Neonatal maternal separation in the rat impacts on the stress responsivity of central corticotropin-releasing factor receptors in adulthood.

Typeset version

 

TY  - JOUR
  - O'Malley, D; Dinan, TG; Cryan, JF
  - 2010
  - May
  - Psychopharmacology
  - Neonatal maternal separation in the rat impacts on the stress responsivity of central corticotropin-releasing factor receptors in adulthood.
  - Validated
  - ()
  - Adverse events during early developmental stages can induce persistent changes in central stress circuits, leading to increased stress sensitivity in adulthood, as is apparent in the maternally separated (MS) rat model. It is widely accepted that the stress peptide corticotropin-releasing factor (CRF) by binding to CRF1 and 2 receptors (CRFR1 and CRFR2) is key to these phenotypic changes.
  - 10.1007/s00213-010-1885-9
DA  - 2010/05
ER  - 
@article{V38718212,
   = {O'Malley, D and  Dinan, TG and  Cryan, JF},
   = {2010},
   = {May},
   = {Psychopharmacology},
   = {Neonatal maternal separation in the rat impacts on the stress responsivity of central corticotropin-releasing factor receptors in adulthood.},
   = {Validated},
   = {()},
   = {{Adverse events during early developmental stages can induce persistent changes in central stress circuits, leading to increased stress sensitivity in adulthood, as is apparent in the maternally separated (MS) rat model. It is widely accepted that the stress peptide corticotropin-releasing factor (CRF) by binding to CRF1 and 2 receptors (CRFR1 and CRFR2) is key to these phenotypic changes.}},
   = {10.1007/s00213-010-1885-9},
  source = {IRIS}
}
AUTHORSO'Malley, D; Dinan, TG; Cryan, JF
YEAR2010
MONTHMay
JOURNAL_CODEPsychopharmacology
TITLENeonatal maternal separation in the rat impacts on the stress responsivity of central corticotropin-releasing factor receptors in adulthood.
STATUSValidated
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ABSTRACTAdverse events during early developmental stages can induce persistent changes in central stress circuits, leading to increased stress sensitivity in adulthood, as is apparent in the maternally separated (MS) rat model. It is widely accepted that the stress peptide corticotropin-releasing factor (CRF) by binding to CRF1 and 2 receptors (CRFR1 and CRFR2) is key to these phenotypic changes.
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URL
DOI_LINK10.1007/s00213-010-1885-9
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