IRIS publication 43336819
Antidepressant therapy and C-reactive protein levels
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TY - JOUR - O'Brien, SM,Scott, LV,Dinan, TG - 2006 - May - Rna-A Publication of The Rna Society - Antidepressant therapy and C-reactive protein levels - Validated - () - CORONARY-ARTERY-DISEASE ACUTE-PHASE PROTEINS MAJOR DEPRESSION CARDIOVASCULAR-DISEASE INFLAMMATION MARKERS PREDICTION ACTIVATION - 188 - 449 - 452 - Background Major depression is associated with activation of the inflammatory response.Aims To examine C-reactive protein levels in depression and to determine the impact of selective serotonin reuptake inhibitor (SSRI) therapy.Method A two-part study In study 1, which used a between -subjects design, C-reactive protein was measured in 32 patients (20 currently depressed, 12 euthymic) with a history of DSM - IV major depression, all of whom were treated with an SSRI, and in a healthy comparison group (n=20). Study 2 employed a within-subject design: C-reactive protein was measured in 20 patients with major depression both before and after SSRI treatment.Results In study 1, C- reactive protein levels did not differ between the group with depressive disorder (either currently depressed or euthymic) treated with SSRIs and the healthy group. In study 2 the protein levels dropped significantly following treatment with antidepressant medication.Conclusions Following SSRI treatment for major depression there is a significant drop in C-reactive protein concentrations whether or not the depression resolves. These findings indicate that antidepressants induce an anti -inflammatory response independent of antidepressant action.Declaration of interest T.G.D. has lectured at meetings sponsored by or acted as an advisor to all companies who market a branded SSRI. DA - 2006/05 ER -
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@article{V43336819, = {O'Brien, SM and Scott, LV and Dinan, TG }, = {2006}, = {May}, = {Rna-A Publication of The Rna Society}, = {Antidepressant therapy and C-reactive protein levels}, = {Validated}, = {()}, = {CORONARY-ARTERY-DISEASE ACUTE-PHASE PROTEINS MAJOR DEPRESSION CARDIOVASCULAR-DISEASE INFLAMMATION MARKERS PREDICTION ACTIVATION}, = {188}, pages = {449--452}, = {{Background Major depression is associated with activation of the inflammatory response.Aims To examine C-reactive protein levels in depression and to determine the impact of selective serotonin reuptake inhibitor (SSRI) therapy.Method A two-part study In study 1, which used a between -subjects design, C-reactive protein was measured in 32 patients (20 currently depressed, 12 euthymic) with a history of DSM - IV major depression, all of whom were treated with an SSRI, and in a healthy comparison group (n=20). Study 2 employed a within-subject design: C-reactive protein was measured in 20 patients with major depression both before and after SSRI treatment.Results In study 1, C- reactive protein levels did not differ between the group with depressive disorder (either currently depressed or euthymic) treated with SSRIs and the healthy group. In study 2 the protein levels dropped significantly following treatment with antidepressant medication.Conclusions Following SSRI treatment for major depression there is a significant drop in C-reactive protein concentrations whether or not the depression resolves. These findings indicate that antidepressants induce an anti -inflammatory response independent of antidepressant action.Declaration of interest T.G.D. has lectured at meetings sponsored by or acted as an advisor to all companies who market a branded SSRI.}}, source = {IRIS} }
Data as stored in IRIS
AUTHORS | O'Brien, SM,Scott, LV,Dinan, TG | ||
YEAR | 2006 | ||
MONTH | May | ||
JOURNAL_CODE | Rna-A Publication of The Rna Society | ||
TITLE | Antidepressant therapy and C-reactive protein levels | ||
STATUS | Validated | ||
TIMES_CITED | () | ||
SEARCH_KEYWORD | CORONARY-ARTERY-DISEASE ACUTE-PHASE PROTEINS MAJOR DEPRESSION CARDIOVASCULAR-DISEASE INFLAMMATION MARKERS PREDICTION ACTIVATION | ||
VOLUME | 188 | ||
ISSUE | |||
START_PAGE | 449 | ||
END_PAGE | 452 | ||
ABSTRACT | Background Major depression is associated with activation of the inflammatory response.Aims To examine C-reactive protein levels in depression and to determine the impact of selective serotonin reuptake inhibitor (SSRI) therapy.Method A two-part study In study 1, which used a between -subjects design, C-reactive protein was measured in 32 patients (20 currently depressed, 12 euthymic) with a history of DSM - IV major depression, all of whom were treated with an SSRI, and in a healthy comparison group (n=20). Study 2 employed a within-subject design: C-reactive protein was measured in 20 patients with major depression both before and after SSRI treatment.Results In study 1, C- reactive protein levels did not differ between the group with depressive disorder (either currently depressed or euthymic) treated with SSRIs and the healthy group. In study 2 the protein levels dropped significantly following treatment with antidepressant medication.Conclusions Following SSRI treatment for major depression there is a significant drop in C-reactive protein concentrations whether or not the depression resolves. These findings indicate that antidepressants induce an anti -inflammatory response independent of antidepressant action.Declaration of interest T.G.D. has lectured at meetings sponsored by or acted as an advisor to all companies who market a branded SSRI. | ||
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