TY  - JOUR
  - Sullivan, A.M. Reynolds, D.S., Thomas, K.L., Morton, A.J.
  - 1996
  - December
  - Neuroreport
  - Cortical induction of c-fos by intrastriatal endothelin-1 is mediated via NMDA receptors.
  - Validated
  - ()
  - 8
  - 1
  - 211
  - 216
  - Endothelin (ET) is a potent vasoconstrictor which has also been proposed to act as a neuromodulator. We have investigated the action of ET-1 on neurones in vivo, using c-fos as a marker of neuronal activation. Intrastriatal injection of ET-1 caused seizures and barrel rolling which were prevented by pretreatment with the N-methyl-D-aspartate (NMDA) receptor antagonist MK-801 and attenuated by the nitric-oxide synthase inhibitor N omega-nitro-L-arginine (L-NNA). In association with these behaviours, a dramatic increase in c-fos mRNA expression was seen in the cerebral cortex. This increase was blocked by both MK-801 and L-NNA. We suggest that ET-1 modulates the activity of cortical afferents to the striatum, and causes seizures via an NMDA receptor-dependent mechanism.
DA  - 1996/12
ER  - 

@article{V286420932,
   = {Sullivan,  A.M. Reynolds and  D.S.,  Thomas and  K.L.,  Morton and  A.J. },
   = {1996},
   = {December},
   = {Neuroreport},
   = {Cortical induction of c-fos by intrastriatal endothelin-1 is mediated via NMDA receptors.},
   = {Validated},
   = {()},
   = {8},
   = {1},
  pages = {211--216},
   = {{Endothelin (ET) is a potent vasoconstrictor which has also been proposed to act as a neuromodulator. We have investigated the action of ET-1 on neurones in vivo, using c-fos as a marker of neuronal activation. Intrastriatal injection of ET-1 caused seizures and barrel rolling which were prevented by pretreatment with the N-methyl-D-aspartate (NMDA) receptor antagonist MK-801 and attenuated by the nitric-oxide synthase inhibitor N omega-nitro-L-arginine (L-NNA). In association with these behaviours, a dramatic increase in c-fos mRNA expression was seen in the cerebral cortex. This increase was blocked by both MK-801 and L-NNA. We suggest that ET-1 modulates the activity of cortical afferents to the striatum, and causes seizures via an NMDA receptor-dependent mechanism.}},
  source = {IRIS}
}