Research Profile

Patrick O'Dwyer

Biography

Dr. Patrick O'Dwyer is currently a lecturer in Pharmaceutics at the School of Pharmacy in University College Cork. He received his Bachelor of Pharmacy (BPharm) degree from University College Cork in 2015 and completed his Master of Pharmacy (MPharm) degree from the Royal College of Surgeons in Ireland in 2016.

Dr. O'Dwyer completed his PhD in 2020 from the National and Kapodistrian University of Athens under the supervision of Prof Christos Reppas, as part of the PEARRL (Pharmaceutical Education And Research with Regulatory Links) project, a European Training Network funded under the EU Horizon 2020 research and innovation programme (Marie Sklodowska-Curie actions). His PhD research was conducted in Pion Inc. (UK) Ltd. and the National and Kapodistrian University of Athens, with a secondment in the European Medicines Agency also completed as part of the project.

Research Interests

  • Biorelevant dissolution testing
  • Physiologically based pharmacokinetic (PBPK) modeling
  • Computational Pharmaceutics
  • Regulatory Science
  • Novel approaches to enhance oral drug delivery


Publications

Peer Reviewed Journals

 YearPublication
(2023)'Leveraging the use of in vitro and computational methods to support the development of enabling oral drug products: An InPharma commentary'
Reppas C;Kuentz M;Bauer-Brandl A;Carlert S;Dallmann A;Dietrich S;Dressman J;Ejskjaer L;Frechen S;Guidetti M;Holm R;Holzem FL;Karlsson ¿;Kostewicz E;Panbachi S;Paulus F;Senniksen MB;Stillhart C;Turner DB;Vertzoni M;Vrenken P;Zöller L;Griffin BT;O'Dwyer PJ; (2023) 'Leveraging the use of in vitro and computational methods to support the development of enabling oral drug products: An InPharma commentary'. European Journal of Pharmaceutical Sciences, 188 [DOI] [Details]
(2023)'Advancing Algorithmic Drug Product Development: Recommendations for Machine Learning Approaches in Drug Formulation'
Murray JD;Lange JJ;Bennett-Lenane H;Holm R;Kuentz M;O'Dwyer PJ;Griffin BT; (2023) 'Advancing Algorithmic Drug Product Development: Recommendations for Machine Learning Approaches in Drug Formulation'. European Journal of Pharmaceutical Sciences, [DOI] [Details]
(2021)'Oral biopharmaceutics tools: recent progress from partnership through the Pharmaceutical Education and Research with Regulatory Links collaboration'
O'Dwyer PJ;Box KJ;Dressman J;Griffin BT;Henze LJ;Litou C;Pentafragka C;Statelova M;Vertzoni M;Reppas C; (2021) 'Oral biopharmaceutics tools: recent progress from partnership through the Pharmaceutical Education and Research with Regulatory Links collaboration'. Journal of Pharmacy and Pharmacology, 73 (4) [DOI] [Details]
(2021)'On the usefulness of four in vitro methodologies in screening for product related differences in tacrolimus exposure after oral administration of amorphous solid dispersions with modified release characteristics in the fasted state'
Tsakiridou, Georgia; O'Dwyer, Patrick J.; Margaritis, Antonios; Box, Karl J.; Vertzoni, Maria; Kalantzi, Lida; Reppas, Christos; (2021) 'On the usefulness of four in vitro methodologies in screening for product related differences in tacrolimus exposure after oral administration of amorphous solid dispersions with modified release characteristics in the fasted state'. Journal of Drug Delivery Science and Technology, [DOI] [Full Text] [Details]
(2021)'On the usefulness of four in vitro methods in assessing the intraluminal performance of poorly soluble, ionisable compounds in the fasted state'
O'Dwyer PJ;Box KJ;Imanidis G;Vertzoni M;Reppas C; (2021) 'On the usefulness of four in vitro methods in assessing the intraluminal performance of poorly soluble, ionisable compounds in the fasted state'. European Journal of Pharmaceutical Sciences, 168 [DOI] [Details]
(2020)'On the Usefulness of Two Small-Scale In Vitro Setups in the Evaluation of Luminal Precipitation of Lipophilic Weak Bases in Early Formulation Development'
O'Dwyer PJ;Imanidis G;Box KJ;Reppas C; (2020) 'On the Usefulness of Two Small-Scale In Vitro Setups in the Evaluation of Luminal Precipitation of Lipophilic Weak Bases in Early Formulation Development'. Pharmaceutics, 12 (3) [DOI] [Details]
(2020)'Applying computational predictions of biorelevant solubility ratio upon self-emulsifying lipid-based formulations dispersion to predict dose number'
Bennett-Lenane, Harriet; Koehl, Niklas J.; O'Dwyer, Patrick J.; Box, Karl J.; O'Shea, Joseph P.; Griffin, Brendan T. (2020) 'Applying computational predictions of biorelevant solubility ratio upon self-emulsifying lipid-based formulations dispersion to predict dose number'. Journal of Pharmaceutical Sciences, [DOI] [Full Text] [Details]
(2020)'Novel Biphasic Lipolysis Method To Predict in Vivo Performance of Lipid-Based Formulations'
O'Dwyer PJ;Box KJ;Koehl NJ;Bennett-Lenane H;Reppas C;Holm R;Kuentz M;Griffin BT; (2020) 'Novel Biphasic Lipolysis Method To Predict in Vivo Performance of Lipid-Based Formulations'. Molecular Pharmaceutics, [DOI] [Full Text] [Details]
(2019)'In vitro methods to assess drug precipitation in the fasted small intestine - a PEARRL review'
O'Dwyer PJ;Litou C;Box KJ;Dressman JB;Kostewicz ES;Kuentz M;Reppas C; (2019) 'In vitro methods to assess drug precipitation in the fasted small intestine - a PEARRL review'. Journal of Pharmacy and Pharmacology, 71 (4) [DOI] [Details]
(2019)'Biphasic drug release testing coupled with diffusing wave spectroscopy for mechanistic understanding of solid dispersion performance'
Jankovic S.;O'Dwyer P.;Box K.;Imanidis G.;Reppas C.;Kuentz M. (2019) 'Biphasic drug release testing coupled with diffusing wave spectroscopy for mechanistic understanding of solid dispersion performance'. European Journal of Pharmaceutical Sciences, 137 [DOI] [Details]

Conference Publications

 YearPublication
(2022)AAPS Annual Meeting
Ejskjær L.;O'Dwyer P.J.;Holm R.;Kuentz M.;Griffin B.T. (2022) Developing an in vitro lipolysis model for real-time analysis of drug concentrations during digestion of lipid-based formulations AAPS Annual Meeting [Details]
(2020)AAPS Annual Meeting
Bennett-Lenane, H.; Koehl, N. J.; O’Dwyer, P. J.; Box, K. J.; O’Shea, J. P.; Griffin, B. T. (2020) Applying Computational Prediction of Biorelevant Solubility in Dispersions of Self-Emulsifying Lipid-Based Formulations to Predict Dose Number AAPS Annual Meeting [Details]
(2019)AAPS Annual Meeting
O’Dwyer P. J., Koehl N. J., Box K. J., Griffin B. T., Holm R., Kuentz M., Reppas C. (2019) Novel Biphasic Lipolysis Testing of Nilotinib Lipid-Based Suspensions to Predict In Vivo Performance AAPS Annual Meeting [Details]
(2019)AAPS Annual Meeting
O’Dwyer P. J., Box K. J., Reppas C. (2019) Usefulness of Small-Scale Biphasic Dissolution Experiments in Estimating Precipitation Rates for Input in PBPK Modelling AAPS Annual Meeting [Details]
(2018)AAPS Annual Meeting
O’Dwyer P. J., Box K. J., Reppas C. (2018) Small Scale Biphasic Dissolution Testing of Itraconazole (ITZ) Formulations with a pH Shift AAPS Annual Meeting [Details]
(2017)AAPS Annual Meeting
O’Dwyer P.J., Box K.J., Watson H., Taylor R. (2017) In Vitro Modelling of Propranolol Immediate Release (IR) and Extended Release (ER) Formulations using a Three Chamber Dissolution Apparatus AAPS Annual Meeting [Details]
(2017)IAPC-6 Meeting
O’Dwyer P. J., Comer J., Taylor R., Box K. J. (2017) Small Scale Biphasic Dissolution testing of Dipyridamole Suspension IAPC-6 Meeting [Details]
(2017)AAPS Annual Meeting
Watson H., Box K.J., O'Dwyer P.J., Gehris A. (2017) Understanding Drug Release Mechanisms of Metformin using complementary in vitro Dissolution Tools AAPS Annual Meeting [Details]

Professional Activities

Honours and Awards

 YearTitleAwarding Body
2015School of Pharmacy Gold Medal UCC School of Pharmacy
2015Dr. H.H. Stewart Medical Scholarship and Prize in Pharmacy National University of Ireland
2015Abbvie Prize for excellence in Pharmaceutics UCC School of Pharmacy
2013Quercus scholarship in Pharmacy University College Cork
2011Quercus scholarship in Pharmacy University College Cork

Professional Associations

 AssociationFunctionFrom / To
Pharmaceutical Society of Ireland Member30-NOV-16 /
PIER (Pharmacists in Industry Education and Regulatory) Member29-JUN-19 /

Education

 YearInstitutionQualificationSubject
2021University College Cork Postgraduate CertificateTeaching and Learning in Higher Education
2020National and Kapodistrian University of Athens PhDPharmaceutics
2016Royal College of Surgeons in Ireland MPharmPharmacy
2015University College Cork BPharmPharmacy

Teaching Activities

Teaching Interests

PF1012 - Introduction to Pharmaceutics: Formulation Science
PF3014 - Regulatory Science
PF3015 - Pharmacokinetics: From Basic Principles to Clinical Applications
PF6028 - Process Control and Validation for Pharmaceutical Processes with Regulatory Insights
PF6030 - Industrial-based project and skills development for an industry-based setting
PF6301 - Biopharmaceuticals: Formulation Design, Secondary Processing and Regulatory compliance

Course Director for PG Dip in Pharmaceutical Regulatory Sciences








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University College Cork

Coláiste na hOllscoile Corcaigh

College Road, Cork T12 K8AF

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