IRIS publication 38718212
Neonatal maternal separation in the rat impacts on the stress responsivity of central corticotropin-releasing factor receptors in adulthood.
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TY - JOUR - O'Malley, D; Dinan, TG; Cryan, JF - 2010 - May - Psychopharmacology - Neonatal maternal separation in the rat impacts on the stress responsivity of central corticotropin-releasing factor receptors in adulthood. - Validated - () - Adverse events during early developmental stages can induce persistent changes in central stress circuits, leading to increased stress sensitivity in adulthood, as is apparent in the maternally separated (MS) rat model. It is widely accepted that the stress peptide corticotropin-releasing factor (CRF) by binding to CRF1 and 2 receptors (CRFR1 and CRFR2) is key to these phenotypic changes. - 10.1007/s00213-010-1885-9 DA - 2010/05 ER -
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@article{V38718212, = {O'Malley, D and Dinan, TG and Cryan, JF}, = {2010}, = {May}, = {Psychopharmacology}, = {Neonatal maternal separation in the rat impacts on the stress responsivity of central corticotropin-releasing factor receptors in adulthood.}, = {Validated}, = {()}, = {{Adverse events during early developmental stages can induce persistent changes in central stress circuits, leading to increased stress sensitivity in adulthood, as is apparent in the maternally separated (MS) rat model. It is widely accepted that the stress peptide corticotropin-releasing factor (CRF) by binding to CRF1 and 2 receptors (CRFR1 and CRFR2) is key to these phenotypic changes.}}, = {10.1007/s00213-010-1885-9}, source = {IRIS} }
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AUTHORS | O'Malley, D; Dinan, TG; Cryan, JF | ||
YEAR | 2010 | ||
MONTH | May | ||
JOURNAL_CODE | Psychopharmacology | ||
TITLE | Neonatal maternal separation in the rat impacts on the stress responsivity of central corticotropin-releasing factor receptors in adulthood. | ||
STATUS | Validated | ||
TIMES_CITED | () | ||
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ABSTRACT | Adverse events during early developmental stages can induce persistent changes in central stress circuits, leading to increased stress sensitivity in adulthood, as is apparent in the maternally separated (MS) rat model. It is widely accepted that the stress peptide corticotropin-releasing factor (CRF) by binding to CRF1 and 2 receptors (CRFR1 and CRFR2) is key to these phenotypic changes. | ||
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DOI_LINK | 10.1007/s00213-010-1885-9 | ||
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