TY  - JOUR
  - Strelau, J., Bottner, M., Lingor, P., Suter-Crazzolara, C., Galter, D., Jaszai, J., Sullivan, A., Schober, A., Krieglstein, K., Unsicker, K.
  - 2000
  - January
  - Journal of neural transmission. Supplementum
  - GDF-15/MIC-1 a novel member of the TGF-beta superfamily.
  - Validated
  - ()
  - 60
  - 273
  - 276
  - We have cloned, expressed, and raised antibodies against a novel member of the TGF-beta superfamily, growth/differentiation factor-15 (GDF-15). The predicted protein is identical to macrophage inhibitory cytokine-1 (MIC-1), which was discovered simultaneously. GDF-15 is a more distant member of the TGF-beta superfamily and does not belong to one of the known TGF-beta subfamilies. In the CNS, GDF-15/MIC-1 mRNA is abundantly expressed by the choroid plexus. In addition we have preliminary evidence that GDF-15/MIC-1 is a potent trophic factor for selected classes of neurons in vitro and in vivo. Thus, GDF-15 is a novel neurotrophic factor with prospects for the treatment of disorders of the CNS.
DA  - 2000/01
ER  - 

@article{V286420882,
   = {Strelau,  J. and  Bottner,  M. and  Lingor,  P. and  Suter-Crazzolara,  C. and  Galter,  D. and  Jaszai,  J. and  Sullivan,  A. and  Schober,  A. and  Krieglstein,  K. and  Unsicker,  K. },
   = {2000},
   = {January},
   = {Journal of neural transmission. Supplementum},
   = {GDF-15/MIC-1 a novel member of the TGF-beta superfamily.},
   = {Validated},
   = {()},
   = {60},
  pages = {273--276},
   = {{We have cloned, expressed, and raised antibodies against a novel member of the TGF-beta superfamily, growth/differentiation factor-15 (GDF-15). The predicted protein is identical to macrophage inhibitory cytokine-1 (MIC-1), which was discovered simultaneously. GDF-15 is a more distant member of the TGF-beta superfamily and does not belong to one of the known TGF-beta subfamilies. In the CNS, GDF-15/MIC-1 mRNA is abundantly expressed by the choroid plexus. In addition we have preliminary evidence that GDF-15/MIC-1 is a potent trophic factor for selected classes of neurons in vitro and in vivo. Thus, GDF-15 is a novel neurotrophic factor with prospects for the treatment of disorders of the CNS.}},
  source = {IRIS}
}