in vivo and in silico assessments'. European Journal Of Pharmaceutics And Biopharmaceutics, 96 :207-216 [DOI] [Details]

Professional Activities

Professional Associations

 AssociationFunctionFrom / To
Pharmaceutical Society of Ireland Member01-DEC-13 /
Pharmacists in Industry, Education and Regulatory Committee Member01-DEC-20 /

Committees

 CommitteeFunctionFrom / To
European Industrial Pharmacists Group (EIPG) Irish Delegate/
Pharmacists in Industry, Education and Regulatory (PIER) Committee Member/

Employment

 EmployerPositionFrom / To
EirGen Pharma Ltd Formulation Scientist/ Clinical Affairs Officer01-NOV-17 / 01-MAR-19
AbbVie Inc Process Scientist03-MAR-19 / 01-NOV-19
University College Cork Lecturer in Pharmaceutics01-NOV-19 /

Education

 YearInstitutionQualificationSubject
2012University College Cork Bachelor of PharmacyPharmacy
2018University College Cork Doctor of PhilosphyPharmaceutics
2013Royal College of Surgeons in Ireland Master of PharmacyPharmacy
2021University College Cork Postgraduate Certificate in Teaching and Learning in Higher EducationTeaching & Learning

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University College Cork

Coláiste na hOllscoile Corcaigh

College Road, Cork T12 K8AF

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